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J Korean Med Assoc 2011 May; 54(5): 511-520 DOI: 10.5124/jkma.2011.54.5.511 pISSN: 1975-8456 eISSN: 2093-5951 http://jkma.org ๋Œ€ํ•œ์˜์‚ฌํ˜‘ํšŒ์ง€ 511 J Korean Med Assoc 2011 May; 54(5): 511-520 Continuing Education Column c Korean Medical Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ๋‹ค์‹œ ๋‚˜ํƒ€๋‚œ ์ ˆ์ง€๋™๋ฌผ์— ์˜ํ•œ ํ”ผ๋ถ€์งˆํ™˜ โ…  : ์˜ด ์กฐ ๋ฐฑ ๊ธฐ* | ๊ฐ€ํ†จ๋ฆญ๋Œ€ํ•™๊ต ์˜๊ณผ๋Œ€ํ•™ ์—ฌ์˜๋„์„ฑ๋ชจ๋ณ‘์› ํ”ผ๋ถ€๊ณผ Reemerging skin disease caused by arthropods I: scabies Baik Kee Cho, MD* Department of Dermatology, Yeoido St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea *Corresponding author: Baik Kee Cho, E-mail: [email protected] Received February 7, 2011ยทAccepted February 23, 2011 S cabies is one of the most common world-wide arthropod-born diseases in both humans and animals caused by the โ€œitchโ€ mite Sarcoptes scabiei. The incidence of scabies has shown a tendency to increase for the last several years in Korea. The previous peak incidence in Korea was between the early 1970s and early 1980s. A substantial part of the cyclic resurgence of scabies has been considered the result of inexperience and indifference of medi- cal doctors toward the disease. The recent resurgence is presumed to be derived from not only indifference of the doctors but also an increase in elderly patients admitted to nursing homes and eldercare hospitals. Scraping using mineral oil for scabies patients is a very simple and effective method for definite diagnosis. A new diagnostic method using a dermoscope is also effective, especially for very young patients. Lindane and crotamiton are two available antisca- bietic preparations in Korea. Crotamiton is less effective, while infants and pregnant women should not use lindane. In conclusion, medical personnel should be alert coping with the resur- gence of scabies, and it is strongly suggested that other antiscabietic drugs such as permethrin, ivermectin, etc. should be made available for resistant patients in the near future in the Republic of Korea. Keywords: Scabies; Sarcoptes scabiei ; Nursing homes; Lindane; Crotamiton ์„œ ๋ก  ์˜ด ์€ ์˜ด์ง„๋“œ๊ธฐ์˜ ํ”ผ๋ถ€๊ธฐ์ƒ์— ์˜ํ•˜์—ฌ ๋ฐœ์ƒ๋˜๋Š” ์ „์—ผ์„ฑ์ด ๋งค์šฐ ๊ฐ•ํ•œ ํ”ผ๋ถ€์งˆํ™˜์ด๋‹ค. ์˜ด์€ 2,500์—ฌ ๋…„ ์ „๋ถ€ํ„ฐ ์•Œ๋ ค ์ ธ ์žˆ์—ˆ์œผ๋ฉฐ ์˜ด์ง„๋“œ๊ธฐ๋Š” 1687๋…„ Bonomo์™€ Cestoni๊ฐ€ ํ˜„ ๋ฏธ๊ฒฝ์„ ์ด์šฉํ•˜์—ฌ ์ฒ˜์Œ ๋ฐœ๊ฒฌํ•˜์˜€๋‹ค[1]. ์šฐ๋ฆฌ๋‚˜๋ผ ์˜ด ์œ ๋ณ‘๋ฅ ์€ 1960๋…„๋Œ€์— ์™ธ๋ž˜ํ™˜์ž์˜ 2% ๋‚ด์™ธ์˜€์œผ๋‚˜, 1970๋…„๋Œ€์—๋Š” 3 - 7%๋กœ ์ฆ๊ฐ€ํ•˜์˜€๊ณ , 1980๋…„๋Œ€ ์ดˆ์—๋Š” 10%๊นŒ์ง€ ์ฆ๊ฐ€ํ•˜์—ฌ ์ ˆ์ •์— ๋‹ฌํ•˜์˜€๋‹ค. 1980๋…„๋Œ€ ์ค‘๋ฐ˜ ์ดํ›„์—๋Š” ๊ธ‰๊ฒฉํžˆ ๊ฐ์†Œํ•˜๊ธฐ ์‹œ์ž‘ํ•˜์˜€์œผ๋ฉฐ 1990๋…„๋Œ€์—๋Š” 1% ๋ฏธ๋งŒ์œผ๋กœ ๊ฐ์†Œํ•˜์˜€๋‹ค[2]. ์—ฌ์˜๋„์„ฑ๋ชจ๋ณ‘์›์˜ ๊ฒฝ์šฐ 1990๋…„๋Œ€ ํ›„๋ฐ˜์—์„œ 2000๋…„๋Œ€ ์ดˆ๋ฐ˜ ๊นŒ์ง€ ์™ธ๋ž˜์ดˆ์ง„ํ™˜์ž์˜ 0.1% ๋‚ด์™ธ์˜€์œผ๋‚˜, 2006๋…„๋ถ€ํ„ฐ 2010๋…„ ์‚ฌ์ด์—๋Š” 0.6 - 1.2%๋กœ ์ฆ๊ฐ€ํ•˜๋Š” ์ถ”์„ธ๋ฅผ ๋ณด์ด๊ณ  ์žˆ๋‹ค. ์ตœ๊ทผ ์˜ด ํ™˜์ž๋Š” ๋งŽ์€ ๋‚˜๋ผ์—์„œ ์ฆ๊ฐ€ํ•˜๊ณ  ์žˆ์œผ๋ฉฐ, ์ „ ์„ธ๊ณ„์ ์œผ๋กœ ์•ฝ 3์–ต ๋ช…์ด ๊ฐ์—ผ๋œ ๊ฒƒ์œผ๋กœ ์ถ”์ •๋˜๊ณ  ์žˆ๋‹ค[3]. ์˜ด ๋ฐœ์ƒ์˜ ์ฆ๊ฐ€๋Š” ์ „์Ÿ, ๊ธฐ์•„ ๋“ฑ์œผ๋กœ ์ธํ•œ ์—ด์•…ํ•œ ์ƒํ™œํ™˜๊ฒฝ์ด ์ค‘์š”ํ•œ ์›์ธ์ด๋‚˜,

Reemerging skin disease caused by arthropods I: scabies

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Page 1: Reemerging skin disease caused by arthropods I: scabies

J Korean Med Assoc 2011 May; 54(5): 511-520DOI: 10.5124/jkma.2011.54.5.511pISSN: 1975-8456 eISSN: 2093-5951http://jkma.org

๋Œ€ํ•œ์˜์‚ฌํ˜‘ํšŒ์ง€ 511J Korean Med Assoc 2011 May; 54(5): 511-520

Continuing Education Column

c Korean Medical AssociationThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

๋‹ค์‹œ ๋‚˜ํƒ€๋‚œ ์ ˆ์ง€๋™๋ฌผ์— ์˜ํ•œ ํ”ผ๋ถ€์งˆํ™˜โ…  : ์˜ด ์กฐ ๋ฐฑ ๊ธฐ* | ๊ฐ€ํ†จ๋ฆญ๋Œ€ํ•™๊ต ์˜๊ณผ๋Œ€ํ•™ ์—ฌ์˜๋„์„ฑ๋ชจ๋ณ‘์› ํ”ผ๋ถ€๊ณผ

Reemerging skin disease caused by arthropods I: scabiesBaik Kee Cho, MD*

Department of Dermatology, Yeoido St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea

*Corresponding author: Baik Kee Cho, E-mail: [email protected]

Received February 7, 2011ยทAccepted February 23, 2011

Scabies is one of the most common world-wide arthropod-born diseases in both humans and animals caused by the โ€œitchโ€ mite Sarcoptes scabiei. The incidence of scabies has

shown a tendency to increase for the last several years in Korea. The previous peak incidence in Korea was between the early 1970s and early 1980s. A substantial part of the cyclic resurgence of scabies has been considered the result of inexperience and indifference of medi-cal doctors toward the disease. The recent resurgence is presumed to be derived from not only indifference of the doctors but also an increase in elderly patients admitted to nursing homes and eldercare hospitals. Scraping using mineral oil for scabies patients is a very simple and effective method for definite diagnosis. A new diagnostic method using a dermoscope is also effective, especially for very young patients. Lindane and crotamiton are two available antisca-bietic preparations in Korea. Crotamiton is less effective, while infants and pregnant women should not use lindane. In conclusion, medical personnel should be alert coping with the resur-gence of scabies, and it is strongly suggested that other antiscabietic drugs such as permethrin, ivermectin, etc. should be made available for resistant patients in the near future in the Republic of Korea.

Keywords: Scabies; Sarcoptes scabiei; Nursing homes; Lindane; Crotamiton

์„œ ๋ก 

์˜ด์€ ์˜ด์ง„๋“œ๊ธฐ์˜ ํ”ผ๋ถ€๊ธฐ์ƒ์— ์˜ํ•˜์—ฌ ๋ฐœ์ƒ๋˜๋Š” ์ „์—ผ์„ฑ์ด

๋งค์šฐ ๊ฐ•ํ•œ ํ”ผ๋ถ€์งˆํ™˜์ด๋‹ค. ์˜ด์€ 2,500์—ฌ ๋…„ ์ „๋ถ€ํ„ฐ ์•Œ๋ ค

์ ธ ์žˆ์—ˆ์œผ๋ฉฐ ์˜ด์ง„๋“œ๊ธฐ๋Š” 1687๋…„ Bonomo์™€ Cestoni๊ฐ€ ํ˜„

๋ฏธ๊ฒฝ์„ ์ด์šฉํ•˜์—ฌ ์ฒ˜์Œ ๋ฐœ๊ฒฌํ•˜์˜€๋‹ค[1]. ์šฐ๋ฆฌ๋‚˜๋ผ ์˜ด ์œ ๋ณ‘๋ฅ ์€

1960๋…„๋Œ€์— ์™ธ๋ž˜ํ™˜์ž์˜ 2% ๋‚ด์™ธ์˜€์œผ๋‚˜, 1970๋…„๋Œ€์—๋Š”

3-7%๋กœ ์ฆ๊ฐ€ํ•˜์˜€๊ณ , 1980๋…„๋Œ€ ์ดˆ์—๋Š” 10%๊นŒ์ง€ ์ฆ๊ฐ€ํ•˜์—ฌ

์ ˆ์ •์— ๋‹ฌํ•˜์˜€๋‹ค. 1980๋…„๋Œ€ ์ค‘๋ฐ˜ ์ดํ›„์—๋Š” ๊ธ‰๊ฒฉํžˆ ๊ฐ์†Œํ•˜๊ธฐ

์‹œ์ž‘ํ•˜์˜€์œผ๋ฉฐ 1990๋…„๋Œ€์—๋Š” 1% ๋ฏธ๋งŒ์œผ๋กœ ๊ฐ์†Œํ•˜์˜€๋‹ค[2].

์—ฌ์˜๋„์„ฑ๋ชจ๋ณ‘์›์˜ ๊ฒฝ์šฐ 1990๋…„๋Œ€ ํ›„๋ฐ˜์—์„œ 2000๋…„๋Œ€ ์ดˆ๋ฐ˜

๊นŒ์ง€ ์™ธ๋ž˜์ดˆ์ง„ํ™˜์ž์˜ 0.1% ๋‚ด์™ธ์˜€์œผ๋‚˜, 2006๋…„๋ถ€ํ„ฐ 2010๋…„

์‚ฌ์ด์—๋Š” 0.6-1.2%๋กœ ์ฆ๊ฐ€ํ•˜๋Š” ์ถ”์„ธ๋ฅผ ๋ณด์ด๊ณ  ์žˆ๋‹ค. ์ตœ๊ทผ

์˜ด ํ™˜์ž๋Š” ๋งŽ์€ ๋‚˜๋ผ์—์„œ ์ฆ๊ฐ€ํ•˜๊ณ  ์žˆ์œผ๋ฉฐ, ์ „ ์„ธ๊ณ„์ ์œผ๋กœ ์•ฝ

3์–ต ๋ช…์ด ๊ฐ์—ผ๋œ ๊ฒƒ์œผ๋กœ ์ถ”์ •๋˜๊ณ  ์žˆ๋‹ค[3]. ์˜ด ๋ฐœ์ƒ์˜ ์ฆ๊ฐ€๋Š”

์ „์Ÿ, ๊ธฐ์•„ ๋“ฑ์œผ๋กœ ์ธํ•œ ์—ด์•…ํ•œ ์ƒํ™œํ™˜๊ฒฝ์ด ์ค‘์š”ํ•œ ์›์ธ์ด๋‚˜,

Page 2: Reemerging skin disease caused by arthropods I: scabies

512 ๋‹ค์‹œ ๋‚˜ํƒ€๋‚œ ์ ˆ์ง€๋™๋ฌผ์— ์˜ํ•œ ํ”ผ๋ถ€์งˆํ™˜โ… : ์˜ด J Korean Med Assoc 2011 May; 54(5): 511-520

