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CURRICULAM VITAE
Venkatesham Rachakonda
Panchavati Colony
H. No: 5-55/25
Medipally
Ranga Reddy
Hyderabad
PIN 508 285 Ph No: +91 9908629129
E-mail:[email protected]
OBJECTIVE
To be professionally associated with an organization, which can provides career growth with an
objective to accept the challenges and achieving towards discovery of new therapeutic agents and
devolopment of new methodologies.
PROFESSIONAL QUALIFICATION
2009-2014, Ph.D. (Chemistry), Thesis submitted to Kakatiya University, Warangal, Telangana state,
India. Work done at CSIR-Indian Institute of Chemical Technology (I.I.C.T), Hyderabad
under the supervision of Dr. A. Manjula, Principal Scientist, CSIR-IICT.
� Ph.D. thesis entitled “Quinolinyl Heterocycles as Antimycobacterial Agents: Design
Diversity-Oriented Synthesis, Structure Activity Relationship and Active Analogues
Optimization".
2008, Qualified National Eligibility Test (NET) and selected for UGC-Junior Research Fellowship
(JRF) which is jointly conducted by CSIR-UGC (Council of Scientific and Industrial
Research-University Grants Commission), Govt. of India, New Delhi, India.
2005-2007, Master of Science (M.Sc) in Organic Chemistry (Medicinal Chemistry as elective) with first
Division from Kakatiya University, Warangal, Telangana state, India.
2002-2005, Bachelor of Science (B.Sc) (Chemistry, Mathematics and Physics) with first Division from
Osmania University, Hyderabad, Telangana state, India.
TRAININGS UNDERGONE
� Experienced in design, diversity oriented synthesis and hit identification of biologically active
heterocyclic moieties.
� Experienced in establishment of Structure Activity Relationship (SAR).
� Experienced in lead optimization and lead generation of active hits.
� Experienced in conducting Multi Component Reactions (MCRs) and Solvent Free reactions.
� I have basic knowledge in molecular modelling studies.
� Capable of doing collaborative and independent research work.
� Familiar with deadline management, work priority and professional reporting.
� Familiar with commonly used computer software. MS-OFFICE, (Word, Excel & Power Point).
� Familiar to commonly used chemistry related software such as Chem draw, ISIS Draw, mestrec23,
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ACS CA on CD, Beilstien Cross fire, Reaxys® and SciFinder.
STUDENTS TRAINED DURING MY DOCTORAL RESEARCH
During my course of Ph.D, I trained five postgraduate students parallel to my work
RESEARCH INTEREST
Discovery of novel therapautic.
Development of new synthetic methodologies (API).
LIST OF PUBLICATIONS
1) “Design, diversity-oriented synthesis and structure activity relationship studies of quinolinyl
heterocycles as antimycobacterial agents” Venkatesham Rachakonda, Manjula Alla, Sudha Sravanti
Kotipalli, Ramesh Ummanni. Eur. J. Med. Chem. 2013, 70, 536-547.
2). “(Bromodimethylsulfonium) bromide catalyzed solvent free Friedlander synthesis of substituted
quinolines” R. Venkatesham, A. Manjula, B. Vittal Rao. J. Heterocyclic. Chem, 2012, 49, 833-838.
3). “(Bromodimethylsulfonium) bromide catalyzed one pot three component synthesis of imidazo[1,2-
a]pyridines” R. Venkatesham, A. Manjula, B. Vittal Rao. J. Heterocyclic. Chem, 2011, 48, 942-947.
4) “Quinolinyl heterocycles as antimycobacterial agents: Towards structure optimization of the active
analogues 2-methyl-3-(1H-pyrazol-5-yl)quinoline and 3-(5-(2-methylquinolin-3-yl)-1,3,4-oxadiazol-2-
yl)-4H-chromen-4-one” Venkatesham Rachakonda, Manjula Alla, Sudha Sravanti Kotapalli,
Ramesh Ummanni. Communicated to Med. Chem. Commun.
