SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

PROGRAMME : M. TECHMEDICAL INSTRUMENTATION

CURRICULUMSEMESTER - 1

Sl. No. COURSE CODE COURSE TITLE L T P C PAGE No.

1. SMT5104 Advanced Mathematics 3 1 0 4 2

2. SBM5101 Introduction to Anatomy and Physiology 3 1 0 4 20

3. SBM5102 Biosensing Technologies 3 1 0 4 21

4. SBM5103 Advanced Biomedical Instrumentation 3 1 0 4 22

5. SBM5104 Advanced Medical Image Processing 3 1 0 4 23

6. SBM5105 Computer Based Medical Instrumentation 3 1 0 4 24

PRACTICAL

7. SBM6531 Biomedical Instrumentation Lab 0 0 6 3 67

TOTAL CREDITS: 27

SEMESTER - 2

Sl. No. COURSE CODE COURSE TITLE L T P C PAGE No.

1. SEC5120 Embedded System Design 3 1 0 4 25

2. SBM5106 Biosignal Processing 3 1 0 4 3

3. Elective I 3 1 0 4

4. Elective II 3 1 0 4

5. Elective III 3 1 0 4

6. S44PT Professional Training 0 0 10 5

PRACTICAL

7. SEC6540 Embedded Systems and Circuits Lab 0 0 6 3 63

TOTAL CREDITS: 28

SEMESTER - 3

Sl. No. COURSE CODE COURSE TITLE L T P C PAGE No.

1. SBM5201 Advanced Rehabilitation Engineering 3 1 0 4 26

2. Elective IV 3 1 0 4

3. Elective V 3 1 0 4

4. Elective VI 3 1 0 4

5. Project Work - Phase I

L - LECTURE HOURS, T – TUTORIAL HOURS, P – PRACTICAL HOURS, C – CREDITS

M.E. / M.Tech REGULAR xv REGULATIONS 2015

SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

PRACTICAL

6. SBM6532 Advanced Medical Signal & Image Processing Lab 0 0 6 3 67

TOTAL CREDITS: 19

SEMESTER- IV

Sl. No. COURSE CODE COURSE TITLE L T P C PAGE No.

7. S44PROJ Project Work – Phase I and II 0 0 40 20

TOTAL CREDITS: 20

TOTAL CREDITSFOR THE COURSE: 94

LIST OF ELECTIVES

Sl. No. COURSE CODE COURSE TITLE L T P C PAGE No.

1. SEC5669 Digital Signal Processor 3 1 0 4 76

2. SIC5617 Robotics & Artificial Intelligence 3 1 0 4 77

3. SBM5601 Physiological Control Systems 3 1 0 4 96

4. SBM5602 Mems in Healthcare 3 1 0 4 97

5. SBM5603 Computers in Medicine 3 1 0 4 98

6. SBM5604 Medical Imaging Techniques & Systems 3 1 0 4 99

7. SBM5605 Biomaterials and Artificial Organs 3 1 0 4 100

8. SBM5606 Pattern Recognition and Applications 3 1 0 4 101

9. SBM5607 Hospital Health Systems and Management 3 1 0 4 102

10. SBM5608 Hospital Equipment Maintenance & Safety 3 1 0 4 103

11. SBM5609 Fibre Optics and Laser for Biomedical Applications 3 1 0 4 104

12. SBM5610 Medical Electronics and E-Health 3 1 0 4 105

13. SBM5611 Neural Networks and Fuzzy Logic in Medicine 3 1 0 4 106

M.E. / M.Tech REGULAR xvi REGULATIONS 2015

SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 2 REGULATIONS 2015

SMT5104 ADVANCED MATHEMATICS

(Common to all M.E Branches and M.Tech Bio-Medical,Chemical)

L T P Credits Total Marks

3 1 0 4 100

UNIT 1 MATRIX THEORY 11 Hrs. QR decomposition – Eigen values using shifted QR algorithm- Singular Value Decomposition - Pseudo inverse- Least square approximations

UNIT 2 CALCULUS OF VARIATIONS 13 Hrs. Concept of Functionals - Euler’s equation – functional dependent on first and higher order derivatives – Functionals on several dependent variables – Iso perimetric problems - Variational problems with moving boundaries

UNIT 3 TRANSFORM METHODS 12 Hrs. Laplace transform methods for one dimensional wave equation – Displacements in a string – Longitudinal vibration of a elastic bar – Fourier transform methods for one dimensional heat conduction problems in infinite and semi infinite rod. Laplace equation – Properties of harmonic functions – Fourier transform methods for laplace equations. Solution for Poisson equation by Fourier transforms method

UNIT 4 ELLIPTIC EQUATIONS 11 Hrs. Laplace equation – Properties of harmonic functions – Fourier transform methods for Laplace equations – Solution for Poisson equation by Fourier transforms method.

UNIT 5 LINEAR AND NON-LINEAR PROGRAMMING 13 Hrs. Simplex Algorithm - Two Phase and Big M techniques – Duality theory - Dual Simplex method. Non Linear Programming – Constrained extremal problems - Lagranges multiplier method - Kuhn - Tucker conditions and solutions.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Richard Bronson, Schaum’s Outlines of Theory and Problems of Matrix Operations, McGraw-Hill, 1988. 2. Venkataraman M K, Higher Engineering Mathematics, National Pub. Co, 1992. 3. Elsgolts, L., Differential Equations and Calculus of Variations. Mir, 1977. 4. Sneddon,I.N., Elements of Partial differential equations, Dover Publications, 2006. 5. Sankara Rao, K., Introduction to partial differential equations. Prentice – Hall of India, 1995 6. Taha H A, “Operations research - An introduction, McMilan Publishing co, 1982.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 20 REGULATIONS 2015

SBM5101 INTRODUCTION TO ANATOMY AND

PHYSIOLOGY L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE To enable the student develop a vocabulary of appropriate medical terminology and to help the student learn to

identify and describe the microscopic and macroscopic anatomy of the structures involved in the above body systems. To also describe the various tools used in health care and how they are used in the diagnosis and cure of pathological conditions and to demonstrate an understanding of the relationship between anatomy and physiology by using anatomical knowledge to predict physiological consequences.

UNIT 1 CARDIOVASCULAR AND SPECIAL SENSES 12 Hrs. Structure of Heart, Cardiac Cycle, ECG, Arterial Blood Pressure, Structure of Eye and Ear, Photochemistry of vision and accomodation, Mechanism of Hearing, Sensation of Taste and Sensation of Smell.

UNIT 2 GASTROINTESTINAL AND RESPIRATORY SYSTEM 12 Hrs. Structure of gastrointestinal system, Mouth, Stomach, Salivary glands, Pancreas, Large intestine, Small intestine, Liver. Respiratory Tract, Physiology of respiration, Exchange of Oxygen and Carbondioxide, Pulmonary function tests, Control of Respiration, Artificial Respiration.

UNIT 3 ENDOCRINE AND NEURAL REFLEXES 12 Hrs. Endocrine glands – Hypothalamus and Pituitary gland, Thyroid gland, Endocrine function of Pancreas, Adrenal glands Structure of kidney, Nephron, Physiology of Urine formation, renal function tests, Micturition, Dialysis, Cystometerogram

UNIT 4 NERVOUS SYSTEM 12 Hrs. Neuron, Synapse, Neurotransmitters, Reflex activity, Spinal cord, EEG, Physiology of Pain, Physiology of sleep, Epilepsy, Cerebrospinal fluid (CSF), Regulation of body temperature.

UNIT 5 REPRODUCTIVE SYSTEM 12 Hrs. Male Reproductive System, Female Reproductive System, Menstrual cycle, Ovulation, Menopause, Pregnancy, Placenta, Pregnancy Tests, Fertility Control

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Guyton, Text book of Medical Physiology, WB jaunder company Philadelphia, 10th edition 2002 2. Cyrul A Keele and Eric Neil, Samsons Wrights Applied Physiology, Oxford University press, New Delhi – 1991 3. Ranganathan T S, Text Book of Human Anatomy, S. Chand and Company, New Delhi – 1994 4. Best and Taylor, The livery Body, BC Publication, New Delhi 1980 5. Benjamin-Cummings, Human Anatomy & Physiology 6th edition, Pearson 2007

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 21 REGULATIONS 2015

SBM5102 BIOSENSING TECHNOLOGIES L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE Presenting the student the underlying engineering principles used to detect small molecules, DNA, proteins, and

cells in the context of applications in diagnostic testing, pharmaceutical research, and environmental monitoring. Covers biosensor approaches including electrochemistry, fluorescence, acoustics, and optics; aspects of selective surface chemistry including methods for biomolecule attachment to transducer surfaces.