Cho BK

์ตœ๊ทผ ์šฐ๋ฆฌ๋‚˜๋ผ๋ฅผ ๋น„๋กฏํ•˜์—ฌ ์ค‘์ง„๊ตญ์ด๋‚˜ ์„ ์ง„๊ตญ์—์„œ์˜ ๋ฐœ์ƒ

์ฆ๊ฐ€๋Š” ๋…ธ์ธ์š”์–‘์‹œ์„ค์˜ ์ฆ๊ฐ€, ์น˜๋ฃŒ์•ฝ๋ฌผ์— ๋Œ€ํ•œ ๋‚ด์„ฑ ์ฆ๊ฐ€, ์˜

๋ฃŒ์ง„์˜ ๋ฌด๊ด€์‹ฌ๊ณผ ๊ฒฝํ—˜ ๋ถ€์กฑ์œผ๋กœ ์ธํ•œ ์กฐ๊ธฐ ์ง„๋‹จ๊ณผ ์น˜๋ฃŒ์˜ ์‹ค

ํŒจ ๋“ฑ์ด ๋งค์šฐ ์ค‘์š”ํ•œ ์š”์ธ์ธ ๊ฒƒ์œผ๋กœ ์ƒ๊ฐ๋œ๋‹ค. ์ตœ๊ทผ ๊ตญ๋‚ด ๋ณด

๊ณ ์—์„œ๋„ ์˜ด ํ™˜์ž ์ค‘ ๋…ธ์ธํ™˜์ž ๋น„์œจ์ด ๋†’์œผ๋ฉฐ[4], ํ•œ ๋…ธ์ธ์š”

์–‘์‹œ์„ค์˜ ์—ญํ•™์กฐ์‚ฌ์—์„œ๋Š” ์˜ด ํ™˜์ž์˜ ์œ ๋ณ‘๋ฅ ์ด ์ž…์†Œ์ž์˜

86%, ์ง์›์˜ 58.6%๋กœ ๋งค์šฐ ๋†’์•˜๋‹ค[5]. ๋”ฐ๋ผ์„œ 1970-1980๋…„

๋Œ€์™€ ๊ฐ™์€ ์˜ด์˜ ๋Œ€๋ฐœ์ƒ์„ ์˜ˆ๋ฐฉํ•˜๊ธฐ ์œ„ํ•ด์„œ ์˜๋ฃŒ์ข…์‚ฌ์ž์˜ ์˜ด

์— ๋Œ€ํ•œ ์˜ฌ๋ฐ”๋ฅธ ์ดํ•ด์™€ ๊ด€์‹ฌ์ด ์ ˆ์‹คํžˆ ์š”๊ตฌ๋˜๊ณ  ์žˆ๋‹ค.

์˜ด์ง„๋“œ๊ธฐ์˜ ์ƒํ™œ์‚ฌ ๋ฐ ํ˜•ํƒœ

์˜ด์ง„๋“œ๊ธฐ๋Š” ์ ˆ์ง€๋™๋ฌผ๋ฌธ(Phylum Arthropoda), ๊ฑฐ๋ฏธ์•„๊ฐ•

(Subclass Arachnida), ๋ฌด๊ธฐ๋ฌธ๋ชฉ(Order Astigmata), ์˜ด์ง„

๋“œ๊ธฐ๊ณผ(Family Sarcoptidae)์— ์†ํ•˜๋Š” ์†Œ๋™๋ฌผ์ด๋‹ค[6]. ์ง„

๋“œ๊ธฐ๋ฅ˜๋Š” ๋ชจ๋‘ ์•…์ฒด๋ถ€(gnathosoma)์™€ ๋ถ„์ ˆ๋˜์ง€ ์•Š์€ ๋™์ฒด

๋ถ€(idiosoma)๋กœ ๊ตฌ๋ถ„๋˜๊ณ  ์•ฝ์ถฉ๊ณผ ์„ฑ์ถฉ์€ 8๊ฐœ์˜ ๋‹ค๋ฆฌ๋ฅผ ๊ฐ€

์ง€๊ณ  ์žˆ๋‹ค. ์ƒํ™œ์‚ฌ๋Š” ์•Œ, ์œ ์ถฉ(larva), ์•ฝ์ถฉ(nymph), ์„ฑ์ถฉ์˜

๋‹จ๊ณ„๋ฅผ ๊ฑฐ์น˜๋ฉฐ ์œ ์ถฉ์€ ๋‹ค๋ฆฌ๊ฐ€ 6๊ฐœ์ด๊ณ  ์•ฝ์ถฉ์€ ์ˆ˜์ปท๋ณด๋‹ค ํฌ

๊ณ  ์•”์ปท๋ณด๋‹ค ์ž‘์œผ๋ฉฐ ์•”์ˆ˜๋ฅผ ๊ตฌ๋ณ„ํ•  ์ƒ์‹๊ธฐ๊ฐ€ ์—†๋‹ค[7]. ์˜ด์ง„

๋“œ๊ธฐ๋Š” ์ธ๊ฐ„์„ 1์ฐจ ์ˆ™์ฃผ๋กœ ํ•˜๋ฉฐ ์ ์ฐจ ๊ฐ€์ถ•์„ ํ†ตํ•˜์—ฌ ์•ผ์ƒ๋™

๋ฌผ์—๊นŒ์ง€ ์ „ํŒŒ๋˜์–ด ์‚ฌ๋žŒ ์™ธ์— 40์—ฌ ์ข…์˜ ๋™๋ฌผ์„ ์ˆ™์ฃผ๋กœ ํ•œ

๋‹ค. ํ•œ๊ตญ์—์„œ ๋ณด๊ณ ๋œ ์ข…์€ ์‚ฌ๋žŒ์˜ด์ง„๋“œ๊ธฐ(Sarcoptes scabiei

scabiei), ๊ฐœ์˜ด์ง„๋“œ๊ธฐ(S. canis), ๋ผ์ง€์˜ด์ง„๋“œ๊ธฐ(S. scabiei

suis)์˜ 3์ข…์ด๋‹ค. ์‚ฌ๋žŒ์˜ด์ง„๋“œ๊ธฐ๋Š” ํ”ํžˆ ์˜ด์ง„๋“œ๊ธฐ(S. sca-

biei)๋กœ ํ‘œ๊ธฐ๋˜๊ณ  ์žˆ๋‹ค[8].

์˜ด์ง„๋“œ๊ธฐ๋Š” ๋‚œ์›ํ˜•์ด๋ฉฐ ํšŒ๋ฐฑ์ƒ‰์ด๊ณ  ๋‹ค๋ฆฌ์™€ ์•…์ฒด๋ถ€๋Š” ๊ฐˆ

์ƒ‰์ด๋‹ค. ์œ ์ถฉ์—์„œ 1ํšŒ(์ˆ˜์ปท) ๋˜๋Š” 2ํšŒ(์•”์ปท)์˜ ์•ฝ์ถฉ์‹œ๊ธฐ๋ฅผ ๊ฑฐ

์ณ ์„ฑ์ถฉ์ด ๋˜๋ฉฐ ์•”์ปท์€ 300-450ฮผm, ์ˆ˜์ปท์€ 200-240ฮผm,

์œ ์ถฉ์€ 215ฮผm์˜ ํฌ๊ธฐ์ด๋‹ค. ์•”์ปท์€ ์ค‘์•™๋ถ€ ํ•˜๋‹จ์— ํ•ญ๋ฌธ๊ณผ

์ธ์ ‘ํ•˜์—ฌ ๊ด€์ƒ(tube-like)์˜ ๊ต์ ‘๋‚ญ(copulatory bursa)์ด

๋ฐฐ๋ฉด์œผ๋กœ ๊ฐœ๊ตฌํ•˜๊ณ  ์žˆ๊ณ , ์ฒซ ๋ฒˆ์งธ, ๋‘ ๋ฒˆ์งธ ๋‹ค๋ฆฌ์˜ ๋๊ด€์ ˆ์€

์ž๋ฃจ๊ฐ€ ๊ธด ํก๋ฐ˜(sucker)์„ ๊ฐ€์ง€๊ณ  ์žˆ์œผ๋ฉฐ ์„ธ ๋ฒˆ์งธ, ๋„ค ๋ฒˆ์งธ ๋‹ค

๋ฆฌ์˜ ๋ ๊ด€์ ˆ์€ ํ•œ ๊ฐœ์˜ ๊ธด ๊ฐ•๋ชจ๋ฅผ ๊ฐ€์ง€๊ณ  ์žˆ๋‹ค(Figure 1). ์ˆ˜

์ปท์€ ๋„ค ๋ฒˆ์งธ ๋‹ค๋ฆฌ ์‚ฌ์ด์— ๊ตํšŒ์ข… ๋ชจ์–‘์˜ ์ƒ์‹๊ธฐ๊ตฌ๋ฅผ ๊ฐ€์ง€๊ณ 

์žˆ์œผ๋ฉฐ ๋„ค ๋ฒˆ์งธ ๋‹ค๋ฆฌ์˜ ๋ ๊ด€์ ˆ์—๋„ ์ž๋ฃจ๊ฐ€ ๊ธด ํก๋ฐ˜์„ ๊ฐ€์ง€

๊ณ  ์žˆ๋‹ค(Figure 2). ๋ฐฐ๋ฉด์—๋Š” ์˜ด์ง„๋“œ๊ธฐ์˜ ํŠน์ง•์ ์ธ ๋Œ๊ธฐ(๋ณ€

ํ˜•๋œ ๊ฐ•๋ชจ)๊ฐ€ ์žˆ๋Š”๋ฐ ๋ฐฐ๋ฉด์ƒ๋ถ€์— 3์Œ์˜ ๋ฐฐ๋ฉด์›๋ฟ”๋Œ๊ธฐ

(dorsal cone), ๋ฐฐ๋ฉด ์ค‘์•™๋ถ€์œ„์— 100-170๊ฐœ์˜ ๋ฐฐ๋ฉด์ธ์ƒ๋Œ

๊ธฐ(squamous dorsal thorn) ๊ทธ๋ฆฌ๊ณ  7์Œ์˜ ๋ฐฐ๋ฉด๊ฐ€์‹œ๋Œ๊ธฐ

(dorsal spine)๊ฐ€ ๋ฐฐ๋ฉดํ•˜๋ถ€์— ์žˆ๋‹ค. ์•”์ปท ๊ฐœ์˜ด์ง„๋“œ๊ธฐ๋Š” ๋ฐฐ๋ฉด

์ธ์ƒ๋Œ๊ธฐ๊ฐ€ ์ด˜์ด˜ํ•˜๊ฒŒ ๋ถ„ํฌ๋˜์–ด ์žˆ์œผ๋‚˜ ์˜ด์ง„๋“œ๊ธฐ๋Š” ๋ฐฐ๋ฉด์—

๋ฐฐ๋ฉด์ธ์ƒ๋Œ๊ธฐ๊ฐ€ ๋ถ„ํฌ๋˜์–ด ์žˆ์ง€ ์•Š๋Š” ๋ฌด๋Œ๊ธฐ์ง€์—ญ(bare

area)์ด ์žˆ์œผ๋ฉฐ ๋ฐฐ๋ฉด์ธ์ƒ๋Œ๊ธฐ์˜ ์ˆ˜๋„ ๊ฐœ์˜ด์ง„๋“œ๊ธฐ ๋ณด๋‹ค ์ ์–ด

๊ตฌ๋ณ„ํ•  ์ˆ˜ ์žˆ๋‹ค(Figure 3) [2,9,10].

์•”์ปท์€ 4-6์ฃผ๊ฐ„ ์ƒ์กดํ•˜๋ฉฐ ํ‰๊ท  40-50๊ฐœ์˜ ์•Œ์„ ๋‚ณ๊ณ  ์•Œ

์€ 3-4์ผ ํ›„ ์œ ์ถฉ์œผ๋กœ ๋ถ„ํ™”๋˜๋ฉฐ(Figure 4) ์•ฝ์ถฉ์‹œ๊ธฐ๋ฅผ ๊ฑฐ์ณ

10-14์ผ ํ›„ ์„ฑ์ถฉ์ด ๋œ๋‹ค. ์•”์ปท์€ ํ”ผ๋ถ€ํ‘œ๋ฉด์—์„œ ์ˆ˜์ปท๊ณผ 1ํšŒ

๊ต๋ฏธํ•œ ํ›„ ๊ณง ๊ฐ์งˆ์ธต ๋‚ด์— ๊ตด(burrow)์„ ๋งŒ๋“ค๋ฉฐ ์ˆ˜์ปท์€ ๊ต

๋ฏธ ํ›„ 2์ผ ์ด๋‚ด์— ์ฃฝ์œผ๋ฏ€๋กœ ์•”์ˆ˜์˜ ๋น„๋Š” ์•ฝ 10:1๋กœ ์•”์ปท์ด

Dosal coneSquamous dorsal thorn

Bare area

Dorsal spineCopulatory ductAnus

Figure 1. Dorsal surface of female Sarcoptes scabiei showing na-mes of the characteristic morphological features.

