Research and Publications

Faculty name Publications

Prof. Mawieh Hamad

1. Shafarin J, K. Bajbouj, A. El-Serafy, D. Sandeep, M Hamad. 2016. Estrogen-

dependent downregulation of hepcidin synthesis induces intracellular iron efflux in

cancer cells in vitro. Biol Med 2016, 8:7.

2. Hamad M, Bajbouj K. 2016. The re-emerging role of iron in infection and immunity.

Integr Mol Med, 3(5): 807-810. DOI: 10.15761/IMM.1000251

3. Bajbouj K, M Abdulla, J Shafari, M Hamad. 2017. Estrogen-induced oxidative

stress and apoptosis in breast cancer cells is dependent the upregulation of ferritin and

enhanced iron storage. Tumor Biology 39 (10):1010428317726184, doi:

10.1177/1010428317726184.

4. Hamad M. J Shafarin, H Allam, M. Madkour, S. Awadallah A. El-Serafy, D.

Sandeep. 2017. Elevated levels of estrogen suppress hepcidin synthesis and enhance

serum iron availability in premenopausal women. (In Press, Experimental and Clinical

Endocrinology & Diabetes)

5. Bajbouj K., J. Shafarin, M. Hamad. 2017. Treatment with deferoxamine disrupts

intracellular iron homeostasis and leads to toxic effects in breast cancer cells: An in vitro

study. (Accepted; Technology in Cancer Research & Treatment)

6. K. Abu Elteen and M. Hamad. 2017. Antifungal Compounds for Use in Human

Therapy, (Chapter 12), pp: 299-331. In: Fungi: Biology and Applications 3rd

Ed., Kevin

Kavanagh, Ed., ISBN: 978-1-119-37432-9; Wiley, New York, USA & London, UK.

7. Hamad M., K. Abu Elteen and. 2017. Immunity to human fungal infections: an

update, (Chapter 11), pp: 275-298. In: Fungi: Biology and Applications 3rd

Ed., Kevin

Kavanagh, Ed., ISBN: 978-1-119-37432-9; Wiley, New York, USA & London, UK.

Prof. Samir Awadallah

1. Hayder Hassan, Amita Attlee, Veena Raigangar, Mohammed Madkour, Samir

Awadallah. Proprotein convertase subtilisin/kexin type 9 (PCSK9) and Metabolic

syndrome components among young adult females. Diabetes Metab Syndr. 2017 Mar 6.

doi: 10.1016/j.dsx.2017.03.012. [Epub ahead of print]

2. Samir Awadallah, Reem Al Hamidi, Esraa Abo Alwafa, Maram Hattab, Buhour

Zakkour Amna Al-Matroushi, Eslah Ahmed, and Mariam Al-Kitbi. Plasma levels of

Apolipoprotein A1 and Lecithin: Cholesterol Acyltransferase in type 2 Diabetes

Mellitus: Correlations with haptoglobin phenotypes Diabetes Metab Syndr. 2017 Apr 7.

doi: 10.1016/j.dsx.2017.04.001. [Epub ahead of print]

3. Hamad M. J Shafarin, J Sundaram, H Allam, M. Madkour, S. Awadallah, A. El-

Serafy, D. Sandeep. Elevated levels of estrogen suppress hepcidin synthesis and enhance

serum iron availability in premenopausal women", Exp Clin Endocrinol Diabetes 2018

Feb 2. doi: 10.1055/s-0043-124077. [Epub ahead of print]

Dr. Wael Hassan

1.Alam F, Mezhal F, El Hasasna H, Nair VA, Aravind SR, Saber Ayad M, El-Serafi A,

Abdel-Rahman WM. The role of p53-microRNA 200-Moesin axis in invasion and drug

resistance of breast cancer cells. Tumour Biol. 2017 Sep;39(9):1 -11.

1010428317714634. doi: 10.1177/1010428317714634.

2. Wael M Abdel-Rahman, Noura A. Al-khayyal, Vidhya A Nair, Aravind S.R., Maha

Saber-Ayad. Role of AXL in invasion and drug resistance of colon and breast cancer

cells and its association with p53 alterations. World J Gastroenterology. 2017,

23(19):3440-3448.

3.Abdel-Rahman WM, Faris ME, Peltomäki P. Molecular determinants of colon cancer

susceptibility in the East and West. Curr Mol Med. 2017, 17:34-45.