UNIT 1 INTRODUCTION 12 Hrs. Overview of Biosensors, Fundamental elements of biosensor devices, advantages and limitations, components of biological elements and their immobilization techniques. Sensor characteristics : linearity, repeatability, hysteresis, drift; Sensor models in the time & frequency domains.

UNIT 2 PHYSICAL & CHEMICAL SENSORS 12 Hrs. Sensors for physical measurands: pressure, acceleration, flow, volume, temperature and biopotentials. Sensors for measurement of chemicals: Potentiometric sensors, ion selective electrodes, ISFETS; Amperometric sensors, Clark Electrode; Biosensors, Catalytic biosensors, Immunosensors.

UNIT 3 TRANSDUCERS 12 Hrs. Characteristics- Static, Dynamic, Error in the measurements, Classification of transducers - Resistive, Capacitive, Inductive, Photoelectric, piezoelectric and mechanoelectronics, Principle of fiber optic cable, fiber optic sensors, Photo acoustic sensors..

UNIT 4 ELECTRODES & AMPLIFIERS 12 Hrs. Half cell potential, Reference electrodes, polarization effects, Polarisable and nonpolarisable electrodes, Micro electrodes, Equivalent Circuits, , Liquid and solid ion exchange membrane electrode, Enzyme electrode Signal Conditioning circuits- Characteristics of Amplifiers , Differential Amplifiers, Filters, A/D Converters.

UNIT 5 NON ELECTRICAL PARAMETER MEASUREMENTS 12 Hrs. Measurements of Respiration Rate, Temperature, Pulse rate, Blood pressure Measurements- Direct, Indirect, Blood flow Measurements – Invitro, Invivo, Gas flow measurements.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Richard S.C. Cobbold : Transducers for Biomedical Measurements: Principles and Applications, John Wiley & Sons, 1992 2. A.P.F. Turner, I. Karube & G.S. Wilson : Biosensors : Fundamentals & Applications, Oxford University Press, Oxford, 1987. 3. Rangan C.S., Sarma G.R., and Mani V.S.V., Instrumentation devices and system, Second Edition,Tata Mc Graw hill Publishing

Company limited, New Delhi, 2006. 4. John G.Webster, Medical Instrumentation, Application and Design, Third Edition, John willey and sons,1999 5. Jacob Kline, Handbook of Bio Medical Engineering, Academic press Inc., Sandiego, 1988.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 22 REGULATIONS 2015

SBM5103 ADVANCED BIOMEDICAL

INSTRUMENTATION L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE This study aims to provide the student with an advanced understanding of biomedical instrumentation, from signal

acquisition through to process control. It will link electrical engineering and physiological systems course content by applying the theory-based coursework in a similar context. The student will be prepared for a self-guided learning in this area.

UNIT 1 BIOMEDICAL SIGNALS & ELECTRODES 12 Hrs. Sources of biomedical signals, Basic medical instrumentation system, Origin of bioelectric signals - ECG, EEG, EMG. Electrodes for ECG, EEG, EMG, Medical surface electrodes and problems, Microelectrodes. Electrocardiograph-block diagram, ECG leads, Faults and troubleshooting, Phonocardiograph-origin of heart sounds, microphones and amplifiers for PCG, Operating Rooms

UNIT 2 ASSISTIVE DEVICES CARDIAC SYSTEM AND MONITORS 12 Hrs. Cardiac Pacemekers, Heart lung machine. Different types of Oxygenators, Pumps, Monitoring Process. Hemodialyser- Principle of Hemodialysis, Membranes, Dialyasate, Different types of heamodialysers, Wearable Artificial Kidney, Implantable Type. Defibrillators, Implantable defibrillators, Functional electrical stimulator (FES)

UNIT 3 RADIOLOGICAL, SURGICAL SCOPY AND DIATHERMY EQUIPMENTS 12 Hrs. Digital radiography, Digital Fluroscopy, Mammography, Angiography, Bone densitometry, Endoscopy, Laparoscopy Bronchoscopy, Gastroscopy, Physiological effects of HF radiation, Depth of Penetration, Short wave, Ultrasonic and microwave diathermy, Surgical diathermy,

UNIT 4 ULTRASONIC AND NEONATAL INSTRUMENTS 12 Hrs. Basic principles of Echo technique, display techniques A, B, M modes, Echo cardiograms, Echo encephalogram, Ultrasonic applied as diagnostic tool in ophthalmology, obstetrics and gynecology. Infusion Pumps. Baby incubator, Phototherapy, Radiant warmer - Working principle, block diagram, description, and function of basic blocks,

UNIT 5 BIOTELEMETRY, TELEMEDICINE AND SAFETY MEASUREMENTS 12 Hrs. Elements of Biotelemetry system, Design of a biotelemetry system, Implantable Units-Problems, Application of Telemetry in Patient Care. Fundamentals of Telemedicine, Block diagram of Telemedicine, Scope & Benefits and Limitation of Telemedicine. Applications –Teleradiography, Telecardiology, Telesurgery. Electric shock hazards –Gross shock, Effects on human body, Micro and macro electric shock, Leakage current and types, Testing of Biomedical Equipments.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Joseph J Carr and John M Brown – Introduction to Biomedical equipment Technology - Pearson Education 4th edition New

Delhi 2001. 2. Albert M Cook and Webster J G – Therapeutic medical devices Prentice Hall Nee York 1982 3. Webster J.G Medical Instrumentation application and design – John Wiley and sons New York 3rd edition 1999 4. Jacobson B and Webster J G Medical and Clinical Engineering – Prentice Hall of India New Delhi 1999 5. Leslie Cromwell , Fred J.Weibell and Erich A.Pfeiffer - Biomedical Instrumentation Prentice Hall New Delhi 2000 6. Khandpur R.S Hand Book of Biomedical Instrumentation – Tata McGraw Hill publication , New Delhi 2nd edition 2003 7. John Denis Enderle, Joseph D. Bronzino, Susan M. Blanchard, ‘Introduction to Biomedical Engineering:’Academic Press,

2005 , 2nd Edition ISBN 0122386620, 9780122386626

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 23 REGULATIONS 2015

SBM5104 ADVANCED MEDICAL IMAGE PROCESSING L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE The objective of this course is to provide students with an overview of the computational and mathematical

methods in medical image processing. The course covers all the main sources of medical imaging data. We will study many of the current methods used to enhance and extract useful information from medical images. A variety of radiological diagnostic scenarios will be used as examples to motivate the methods.

UNIT 1 IMAGE FUNDAMENTALS` 12 Hrs. Introduction fundamental steps in DIP – Simple image formation model, Representing digital Image, Spatial and grey level resolution, basic relationship between pixels. Image perception, Image model, Image sampling and quantization, Image transforms – 2D-DFT , The Fourier Transform and Spectral content -Modulation Transfer function-SNR-Measures-Application in Image sharpness and acutance

UNIT 2 NOISE MODELS, SEGMENTATION & COLOR IMAGE PROCESSING 12 Hrs. Noise models – Mean Filters – Order Statistics – Adaptive filters – Band reject Filters – Band pass Filters – Notch Filters – Optimum Notch Filtering – Inverse Filtering – Wiener filtering Segmentation: Detection of Discontinuities–Edge Linking and Boundary detection – Region based segmentation- Morphological processing- erosion and dilation. Colour Image processing: Introduction, Light and colour, colour formation, Human perception of colour, colour model, The chromaticity diagram, colour image quantization, Histogram of colour image, colour image filtering, colour image segmentation.

UNIT 3 MEDICAL IMAGE ENHANCEMENT AND ROI 12 Hrs. Gray scale transform- histogram Transformation-convolution mask operators-High frequency Emphasis- Homomorphic filtering-Adaptive contrast. S-Detection of objects of Known geometry-Methods of improvement of contour. Applications- Detection of spinal canal, Breast boundary, Pectoral muscle, Breast masses.

UNIT 4 ANALYSIS OF SHAPE, TEXTURE AND PATTERN 12 Hrs. Representation of shapes and contours-shape factor- Fourier descriptors- Application-Shape analysis of breast masses and tumors. Models for generation of texture- Statistical analysis- Fractal analysis-Segmentation and structural analysis of texture. Audification and sonification of texture in images. Application: Analysis of breast masses using texture and gradient measures.