Figure 2. Ventral surface of male Sarcoptes scabiei showing chu-rch bell-shaped male genitalia between 4th legs.

Page 3: Reemerging skin disease caused by arthropods I: scabies

์˜ํ•™๊ฐ•์ขŒReemerging skin disease caused by arthropods I: scabies

๋Œ€ํ•œ์˜์‚ฌํ˜‘ํšŒ์ง€ 513J Korean Med Assoc 2011 May; 54(5): 511-520

๋งŽ๋‹ค[11]. ์˜ด์ง„๋“œ๊ธฐ๋Š” ์ •์ƒ์ฒด์˜จ์˜ ํ”ผ๋ถ€ํ‘œ๋ฉด์—์„œ 1๋ถ„์— ์•ฝ

2.5 cm ์ด๋™ํ•˜๋ฉฐ ํ‰์ƒ์˜ ์‹ค๋‚ด์˜จ๋„์™€ ์Šต๋„์—์„œ 24-36์‹œ๊ฐ„

์ƒ์กดํ•  ์ˆ˜ ์žˆ๋‹ค[12].

์ž„์ƒ์ฆ์ƒ

์˜ด์€ ์˜ด์ง„๋“œ๊ธฐ์— ์˜ํ•œ ๊ตด์˜ ์ˆ˜, ๋”ฑ์ง€์„ฑ ๋ณ‘์†Œ ์œ ๋ฌด, ๊ตฌ์ง„์„ฑ ๋ณ‘

์†Œ ์œ ๋ฌด ๋“ฑ ์ž„์ƒ์ ์ธ ํŠน์ง•์ด๋‚˜ ์›์ธ์ด ๋˜๋Š” ์˜ด์ง„๋“œ๊ธฐ์˜ ์ข…์—

๋”ฐ๋ผ ์ผ๋ฐ˜์˜ด, ๋”ฑ์ง€์˜ด, ๊ฒฐ์ ˆ์˜ด, ์ž ํ–‰์˜ด, ๊ฐœ์˜ด ๋“ฑ์œผ๋กœ ๋ถ„๋ฅ˜๋œ๋‹ค.

1. ์ผ๋ฐ˜์˜ด

ํŠน์ง•์ ์ธ ์ž๊ฐ ์ฆ์ƒ์€ ๋ฐค์— ์‹ฌํ•ด์ง€๋Š” ์†Œ์–‘์ฆ์ด๋‹ค. ์†Œ์–‘์ฆ

์€ ํ™˜์ž๊ฐ€ ์ž ์ž๋ฆฌ์— ๋“ค์–ด ๋ชธ์ด ๋”ฐ๋œปํ•ด์ง€๋ฉด ๋Œ€๊ฐœ ์‹œ์ž‘๋˜๋ฉฐ ์˜ท

์„ ๋ฒ—์„ ๋•Œ๋ถ€ํ„ฐ ์‹œ์ž‘๋˜๊ธฐ๋„ ํ•œ๋‹ค. ์ด๋Ÿฌํ•œ ์†Œ์–‘์ฆ์€ ์˜ด์ง„๋“œ

๊ธฐ์— ๋Œ€ํ•œ ๊ณผ๋ฏผ๋ฐ˜์‘์œผ๋กœ ๋‚˜ํƒ€๋‚˜๊ณ  4-6์ฃผ๊ฐ„์˜ ์ž ๋ณต๊ธฐ๋ฅผ ๊ฑฐ

์ณ ๋‚˜ํƒ€๋‚˜๋ฉฐ ์ฒ˜์Œ๋ถ€ํ„ฐ ๋งŽ์€ ์ˆ˜์˜ ์ง„๋“œ๊ธฐ์— ๊ฐ์—ผ๋˜๋ฉด ์ž ๋ณต๊ธฐ

๊ฐ€ 1์ฃผ์ผ ์ด๋‚ด๋กœ ์งง์•„์งˆ ์ˆ˜๋„ ์žˆ๋‹ค[12].

์˜ด์ง„๋“œ๊ธฐ๋Š” ์ฃผ๋กœ ์•ผ๊ฐ„์— ๊ฐ์งˆ์ธต ๋‚ด์— ๊ตด์„ ๋งŒ๋“ค๊ณ  ์ด๋•Œ

์ง„๋“œ๊ธฐ์—์„œ ๋‚˜์˜ค๋Š” ์†Œํ™”์•ก๊ณผ ๊ฐ™์€ ๋ถ„๋น„๋ฌผ์ด ์•Œ๋ ˆ๋ฅด๊ธฐ๋ฐ˜์‘

์„ ์œ ๋ฐœํ•˜์—ฌ ๊ฐ€๋ ค์›€์ฆ์ด ๋‚˜ํƒ€๋‚˜๋Š” ๊ฒƒ์œผ๋กœ ์ถ”์ •๋œ๋‹ค. ์•”์ปท์€

์•ฝ 20๋ถ„ ์ •๋„๋ฉด ๊ฐ์งˆ์ธต ๋‚ด๋กœ ๋“ค์–ด๊ฐ€ ๋ชธ์„ ์ˆจ๊ธธ ์ˆ˜ ์žˆ์œผ๋ฉฐ ์ผ

๋‹จ ๊ต๋ฏธํ•œ ํ›„์—๋Š” ๊ตด์„ ๋งŒ๋“œ๋Š” ์ผ๊ณผ(1์ผ 2-3 mm) ์‚ฐ๋ž€์„

๋ฐ˜๋ณตํ•œ๋‹ค. ์ด์™€ ๊ฐ™์€ ์˜ด์ง„๋“œ๊ธฐ ๊ตด์€ ํšŒ์ƒ‰ ๋‚ด์ง€ ์•”๊ฐˆ์ƒ‰์˜ ๊ตด

๊ณก์ด ์žˆ๋Š” 5 mm ์ •๋„์˜ ์„ ์ƒ ๋ณ‘์†Œ๋กœ์„œ ์ˆ™๋‹ฌ๋œ ์‚ฌ๋žŒ์€ ๋งจ๋ˆˆ

์œผ๋กœ ์ฐพ์•„๋‚ผ ์ˆ˜ ์žˆ๋‹ค. ๊ตด์ด ์ข€ ์–ด๋‘์šด ์ƒ‰๊น”์„ ๋ ์–ด ์ฃผ์œ„ ํ”ผ๋ถ€

์™€ ๊ตฌ๋ณ„๋˜๋Š” ๊ฒƒ์€ ๋จผ์ง€๋‚˜ ๋•Œ ๊ฐ™์€ ๊ฒƒ์ด ๊ตด์˜ ์ƒ๋ถ€์— ๋ผ๊ธฐ ๋•Œ

๋ฌธ์ด๋‹ค. ๊ตด์ด ์‹œ์ž‘๋œ ๋ถ€๋ถ„์—๋Š” ์ž‘์€ ์ธ์„ค์ด ์žˆ์œผ๋ฉฐ ์˜ด์ง„๋“œ

๊ธฐ๊ฐ€ ์žˆ๋Š” ์ชฝ(blind end)์—๋Š” ๋ฏธ์„ธํ•œ ์œต๊ธฐ๊ฐ€ ๋ฐœ๊ฒฌ๋˜๋ฉฐ ๊ตด ํ•˜

๋ถ€์—์„œ๋Š” ์ž‘์€ ์ˆ˜ํฌ ๋˜๋Š” ๋†ํฌ๊ฐ€ ํ˜•์„ฑ๋˜๊ธฐ๋„ ํ•œ๋‹ค. ๊ตด์˜ ์•ฝ

90%๋Š” ์†๊ฐ€๋ฝ์‚ฌ์ด, ์†๋ชฉ์˜ ๊ตฝํž˜ ์ชฝ ๋ฐ ๋‚จ์ž์„ฑ๊ธฐ์—์„œ ๋ฐœ๊ฒฌ๋˜

๋ฉฐ[13] ๋“œ๋ฌผ๊ฒŒ ๋ณผ๊ธฐ, ๊ฒจ๋“œ๋ž‘์ด์—์„œ๋„ ๋ฐœ๊ฒฌ๋œ๋‹ค(Figures 5,6).

์œ ์•„๋‚˜ ์†Œ์•„ ๋˜๋Š” ๋…ธ์ธ์—์„œ๋Š” ๋ฐœ๋ฐ”๋‹ฅ, ์†๋ฐ”๋‹ฅ์—์„œ๋„ ํ”ํžˆ ๋ฐœ

๊ฒฌ๋œ๋‹ค(Figure 7).

๊ณผ๊ฑฐ 1970-1980๋…„๋Œ€์˜ ์˜ด์€ ๋Œ€๋ถ€๋ถ„ 10-30๋Œ€ ์—ฐ๋ น์—์„œ

๋ฐœ์ƒํ•˜์˜€์œผ๋‚˜[14-16] ์ตœ๊ทผ์—๋Š” 60๋Œ€ ์ดํ›„ ์—ฐ๋ น์ธต์— ๊ฐ€์žฅ

๋งŽ์ด ๋ฐœ์ƒํ•˜๊ณ  ์žˆ๋‹ค[4]. ๋…ธ์ธ ์—ฐ๋ น์ธต์— ๋ฐœ์ƒํ•  ๊ฒฝ์šฐ ๋น„์ „ํ˜•

์ ์ธ ์ฆ์ƒ์„ ๋ณด์ด๋Š” ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์œผ๋ฉฐ ๋…ธ์ธ์—์„œ ํ”ํžˆ ๋ฐœ์ƒ๋˜๋Š”

๋‹จ์ˆœ๊ฐ€๋ ค์›€์ฆ, ๊ฑด์„ฑ์Šต์ง„ ๋“ฑ์œผ๋กœ ์˜ค์ง„๋˜๋Š” ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์•„ ์ง„๋‹จ

์ด ์ง€์—ฐ๋˜๊ธฐ ์‰ฝ๋‹ค.

์ด์ฐจ ์„ธ๊ท ๊ฐ์—ผ์ด ์‹ฌํ•œ ๊ฒฝ์šฐ๋‚˜ ๋ฐœ๋ณ‘ ์ดˆ๊ธฐ์—๋Š” ๊ตด์„ ์ฐพ์•„๋‚ด

๊ธฐ๊ฐ€ ๋งค์šฐ ํž˜๋“œ๋‚˜ ์กฐ๋ช…์ด ์ž˜๋œ ๊ณณ์—์„œ ํ˜ธ๋ฐœ๋ถ€์œ„๋ฅผ ์ฃผ์˜ ๊นŠ์ด

์กฐ์‚ฌํ•˜๋ฉด ๋Œ€๋ถ€๋ถ„ ์ฐพ์•„ ๋‚ผ ์ˆ˜ ์žˆ๋‹ค. ์˜ด ํ™˜์ž์—์„œ ์ €์ž์— ๋”ฐ๋ผ

ํ‰๊ท  12๋งˆ๋ฆฌ, ๋˜๋Š” 10-15๋งˆ๋ฆฌ์˜ ์•”์ปท ์˜ด์ง„๋“œ๊ธฐ๊ฐ€ ๋ฐœ๊ฒฌ๋˜๋Š”

๊ฒƒ์œผ๋กœ ์•Œ๋ ค์ ธ ์žˆ์œผ๋‚˜[17] ์ผ๋ฐ˜์ ์œผ๋กœ ํ™˜์ž์˜ 80%์—์„œ 1-4

๊ฐœ์˜ ์˜ด์ง„๋“œ๊ธฐ ๊ตด์„ ๋ฐœ๊ฒฌํ•  ์ˆ˜ ์žˆ๋‹ค[14].

์‹ฌํ•œ ๊ฐ€๋ ค์›€์ฆ์„ ๋™๋ฐ˜ํ•˜๋Š” ํ™๋ฐ˜์„ฑ ๋ฐ˜ ๋ฐ ๊ตฌ์ง„๋“ค์€ ์ฃผ๋กœ

ํ™˜์ž์˜ ํ•˜๋ณต๋ถ€, ๋„“์ ๋‹ค๋ฆฌ ๋‚ด์ธก, ๊ฒจ๋“œ๋ž‘์ด ๋“ฑ์—์„œ ๋ณผ ์ˆ˜ ์žˆ์œผ

๋ฉฐ ์ด๋Ÿฌํ•œ ๋ณ‘์†Œ์˜ ๋ถ„ํฌ๋Š” ๊ตด์˜ ๋ถ„ํฌ์™€ ์ผ์น˜ํ•˜์ง€ ์•Š๋Š”๋‹ค. ์ด

์™€ ๊ฐ™์€ ํ˜„์ƒ์€ ์˜ด์˜ ๋Œ€๋ถ€๋ถ„์˜ ํ”ผ๋ถ€์ฆ์ƒ์€ ์˜ด์ง„๋“œ๊ธฐ์˜ ๋ฐฐ์„ค

๋ฌผ, ์†Œํ™”์•ก ๋“ฑ์— ๋Œ€ํ•œ ์ง€์—ฐ๊ณผ๋ฏผ๋ฐ˜์‘์œผ๋กœ ๋ฐœ์ƒํ•˜๊ธฐ ๋•Œ๋ฌธ์ด

๋‹ค. ๋”ฐ๋ผ์„œ ์žฌ๊ฐ์—ผ์‹œ์—๋Š” ์ ์€ ์ˆ˜์˜ ์˜ด์ง„๋“œ๊ธฐ์— ๊ฐ์—ผ๋˜์–ด๋„

24์‹œ๊ฐ„ ๋‚ด์— ์‹ฌํ•œ ๊ฐ€๋ ค์›€์ฆ์ด ๋ฐœ์ƒ๋˜๋ฉฐ ์ด๋•Œ์—๋Š” ๋Œ€๋ถ€๋ถ„์˜

Figure 3. Dorsal surface of Saroptes canis without bare area (A) and Sarcoptes scabiei with bare area (B).

