Upload
duongtu
View
220
Download
0
Embed Size (px)
Citation preview
Florida Chapter of the Health Physics SocietySpring 2016 Technical Meeting01 April 2016
RADIOACTIVE PATIENT RELEASEGlenn M. Sturchio, PhD, CHPMayo Clinic in Jacksonville[Jeffrey J. Brunette, CHP; Mayo Clinic in Rochester]
SAFETY
Today’s Journey
©2011 MFME
SAFETY
NCRP Program Area Committee 2: Operational Radiation Safety
SAFETY©2011 MFMER |
slide-4
SAFETY
Background Radiation
NCRP Report 160
SAFETY
Adult Effective Doses for Various CT Procedures
Radiology: Vol 248: Number 1 – July 2008
SAFETY
Adult Effective Doses for Various Interventional Radiology Procedures
Radiology: Vol 248: Number 1 – July 2008
SAFETY
Effective Doses for Adults from Various Nuclear Medicine Examinations
Radiology: Vol 248: Number 1 – July 2008
SAFETY
Effective Doses for Adults from Various Nuclear Medicine Examinations
Radiology: Vol 248: Number 1 – July 2008
= 20 mCi
SAFETY
Effective Doses for Adults from Various Nuclear Medicine Examinations
Radiology: Vol 248: Number 1 – July 2008
= 20 mCi
= 30 mCi
SAFETY
Effective Doses for Adults from Various Nuclear Medicine Examinations
Radiology: Vol 248: Number 1 – July 2008
= 20 mCi
= 30 mCi
= 30 mCi
SAFETY
SAFETY
10 CFR 35.75, Release of Individuals …
Outpatient or Inpatient
Patient-Specific
Dose Calculation
Measured Dose Rate
Administered Activity
NUREG-1556, Vol 9, Rev 2
SAFETY
Activities and Dose Rates for Patient Release
RadionuclideActivity At or Below
Which Patient may BeReleased (mCi)
Dose Rate @ 1mAt or Below Which
Patient may BeReleased (mrem/h)
I-131 33 7Tc-99m 760 58
F-18 330 185Y-90 ** **
NUREG-1556, Vol 9, Rev 2
SAFETY
Effective Doses for Adults from Various Nuclear Medicine Examinations
Radiology: Vol 248: Number 1 – July 2008
= 20 mCi
= 30 mCi
= 30 mCi
SAFETY
Mayo Clinic in RochesterWhere Radioiodine Patients Come From?
52% within 100 miles.
15% within 100 - 250 miles21% within 250 – 500 miles 9% could drive, > 500 miles, and
3% international
SAFETY
So How Do We Get These People Home?
SAFETY
Wheel of Fortune?
SAFETY
Eligibility
SAFETY
Retained 131I
Med Phys 42(4), April 2015
SAFETY
SAFETY
SAFETY
SAFETY
10 CFR 35.75, Release of Individuals …
Outpatient or Inpatient
Patient-Specific
Dose Calculation
Measured Dose Rate
Administered Activity
NUREG-1556, Vol 9, Rev 2
SAFETY
Our Approach• Start with the NRC calculation model
• Add a number of improvements
• Revise equations to “compartmentalize” calculation
SAFETY
NRC Calculation Model • From NUREG 1556, vol. 9, Appendix U:
• where, Fi, Ti are uptake and effective half-lives, Γ is the gamma constant, Q0 is administered activity, d is the distance, and Tp is physical half-life.
