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Page 1: r7 ~~r - Science · Threeways to give yourself moretime for research: eeptrack ofyour budgetswith Grant Manager. Ano-nonsenseaccountingandordering system forinvestigators anddepartments

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Page 2: r7 ~~r - Science · Threeways to give yourself moretime for research: eeptrack ofyour budgetswith Grant Manager. Ano-nonsenseaccountingandordering system forinvestigators anddepartments

The BeckmanAnswer forDNA SequencingAutomation

As DNA sequencing work increases,so does the need for automation.Beckman's answer? The Biomek 1000Automated Laboratory Workstation.Single-handedly it automates the frag-mentation steps of the Sanger/Coulsonprotocol for both fluorescent andradiolabeled sequencing.

Increase ThroughputWith the Biomek, you can process24 templates in under 45 minutes.That's36,000 base pairs per day!

Eliminate Placement ErrorsTo process 24 templates requires morethan 450 pipettings-a tedious, error-prone process. But give the job toBiomek and each step is performed withpredictable precision, and no place-ment errors.

Pipette Volumes Down to 1.5 pLEssential for your DNA sequencingwork, the Biomek performs micro-volume pipetting, handling even viscoussolutions with ease.

Call for details! Phone 800/742-2345,or write to Beckman Instruments, Inc.,1050 Page Mill Road, Palo Alto, CA94304. Offices in major cities worldwide.

BECKIMANA SMITHKLINE BECKMAN COMPANY

GemSeq is a registered trademark of PromegaBiotec. K/RT Gemini and pGEM are trademarks ofPromega Biotec.

© 1989 Beckman Instruments, Inc,

Circle No. 196 on Readers' Service Card

Page 3: r7 ~~r - Science · Threeways to give yourself moretime for research: eeptrack ofyour budgetswith Grant Manager. Ano-nonsenseaccountingandordering system forinvestigators anddepartments

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All Rights Reserved. Printed in USA

Circle No. 22 on Readers' Service Card

0

Page 4: r7 ~~r - Science · Threeways to give yourself moretime for research: eeptrack ofyour budgetswith Grant Manager. Ano-nonsenseaccountingandordering system forinvestigators anddepartments

-; * t; 7 ~~~~~0 0 fa-;/7~00 0%..OferI IIk. I

Ililk~~~~~~~~~~~~~Superior Service And Quality Peptides

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Spotting quality peptides iseasy if you focus on the rightsource - Bachem Inc. Ourpeptides of peak purity and bio -

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introduction of new peptides.The result is the widest selec-tion of the most up-to-datesynthetic and recombinantproducts including:. Human Defensin HNP-2. Endothelins. Urodilatin. Recombinant EGF, TNF, 11-2and 11-6

. New resins and reagents forpeptide synthesisWhy look any further when

Bachem provides uncompromis-ing quality and service at suchcompetitive prices? Call ustoday to obtain a copy of ourcatalog or for detailed informa-tion on any of our products.Circle No. 170 on Readers' Service Card

Then set your sights on success-ful research.

b BACHEMINCCFINE CHEMICALS

BACHEM INC.3132 Kashiwa StreetTorrance, CA 90505Telephone (213) 539-4171TWX 910-347-7320 BACHEM TRNCTelefax (213) 530-1571

BACHEM (UK), LTD.69 High StreetSaffron WaldenEssex CB10 1AA, EnglandTelephone (0799) 26465TLX 817205 BACHEM GTelefax (0799) 26351EUSSENDORF BIOCHEMICALS, GmbHA subsidiary of Bachem, Inc.Feodor-Lynen-Strasse 53000 Hannover 61West GermanyTelephone (0511) 530040Telex 9230534 bp dTelefax (0511) 5300479

Page 5: r7 ~~r - Science · Threeways to give yourself moretime for research: eeptrack ofyour budgetswith Grant Manager. Ano-nonsenseaccountingandordering system forinvestigators anddepartments

Announcinga unique RIA_technology- it's_in closer proximity_than you think*No liquid scintillation cocktails required*Time saving0 Cost saving* Increased safety*High performance

Amersham introduces Scintillation Proximity Assays* No separation of bound from free required* Simple to use; convenient protocol* Readily automatable

Full details on the theoretical and technical aspects of scintillation proximityassays are given in our technical booklet 'Scintillation Proximity Assays-principles and practice', available on request.