Figure 4. A larva and eggs of Sarcoptes scabiei.

Bare area

A B

Page 4: Reemerging skin disease caused by arthropods I: scabies

514 ๋‹ค์‹œ ๋‚˜ํƒ€๋‚œ ์ ˆ์ง€๋™๋ฌผ์— ์˜ํ•œ ํ”ผ๋ถ€์งˆํ™˜โ… : ์˜ด J Korean Med Assoc 2011 May; 54(5): 511-520

Cho BK

๊ฒฝ์šฐ ์˜ด์ง„๋“œ๊ธฐ๋Š” ๊ณง ์†Œ๋ฉธ๋œ๋‹ค. ์˜ด์ง„๋“œ๊ธฐ๊ฐ€ ์†Œ๋ฉธ๋œ ํ›„์—๋„

์†Œ์–‘์ฆ์€ ์ˆ˜ ์ฃผ๊ฐ„ ๊ณ„์†๋  ์ˆ˜ ์žˆ๋‹ค[13].

2. ๋”ฑ์ง€์˜ด(Crusted scabies)

๋…ธ๋ฅด์›จ์ด ์˜์‚ฌ์— ์˜ํ•˜์—ฌ ์ฒ˜์Œ ๊ธฐ์ˆ ๋˜์–ด ๋…ธ๋ฅด์›จ์ด์˜ด

(Norwegian scabies)์ด๋ผ๊ณ ๋„ ํ•œ๋‹ค. ์†๊ณผ ์†๋ชฉ, ๋ฐœ, ํŒ”๊ฟˆ์น˜

ํ„์ชฝ ๋ถ€์œ„, ๋‘ํ”ผ, ๊ท€ ๋ฐ ์†ํ†ฑ ๋ฐ‘์—[18] ๊ณผ๋‹ค๊ฐํ™”์ฆ ํ˜„์ƒ์„ ๋ณด

์ด๋Š” ๊ฑด์„ ๋ชจ์–‘ ๋ณ‘๋ณ€์ด ํŠน์ง•์ ์ด๋ฉฐ, ์„ฑ๊ธฐ ๋ฐ ๋ณผ๊ธฐ์— ์‹ฌํ•œ ์ธ

์„ค ๋ฐ ๊ท ์—ด์„ ๋ณด์ด๊ธฐ๋„ ํ•œ๋‹ค(Figure 8). ๋…ธ์ธํ™˜์ž์—์„œ๋Š” ๋‘

ํ”ผ์— ์ง€๋ฃจํ”ผ๋ถ€์—ผ๊ณผ ์œ ์‚ฌํ•œ ์–‘์ƒ์œผ๋กœ ๋”ฑ์ง€์˜ด์ด ๋ฐœ์ƒํ•  ์ˆ˜ ์žˆ

์œผ๋ฏ€๋กœ ์ง„๋‹จ์‹œ ์œ ์˜ํ•˜์—ฌ์•ผ ํ•œ๋‹ค(Figure 9) [19].

๋”ฑ์ง€์˜ด ํ™˜์ž ์ค‘ 50%๋Š” ๊ฐ€๋ ค์›€์ฆ์ด

์ „ํ˜€ ์—†์œผ๋ฉฐ ๊ณผ๋‹ค๊ฐํ™”์ฆ์ด ์—†๋Š” ๋ถ€์œ„

๋ฅผ ์ž˜ ๊ด€์ฐฐํ•˜๋ฉด 25%์—์„œ ๊ตด์„ ๋ฐœ๊ฒฌํ• 

์ˆ˜ ์žˆ๋‹ค. 1 g์˜ ์ธ์„ค ์กฐ๊ฐ์—์„œ ์ˆ˜์ฒœ ๋งˆ

๋ฆฌ์˜ ์˜ด์ง„๋“œ๊ธฐ๊ฐ€ ๋ฐœ๊ฒฌ๋˜๋ฏ€๋กœ[20,21]

ํ•œ ํ™˜์ž์˜ ํ”ผ๋ถ€์— ๊ธฐ์ƒํ•˜๋Š” ์˜ด์ง„๋“œ๊ธฐ

์˜ ์ˆ˜๋Š” ์ˆ˜์‹ญ ๋งŒ ๋งˆ๋ฆฌ๊นŒ์ง€ ์ด๋ฅผ ์ˆ˜ ์žˆ์„

๊ฒƒ์œผ๋กœ ์ถ”์ •ํ•  ์ˆ˜ ์žˆ๋‹ค. ํ™˜์ž๋Š” ์ง์ ‘ ์ ‘

์ด‰ํ•˜๊ฑฐ๋‚˜ ์˜ค์—ผ๋œ ์˜๋ณต์ด๋‚˜ ํ˜ˆ์••๊ธฐ, ์ฒด

์˜จ๊ณ„ ๋“ฑ์„ ํ†ตํ•˜์—ฌ[20] ๋งŽ์€ ์ฃผ์œ„ ์‚ฌ๋žŒ

๋“ค์—๊ฒŒ ์˜ด์ง„๋“œ๊ธฐ๋ฅผ ์ „ํŒŒ ์‹œํ‚ฌ ์ˆ˜ ์žˆ๋‹ค. ๋˜ํ•œ ๋”ฑ์ง€์˜ด ํ™˜์ž๋กœ

๋ถ€ํ„ฐ ์ „์—ผ๋œ ํ™˜์ž์˜ ์˜ด์ง„๋“œ๊ธฐ ๊ตด์ด ์ฃผ๋กœ ํŒ”, ๋‹ค๋ฆฌ, ๋ชธํ†ต ๋“ฑ์—

์„œ ๋ฐœ๊ฒฌ๋œ๋‹ค๋Š” ์ ์œผ๋กœ ๋ณด์•„ ๊ณต๊ธฐ๋ฅผ ํ†ตํ•œ ๊ฐ„์ ‘์ „ํŒŒ ๋ฐฉ๋ฒ•๋„ ์ƒ

๊ฐํ•  ์ˆ˜ ์žˆ๋‹ค.

๋™๋ฐ˜๋˜๋Š” ์งˆํ™˜์€ ๋‹ค์šด์ฆํ›„๊ตฐ[22], ๋‚˜๋ณ‘, ์ •์‹ ์žฅ์• , ์‹ ๊ฒฝ

์žฅ์• , ๋ฉด์—ญ๊ฒฐํ•์ฆ, ์ž๊ฐ€๋ฉด์—ญ์งˆํ™˜[23], ๊ตญ์†Œ์Šคํ…Œ๋กœ์ด๋“œ์ œ ๊ณผ

๋‹ค์‚ฌ์šฉ[9] ๋“ฑ์„ ๋“ค ์ˆ˜ ์žˆ์œผ๋ฉฐ ์ด๋Ÿฐ ์งˆํ™˜๋“ค์—์„œ๋Š” ๋Œ€๊ฐœ ๊ฐ€๋ ค

์›€์ฆ์˜ ์œ ๋ฐœ์ด ์–ต์ œ๋œ๋‹ค. Kim ๋“ฑ[20]๊ณผ Lee ๋“ฑ[21]์€ ๋”ฑ์ง€

์˜ด ํ™˜์ž๊ฐ€ ๋‹ค๋ฅธ ์งˆํ™˜์œผ๋กœ ์ž…์› ์ค‘์— ๋ฐœ๊ฒฌ๋จ์œผ๋กœ ์ธํ•˜์—ฌ ์˜

์‚ฌ, ๊ฐ„ํ˜ธ์‚ฌ, ๋ณ‘์‹คํ™˜์ž์™€ ๋ณดํ˜ธ์ž ๋“ฑ 69๋ช…๊ณผ 22๋ช…์ด ๊ฐ๊ฐ ๊ฐ์—ผ

๋œ ๊ฒฝ์šฐ๋ฅผ ๋ณด๊ณ ํ•˜์˜€๋‹ค. ์ž„์ƒ์ ์œผ๋กœ๋Š” ๊ฑด์„ , ๋งŒ์„ฑ์Šต์ง„, ์‹ ๊ฒฝ

์„ฑํ”ผ๋ถ€์—ผ, ์†๋ฐœํ†ฑ์ง„๊ท ์ฆ ๋“ฑ๊ณผ ๊ฐ๋ณ„ํ•˜์—ฌ์•ผ ํ•œ๋‹ค.

3. ๊ฒฐ์ ˆ์˜ด(Nodular scabies)

๋ณดํ†ต ์˜ด์˜ ์ž„์ƒ์  ๋ณ€ํ˜•์œผ๋กœ ๋‚˜ํƒ€๋‚˜๋ฉฐ ์†Œ์–‘์ฆ์ด ์‹ฌํ•œ ํ™๋ฐ˜

์„ฑ ๋˜๋Š” ์ ๊ฐˆ์ƒ‰์˜ ๊ตฌ์ง„์ด๋‚˜ ๊ฒฐ์ ˆ์ด ์ƒ๊ธฐ๋Š” ๊ฒƒ์„ ๋งํ•œ๋‹ค. ํ†ต

์ƒ์ ์ธ ์˜ด์˜ ์ฆ์ƒ์ด ์†Œ์‹ค๋œ ํ›„์—๋„ ๊ฒฐ์ ˆ์ด ์ง€์†๋˜๋ฉฐ, ์ด๋Ÿฌํ•œ

๋ณ‘์†Œ๋Š” ์Œ๋‚ญ, ๋‚จ์ž์„ฑ๊ธฐ, ๊ฒจ๋“œ๋ž‘์ด์— ํ˜ธ๋ฐœํ•œ๋‹ค[24]. ์ดˆ๊ธฐ์—๋Š”

๊ฒฐ์ ˆ ํ‘œ๋ฉด์—์„œ ์˜ด์ง„๋“œ๊ธฐ ๊ตด์„ ๋ฐœ๊ฒฌํ•  ์ˆ˜ ์žˆ๋‹ค. ์˜ด์ด ์žฌ๋ฐœํ•˜

๋Š” ๊ฒฝ์šฐ์—๋Š” ์ฒ˜์Œ๋ถ€ํ„ฐ ๊ฒฐ์ ˆ์˜ด์ด ๋  ๊ฐ€๋Šฅ์„ฑ์ด ๋†’๋‹ค. 1์„ธ ๋ฏธ๋งŒ

์˜ ์˜์•„์—์„œ๋Š” ๋ชธํ†ต๊ณผ ์‚ฌ์ง€์— ์ž˜ ๋ฐœ์ƒ๋œ๋‹ค(Figure 10) [25].

4. ์ž ํ–‰์˜ด(Scabies incognito)

์˜ดํ™˜์ž๊ฐ€ ์ ์ ˆํ•œ ์น˜๋ฃŒ๋ฅผ ๋ฐ›์ง€ ์•Š๊ณ  ์žฅ๊ธฐ๊ฐ„ ๋ถ€์‹ ํ”ผ์งˆํ˜ธ๋ฅด

๋ชฌ์ œ๋ฅผ ๋ณต์šฉํ•˜๊ฑฐ๋‚˜ ๊ตญ์†Œ ๋„ํฌํ•˜๊ฒŒ ๋˜๋ฉด ๊ฐ€๋ ค์›€์ฆ์€ ์™„ํ™”๋˜

์ง€๋งŒ ์˜ด์ง„๋“œ๊ธฐ์˜ ์ˆ˜๋Š” ์ฆ๊ฐ€ํ•˜์—ฌ ์ฃผ์œ„ ์‚ฌ๋žŒ์ด ๋ชจ๋ฅด๋Š” ์‚ฌ์ด์—

Figure 5. Burrows on finger, finger web(A), wrist and palm (B).

Figure 6. Erythematous papules with burrow on the penis and scrotum.

