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PUBLICATIONS FOR LESLIE J. DEGROOT, M.D.

1956 - 2004 1. Greer MA, DeGroot LJ. The effect of stable iodide on thyroid secretion in man. Metabolism

5:682-696, 1956. 2. DeGroot LJ, Postel S, Litvak J, Stanbury JB. Peptide-linked iodotyrosines and

iodothyronines in the blood of a patient with congenital goiter. J Clin Endocrinol Metab 18:158-166, 1958.

3. DeGroot LJ. Physiology of the thyroid gland. Postgraduate Med 24:170-178, 1958. 4. DeGroot LJ, Stanbury JB. The syndrome of congenital goiter with butanol-insoluble serum

iodide. Am J Med 28:586-595, 1959. 5. Courvoisier B, DeGroot LJ, Stanbury JB, Beraud T, Koralnik L. Insufficances thyroidiennes

par anomalies congenitales de la synthese hormonale. Schwz Med Wschr 38:973,1959. 6. DeGroot LJ, Carvalho E. Studies on proteins of normal and diseased thyroid glands. J Clin

Endocrinol Metab 20:21-34, 1960. 7. DeGroot LJ. Thyroid Function tests. Syllabus of laboratory examinations in clinical

diagnosis. Page L, Culver PJ, editors. Harvard University Press, Cambridge, 1960, pages 475-485.

8. DeGroot LJ, Carvalho E. Iodide binding by thyroid cellular fractions. J Biol Chem 235:1390-1397, 1960.

9. DeGroot LJ, Berger JE. A note on inorganic oxidation products of 131-I formed in biological systems. Endocrinology 67:657-662, 1960.

10. DeGroot LJ, Davis AM. A soluble thyroidal peroxidase-iodinase system. J Clin Invest 40:1032, 1961.

11. DeGroot LJ, Davis AM. Studies on the biosynthesis of iodotyosines. J Biol Chem 236:2009-2014, 1961.

12. DeGroot LJ, Davis AM. The early phase of thyroid hormone formation: Studies in tissue slices. Endocrinology 69:683-694, 1961.

13. DeGroot LJ, Davis AM. The early stage of thyroid hormone formation: Studies on rat thyroids in vivo. Endocrinology 69:695-705, 1961.

14. DeGroot LJ, Davis AM. Studies on the biosynthesis of iodotyrosines: A soluble thyroidal iodide-peroxidase tyrosine-iodinase system. Endocrinology, 70:492-504, 1962.

15. Nava M, DeGroot LJ. Resn uptake of 131-I labeled tiiodothyronine as a test of thyroid function. New Engl J Med 266:1307-1310, 1962.

16. DeGroot LJ, Davis AM. Studies on the biosynthesis of iodotyrosines: the relationship of peroxidase, catalase, and cytochrome oxidase. Endocrinology 70:505-510, 1962.

17. DeGroot LJ, Hall R, McDermott WV Jr, Davis AM. Hashimoto’s thyroiditis: a genetically conditioned disease. New Engl J Med 267:267-273, 1962.

18. DeGroot LJ, Davis AM. Studies on the biosynthesis of iodotyrosines: reduced pyridine nucleotide peroxidation by a thyroidal-iodinating enzyme. Biochim Biophys Acta 59:581-588, 1962.

19. Means JH, DeGroot LJ, Stanbury JB. The Thyroid and Its Diseases (Third Edition). McGraw-Hill Book Co Inc, New York, 1963, 598 pages.

20. DeGroot LJ. Therapy of Thyrotoxicosis. Modern Treatment 1:176-207, 1964. 21. DeGroot LJ. Thyroid hormone formation in health and disease. Penn Med J 67:25-29, 1964. 22. Greenberger NJ, Milligan FD, DeGroot LJ, Isselbacher KJ. Jaundice and thyrotoxicosis in

the absence of congestive heart failure. Am J Med 36:840-846, 1964.

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23. Stanbury JB, DeGroot LJ. Problem of hypothyroidism after 131-I therapy of hyperthyroidism. New Engl J Med 271:195-196, 1964.

24. DeGroot LJ. Thyroid hormone biosynthesis: Mechanisms involved and relation to the general metabolism of the thyroid. Proceedings of the Second International Congress of Endocrinology, Amsterdam, Excerpta Medica Foundation, 1964.

25. DeGroot LJ, Dunn AD. Electron transport enzymes of calf thyroid. Biochim Biophys Acta 92:205-222, 1964.

26. DeGroot LJ, Dechene R, Thompson J. Thyroid D-T diaphorase. Biochim Biophys Acta 92:223-232, 1964.

27. DeGroot LJ. Thyroiditis. Current Therapy, Conn H, editor. WB Saunders, Philadelphia, 1965, pages 354-355.

28. DeGroot LJ. Current views on formation of thyroid hormones. New Engl J Med 272:243-250, 297-303, and 355-362, 1965.

29. DeGroot LJ, Thompson JE, Dunn AD. Studies on an iodinating enzyme fom calf thyroid. Endocrinology 76:632-645, 1965.

30. DeGroot LJ. Thyroid iodine kinetics and evidence for an iodide leak. J Clin Invest 44:1039, 1965.

31. Pretell EA, DeGroot LJ, Vickery AL. Penetration of albumin into the thyroid gland. Proceedings of the Fifth International Thyroid Conference, Rome, 1965. Academic Press, New York, 1965.

32. DeGroot LJ, Dunn AD. Thyroid mitochondrial respiration. Proceedings of the Fifth International Thyroid Conference, Rome, 1965. Academic Press, New York, 1965.

33. DeGroot LJ, Pretell EA, Garcia ME. Adsorption of intramuscularly administered triiodothyronine. New Engl J Med 274:133-135, 1966.

34. DeGroot LJ. Kinetic analysis of iodine metabolism. J Clin Endocrinol Metab 26:149-173, 1966.

35. DeGroot LJ. A brief look at the management of hyperthyroidism. Alabama J Med Sci 3:172-174, 1966.

36. DeGroot LJ, Dunn AD. Response of rat thyroid oxidative enzymes to TSH. Endocrinology 78:1032-1036, 1966.

37. DeGroot LJ. Action of potassium iodide on thyroxine metabolism. J Clin Endocrinol Metab 26:778-779, 1966.

38. DeGroot LJ, Dunn AD, Jaksina S. Thyroid mitochondrial respiration. Endocrinology 79:28-37, 1966.

39. DeGroot LJ, editor. Medical Care: Social and Organizational Aspects. Charles C. Thomas Publisher, Springfield, IL, 1966, 538 pages.

40. Means JH, DeGroot LJ, Stanbury JB. Enfermedades del Tiroides. Barcelona, Espana, Ediciones Toray, South America, 1966, 620 pages.

41. Refetoff S, DeWind LT, DeGroot LJ. Familial syndrome combining deaf-mutism, stippled epiphyses, goiter, and abnormally high PBI: possible target organ refractoriness to thyroid hormone. J Clin Endocrinol Metab 27:279-294, 1967.

42. DeGroot LJ. Stimulation and inhibition of thyroid iodinating enzyme systems. Biochim Biophys Acta 136:364-374, 1967.

43. Stanbury JB, DeGroot LJ. The clinical chemistry and pathologic physiology of thyroid tissue. Clin Chem 13:542-553, 1967.

44. Fierro-Benitez R, DeGroot LJ. Paredes-Suarez M, Penafield W, Yudo, bocio y cretinismo endemicos en la region andina del Ecuador. Reimpreso de Revista Ecuatoriana de Medicina y Ciencas Biologicas, Vol. V, No. 1, Ene-Mar, 1967, pages 15-30.

45. DeGroot LJ. Graves’ disease and Vitamin B12 malabsorption. New Engl J Med 277:269, 1967.

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46. DeGroot LJ, Bransome E, Stanbury JB, Wurtman RJ. Advances in endocrinology. Practitioner 199:485-497, 1967.

47. DeGroot LJ, Perlo V, Gephart T, Schwab R. Remission of myasthenia and thyrotoxicosis after thymectomy. Ann Int Med 67:1042-1044, 1967.

48. Pretell EA, DeGroot LJ, Vickery AL. Albumin penetration into the rat thyroid gland. Endocrinology 82:1103-1116, 1968.

49. Stocker WW, Samaha FJ, DeGroot LJ. Coupled oxidative phosphorylation in muscle of thyrotoxic patients. Amer J Med 44:900-909, 1968.

50. Benard B, DeGroot LJ. Hypothyroidism. Current Diagnosis, Conn H, editor. WB Saunders, 1968.

51. Ochi Y, DeGroot LJ. Studies on the immunological properties of LATS. Endocrinology 83:845-854, 1968.

52. Ochi Y, DeGroot LJ. Long acting thyroid stimulator of Graves’ disease. New Engl J Med 278:718-721, 1968.

53. DeGroot LJ. Iodide excretion during short-term fasting. J Clin Endocrinol Metab 28:919-920, 1968.

54. DeGroot LJ, Jaksina S, Karmarkar M. The role of pyridoxal phosphate in thyroid hormone biosynthesis. Endocrinology 83:1253-1258, 1968.

55. Ochi Y, DeGroot LJ. Stimulation of RNA and phospholipid synthesis by Long Acting Thyroid Stimulator and by Thyroid Stimulating Hormone. Biochim Biophys Acta 170:198-201, 1968.

56. DeGroot LJ, Matovinovic J. The relation of the nucleic acids and nitrogen content of the thyroid tissue subcellular fractions to the synthesis of iodotyrosine in vitro. Arq Brss Endocrinol Metab 17:47-53, 1968.

57. DeGroot LJ. Kinetics of iodine metabolism. Primer Coloquio Argentino de Hormonas Tiroideas. Comision Nacional de Energia Atomica, Buenos Aires, Argentina, page 9, 1968.

58. DeGroot LJ. Mechanism of action of thyroid stimulating hormone. Primer Coloquio Agentino de Hormonas Tiroideas. Comision Nacional de Energia Atomica, Buenos Aires, Argentina, page 87, 1968.

59. Fierro-Benitez R, DeGroot LJ, Paredes M, Penafiel W. Endemic goiter and endemic cretinism in the Andean region. New Engl J Med 280:296-302, 1969.

60. DeGroot LJ, Jaksina S. Observations on the role of circulating lymphocytes in thyroid autoimmunity. J Clin Endocrinol Metab 29:207-212, 1969.

61. Refetoff S, DeGroot LJ. Hyperthyroidism. Current Therapy, Conn H, editor. WB Saunders, 1969, pages 456-460.

62. DeCostre PL, Phair RD, Dingwell IW, DeGroot LJ. A thyroid model and its analysis by computer. Endemic Goiter, Stanbury JB, editor. Scientific Publication No. 193 of PAHO-WHO, Washington DC, 1969, pages 49-66.

63. Ochi Y, DeGroot LJ. Effect of adenine nucleotides on thyroid hormone release in vivo and in vitro. Metabolism 18:331-338, 1969.

64. Ochi Y, DeGroot LJ. TSH or LATS stimulated thyroid hormone release is inhibited by iodide. Endocrinology 84:1305-1309, 1969.

65. Ochi Y, DeGroot LJ. Stimulation of thyroid hyperplasia and protein synthesis by LATS. Endocrinology 85:344-347, 1969.

66. DeGroot LJ, Jaksina S. Inhibition of iodotyrosine formation by analogs of tyrosine. J Lab Clin Med 74:257-264, 1969.

67. Benard B, DeGroot LJ. The role of hydrogen peroxide and glutathione in glucose oxidation by the thyroid. Biochim Biophys Acta 184:48-53, 1969.

68. Ochi Y, DeGroot LJ. Vitiligo in Graves’ disease. Ann Int Med 71:935-940, 1969. 69. Buhler U, DeGroot LJ. Effect of stable iodine on thyroid iodine release. J Clin Endocrinol

Metab 29:1546-1552, 1969.

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70. Pisarev MA, Utiger RD, Salvaneschi JP, Altschuler N, DeGroot LJ. Serum TSH and thyroxine in goitrous subjects in Argentina. J Clin Endocrinol Metab 30:680-681, 1970.

71. DeGroot LJ. Current concepts in the management of thyroid disease. Med Clin North America, Meier A, editor. WB Saunders Co, Vol 54, 1970, pages 117-130.

