ROSWELL PARK CANCER INSTITUTE’S Cancer Research … · 2019. 10. 25. · Roswell Park Cancer Institute in Buffalo, N.Y. is America's ﬁrst cancer center and ... The internship

ROSWEL L PARK CANCER I N S T I T U T E ’ S

Cancer Research Experience Program

Opportunities forHoward University Students

1

THE ROSWELL PARK/HOWARD UNIVERSITY CANCER SCHOLARS PROGRAM

Roswell Park Cancer Institute in Buffalo, N.Y. is America's first cancer center and

a National Cancer Institute-designated Comprehensive Cancer Center conducting

clinical care, research, education, and community outreach. The mission of Roswell

Park Cancer Institute is to “understand, prevent, and cure cancer.”

Howard University students accepted into the one of the Roswell Park Internship Programs will:

• deeply explore their interest in cancer under the direction of active researchers at a leading

Comprehensive Cancer Center;

• prepare for graduate education in the cancer sciences by reading cutting-edge scientific

literature, participating in an intensive hands-on research experience, developing scientific

communication skills, and experiencing the “bench-to-bedside” continuum of modern

translational research;

• understand and become empowered to address issues of cancer health disparity in

African-American and other underserved communities; and

• learn about the variety of career pathways and research areas within the cancer team, such as

prevention, epidemiology, cancer biology, therapeutics development and clinical research.

RI

TM

TM

2

School Year Research Tele-mentorship:Howard University students participate in an academic year tele-mentorship with an RPCI faculty

research member. Students will read scientific literature relevant to the Roswell Park investigator’s

field of study, including publications from their laboratory. Students will discuss these readings weekly

for one hour via video chat with the Roswell Park faculty or graduate students and postdoctoral fellows

in their labs. Students will be prepared through this pre-internship learning module to readily integrate

background knowledge into their summer research internship and be productive in their research project.

Summer Research Experience Program in Cancer Science Internship: Common to all three research experience programs is the “Summer Research Experience Program

in Cancer Science.” This is a 10-week summer research internship program hosted at Roswell

Park Cancer Institute. Students conduct a research project under the mentorship of their RPCI research

faculty member and his/her laboratory staff. This core research experience is supported by curricular and

professional development activities. The internship culminates in a cap-stone scientific talk and poster

on the intern’s summer research project which they present to their fellow interns, faculty and staff

at a concluding program-wide summer scientific conference.

ROSWEL L PARK CANCER I N S T I T U T E ’ S C ANCER R E S EARCH E XP ER I ENCE PROGRAMS :

Howard Cancer Scholars Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3For Honors Program Sophomores interested in cancer science

Howard Prostate Cancer Scholars Program . . . . . . . . . . . . . . . . . . . . . . . 5For Honors Program Sophomores and non-Honors Juniors interested in prostate cancer science

Summer Research Experience Program in Cancer Science. . . . . . . . . . . 7For Juniors interested in cancer science

Mentor Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

TM

RI

RI

RI

3

PROGRAM OV ERV I EW :

Howard Cancer Scholars Program: Funded by National Institutes of Health (R25CA181003)Howard University Sophomores enrolled in the Honors Program and majoring in biology can explore

a cancer topic in the field of expertise of a Roswell Park Cancer Institute (RPCI) faculty researcher

across a variety of disciplines: cancer cellular and molecular biology, cancer biophysics, cancer

epidemiology, cancer pharmacology/therapeutics or tumor immunology. Accepted Scholars develop

an understanding of their selected research topic through mentored directed readings in preparation

for conducting their own project in an immersive funded summer research internship experience.

An Honors student successfully completing this program will satisfy Howard University’s Honors

requirements and will be able to make an informed decision and competitive application to enter

a graduate school in preparation for a career in cancer research. Funding support is provided by the

National Institutes of Health (R25CA181003.)

E L I G I B I L I T Y R EQU I R EMENTS :

HOWARD CANCER S CHOLARS PROGRAM

Mentors Available in Any Cancer Field

Who May Apply Sophomore Honors Students

When To Apply November of Sophomore Year

Citizenship U.S. or Permanent Resident of the U.S.

