KHAIRUDDIN DJAWAD

Chronic disease Pilosebaceous unit Location: central face Capillary hyperactivity

Age : 30 – 50 years old

peak age: 40 – 50 years old

Sex : Female : male = 3 : 1

but men are prone to rhinophyma more than women

Race : Caucasian and Northern Mediterranian

Vascular Hyperactivity

Heat

Helicobacter pylori

Demodex folliculorum

Propionibacterium acnes

Menopause

Parkinson Disease

Drugs

Vascular Instability

Cytokine Release

Inflammation

Immunitary System Activation

Demodex folliculorum

Food

Emotional Stress

Vasoactive Substances

HormonesVascular Hyperactivity

Sun Exposure

Tissue Damage

Granulomatous Rosace

Rosacea Conglobata

Rosacea Fulminans

Bacterial Culture

Skin Biopsy

Erythematelangiotatic: superficial perivascular lymphohistiocytic infiltrate and telangecsia.

Papulopustular: chronic nonspecific infiltrate, usually on perifollicular area.

Phymatous: increased quantity and size of sebaceous glands, dilatation of pilosebaceous ducts and keratin plugs.

Demodex folliculorum sometimes can be found.

SLESLE Acne Acne VulgarisVulgaris

Systemic DrugsSystemic Drugs

Topical DrugsTopical Drugs

Invasive Invasive TherapyTherapy

OthersOthers

Erythematelangiectatic

Papulopustular

Phymatous

Tetracycline HCl, oxytetracycline, doxycycline, minocycline

Erythromycin Metronidazole

Isotretinoin H. Pylori eradication therapy

Metronidazole Azelaic Acid

10% sodium sulfotenamide / 5% sulphur Erythromycin

Tretinoin D. folliculorum eradication therapy

Surgery

Laser Therapy

Ablative Therapy

Avoid Inducement Factors

Facial Massage

Other

“Disfigurement” may cause loss of confidence in the patient and inhibit their

social function.

It is a controllable disease.

What is needed:

DEDICATION by the physician and the

patient for the resolution of the

disease.