72. Pisarev MA, DeGroot LJ, Wilber JF. Cyclic-AMP production of goiter. Endocrinology 87:339-342, 1970.

73. Fierro-Benitez R, Stanbury JB, Querido A, DeGroot LJ, Alban R, Cordova J. Endemic cretinism in the Andean region of Ecuador. J Clin Endocrinol Metab 30:228, 1970.

74. Ochi Y, DeGroot LJ. Comparative studies on the properties of LATS and TSH. Endocrinol Japon 17:131-141, 1970.

75. DeGroot LJ, Nagasaka A, Hati R, Bigazzi M, Rapoport B, Refetoff S. Biosynthesis of thyroid hormone. Proceedings of the VII Congresso Pan Americano de Endocrinologia, Sao Paulo, Brazil. Excerpta Medica International Congress, Series No. 238, 1970, pages 53-62.

76. Hidaka H, Udenfriend S, Nagasaka A, DeGroot LJ. Inhibition of thyroid peroxidase in vivo and in vitro by Iproniazid. Biochem Biophys Res Commun 40:103-109, 1970.

77. DeGroot LJ. Lack of iodide trapping in “cold” thyroid nodules. Acta Endocrinologica Pan Americana 1:27-31, 1970.

78. Pisarev MA, DeGroot LJ. Recent advances in endocrine exophthalmos. Acta Endocrinologica Pan Americana 1:171-178, 1970.

79. Pisarev MA, DeGroot LJ, Hati R. KI and Imidazole inhibition of TSH and camp-induced thyroidal iodine secretion. Endocrinology 88:1217-1221, 1971.

80. DeGroot LJ. Diseases of the thyroid. Chapter in Cecil Loeb Textbook of Medicine. Beeson PB, McDermott W, editors. WB Saunders Co, 1971, pages 1753-1780.

81. Pisarev MA, DeGroot LJ, Wilber JF, Altschuler N. Action of cyclic guanosine monophosphate on thyroid weight and protein. Endocrinology 88:1074-1076, 1971.

82. Nagasaka A, DeGroot LJ, Hati R. Studies on the biosynthesis of thyroid hormone: reconstruction of a defined in vitro iodinating system. Endocrinology 88:486-490, 1971.

83. Nagasaka A, DeGroot LJ. Studies on the biosynthesis of thyroid hormone: bulk fractionation procedures and absorbency spectra of calf thyroid: iodide-peroxidase-tyrosine iodinase; stabilization of enzyme and polymeric structure. Endocrinology 88:470-485, 1971.

84. Pisarev MA, DeGroot LJ, Wilber JF. Regulation of protein synthesis in the thyroid: role of cyclic nucleotides. Further Advances in Thyroid Research, Fellinger K, Hofer R, editors. Verlag der Wiener Medizinischen Akademie, Vienna, 1971, pages 297-306.

85. DeGroot LJ, Nagasaka A. Biosynthesis of thyroid hormone: polymeric structure of enzyme and mechanism of H2O2 generation for peroxidation. Further Advances in Thyroid Research, Fellinger K, Hofer R, editors. Verlag der Wiener Medizinischen Akademie, Vienna, 1971, pages 413-421.

86. Ochi Y, DeGroot LJ. Isolation of thyroidal acid protease and immunological analysis of its antibody. Endocrinol Japon 18:109-116, 1971.

87. DeGroot LJ, DeCostre P, Phair R. A mathematical model of human iodine metabolism. J Clin Endocrinol Metab 32:757-765, 1971.

88. DeGroot LJ, Klotz LJ. Therapeutic effectiveness of synthetic thyroxine-triiodothyronine mixtures. Current Therapeutic Res 13:234-239, 1971.

89. Hidaka H, Nagasaka A, DeGroot LJ. Inhibition of thyroid iodide peroxidase by hydrazines and NSD-1055 (4-bromo-3-hydroxybenzyloxyamine). Endocrinology 88:1264-1266, 1971.

90. Rapoport B, DeGroot LJ. Current concepts of thyroid physiology. Sem Nuc Med 1:265-286, 1971.

91. Calman NS, Pysher TJ, DeGroot LJ, Cohen EP. The inhibition in vitro of cell-mediated immune reactions in patients bearing neoplastic diseases. Proceedings of the Sixth Leukocyte Conference, Schazz R, editor, Academic Press, 1971.

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92. DeCostre P, Buhler U, DeGroot LJ, Refetoff S. Diurnal rhythm in total serum thyroxine levels. Metabolism 20:782-791, 1971.

93. Hagen GA, Niepomniszcze H, Haibach H, Bigazzi M, Hati RN, Rapoport B, Jimenez C, DeGroot LJ, Frawley TF. Peroxidase deficiency in familial goiter with iodide organification defect. New Engl J Med 285:1394-1398, 1971.

94. DeGroot LJ, Buhler U. Effect of perchlorate and methimazole on iodine metabolism. Acta Endocrinol 68:696-706, 1971.

95. Pisarev MA, Altschuler N, DeGroot LJ. Studies on thyroidal colloid pinocytosis using a double isotope technique. Acta Endocrinol 70:48-55, 1972.

96. DeGroot LJ, Niepomniszcze H, Nagasaka A, Hati RN. Mechanism of thyroid hormone formation. Ann Clin Res 4:113-120, 1972.

97. Niepomniszcze H, DeGroot LJ, Hagen GA. Abnormal thyroid peroxidase causing iodide organification defect. J Clin Endocrinol Metab 34:607-616, 1972.

98. Rapoport B, DeGroot LJ. Cyclic nucleotide dependent protein kinase in the thyroid: partial purification and characterization. Endocrinology 91:1259-1266, 1972.

99. Rapoport B, Niepomniszcze H, Bigazzi M, Hati RN, DeGroot LJ. Studies on the pathogenesis of poor thyroglobulin iodination in non-toxic multinodular goiter. J Clin Endocrinol Metab 34:822-830, 1972.

100. Solomon DH, Benotti J, DeGroot LJ, Greer MA, Pileggi VJ, Pittman JA, Robbins J, Selenkow HA, Sterling K, Volpe R. A nomenclature for tests of thyroid hormones in serum: report of a committee of the American Thyroid Association. J Clin Endocrinol Metab 34:884, 1972.

101. Refetoff S, DeGroot LJ, Benard B, DeWind LT. Studies of a sibship with apparent hereditary resistance to the intracellular action of thyroid hormone. Metabolism 21:723-756, 1972.

102. DeGroot LJ. Thyroid and the heart. Mayo Clin Proc 47:864-871, 1972. 103. Hati RN, DeGroot LJ. Studies on the mechanism of iodination supported by thyroid

NADPH-cytochrome c reductase. Acta Endocrinol 74:271-282, 1973. 104. Niepomniszcze H, DeGroot LJ. p-Hydroxyphenylpuruvic acid is a substrate of thyroid

iodide peroxidase. Acta Endocrinol Panam 4:51-73, 1973. 105. Bigazzi M, DeGroot LJ. Redistribution of iodoprotein, acid phosphatase, and acid

protease in thyroid subcellular fractions during endocytosis. Endocrinology 92:1761-1767, 1973.

106. Refetoff S, DeGroot LJ. Genetic defects in hormone synthesis and action. Handbook of Physiology-Endocrinology, Vol. III, Chapter 10. American Physiological Soc, Washington, DC, 1973, pages 161-178.

107. Niepomniszcze H, Castells S, DeGroot LJ, Refetoff S, Kim OS, Rapoport B, Hati RN. Peroxidase defect in congenital goiter with complete organification block. J Clin Endocrinol Metab 36:347-357, 1973.

108. Rapoport B, Block MB, Hoffer PB, DeGroot LJ. Depletion of thyroid iodine during subacute thyroiditis. J Clin Endocrinol Metab 36:610-611, 1973.

109. Amino N, DeGroot LJ. A sensitive microassay system for lymphocyte-mediated cytotoxicity (lymphotoxin) induced by PHA and PPD. J Immunol 111:464-471, 1973.

110. Rapoport B, Caplan R, DeGroot LJ. Low dose sodium iodide 131-I therapy in Graves’ disease. J Amer Med Assn 224:1610-1613, 1973.

111. Porter BA, Refetoff S, Rosenfield RL, DeGroot LJ, Fang VS, Stark V. Abnormal thyroxine metabolism in hyposomatotrophic dwarfism and inhibition of responsiveness to TRH during GH therapy. Pediatrics 51:668-674, 1973.

112. Yamamoto K, DeGroot LJ. Function of peroxidase and NADPH-cytochrome c reductase during the Wolff-Chaikoff effect. Endocrinology 93:822-828, 1973.

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113. DeGroot LJ, Paloyan E. Thyroid carcinoma and radiation: A Chicago endemic. J Amer Med Assn 225:487-491, 1973.

114. Stanbury JB, DeGroot LJ. Cancer of the Thyroid. Methods in Cancer Research, Busch H, editor. Vol. X. Academic Press, New York, Chapter VI, 1973, pages 129-159.

115. Niepomniszcze H, DeGroot LJ. Effects of hematin and globin on thyroid peroxidase. Acta Endocrinol Panam 4:60, 1973.

116. Rosenfield RL, Refetoff S, Hoffer PB, Gottschalk A, DeGroot LJ. The diagnosis of thyroid diseases in children. Pediatric Nuclear Medicine, James AE, Wagner N, Cooke RE, editors. WB Saunders Co, Philadelphia, 1974, pages 376-399.

117. Amino N, DeGroot LJ. Concentation of cultured medium to detect small amounts of lymphotoxin induced by PHA, PPD, and thyroid antigens. Cell Immunol 11:188-197, 1974.

118. DeGroot LJ, Strausser JL. Binding of T3 in rat liver nuclei. Endocrinology 95:74-83, 1974.

119. DeGroot LJ. Most solitary thyroid nodules should be removed. Controversy in Internal Medicine, Ingelfinger FJ, Ebert RV, Finland M, Relman AS, editors. WB Saunders Co, Philadelphia, 1974, pages 421-427.

120. Amino N, Linn E, Pysher TJ, Mier R, Moore GE, DeGroot LJ. Human lymphotoxin obtained from established lymphoid lines: purification characteristics and inhibition by anti-immunoglobulin. J Immunol 113:1334-1345, 1974.

121. Yamamoto K, DeGroot LJ. Peroxidase and NADPH-cytochrome c reductase activity during thyroid hyperplasia and involution. Endocrinology 95:606-612, 1974.

122. DeGroot LJ, Refetoff S, Strausser JL, Barsano C. Nuclear triiodothyronine binding protein: partial characterization and binding to chromatin. Prod Nat Acad Sci 71:4042-4046, 1974.

123. DeGroot LJ. Qualitative biochemical defects in thyroid hormone synthesis and their relation to endemic goiter. In: Endemic goiter and cretinism: continuing threats to world health. PAHO Scientific Publication No. 292, 1974, pages 25-32.

124. Niepomniszcze H, Rosenbloom AL, DeGroot LJ, Shimaoka K, Refetoff S, Yamamoto K. Differentiation of two abnormalities in thyroid peroxidase causing organification defect and goitrous hypothyroidism. Metabolism 24:57-67, 1975.

125. Amino N, DeGroot LJ. Insoluble particulate antigen(s) in cell-mediated immunity of autoimmune thyroid disease. Metabolism 24:45-56, 1975.

126. Amino N, Pysher T, Cohen EP, DeGroot LJ. Immunological aspects of human thyroid cancer: humoral and cell-mediated immunity: tumor specific “common antigen”; trial of immunotherapy. Cancer 36:963-973, 1975.

127. Yamamoto K, DeGroot LJ. Participation of NADPH-cytochrome c reductase in thyroid hormone biosynthesis. Endocrinology 96:1022-1029, 1975.

128. Refetoff S, Harrison JR, Karanfilski BT, Kaplan EL, DeGroot LJ, Bekerman C. Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood. New Eng J Med 292:171-175, 1975.

129. DeGroot LJ, Torresani J. Triiodothyronine binding to isolated liver cell nuclei. Endocrinology 96:357-369, 1975.

130. Torresani J, DeGroot LJ. Triiodothyronine binding to liver nuclear solubilized proteins in vitro. Endocrinology 96:1201-1209, 1975.

131. DeGroot LJ. Thyroid Carcinoma. Med Clin North America 59:1233-1246, 1975. 132. Rochman H, DeGroot LJ, Rieger CHL, Varnavides LA, Refetoff S, Joung JI, Hoye K.