Products available* Generic reagents - for the development ofin-house assays Ordering codeScintillation Proximity Assay (SPA) reagent, anti-rabbit RPN 140Scintillation Proximity Assay (SPA) reagent, anti-mouse RPN 141Scintillation Proximity Assay (SPA) reagent, anti-sheep RPN 142Scintillation Proximity Assay (SPA) reagent, protein A RPN 143

* Assay systems6-Keto-prostaglandin F,1 [H] Scintillation ProximityAssay (SPA) system TRK 952Thromboxane B2 [3H] Scintillation Proximity Assay(SPA) system TRK 951

Amersham International picAmershamUK Amers,amUK Sales Aylesbury (0296) 395222 Ameham Australla PTY Ltd Sydney 888-2288 Amersham Beigium SA/NV Brussels (02) 770 0075Amersham Buchier GmbH & Co KG Braunschweig West Germany (05307) 8080 Amersham Canada Ltd Oakville, ONT (416)842 2720Amersham Corporation Arlington Heights, IL USA (312) 364 7100 Amersham Denmark ApS Birkerod 02-8202 22 Amersham France SA Paris (1) 69.28.83.00Amersham Japan Tokyo (03) 816 6161 Amesham Nedland BV Houten 03403 76660 Amersham Norway Sandvika 02-54 63 18Amersham Sweden AB Solna 08-734 08 00

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X-rays, maps, and more - using Save hundreds oho a oytour own PC. mlanual mesurement techniques.* Areas, lengths, angles, and slopes Automate complex analyses. Come.* X,Y digitizing complete with software, choice of* User-defined units digitizing tablet, money-back guara,* Standard ASCII data output and full year hardware warranty.(use in Lotus, dBase, etc.)

* Keyboard macros Sigma-Scan.w software is also* User-deFined data transforms available separately.

Circle No. 224 on Readers' Service Card

When you need the instrument fast.When your long-term needs are uncertain.When you lack capital for new instrumentation.

USAI is The Alternative.

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At Synthecell,We Foresaw the Need...

and RespondedIntroducing

S-OLIGOSAnti-Sense DNA

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Page 7: r7 ~~r - Science · Threeways to give yourself moretime for research: eeptrack ofyour budgetswith Grant Manager. Ano-nonsenseaccountingandordering system forinvestigators anddepartments

ONEMINUTE to accomplish magnetic separation ofrosetted cells.

A new technique can give you a new way of obtaining experimental results. Or, a fasterand easier way of handling routine preparative procedures. DYNABEADS can give youadvantages for both new and routine bioseparation applications.The simple, reliable, immunomagnetic DYNABEADS separation is very fast. Binding

and specific rosetting of cells, microorganisms, or organelles, with subsequent magneticseparation, can be accomplished in the same test tube. When you combine the speed ofmagnetic separation with the specificity of monoclonal antibody-coated DYNABEADSyou have a new and powerful research tool.DYNABEADS have been used in many biotechnology applications: immunology, trans-

plantation, cancer research, microbiology, virology, and pathology.If your work calls for bioseparations, call for DYNABEADS to speed up and simplify

your research work.

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Dynal A.S. (International Headquarters)PO. Box 158, Skoyen N-0212, Oslo 2, NorwayTel. (472) 50 78 00Fax. (472) 50 58 60Tlx. 79133 dynal n

SubsidiariesU.S.: Dynal, Inc., Great Neck, NY Tel. (516) 829-0039U.K.: Dynal (U.K.) Ltd., New Ferry, Wirral, Tel. (051) 644 65 55Japan: Nihon Dynal K.K., Akasaka, Tokyo, Tel. (03) 585-0225

DistributorsAustralia: BDH, Kilsyth, Vic., Tel. (03) 728 5855France: Biosys S.A., Compiegne, Tel. (044) 86 22 75Germany: Dianova Gmbh, Hamburg, Tel. (040) 410 50 91Italy: Oxoid Italiana, Milano, (02) 995 5651

Circle No. 190 on Readers' Service Card

Page 8: r7 ~~r - Science · Threeways to give yourself moretime for research: eeptrack ofyour budgetswith Grant Manager. Ano-nonsenseaccountingandordering system forinvestigators anddepartments

Three ways to give yourself

more time for research:

eep track of yourbudgets withGrant Manager.

A no-nonsense accounting and orderingsystem for investigators and departments.Type orders into your computer, and let

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For IBM PC and compatibles. Requires512K RAM. $425. Demo - $10.