𝐃𝐃 ∞
=𝟑𝟑𝟑𝟑.𝟔𝟔 𝚪𝚪 𝐐𝐐𝟎𝟎
𝐝𝐝𝟐𝟐�𝐄𝐄𝟏𝟏𝐓𝐓𝐏𝐏(𝟎𝟎.𝟖𝟖) 𝟏𝟏 − 𝐞𝐞−𝟎𝟎.𝟔𝟔𝟔𝟔𝟑𝟑 𝐓𝐓𝐍𝐍𝐍𝐍 /𝐓𝐓𝐏𝐏
+ 𝐄𝐄𝟐𝟐𝐞𝐞−𝟎𝟎.𝟔𝟔𝟔𝟔𝟑𝟑(𝐓𝐓𝐍𝐍𝐍𝐍)/𝐓𝐓𝐏𝐏�𝐅𝐅𝟏𝟏𝐓𝐓𝟏𝟏 𝟏𝟏 − 𝐞𝐞−𝟎𝟎.𝟔𝟔𝟔𝟔𝟑𝟑(𝐭𝐭−𝐓𝐓𝐍𝐍𝐍𝐍)/𝐓𝐓𝟏𝟏
SAFETY
Revisions to NRC Calculations• Account for self-shielding
In post-thyroidectomy thyroid carcinoma, self-shielding: Γ = 1.7 R-cm2/mCi-hr1
• Non-voiding time NRC uses 8 hours. NCRP uses rapid uptake and 3.5 hour voiding in
dosimetry calculations. Others suggest using 1 hour. We chose 3.5 hours and eliminated the “0.8” factor
that the NRC uses.
1 K. Nelson measurements and Carey JE, et. al., Release of Patients Containing Therapeutic Doses of Iodine-131 from Hospitals. J Nucl Med Technol 23:144-149; 1995.
SAFETY
Revisions to NRC Calculations• Occupancy
E = 1 while in transit E = 0.25 at all other times
• Distance d = 1 meter most of the time (instructions), Car distances measured, d = 1 meter in car
(instructions to sit as far apart as possible)2, Air travel distances, d = 0.6 meter.
2 J. Brunette measurements in a variety of vehicle types. Excludes motorcycles and mini-vehicles (Smart Car / 2-seater vehicles)..
SAFETY
Revisions to NRC Calculations• Limit on radiation dose:
5 mSv (0.5 rem) to adult care-giver accompanying patient on travel home, and
1 mSv (0.1 rem) to others encountered during travel home.
• Equations split into components for: Dose during “pre-travel phase”, Dose during “travel phase”, and Dose during “post-travel phase”.
.
SAFETY
Revised Equations• Example (assumes immediate travel home by car):
• where,
.
𝐃𝐃 ∞ = 𝐃𝐃 𝐫𝐫𝐫𝐫𝐝𝐝𝐫𝐫𝐫𝐫𝐫𝐫 𝐫𝐫𝐫𝐫 𝐜𝐜𝐜𝐜𝐫𝐫 + 𝐃𝐃(𝐩𝐩𝐩𝐩𝐩𝐩𝐭𝐭 𝐭𝐭𝐫𝐫𝐜𝐜𝐭𝐭𝐞𝐞𝐭𝐭 / 𝐜𝐜𝐭𝐭 𝐡𝐡𝐩𝐩𝐡𝐡𝐞𝐞)
𝐃𝐃 𝐫𝐫𝐫𝐫𝐝𝐝𝐫𝐫𝐫𝐫𝐫𝐫 𝐫𝐫𝐫𝐫 𝐜𝐜𝐜𝐜𝐫𝐫
=𝟑𝟑𝟑𝟑.𝟔𝟔 𝚪𝚪 𝐐𝐐𝟎𝟎
𝐝𝐝𝟐𝟐�𝐄𝐄𝐓𝐓𝐓𝐓𝐏𝐏 𝟏𝟏 − 𝐞𝐞−𝟎𝟎.𝟔𝟔𝟔𝟔𝟑𝟑 𝐓𝐓𝐍𝐍𝐍𝐍 /𝐓𝐓𝐏𝐏
+ 𝐄𝐄𝐓𝐓𝐞𝐞−𝟎𝟎.𝟔𝟔𝟔𝟔𝟑𝟑(𝐓𝐓𝐍𝐍𝐍𝐍)/𝐓𝐓𝐏𝐏�𝐅𝐅𝟏𝟏𝐓𝐓𝟏𝟏 𝟏𝟏 − 𝐞𝐞−𝟎𝟎.𝟔𝟔𝟔𝟔𝟑𝟑(𝐭𝐭−𝐓𝐓𝐍𝐍𝐍𝐍)/𝐓𝐓𝟏𝟏
𝐃𝐃 𝐩𝐩𝐩𝐩𝐩𝐩𝐭𝐭 𝐭𝐭𝐫𝐫𝐜𝐜𝐭𝐭𝐞𝐞𝐭𝐭/𝐜𝐜𝐭𝐭 𝐡𝐡𝐩𝐩𝐡𝐡𝐞𝐞
=𝟑𝟑𝟑𝟑.𝟔𝟔 𝚪𝚪 𝐐𝐐𝟎𝟎
𝐝𝐝𝟐𝟐�𝐄𝐄𝟐𝟐𝐞𝐞−𝟎𝟎.𝟔𝟔𝟔𝟔𝟑𝟑(𝐓𝐓𝐍𝐍𝐍𝐍)/𝐓𝐓𝐏𝐏�𝐅𝐅𝟏𝟏𝐓𝐓𝟏𝟏 𝐞𝐞−𝟎𝟎.𝟔𝟔𝟔𝟔𝟑𝟑(𝐭𝐭−𝐓𝐓𝐍𝐍𝐍𝐍)/𝐓𝐓𝟏𝟏
SAFETY