A B

Page 5: Reemerging skin disease caused by arthropods I: scabies

์˜ํ•™๊ฐ•์ขŒReemerging skin disease caused by arthropods I: scabies

๋Œ€ํ•œ์˜์‚ฌํ˜‘ํšŒ์ง€ 515J Korean Med Assoc 2011 May; 54(5): 511-520

๊ณ„์† ์˜ด์ง„๋“œ๊ธฐ๋ฅผ ์ „ํŒŒํ•˜๋Š” ์ž ํ–‰์˜ด์œผ๋กœ ์ดํ–‰๋œ๋‹ค. ๊ตด์€ ์†,

์†๋ชฉ, ์Œ๋‚ญ ๋“ฑ์˜ ๋ถ€์œ„์— ์ˆ˜๋ฐฑ ๋‚ด์ง€ ์ˆ˜์ฒœ ๊ฐœ์— ๋‹ฌํ•˜๋‚˜ ๋”ฑ์ง€์˜ด

์—์„œ์™€ ๊ฐ™์€ ๊ณผ๋‹ค๊ฐํ™”์ฆ์€ ๋ณผ ์ˆ˜ ์—†๋‹ค[26]. ์ด์™€ ๊ฐ™์ด ๋งŽ์€

์ˆ˜์˜ ์˜ด์ง„๋“œ๊ธฐ๊ฐ€ ๊ธฐ์ƒํ•˜๊ณ  ์žˆ์œผ๋ฏ€๋กœ ํ”ผ๋ถ€ ํ‘œ๋ฉด์ด๋‚˜ ๋‚ด๋ณต์—

์„œ๋„ ์˜ด์ง„๋“œ๊ธฐ์˜ ์ฑ„์ง‘์ด ๊ฐ€๋Šฅํ•˜๋‹ค[27].

5. ๊ฐœ์˜ด(Canine scabies)

๊ฐœ์˜ด์ง„๋“œ๊ธฐ์— ์˜ํ•˜์—ฌ ๋ฐœ์ƒ๋œ๋‹ค. ๋™๋ฌผ์˜ด(animal scabies)

์˜ ์˜ด์ง„๋“œ๊ธฐ๋Š” ์ผ๋ฐ˜์ ์œผ๋กœ ์ˆ™์ฃผ ํŠน์ด์„ฑ์ด ์žˆ์–ด ์‚ฌ๋žŒ ํ”ผ๋ถ€์—

์„œ๋Š” ๊ตด์„ ๋งŒ๋“ค์ง€ ์•Š์œผ๋ฉฐ ๊ฐ์—ผ์›์ด ์†Œ์‹ค๋˜๋ฉด ์ž์—ฐ ์น˜์œ ๋  ์ˆ˜

์žˆ๋‹ค. ๊ฐœ์˜ด์€ ๋™๋ฌผ์˜ด ์ค‘ ์‚ฌ๋žŒ๊ณผ ๊ฐ€์žฅ ๋ฐ€์ ‘ํ•œ ๊ด€๊ณ„๊ฐ€ ์žˆ๋‹ค. ๊ฐœ

์˜ ์ฝ”, ๋ˆˆ ์ฃผ์œ„, ๊ท€, ๊ฒจ๋“œ๋ž‘์ด ๋“ฑ์—์„œ ์ดˆ๊ธฐ์— ํ™๋ฐ˜์„ฑ ๊ตฌ์ง„์ด

์‹œ์ž‘๋˜๋ฉฐ ๊ธ์Œ์œผ๋กœ ์ธํ•˜์—ฌ ํ”ผ๋ถ€๋Š” ๊นŒ์ง€๊ณ  ๋”ฑ์ง€๊ฐ€ ์ƒ๊ธฐ๋ฉฐ ์ 

์ฐจ ๋‘๊บผ์›Œ์ง€๊ณ  ํ‹ˆ์ƒˆ์™€ ์ฃผ๋ฆ„์ด ์ƒ๊ธฐ๊ฒŒ ๋˜์–ด ์ˆ˜๊ฐœ์›”์ด ์ง€๋‚˜๋ฉด

์‚ฌ๋žŒ์˜ ๋”ฑ์ง€์˜ด๊ณผ ๊ฐ™์€ ์ฆ์ƒ์„ ๋ณด์ธ๋‹ค(Figure 11) [28]. ์‚ฌ๋žŒ

์— ์ „์—ผ๋  ๊ฒฝ์šฐ ์ž ๋ณต๊ธฐ๊ฐ€ ์งง์•„์ ธ 3-4์ผ ๋˜๋Š” ๋น ๋ฅธ ๊ฒฝ์šฐ ์ˆ˜

Figure 7. Burrows and eczematous changes on the sole of a 80-year-old female patient. Figure 9. Crusted scabies showing seborrheic dermatitis-like yel-

lowish hyperkeratotic patches on the scalp in a 86 -year- old man admitted in an eldercare hospital (courtesy of Professor Moo Kyu Suh, Dongguk University).

Figure 10. Nodular scabies in a 9-month-old boy (courtesy of Pro-fessor Moon Bum Kim, Pusan National University).

Figure 8. Crusted scabies showing hyperkeratotic patches on the glans penis and pubic area in a 71-year-old man.

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516 ๋‹ค์‹œ ๋‚˜ํƒ€๋‚œ ์ ˆ์ง€๋™๋ฌผ์— ์˜ํ•œ ํ”ผ๋ถ€์งˆํ™˜โ… : ์˜ด J Korean Med Assoc 2011 May; 54(5): 511-520

Cho BK

์‹œ๊ฐ„ ๋‚ด์— ๊ฐ€๋ ค์›€์ฆ์ด ๋‚˜ํƒ€๋‚  ์ˆ˜ ์žˆ๋‹ค. ํ”ผ๋ถ€ ๋ณ‘์†Œ๋Š” ๊ฐœ์™€ ์ ‘

์ด‰๋ถ€์œ„์— ๋‚˜ํƒ€๋‚˜๋ฏ€๋กœ ์•„๋ž˜ํŒ”, ํ‰๋ถ€, ๋ณต๋ถ€, ๋„“์ ๋‹ค๋ฆฌ ๋‚ด์ธก๋ถ€

๊ฐ€ ํ˜ธ๋ฐœ ๋ถ€์œ„์ด๋‹ค[29]. ๊ฐœ์˜ด์ง„๋“œ๊ธฐ๋Š” ์‚ฌ๋žŒ ํ”ผ๋ถ€์— ๊ตด์„ ๋งŒ๋“ค

์ง€ ์•Š์œผ๋ฏ€๋กœ ๋ณ‘์†Œ์—์„œ ๊ฐœ์˜ด์ง„๋“œ๊ธฐ๋ฅผ ๋ฐœ๊ฒฌํ•˜๊ธฐ ์–ด๋ ค์šฐ๋‚˜ ๋งค์šฐ

๋“œ๋ฌผ๊ฒŒ ๋ฐœ๊ฒฌ๋˜๊ธฐ๋„ ํ•œ๋‹ค[30]. ์˜ด์ง„๋“œ๊ธฐ๊ฐ€ ๋ฐœ๊ฒฌ๋œ ๊ฒฝ์šฐ, ์•”์ปท

๊ฐœ์˜ด์ง„๋“œ๊ธฐ์˜ ํ˜•ํƒœํ•™์ ์ธ ํŠน์ง•์ธ ๋ฐฐ๋ฉด ์ธ์ƒ๋Œ๊ธฐ๊ฐ€ ๋ฌด๋Œ๊ธฐ์ง€

์—ญ์ด ์—†์ด ์ด˜์ด˜ํ•˜๊ฒŒ ๋ถ„ํฌ๋˜์–ด ์žˆ๋Š”์ง€๋ฅผ ํ™•์ธํ•˜์—ฌ์•ผ ํ•œ๋‹ค[2].

์˜ด์˜ ์ง„๋‹จ

ํŠน์ง•์ ์ธ ์•ผ๊ฐ„์˜ ๊ฐ€๋ ค์›€์ฆ๊ณผ ์˜ด์ง„๋“œ๊ธฐ ๊ตด์˜ ๋ฐœ๊ฒฌ, ๊ฐ€์กฑ๋ ฅ

๋“ฑ์œผ๋กœ ์ง„๋‹จํ•  ์ˆ˜ ์žˆ์œผ๋ฉฐ ํ˜„๋ฏธ๊ฒฝํ•˜์—์„œ ์˜ด์ง„๋“œ๊ธฐ์˜ ์ถฉ์ฒด๋‚˜

์•Œ ๋˜๋Š” ๋ฐฐ์„ค๋ฌผ(scybala)์„ ํ™•์ธํ•˜๋ฉด ํ™•์ง„ํ•  ์ˆ˜ ์žˆ๋‹ค. ์†๊ฐ€

๋ฝ์‚ฌ์ด ๋ฐ ์Œ๋‚ญ๊ณผ ๋‚จ์ž์„ฑ๊ธฐ์— ์‹ฌํ•œ ๊ฐ€๋ ค์›€์ฆ์ด ์žˆ์„ ๊ฒฝ์šฐ ์ง„

๋‹จ์— ๋„์›€์ด ๋œ๋‹ค. ์œ ์ถฉ ๋˜๋Š” ์•ฝ์ถฉ์œผ๋กœ ์ธํ•˜์—ฌ ์•„์ฃผ ์ž‘์€ ๊ตด,

๊ตฌ์ง„ ๋˜๋Š” ์ˆ˜ํฌ๊ฐ€ ํ˜•์„ฑ๋˜๋ฏ€๋กœ ํ™•๋Œ€๊ฒฝ์„ ์ด์šฉํ•˜์—ฌ ์ฃผ์˜ ๊นŠ๊ฒŒ

๊ด€์ฐฐ ํ•  ํ•„์š”๊ฐ€ ์žˆ๋‹ค. ์œ ์•„๋‚˜ ์†Œ์•„ ๋˜๋Š” ๋…ธ์ธํ™˜์ž์—์„œ๋Š” ํŠน

ํžˆ ์†๋ฐ”๋‹ฅ, ๋ฐœ๋ฐ”๋‹ฅ์—์„œ ์˜ด์ง„๋“œ๊ธฐ ๊ตด์„ ์ฐพ์•„๋ณด๋Š” ๊ฒƒ์ด ์ค‘์š”ํ•˜

๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ์ž ํ–‰์˜ด์ด๋‚˜ ๋”ฑ์ง€์˜ด์—์„œ๋Š” ๊ฐ€๋ ค์›€์ฆ์ด ๊ฒฝํ•˜๊ฑฐ๋‚˜

์—†์œผ๋ฉฐ ๊ฐœ์˜ด์—์„œ๋Š” ๊ตด์ด ๋ฐœ๊ฒฌ๋˜์ง€ ์•Š๋Š”๋‹ค.

์˜ด์ง„๋“œ๊ธฐ๋ฅผ ๊ฒ€์‚ฌํ•˜๋Š” ๋ฐฉ๋ฒ•์€ Muller ๋“ฑ[31]์ด ์ œ์‹œํ•œ ๊ด‘

์œ (mineral oil)๋ฒ•์ด ๋งค์šฐ ํŽธ๋ฆฌํ•˜๋‹ค. ๊ฒ€์‚ฌ๋ฐฉ๋ฒ•์€ ๊ด‘์œ  ํ•œ ๋ฐฉ

์šธ์„ ๊ตด ์œ„์— ๋–จ์–ด๋œจ๋ฆฌ๊ณ  ์™ธ๊ณผ์šฉ ์นผ๋กœ 6-7ํšŒ ๊ตด์„ ๊ฐ€๋กœ ์งˆ๋Ÿฌ

๋ฌธ์ง€๋ฅธ ํ›„ ๊ฐ์งˆ์„ธํฌ ์กฐ๊ฐ๋“ค์ด ํฌํ•จ๋œ

๊ด‘์œ ๋ฅผ ๊ธ์–ด๋ชจ์•„ ์œ ๋ฆฌ์Šฌ๋ผ์ด๋“œ ์œ„์—

๋†“๊ณ  ๋ฎ๊ฐœ์œ ๋ฆฌ๋ฅผ ๋ฎ์€ ๋‹ค์Œ ๊ด‘ํ•™ํ˜„๋ฏธ

๊ฒฝ์œผ๋กœ ๊ด€์ฐฐํ•œ๋‹ค(Figure 12). ์นผ๋กœ ํ”ผ

๋ถ€๋ฅผ ๋ฌธ์ง€๋ฅผ ๋•Œ์—๋Š” ์ ํ˜ˆ๊ตฌ๊ฐ€ ์•ฝ๊ฐ„ ์„ž

์ผ ์ •๋„์˜ ์„ธ๊ธฐ๋กœ ํ•˜๋Š” ๊ฒƒ์ด ์ข‹๋‹ค. ์ด

๊ฒ€์‚ฌ ๋ฐฉ๋ฒ•์˜ ์žฅ์ ์€ ๊ด‘์œ ์˜ ์ ์„ฑ์— ์˜

ํ•˜์—ฌ ์ถฉ์ฒด๋Š” ๋ฌผ๋ก  ๊ตด์˜ ๋ชจ๋“  ๋‚ด์šฉ๋ฌผ์„

์†์‹ค ์—†์ด ๋ชจ์„ ์ˆ˜ ์žˆ์œผ๋ฉฐ ์‚ด์•„ ์›€์ง์ด

๋Š” ์ถฉ์ฒด๋ฅผ ๊ฒ€์ถœํ•  ์ˆ˜ ์žˆ๊ณ  ์ง„๋‹จ์— ๋„์›€

์ด ๋˜๋Š” 20-30ฮผm ํฌ๊ธฐ์˜ ๊ฐˆ์ƒ‰ ํƒ€์›

ํ˜• ๋ฐฐ์„ค๋ฌผ๋„ ํ•จ๊ป˜ ๊ฒ€์ถœ ํ•  ์ˆ˜ ์žˆ๋‹ค๋Š”๋ฐ

์žˆ๋‹ค(Figure 13) [32].

