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Precipitating factors

• Vitmain D

• Increase

calcium

• Hypothyroidis

Predisposing factors

• Age

• Sex

• Sedentary

lifestyle

Supersaturation of 

urine,

 

decrease

bladder motility

formation of 

small

turbid/cloudy

urine

movements of 

calculi to stones tothe ureters by the

increase pressure

 

distended

bladdercalculistones

Excretion of 

tiny stones

formation of 

large

crystallites

 

decrease

urinary output

Release of 

erythropeitin fr.

Adrenal gland

excretion of 

RBC to the

Stimulation of nociceptors

through mechanical force

exerted by increase pressure

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Stimulation of

bone marrow t

increase RBC

damage to the

surrounding tissue/

 

Transformation

of stimulus to

impulse up to the

 

vasodilati

Stimulates

hypothalamu

Lab. increase

RBC rate

Cell death on the

surrounding

tissue/bladder/kidney

vasoconstricti

on affected

Release

of 

chemical

impulse

reach

thalamus

 

Impulse to

limbic

s stem

pain

perceptionGrimace

monocyte

activate to

macropha

fibrinoge

n

activate

T-helper

Activate

Immune

Clot

affected

Increase

capillary

Edema

body

temp.

An

Bod

wea

Allow colonization

of bacterialRB

CUTIRelease

urease

Decrease

Acidity urine

bacterial

Ascending bacterial

Infection to the

Pyelonephrit

urosepsis

Sepsis

Systemic

infection

Organ

cardiac arrest,

respiratory failure

Ex. peritonitis,

meningitis

Affect organ

No sup

in the

Brain

dama

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DEA