Carcinoembryonic antigen and humoral antibody response in patients with thyroid carcinoma. Cancer Research 35:2689-2692, 1975.

133. DeGroot LJ, Stanbury JB, editors. The Thyroid and Its Diseases, 4th Edition. John Wiley & Sons, New York, 1975, 823 pages.

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134. DeGroot LJ, Torresani J, Carrayon P, Tirard A. Factors influencing T3 binding properties of liver nuclear receptors. Acta Endocrinologica 83:293-304, 1976.

135. DeGroot LJ, Hoye K. Dexamethasone suppression of serum T3 and T4. J Clin Endocrinol Metab 42:976-977, 1976.

136. DeGroot LJ, Hill L, Seo H, Bernal J. Binding of nuclear triiodothyronine binding protein-T3 complex to chromatin. Thyroid Research—Proceedings of the Seventh International Thyroid Conference, Boston, MA, June 9-13, 1975, Robbins J, Braverman LE, editors. Excerpta Medica, Amsterdam, 1976, pages 320-323.

137. Bernal J, DeGroot LJ, Refetoff S, Fang VS, Barsano C. Absent nuclear thyroid hormone receptors and failure of T3-induced TRH suppression in the syndrome of peripheral resistance to thyroid hormone. Thyroid Research—Proceedings of the Seventh International Thyroid Conference, Boston, MA, June 9-13, 1975, Robbins J, Braverman LE, editors. Excerpta Medica Amsterdam, 1976, pages 316-319.

138. DeGroot LJ, Bernal J, Refetoff S. Liver nuclear binding proteins: basic and clinical aspects. In: Biochemical Basis of Thyroid Stimulation and Thyroid Hormone Action, Von Zur Muhlen A, Schleusener H, editors, Georg Thieme Publishers, Stuttgart, 1976, pages 143-156.

139. DeGroot LJ, Hill L, Rue PA. Binding of nuclear triiodothyronine binding protein-T3 complex to chromatin. Endocrinology 99:1605-1611, 1976.

140. Asteris GT, DeGroot LJ. Thyroid cancer: relationship to radiation exposure and to pregnancy. J Reprod Med 17:209-216, 1976.

141. DeGroot LJ. Radiation and thyroid cancer. Proc Inst Med (Chicago) 31:95, 1976. 142. Niepomniszcze H, Medeiros-Neto GA, Refetoff S, DeGroot LJ, Fang VS. Familial goiter

with partial iodine organification defect, lack of thyroglobulin, and high levels of thyroid peroxidase. Clin Endocrinol 6:27-39, 1977.

143. DeGroot LJ, Niepomniszcze H. Biosynthesis of thyroid hormone: basic and clinical aspects. Metabolism 26:665-718, 1977.

144. Barsano CP, DeGroot LJ, Getz GS. The effect of thyroid hormone on in vitro rat liver mitochondrial RNA synthesis. Endocrinology 100:52-60, 1977.

145. DeGroot LJ. Radiation-associated thyroid carcinoma. Thyroid Today 1:1-6, 1977. 146. DeGroot LJ, Frohman LA, Kaplan EL, Refetoff S, editors. Radiation-associated Thyroid

Carcinoma, Grune & Stratton, New York, 1977, 539 pages. 147. Bernal J, DeGroot LJ. Thyroid hormone receptors. Release of receptor to the medium

during in vitro incubation of isolated rat liver nuclei. Endocrinology 100:648-655, 1977. 148. DeGroot LJ, Robertson M, Rue PA. Triiodothyronine receptors during maturation.

Endocrinology 100:1511-1515, 1977. 149. DeGroot LJ. Short-term antithyroid drug therapy. New Engl J Med 297:212, 1977. 150. DeGroot LJ, Rue PA, Robertson M, Bernal J, Scherberg N. Triiodothyronine stimulates

nuclear RNA synthesis. Endocrinology 101:1690-1700, 1977. 151. DeGroot LJ, Hoye K, Refetoff S, Van Herle AJ, Asteris GT, Rochman H. Serum antigens

and antibodies in the diagnosis of thyroid cancer. J Clin Endocrinol Metab 45:1220-1223, 1977.

152. Refetoff S, Demeester-Mirkine N, Ermans AM, DeGroot LJ. Rapid control of thyrotoxicosis with combined 131-I, antithyroid drugs, and potassium iodide therapy. J Nuc Med Allied Sciences 21:23-29, 1977.

153. Roudebush CP, Hoye K, DeGroot LJ. Compensated low dose 131-I therapy of Graves’ disease. Ann Int Med 87:441-443, 1977.

154. DeGroot LJ, Coleoni AH, Rue PA, Seo H, Martino E, Refetoff S. Reduced nuclear triiodothyronine receptors in starvation-induced hypothyroidism. Biochem Biophys Res Commun 79:173-178, 1977.

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155. Roudebush CP, DeGroot LJ. The natural history of radiation-associated thyroid cancer. In: Radiation-associated Thyroid Carcinoma, DeGroot LJ, Frohman LA, Kaplan EL, Refetoff S, editors. Grune & Stratton, New York, 1977, pages 97-118.

156. DeGroot LJ. Nuclear receptors for thyroid hormone. In: Hormone Receptors, Plenum Press, New York, 1977, pages 45-72.

157. Roques M, Tirard A, DeGroot LJ. Liver protein kinase activity and triiodothyronine. Endocrinology 100:967-973, 1977.

158. Bernal J, Coleoni AH, DeGroot LJ. Triiodothyronine stimulation of nuclear protein synthesis. Endocrinology 102:452-459, 1978.

159. Olsen NJ, Fang VS, DeGroot LJ. Cushing’s syndrome due to adrenal adenoma with persistent dirurnal cortisol secretory rhythm. Metabolism 27:695-700, 1978.

160. Bernal J, Coleoni AH, DeGroot LJ. Thyroid hormone receptors from liver nuclei: characteristics of receptor from normal, thyroidectomized, and triiodothyronine-treated rats; measurement of occupied and unoccupied receptors and chromatin binding of receptors. Endocrinology 103:403-413, 1978.

161. Hashizume K, Fenzi G, DeGroot LJ. Thyroglobulin inhibition of thyrotropin binding to thyroid plasma membrane. J Clin Endocrinol Metab 46:679-685, 1978.

162. DeGroot LJ, Refetoff S, Bernal J, Rue PA, Coleoni AH. Nuclear receptors for thyroid hormone. J Endocrinol Invest 1:79-88, 1978.

163. Bernal J, Refetoff S, DeGroot LJ. Abnormalities of triiodothyronine binding to lymphocyte and fibroblast nuclei from a patient with peripheral tissue resistance to thyroid hormone action. J Clin Endocrinol Metab 47:1266-1272, 1978.

164. Roudebush CP, Asteris GT, DeGroot LJ. The natural history of radiation-associated thyroid cancer. Arch Int Med 138:1631-1634, 1978.

165. Fenzi G, Macchia E, Bartalena L, Mazzanti F, Baschieri L, DeGroot LJ. Radioreceptor assay of TSH: Its use to detect thyroid stimulating immunoglobulins. J Endocrinol Invest 1:17-24, 1978.

166. Fenzi G, Hashizume K, Roudebush C, DeGroot LJ. Changes in thyroid stimulating immunoglobulins during antithyroid therapy. J Clin Endocrinol Metab 48:572-576, 1979.

167. DeGroot LJ, Rue PA. T3 receptor occupancy and metabolic responses. J Endocrinol Invest 2:183-189, 1979.

168. DeGroot LJ. Chief Editor, Endocrinology, Volumes I-III, Grune & Stratton, New York, 1979, 2143 pages.

169. Hashizume K, DeGroot LJ. Adenosine 3’5’ monophosphate-dependent protein kinase activiy in soluble thyrotropin receptor complex. Endocrinology 104:1739-1744, 1979.

170. Hashizume K, DeGroot LJ. Cyclic-nucleotide-dependent protein kinase modulators in thyroid tissue. Endocrinology 105:204-209, 1979.

171. Aoki N, Pinnamaneni KM, DeGroot LJ. Studies on suppressor cell function in thyroid diseases. J Clin Endocrinol Metab 48:803-810, 1979.

172. Aoki N, DeGroot LJ. PPD-induced blastogenesis is auto-regulated by suppressor cells generated in vitro. Experientia 35:1515-1517, 1979.

173. DeGroot LJ, Rue PA. Roentgenographic contrast agents inhibit triiodothyronine binding to nuclear receptors in vitro. J Clin Endocrinol Metab 49:538-542, 1979.

174. Mariotti S, DeGroot LJ, Scarborough D, Medof ME. Study of circulating immune complexes in thyroid diseases. Comparison of Raji cell radioimmunoassay and specific thyroglobulin antithyroglobulin radioassay. J Clin Endocrinol Metab 49:679-686, 1979.

175. DeGroot LJ. Mechanism of action of thyroid hormone. In: Proceedings of the International Symposium on Free Thyroid Hormones, Venice, Italy, December, 1978. Edited by Ekins R, Faglia G, Pennisi F, Pinchera A. Excerpta Medica, Amsterdam, 1979, pages 28-45.

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176. Barsano CP, DeGroot LJ. Dyshormonogenetic goiter. Clinics in Endocrinol Metab 8:145-165, 1979.

177. Aoki N, DeGroot LJ. Lymphocyte blastogenic response to human thyroglobulin in Graves’ disease, Hashimoto’s thyroiditis, and metastatic thyroid cancer. Clin Exper Immunol 38:523-530, 1979.

178. DeGroot LJ, Siegler M. The morning-report syndrome and medical search. New Engl J Med 301:1285-1287, 1979.

179. Bernal J, DeGroot LJ. Mode of action of thyroid hormones, Chapter 6 in: The Thyroid Gland, DeVisscher M editor, Raven Press, New York, 1980, pages 123-143.

180. Coleoni AH, DeGroot LJ. Liver nuclear protein phosphorylation in vivo and the effect of triiodothyronine. Endocrinology 106:1103-1107, 1980.

181. Hashizume K, DeGroot LJ. Release of thyrotropin receptor from thyroid plasma membranes: effect of hydrocortisone, propranolol, and adenosine 3’, 5’-monophosphate. Endocrinology 106:1463-1468, 1980.

182. DeGroot LJ, Rue PA. Uptake of T3 receptor complex by liver cell nuclei in vitro. Acta Endocrinol 93:201-207, 1980.

183. Barsano CP, Coleoni AH, DeGroot LJ. Description and partial characterization of thyroid hormone-specific and thyroid hormone-dependent rat liver nuclear proteins. Endocrinology 106:1475-1488, 1980.

184. Carey C, Skosey C, Pinnamaneni KM, Barsano CP, DeGroot LJ. Thyroid abnormalities in children of parents who have Graves’ disease; possible pre-Graves’ disease. Metabolism 29:369-376, 1980.

185. DeGroot LJ, Carey C, Skosey C, Pinnamaneni KM, Mariotti S, Barsano CP. The development of clinical thyrotoxicosis: Pre-Graves’ disease. In: Autoimmune Aspects of Endocrine Disorders, edited by Pinchera A, Doniach D, Fenzi GF, Baschieri L. Academic Press, London, 1980, pages 91-102.

186. Refetoff S, DeGroot LJ, Basano CP. Defective thyroid hormone feedback regulation in the syndrome of peripheral resistance to thyroid hormone. J Clin Endocrinol Metab 51:41-45, 1980.

187. Mariotti S, Oger J-F, Fragu P, Antel JP, Kuo HH, DeGroot LJ. A new solid-phase radioimmunoassay to measure IgG secreted by cultured human lymphocytes. J Immunol Methods 35:189-199, 1980.

188. DeGroot LJ, Rue PA. Effect of triiodothyronine on deoxyribonucleic acid-dependent ribonucleic acid polymerase function in rat liver nuclei. Endocrinology 107:1989-1997, 1980.

189. DeGroot LJ, Rue PA. Mechanism of triiodothyronine stimulation of RNA polymerase in rat liver nuclei. Proceedings of the Eighth International Congress, Sydney, Australia, February 3-8, 1980.

190. Mariotti S, Kaplan EL, Medof ME, DeGroot LJ. Circulating thyroid antigen antibody immune complexes. Proceedings of the Eighth International Thyroid Congress, Sydney, Australia, February 3-8, 1980.