๊ด‘์œ ๊ฐ€ ์—†์„ ๊ฒฝ์šฐ ๊ธ€๋ฆฌ์„ธ๋ฆฐ์ด๋‚˜ ํ˜„๋ฏธ๊ฒฝ ๊ณ ๋ฐฐ์œจ ๊ด€์ฐฐ์‹œ ์‚ฌ

์šฉ๋˜๋Š” cedar oil์„ ์ด์šฉํ•  ์ˆ˜๋„ ์žˆ๋‹ค. ์ตœ๊ทผ์—๋Š” ์ƒ‰์†Œ์„ฑ ํ”ผ

๋ถ€์งˆํ™˜์˜ ๊ฐ๋ณ„์ง„๋‹จ์— ํ”ํžˆ ์‚ฌ์šฉ๋˜๋Š” dermoscopy๊ฐ€ ์˜ด์˜

์ง„๋‹จ์— ์‚ฌ์šฉ๋˜๊ณ  ์žˆ์œผ๋ฉฐ ์˜์•„๋‚˜ ์†Œ์•„ํ™˜์ž์—์„œ์ฒ˜๋Ÿผ ๊ฒ€์‚ฌ ์‹œ

ํ˜‘์กฐ๊ฐ€ ์–ด๋ ค์šด ๊ฒฝ์šฐ, ์˜ด์ง„๋“œ๊ธฐ๋ฅผ ๋ฐœ๊ฒฌํ•˜๋Š”๋ฐ ๋„์›€์„ ์ฃผ๊ณ  ์žˆ

๋‹ค[25]. Dermoscopy๋Š” ์ƒ์ฒด ๋‚ด ํ‘œ๋ฉดํ˜„๋ฏธ๊ฒฝ(surface mi-

croscopy)์œผ๋กœ โ€˜epiluminescence microscopyโ€™๋ผ๊ณ ๋„ ํ•œ

๋‹ค[33]. 10-20๋ฐฐ๋กœ ํ™•๋Œ€ํ•˜์—ฌ ํ”ผ๋ถ€๋ณ‘์†Œ๋ฅผ ๊ด€์ฐฐํ•˜๋ฉฐ ์‚ฌ์ง„์„

์ฐ์„ ์ˆ˜ ์žˆ์œผ๋ฉฐ, ๊ฐˆ์ƒ‰์œผ๋กœ ๋ณด์ด๋Š” ์‚ผ๊ฐํ˜• ๋ชจ์–‘์˜ ์˜ด์ง„๋“œ๊ธฐ

์•ž๋ถ€๋ถ„๊ณผ(hang glider sign) ํ•จ๊ป˜ ๊ณต๊ธฐ๋ฐฉ์šธ๊ณผ ๋ถ„๋น„๋ฌผ๋กœ ์ฐจ

์žˆ๋Š” ๊ตด๋กœ ์ด๋ฃจ์–ด์ง„ โ€˜์ œํŠธ๊ธฐ์™€ ๋น„ํ–‰๊ตฌ๋ฆ„(jet with conden-

sation trail)โ€™์„ ๊ด€์ฐฐ ํ•  ์ˆ˜ ์žˆ๋‹ค(Figure 14) [25].

๋ณ‘๋ฆฌ์กฐ์งํ•™์ ์œผ๋กœ ๊ฐ์งˆ์ธต ๋‚ด์—์„œ ์ถฉ์ฒด๋ฅผ ๊ด€์ฐฐ ํ•  ์ˆ˜ ์žˆ์œผ

๋ฉฐ ์ด๋•Œ ์ถฉ์ฒด์˜ ์•…์ฒด๋ถ€๋Š” ๋ณดํ†ต ๊ณผ๋ฆฝ์ธต ์ƒ๋ถ€์— ์ ‘ํ•˜๊ณ  ์žˆ๋‹ค.

๊ณผ๋‹ค๊ฐํ™”์ฆ๊ณผ ๊ตญ์†Œ์  ํ•ด๋ฉดํ™” ๋ฐ ์„ธํฌ๊ฐ„ ๋ถ€์ข… ๋‚ด์—์„œ ํ˜ธ์ค‘๊ตฌ

์™€ ํ˜ธ์‚ฐ๊ตฌ์˜ ์นจ์œค๋„ ์ฐพ์•„ ๋ณผ ์ˆ˜ ์žˆ๋‹ค. ์ง„ํ”ผ์˜ ํ˜ˆ๊ด€์ฃผ์œ„์—์„œ

๋ฆผํ”„๊ตฌ, ์กฐ์ง๊ตฌ, ํ˜ธ์‚ฐ๊ตฌ ๋ฐ ํ˜ธ์ค‘๊ตฌ์˜ ์นจ์œค์„ ๋ณผ ์ˆ˜ ์žˆ๋‹ค[9].

์ตœ๊ทผ ์˜ด์ง„๋“œ๊ธฐ์— ๊ฐ์—ผ๋œ ์‹คํ—˜๋™๋ฌผ์˜ ํ˜ˆ์ฒญ ๋‚ด ํ•ญ์ฒด์™€ ๋ฐ˜์‘ํ•˜

๋Š” ์˜ด์ง„๋“œ๊ธฐ ํ•ญ์›์— ๊ด€ํ•œ ๋งŽ์€ ์—ฐ๊ตฌ๊ฐ€ ์ด๋ฃจ์–ด์ง€๊ณ  ์žˆ์œผ๋ฉฐ ๊ทธ

์ค‘ ์ผ๋ถ€๋Š” ์ง‘๋จผ์ง€์ง„๋“œ๊ธฐ์ธ Dermatophagoides pterony-

ssinus์™€ ์ƒ๋™์„ฑ์„ ๋ณด์ด๊ณ  ์žˆ๋‹ค. ์ด์™€ ๊ฐ™์€ ์˜ด์ง„๋“œ๊ธฐ ํ•ญ์›

๋ฐ ์œ ์ „์ž์˜ ์—ฐ๊ตฌ๋Š” ์˜ด์˜ ์ง„๋‹จ๋ฟ ์•„๋‹ˆ๋ผ ๋ฉด์—ญ์น˜๋ฃŒ(immu-

notherapy)๋ฅผ ๋ชฉํ‘œ๋กœ ์ง„ํ–‰๋˜๊ณ  ์žˆ๋‹ค[3,6]. ๋”ฑ์ง€์˜ด์—์„œ๋Š” ๊ณผ

Figure 11. Clinical and electronmicroscopic findings of canine scabies of a dog.

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์˜ํ•™๊ฐ•์ขŒReemerging skin disease caused by arthropods I: scabies

๋Œ€ํ•œ์˜์‚ฌํ˜‘ํšŒ์ง€ 517J Korean Med Assoc 2011 May; 54(5): 511-520

๋‹ค๊ฐํ™”์ฆ์œผ๋กœ ๋‘๊บผ์›Œ์ง„ ๊ฐ์งˆ์ธต ๋‚ด์— ๋ฒŒ์ง‘๊ณผ ๊ฐ™์ด ์ธต์ธต์œผ๋กœ

ํ˜•์„ฑ๋œ ํ„ฐ๋„ ๋‚ด์—์„œ ๋ชจ๋“  ๋ฐœ์œก๋‹จ๊ณ„์˜ ์˜ด์ง„๋“œ๊ธฐ๋ฅผ ๋ณผ ์ˆ˜ ์žˆ๋‹ค

(Figure 15).

๋…ธ์ธ์š”์–‘์‹œ์„ค์—์„œ๋Š” ๊ฐ„๋ณ‘์ธ, ์ง์›, ๋ฐฉ๋ฌธ๊ฐ ๋“ฑ์„ ํ†ตํ•˜์—ฌ ์ „

ํŒŒ ๋  ์ˆ˜ ์žˆ์œผ๋ฏ€๋กœ ํ™˜์ž ์ ‘์ด‰ ์ „๊ณผ ํ›„์— ์†์”ป๊ธฐ ๋“ฑ ์œ„์ƒ์ˆ˜์น™์„

์ž˜ ์ง€์ผœ์•ผ ํ•œ๋‹ค. ๋…ธ์ธํ™˜์ž์—์„œ๋Š” ์†๊ฐ€๋ฝ์ด๋‚˜ ์†๊ฐ€๋ฝ์‚ฌ์ด์—

๊ตด์„ ๋ณด์ด๋Š” ์ „ํ˜•์ ์ธ ๋ณ‘๋ณ€์ด ๋“œ๋ฌผ๊ณ  ๊ตฌ์ง„์„ฑํ”ผ๋ถ€์—ผ(papular

dermatitis)์ด๋‚˜ ์Šต์ง„์„ฑ ๋ณ‘๋ณ€๊ณผ ๊ฐ™์ด ๋น„์ „ํ˜•์ ์ธ ์ž„์ƒ์ฆ์ƒ์„

๋ณด์ด๋Š” ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์œผ๋ฏ€๋กœ ์ดˆ๊ธฐ ์ง„๋‹จ์— ์‹คํŒจํ•˜๊ธฐ ์‰ฝ๋‹ค[34].

์˜ด์˜ ์น˜๋ฃŒ

์˜ด์ด ํ™•์ง„๋˜๋ฉด ์˜ด์ง„๋“œ๊ธฐ๋ฅผ ๋ฐ•๋ฉธํ•  ์ˆ˜ ์žˆ๋Š” ์ ์ ˆํ•œ ๊ตญ์†Œ๋„

ํฌ์ œ๋ฅผ ์„ ํƒํ•˜๊ณ  ๊ฐ€์กฑ์€ ๋ฌผ๋ก  ์‹ ์ฒด์ ‘์ด‰

์ด ์žˆ์—ˆ๋˜ ๋ชจ๋“  ์‚ฌ๋žŒ์ด ํ•จ๊ป˜ ์น˜๋ฃŒ๋ฅผ ํ•˜

๋Š” ๊ฒƒ์ด ์ค‘์š”ํ•˜๋‹ค. ํ•ญ์˜ด์ง„๋“œ๊ธฐ์ œ ๊ตญ์†Œ

๋„ํฌ์™€ ํ•จ๊ป˜ ์˜ด์ง„๋“œ๊ธฐ์˜ ๋ฐฐ์„ค๋ฌผ ๋“ฑ์—

์˜ํ•œ ์•Œ๋ ˆ๋ฅด๊ธฐ๋ฐ˜์‘์œผ๋กœ ์œ ๋ฐœ๋œ ํ”ผ๋ถ€์—ผ

์„ ์น˜๋ฃŒํ•˜๊ธฐ ์œ„ํ•ด ํ•ญํžˆ์Šคํƒ€๋ฏผ์ œ ๊ฒฝ๊ตฌํˆฌ

์—ฌ์™€ ํ•จ๊ป˜ ๊ฐ€๋ฒผ์šด ์Šคํ…Œ๋กœ์ด๋“œ์ œ ๊ตญ์†Œ๋„

ํฌ๊ฐ€ ํ•„์š”ํ•˜๋‹ค. ํ”ผ๋ถ€๋ฐœ์ง„์ด ์‹ฌํ•˜์—ฌ ๊ตญ

์†Œ๋„ํฌ์ œ ๋งŒ์œผ๋กœ ํ˜ธ์ „๋˜์ง€ ์•Š์„ ๊ฒฝ์šฐ

1-2์ฃผ๊ฐ„์˜ ์Šคํ…Œ๋กœ์ด๋“œ์ œ๋ฅผ ๊ฒฝ๊ตฌํˆฌ์—ฌ

ํ•  ์ˆ˜ ์žˆ์œผ๋ฉฐ 2์ฐจ ์„ธ๊ท ๊ฐ์—ผ์ด ์žˆ์„ ๊ฒฝ์šฐ

์ ์ ˆํ•œ ํ•ญ์ƒ์ œ๋ฅผ ๋ณ‘ํ–‰ํˆฌ์—ฌ ํ•˜์—ฌ์•ผ ํ•œ๋‹ค.

ํ”ํžˆ ์‚ฌ์šฉ๋˜๋Š” ํ•ญ์˜ด์ง„๋“œ๊ธฐ์ œ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™๋‹ค.