Pre-Internship 3 Semesters of Tele-Mentored Directed Readings I-III Courses Beginning Spring of Sophomore Year

Internship 10-week Summer Research Internship at Roswell Park between Junior and Senior years

Post-Internship Use summer research as basis for writing an Honors Thesis

Funding $4000 subsistence allowance

Application Deadline November 14, 2014

Details & Application RoswellPark.edu/education/summer-programs/cancer-scholars-application

4

1. SOPHOMORE FALL APPLICATION, SELECTION ANDPLACEMENT

2. SOPHOMORE SPRINGTELE-MENTOREDDIRECTED READINGS I

2. JUNIOR FALL TELE-MENTOREDDIRECTED READINGS II

2. JUNIOR SPRINGTELE-MENTOREDDIRECTED READINGS III

3. JUNIOR SUMMERPAID RESEARCHINTERNSHIP ATROSWELL PARK

4. SENIOR YEARPRESENTATION AT SCIENCE

CONFERENCE ANDHONORS THESIS

Apply online by, November 14, 2014

Identify which mentors match your interests.

Roswell Park and Howard University faculty will placefive Cancer Scholars and match them to mentors.

Complete Directed Readings I, II, and III courses under the tele-mentorship of Roswell Park research faculty.

Read scientific literature relevant to the Roswell Park mentor’s field of study, including publications from their laboratory.

Discuss these readings weekly for one hour via video chat with the Roswell Park faculty or graduate students and postdoctoral fellows in their labs.

Upon satisfactory completion of the Directed Readings courses: - Admitted into Roswell Park’s summer research program. - Conduct your honors research project with your mentor.- Present a cap-stone scientific talk and poster on your summer research project to intern peers.

Present an Honors Thesis based on your Roswell Park research.

fPROGRAM TRACK :

Summer Internship Funding: You will receive a subsistence allowance of $4000 to cover your summer living expenses and lodging expenses at Canisius College dormitories for the 10 week duration of the program.Payments are made to interns on a bi-weekly basis during the summer internship period.

PROGRAM OV ERV I EW :

Howard Prostate Cancer Scholars Program:Funding support is provided by the Department of Defense (PC131811.)African American men are more likely to develop more aggressive forms of prostate cancer, have

earlier on-set of the disease and succumb to the disease at a higher rate than Caucasians. Howard

University Sophomores enrolled in the Honors Program or non-Honors Juniors majoring in biology

can select to be mentored by an RPCI Faculty researcher with prostate cancer expertise to conduct

an in-depth learning and research experience on prostate cancer which includes a focus on underlying

biological racial disparities in disease diagnosis and treatment. Accepted Scholars develop an

understanding of their selected prostate cancer research topic through school year tele-mentorship

with their RPCI Faculty researcher. These tele-mentored readings will satisfy course requirements of

the “Directed Readings (I-III)” for Honors students and “Topics in Cell and Molecular Biology” for

non-Honors students. Completion of the tele-mentored readings phase prepares students for a funded

summer research experience in their mentor’s laboratory at Roswell Park where they will work on

their own research project. Students will present a poster of their summer research at a national

conference in their Senior year and receive continued mentorship. Honors students can satisfy Howard

Honors requirements by completing all phases of this program. After his/her research experience,

a Prostate Cancer Scholar is poised to enter a graduate training program and pursue a career in

prostate cancer. Funding support is provided by the Department of Defense (PC131811.)

5

6

HOWARD PROSTAT E CANCER S CHOLARS PROGRAM

Mentors Available in Prostate Cancer

Who May Apply Sophomore Honors Students Juniors (2014-2015 only)

When To Apply November of Sophomore Year November of Junior Year


Pre-Internship3 Semesters of Tele-Mentored Directed Readings

I-III Courses Beginning Spring of Sophomore Year

1 Semester of Tele-Mentored Topics in Cell

and Molecular Biology in Spring of Junior Year

Internship 10-week Summer Research Internship at Roswell Park between Junior & Senior years

Post-InternshipUse summer research as basis for writing an

Honors Thesis. Present research at national

scientific meeting

Present research at national scientific meeting

Funding $6000 stipend

Application Deadline November 14, 2014

Details & Application RoswellPark.edu/education/summer-programs/cancer-scholars-application


7

PROSTAT E CANCER S CHOLAR PROGRAM

1. SOPHOMORE FALL APPLICATION, SELECTION ANDPLACEMENT

2. SOPHOMORE SPRINGTELE-MENTOREDDIRECTED READINGS I

2. JUNIOR FALL TELE-MENTOREDDIRECTED READINGS II

2. JUNIOR SPRINGTELE-MENTOREDDIRECTED READINGS III


4. SENIOR YEARPRESENTATION AT SCIENCE



Identify which prostate cancer mentors match your interests.