191. DeGroot LJ, Rue PA. Mechanism of thyroid hormone action on the cell nucleus. Proceedings of the Sixth International Congress of Endocrinology, Melbourne, Australia, February 10-16, 1980.

192. Refetoff S, DeGroot LJ, Bernal J. Resistance to the action of thyroid hormone. Proceedings of the Sixth International Congress of Endocrinology, Melbourne, Australia February 10-16, 1980.

193. Nagasaka A, DeGroot LJ, Hidaka H. Binding of Iproniazid to the polymeric forms of iodide peroxidase. Experientia 36:880-881, 1980.

194. Fenzi G, DeGroot LJ. Purification and storage of 125-I TSH. J Nuc Med Allied Sci 25:11, 1981.

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195. Cooper DS, Axelrod L, DeGroot LJ, Vickery Jr AL, Maloof F. Congenital goiter and the development of metastatic follicular carcinoma with evidence for a leak of nonhormonal iodide: clinical, pathological, kinetic, and biochemical studies and a review of the literature. J Clin Endocrinol Metab 52:294-306, 1981.

196. Aoki N, DeGroot LJ. Suppression of PHA-induced lymphocyte blastogenesis by concomitant presence of PPD in the culture. Experientia 37:901-902, 1981.

197. Fenzi G, Mariotti S, Bartalena L, DeGroot LJ. Thyroid stimulating immunoglobulins. In: Special Topics in Endocrinology and Metabolism, Cohen M editor. Alan R. Liss, New York, 1981.

198. Korff JM, DeGroot LJ. The management of radiation-induced tumors of the thyroid. In: Clinics in Endocrinology and Metabolism, Vol. 10, WB Saunders Company Ltd, 1981, pages 299-315.

199. DeGroot LJ, Reilly M. Radiation-associated thyroid neoplasia. In: Advances in Thyroid Neoplasia, edited by Andreoli M, Monaco F, Robbins J. Field Educational Italia, Rome, pages 149-161, 1981.

200. DeGroot LJ. Lymph nodes and recurrence of thyroid cancer. In: Le Ganglion non envahi N-, Proceedings of the Coloquium presented by the Institut Gustave-Roussy, held at Villejuif, France, September 14-16, 1981, pages 183-193.

201. Aoki N, DeGroot LJ. Inhibition of leukocyte migration by human thyroid adenocarcinoma associated antigens. Acta Endocrinol 99:56-63, 1982.

202. Pacini F, Fragu P, Mariotti S, DeGroot LJ. Effect of Indomethacin on phytohemagglutinin-stimulated peripheral blood lymphocytes in thyroid autoimmune diseases. J Clin Immunol 2:335-342, 1982.

203. Yamamoto K, DeGroot LJ. Affinity chromatography of thyroid peroxidase using tyrosine coupled to agarose. J Biochem 91:775-782, 1982.

204. Kuzuya N, DeGroot LJ. Effect of plasmapheresis and steroid treatment on thyrotropin binding inhibitory immunoglobulins in a patient with exophthalmos and a patient with pretibial myxedema. J Endocrinol Invest 5:373-378, 1982.

205. Barsano CP, Skosey C, DeGroot LJ, Refetoff S. Serum thyroglobulin in the management of patients with thyroid cancer. Arch Int Med 142:763-767, 1982.

206. DeGroot LJ, Reilly M. Comparison of 30- and 50-mCi doses of I-131 for thyroid ablation. Ann Int Med 96:51-53, 1982.

207. Franklin WA, Mariotti S, Kaplan D, DeGroot LJ. Immunofluorescnce localization of thyroglobulin in metastatic thyroid cancer. Cancer 50:939-945, 1982.

208. Sridama V, Pacini F, DeGroot LJ. Decreased suppressor T-lymphocytes in autoimmune thyroid diseases detected by monoclonal antibodies. J Clin Endocrinol Metab 54:316-319, 1982.

209. Sridama V, Pacini F, Yang S-L, Moawad A, Reilly M, DeGroot LJ. Decreased levels of helper T cells. A possible cause of immunodeficiency in pregnancy. New Engl J Med 307:352-356, 1982.

210. DeGroot LJ, Nakamura H. Thyroid hormone receptors and action. Tiroides 82—Proceedings of the First Latin American Thyroid Congress, edited by Niepomniszcze H, Pisarev MA. Editorial Medica Panamericana, Buenos Aires, 1982, pages 13-32.

211. Lever EG, DeGroot LJ. Hereditable dyshormonogenetic goiters. In: Diminished Thyroid Hormone Formation. Possible Causes and Clinical Aspects. Proceedings of the Merck International Thyroid Symposium, Hamburg, Germany, November 19-21, 1981. Edited by Reinwein D, Klein E. Schattauer Verlag, Stuttgart, 1982, pages 97-137.

212. DeGroot LJ. Clinical features and management of radiation-associated thyroid carcinoma. In: Surgery of the Thyroid and Parathyroids, edited by Kaplan EL. Churchill Livingstone Inc, New York, 1982, pages 40-50.

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213. Nakamura H, DeGroot LJ. Protein phosphorylation and thyroid hormone action. Proceedings of the International Symposium on Hormone Receptors and Its Diseases, Kyoto, Japan, August 29-30, 1982.

214. Mariotti S, Martino E, DeGroot LJ. Attualita diagnostiche in tema di noduli tiroidei. Recenti Progressi in Medicina 73:190-213, 1982.

215. Pacini F, DeGroot LJ. Studies of immunoglobulin synthesis in cultures of peripheral T and B lymphocytes: reduced T-suppressor cell activity in Graves’ disease. Clin Endocrinol 18:219-232, 1983.

216. Barsano CP, DeGroot LJ. Nuclear-cytoplasmic inter-relationships. In: Molecular Basis of Thyroid Hormone Action, edited by Oppenheimer JH, Samuels HH. Academic Press, New York, 1983, pages 140-178.

217. Nakamura H, DeGroot LJ. Thyroid hormone stimulation of phosphorylation and dephosphorylation of rat liver cytosolic proteins. Endocrinology, 112:670-680, 1983.

218. DeGroot LJ, Rue PA. Pathophysiologic control of nuclear triiodothyronine receptor capacity. Acta Endocrinol., 104:57-63, 1983.

219. DeGroot LJ, Reilly M, Pinnamaneni K, Refetoff S. Retrospective and prospective study of radiation-induced thyroid disease. Am J Med 74:852-862, 1983.

220. Pacini F, Nakamura H, DeGroot LJ. Effect of hypo- and hyperthyroidism on the balance between helper and suppressor T-cells in rats. Acta Endocrinol 103:528-534, 1983.

221. Nakamura H, Rue PA, DeGroot LJ. Thyroid hormone increases Type I adenosine 3’, 5’-monophosphate-dependent protein kinase and casein kinase activities in rat liver cytosol: analysis of protein kinases by polyacrylamide disc gel electrophoresis. Endocrinology, 112:1427-1433, 1983.

222. Pacini F, Sridama V, Pressendo J, DeGroot LJ, Medof ME. Binding of immunoglobulin-G from patients with thyroid autoimmune disease in normal T-lymphocytes. Clin Endocrinol 18:29-37, 1983.

223. Sarne DH, DeGroot LJ. Thyroid carcinoma. Look for a history of irradiation. Consultant 23:233-241, 1983.

224. DeGroot LJ. Laboratory diagnosis of thyroid tumors. Ann Clin Lab Science 13:77, 1983. 225. Lever EG, Medeiros-Neto GA, DeGroot LJ. Inherited disorders of thyroid metabolism.

Endocrine Reviews 4:213-239, 1983. 226. DeGroot LJ, Sridama V. Development of thyroid autoimmunity. In: New Concepts in

Thyroid Disease, edited by Soto RJ, Sartorio G, deFortezai I. Alan R Liss Inc, New York, 1983, pages 1-22.

227. Toffel F, DeGroot LJ. Mechanism of action of thyroid hormone. In: Tiroides. Su Funcion Normal Y Sus Enfermedades, edited by Maisterrena JA. Promociones Azanca SA, Mexico City, 1983, pages 93-114.

228. Sridama V, Yang S-L, Moawad A, DeGroot LJ. T-cell subsets in patients with pre-eclampsia. Amer J Obstet Gyne 147:566-569, 1983.

229. Carey C, DeGroot LJ. Endocrine disease and the heart. In: Friedberg: Diseases of the Heart, 4th edition. Edited by Resnekov L, Julian D. Churchill Livingstone, Edinburgh, 1984.

230. Sridama V, McCormick M, Kaplan EL, Fauchet E, DeGroot LJ. Long-term follow-up study of compensated low dose 131-I therapy for Graves’ disease. New Engl J Med 311:426-432, 1984.

231. DeGroot LJ, Larsen PR, Refetoff S, Stanbury JB (editors), The Thyroid and Its Diseases, 5th edition, John Wiley & Sons, New York, 1984, 907 pages.

232. DeGroot LJ. Post-receptor mechanisms in thyroid hormone action. J Endocrinol Invest 7:15, 1984.

233. DeGroot LJ, Toffel F, Kubica A, Brtko J. Post-receptor mechanisms in thyroid hormone action. Proceedings of the Seventh International Congress of Endocrinology, Quebec,

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Canada, 1984-ICS No. 655. Edited by Labrie F, Proulx L. Elsevier Science Publishers BV, 1984, pages 981-990.

234. DeGroot LJ, Sridama Y, Hara Y, Mori H, Hamada N, Ryan M. Quantitative and qualitative abnormalities in circulating lymphocytes in autoimmune thyroid disease. Proceedings of the International Satellite Symposium on Autoimmunity and the Thyroid. Toronto, Ontario, Canada, June 29, 1984.

235. Nakamura H, DeGroot LJ. CAMP independent casein kinase mediates phosphorylation of many T3-dependent phosphoproteins in rat liver cytosol. Horm Metab Res 16:576-580, 1984.

236. DeGroot LJ, Reilly M. Use of isotope bone scans and skeletal survey X-rays in the follow-up of patients with thyroid cancer. J Endocrinol Invest 7:175-180, 1984.

237. DeGroot LJ, Rue PA, Nakamura H. Alterations in hepatic protein kinase activity induced by triiodothyronine. J Endocrinol Invest 7:429-439, 1984.

238. Sridama V, Hara Y, Fauchet R, DeGroot LJ. Association of differentiated thyroid carcinoma with HLA-DR7. Cancer 56:1086-1088, 1985.

239. Ryan M, Sridama V, DeGroot LJ. Cold-reactive lymphocytotoxic activity in autoimmune thyroid disease. Acta Endocrinol 109:492-498, 1985.

240. DeGroot LJ. Thyroid carcinoma (excluding medullary carcinoma). In: Current Therapy in Endocrinology and Metabolism, 1985-1986. BC Decker Inc, Philadelphia, 1985, pages 89-92.

241. Mori H, Hamada N, DeGroot LJ. Studies on thyroglobulin specific suppressor T cell function in autoimmune thyroid disease. J Clin Endocrinol Metab 61:306-312, 1985.

242. Hamada N, Grimm C, Mori H, DeGroot LJ. Identification of thyroid microsomal antigen by Western Blot and immunoprecipitation. J Clin Endocrinol Metab 61:120-128, 1985.

243. Portmann L, Hamada N, Heinrich G, DeGroot LJ. Antithyroid peroxidase antibody in patients with autoimmune thyroid disease: possible identity with antimicrosomal anatibody. J Clin Endocrinol Metab 61:1001-1003, 1985.

244. Nakamura H, Yokota T, Imura H, DeGroot LJ. Early effect of thyroid hormone on cytosolic protein phosphorylation in rat anterior pituitary. Acta Endocrinol 109:326-329, 1985.

245. DeGroot LJ, Portmann L. Hereditable defects in thyroid peroxidase function. In: Frontiers In Thyroidology, Vol. 1, edited by Medeiros-Neto G, Gaitan E. Plenum Publishing Corp, New York, 1986, pages 83-90.

246. Ichikawa K, DeGroot LJ, Refetoff S, Horwitz AL, Pollak ER. Nuclear thyroid hormone receptors in cultured human fibroblasts. Improved method of isolation, partial characterization, and interaction with chromatin. Metabolism 35:861-868, 1986.

247. Ichikawa K, DeGroot LJ. Separation of DNA-binding domain from hormone and core histone-binding domains by trypsin digestion of rat liver nuclear thyroid hormone receptor. J Biol Chem 261:16540-16546, 1986.