4. Abdel-Rahman WM, Lotsari-Salomaa JE, Kaur S, Niskakoski A, Knuutila S,

Järvinen H, Mecklin JP, Peltomäki P. The Role of Chromosomal Instability and

Epigenetics in Colorectal Cancers Lacking beta-Catenin/TCF Regulated Transcription.

Gastroenterology Research and Practice. 2016 Vol 2016: 1-11 Article ID 6089658.

5. Joensuu EI, Nieminen TT, Lotsari JE, Pavicic W, Abdel-Rahman WM, Peltomäki P.

Methyltransferase expression and tumor suppressor gene methylation in sporadic and

familial colorectal cancer. Genes Chromosomes Cancer. 2015 Dec;54(12):776-87.

6. Nieminen TT, O'Donohue MF, Wu Y, Lohi H, Scherer SW, Paterson AD, Ellonen P,

Abdel-Rahman WM, Valo S, Mecklin JP, Järvinen HJ, Gleizes PE, Peltomäki P.

Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to

Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair

Deficiency. Gastroenterology 2014 Sep;147(3):595-598.e5.

Dr. Mohamad

Hamad

1. Fathy Mohamad Y, Hamad M, Ortega XP, Valvano MA.

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in

Burkholderia cenocepacia. Molecular Microbiology. 2017 Jan 13.

2. Di Lorenzo F, Kubik Ł, Oblak A, Lorè NI, Cigana C, Lanzetta R, Parrilli

M, Hamad MA, De Soyza A, Silipo A, Jerala R, Bragonzi A, Valvano MA, Martín-

Santamaría S, Molinaro A.

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2

(MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate

of Burkholderia cenocepacia. Journal of Biological Chemistry. 2015 Aug 28;

290(35):21305-21319.

3. Schmerk CL, Welander PV, Hamad MA, Bain KL, Bernards MA, Summons RE,

Valvano MA

Elucidation of the Burkholderia cenocepacia hopanoid biosynthesis pathway uncovers

functions for conserved proteins in hopanoid-producing bacteria.

Environmental Microbiology. 2015 Mar 17:735-750.

Dr. Mohammad

Ghaleb

1. Hamad M., Mohammad G Mohammad, K. Abu Elteen and. 2017. Immunity to

human fungal infections: an update, (Chapter 11) in: Fungi: Biology and Applications 3rd

Ed., Kevin Kavanagh, Ed; Wiley, New York, USA & London, UK.

2. Samih Suleiman, Mohammad G. Mohammad, Ali A. El-Keblawi, HGany Omar,

Mohamed Abuuleish, Mohamed Madkour, Attiat Elnaggar, Racha M. Hosni. 2018.

Mechanical and phytochemical protection mechanisms of Calligonum comosum in arid

deserts. PLOS ONE. 13 (2): e0192576.

3. Sian Geldenhuys, Mohammad G Mohammad, Hui Li, Masoud Hassanpour, Royce

LX Ng, Naomi M Scott, Robyn M Lucas, David A Brown and Prue H Hart. 2015. UV

irradiation of skin regulates a murine model of multiple sclerosis. Journal of Multiple

Sclerosis. 2:3.

4. Yasmin Husaini; Glen P Lockwood; Trung V Nguyen; Vicky Wang-Wei Tsai;

Mohammad G Mohammad; Pamela J Russell; David A Brown; Sam N Breit. 2015.

Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) Gene Deletion Promotes Cancer

Growth in TRAMP Prostate Cancer Prone Mice. Plos One. 10 (2). (IF=3.234, Cited 2)

Dr. Ra’ed AbuOdeh

1. Hamadeh Tarazi, Raed Abu Odeh, Raed Al-Qawasmeh, Imad Abu

Yousef, Wolfgang Voelterf, Taleb H. Al-Tel. (2017). Design, synthesis and SAR

analysis of potent BACE1 inhibitors: Possible lead drug candidates for

Alzheimer's disease. European Journal of Medicinal Chemistry 125;1213–1224

2. Raed A. Al-Qawasmeh, Mutasem O. Sinnokrot, Mohammad H. Semreen, Raed Abu

Odeh, Musa H. Abu-Zarg, Basil Bani Huthail, Hamadeh Tarazi, Imad Abu Yousef, and

Taleb H. Al-Tel (2016).

Design, Synthesis and Qualitative Structure Activity Relationship Evaluations of

Quinoline-Based Bisarylimidazoles as Antibacterial Motifs. Medicinal Chemistry

12;563-573.