Complete Directed Readings I, II, and III courses under the tele-mentorship of Roswell Park research faculty.


Discuss these readings weekly for one hour via video chat with the Roswell Park faculty or graduate students and postdoctoral fellows in their labs.

Upon satisfactory completion of the Directed Readings courses: - Admitted into Roswell Park’s summer research program. - Conduct your honors research project with your mentor.- Present a cap-stone scientific talk and poster on your summer research project to intern peers.

Write & Present an Honors Thesis based on your research.

Present your research at a national scientific conference

Receive extended advisement from their RPCI faculty mentor on: - preparation of your research poster- preparation of graduate school applications and interviewing for graduate programs.

f

Summer Internship Funding: You will receive a stipend of $6000 to cover your summer living expenses and lodging expenses at Canisius College dormitories for the 10 week duration of the program.Payments are made on a bi-weekly basis during the summer internship period.

PROGRAM TRACK : S OPHOMORE HONORS B I O LOGY MAJORS

8

PROSTAT E CANCER S CHOLAR PROGRAM

APPLICATION, SELECTION ANDPLACEMENT

1. JUNIOR FALL

2. JUNIOR SPRING

TELE-MENTOREDDIRECTED READINGS III

3. JUNIOR SUMMER

PAID RESEARCHINTERNSHIP ATROSWELL PARK

4. SENIOR YEAR

PRESENTATION AT SCIENCE





Complete “Topics in Cellular and Molecular Biology” courseunder the tele-mentorship of Roswell Park research faculty.


Upon satisfactory completion of the

“Topics in Cellular and Molecular Biology”:- Admitted into Roswell Park’s summer research program. - Conduct your honors research project with your mentor.- Present a cap-stone scientific talk and poster on your summer research project to intern peers.

Present your research at a national scientific conference

Receive extended advisement from their RPCI faculty mentor on: - preparation of your research poster- preparation of graduate school applications and interviewing for graduate programs.

f

PROGRAM TRACK : NON -HONORS J UN I OR B I O LOGY MAJORS

Summer Internship Funding: You will receive a stipend of $6000 to cover your summer living expenses and lodging expenses at Canisius College dormitories for the 10 week duration of the program.Payments are made on a bi-weekly basis during the summer internship period.

9

PROGRAM OV ERV I EWS :

Summer Research Experience Program in Cancer Science: Funding support is provided by the National Institutes of Health (R25CA181003.)Undergraduate biology/science majors enrolled in their junior year at colleges nationwide may choose

to explore a cancer topic at RPCI in one of several disciplines: cancer cellular and molecular biology,

cancer biophysics, cancer epidemiology, cancer pharmacology/therapeutics or tumor immunology.

Accepted students receive a funded summer research internship experience in the laboratory of

a selected RPCI faculty researcher. Interns attend curricular and professional development activities

as part of a formal program to support their core research experience. After his/her summer research

experience, an intern is able to make an informed decision and competitive application to graduate

school in preparation for a career in cancer research. This program is not specific to Howard University

students; rather Howard applicants compete within a national applicant pool. Funding support is

provided by the National Institutes of Health (R25CA181003.)


SUMMER R E S EARCH E XP ER I ENCE PROGRAM I N CANCER S C I ENCE

Mentors Available in Any Cancer Field

Who May Apply Juniors

When To Apply January of Junior Year


Pre-Internship None

Internship 10-week Summer Research Internship at Roswell Park between Junior and Senior years

Post-Internship None

Funding $4000 subsistence allowance

Application Deadline January 10, 2015

Details & Application RoswellPark.edu/education/summer

10

THE ROSWELL PARK/HOWARD UNIVERSITY CANCER SCHOLARS PROGRAM

APPLICATION, SELECTION ANDPLACEMENT

2. JUNIOR SPRING


Apply online by, January 10, 2015


The Department of Educational Affairs at Roswell Park Cancer

Institute finalizes placement of 20 funded internships froma national pool of applicants.