248. Arganini M, Behar R, Wu T-C, Straus F, McCormick M, DeGroot LJ, Kaplan EL. Hurthle cell tumors: A twenty-five year experience. Surgery 100:1108-1115, 1986.

249. Behar R, Arganini M, Wu T-C, McCormick M, Straus FH, DeGroot LJ, Kaplan EL. Graves’ disease and thyroid cancer. Surgery 100:1121-1127, 1986.

250. Brtko J, Knopp J, DeGroot LJ. Physiochemical factors influencing the stability of solubilized liver nuclear receptor-3,5,3’-triiodothyronine complex. Endocrinol Experimentalis 21:251-256, 1987.

251. Ichikawa K, DeGroot LJ. Thyroid hormone receptors in a human hepatoma cell line: multiple receptor forms on isoelectric focusing. Mol Cellul Endocrinol 51:135-143, 1987.

252. Hamada N, Portmann L, DeGroot LJ. Characterization and isolation of thyroid microsomal antigen. J Clin Invest 79:819-825, 1987.

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253. Hamada N, Jaeduck N, Portmann L, Ito K, DeGroot LJ. Antibodies against denatured and reduced thyroid microsomal antigen in autoimmune thyroid disease. J Clin Endocrinol Metab 64:230-238, 1987.

254. Ichikawa K, Hughes IA, Horwitz AL, DeGroot LJ. Characterization of nuclear thyroid hormone receptors of cultured skin fibroblasts from patients with resistance to thyroid hormone. Metabolism 36:392-399, 1987.

255. Ichikawa K, DeGroot LJ. Purification and characterization of rat liver nuclear thyroid hormone receptors. Proc Natl Acad Sci USA 84:3420-3424, 1987.

256. Ichikawa K, Bentley S, Fee M, DeGroot LJ. Modification of deoxyribonucleic acid – thyroid hormone receptor interaction by histones. Endocrinology, 121:893-899, 1987.

257. DeGroot LJ, Portmann L, Hamada N. Progress in understanding the thyroid microsomal antigen. In: Thyroid Autoimmunity-Thirtieth Anniversary: Memories and Perspectives, edited by Pinchera A. Plenum Press, New York, 1987, pages 27-34.

258. Portmann L, Hamada N, Franklin WA, DeGroot LJ. Further characterization of the thyroid microsomal antigen by monoclonal antibodies. In: Thyroid Autoimmunity-Thirtieth Anniversary: Memories and Perspectives, edited by Pinchera A. Plenum Press, New York, 1987, pages 279-281.

259. Ichikawa K, DeGroot LJ. Antibody against nuclear thyroid hormone receptors. Biochem Biophys Res Commun 144:178-184, 1987.

260. Magnusson RP, Chazenbalk GD, Gestautas J, Seto P, Filetti S, DeGroot LJ, Rapoport B. Molecular cloning of the complementary deoxyribonucleic acid for human thyroid peroxidase. Molecul Endocrinol 1:856-861, 1987.

261. Seto P, Hirayu H, Magnusson RP, Gestautas J, Portmann L, DeGroot LJ, Rapoport B. Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase. J Clin Invest 80:1205-1208, 1987.

262. Hara Y, Sridama V, Mori H, DeGroot LJ. Immunoregulatory abnormalities in autoimmune thyroid diseases. Endocrinol Japon 34:203-211, 1987.

263. DeGroot LJ, Ichikawa K. Normal and abnormal human thyroid hormone nuclear receptors. In: Investigation of Thyroid Function: Fundamental and Clinical Aspects. Proceedings of the International Symposium on Thyroid Function Tests, May 9-10, 1985, Ile De Bendor, France. Merck Laboratories, 1987, pages 50-55.

264. Hughes IA, Ichikawa K, DeGroot LJ, John R, Jones MK, Hall R, Scanlon MF. Non-adenomatous inappropriate TSH hypersecretion and euthyroidism requires no treatment. Clin Endocrinol 27:475-483, 1987.

265. Hara Y, Satoh K, Tanikawa T, Sakatsume Y, Ishii J, DeGroot LJ. Spontaneous in vitro production of thyroglobulin specific helper factor in patints with autoimmune thyroid diseases. J Clin Lab Immunol 22:107-112, 1987.

266. Sridama V, Hara Y, Fauchet R, DeGroot LJ. HLA immunogenetic heterogeneity in Black American patients with Graves’ disease. Arch Int Med 147:229-231, 1987.

267. Portmann L, Fitch F, Havran W, Hamada N, Franklin WA, DeGroot LJ. Characterization of the thyroid microsomal antigen, and its relationship to thyroid peroxidase, using monoclonal antibodies. J Clin Invest 81:1217-1224, 1988.

268. DeGroot LJ, Stillabower GM, Ichikawa K, Coleoni A, Darling DD. Binding of thyroid hormone receptor associated factors to rGH gene 5’ flanking sequences. Molec Cellul Endocrinol 57:123-129, 1988.

269. Fisfalen M-E, DeGroot LJ, Quintans J, Franklin WA, Soltani K. Microsomal antigen reactive lymphocyte lines and clones derived from thyroid tissue of patients with Graves’ disease. J Clin Endocrinol Metab 66:776-784, 1988.

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270. Mariotti S, Medof ME, Anelli S, Pinchera A, DeGroot LJ. Comparison of complement fixation and radioassay techniques to detect solubilized human thyroid microsomal antigenic activity. J Endocrinol Invest 11:141-144, 1988.

271. Nakai A, Seino S, Sakurai A, Szilak I, Bell GI, DeGroot LJ. Characterization of a thyroid hormone receptor expressed in human kidney and other tissues. Proc Natl Acad Sci USA 85:2781-2785, 1988.

272. Nakai A, Sakurai A, Bell GI, DeGroot LJ. Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues. Molecul. Endocrinol 2:1087-1092, 1988.

273. DeGroot LJ. (Editor-in-Chief) Endocrinology, Edition Two, WB Saunders Co, Philadelphia, 1988, 2776 pages.

274. Hara Y, Sridama V, DeGroot LJ. Auto-anti-idiotype antibody against antithyroglobulin auto-antibody in humans. J Clin Lab Immunol 26:13-20, 1988.

275. DeGroot LJ. Radiation and thyroid disease. In: Bailliere’s Clinical Endocrinology and Metabolism, Vol. 2, Chapter 14, edited by Lazarus JH, Hall R. Bailliere Tindall/WB Saunders Company, London, pages 777-791, 1988.

276. Hamada N, Okamoto Y, Hinotani A, Yamakawa J, Ohno M, Ito K, DeGroot LJ, Morii H. 101 kDa thyroid microsomal antigen—two forms? In: The Thyroid, 1988, edited by Nagataki S, Torizuka K. Excerpta Medica, Amsterdam, 1988, pages 129-132.

277. Ichikawa K, Hashizume K, Furuta S, Nishii Y, Miyamoto T, Osumi T, Yamauchi K, Otsuka H, Yamada T, DeGroot LJ. Conformational transition of human c-erbA protein upon thyroid hormone binding. In: The Thyroid, 1988, edited by Nagataki S, Torizuka K. Excerpta Medica, Amsterdam, 1988, pages 357-360.

278. Ichikawa K, Brtko J, DeGroot LJ, Hashizume K, Yamada T. Stability of rat liver nuclear thyroid hormone receptor during purification. Exp Clin Endocrinol 7:203-207, 1988.

279. Aguayo J, Michaud P, Iitaka M, DeGroot LJ, Row VV, Volpe R. Lack of effect of methimazole on thyrocyte cell-surface antigen expression. Autoimmunity 2:133-143, 1989.

280. Sakurai A, Nakai A, DeGroot LJ. Expression of three forms of thyroid hormone receptor in human tissues. Molecul Endocrinol 3:392-399, 1989.

281. Sridama V, DeGroot LJ. Treatment of Graves’ disease and the course of ophthalmopathy. Amer J Med 87:70-73, 1989.

282. DeGroot LJ. Causes of thyroid autoimmunity. In: Progress in Thyroidology, 1989, Proceedings of the Fourth Asia and Oceania Thyroid Association Meeting, Seoul, Korea, April 19-21, 1989, edited by Lee M, Koh C-S, Eastman CJ, Nagataki S. Korea Medical Publishing Company, Seoul,l Korea, 1989, pages 1-3.

283. Hamada N, Okamoto Y, Yamakawa J, Ohno M, Noh J, Ito K, Yano T, Shibata M, DeGroot LJ, Morii H. Investigation of antigenic determinants in thyroid microsomal antigen by protein footprinting. In: Progress in Thyroidology, 1989. Proceedings of the Fourth Asia and Oceania Thyroid Association Meeting, Seoul Korea, April 19-21, 1989, edited by Lee M, Koh C-S, Eastman CJ, Nagataki S. Korea Medical Publishing Company, Seoul, Korea, 1989, pages 29-32.

284. Ichikawa K, Brtko J, DeGroot LJ, Hashizume K, Yamada T. Stabilization, accurate determination and purification of rat liver nuclear thyroid hormone receptor. J Endocrinol 120:237-243, 1989.

285. DeGroot LJ. Thyroid hormone nuclear receptors and their role in the metabolic action of the hormone. Biochimie 71:269-277, 1989.

286. DeGroot LJ. Diagnostic approach and management of patients exposed to irradiation to the thyroid. J Clin Endocrinol Metab 69:925-928, 1989.

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287. DeGroot LJ. Abnormal thyroid function tests in euthyroid patients. In: Diagnostic Methods in Clinical Thyroidology, Chapter 1, edited by Hamburger JJ, Springer-Verlag, New York, 1989, pages 3-15.

288. DeGroot LJ, Mangklabruks A. Is it prudent to assume that replacement thyroid hormone therapy should be withheld from patients with severe NTI, low T4, and a grave prognosis? Commentary to Chapter 1 in: Diagnostic Methods in Clinical Thyroidology, edited by Hamburger JJ, Springer-Verlag, New York, 1989, pages 17-22.

289. DeGroot LJ, Jahazi BL. Available data do not indicate that serum TG assay can substitute for whole body 131-I scans. Commentary to Chapter 6 in: Diagnostic Methods in Clinical Thyroidology, edited by Hamburger JJ, Springer-Verlag, New York, 1989, pages 138-142.

290. DeGroot LJ. What controls thyroid growth – that is, thyroid size? In: Control of the Thyroid Gland, edited by Ekholm R, Kohn LD, Wollman SH, Plenum Publishing Corp, New York, pages 5-10, 1989.

291. Sakurai A, Takeda K, Ain K, Ceccarelli P, Nakai A, Seino S, Bell GI, Refetoff S, DeGroot LJ. Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta. Proc Natl Acad Sci USA 86:8977-8981, 1989.

292. DeGroot LJ, Quintans J. The causes of autoimmune thyroid disease. Endocrine Rev 10:537-562, 1989.

293. DeGroot LJ, Nakai A, Sakurai A, Macchia E. The molecular basis of thyroid hormone action. J Endocrinol Invest 12:843-861, 1989.

294. Fisfalen M-E, Franklin WA, DeGroot LJ, Cajulis RS, Soltani K, Ryan M, Jones N. Expression of HLA-ABC and –DR antigens in thyroid neoplasia and correlation with mononuclear leukocyte infiltration. J Endocrinol Invest 13:41-48, 1990.

295. DeGroot LJ, Mangklabruks A, McCormick M. Comparison of RA131I treatment protocols for Graves’ disease. J Endocrinol Invest 13:111-118, 1990.

296. Fisfalen M-E, Soltani K, Janiga AM, Kawakami Y, Macchia E, Quintans J, DeGroot LJ. The regulatory role of human helper T cell clones on antithyroid antibody production by peripheral B cells. J Clin Endocrinol Metab 71:170-178, 1990.

297. Macchia E, Nakai KA, Janiga A, Sakurai A, Fisfalen M-E, Gardner P, Soltani K, DeGroot LJ. Characterization of ‘site specific’ polyclonal antibodies to c-erbA peptides recognizing human thyroid hormone receptors alpha-1, alpha-2, and beta and native T3 receptor and study of tissue distribution of the antigen. Endocrinology 126:3232-3239, 1990.

298. Sakurai A, Nakai A, DeGroot LJ. Structural analysis of human thyroid hormone receptor beta gene. Molecul Cellul Endocrinol 71:83-91, 1990.