3. R.O. Abu Odeh, H. Aziz, H. Moussa, S. Hussien, T. Hadwan and G.K. Nasrallah

(2017). First study in Qatar to reveal high Legionella counts in cooling towers. Eastern

Mediterranean Health Journal

4. Maria K. Smatti, Hadi M. Yassine, Raed AbuOdeh, Asmaa AlMarawani, Sara A.

Taleb, Asmaa A. Althani, Gheyath K. Nasrallah (2017). Prevalence and molecular

profiling of EpsteinBarr virus (EBV) among healthy blood donorsfrom different

nationalities in Qatar. PLOS ONE

5. Abdelmunim Dafalla, Shaikha A. Almehari, Mohamed J. Alhosani, Meera

Yousif, Mariam I. Alkoos, Mousa AlAzzawi, Adam D. Abakar, Bakri Y. M. Nour,

Haydar Hasan, Ra’ed AbuOdeh, Ali ElBakri (2017) Intestinal Parasitic Infections

among Expatriate Workers in Various Occupations in Sharjah, United Arab

Emirates. Revista do Instituto de Medicina Tropical de São Paulo

6. Ali ElBakri, Lazarus Mogane, Sinda Ezzedine, Natasha Potgeiter, Pascal Bessong,

Raed AbuOdeh, Amidou Samie (2017). Prevalence of Cryptosporidium spp. among

asymptomatic healthy expatriate workers in Sharjah, United Arab Emirates. African

Journal of Infectious Diseases

Sondos Harfil

Wegdan Bani-issa, Kamal Eldeirawi, Sondos Harfil, and Randa Fakhry, “Vitamin D

Deficiency and Its Determinants in Adults: A Sample from Community-Based Settings

in the United Arab Emirates,” International Journal of Endocrinology, vol. 2017, Article

ID 3906306, 7 pages, 2017. doi:10.1155/2017/3906306.

Mohamed Madkour

1. Samir Awadallah, Mohammed Madkour, Reem Al Hamidi, Esraa Abo Alwafa,

Maram Hattab, Buhour Zakkour, Amna Al-Matroushi, Eslah Ahmed, Mariam Al-Kitbi

(2017): Plasma levels of Apolipoprotein A1 and Lecithin:Cholesterol

Acyltransferase in type 2 diabetes mellitus: Correlations with haptoglobin

phenotypes. Diabetes & Metabolic syndrome:Clinical Research & Reviews, 11S

(2017) S543–S546.

2. Hayder Hasan, Amita Attlee, Veena Raigangar, Mohamed Madkour and Samir

Awadallah (2017): Proprotien Convertase Substitin/ Kexin type 9 (PCSK9) and

Metabolic Syndrome components among young adult females. Diabetes &

Metabolic syndrome:Clinical Research & Reviews, 11S (2017) S337–S341.

3. Sameh Soliman*, Mohammad G. Mohammad, Ali A. El-Keblawy, Hany

Omar,Mohamed Abouleish, Mohamed Madkour, Attiat Elnaggar, Racha M. Hosni.

"Mechanical and phytochemical protection mechanisms of Calligonum comosum in

arid deserts. (2018) PLoS ONE 13(2): e0192576.

4. Khuloud Bajbouj, Jasmin Shafarin, Hilda Allam, Mohamed Madkour, Samir

Awadallah, Ahmed El-Serafy, Divyasree Sandeep, Mawieh Hamad. Elevated Levels of

Estrogen Suppress Hepcidin Synthesis and Enhance Serum Iron Availability in

Premenopausal Women. Experimental and Clinical Endocrinology & Diabetes (2018).

DOI: 10.1055/s-0043-124077

Funded Research Projects

No

. Project Title

Principal

Investigator Grant Source

Amount

(AED)

1. Evaluating the capacity of estrogen-

mediated downregulation of hepcidin

synthesis to deplete intracellular iron stores

in breast cancer cells. Aug. 2015-Aug.

2017

Mawieh

Hamad

University of

Sharjah, Sharjah,

UAE

141,600

2. Iron Biology Research Group Grant.

(2015-2016) Iron Biology Group.

Mawieh

Hamad

University of

Sharjah, Sharjah,

UAE

100,000

3. Assessing the effect of estrogen-induced

intracellular iron depletion on the

proliferation and activation potential of

human T lymphocytes. April 2016- Oct.

2016

Mawieh

Hamad

Boehringer-

Ingelheim, Dubai,

UAE.

16,000

4. Iron Biology Research Group Grant.

(2016-2017) Iron Biology Group.