Students admitted to the “Summer Research Experience Program in Cancer Science.”

Present your research at a local scientific conference

f

Summer Internship Funding: You will receive a subsistence allowance of $4000 to cover your summer living expenses and lodging expenses at Canisius College dormitories for the 10 week duration of the summerinternship program. Payments are made to interns on a bi-weekly basis during the summer internship period.

Summer Research Experience Program in Cancer Science: P ROGRAM TRACK :

9

MENTOR D I R EC TORY

Available mentors and their research profiles: The following Roswell Park Cancer Institute researchers have volunteered to participate as mentors to

Howard University students accepted into the “Howard Prostate Cancer Scholar” and “Howard Cancer

Scholar” programs. These mentors and their laboratory staff will tele-mentor on pertinent scientific

literature, supervise the summer research internship and provide extended mentoring activities.

Mentors in the directory are categorized by their department affiliation. Highlighted in each mentor’s

profile is their availability to serve as a mentor in the “Howard Prostate Cancer Scholars Program”

or “Howard Cancer Scholars Program.” Eligible Howard students will indicate on the application

the program for which they wish to be considered: “Howard Cancer Scholars,” “Howard Prostate

Cancer Scholars” or both.

• Students applying to ONLY the “Howard Cancer Scholars” program may indicate on the

application their preferences for any mentors listed as “Available to mentor in the Howard

Cancer Scholars Program.”

• Students applying to ONLY the “Howard Prostate Cancer Scholars” program must indicate

on the application their preferences ONLY for mentors listed as “Available to mentor in the

Howard Prostate Cancer Scholars Program.”

• Students applying to BOTH the “Howard Cancer Scholars” and “Howard Prostate Cancer

Scholars” should indicate at least TWO preferred mentors from among those listed as

“Available to mentor in the Howard Prostate Cancer Scholars Program.”

Note: A Directory of Mentors for the “Summer Research Experience Program in Cancer Science” is not included

here but will be available on-line (www.roswellpark.edu/education/summer) beginning in December after mentors

have registered.

Available to mentor in the Howard Cancer Scholars ProgramAvailable to mentor in the Howard Prostate Cancer Scholars Program

CS

PS

10

CANCER PR EV ENT I ON AND POPU LAT I ON S C I ENCES


Lara Campbell, PhDAssistant Professor

Department of Cancer Prevention and ControlDivision of Cancer Prevention and Population Sciences

Member, Graduate FacultyRoswell Park Graduate Division, University at Buffalo

Research Interests: My research aims to establish a genome-wide under-standing of how miRNA contribute to prostate cancer progression and the healthdisparity observed in prostate cancer of African American men using prostatecancer tissue specimens.

Chi-Chen Hong, PhDAssistant Member

Department of Cancer Prevention and ControlDivision of Cancer Prevention and Population Sciences

Research Interests: Our research is largely focused on breast cancer etiology, survivorship, and prognosis. Specifically, my interests are on the influence of lifestyle, comorbidity, genetics, and immune factors on breastcancer outcomes. We have an ongoing prospective cohort study of early stage breast cancer patients to examine issues in breast cancer survivorship,and with colleagues at the Rutgers Cancer Institute of New Jersey and Rutgers University, we have a study examining the role of obesity, related comorbidities, and their management on quality-of-life and breast cancer survival among African American women who generally demonstrate worseprognosis compared to women of other races diagnosed with breast cancer.

James Marshall, PhDSenior Vice President& Chair

Department of Cancer Prevention and Population SciencesMember, Graduate Faculty, Roswell Park Graduate Division

Research Interests: I am principal investigator of a randomized clinical trialof diet change on cancer progression among men with low grade, low volumeprostate cancer. The trial has now randomized 360 men, toward our goal of460. Each man is followed for two years after enrollment. The measures ofcancer progression include increased prostate-specific antigen (PSA), increasein the trajectory of PSA, increased tumor volume, and increased tumor grade.We have already shown that we can alter dietary practice among prostatecancer patients; this trial will show whether it makes any difference.

