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NeurOn: Modeling Ontology for Neurosurgery
K. S. Raghavan & C. SajanaIndian Statistical Institute Bangalore
Information & Healthcare• Health care is a knowledge intensive activity;
Available knowledge is a fluid mix of:– Scholarly documents– New experiences– Contextual information– Expert insights
collectively providing a framework for decision-making
Information & Healthcare
• Patient records as an important source of valuable information – Much of this valuable information may not even
appear in published sources or become a part of standard texts until years later
• Quality of health care vis-à-vis access to patient records with defined similarities to the problem on hand
Decision-making is… something which concerns all of us, both as makers of the choice and as sufferers of the consequences.
-D. Lindley
K. S. Raghavan, Indian Statistical Institute, Bangalore, India
BackgroundThe work reported here is set in a large hospital (and
is in progress)– Present system & its limitations
• WINISIS database with hyperlinks to related files (Such as X-rays, CT Scans, Pathology reports, etc)– Data on a large number of parameters– The range of relations between concepts in a complex
domain such as health care – Search technologies in thesauri – based IR systems
The Present Study• Hypotheses– Ontologies can help build more effective information
support systems in healthcare.– Ontologies can support the need of the healthcare and
delivery process to transmit, re-use and share patient data
• Why Ontology?– Ontologies are effective in representing domain
knowledge – Possible to include ‘IF – THEN’ rules to support
inferencing
Ontology?• Gruber’s Definition: “Explicit Specification of a
Conceptualization” • Studer’s extension: “ a formal, explicit
specification of a shared conceptualization” • For practical purposes and applications a
domain ontology could be perceived as:– The complete set of domain concepts and their
interrelationships
Ontology?• A semantic network of concepts grouped into
classes and subclasses and linked by means of a well defined set of relations. Ontologies also have a set of rules that support inferencing
The Project• About 1500 patient records of the
Neurosurgery unit of a large hospital – The neurological disorder • disease name (Final Diagnosis)
– specific treatment – symptoms – associated illnesses – Patient Data; name, ID number, doctor’s name,
disease index number, gender, age, age range, consciousness level, visual acuity details , etc
The central theme of every patient record ran more or less like this:
A Patient Has Neurological
Disorder
that is
Diagnosed
and
Treated Using Method of
Treatment Leading to
Result
Domain ConceptsPatient Records contained four broad types of
data:
• These could be categorized under the 3 top level categories of Ranganathan, viz., Personality [P], Matter Property [MP] and Energy [E]
Patient-Related data
Medicine-Related
Concepts
Healthcare Personnel
Related data
Institution-Related data
Queries• In building the ontology it was important to
have some idea of the nature of queries that the system should respond to:– Identify• Patients above 40 years of age and suffering from
Astrocytoma• Patients with brain diseases having symptoms of
headache and visual impairment• Records of patients who were administered drug XXX
and had post – surgery complication of vision loss
Queries
• While a clear picture will emerge only after the system is implemented; – A small query library was built to serve as the
basis for defining classes and sub-classes
The Ontology
• No one perfect way of building an ontology– Definition of classes, properties, etc.• decisions regarding how detailed the classes and / or
relations should be is largely based on the purpose and ease of maintenance– ’female patients’ could be seen as a subclass of ‘patients’; it
could also be handled as: Patient HAS GENDER and by fdefining acceptable values for gender
The Ontology• The decision-support system proposed here is
conceived to have at least two major components when completed:– The ontology as part of the search interface; and– A database of patient records linked to related
records in other databases, e.g. of images (scans, X-rays, etc)
Populating the Ontology• Phase 1 – Medicine-related concepts - neurological
disorders including associated symptoms and characteristics and their treatment –
– patient data. Other sub-domain concepts will be added later
• Complex nature of relations
Populating the Ontology• Structuring the terms into a hierarchy – Inconsistencies in terminology used by hospital’s
health-care personnel
• SNOMED CT was used to standardize the terminology– Corresponding MeSH Terms & terms used by
hospital personnel built in as relations: [SNOMED CT for Domain Concept] <has physician’s term> [Term
used in the patient record]
Populating the Ontology
• Properties– Object– Data type
• A general idea of the class hierarchy and properties (see Figure)
Future work• To be implemented in the hospital – Only a limited number of patient records used– Tested with a few sample queries
• To include concepts related to healthcare institutions and personnel
• To link relevant manuals, reference sources, text books and papers with a view to widen the knowledge base available to the users of the decision support system
Future work• To build rules for inferencing that allow– reasonable and intelligent guess of the probable
cause or condition of a patient based on values of certain clinical parameters
– decision regarding the possible course of action– defining parameters that could generate an alert
message
Future work• The complexity of medical terminology; – Non-availability of exact equivalents for some of
the terms used (in patient records) in the standard medical terminologies (like MeSH and SNOMED CT)
– Ethical issues
• Can we define principles for decisions regarding ‘classes’ ‘subclasses’ ‘properties’ and ‘relation types’ for ontology?