Mawieh

Hamad

University of

Sharjah, Sharjah,

UAE

120,000

5. Evaluating the anti-carcinogenic potential

of biologically-driven intracellular iron

depletion. 2016 (2 years). Al-Jalila

Foundation. Principal Investigator

Mawieh

Hamad

Al-Jalila

Foundation,

Dudia, UAE

290,000

6. Molecular Study of Colon and Breast

Cancer Development in Obesity. Nov.,

2016 -2019

Wael Abdel-

Rahman

Hassan

University of

Sharjah -

University

200,000

7. Cancer and the environment research group

operational grant (2015-16)

Wael Abdel-

Rahman

Hassan

University of

Sharjah, Sharjah,

UAE

100,000

8. Cancer and the environment research group

operational grant (2016-17)

Wael Abdel-

Rahman

Hassan

University of

Sharjah, Sharjah,

UAE

100,000

9. Elucidation of cell death mechanisms of

novel molecules CP-380736 and MPT-

0B014 in colorectal and breast cancer.

Wael Abdel-

Rahman

Hassan

Boehringer

Ingelheim- UoS

Award 2017

15,000

10. Studying the phosphorylation status of

ShcD in melanoma upon oxidative stress:

An evidence for new therapeutic target in

melanoma.

P.I. Dr.

Samrein

Ahmed (CoM)

Dr Wael

Abdel-Rahman

Hassan (co-PI)

Al Jalila

Foundation 270,000

11. Predicting Colorectal Cancer Risk in

Subjects with Metabolic Syndrome in

Dr. Wael

Abdel-Rahman

Boehringer

Ingelheim- UoS 15,000

University of Sharjah Community Hassan Award 2016

12. Significance of Galanin expression on

caspase 8 –mediated apoptosis and

sensitivity to chemotherapy in colon cancer

cells.

P.I. Dr. Maha

Saber (CoM)

Dr Wael

Abdel-Rahman

Hassan (co-PI)

Boehringer

Ingelheim- UoS

Award 2016

15,000

13. Metabolic Syndrome and Related Disorders

Research Group. Group Leader, S. Awadallah

RIMHS,

University of

Sharjah

100,000

14. Assessment of Lifestyle, Anti-oxidative,

Oxidative and Inflammatory Markers in

relation to Metabolic Syndrome

components among adults in UAE.

Principal investigator.

S. Awadallah

RIMHS,

University of

Sharjah

109,000

15. Influence of haptoglobin phenotypes on the

expression of CD163 and uptake of

hemoglobin-haptoglobin complex by

macrophages. Principal investigator.

S. Awadallah

Boehringer

Ingelheim- UoS

Award

2016

19,000

16. Serum levels of Lecithin:Cholesterol

Acyltransferase (LCAT) in type 2 Diabetes

Mellitus: Correlations with concentration

and phenotypes of haptoglobin. Principal

investigator.

S. Awadallah

Boehringer

Ingelheim- UoS

Award

2016

14,000

17. TANITA Healthy Weight Community

Trust-in-Aid Sondos Harfil TANITA 34,000

18. Dubai Harvard Foundation for Medical

Research Scholarship Sondos Harfil Dubai Harvard 11,000

19. Evaluating the therapeutic potential of

microRNAs in restoring normal function

and immunoquiescence of the Blood-Brain

Barrier in multiple sclerosis (2017-2018)

Mohammad

Ghaleb (Co-

PI)

University of

Sharjah 80,000

20. Assessment of the potential of LPS-

activated human macrophages and T cells

co-cultures with dental pulp stem cells

(Dpsc) to regulate cytokine production

(2017-2018)

Mohammad

Ghaleb (Co-

PI)

University of

Sharjah 195,000

21. Dendritic cells and immunoregulation in

mice model of multiple sclerosis (Feb 2018-

2021)

Mohammad

Ghaleb

University of

Sharjah 193,000

22. The anti-tumor effects of dendritic cell

exosome secretions (Feb 2018-2021) Mohammad

Ghaleb

University of

Sharjah 80,000

23. Molecular Assessment of Dendritic Cells

Involvement in Mouse Model of Rhizopus

Brain Infection (2017-2018)

Mohammad

Ghaleb

Boehringer

Ingelheim- UoS

Award

2017

16,000

24. Phenotypic investigations of Macrophage

sub-population transitions? (2016-2017) Mohammad

Ghaleb

Boehringer

Ingelheim- UoS

Award

2016

11,500

25. Isolation and screening of environmental

microbiota native to the United Arab

Emirates for the production of novel

antibiotics and antifungals (2017-2018)

Mohamad

Hamad

Boehringer

Ingelheim- UoS

Award

2017

15,000