299. DeGroot LJ, Kaplan EL, McCormick M, Straus FH. Natural history, treatment, and course of papillary thyroid carcinoma. J Clin Endocrinol Metab 71:414-424, 1990.

300. DeGroot LJ. Heterogeneity of human autoantibodies to TPO. In: Thyroperoxidase and Thyroid Autoimmunity, Vol. 207, edited by Carayon P, Ruf J. John Libbey Eurotext Ltd, Montrouge, France, pages 177-182, 1990.

301. Medeiros-Neto G, Mangklabruks A, Cox NJ, Rosenthal D, Carvalho-Guimaraes DP, DeGroot LJ. Defective expression of the thyroid peroxidase gene. In: Thyroperoxidase and Thyroid Autoimmunity, Vol 207, edited by Carayon P, Ruf J. John Libbey Eurotext Ltd, Montrouge, France, 1990.

302. Nakai A, Sakurai A, Macchia E, Fang V, DeGroot LJ. The roles of three forms of human thyroid hormone receptor in gene regulation. Molec Cellul Endocrinol 72:143-148, 1990.

303. Nakai A, Kartha S, Sakurai A, Toback FG, DeGroot LJ. A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. Molecul Endocrinol 4:1438-1443, 1990.

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304. Sakurai A, Miyamoto T, Refetoff S, DeGroot LJ. Dominant negative transcriptional regulation by a mutant thyroid hormone receptor beta in a family with generalized resistance to thyroid hormone. Molecul Endocrinol 4:1988-1994, 1990.

305. Rentoumis A, Krishna V, Chatterjee K, Madison LD, Datta S, Gallagher GD, DeGroot LJ, Jameson JL. Negative and positive transcriptional regulation by thyroid hormone receptor isoforms. Molecul Endocrinol 4:1522-1531, 1990.

306. DeGroot LJ. Mechanism of thyroid hormone action. In: Proceedings of the International Symposium on Advances in Perinatal Thyroidology, Longboat Key, FL, December 2-4, 1990. Edited by Bercu BB, Plenum Publishing Corp, New York, 1990.

307. Ichikawa K, DeGroot LJ. Receptor purification of the thyroid hormone receptor. Receptor Purification 2:321-335, 1990.

308. Takeda K, Balzano S, Sakurai A, DeGroot LJ, Refetoff S. Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation. J Clin Invest 87:496-502, 1991.

309. Mangklabruks A, Correa Billerbeck A-E, Wajchenberg B, Knobel M, Cox NJ, DeGroot LJ, Medeiros-Neto G. Genetic linkage studies of thyroid peroxidase (TPO) gene in families with TPO deficiency. J Clin Endocrinol Metab 72:471-476, 1991.

310. Mangklabruks A, Cox N, DeGroot LJ. Genetic factors in autoimmune thyroid disease analyzed by restriction fragment length polymorphisms of candidate genes. J Clin Endocrinol Metab 73:236-244, 1991.

311. Curran PG, DeGroot LJ. The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland. Endocrine Reviews 12:135-150, 1991.

312. DeGroot LJ. Substituting L-thyroxine products: Debate continues. Hospital Formulary 26:67-70, 1991.

313. DeGroot LJ, Kaplan EL. Second operations for completion of thyroidectomy in treatment of thyroid cancer. Surgery 110:936-940, 1991.

314. Planells R, Peyrol N, DeGroot LJ, Henry M, Cartouzou G, Torresani J. Production of rat Spot14 protein in Escherichia coli. Gene 99:205-209, 1991.

315. DeGroot LJ, Sakurai A, Miyamoto T, Falcone M. Thyroid hormone receptors and thyroid hormone resistance. In: Proceedings of the Third International Conference on the Use of Human Cells, Tissues, and Organs in Research, Washington, DC. Edited by Torgerson LD, Strickler S, Sheridan W, Lucaccioni B. The National Disease Research Interchange, Philadelphia, 1991, pages 100-101.

316. Miyamoto T, Sakurai A, DeGroot LJ. Effects of zinc and other divalent metals on DNA binding and hormone binding activity of human alpha-1 thyroid hormone receptor expressed in Escherichia coli. Endocrinology 129:3027-3033, 1991.

317. DeGroot LJ. Book Review: Nuclear Hormone Receptors. Edited by Parker MG, Academic Press Ltd, London, 1991, 404 pages. Cancer Cells 3:324-325, 1991.

318. Hamada N, DeGroot LJ, Portmann L, Yamakawa J, Noh J, Okamoto Y, Ohno M, Ito K, Morii H. Thyroid microsomal antigen in Graves’ thyroid is not different from that in normal thyroid. Endocrinol Japon 38:471-478, 1991.

319. Sakurai A, Bell GI, DeGroot LJ. Dinucleotide repeat polymorphism in the human thyroid hormone receptor beta gene (THRB) on chromosome 3. Nucleic Acids Research 19:6661, 1991.

320. Sakurai A, Bell GI, DeGroot LJ. Dinucleotide repeat polymorphism in the human thyroid hormone receptor alpha gene (THRA) on chromosome 17. Human Molecul Genet 1:553, 1992.

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321. Macchia E, DeGroot LJ. Medical management of thyroid nodules. In: Cancer Medicine, Third Edition, edited by Holland JF, Frei E, Bast RC, Kufe DW, Morton DL, Weichselbaum RR, Lea & Febiger, Philadelphia, 1992.

322. Hu R, Beck C, Chang Y-B, DeGroot LJ. HLA Class II genes in Graves’ disease. Autoimmunity 12:103-106, 1992.

323. Hu R, Sakurai A, Miyamoto T, DeGroot LJ. Expression and function of a human thyroid hormone receptor derived DNA-binding domain protein. Molecul Cellul Endocrinol 84:209-217, 1992.

324. Takeda K, Sakurai A, DeGroot LJ, Refetoff S. Recessive inheritance of thyroid hormone resistance caused by complete dletion of the protein-coding region of the thyroid hormone rceptor beta gene. J Clin Endocrinol Metab 74:49-55, 1992.

325. Macchia E, Falcone M, Giorgilli G, Bogazzi F, Antonangeli L, Baccarini S, Fontanini G, Torresani J, DeGroot LJ, Pinchera A. Site-specific anti-c-erbA antibodies recognizing native thyroid hormone receptors: Their use to detect the expression and localization of alpha and beta c-erbA proteins in rat liver. J Receptor Res 12:201-215, 1992.

326. Sakurai A, Miyamoto T, DeGroot LJ. Cloning and characterization of the human thyroid hormone receptor beta-1 gene promoter. Biochem Biophys Res Commun 185:78-84, 1992.

327. DeGroot LJ, Kawakami Y, Fisfalen M-E, Okamoto Y, Yanagawa T. T cell epitopes in TPO and TSH receptor. Proceedings of the International Hashimoto Symposium—80th Anniversary of Hashimoto;s Disease, Fukuoka, Japan, December 2-5, 1992.

328. Yanagawa T, Mangklabruks A, Hu R, DeGroot LJ. HLA and Caucasian patients with autoimmune thyroid disease. Proceedings of the International Satellite Meeting on Thyrotropin Receptor Antibodies, Kyoto, Japan, December 6-7, 1992.

329. Sakurai A, Takeda K, Refetoff S, DeGroot LJ. Mutations in the thyroid hormone receptor gene as a cause of thyroid hormone resistance in man. Proceedings o the International Symposium on Endocrinology Under 35, Rapallo, Italy, Raven Press, 1992.

330. Reohr PB, Mangklabruks A, Janiga AM, DeGroot LJ, Benjasuratwong Y, Soltani K. Pemphigus vulgaris in siblings: HLA-DR4 and HLA-DQw3 and susceptibility to pemphigus. J Amer Acad Dermatol 27:189-193, 1992.

331. Kawakami Y, Fisfalen M-E, DeGroot LJ. Proliferative responses of peripheral blood mononuclear cells from patients with autoimmune thyroid disease to synthetic peptide epitopes of human thyroid peroxidase. Autoimmunity 13:17-26, 1992.

332. Falcone M, Miyamoto T, Fierro-Renoy JF, Macchia E, DeGroot LJ. Anti-peptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform. Endocrinology 131:2419-2429, 1992.

333. DeGroot LJ, Mayor G. Admission screening by thyroid function tests in an acute general care teaching hospital. Amer J Med 93:558-564, 1992.

334. DeGroot LJ. Current diagnostic strategy. J Endocrinol Invest 15:47-48, 1992. 335. Sakurai A, Miyamoto T, Hughes IA, DeGroot LJ. Characterization of a novel mutant

human thyroid hormone receptor beta in a family with hereditary thyroid hormone resistance. Clin Endocrinol 38:29-38, 1993.

336. Yanagawa T, Mangklabruks A, Chang Y-B, Okamoto Y, Fisfalen M-E, Curran PG, DeGroot LJ. Human histocompatibility leukocyte antigen-DQA1*0501 allele associated with genetic susceptibility to Graves’ disease in a Caucasian population. J Clin Endocrinol Metab 76:1569-1574, 1993.

337. Miyamoto T, Suzuki S, DeGroot LJ. High affinity and specificity of dimeric binding of thyroid hormone receptors to DNA and their ligand dependent dissociation. Molecul Endocrinol 7:224-231, 1993.

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338. Martino G, Anastasi J, Feng J, McShan C, DeGroot LJ, Quintans J, Grimaldi LME. The fate of human peripheral blood lymphocytes after transplantation into SCID mice. Eur J Immunol 23:1023-1028, 1993.

339. Riccabona G, DeGroot LJ, Delange F, Dunn JT, Galvan G, Piyasena RD, Reinwein D, Roher H, Rosler H, Schlumberger M, Stanbury JB, Vitti P, Williams D. Clinical thyroidology: what do we really need? J Endocrinol Invest 16:297-302, 1993.

340. DeGroot LJ. Review of book: Report on Myxedema, 1988. Trends in Endocrinol Metab 4:29, 1993.

341. DeGroot LJ. TRAPS—Thyroid Receptor Auxiliary Proteins. (Editorial) Endocrinology 133:963-964, 1993.

342. DeGroot LJ. Effects of irradiation on the thyroid gland. Chapter in Endocrinology and Metabolism. Clinics of North America, Vol. 22, edited by Rosenfield RL, WB Saunders Co, Philadelphia, 1993, pages 607-615.

343. DeGroot LJ, Fierro-Renoy JF, Falcone M, Suzuki S, Miyamoto T. Receptores nucleares de hormonas tiroideas: en la interfase de la biologia molecular y la medicina clinica. Revista Endocrinologia 40:118-122, 1993.

344. Sakurai A, Takeda K, Refetoff S, DeGroot LJ. Mutations in the thyroid hormone receptor gene as a cause of thyroid hormone resistance in man. In: New Perspectives in Endocrinology, Serono Symposia Publications, Vol. 99, edited by DeBellis A, Marschke KB, Raven Press, New York, 1993, pages 169-180.

345. Curran PG, DeGroot LJ. Radiation-associated thyroid neoplasms. In: Endocrine Tumors, Chapter 20, edited by Mazzaferri EL, Samaan NA, Blackwell Scientific Publications Inc, Oxford, England, 1993, pages 254-277.

346. Suzuki S, Miyamoto T, Opsahl A, Sakurai A, DeGroot LJ. Two thyroid hormone response elements are present in the promoter of human thyroid hormone receptor β1. Molecul Endocrinol 8:305-314, 1994.

347. Meier CA, Braverman LE, Ebner SA, Veronikis I, Daniels GH, Ross DS, Deraska DJ, Davies TF, Valentine M, DeGroot LJ, Curran P, McEllin K, Reynolds J, Robbins J, Weintraub BD. Diagnostic use of recombinant human thyrotropin in patients with thyroid carcinoma (Phase I/II Study). J Clin Endocrinol Metab 78:188-196, 1994.

348. DeGroot LJ, Kaplan EL, Straus FH, Shukla MS. Does the method of management of papillary thyroid carcinoma make a difference in outcome? World J Surg 18:123-130, 1994.

349. Fierro-Renoy JF, DeGroot LJ. Radiation-associated thyroid carcinoma. In: Diseases of The Thyroid, Pathophysiology and Management, edited by Wheeler MH, Lazarus JH, Chapman & Hall Ltd, London, 1994, pages 325-341.

350. DeGroot LJ. Thyroid physiology and hypothyroidism, Chapter 15. In: Clinical Endocrinology – Second Edition, edited by Besser GM, Thorner MO, Mosby Year Book Europe Ltd, London, 1994.