UNIT 5 IMAGE REPRESENTATION, RECONSTRUCTION, RECOGNITION 12 Hrs. Boundary representation – Chain Code – Polygonal approximation, signature, boundary segments – Boundary description – Shape number – Fourier Descriptor, moments- Regional Descriptors –Topological feature, Texture – Patterns and Pattern classes – Projection geometry- Fourier Slice theorem- Back projection-Algebraic reconstruction ,Recognition based on matching.

Max. 60 Hours TEXT / REFERENCE BOOKS 1. Rangaraj M. Rangayyan, Biomedical Image Analysis, CRC Press LLC, Boca Raton, FL, 2005 2. Atam P.Dhawan, Medical Image Analysis, Wiley Interscience Publication, NJ, USA 2003. 3. R.C.Gonzalez and R.E.Woods, Digital Image Processing, Second Edition, Pearson Education, 2002. 4. Anil. K. Jain, Fundamentals of Digital Image Processing, Pearson education, Indian Reprint 2003. 5. Alfred Horowitz, MRI Physics for Radiologists – A Visual Approach, 2nd edition Springer Verlag Network, 1991. 6. Malay K. Pakhira, Digital Image Processing and Pattern Recognition, First Edition, PHI Learning Pvt. Ltd., 2011

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 24 REGULATIONS 2015

SBM5105 COMPUTER BASED MEDICAL

INSTRUMENTATION L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE With widespread use and requirements of medical instruments, this course gives knowledge of the principle of

operation and design of biomedical instruments. It attempts to render a broad and modern account of biomedical instruments. They will have knowledge of the principle operation and design and the background knowledge of biomedical instruments and specific applications of biomedical engineering.

UNIT 1 INTRODUCTION 12 Hrs. Generalized Instrumentation system - Feature of personal computer - PC based Instrumentation system - Principle of signal conditioning - Operational Amplifier – instrumentation amplifier- Bridge circuits –Half and Full Bridge Circuit, Filters - Noise reduction techniques.

UNIT 2 PRINCIPLE OF DATA ACQUISTION 12 Hrs. Sampling concepts – DAC- Weighted Resistor Network, R-2R Ladder Network, ADC – Successive Approximation ADC- Counting type, Successive approximation, parallel comparator ,Data acquisition system –Analog Input , Analog Output.

UNIT 3 HARDWARE ORGANIZATION OF PC 12 Hrs. Motherboard components – Microprocessor, memory, Chipset Chips, Interrupts, DMA Channel, System Control Chip , Peripheral Control Chip- Peripherals , Features of ISA and PCI buses.

UNIT 4 COMPUTERISED DATA ACQUISITION 12 Hrs. Overview of GPIB – System and Implementation, commands – primary command, secondary commands, evice specific commands, expanding GPIB , Sharing GPIB,SCPI- Generalized Instrument Model.

UNIT 5 DATA ACQUISTION USING SERIAL INTERFACE 12 Hrs. Serial Communication – Features and Formats, Interface standard – RS232 , RS-422, RS-485, PC, serial port – UART, Microcontroller serial interface – USB System and USB Transfer.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Mathivanan, PC-based instrumentation: concepts and practice, Prentice Hall India Pvt Ltd., 2007 2. Michael H. Tooley, PC-based instrumentation and control, 2nd Edition, Newnes Publications, 2003 3. Patrick H. Garrett, High performance Instrumentation and Automation, CRC Press, Taylor & Francis Group, 2005. 4. Atul Khate, Cryptography and network security, Tata McGraw Hill Publishing Company, New Delhi, 2008

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 67 REGULATIONS 2015

SBI6536 STATISTICS USING R PACKAGE LAB L T P C Total Marks 0 0 6 3 100

1. Working with R and R Studio. 2. Built-in mathematical functions and Simple summary statistics. 3. Reading data from excel files. 4. Transformation of variables, subsets of datasets and merging datasets. 5. Basic High level plots and Modifications of scatterplots, histograms and parallel boxplots. 6. Simple and multiple linear regression. 7. One way analysis of variables: Psoriasis. 8. Matrix operations and Least squares estimates in linear regression.

SBM6531 BIOMEDICAL INSTRUMENTATION LAB L T P C Total Marks

0 0 6 3 100

1. Design of ECG Amplifier using Instrumentation Amplifier 2. Heart Rate Measurement using modules ad trainer kit 3. Identification of Heart Sounds -PCG 4. Defibrillator 5. Design of Cardiac Pacemaker. 6. Study of Heart Lung Machine. 7. Study of Haemodialysis. 8. Study of Short wave Diathermy. 9. Surgical Diathermy 10. Simulation of ECG waveforms using MATLAB.

SBM6532 ADVANCED MEDICAL SIGNAL & IMAGE PROCESSING LAB

L T P C Total Marks

0 0 6 3 100

MEDICAL IMAGE PROCESSING 1. Study of Basic commands in MATLAB 2. Image Linear Filtering and Transforms 3. Image Segmentation 4. Image Restoration techniques 5. Image registration 6. Image Enhancement 7. Morphological Operation 8. Finding the ROIs’

MEDICAL SIGNAL PROCESSING 1. Least Squares, Orthogonality, and Fourier series 2. Correlation, Fourier Spectra and the Sampling Theorem 3. Linear systems and Transfer Function 4. FIR Filter Design for Biomedical signal processing 5. IIR Filter Design for Biomedical signal processing 6. Study of ECG, EMG, EEG Signal Analysis 7. ECG noise cancellation 8. Biomedical Signal Compression

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 3 REGULATIONS 2015

SEC5120 EMBEDDED SYSTEM DESIGN (For PEID, MI)

L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVES To study the ARM processor and ARM instruction sets To understand RTOS concepts and Embedded networking concepts To understand basic ARM interfacing

UNIT 1 ARM ARCHITECTURE 12 Hrs. ARM Architecture ARM Design Philosophy, Registers, Program Status Register, Instruction Pipeline, Interrupts and Vector Table, Architecture Revision, ARM Processor Families.

UNIT 2 ARM INSTRUCTION SET 12 Hrs. Data Processing Instructions, Addressing Modes, Branch, Load, Store Instructions, PSR Instructions, Conditional Instructions. Thumb Instruction Set: Register Usage, Other Branch Instructions, Data Processing Instructions, Single Register and Multi Register Load -Store Instructions, Stack, Software Interrupt Instructions

UNIT 3 REAL TIME OPERATING SYSTEM 12 Hrs. Real time operating systems (RTOS) – real time kernel – OS tasks – task states – task scheduling – interrupt processing – clocking communication and synchronization – control blocks – memory requirements and control – kernel services.

UNIT 4 EMBEDDED NETWORKS 12 Hrs. Embedded Networks - Distributed Embedded Architecture – Hardware and Software Architectures, Networks for embedded systems– I2C, CAN Bus, Ethernet, Internet, Network–Based design– Communication Analysis, system performance Analysis, Hardware platform design, Allocation and scheduling, Design Example: Elevator Controller.

UNIT 5 SYSTEM DESIGN 12 Hrs. Switches and LED interfacing-LCD Display interfacing- Analog sensors interfacing for digital data conversion -Access control using analog keypad - Pulse width modulation technique for motor speed control

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Andrew N.Sloss, Dominic Symes, Chris Wright, ARM Systems Developer’s Guide: Designing & Optimizing System Software,

Elsevier, 2004. 2. Jonathan W. Valvano, Embedded Microcomputer Systems: Real Time Interfacing, Cengage Learning, 2011 3. Wayne Wolf, Computers as Components: Principles of Embedded Computing System Design, Morgan Kaufman Publishers,

2008. 4. C.M. Krishna, Kang G. Shin, Real time systems, Mc-Graw Hill, 3rd reprint, 2010. 5. Herma K., Real Time Systems: Design for Distributed Embedded Applications, Kluwer Academic Publishers, 1997. 6. William Hohl, ARM Assembly Language, Fundamentals and Techniques, Taylor & Francis, 2009.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 25 REGULATIONS 2015

SBM5106 BIO SIGNAL PROCESSING L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE This course presents the application of the main signal processing tools to the analysis of biomedical signals. It

shows how clinically relevant information can be extracted from these signals. The processing techniques will be illustrated with examples of their application in the analysis of the electrocardiogram (ECG), electroencephalogram (EEG), evoked potentials (EP), heart rate variability (HRV) and other signals.