Idd bibliographicpower to your wordprocessor withEndNote.

Still typing bibliographies on yourMacintosh? EndNote will do them for you.You can store up to 32,000 references in

EndNote's database. There's plenty of room forinformation. For example: up to 32,000characters of abstracts for each reference!Searching is simple and extremely fast.EndNote works with Microsoft Word, Wri-

teNow, WordPerfect and MacWrite. Use thedesk accessory to access the database while youwrite. Copy citations like [Smith, 1986] fromyour database and paste them into your text.When you finish writing, select a bibliograph-ic style, and EndNote does the rest: It scans thepaper, finds the citations you pasted, and adds a

perfectly formatted bibliography to the end ofyour paper. It even replaces the in-text cita-tions with numbers or (author, date).

For Macintosh 512KE,Plus, SE, II or lIx. $129.Demo - $5.

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For Grant Manager or Personnel circle no1O on readers' service card. For EndNote circle no.11 on readers' service card.

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The foss1 l In question s generelly regarded to be the 220million year-old remains o1 t,'rano*ourus Several years agohovever this hypotheala Va6 overturned by the discovery ofyet another species vhich is nov theuSdlaputed progeny (Argus 1984 011. Turnhouse. 1987 041 o8the species ,. .ma3ml q5 Paleo LibrarVIrom centre | Showing 1 143 references out of 1 143Where the o liloaki 1907 Triceratops ectinction linkemytha tery iloi 1960 R stochastic model of the pSome think lowStein 1984 Micro-mammal prototypesSchertz 1 Jones 1976 The TheorV of roroagngcurrently 1that the em(Whitieg, I Scwrtz 1976 Euoluing ecosgstems: role l1

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Page 9: r7 ~~r - Science · Threeways to give yourself moretime for research: eeptrack ofyour budgetswith Grant Manager. Ano-nonsenseaccountingandordering system forinvestigators anddepartments

ANALYZING ONLY A HANDFULOF EIA PLATES PER WEEK?

Use yourhandsto save thousands on aMicroplate Reader.

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Biotechnology and theNew AgriculturalRevolutionEdited by Joseph J. Molnar and HenryKinnucan, Auburn UniversityThe world's food and fiber production has beenpermanently altered by new ways to manFpulatethe characteristics of plants, animals, andmicrobes. These innovations have raisedimportant questions regarding ownership ofintellectual property, safety and environmentalimpact, and ways to regulate the new technology.

This book examines the impact of biotechnologyon agricultural institutions, agribusiness, andfarmers. It also presents new perspectives on ourconcept of life origins and explores the socialconsequences of this "Green Revolution."

$27.50; AAAS members $22.00 (include membership numberfrom Science). 288 pp., 1989. AAAS Selected Symposium 108.

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Page 10: r7 ~~r - Science · Threeways to give yourself moretime for research: eeptrack ofyour budgetswith Grant Manager. Ano-nonsenseaccountingandordering system forinvestigators anddepartments

CAS Registry Number, that is. And now CAS Registry Numbersare available on BIOSIS Previews/RN, exclusively through STNInternationalR.It's BIOSIS Previews" enhanced with Registry Numbers (RNs)issued by the Chemical Abstracts Service Chemical RegistrySystem. This new feature allows you to search for chemicalnames without the use of chemical nomenclature or a variety ofsynonyms. Just enter the CAS Registry Number to retrieve docu-ments where the chemical appears in the article title orsupplementary index terms. Or transfer answer sets from theRegistry file on STN to retrieve additional information fromBIOSIS Previews/RN.Approximately 1,400,000 records from July 1980 to date now con-tain a CAS Registry Number. Plus, 58,000 substances have beenidentified as derivative compounds.

Your number is up and available on BIOSIS Previews/RNthrough STN, making your biomedical searching faster, easierand more economical.

For more information contact BIOSIS, Marketing Section, 2100Arch Street, Dept. S689NU, Philadelphia, PA 19103-1399; orcall toll free 1-800-523-4806 (USA except PA); (215) 587-4800(worldwide). Or call STN International at 1-800-848-6538, ext.3731.STN International is a registered trademark of the American Chemical Society.BIOSIS Previews is a registered trademark of BIOSIS.BIOSIS is a registered trademark of Biological Abstracts Inc.

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Circle No. 81 on Readers' Service Card