5) “Synthesis and biological evaluation of 2-(2-methylquinolin-3-yl)-5-aryl/alkyl-1,3,4-oxadiazoles” R.
Venkatesham, A. Manjula. Communicated to Med. Chem. Res.
POSTER PRESENTATIONS & CONFERENCES ATTENDED
Poster Presentations
1) Organic Synthesis and Human Well Being: Emerging Opportunities and Challenges (OSHWD-
2010) held on August 1-4, 2010 at I.I.C.T, Hyderabad, India.
A mild and efficient solvent free synthesis of quinolines and dihydroquinoxaline amine
derivatives (Page No 159). R. Venkatesham, A. Manjula, B. Vittal Rao
2) National Conference on Green Chemistry-An Innovation to Sustainable Development held on
29th
and 30th
March 2010 at Department of chemistry, Kakatiya University, Warangal, India.
Presented work has been selected for “Second Best Poster Presentation”.
(Bromodimethyl sulfonium) bromide mediated one pot three component synthesis of
imidazo[1,2-a]pyridine (GC-17, Page No 17). R. Venkatesham, A. Manjula, B. Vittal Rao.
3) The Royal Society of Chemistry (London)-DS-National Poster Symposium on
Organic/Medicinal Chemistry for Ph.D Students. Conducted by Royal Society of Chemistry
(London), Deccan Section at I.I.C.T, Hyderabad, India on 15th
Dec 2012.
Design, diversity-oriented synthesis and biological evaluation ov novel quinolinyl 2-(2-
methylquinolinyl-3-yl)-5-aryl/alkl-1,3,4-oxadiazoles and Pyrazoles (Page No 47) R.
Venkatesham, A. Manjula, B. Vittal Rao
Conferences attended
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1) Participated in the 101st Indian Science Congress held on February 3 to 7, 2014, at University of
Jammu, Jammu, India.
2) 2nd UK-India MedChem Congress 22-23 March, 2013 at CSIR-I.I.C.T, Hyderabad, India.
3) National Seminar on “Recent Advances in Green Chemistry Aligning Science, Education,
Industry & Society” (RAIGC-2010) on 15th
& 16th
November 2010 at Department of chemistry,
Satavahana University, Karimnagar, India.
MEMBERSHIP
1) Member of Indian Science Congress for the year of 2014.
HIGHLIGHTS OF THE WORK
1) Design, diversity-oriented synthesis and structure activity relationship studies of
quinolinyl heterocycles as antimycobacterial agents
Bedaquiline and isoniazide hybridized C3 substituted quinolinyl heterocycles were
synthesized in multi steps by using diversity-oriented synthesis (DOS). Thus, synthesized
compounds were evaluated for antimycobacterial activity against M.smegmatis strain. Preliminary
screening resulted three active hits namely, quinolinyl 2,5-disubstituted 1,3,4-oxadiazole,
quinolinyl pyrazole and pyrzoline which are isoniazide hydrazide incorporated heterocycles. Thus,
obtained hit moieties were successfully extended for library generation and evaluated for
antimycobacterial activity against M.smegmatis strain. In all, 40 compounds were tested for
antimycobacterial activity and 20 active molecules and 3 promising compounds were observed.
Among this series quinolinyl pyrazole showed very effective MIC (mg/mL) of M.Smegmaties
strain.