1. Lindane

์•ฝ์„ ๋ฐ”๋ฅด๊ณ  6์‹œ๊ฐ„ ํ›„์— ์”ป์–ด ๋‚ด์–ด์•ผํ•˜๋ฉฐ 1์ฃผ์ผ ํ›„ ํ•œ๋ฒˆ

๋” ์‚ฌ์šฉํ•œ๋‹ค. ์‹ฌํ•œ ์•„ํ† ํ”ผ ํ”ผ๋ถ€์—ผ์ด๋‚˜ ๊ฑด์„  ๋“ฑ๊ณผ ๊ฐ™์ด ๊ด‘๋ฒ”

์œ„ํ•œ ์—ผ์ฆ์„ฑ ํ”ผ๋ถ€์งˆํ™˜์ด ์žˆ๊ฑฐ๋‚˜, 2์ฐจ ์„ธ๊ท ๊ฐ์—ผ์ด ์žˆ๋Š” ๊ฒฝ์šฐ

์—๋Š” ์‚ฌ์šฉํ•˜์ง€ ์•Š๋Š” ๊ฒƒ์ด ์ข‹๋‹ค. ๊ณผ๋Ÿ‰ ์‚ฌ์šฉํ•  ๊ฒฝ์šฐ ์ค‘์ถ”์‹ ๊ฒฝ

๊ณ„์— ์ค‘๋… ์ฆ์ƒ์ด ์žˆ์„ ์ˆ˜ ์žˆ์œผ๋ฏ€๋กœ, ์œ ์•„๋‚˜ ์†Œ์•„ ๋ฐ ์ž„์‚ฐ๋ถ€

๋Š” ์‚ฌ์šฉํ•˜์ง€ ์•Š๋Š” ๊ฒƒ์ด ์ข‹๋‹ค. ํŠนํžˆ ๋ฐœ์ž‘(seizure) ์ฆ์ƒ์ด ์žˆ

๋Š” ์†Œ์•„๋‚˜ ์„ฑ์ธ์—์„œ๋Š” ๋”์šฑ ์ฃผ์˜๋ฅผ ์š”ํ•œ๋‹ค. ๋‹ค๋ฅธ ์˜ด์น˜๋ฃŒ์ œ

๋กœ ์น˜๋ฃŒ์— ์‹คํŒจํ•œ ๊ฒฝ์šฐ์—๋Š” ์œ ์•„์—์„œ๋„ ์กฐ์‹ฌ์Šค๋Ÿฝ๊ฒŒ ์‚ฌ์šฉ ํ• 

์ˆ˜ ์žˆ๋‹ค[35]. ์šฐ๋ฆฌ๋‚˜๋ผ์—์„œ ๊ฐ€์žฅ ํ”ํžˆ ์‚ฌ์šฉ๋˜๊ณ  ์žˆ์œผ๋ฉฐ 1%

๋กœ์…˜, ๊ฒ”, ํฌ๋ฆผ, ์ƒดํ”„์ œ๋กœ 6๊ฐœ ์ œ์•ฝํšŒ์‚ฌ์—์„œ ์ƒ์‚ฐ๋˜๊ณ  ์žˆ๋‹ค.

Figure 12. Procedures of scraping for scabies using mineral oil.

Figure 13. Scybala and a vellus hair (A), and scybala and an egg (B) of Sarcoptes scabiei.

A B

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518 ๋‹ค์‹œ ๋‚˜ํƒ€๋‚œ ์ ˆ์ง€๋™๋ฌผ์— ์˜ํ•œ ํ”ผ๋ถ€์งˆํ™˜โ… : ์˜ด J Korean Med Assoc 2011 May; 54(5): 511-520

Cho BK

์œ ๋Ÿฝ์—ฐํ•ฉ์—์„œ๋Š” 2001๋…„๋ถ€ํ„ฐ ๋‹ค๋ฅธ ์•ฝ์ œ์— ์ €ํ•ญ์„ ๋ณด์ด๋Š” ๊ฒฝ

์šฐ์—๋งŒ ์‚ฌ์šฉ์ด ํ—ˆ์šฉ๋˜๊ณ  ์žˆ๋‹ค[3].

2. Crotamiton

๋ƒ„์ƒˆ๊ฐ€ ์—†๊ณ  ํ”ผ๋ถ€์— ์ž๊ทน์„ ์ฃผ์ง€ ์•Š์œผ๋ฉฐ ํ•ญ์†Œ์–‘ ํšจ๊ณผ๋„

์žˆ๋‹ค. ๊ฒฐ์ ˆ์˜ด์ด๋‚˜ ์†Œ์•„์— ์‚ฌ์šฉํ•˜๋Š” ๊ฒƒ์ด ์ข‹์œผ๋ฉฐ ๊ฒฐ์ ˆ์ด ์žˆ

๋Š” ๋ถ€์œ„์—๋Š” ์žฅ๊ธฐ๊ฐ„ ๋„ํฌํ•œ๋‹ค. ์น˜๋ฃŒํšจ๊ณผ๋Š” lindane๋ณด๋‹ค ๋–จ

์–ด์ง€๋ฏ€๋กœ lindane์˜ ์‚ฌ์šฉ์ด ์–ด๋ ค์šด ์†Œ์•„๋‚˜ ์ž„์‚ฐ๋ถ€์— ์ฃผ๋กœ

์‚ฌ์šฉ๋œ๋‹ค[12,36]. 10% ์—ฐ๊ณ , ํฌ๋ฆผ, ๊ฒ” ์ œ์ œ๋กœ 20์—ฌ ๊ฐœ ์ œ์•ฝ

ํšŒ์‚ฌ์—์„œ ์ƒ์‚ฐํ•˜๊ณ  ์žˆ๋‹ค. ํ•œ ์—ฐ๊ตฌ์—์„œ 4์ฃผ๊ฐ„ ์†Œ์•„ ์˜ดํ™˜์ž ์น˜

๋ฃŒ ํ›„ ์™„์น˜์œจ์€ 60%์˜€์œผ๋ฉฐ permethrin์˜ 89%์— ๋น„ํ•˜์—ฌ ์ €

์กฐํ•˜์˜€๋‹ค[37].

3. Benzyl benzoate ์šฉ์•ก

20-25% ์ˆ˜์šฉ์•ก์„ ์ž๊ธฐ ์ „ ๋„ํฌํ•˜๊ณ  ์•„์นจ์— ๋ชฉ์š•ํ•œ๋‹ค. ์—ฐ

์† 2์ผ๊ฐ„ ๋„ํฌํ•˜๊ณ  1์ฃผ์ผ ํ›„ ๋ฐ˜๋ณตํ•œ๋‹ค. ์ ๋ง‰์ด๋‚˜ ์Œ๋‚ญ ๋ฐ ์„ฑ

๊ธฐ์—๋Š” ์‹ฌํ•œ ์ž๊ทน ๋ฐ˜์‘์ด ์žˆ์„ ์ˆ˜ ์žˆ๋‹ค. ์œ ์•„์—๋Š” ์‚ฌ์šฉํ•˜์ง€

์•Š๋Š” ๊ฒƒ์ด ์ข‹์œผ๋ฉฐ ์†Œ์•„๋‚˜ ์ž„์‚ฐ๋ถ€์—์„œ๋Š” 10-15%๋กœ ํฌ์„ํ•œ

์ˆ˜์šฉ์•ก์„ ์ฃผ์˜ํ•˜์—ฌ ์‚ฌ์šฉํ•  ์ˆ˜ ์žˆ๋‹ค. 1970-1980๋…„๋Œ€์— ์‚ฌ์šฉ

๋˜์—ˆ์œผ๋‚˜ ํ˜„์žฌ ์šฐ๋ฆฌ๋‚˜๋ผ์—์„œ๋Š” ์ƒ์‚ฐ๋˜๊ณ  ์žˆ์ง€ ์•Š๋‹ค. ํ”„๋ž‘์Šค

์—์„œ๋Š” ์˜ด์˜ ์ผ์ฐจ ์น˜๋ฃŒ์ œ๋กœ ๋„๋ฆฌ ์‚ฌ์šฉ๋˜๊ณ  ์žˆ๋‹ค[12].

4. 5% permethrin ์—ฐ๊ณ 

์ „์‹  ํก์ˆ˜๊ฐ€ ์ ๊ณ  ์‹ ์†ํžˆ ๋ฐฐ์„ค๋˜๋ฏ€๋กœ ๋ถ€์ž‘์šฉ์ด ์ ๊ณ  ํšจ๊ณผ

๋„ ์šฐ์ˆ˜ํ•˜๋‹ค. ์ž๊ธฐ ์ „ ์ „์‹ ์— 1ํšŒ ๋„ํฌํ•˜๊ณ  8-12์‹œ๊ฐ„ ํ›„ ์”ป

์–ด ๋‚ธ๋‹ค. ์ƒํ›„ 2๊ฐœ์›” ์ดํ›„์˜ ์œ ์•„์—์„œ๋„ ์‚ฌ์šฉํ•  ์ˆ˜ ์žˆ๋‹ค. ๋ฏธ

๊ตญ์—์„œ๋Š” ์ผ์ฐจ ์น˜๋ฃŒ์ œ๋กœ ์‚ฌ์šฉ๋˜๊ณ  ์žˆ์œผ๋‚˜ ์šฐ๋ฆฌ๋‚˜๋ผ์—์„œ๋Š”

์•„์ง ์ƒ์‚ฐ๋˜๊ณ  ์žˆ์ง€ ์•Š์œผ๋ฉฐ ํ•œ๊ตญํฌ๊ท€์˜์•ฝํ’ˆ์„ผํ„ฐ๋ฅผ ํ†ตํ•ด์„œ

๊ตฌํ•  ์ˆ˜ ์žˆ๋‹ค. Lindane์ด๋‚˜ crotamiton๋ณด๋‹ค ๊ณ ๊ฐ€์ด๋‹ค.

5. Ivermectin

ํšŒ์„ ์‚ฌ์ƒ์ถฉ์ฆ(onchocerciasis)์˜ ๊ฒฝ๊ตฌ์ฒด๋ฃŒ์ œ๋กœ ์‚ฌ์šฉํ•˜

๋˜ ์•ฝ๋ฌผ์ด๋ฉฐ ์‹ฌํ•œ ์˜ดํ™˜์ž์—์„œ 0.2 mg/kg์„ 2์ฃผ ๊ฐ„๊ฒฉ์œผ๋กœ

2ํšŒ ํˆฌ์—ฌํ•˜๊ฑฐ๋‚˜ 0.4 mg/kg์„ 1ํšŒ ํˆฌ์—ฌํ•œ๋‹ค. ๋”ฑ์ง€์˜ด์ด๋‚˜ ๋…ธ

์ธ์š”์–‘์‹œ์„ค ๋“ฑ์—์„œ ๋‹ค์ˆ˜ ๋ฐœ์ƒํ–ˆ์„ ๊ฒฝ์šฐ ํšจ๊ณผ์ ์ธ ์น˜๋ฃŒ์ œ๋กœ

์ถ”์ฒœ๋˜๊ณ  ์žˆ๋‹ค[12]. ์šฐ๋ฆฌ๋‚˜๋ผ์—์„œ๋Š” ๊ฐœ๋‚˜ ๊ณ ์–‘์ด์˜ ์‹ฌ์žฅ์‚ฌ

์ƒ์ถฉ ์น˜๋ฃŒ๋‚˜ ๋ผ์ง€์˜ด ๋“ฑ์— ์‚ฌ์šฉ๋˜๊ณ  ์žˆ์œผ๋‚˜ ์‚ฌ๋žŒ์šฉ ์ œ์ œ๋Š” ์ƒ

์‚ฐ๋˜๊ณ  ์žˆ์ง€ ์•Š๋‹ค.

์˜ดํ™˜์ž ์น˜๋ฃŒ์— ์žˆ์–ด ์œ ์˜ํ•  ์‚ฌํ•ญ์„ ์š”์•ฝํ•˜๋ฉด ๋‹ค์Œ๊ณผ ๊ฐ™๋‹ค

[7,13].

1) ์ ์ ˆํ•œ ์น˜๋ฃŒ์ œ์˜ ์„ ํƒ

2) ์ผ์ •ํ•œ ์–‘๋งŒ ์ฒ˜๋ฐฉํ•˜์—ฌ ๊ณผ๋„ํ•œ ์น˜๋ฃŒ๋กœ ์ธํ•œ ๋ถ€์ž‘์šฉ ์˜ˆ๋ฐฉ

3) ๋ชฉ์—์„œ ๋ฐœ๋๊นŒ์ง€ ์ „์‹ ์— ๊ณจ๊ณ ๋ฃจ ๋„ํฌ(์œ ์•„๋‚˜ ๋…ธ์ธ์—์„œ๋Š”

๋จธ๋ฆฌ๋‚˜ ์–ผ๊ตด๋„ ํฌํ•จํ•˜๋ฉฐ ํŠนํžˆ ๋…ธ์ธ ํ™˜์ž์—์„œ๋Š” ๋งˆ๋น„๋กœ ์ธ

Figure 14. Dermoscopic findings of scabies showing hang glider sign with โ€œcondensation trailโ€ (courtesy of Dr. Ju Hyuk Park, Hallym University).

Figure 15. Histopathologic findings of scabies showing a burrow containing a female itch mite and an egg (H&E, x200).