UNIT 1 INTRODUCTION TO BIOMEDICAL SIGNALS 12 Hrs. Bioelectric signals-Action potential, Electro-neurogram, Electro-oculogram, Electro-encephalogram, Evoked potential, Electro-cardiogram, Electro-gastrogram, bio-impedance signals - COURSE OBJECTIVES of biomedical signal analysis, difficulties in biomedical signal analysis.

UNIT 2 REAL TIME TRANSFORMS 12 Hrs. Convolution – Linear Convolution, Circular Convolution, Correlation – Auto Correlation, Cross Correlation, DFT, and FFT – DIT & DIF Algorithms, Real Time Transforms: Discrete Cosine Transform, Walsh Transform, Hadamard Transform and Wavelet Transform.

UNIT 3 EVENT DETECTION 12 Hrs. Detection of events and waves – Derivative based operators in QRS detection – Pan Tompkins algorithm - Correlation analysis- ACF and CCF in rhythm analysis – Cross - spectral techniques - Murmur detection - Homomorphic filtering – Matched filters – Wavelet detection – Spike and wave detection-Extraction of vocal tract response and other applications.

UNIT 4 ECG DATA REDUCTION 12 Hrs. Direct data compression Techniques: Turning Point, AZTEC, Cortes, FAN, Transformation Compression Techniques: Karhunen-Loeve Transform, Other data compression Techniques: DPCM, Huffman coding, Data compression Techniques comparison

UNIT 5 FILTERING 12 Hrs. Time domain filtering – Synchronous averaging, Moving average filters, Frequency domain filters – Design of Butterworth filters- optimal filtering, Adaptive noise cancellation - LMS and RLS algorithms in adaptive filtering – Application of these techniques in removal of artifacts in bio-signals.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Arnon Cohen, Bio-Medical Signal Processing Vol I and Vol II, CRC Press Inc., Boca Rato, Florida 1999. 2. Rangaraj M. Rangayyan, ‘Biomedical Signal Analysis-A case study approach’, Wiley- Interscience/IEEE Press, 2002 3. Willis J. Tompkins, Biomedical Digital Signal Processing, Prentice Hall of India, New Delhi, 2003. 4. Raghuveer M. Rao and Ajith S.Bopardikar, Wavelets transform – Introduction to theory and its applications, Pearson

Education, India 2000. 5. Dr.P. Ramesh Babu, Digital Signal Processing Scitech Publications, Fourth Edition 2010 6. D.C.Reddy, Biomedical Signal Processing – Principles and Techniques, TMH,New Delhi,2005 7. Avtar Singh and S Srinivasan, Digital Signal Processing, Thomson Publishing 2004, Singapore.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 63 REGULATIONS 2015

SEC6540 EMBEDDED SYSTEMS AND CIRCUITS LAB (For MI)

L T P C Total Marks

0 0 6 3 100

Experiments based on Analog Integrated Circuits i) Basic inverting adder, non inverting adder, unity follower. ii) Instrumentation Amplifier iii) High pass, low pass and band pass filter design iv) Comparator and wave form generator.

Experiments based on Advanced Digital System Design i) Half and full adder ii) Half and full subtractor iii) Study of basic flip flops iv) Study of registers and counters.

Experiments based on Advanced Microcontrollers & Embedded Systems i) Basic system design using PIC microcontroller. ii) Basic system design using AVR microcontroller. iii) Study of ARM Processor.

SBI6531 PERL PROGRAMMING AND BIOLOGICAL DATABASES LAB

L T P C Total Marks 0 0 6 3 100

PERL PROGRAMMING LAB 1. Perl basics and variables 2. Control and loop statements 3. To find greatest of 3 numbers 4. To check whether a number is prime or not 5. Generating fibonacci series 6. To perform matrix addition & multiplication 7. Functions and subroutines 8. Command line argument 9. Regular expressions 10. Perl web server 11. Modules:LWP 12. Translate DNA to protein by using perl module 13. Program to perform file handling, concatenation& string length 14. Program- shift, unshift, splice & slice 15. Program to perform until, for, for each, while operations 16. Program to perform GC count, chop, chomp, reverse compliment 17. File handling using arrays and scoping of variables 18. BIOPERL: objects in Bioperl, using Bioperl

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 26 REGULATIONS 2015

SBM5201 ADVANCED REHABILITATION ENGINEERING L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE This course is an introduction to a field of engineering dedicated to improving the lives of people with disabilities.

Rehabilitation engineering is the application of engineering analysis and design expertise to overcome disabilities and improve quality of life. A range of disabilities and assistive technologies will be investigated. The relationship between engineering innovation, the engineering design process, the human-technology interface, and the physical medicine and rehabilitation medical community will be explored.

UNIT 1 INTRODUCTION 12 Hrs. Introduction to Rehabilitation Engineering, Principles involved in rehabilitation engineering. Assistive Technology, Steps in patient management, Epidemiology of Rehabilitation, Health, Levels of Prevention, Preventive Rehabilitation, Diagnosis of Disability and Functional Diagnosis, Medical Rehabilitation, Telerehabilitation, Vocational Rehabilitation

UNIT 2 ERGONOMICS & REHABILITATION TEAM 12 Hrs. Ergonomics: Introduction to Ergonomics, Principles of Ergonomics, , Developing an Ergonomic Program, Ergonomic Issues Related to Posture, Frequent Types of Injuries Related to Workplace Design, Occupational and Human Stress. Rehabilitation Team: The Role of Physiatrist, Occupational Therapist, Physical Therapist, Prosthetist - Orthotist, Rehabilitation nurse & biomedical engineer. Burn injury rehabilitation.

UNIT 3 ORTHOTICS AND PROSTHETICS 12 Hrs. Orthotics, Classification of orthotics, General principles of orthotics, Biomechanics of orthotics, Material design consideration in orthotics, Different types of orthotics – Spinal, Cervical, Thoracic, TLSO, LSO. Fundamentals, FES Systems - Restoration of Hand Functions, Restoration of Standing & Walking, Hybrid Assistive systems. Active Prostheses - Active above knee prostheses, Myoelectric Hand and Arm Prostheses.

UNIT 4 NEURO-PROSTHETICS 12 Hrs. Sensory prosthetics-visual prosthetics-Bionic eye-retinal prosthetic-auditory prosthetics-cochlear implant-Auditory brain stem implant- bionic ear- spinal cord stimulator- Motor prosthetics- bladder control implant-sacral anterior root stimulator-prosthetics for conscious control of movements-Brain computer interface

UNIT 5 COMMUNICATION SYSTEMS & MOBILITY AIDS 12 Hrs. Communication systems: Augmentative communication - general form of communication, types of visual aids, Hearing aids, Types of conventional hearing aid, Writing aids. Mobility Aids: Walking frames, Parallel bars, Rollators, Quadripods, Tripods & walking sticks, Crutches, Wheel chairs, specialized wheel chairs.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Dr.S.Sunder , Rehabilitation Medicine , Jaypee Medical Publications,2010. 2. Joseph D.Bronzino , The Biomedical Engineering Handbook Volume-II, Second Edition, CRC Press 2006 3. G. Salvendy, Handbook of Human Factors and Ergonomics, Wiley, 3 edition 2006. 4. Kondraske, G. V, Rehabilitation Engineering, CRC press 1995 5. Robinson C.J., Rehabilitation Engineering Handbook of Electrical Engineering, CRC Press, Bocaration 1993. 6. Susan B O'Sullivan, Thomas J Schmitz, George Fulk, Physical Rehabilitation, Davis Plus, 2014

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 67 REGULATIONS 2015

SBI6536 STATISTICS USING R PACKAGE LAB L T P C Total Marks 0 0 6 3 100

1. Working with R and R Studio. 2. Built-in mathematical functions and Simple summary statistics. 3. Reading data from excel files. 4. Transformation of variables, subsets of datasets and merging datasets. 5. Basic High level plots and Modifications of scatterplots, histograms and parallel boxplots. 6. Simple and multiple linear regression. 7. One way analysis of variables: Psoriasis. 8. Matrix operations and Least squares estimates in linear regression.

SBM6531 BIOMEDICAL INSTRUMENTATION LAB L T P C Total Marks

0 0 6 3 100

1. Design of ECG Amplifier using Instrumentation Amplifier 2. Heart Rate Measurement using modules ad trainer kit 3. Identification of Heart Sounds -PCG 4. Defibrillator 5. Design of Cardiac Pacemaker. 6. Study of Heart Lung Machine. 7. Study of Haemodialysis. 8. Study of Short wave Diathermy. 9. Surgical Diathermy 10. Simulation of ECG waveforms using MATLAB.

