R Tuli MD PhD, JP Christodouleas MD MPH, L Roberts, SJ Deol, DA Frassica MD,

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    17-Jan-2016

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Method of Detection of Ipsilateral Breast Tumor Recurrence Following Breast Conserving Therapy is a Predictor of Distant Metastases. R Tuli MD PhD, JP Christodouleas MD MPH, L Roberts, SJ Deol, DA Frassica MD, RC Zellars MD, KY Usuki MD, KL Brill MD, AL Rosenberg MD. Background. - PowerPoint PPT Presentation

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<ul><li><p>Method of Detection of Ipsilateral Breast Tumor Recurrence Following Breast Conserving Therapy is a Predictor of Distant Metastases R Tuli MD PhD, JP Christodouleas MD MPH, L Roberts, SJ Deol, DA Frassica MD, RC Zellars MD, KY Usuki MD, KL Brill MD, AL Rosenberg MD</p></li><li><p>BackgroundCurrent clinical guidelines suggest the method of detection (clinical vs. radiographic) of ipsilateral breast tumor recurrence (IBTR) following breast conserving therapy (BCT) does not influence survival Controversy exists regarding the optimal surveillance of such patients PurposeWe attempt to determine the prognostic significance of method of detection of IBTR on distant metastases (DM)-free survival Author Disclosures: None</p></li><li><p>MethodsIRB approved, retrospective single institution chart review of all newly diagnosed breast cancer patients Treated with BCT between 1981 and 2007We identified patients who subsequently developed IBTR Charts reviewed for: DemographicsClinical presentationMethod of detectionStageType of therapyHistopathologyMargin status (primary and recurrent tumors) All patients presenting with DM following BCT or a suspected new primary with different histology following BCT were excluded </p></li><li><p>Median follow-up from time of recurrence 27 months (1 to 231)Median time from IBTR to DM was 151 months5-year DM-free survival following IBTR was 69.5%Results</p></li><li><p>ResultsUnivariate analysis of pt/tumor characteristics on DM-free survival</p></li><li><p>Contrary to previous reports, clinical detection of local recurrence remains a significant risk factor for time to DMIn contrast, radiographic detection of such recurrences confers a higher DM-free survivalThese results support the necessity for regular and timely radiographic evaluations following IBTR in patients previously treated with BCT Median DM-free survival for clinically and radiographically detected IBTRs was 54 months and &gt; 231 months (median was not reached), respectivelyOn multivariate Cox regression analysis, clinically detected IBTRs remained a significant predictor of lower DM-free survivalAdjusted relative risk for clinically detected IBTRs was 2.2 ResultsConclusions</p><p>******</p></li></ul>

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