Page 9: Reemerging skin disease caused by arthropods I: scabies

์˜ํ•™๊ฐ•์ขŒReemerging skin disease caused by arthropods I: scabies

๋Œ€ํ•œ์˜์‚ฌํ˜‘ํšŒ์ง€ 519J Korean Med Assoc 2011 May; 54(5): 511-520

ํ•˜์—ฌ ์ˆ˜์ถ•๋˜๊ฑฐ๋‚˜ ๊ตด๊ณก์ง„ ๋ถ€์œ„๋„ ๋น ํŠธ๋ฆฌ์ง€ ์•Š์•„์•ผ ํ•œ๋‹ค)

4) ํ•œ์ง‘์•ˆ ๊ฐ€์กฑ๋“ค์„ ์ฆ์ƒ์œ ๋ฌด์— ๊ด€๊ณ„์—†์ด ๋™์‹œ์— ์น˜๋ฃŒ

5) ํ™˜์ž๊ฐ€ ์ ‘์ด‰ํ•œ ์‚ฌ๋žŒ๋“ค์„ ์ถ”์ ํ•˜์—ฌ ์น˜๋ฃŒ

6) ์•ฝ๋ฌผ์‚ฌ์šฉ์— ๋Œ€ํ•˜์—ฌ ๊ตฌ๋‘ ๋˜๋Š” ์ธ์‡„๋ฌผ๋กœ ์ƒ์„ธํžˆ ์„ค๋ช…

7) 1์ฃผ ๋ฐ 4์ฃผ ํ›„์— ํšจ๊ณผ ํŒ์ •

8) ๋‚ด๋ณต๊ณผ ์นจ๊ตฌ๋Š” ํ•ญ์˜ด์ง„๋“œ๊ธฐ์ œ์ œ๋ฅผ ๋ฐ”๋ฅด๋Š” ๋‚ ์€ ๊ฐ™์€ ๊ฒƒ

์„ ์‚ฌ์šฉํ•œ ํ›„ ๋œจ๊ฑฐ์šด ๋ฌผ(50-60โ„ƒ)๋กœ 10-20๋ถ„๊ฐ„ ์„ธํƒํ•˜๊ณ 

์„ธํƒ ํ›„ 3์ผ๊ฐ„ ์‚ฌ์šฉํ•˜์ง€ ์•Š๋Š”๋‹ค. ์„ธํƒ์ด ์–ด๋ ค์šด ๊ฒƒ์€ 2์ผ๊ฐ„

ํ–‡๋ณ•์— ๋„๊ฑฐ๋‚˜ ๋‹ค๋ฆฌ๋ฏธ๋กœ ๋‹ค๋ฆฐ ํ›„ ์‚ฌ์šฉ ํ•  ์ˆ˜ ์žˆ๋‹ค.

์ดˆ๊ธฐ์— ์ ์ ˆํ•œ ์น˜๋ฃŒ๋ฅผ ๋ฐ›์œผ๋ฉด ์ˆ˜ ์ฃผ ๋‚ด์— ํ˜ธ์ „๋œ๋‹ค. ๊ฒฐ์ ˆ

์˜ด์ธ ๊ฒฝ์šฐ ์Šคํ…Œ๋กœ์ด์ œ์ œ๋ฅผ ๊ตญ์†Œ๋„ํฌํ•˜๊ฑฐ๋‚˜ ๋ณ‘๋ณ€๋‚ด ์ฃผ์‚ฌํ•˜

์—ฌ ์น˜๋ฃŒํ•˜๋ฉฐ pimecrolimus ํฌ๋ฆผ ๋„ํฌ๋„ ํšจ๊ณผ๋ฅผ ๋ณด์ธ๋‹ค[38].

80%์˜ ํ™˜์ž์—์„œ 3๊ฐœ์›” ์ •๋„ ํ›„ ์น˜์œ ๋˜๋‚˜ ์ˆ˜๊ฐœ์›”๊นŒ์ง€ ์ง€์†

๋˜๋Š” ๊ฒฝ์šฐ๋„ ์žˆ๋‹ค.

๊ฒฐ ๋ก 

์˜ด์€ ์ „์—ผ์„ฑ์ด ๋งค์šฐ ๊ฐ•ํ•˜๊ณ  ์‹ฌํ•œ ๊ฐ€๋ ค์›€์ฆ์„ ๋™๋ฐ˜ํ•˜๋Š” ํ”ผ

๋ถ€์งˆํ™˜์ด๋ฉฐ ์˜ด์ง„๋“œ๊ธฐ๊ฐ€ ํ”ผ๋ถ€ ๊ฐ์งˆ์ธต์— ๊ธฐ์ƒํ•˜์—ฌ ๋ฐœ์ƒ๋œ๋‹ค.

์šฐ๋ฆฌ๋‚˜๋ผ์—์„œ๋Š” 1970๋…„ ์ดˆ๋ถ€ํ„ฐ 1980๋…„๋Œ€ ์ดˆ๊นŒ์ง€ ์ „๊ตญ์ ์ธ

๋Œ€๋ฐœ์ƒ์ด ์žˆ์€ ํ›„ ์ ์ฐจ ๊ฐ์†Œํ•˜์—ฌ ์™ธ๋ž˜ํ™˜์ž์˜ 0.1% ๋‚ด์™ธ๋กœ

๊นŒ์ง€ ๊ฐ์†Œํ•˜์˜€์œผ๋‚˜ 5-6๋…„ ์ „๋ถ€ํ„ฐ ๋‹ค์‹œ ์ฆ๊ฐ€ํ•˜๋Š” ์ถ”์„ธ๋ฅผ ๋ณด

์ด๊ณ  ์žˆ๋‹ค. ์˜ด์ด ์ „ ์„ธ๊ณ„์ ์œผ๋กœ ์ฃผ๊ธฐ์ ์ธ ๋Œ€๋ฐœ์ƒ์„ ๋ณด์ด๋Š”

๊ฒƒ์€ ์ „์Ÿ๊ณผ ๋นˆ๊ณค ๋“ฑ์œผ๋กœ ์ธํ•œ ์—ด์•…ํ•œ ์ƒํ™œํ™˜๊ฒฝ์— ์˜ํ•œ ๊ฒƒ์œผ

๋กœ ์ถ”์ •๋˜๊ณ  ์žˆ์œผ๋‚˜ ์ตœ๊ทผ ์šฐ๋ฆฌ๋‚˜๋ผ๋ฅผ ๋น„๋กฏํ•˜์—ฌ ์ „ ์„ธ๊ณ„์ ์ธ

๋ฐœ์ƒ์ฆ๊ฐ€๋Š” ๋…ธ์ธ์š”์–‘์‹œ์„ค ์ฆ๊ฐ€๋กœ ์ธํ•œ ๋…ธ์ธํ™˜์ž์˜ ์ฆ๊ฐ€, ์˜

๋ฃŒ ์ข…์‚ฌ์ž๋“ค์˜ ๋ฌด๊ด€์‹ฌ๊ณผ ๊ฒฝํ—˜๋ถ€์กฑ ๊ทธ๋ฆฌ๊ณ  ์˜ด์ง„๋“œ๊ธฐ์˜ ํ•ญ์˜ด

์ง„๋“œ๊ธฐ์ œ์— ๋Œ€ํ•œ ๋‚ด์„ฑ์ฆ๊ฐ€ ๋“ฑ์— ์˜ํ•œ ๊ฒƒ์œผ๋กœ ๋ณด์ธ๋‹ค. ์šฐ๋ฆฌ

๋‚˜๋ผ์—์„œ ๊ณผ๊ฑฐ 30์—ฌ ๋…„ ์ „๊ณผ ๊ฐ™์€ ์˜ด์˜ ๋Œ€๋ฐœ์ƒ์„ ์˜ˆ๋ฐฉํ•˜๊ธฐ

์œ„ํ•ด์„œ๋Š” ๋ฌด์—‡๋ณด๋‹ค ์˜์‚ฌ๋“ค์˜ ์˜ด์˜ ์ฆ์ƒ, ์ง„๋‹จ, ์น˜๋ฃŒ ๋“ฑ์— ๋Œ€

ํ•œ ์˜ฌ๋ฐ”๋ฅธ ์ดํ•ด์™€ ๊ด€์‹ฌ์ด ์ ˆ์‹คํžˆ ์š”๊ตฌ๋˜๊ณ  ์žˆ๋‹ค.

ํ•ต์‹ฌ์šฉ์–ด: ์˜ด; ์˜ด์ง„๋“œ๊ธฐ; ๋…ธ์ธ์š”์–‘์‹œ์„ค; Lindane; Crotamiton

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Cho BK

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๋ณธ ๋…ผ๋ฌธ์€ ์ตœ๊ทผ ์šฐ๋ฆฌ๋‚˜๋ผ์—์„œ ์ฆ๊ฐ€ํ•˜๊ณ  ์žˆ๋Š” ์˜ด์— ๋Œ€ํ•˜์—ฌ ์˜ด ์ง„๋“œ๊ธฐ์˜ ํ˜•ํƒœ์™€ ์ƒํ™œ์‚ฌ, ์ž„์ƒ์ฆ์ƒ๊ณผ ์ข…๋ฅ˜, ์ง„๋‹จ๋ฒ• ๋ฐ ์น˜๋ฃŒ์—

๋Œ€ํ•˜์—ฌ ๊ธฐ์ˆ ํ•˜๊ณ  ์žˆ๋‹ค. ์˜ด์€ ์‚ฌํšŒ์ ์ธ ํ™˜๊ฒฝ์˜ ๋ณ€ํ™”์— ๋”ฐ๋ผ ๋ฐœ์ƒ๋นˆ๋„, ๋ฐœ๋ณ‘์–‘์ƒ๊ณผ ํŠน์„ฑ์ด ๋‹ค๋ฅผ ์ˆ˜ ์žˆ๋‹ค. ์ตœ๊ทผ์— ๋ฐœ์ƒํ•˜๋Š” ์˜ด

์˜ ํŠน์ง•์€ ๋…ธ์ธ์—์„œ ๋งŽ๊ณ , ๋…ธ์ธ ์ง‘๋‹จ์ˆ˜์šฉ์‹œ์„ค์—์„œ ๋ฐœ์ƒํ•˜๋ฉด ์ „์—ผ์„ฑ์ด ๊ฐ•ํ•˜์—ฌ ์‹œ์„ค ๋‚ด์˜ ๋‹ค๋ฅธ ์‚ฌ๋žŒ๊ณผ ๋ณ‘์›์— ๊ทผ๋ฌดํ•˜๋Š” ์ง์›

์—๊ฒŒ ์ „์—ผ์„ ์ผ์œผ์ผœ ์‚ฌํšŒ์ ์ธ ๋ฌธ์ œ๊ฐ€ ๋˜๊ณ  ์žˆ๋‹ค. ์ด๋Ÿฐ ์‹œ๊ธฐ์— ํŠนํžˆ ์ง‘๋‹จ์‹œ์„ค์—์„œ ๊ทผ๋ฌดํ•˜๊ณ  ์žˆ๋Š” ์˜์‚ฌ๋Š” ๋ฌผ๋ก , ์ผ๋ฐ˜ ์˜์‚ฌ๋„

์˜ด์˜ ์ฆ์ƒ์„ ํŒŒ์•…ํ•  ์ˆ˜ ์žˆ๋„๋ก ๋งŽ์€ ์‚ฌ์ง„์ž๋ฃŒ๋ฅผ ์ œ๊ณตํ•˜์—ฌ ์ดํ•ด๋ฅผ ๋†’๊ฒŒ ํ•˜์˜€์œผ๋ฉฐ, ์˜ด์„ ์ง„๋‹จํ•˜๋Š” ๋ฐฉ๋ฒ•์— ๋Œ€ํ•˜์—ฌ๋„ ํ’๋ถ€ํ•œ ์‚ฌ

์ง„์ž๋ฃŒ์™€ ํ•จ๊ป˜ ๊ธฐ์ˆ ํ•˜์—ฌ ์ดํ•ด๋„๋ฅผ ๋†’์˜€๊ณ , ์น˜๋ฃŒ๋ฒ•๊ณผ ํ•จ๊ป˜ ์น˜๋ฃŒ ์‹œ ์ฃผ์˜ํ•˜์—ฌ์•ผํ•  ์‚ฌํ•ญ์„ ์ž์„ธํ•˜๊ฒŒ ๊ธฐ์ˆ ํ•˜์˜€๋‹ค. ์ด๋ฅผ ํ†ตํ•ด ์˜ด

์„ ์กฐ๊ธฐ์— ์ง„๋‹จํ•˜์—ฌ ์ ์ ˆํ•˜๊ฒŒ ์น˜๋ฃŒํ•จ์œผ๋กœ์จ ์˜ด์˜ ์ „ํŒŒ๋ฅผ ์˜ˆ๋ฐฉํ•˜๋Š”๋ฐ ๋งŽ์€ ๋„์›€์„ ์ค„ ๊ฒƒ์œผ๋กœ ๊ธฐ๋Œ€๋œ๋‹ค.

[์ •๋ฆฌ:ํŽธ์ง‘์œ„์›ํšŒ]

Peer Reviewersโ€™ Commentary