SBM6532 ADVANCED MEDICAL SIGNAL & IMAGE PROCESSING LAB

L T P C Total Marks

0 0 6 3 100

MEDICAL IMAGE PROCESSING 1. Study of Basic commands in MATLAB 2. Image Linear Filtering and Transforms 3. Image Segmentation 4. Image Restoration techniques 5. Image registration 6. Image Enhancement 7. Morphological Operation 8. Finding the ROIs’

MEDICAL SIGNAL PROCESSING 1. Least Squares, Orthogonality, and Fourier series 2. Correlation, Fourier Spectra and the Sampling Theorem 3. Linear systems and Transfer Function 4. FIR Filter Design for Biomedical signal processing 5. IIR Filter Design for Biomedical signal processing 6. Study of ECG, EMG, EEG Signal Analysis 7. ECG noise cancellation 8. Biomedical Signal Compression

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 76 REGULATIONS 2015

SEC5669 DIGITAL SIGNAL PROCESSOR (For MI)

L T P C Total Marks

3 1 0 4 100

COURSE OBJECTIVE To develop skills for analyzing and synthesizing algorithms and systems that process discrete time signals, with emphasis on realization and implementation. After the course, the students will be able to understand how to analyze a given signal or system using relevant tools, what kind of characteristics should we analyze to know the property of a signal or system; how to process signals to make them more useful; and how to design a signal processor (digital filter) for a given problem. Throughout the course, the integration of digital signal processing concepts in a design environment is emphasized.

UNIT 1 INTRODUCTION TO DSP INTEGRATED CIRCUITS 12 Hrs. Introduction to Digital signal processing, Sampling of analog signals, Selection of sample frequency, Signal processing systems, Frequency response, Transfer functions, Signal flow graphs, Adaptive DSP algorithms- LMS & RLS Standard digital signal processors, Application specific IC’s for DSP, DSP systems, DSP system design, Integrated circuit design.

UNIT 2 DIGITAL FILTERS AND FINITE WORD LENGTH EFFECTS 12 Hrs. FIR filters- Design of Linear Phase FIR Filter,FIR filter structures- Direct Form, transposed Direct Form, IIR filters, Specifications of IIR filters, Mapping of analog transfer functions, Mapping of analog filter structures, Finite word length effects –Parasitic oscillations- Zero Input Oscillation, Overflow Oscillation, Periodic input Oscillation, Quantization- Truncation, Rounding, Error due to truncation and rounding. Finite word length effects in FIR Digital Filters.

UNIT 3 DSP ARCHITECTURES 12 Hrs. DSP system architectures, Standard DSP architecture-Harvard and Von Neumann Architecture. TMS320C50, TMS320C50x and TMS320C6x architecture, Motorola DSP56002 architecture, Ideal DSP architectures, Multiprocessors and Multi computers,.

UNIT 4 SYNTHESIS OF DSP ARCHITECTURES AND ARITHMETIC UNIT 12 Hrs Mapping of DSP algorithms onto hardware, Uniprocessor Architecture

Arithmetic Unit Conventional number system, Redundant Number system, Residue Number System, Bit-parallel and Bit-Serial arithmetic.

UNIT 5 CASE STUDY-INTEGRATED CIRCUIT DESIGN 12 Hrs. Layout of VLSI circuits, Layout Styles,

Case Study FFT processor, DCT processor and Interpolator.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Lars Wanhammer, DSP Integrated Circuits, Academic press, New York, 1999. 2. John J. Proakis, Dimitris G. Manolakis, Digital Signal Processing, Pearson Education, 2002. 3. B.Venkatramani, M.Bhaskar, Digital Signal Processors, Tata McGraw-Hill, 2002. 4. Emmanuel C. Ifeachor, Barrie W. Jervis, Digital signal processing – A practical approach, Tata McGraw-Hill, 2002. 5. Keshab K.Parhi, VLSI Digital Signal Processing Systems design and Implementation, John Wiley & Sons, 1999.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs PART A : 6 Questions of 5 marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M.E. / M.Tech REGULAR 77 REGULATIONS 2015

SIC5617 ROBOTICS AND ARTIFICIAL INTELLIGENCE L T P C Total Marks

3 1 0 4 100

COURSE OBJECTIVE The course covers fundamentals of robot working, programming and integration. To develop the student’s understanding of the issues involved in trying to define and simulate intelligence and to familiarize the student with specific, well known AI methods, algorithms and results and to provide the student additional experience in the analysis and evaluation of complicated systems.

UNIT 1 INTRODUCTION TO ARTIFICIAL INTELLIGENCE 12 Hrs. Definition, AI versus Natural Intelligence, Defining a problem- characteristic, Search, Production Systems- characteristics, issues in design of search programs, heuristic search technique - hill climbing, best first search, problem reduction.

UNIT 2 KNOWLEDGE REPRESENTATION 12 Hrs. Representation and mapping, Knowledge Types, Knowledge representation using rules, predicate logic, symbolic reasoning under uncertainty, statistical reasoning- probability and bayes’ theorem, Dempster-Shafer theory. Characteristic of AI language- PROLOG and LISP definition.

UNIT 3 INTRODUCTION TO ROBOTICS 12 Hrs. Classification of robots, basic robot components, manipulator end effectors, controller, accuracy precision and repeatability. Robotic vision system, Position, velocity and acceleration sensors, proximity and range sensors, touch and slip sensors, tactile sensors, and force and torque sensors.

UNIT 4 ROBOT MOTION ANALYSIS 12 Hrs. Manipulator Kinematics, Inverse Manipulator Kinematics, Manipulator Dynamics-Newton-Euler and Lagrange formulation

UNIT 5 ROBOT APPLICATIONS 12 Hrs. Material transfer and machine loading /unloading, processing applications, welding and painting assembly and inspection, future robotic applications and related technologies developments.

Max. 60 Hours.

TEXT / REFERENCE BOOKS 1. Mikell P. Groover, Mite chell Weiss, Roger Negal and Nicholes G.Odress. Industrial Robotics – Technology – Programming

and Applications - McGraw-Hill, Latest edition. 2. Fu, Gonzalez And Lee: Robotics: Control, Sensing, Vision And Intelligence, McGraw-Hill,1987 3. Elaine Rich And Kevin Knight, Artificial Intelligence, McGraw-Hill, 1983 4. George F. Luger, Artificial Intelligence – Structures and Strategies for Complex Problem Solving, 4

th Edition, Pearson

Education, 2003. 5. Russell & Norvig, second edition, Artificial Intelligence ‘a Modern Approach, Pearson Education, 2003. 6. Dan W.Patterson, Introduction to Artificial Intelligence and Expert Systems- Prentice Hall of India,1990

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks: 80 Exam Duration: 3 Hours PART A : 6 Questions of 5 marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 96 REGULATIONS 2015

SBM5601 PHYSIOLOGICAL CONTROL SYSTEMS L T P Credits Total Marks 3 1 0 4 100

COURSE OBJECTIVE The main objective of this course is to provide background knowledge on specific physiological systems (nervous

system, sensory systems, muscle control systems, cardiovascular systems, respiratory system, hormonal control mechanisms) and to apply control theory, system analysis, and model identification techniques to better understand the processes involved in physiological regulation. In this course, besides qualitative descriptions of physiological systems, we shall be dealing with the mathematical modeling and computer simulation of these models. Mathematical modeling of a physiological system results in a description in terms equations, usually differential equations, chosen to describe the dynamic aspects of the system.

UNIT 1 INTRODUCTION 12 Hrs. System Analysis fundamental Concepts, Physiological control systems analysis with simple example, Differentiate between Engineering and physiological control system, The science of modeling, Control system: open loop system, closed loop system, Feed back, Mathematical model of mechanical translational and mechanical rotational systems, Electrical analogus of mechanical translational and mechanical rotational system, Transfer function.

UNIT 2 MATHEMATICAL MODELING 12 Hrs. Generalized System properties, Models with combinations of system elements, Linear models of Physiological Systems with Examples, Distributed-parameter versus Lumped-parameter model, Linear systems and the superposition principle.