CS PS

CS

CS PS

11


IMMUNOLOGY

Kelvin Lee, MD Professor of Oncology and Jacobs Family Chair

Department of ImmunologyVice Chair, Department of MedicineChair, PhD Program in Immunology

Roswell Park Graduate Division, University at Buffalo

Research Interests: Our laboratory is focused on 2 main areas of investiga-tion: 1). Understanding the molecular interactions with the microenvironmentthat support the survival of normal plasma cells and their malignant counterparts– multiple myeloma cells and 2). The mechanisms that regulate dendritic cell(DC) differentiation in normal and cancer settings. Solving these problems is essential for development of new therapies which can treat malignancies suchas multiple myeloma and several other cancers.

Eunice S. Wang, MD Associate Professor and Staff Physician

Leukemia Service, Department of Medicine Assistant Member, Tumor Immunology Program

Departments of Medicine and ImmunologyMember, Graduate Faculty


Research Interests: Our laboratory focuses on the role of the tumor microenvironment in promoting the growth of hematological malignancies,specifically the role of hypoxia and vasculature. Our research involves screening of novel biological agents in clinically relevant human leukemiamodels and development of early stage clinical trials.”

CS

CS

12

CE L L AND MOL ECU LAR B I O LOGY


Irwin Gelman, PhD, Professor of Oncology and John and Santa Palisano Chair

Department of Cancer GeneticsChair, PhD Program in Molecular and Cellular Biology

Research Interests: Our general interests in prostate cancer are in the genes that specifically control metastatic behavior and clinical recurrence after androgen-deprivation therapy, essentially what is thelethal phenotype of the disease. We use genetic screening models suchas genomic shRNA libraries to identify potentially new metastasis-controlling genes, cell culture, xenograft and transgenic mouse models to validate and characterize these genes, and genomic analyses such as RNA-seq and androgen-receptor chromatin immunoprecipitation(ChIP)-seq to analyze how these genes affect disease progression.

Shahriar Koochekpour, PhDAssociate Professor of Cancer Genetics, Urology and Oncology

Departments of Cancer GeneticsMember, Graduate Faculty


Research Interests: My lab is investigating the molecular mechanismsunderlying prostate cancer aggressiveness, resistance to anti-androgentherapies, and inter-racial health disparities at both basic and transla-tional research levels. To address these aims, we use different cell andmolecular biology methodologies.

CS PS

CS

13


MOLECU LAR PHARMACOLOGY AND T H ERAPEUT I C S

Moray Campbell, PhD Associate Professor of Oncology

Department of Pharmacology and TherapeuticsMember, Graduate Faculty

Roswell Park Graduate Program, University at Buffalo

Research Interests: My research aims to establish a genome-wide understanding of how miRNA contribute to prostate cancer progression and the health disparity observed in prostate cancer of African American men using prostate cancer tissue specimens.

Dhyan Chandra, PhDAssociate Professor of Oncology



Research Interests: The research focus of Dr. Chandra’s laboratory is to identify and define various mitochondrial regulators of prostate cancer cell death. He also investigates the underlying mechanisms of prostate cancer health disparities among African American and European Americanmen. The ultimate goal of his laboratory is to develop effective agents for prostate cancer therapy by targeting mitochondria.

Barbara Foster, PhDAssociate Professor of Oncology


Roswell Park Graduate Program, University at Buffalo

Research Interests: My lab is interested in determining how nuclear steroid receptors lose their anti-cancer activity in advanced disease.This basic research will form the platform to design better strategies for intervention and identify patients most/least likely to benefit from nuclear receptor-based therapy.

CS PS

CS PS

CS PS

14



David Goodrich, PhDProfessor of Oncology

Departments of Pharmacology and TherapeuticsMember, Graduate Faculty


Research Interests: My lab is interested in identifying and characteriz-ing the molecular alterations that drive the progression of benign prostatecancer to metastatic and potentially lethal disease. We use molecular andgenetic experimental approaches, particularly genetically engineeredmouse models, to study how changes in normal regulatory pathwayscontribute to prostate cancer phenotypes. Our recent work has focusedon RNA processing factors and how they may be used to predict the like-lihood of prostate cancer progression.