You possessed of sturdy intellects, observe the teaching that is hidden here beneath the veil of verses so obscure
- Dante, Inferno, Canto IX, 61-64
©2011 MFMER |
slide-31
Picano E BMJ 2004;329:849-851
SAFETY
Results of EvaluationCar Travel Time to Reach 5 mSv doseCondition Max Activity Max Car Travel Time
Hyperthyroidism Up to 33 mCi 72 hours*
Post-thyroidectomy thyroid carcinoma
150 mCi 24 hours
160 mCi 17 hours
170 mCi 13 hours
180 mCi 10 hours
190 mCi 8 hours
200 mCi 7 hours
* We only allow up to 24 hour car travel.
SAFETY
ResultsAir Travel Hyperthyroidism – 1 mSv External Dose
Maximum Air Travel Time Permissible With:
Max Activity No Delay One Day Delay Two Days Delay
10 mCi > 24 hours NA NA
15 mCi 15 hours 20 hours >24 hours
20 mCi 11 hours 15 hours 17 hours
25 mCi 8 hours 12 hours 14 hours
33 mCi 9 hours 10 hours 12 hours
SAFETY
ResultsAir Travel Post-thyroidectomy Thyroid Carcinoma – 1 mSv External Dose
Maximum Air Travel Time Permissible With:
Max Activity No Delay One Day Delay Two Days Delay
150 mCi 1 hour 9 hours >24 hours
160 mCi 1 hour 9 hours >24 hours
170 mCi 1 hour 8 hours >24 hours
180 mCi 1 hour 7 hours >24 hours
190 mCi 1 hour 7 hours >24 hours
200 mCi 1 hour 6 hours 23 hours
SAFETY
Patient Instructions (>33 mCi 131I)
SAFETY
HPS PS027-0
RELEASE OF PATIENTS TREATED WITH
THERAPEUTIC QUANTITIES OF
RADIOPHARMACEUTICALS AND SEALED SOURCES
POSITION STATEMENT OF THE HEALTH
PHYSICS SOCIETY
March 2012
SAFETY
HPS PS027-0
Algorithms recommended in NRC guidance … are conservative in overestimating those doses
SAFETY
HPS PS027-0
Studies measuring dose to family members … have demonstrated that actual doses received are small and well below the patient release dose criteria.
SAFETY
HPS PS027-0
The Health Physics Society maintains that release of patients … poses no discernible risk to the public … and provides significant benefits to patients, their families, and society.
SAFETY©2011 MFMER |
slide-40
SAFETY©2011 MFMER |
slide-41