UNIT 3 STATIC ANALYSIS OF PHYSIOLOGICAL SYSTEMS 12 Hrs. Open-Loop versus Closed-Loop Systems, Determination of the Steady-State Operating Point, Regulation of Cardiac Output, Regulation of Glucose, Chemical regulation of Ventilation.

UNIT 4 TIME RESPONSE & FREQUENCY RESPONSE ANALYSIS OF LINEAR SYSTEM 12 Hrs. Standard test signals, Response of First-Order & Second Order for unit step as input, Bode plot, Polar plot, Transient Response Descriptors. Frequency Response of a Model of Circulatory Control, Frequency Response of Glucose –Insulin - Regulation.

UNIT 5 STABILITY ANALYSIS AND IDENTIFICATION OF PHYSIOLOGICAL CONTROL SYSTEMS 12 Hrs. Root Locus, Routh-Hurwitz Stability Criterion, Stability Analysis of Pupillary Light Reflex (Using Routh-Hurwitz Analysis), Model of Cheyne - Stokes Breathing. Identification of Physiological Control Systems: Basic Problems in Physiological Analysis, The Starling Heart-lung preparation.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Michael C.K. Khoo, Physiological Control System - Analysis, Simulation and Estimation- Prentice Hall of India, New Delhi,

2001 2. William B. Blesser, A System Approach to Biomedicine, McGraw Hill Book Co, New York, 1969. 3. Manfreo Clynes and John H. Milsum, Biomedical Engineering System, McGraw Hill and Co, New York, 1970. 4. Douglas S. Rigg, Control Theory and Physiological Feedback Mechanism, The William and Wilkins Co, Baltimore, 1970. 5. Richard Skalak and Shu Chien, Hand Book of Biomedical Engineering, McGraw Hill and Co, New York, 1987.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 97 REGULATIONS 2015

SBM5602 MEMS IN HEALTHCARE L T P Credits Total Marks 3 1 0 4 100

COURSE OBJECTIVE This course introduces students to Micro Electro Mechanical Systems (MEMS), small devices that perform tasks

and functions involving various types of signals, and teaches the fundamentals of micromachining and microfabrication. Students will also learn the basics for designing and analyzing devices and systems in mechanical, electrical, fluidic, and thermal energy/signal domains, as well as basic techniques for multi-domain analysis.

UNIT 1 MEMS AND MICROSYSTEMS 12 Hrs. Mems and Microsystems-General principles, advantages, Materials for bio-MEMS and their properties. Technology involved in MEMS. Fabrication techniques- Lithography- etching- Ion implantation- wafer bonding. Integrated processing- Bulk Micro machining- Surface micro machining- coating technology and CVD- LIGA process..

UNIT 2 MICROSENSORS AND TISSUE MICROENGINEERING 12 Hrs. Introduction to biomimetic substrates, microscaffolds, cellular co-cultures. Microsensors and Microactuators –working principle, types- pressure sensors, thermal sensors and actuators, piezoelectric crystals-Intelligent materials and structures, Magnetic sensors and actuators- magnetic materials used for MEMS.

UNIT 3 MOEMS AND MICROFLUIDIC SYSTEM 12 Hrs. Principle of MOEMS- light modulator, beam splitter, digital micro mirror device, light detectors and optical switch. Micro fluidic System- Fluid actuation method, dielectrophoresis, micro fluid dispenser, micro needle, micro pumps. Applications of BioMEMS - Healthcare, drug delivery, micrototal analysis system detection and measurement methods,

UNIT 4 INTRODUCTION TO NANOTECHNOLOGY 12 Hrs. Essence of Nanotech, Nanofying electronics, Properties of nanomaterials, metal nano clusters, semiconductor nano particles, nano composites. Introduction to carbon nano structure, carbon molecules, carbon clusters, nanotubes- application. UNIT 5 MEDICAL APPLICATIONS OF NANOTECHNOLOGY 12 Hrs. Nanotechnology and Biomedicine-Drug synthesis and delivery–-nano fabrication methods- biomimetic nanodevices nanomaterials in human body- toxicity in nanomaterials.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Tai Ram Hsu, Mems and Microsystems,Design and Manufacture, TMH2002. 2. Mohammed had-el-hak, MEMS Introduction & Fundamentals, CRC Press, 2005. 3. Marc J. Madou, Fundamentals of Microfabrication and Nanotechnology, Third Edition, 2011, CRC Press. ISBN

9780849331800 4. Harsingh Nalwa, Encyclopedia of Nanoscience and Nanotechnology, American Scientific Publishers. 2004. 5. Neelina Malsch, Biomedical Nanotechnology. CRC, 2005 6. Richard Booker and Earl Boysen, Nanotechnology For Dummies, John Wiley & Sons, 2011

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks .

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 98 REGULATIONS 2015

SBM5603 COMPUTERS IN MEDICINE L T P Credits Total Marks 3 1 0 4 100

COURSE OBJECTIVE This course is an introduction to the most important technical, clinical, and social aspects of health information

technology as they relate to clinical research. At the conclusion of this course, students will be familiar with core concepts in medical informatics: vocabularies, interchange standards, decision support systems; Understand how computers are used to manage information in health care and to support clinical research; Be familiar with pros and cons of using health information technology in the care setting for care or research.

UNIT 1 HEALTH INFORMATICS & MEDICAL STANDARDS 12 Hrs. Introduction, Needs of computers in medicine, Historical highlights and Evolution, Hospital Information System – its characteristics and functional online and offline modules, e – health services, Medical Standards – HL7 – DICOM – PACS, Medical data formats – Bioethics.

UNIT 2 MEDICAL INFORMATICS 12 Hrs. Definitions and its six levels of interfacing, Electronic Patient Records - Biometrics, Telemedicine – Technologies and applications, Evidence Based Medicine, Virtual Reality and Multimedia applications in Medicine – Virtual Hospital

UNIT 3 BIOMEDICAL INFORMATION TECHNOLOGY 12 Hrs. Genesis of JAVA, Data types, Operators, Control statements, Classes – Inheritance – packages and interfaces – I/O applets, String handling Applet Classes – AWT and Swing classes - Java applets, Java servelets, Java script programming, Creating events, interactive forms, frames, documents, spread sheets and windows- Client – Server programming

UNIT 4 MEDICAL DATA COMPRESSION, STORAGE AND RETRIEVAL 12 Hrs. Introduction, Picture Compression, Compression in the DICOM Standard, Data Compression for Dynamic Functional Images, Content-Based Medical Image Retrieval: Image Retrieval by Physical Visual Features, Geometric Spatial Filters, Combination of Semantic and Visual Features and Physiologically functional features.

UNIT 5 DATA COMMUNICATION, NETWORK INFRASTRUCTURE AND SECURITY 12 Hrs. Transmission and Communication Technologies, The Internet and World Wide Web, Wireless an Mobile Technologies in M-Health, Sensor Networks for Health Monitoring, Applications of Wireless Technologies in Telemedicine, Overview of Cryptographic system, Digital Watermarking, Medical Image Watermarking, Region-Based Reversible Watermarking for Secure Positron Emission Tomography Image Management.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Ramachandra Lele, Computers in Medicine Progress in Medical Informatics, Tata McGraw Hill Publishing Company, New

Delhi, 2005 2. Herbert Schildt, The Complete Reference – JAVA, Tata McGraw Hill Publishing Company, New Delhi, 2005 3. Mohan Bansal M S, Medical Informatics, Tata McGraw Hill Publishing Company, New Delhi, 2005 4. David Dagan Feng , Biomedical information technology, Academic Press series in Biomedical Engineering 2008.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 99 REGULATIONS 2015

SBM5604 MEDICAL IMAGING TECHNIQUES &

SYSTEMS L T P Credits Total Marks 3 1 0 4 100

COURSE OBJECTIVE The aim of this course is to enable students to develop a basic familiarity with all the major medical imaging

techniques employed in modern hospitals, including x-ray imaging, computer tomography, magnetic resonance imaging, ultrasound, nuclear isotope imaging, and electroencephalography. Each technique will be introduced in the context of the underlying clinical requirements. Students need to learn what physical principles are involved, and what properties of tissues the corresponding medical images show. The course will aim to develop an understanding of the historical evolution of these imaging methods, as well as indicate how medical imaging is likely to develop over the next few years.