2) Quinolinyl heterocycles as antimycobacterial agents: Towards structure optimization of
the active analogues 2-methyl-3-(1H-pyrazol-5-yl)quinoline and 3-(5-(2-methylquinolin-
3-yl)-1,3,4-oxadiazol-2-yl)-4H-chromen-4-one
Inspired by the earlier report, structure optimization of 3-(5-(2-methylquinolin-3-yl)-
1,3,4-oxadiazol-2-yl)-4H-chromen-4-one and 2-methyl-3-(1H-pyrazol-5-yl)quinoline was under
taken. In the case of 3-(5-(2-methylquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-4H-chromen-4-one the
scope for further extension is limited, so a reverse synthetic approach was adopted which provides
the two synthetic routes. Among them hydrazones are well known antitubercular agents and taken
for further extension. Diverse functional groups were assembled around the privileged scaffold
i.e., 2-methyl-3-(1H-pyrazol-5-yl)quinoline including a series of 1,4-disubstituted 1,2,3-triazole
derivatives, which were synthesized under Huisgen 1,3-cyclo addition conditions. The
synthesized compounds were evaluated for antitubercular activity against M. smegmatis strain. In
all 40 compounds were tested, wherein 14 active compounds were obtained. Four of these
compounds that were found to be promising in antitubercular screening also exhibited an added
asset of low cytotoxicity.
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3) Synthesis and antimicrobial and anti-inflammatory evaluation of 2-(2-methylquinolin-3-
yl)-5-aryl/alkyl, hydrazones and 1,3,4-oxadiazoles Above synthesized quinolinyl hydrazones, oxadiazoles have been evaluated for
antimicrobial (against five gram+ve, five gram-ve, four fungal strains) and anti-inflammatory
activity. Many compounds displayed good antimicrobial activity with a minimum inhibitory
concentration (MIC) on both five gram negative and gram positive bacteria. Some of the
synthesized compounds are inhibited the growth of bacterial and fungal starains more than the
standard. Especially quinolinyl hydrazones shown appreciable antimicrobial activity. 2,5-
Disubstituted 1,3,4-oxadiazole are shown their promising anti-inflammatory activity at different
intervals.
4) (Bromodimethylsulfonium) bromide catalyzed solvent free Friedlander synthesis of
substituted quinolines
A simple and efficient (Bromodimethylsulfonium) bromide catalyzed synthesis of
quinolines, bycondensation of α-amino carbonyl, that is, 2-aminobenzophenone and 2-
aminoacetophenone with α-methylene containing carbonyl like 1,3-dicarbonyls has been
developed. The reaction is versatile, solvent free protocol for generation of structurally diverse
quinolines.
5) (Bromodimethylsulfonium) bromide Catalyzed One-Pot Three-Component Synthesis of
Imidazo[1,2-a]pyridines
(Bromodimethylsulfonium) bromide catalyzed one-pot multicomponent reaction of 2-
aminopyridine with aromatic aldehyde(s) and TMSCN yielding N-benzylidene-2-
phenylimidazo[1,2-a]pyridines exclusively has been described. The reaction is solvent free,
versatile, and takes significantly short time.
PERSONAL DATA
Nationality : Indian
Date of birth : 14 March 1984
Sex : Male
Marital Status : Un married
PERMANENT ADRESS
Venkatesham Rachakonda
Panchavati Colony
H. No: 5-55/25
Medipally
Ranga Reddy
Hyderabad
508 285
REFERENCES
Dr. Alla Manjula
Principal Scientist
Crop Protection Chemicals Division (CPC)
CSIR-Indian Institute of Chemical Technology (CSIR-IICT)
5
Uppal Road, Tarnaka
Hyderabad, India.
E-mail: [email protected], or [email protected]
Dr. M. Vijjulatha
Associate Professor
Molecular Modeling and Medicinal Chemistry Group
Univesity College of Science
Osmania University
Tarnaka
Hyderabad, India.
E-mail: [email protected]
Dr. Bommena Vittal Rao
Retired Chief Scientist
Crop Protection Chemicals Division (CPC)
CSIR-Indian Institute of Chemical Technology (CSIR-IICT)
Uppal Road, Tarnaka
Hyderabad, India.
E-mail: [email protected]
Dr. Ummanni Ramesh
Scientist
Centre for Chemical Biology
CSIR-Indian Institute of Chemical Technology (CSIR-IICT)
Uppal Road, Tarnaka
Hyderabad, India.
E-mail: [email protected]