Wendy Huss, PhDPrinciple Investigator of DoD

“Howard Prostate Cancer Scholars Program”Associate Professor of Oncology



Research Interests: The major focus of my lab is to determine the roleof cancer stem cells in prostate cancer progression and how cancer stemcells may be a therapeutic target.

CS PS

CS PS

15



Mukund Seshadri, DDS, PhDAssociate Professor of Oncology



Research Interests: One of the ongoing projects in the laboratory is focusedon investigating the therapeutic potential of a novel combination strategy forcastration-resistant metastatic prostate cancer (CRMPC). The high mortality rate associated with CRMPC underscores the critical need to investigate noveltreatment approaches that can improve response rates in this patient population.Using clinically-relevant models, the research project will address several key questions of critical importance to the successful clinical translation of this approach. To determine the translational potential of this combination strategy for prostate cancer, we will conduct imaging-guided preclinical trials to characterize the vascular response of tumors to combined androgen deprivation and vascular-targeted therapy. The work is interdisciplinary in nature and draws on concepts from biophysics, cancer biology, pharmacology,molecular biology and clinical oncology.

Anna Woloszynska-Read, PhDAssistant Professor of Oncology



Research Interests: Focusing on genitourinary malignancies, my workmerges basic and translational research. My group’s goal is to understand thegenetic landscape of invasive bladder cancer in order to enhance biologicalknowledge of the malignancy, and to point to novel strategies for diagnosticsand treatment. I also focus on cancer health disparities in prostate cancer.Specifically, I am interested in the role of DNA methylation and vitamin D deficiency in aggressiveness of prostate cancer among African-American men.

CS PS

CS PS

16

UROLOG I C ONCOLOGY


Hannelore Heemers, PhDAssistant Professor, Department of UrologyMember, Graduate Faculty


Research Interests: The standard of care for patients who suffer from non-organ confined prostate cancer (CaP) is androgen deprivationtherapy (ADT). Currently, ADT limits the availability of ligand for androgenreceptor (AR) or interrupts AR-ligand interaction. Both forms of ADT induceremission, but are not curative and are associated with severe side effects. The Heemers laboratory explores whether interference with themolecular regulation of AR-dependent transcription and the action of ARtarget genes may lead to novel, more CaP-specific selective forms of ADT

James Mohler, MDAssociate Director and Senior-Vice President

for Translational ResearchDepartment of Urology

Research Interests: Dr. Mohler is a clinician-scientist. His practice focuses upon prostate cancer and robot-assisted laparoscopic surgery.His laboratory focuses upon the role of the androgen receptor in racialdifferences in prostate cancer aggressiveness and prostate cancer recurrence during androgen deprivation therapy. He has authored or co-authored more than 250 publications and book chapters and a book“Androgen Action in Prostate Cancer.”

Roberto Pili, MDChief, Genitourinary ProgramProfessor of Oncology, Department of MedicineMember, Graduate Faculty


Research Interests: My laboratory tests novel epigenetic drugs inmodels of prostate cancer.

CS PS

CS PS

CS PS

28232 (9/14)

Elm & Carlton Streets | Buffalo, New York 14263www.RoswellPark.org

1-877-ASK-RPCI (1-877-275-7724)

A National Cancer Institute-Designated Comprehensive Cancer Center | A National Comprehensive Cancer Network MemberA Blue Distinction Center for Complex and Rare Cancers® | A Blue Distinction Center for Transplants® | An ANCC Magnet®-Designated Hospital

FUNDING SUPPORT:

The “Howard Cancer Scholars Program” and the

“Summer Research Experience Program in Cancer Science”

are supported by funding from the National Cancer Institute of the

National Institutes of Health under award number: R25CA181003.

The “Howard Prostate Cancer Scholars Program” is supported by funding

from the Department of Defense under award number: PC131811

Documents

ROSWELL PARK CANCER INSTITUTE’S Cancer Research … · 2019. 10. 25. · Roswell Park Cancer Institute in Buffalo, N.Y. is America's ﬁrst cancer center and ... The internship