UNIT 1 INTRODUCTION 12 Hrs. Basic imaging principle image modalities, interaction between X – Rays and matter, Intensity of an X – Ray, Attenuation, X – Ray Generation and Generators, Beam Restrictors and Grids, Intensifying screens, fluorescent screens and image intensifiers, X – Ray detectors, Conventional X – Ray radiography, Fluoroscopy, Angiography, Digital radiography. INFRA RED IMAGING Physics of thermography – imaging systems – pyroelectric vidicon camera clinical thermography – liquid crystal thermography

UNIT 2 COMPUTED TOMOGRAPHY 12 Hrs. Basic Principle, Generation of CT machines, Detectors & Detector arrays, Details of Acquisition, Digital image display Radiation Dose, Image quality.

UNIT 3 ULTRASOUND 12 Hrs. Acoustic propagation, Attenuation, Absorption and Scattering, Ultrasonic transducers, Transducer Arrays, A mode, B mode, M mode scanners, Tissue characterization, Color Doppler flow imaging, Echocardiography.

UNIT 4 MAGNETIC RESONANCE IMAGING 12 Hrs. Angular momentum, Magnetic dipole moment, Magnetization, Larmor frequency Rotating frame of reference, free induction decay, Relaxation times, Pulse sequences, Generation and Detection of NMR Imager, Slice selection, Frequency encoding, Phase encoding, Spin – Echo imaging, Gradient – Echo imaging, Imaging safety, Biological effects of magnetic field, Introduction to FMRI, EMRI.

UNIT 5 RADIO NUCLIDE IMAGING 12 Hrs. Interaction of nuclear particles and matter, nuclear sources, nuclear radiation detectors, rectilinear scanner, scintillation camera, SPECT, PET, Gamma ray camera, LINAC.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. K Kirk Shung, Michael B smith & Benjamim M W Tsui, Principles of Medical Imaging, Academic press inc, First Edition 1992. 2. Jerry L Prince & Jonathan M Links, Medical Imaging Signals and Systems, Pearson Prentice Hall, First Edition 2006. 3. Jerrold T. Bushbery, The essential physics of medical imaging, Wolters kluwer health, 3rd 2011. 4. R S Khandpur, Hand Book of Biomedical Instrumentation, Tata McGraw Hill Publication, Second Edition. 2003. 5. Ray H Hashemi , William G Bradley, Christopher, J. Lisanti, Basics of MRI, 2010. 6. Frederick W Kremkau, Diagnostic Ultrasound Principles & Instruments, 5th Edition, Saunders Elsevier, 2005. 7. Steve Webb, The physics of medical imaging, Adam Hilger, Bristol, England,Philadelphia, USA, 1988. 8. Divyendu Sinha & Edward R.Dougherty, Introduction to Computer Based ImagingSystems, PHI, 2003

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 100 REGULATIONS 2015

SBM5605 BIOMATERIALS AND ARTIFICIAL ORGANS L T P Credits Total Marks 3 1 0 4 100

COURSE OBJECTIVE This course is designed to provide a general understanding of the multidisciplinary field of biomaterials. Course

materials will rely on general concepts learned in polymer and biology/biochemistry courses and will further extend the understanding about the interactions at the interface of material and biological systems. Current applications of biomaterials will be evaluated to provide an understanding of material bulk and surface properties, degradation processes, various biological responses to the materials and the clinical context of their use.

UNIT 1 INTRODUCTION 12 Hrs. Overview of Biomaterials, metallic biomaterials, Ceramic biomaterials, Polymeric biomaterials, Composite biomaterials, biodegradable polymers.

UNIT 2 TISSUE RESPONSE TO IMPLANTS 12 Hrs. Tissue grafts, Hard tissue replacements – Wires, pins and Screws, Joint replacements – Upper extremity and Lower extremity, Soft tissue replacements – sutures, skin and maxillofacial implants, Normal Wound healing process, Blood Compatibility

UNIT 3 HARACTERIZATION OF OPTHALMIC AND DENTAL MATERIALS 12 Hrs. Corrosion of metallic implants, Contact lenses, Optical implants, Eye Shields, Artificial tears, Dental materials, Oral implants, use of collagen in dentistry

UNIT 4 BLOOD INTERFACING IMPLANTS 12 Hrs. Neural and neuromuscular implants, Vascular implants, heart valve implants, heart and lung assist devices, artificial heart, cardiac pacemakers, Cardiac defibrillators, artificial kidney, Dialysis, Artificial blood.

UNIT 5 TRANSPLANTS 12 Hrs. Overview, Immunological considerations, individual organs – kidney, liver, heart and lung, bone, cornea, Skin and hair, Pancreas, Mechanism of allograft rejection, Regeneration and ethical considerations, Immunosuppressive drugs.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. J D Bronzino, Biomedical Engineering handbook, CRC Press / IEEE Press, Volume 2, 2nd edition, 2000. 2. R S Khandpur, Handbook of Biomedical Instrumentation, Tata McGraw Hill, - 2nd edition 2003 3. Joon B Park, Biomaterials – An Introduction, Plenum press, New York, - 2nd edition 1992. 4. Sujata V Bhat, Biomaterials – Narosa Publishing House Pvt Ltd, 2nd edition, 2009

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 101 REGULATIONS 2015

SBM5606 PATTERN RECOGNITION AND

APPLICATIONS

L T P Credits Total Marks 3 1 0 4 100

COURSE OBJECTIVE To equip the student with basic mathematical and statistical techniques, pattern recognition algorithms commonly

used in pattern recognition, and thereby to help understand, compare and contrast various pattern recognition techniques and to provide adequate background on probability theory, statistics, and optimization theory to tackle a wide spectrum of engineering problems.

UNIT 1 INTRODUCTION 12 Hrs. Machine perception, an example, Pattern Recognition System, The Design Cycle, Learning and Adaptation, Architecture of Pattern recognition system,

UNIT 2 MAXIMUM – LIKELIHOOD AND BAYESIAN PARAMETER ESTIMATION 12 Hrs. Bayesian Decision Theory: Minimum Error Rate Classification, Classifiers, Discriminant functions, and decision surfaces, Introduction to Maximum-likelihood estimation; Bayesian Estimation; Bayesian parameter estimation: Gaussian Case, general theory; Hidden Markov Models.

UNIT 3 UNSUPERVISED CLASSIFICATION 12 Hrs. Clustering for unsupervised learning and classification, clustering concepts C- means algorithm - hierarchical clustering - Graph theoretic approach to pattern clustering- Validity of clustering solutions.

UNIT 4 FEATURE EXTRACTION 12 Hrs. KL Transforms - feature selection through functional approximation - Binary selection Elements of formal grammars, syntactic description, stochastic grammars, Structural representation.

UNIT 5 INTRODUCTION TO BIOMETRICS 12 Hrs. Identification Methods, Biometric Technologies, Automatic Identification, Fingerprint verification, Face recognition, Hand Geometry based verification, Retina Identification, DNA based identification, Smart card based authentication.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Richard O. Duda, Peter E. Hart, and David G.Stork, Pattern Classification, 2nd Edition, Wiley-Interscience, 2001. 2. Earl Gose, Richard Johnsonbaugh, Steve Jost, Pattern Recognition and Image Analysis, Pearson Education, 2007. 3. K. Jain, R. Bolle, S. Pankanti, Biometrics: Personal Identification in Networked Society, Kluwer Academic, 1999.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 102 REGULATIONS 2015

SBM5607 HOSPITAL HEALTH SYSTEMS AND

MANAGEMENT

L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE To enable the student to develop adequate knowledge and mastery of techniques relevant to Hospital

Management and/or to demonstrate a clear understanding of concepts, information and techniques at the forefront of the hospital management discipline. To help develop awareness of the responsibilities in Hospital Management, including understanding the role and functions of hospitals and their health care context and prepare to handle the management and development issues faced by a hospital manager and to recognize how operational problems and situations are handled in practice by undertaking and reporting at a hospital attachment. To also formulate ideas and develop and participate in implementation of plan and to take a proactive and self-reflective role in working and to develop professional expertise.

UNIT 1 PRINCIPLE OF HOSPITAL MANAGEMENT 12 Hrs. Importance of management and Hospital, Management control systems. Forecasting techniques decision-making process, Hospital Administration

UNIT 2 EVOLUTION OF HOSPITAL 12 Hrs. Outpatient Department, Inpatient Service, Operation Theatre Complex, Delivery Suite, Pharmacy, Laboratory services, Radiological Department, Central Sterile supply department, and Medical records department, Material management, Hospital dietary services, Ambulance services, Medico-legal sciences.