351. Falcone M, Miyamoto T, Fierro-Renoy JF, Macchia E, DeGroot LJ. Evaluation of the ontogeny of thyroid hormone receptor isotypes in rat brain and liver using an immunohistochemical technique. Europ J Endocrinol 130:97-106, 1994.

352. Okamoto Y, Yanagawa T, Fisfalen M-E, DeGroot LJ. Proliferative responses of peripheral blood mononuclear cells from patients with Graves’ disease to synthetic peptide epitopes of human thyrotropin receptor. Thyroid 4:37-42, 1994.

353. DeGroot LJ, Editor-in-Chief, Endocrinology, Third Edition, W B Saunders Co, Philadelphia, 1994.

354. DeGroot LJ. Decision tree analysis of common thyroid problems. Thyroid International, edited by Hennemann G, Krenning E, Merck Pharmaceuticals, Darmstadt, Germany, 12994, pages 1-16.

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355. Curran PG, DeGroot LJ. Thyroid noplasia. In: Current Therapy in Endocrinology and Metabolism, Mosby-Year Book, 1994.

356. Yanagawa T, Mangklabruks A, DeGroot LJ. Strong association between HLA-DQA1*0501 and Graves’ disease in a male Caucasian population. J Clin Endocrinol Metab 79:227-229, 1994.

357. Beck-Peccoz P, Chatterjee VKK, Chin WW, DeGroot LJ, Jameson JL, Nakamura H, Refetoff S, Usala SJ, Weintraub BD. Nomenclature of thyroid hormone receptor β-gene mutations in resistance to thyroid hormone: Consensus statement from the First Workshop on Thyroid Hormone Resistance, Cambridge, England. J Clin Endocrinol Metab 78:990-993, 1994 / Thyroid 4:135-137, 1994 / Europ J Endocrinol 130:426-428, 1994 / J Endocrinol Invest 17:283-287, 1994 / Clin Endocrinol 40:697-700, 1994.

358. Miyamoto T, Suzuki S, DeGroot LJ. Differential binding and activation of thyroid hormone response elements by TRα1 and RXRα-TRAP heterodimers. Molecul Cellul Endocrinol 102:111-117, 1994.

359. Ozata M, Suzuki S, Miyamoto T, Liu R-T, Fierro-Renoy JF, DeGroot LJ. Serum thyroglobulin in the follow-up of patients with treated differentiated thyroid cancer. J Clin Endocrinol Metab 79:98-105, 1994.

360. DeGroot LJ. Long-term impact of initial and surgical therapy on papillary and follicular thyroid cancer. Amer J Med 97:499-500, 1994.

361. Soliman M, Kaplan E, Fisfalen M-E, Okamoto Y, DeGroot LJ. T cell reactivity to recombinant human thyrotropin receptor extracellular domain and thyroglobulin in patients with autoimmune and non-autoimmune thyroid diseases. J Clin Endocrinol Metab 80:206-213, 1995.

362. Soliman M, Kaplan EL, Yanagawa T, Hidaka Y, Fisfalen M-E, DeGroot LJ. T-cells recognize multiple epitopes in the human thyrotropin receptor extracellular domain. J Clin Endocrinol Metab 80:905-914, 1995.

363. Okamoto Y, Hayashi Y, DeGroot LJ. Expression of human thyrotropin receptor by recombinant adenovirus. Thyroid 5:51-53, 1995.

364. Liu R-T, Suzuki S, Miyamoto T, Takeda T, Ozata M, DeGroot LJ. The dominant negative effect of thyroid hormone receptor splicing variang α2 does not require binding to a thyroid response element. Molecul Endocrinol 9:86-95, 1995.

365. Sakurai A, Suzuki S, Katai M, Miyamoto T, Kobayashi H, Nakajima K, Ichikawa K, DeGroot LJ, Hashizume K. Transcriptional regulation of human thyroid hormone receptor β1 gene expression: Effect of human retinoid X receptor and identification of a transcriptional silencer region. Molecul Cellul Endocrinol 110:103-112, 1995.

366. Yanagawa T, Hidaka Y, Guimaraes V, Soliman M, DeGroot LJ. CTLA-4 gene polymorphism associated with Graves’ disease in a Caucasian population. J Clin Endocrinol Metab 80:41-45, 1995.

367. Fisfalen M-E, Soliman M, Okamoto Y, Soltani K, DeGroot LJ. Proliferative responses of T cells to thyroid antigens and synthetic TPO peptides in autoimmune thyroid disease. J Clin Endocrinol Metab 80:1597-1604, 1995.

368. Hidaka Y, Guimaraes V, Soliman M, Yanagawa T, Okamoto Y, Quintans J, DeGroot LJ. Production of thyroid stimulating antibodies in mice by immunization with T cell epitopes of human TSH receptor. Endocrinology 136:1642-1647, 1995.

369. DeGroot LJ, Gorman CA, Pinchera A, Bartalena L, Marocci C, Wiersinga WM, Prummel MF, Wartofsky L. Radiation and Graves’ ophthalmopathy. J Clin Endocrinol Metab 80:339-349, 1995.

370. Fisfalen M-E, DeGroot LJ. Autoimmune thyroid disease II. Graves’ disease and autoimmune thyroiditis. In: Molecular Endocrinology: Basic Concepts and Clinical Correlations, edited by Weintraub, B, Raven Press, New York, 1995, pages 319-370.

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371. Takeda T, Suzuki S, Liu R-T, DeGroot LJ. Triiodothyroacetic acid has unique potential for therapy of resistance to thyroid hormone. J Clin Endocrinol Metab 80:2033-2040, 1995.

372. Fierro-Renoy JF, Szuchet S, Falcone M, Macchia E, DeGroot LJ. Three different thyroid hormone receptor isoforms are detected in a pure culture of ovine oligodendrocytes. GLIA, 14:322-328, 1995.

373. Soliman M, Kaplan EL, Abdel-Latif A, Scherberg N, DeGroot LJ. Does thyroidectomy, RAI therapy, or antithyroid drug treatment alter reactivity of patients’ T cells to epitopes of thyrotropin receptor in autoimmune thyroid diseases? J Clin Endocrinol Metab 80:2312-2321, 1995.

374. Guimaraes V, Quintans J, Fisfalen M-E, Straus FH, Wilhelm K, Medeiros-Neto G, DeGroot LJ. Suppression of development of experimental autoimmune thyroiditis by oral administration of thyroglobulin. Endocrinology, 136:3353-3359, 1995.

375. Soliman M, Kaplan EL, Straus F, Fisfalen M-E, Hidaka Y, Guimaraes V, DeGroot LJ. Graves’ disease in severe combined immunodeficient mice. J Clin Endocrinol Metab 80:2848-2855, 1995.

376. DeGroot LJ, Kaplan EL, Shukla MS, Salti G, Straus FH. Morbidity and mortality in follicular thyroid cancer. J Clin Endocrinol Metab 80:2946-2953, 1995.

377. Ozata M, Suzuki S, Takeda T, Malkin DG, Miyamoto T, Liu R-T, Suzuki N, Silverberg JDH, Daneman D, DeGroot LJ. Functional analysis of a proline to serine mutation in Codon 453 of the thyroid hormone receptor β1 gene. J Clin Endocrinol Metab 80:3239-3245, 1995.

378. Suzuki S, Takeda T, Liu-RT, Hashizume K, DeGroot LJ. Importance of the most proximal GC box for activity of the promoter of human thyroid hormone receptor β1. Molecul Endocrinol 9:1288-1296, 1995.

379. Yanagawa T, Ito K, Kaplan EL, Ishikawa N, DeGroot LJ. Absence of association between human spumaretrovirus and Graves’ disease. Thyroid 5:379-382, 1995.

380. Fierro-Renoy JF, DeGroot LJ. Thyroid masses. Chapter 4 in Current Practice of Medicine, edited by Sapira JD, Alpert JS, Bone RC, Korenman SG. Churchill Livingstone, Inc., NY, pages IV:4.1-IV:4.9, 1996.

381. Hidaka Y, Hayashi Y, Fisfalen, M-E, Suzuki S, Takeda T, Refetoff S, DeGroot LJ. Expression of thyroid peroxidase in EBV-transformed B cell lines using adenovirus. Thyroid 6:23-28, 1996.

382. Yanagawa T, DeGroot LJ. HLA-Class II associations in African-American female patients with Graves’ disease. Thyroid 6:37-39, 1996.

383. DeGroot LJ. Interchangeability of levothyroxine preparations. Amer J Med 100:244-245, 1996.

384. Guimaraes V, DeGroot LJ. Moderate hypothyroidism in preparation for whole body 131-I scintiscans and thyroglobulin testing. Thyroid 6:69-73, 1996.

385. Liu R-T, Suzuki S, Takeda T, DeGroot LJ. An artificial thyroid hormone receptor mutant without DNA binding can have a dominant negative effect. Molecul Cellul Endocrinol 120:85-93, 1996.

386. Manowitz NR, Mayor GH, Klepper MJ, DeGroot LJ. Subclinical hypothyroidism and euthyroid sick syndrome in patients with moderate-to-severe congestive heart failure. Amer J Therap 3:797-801, 1996.

387. Guimaraes V, Quintans J, Fisfalen M-E, Fields PE, Medeiros-Neto G, DeGroot LJ. Immunosuppression of thyroiditis. Endocrinology 137:2199-2207, 1996.

388. DeGroot LJ, Benjasuratwong Y. Evaluation of thyroid ablative therapy for ophthalmopathy of Graves’ disease. Orbit 15:187-196, 1996.

389. DeGroot LJ, Larsen PR, Hennemann G. The Thyroid and Its Diseases, Sixth Edition, Churchill Livingstone, Inc, New York, 1996, 793 pages.

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390. Longstreth WT, Manowitz NR, DeGroot LJ, Siscovick DS, Mayor GH, Copass MK, Weinmann S, Cobb LA. Plasma thyroid hormone profiles immediately following out-of-hospital cardiac arrest. Thyroid 6:649-653, 1996.

391. Soliman M, Kaplan E, Abdel-Latif A, Guimaraes V, Yanagawa T, DeGroot LJ. T cell recognition of residue 158-176 in thyrotropin receptor confers risk for development of thyroid autoimmunity in siblings in a family with Graves’ disease. Thyroid 6:545-551, 1996.

392. DeGroot LJ. Novel actions of thyroid hormone. Editorial as Introduction to the Proceedings of the Satellite Symposium on “Novel Actions of Thyroid Hormone”, Toronto, Ontario, Canada, September 10, 1995. Thyroid 6:379, 1996.

393. Nagasawa T, Suzuki S, Takeda T, DeGroot LJ. Thyroid hormone receptor β1 expression in developing mouse limbs and face. Endocrinology 138:1276-1281, 1997.

394. Zhang R, Scherberg N, DeGroot LJ. Monoclonal antibodies to rat calcitonin: Their use in antigenic mapping and immunohistochemistry. Endocrinology 138:1691-1696, 1997.

395. Zhang R, DeGroot LJ. A monoclonal antibody against rat calcitonin inhibits the growth of a rat medullary thyroid carcinoma cell line in vitro. Endocrinology 138:1697-1703, 1997.

396. Takeda T, Nagasawa T, Miyamoto T, Hashizume K, DeGroot LJ. The function of retinoid X receptors on negative thyroid hormone response elements. Molecul Cellul Endocrinol 128:85-96, 1997.

397. Nagasawa T, Takeda T, Minemura K, DeGroot LJ. Oct-1, silencer sequence, and GC box regulate thyroid hormone receptor beta-1 promoter. Molecul Cellul Endocrinol 130:153-165, 1997.

398. DeGroot LJ. Paul Starr Award to Geraldo Medeiros-Neto, MD. Thyroid 7:157-158, 1997. 399. White DM, Takeda T, DeGroot LJ, Stefansson K, Arnason BGW. β-Trace gene

expression is regulated by a core promoter and a distal thyroid hormone response element. J Biol Chem 272:14387-14393, 1997.

400. Ladenson PW, Braverman LE, Mazzaferri EL, Brucker-Davis F, Cooper DS, Garber JR, Wondisford FE, Davies TF, DeGroot LJ, Daniels GH, Ross DS, Weintraub BD. Comparison of administration of recombinant human thyrotropin with withdrawal of thyroid hormone for radioactive iodine scanning in patients with thyroid carcinoma. New Engl J Med 337:888-896, 1997.

401. Fisfalen M-E, Palmer EM, van Seventer GA, Soltani K, Sawai Y, Kaplan E, Hidaka Y, Ober C, DeGroot LJ. TSH-R and TPO specific T cell clones and their cytokine profile in autoimmune thyroid disease. J Clin Endocrinol Metab 82:3655-3663, 1997.

402. Fisfalen ME, Soltani K, Kaplan E, Palmer EM, van Seventer GA, Straus FH, Diaz M, Ober C, DeGroot LJ. Evaluating the role of ThO and Th1 clones in autoimmune thyroid disease by use of Hu-SCID chimeras. Clin Immunol Immunopathol 85:253-264, 1997.

403. DeGroot LJ. Radioiodine and the immune system. Thyroid 7:259-264, 1997. 404. Fierro-Renoy JF, Falcone M, Macchia E, DeGroot LJ. Deteccion de isoformas del

receptor nuclear de hormonas tiroideas en tejidos humanos: evidencia de un nivel de expresion diferente de la forma alfa y beta-1. Endocrinologia Bolivariana 6:7-13, 1997.

405. Zhang R, Minemura K, DeGroot LJ. Immunotherapy for medullary thyroid carcinoma by a replication-defective adenovirus transducing murine Interleukin-2. Endocrinology 139:601-608, 1998.

406. Lee S, Scherberg N, DeGroot LJ. Induction of oral tolerance in human autoimmune thyroid disease. Thyroid 8:229-234, 1998.

407. Bajramovic S, DeGroot LJ. Spurious metastasis on whole body scans in a patient with thyroid carcinoma. J Endocrinol Invest 21:541-543, 1998.

408. Davies TF, Roti E, Braverman LE, DeGroot LJ. Thyroid controversy—stimulating antibodies. J Clin Endocrinol Metab 83:3777-3784, 1998.

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409. Pacini F, DeGroot LJ. Thyroid Carcinoma. Chapter in: Clinical Endocrinology—Second Edition. Blackwell Science, Ltd., Oxford, UK, 1998.

410. Zhang R, Baunoch D, DeGroot LJ. Genetic immunotherapy for medullary thyroid carcinoma: Destruction of tumors in mice by in vivo delivery of adenoviral vector transducing the murine interleukin-2 gene. Thyroid 8:1137-1146, 1998.

411. DeGroot LJ. Dangerous dogmas in medicine—the nonthyroidal illness syndrome. J Clin Endocrinol Metab 84:151-164, 1999.

412. Zhang R, Straus FH, DeGroot LJ. Effective genetic therapy of established medullary thyroid carcinomas with murine interleukin-2: Dissemination and cytotoxicity studies in a rat tumor model. Endocrinology 140:2152-2158, 1999.

413. Takeda T, Suzuki S, Nagasawa T, Liu R-T, DeGroot LJ. DNA binding affinity of hTRβ1 mutants as heterodimers with TRAPS from different tissues. Biochimie 81:297-308, 1999.

414. Haugen BR, Pacini F, Reiners C, Schlumberger M, Ladenson PW, Sherman SI, Cooper DS, Graham KE, Braverman LE, Skarulis MC, Davies TF, DeGroot LJ, Mazzaferri EL, Daniels GH, Ross DS, Luster M, Samuels MH, Becker DV, Maxon HR, Cavalieri RR, Spencer CA, McEllin K, Weintraub BD, Ridgway EC. A comparison of recombinant human thyrotropin and thyroid hormone withdrawal for the detection of thyroid remnant or cancer. J Clin Endocrinol Metab 84:3877-3885, 1999.

415. Takeda T, Nagasawa T, Miyamoto T, Minemura K, Hashizume K, DeGroot LJ. Quantitative analysis of DNA binding affinity and dimerization properties of wild-type and mutant thyroid hormone receptor β1. Thyroid 10:11-18, 2000.

416. Sawai Y, DeGroot LJ. Binding of human thyrotropin receptor peptides to a Graves’ disease-predisposing human leukocyte antigen Class II molecule. J Clin Endocrinol Metab 85:1176-1179, 2000.

417. DeGroot LJ. Endocrinology in the new millennium. Published on the MEDSCAPE Website: www.medscape.com, in January of 2000.

418. Zhang R, DeGroot LJ. Gene therapy of established medullary thyroid carcinoma with Herpes Simplex viral thymidine kinase in a rat tumor model: relationship by bystander effect and antitumor efficacy. Thyroid 10:313-319, 2000.

419. Zhang R, DeGroot LJ. Genetic immunotherapy of established tumors with adenoviral vectors transducing murine interleukin-12 subunits in a rat medullary thyroid carcinoma model. Clin Endocrinol 52:687-694, 2000.

420. Minemura K, Takeda T, Minemura K, Nagasawa T, Zhang R, Leopardi R, DeGroot LJ. Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of Herpes Simplex virus thymidine kinase. Endocrinology 141:1814-1822, 2000.

421. Kouki T, Sawai Y, Gardine C, Fisfalen M-E, Alegre M-L, DeGroot LJ. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves’ disease. J Immunol 165:6606-6611, 2000.

422. DeGroot LJ, Jameson JL. Co-editors of Endocrinology, Fourth Edition, WB Saunders Co, Philadelphia, 2000, 2,621 pages.

423. Clarke BL, DeGroot LJ. Thyroid hormone regulation of islet cell hormone metabolic actions. Chapter 29 in Handbook of Physiology, The Endocrine System, Volume II, edited by Jefferson LS, Cherrington AD. Oxford University Press, New York, NY, 2000.

424. Zhang R, Straus FH, DeGroot LJ. Adenoviral-mediated gene therapy for thyroid carcinoma using thymidine kinase controlled by thyroglobulin promoter demonstrates high specificity and low toxicity. Thyroid, 11:115-123, 2001.

425. Zhang R, DeGroot LJ. An adenoviral vector expressing functional heterogeneous proteins – Herpes Simplex viral thymidine kinase and human Interleukin-2 has enhanced in

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vivo antitumor activity against medullary thyroid carcinoma. Endocrine-Related Cancer, 8:315-325, 2001.

426. DeGroot LJ, Zhang R. Gene therapy for thyroid cancer—where do we stand? J Clin Endocrinol Metab, 86:2923-2928, 2001.

427. DeGroot LJ. Treatment of multinodular goiter by surgery. J Endocrinol Invest, 24:820-822, 2001.

428. Gardine CA, Kouki T, DeGroot LJ. Characterization of the T lymphocyte subsets and lymphoid populations involved in the induction of low dose oral tolerance to human thyroglobulin. Cellul Immunol, 212:1-15, 2001.

429. DeGroot LJ. Endocrinology 2000-2100: Some thoughts on our future. J Pediat Endocrinol Metab, 14:1387-1392, 2001.

430. Kouki T, Gardine CA, Yanagawa T, DeGroot LJ. Relation of three polymorphisms of the CTLA-4 gene in patients with Graves’ disease. J Endocrinol Invest, 25:208-213, 2002.

431. Zhang R, Straus FH, DeGroot LJ. Cell specific viral gene therapy of a Hurthle cell tumor. J Clin Endocrinol Metab, 87:1407-1414, 2002.

432. Yamazaki M, Zhang R, Straus FH, Messina M, Robinson BG, Hashizume K, DeGroot LJ. Effective gene therapy for medullary thyroid carcinoma using recombinant adenovirus inducing tumor-specific expression of Interleukin-12. Gene Therapy, 9:64-74, 2002.

433. Yanagawa T, Kouki T, DeGroot LJ. CTLA-4 gene in the pathogenesis of Graves’ disease. Chapter in The Genetics of Complex Thyroid Diseases, Akamizu T, Kasuga M, and Davies TF (eds), Springer-Verlag Tokyo, pp 103-107, 2002.

434. DeGroot LJ. Radioactive iodide therapy for Graves’ disease. Chapter 18 in Thyroid Eye Disease: Diagnosis and Treatment. Dutton JJ and Haik BG (eds), Marcel Dekker Inc., New York, pp 171-184, 2002.

435. Takeda T, Yamazaki M, Minemura K, Imai Y, Inaba H, Suzuki S, Miyamoto T, Ichikawa K, Kakizawa T, Mori J-I, DeGroot LJ, Hashizume K. A tandemly repeated thyroglobulin core promoter has potential to enhance efficacy for tissue-specific gene therapy for thyroid carcinomas. Cancer Gene Therapy, 9:864-874, 2002.

436. Medeiros-Neto G, DeGroot LJ. Disorders of thyroid hormone synthesis. Chapter 27 in Genetics in Endocrinology, edited by Baxter J, Melmed S, and New M, Lippincott-Raven Publishers, Philadelphia, 2002.

437. Gardine CA, Gentile F, Pellegrini C, Giallauria F, Torelli G, Kouki T, DeGroot LJ. Multiple fragments of human thyroglobulin are capable of inducing oral tolerance to whole human thyroglobulin. J Endocrinol Invest 26:294-300, 2003.

438. Zhang R, DeGroot LJ. Gene therapy of a rat follicular thyroid carcinoma model with adenoviral vectors transducing murine interleukin-12. Endocrinology 144:1393-1398, 2003.

439. Kon YC, DeGroot LJ. Painful Hashimoto’s thyroiditis as an indication for thyroidectomy: clinical characteristics and outcome in seven patients. J Clin Endocrinol Metab, 88:2667-2672, 2003.

440. Takeda, T, Inaba H, Yamazaki M, Kyo S, Miyamoto T, Suzuki S, Ehara T, Kakizawa T, Hara M, DeGroot LJ, Hashizume K. Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter. J Clin Endocrinol Metab 88:3531-3538, 2003.

441. Takara M, Kouki T, DeGroot LJ. CTLA-4 AT-repeat polymorphism reduces the inhibitory function of CTLA-4 in Graves’ disease. Thyroid, 13:1083-1089, 2003.

442. DeGroot LJ. Nonthyroidal illness syndrome is functional central hypothyroidism, and if severe, hormone replacement is appropriate in light of present knowledge. J Endocrinol Invest 26:1163-1170, 2003.

443. Yamazaki M, Straus FH, Messina M, Robinson BG, Takeda T, Hashizume K, DeGroot LJ. Adenovirus-mediated tumor-specific combined gene therapy using Herpes simplex virus

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thymidine/ganciclovir system and murine interleukin-12 induces antitumor activity against medullary thyroid carcinoma. Cancer Gene Therapy, 11:8-15, 2004.

444. DeGroot LJ, Zhang R. Viral mediated gene therapy for the management of metastatic thyroid carcinoma. In: Current Drug Targets, Smallridge RC, editor, Bentham Science Publishers, 2004, pages 235-244.

445. WWW.THYROIDMANAGER.ORG, web-based textbook, Leslie J De Groot, MD, editor, published by ENDOCRINE EDUCATION, INC. South Dartmouth, MA (c/o ldegroot@earthlink.net)

446. WWW.ENDOTEXT.ORG, web-based textbook, Leslie J De Groot, MD, editor, published by MDTEXT.ORG, INC. South Dartmouth, MA (c/o ldegroot@earthlink.net)

447 . De Groot, LJ , Jameson,l Editors ENDOCRINOLOGY ,5th Edition, published by Elsevier, Philadelphia, PA, Aug 2005. Three volumes, 3000 pages.

448 Pacini, F and De Groot LJ Management of Thyroid Nodules and Thyroid Carcinoma in ENDOCRINOLOGY , 5th Edition, Elsevier, Phildadelphisa , PA, August 2005

449 Fisfalen ME, Schulze TG, DePaulo JR Jr, DeGroot LJ, Badner JA, McMahon FJ. Familial variation in episode frequency in bipolar affective disorder.Am J Psychiatry. 2005 Jul;162(7):1266-72.

450.. De Groot, LJ Non-Thyroidal Illness Syndrome is a Manifestation of Hypothalamic-pituitary Dysfunction, and in View of Current Evidence, Should be Treated with Appropriate Replacement Therapies. Crital Care Clinics 22:57-86, 2006.

451. Inaba H, Martin W, De Groot AS, Qin S, De Groot LJ. Thyrotropin receptor epitopes and their relation to histocompatibility leukocyte antigen-DR molecules in Graves' disease. J Clin Endocrinol Metab. 2006 Jun;91(6):2286-94