UNIT 3 HEALTH SYSTEM 12 Hrs. Health organization of the country, the state and cities, health financial system, teaching cum research hospitals, General Hospital, PHC reference system.

UNIT 4 HOSPITAL PLANNING 12 Hrs. Technical consideration, size & kind of hospitals, principles of planning, selection, site of orientation, equipment plan, communication and information system, Power supply, Air-conditioning, Water supply, elevators.

UNIT 5 NATIONAL HEALTH POLICY 12 Hrs. Need for evaluating a health policy, need for providing primary health care, Health education, health insurance, health legislation, inter sectoral cooperation.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Hans Pleiff veradammann (ed), Hospital Engineering in developing countries, GTZ report Eschborn, 1986. 2. R.C.Goyal, Human Resource Management in Hospitals, Prentice Hall of India, New Delhi, 2000. 3. M.A. George, The Hospital Administrator, Jaypee Publications, 2005. 4. Sanskriti Sharma, Essentials for Hospital Support Services and Physical Infrastructure Jaypee Publications, 2003.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 103 REGULATIONS 2015

SBM5608 HOSPITAL EQUIPMENT MAINTENANCE &

SAFETY

L T P Credits Total Marks 3 1 0 4 100

COURSE OBJECTIVE To train students and thus provide skilled technologists to the medical community. This course aims at giving a

through grounding in issues of safety for maintenance personnel working in medical establishments. The course will emphasize both the theoretical and practical parts.

UNIT 1 EQUIPMENT MANAGEMENT 12 Hrs. Organizing the maintenance operation, biomedical equipment procurement procedure, proper selection, compatibility, testing and installation, purchase and contract procedure, trained medical staff, on proper use of equipment and operating instructions. Maintenance job planning, preventive maintenance, maintenance budgeting, contract maintenance.

UNIT 2 LOGISTIC SUPPORT & RELIABILITY 12 Hrs. Maintenance equipment and Tools, failure analysis, spare parts and maintenance materials. Reliability fundamentals.

UNIT 3 ELECTROMAGNETIC INTERFERENCE IN HOSPITALS 12 Hrs. Principles of EMI, computation of EMI, Method of suppressing and isolating the unit from interference.

UNIT 4 HOSPITAL SAFETY 12 Hrs. Radiation safety, Safety precautions, Hazardous effects of radiation, allowed levels of radiation, ICRP regulations for radiation safety.

UNIT 5 ELECTRICAL & FIRE SAFETY 12 Hrs. Sources of shocks, macro & micro shocks, monitoring and interrupting the Operation from leakage current - Elements of fire, causes of fire & fire protection.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. Antony Kelly, Maintenance Planning & Control Butterworth, London, 1984. 2. Hans Pleiff veradammann (ed), Hospital Engineering in developing countries, GTZ report Eschborn, 1986. 3. Cesar A. Cacere & Albert Zana, The Practice of Clinical Engg, Academic press, Newyork, 1977. 4. Webster J.G and Albert M.Cook, Clinical Engg, Principles & Practices, Prentic Hall Inc., Engle wood Cliffs, New Jersy, 1979. 5. B.M.Sakharkar, Principles of Hospital administration and Planning, , Jaypee Brothers, Medical Publishers (P) Ltd. 1st edition

2007.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 104 REGULATIONS 2015

SBM5609 FIBER OPTICS & LASER FOR BIOMEDICAL APPLICATIONS

L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE This course introduces fundamental physical principles of both classical and modern optics as well as principles

of optical design used in the engineering of optical systems. It also provides exposure to practical aspects of optical materials and devices. Its intention is to provide a foundation of basic principles, design methodology, and practical considerations needed to design or use optical instruments in the biomedical engineering practice.

UNIT 1 INTRODUCTION 12 Hrs. Principles of light propagation through a fiber – fiber material - construction details of optical fiber - types of fibers – Absorption losses – Scattering losses – Dispersion

UNIT 2 OPTICAL SOURCES, DETECTORS, FIBER COUPLERS & CONNECTORS 12 Hrs. Optical Sources and Detectors: Introduction, LED’s, LASER diodes, Photo detectors – PIN photo diode, avalanche photo diode. Fiber Couplers and Connectors: Introduction, fiber alignment and joint loss, fiber splices, fiber connectors and fiber couplers- T-coupler, star coupler

UNIT 3 LASER CHARACTERISTICS & LASER IN BIOLOGY 12 Hrs. Laser Characteristics: Single frequency operation, coherence of laser, spatial distribution, intensity of laser emission, polarization of laser emission, measurement of pulsed laser energy. Laser In Biology: Optical properties of tissue, Pathology of laser reaction in skin, thermal effects, laser irradiation, Non thermal reactions of laser energy in tissue.

UNIT 4 LASER INSTRUMENTATION 12 Hrs. Surgical instrumentation of CO2, Ruby, Nd-YAG, He-Ne, Argon ion, Q-switched operations, continuous wave, Quasi – continuous, surgical applications of these lasers

UNIT 5 HOLOGRAM AND MEDICAL APPLICATIONS 12 Hrs. Holography – Basic principle - Methods – Holographic interferometry and application, Holography for non-destructive testing – Holographic components – Medical applications of lasers- Dermatology, dentistry, ophthalmology.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. G. Keiser, Optical Fiber Communication, McGraw Hill, 1995. 2. M. Arumugam, Optical Fiber Communication and Sensors, Anuradha Agencies, 2002. 3. Leon Goldman, The Biomedical laser Technology and Clinical Applications , Springer-Verlag, 1981. 4. Leon Goldman, Lasers in Medicine, Springer-Verlag,1982 5. Monte Ross, Laser Applications, McGraw Hill, 1971.

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 105 REGULATIONS 2015

SBM5610 MEDICAL ELECTRONICS AND E-HEALTH L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVES To close the gap between theoretical concepts and realistic industry/research applications in the field of medical

electronics. To produce graduates who understand information technology and advanced telecommunications technology. To create an awareness of the increasing role and potential of information technology and advanced

telecommunications technology for effective and efficient health services, and to provide health professionals and others with the theoretical and practical knowledge which will enable them to take leading roles within the emerging field of Health Informatics.

UNIT 1 CHEMICAL AND OPTICAL TRANSDUCERS 12 Hrs. PH, PO2, PCO2, HCO3 electrodes, Ion sensor, Anion and Cation sensor, Liquid and solid ion exchange membrane electrode, Enzyme electrode, Principle of fiber optic cable, fiber optic sensors, Photo acoustic sensors, PPG sensors.

UNIT 2 DIGITAL BIOPOTENTIAL AMPLIFIER 12 Hrs. Basic Parameters of Biopotential Amplifier design; Half cell potential, Reference electrodes, polarization effects, Polarisable and non polarisable electrodes, Micro electrodes, Equivalent Circuits Simplified recording of biopotential; Low-Polarization surface electrodes; Single ended biopotential amplifiers; Ultrahigh impedance electrode buffer arrays; Pastless bioppotential electrodes.

UNIT 3 SIGNAL CONDITIONING AND MEDICAL SAFETY 12 Hrs. Signal Conditioning circuits- Characteristics of Amplifiers, Differential Amplifiers, Filters, Bridge circuits, A/D Converters. Medical Safety: Electromagnetic Interference Requirements; Transient Voltage protection; Sources of Conducted and radiated interference.

UNIT 4 TELEMEDICINE AND HEALTH 12 Hrs. History and Evolution of telemedicine, Functional diagram of telemedicine system, Tele health, Global and Indian scenario, Ethical and legal aspects of Telemedicine -Confidentiality, Social and legal issues, Safety and regulatory issues, Principles of Multimedia technology- Data communications and networks, Internet, LAN and WAN technology. Satellite communication, GSM satellite, Communication infrastructure for telemedicine, Video and audio conferencing. Data Security and Standards: Encryption, Cryptography. Protocols: TCP/IP, ISO- OSI, Standards to followed DICOM, HL7, H. 320 series (Video phone based ISBN) T. 120, H.324 (Video phone based PSTN), Video Conferencing, Real -time Telemedicine integrating doctors / Hospitals. Administration of centralized medical data, security and confidentially of medical records and access control, Cyber laws related to telemedicine.

UNIT 5 MOBILE TELEMEDICINE AND APPLICTION 12 Hrs. Tele radiology: Definition, Basic parts of teleradiology system: Image Acquisition system Display system, Tele pathology, multimedia databases, color images of sufficient resolution, Dynamic range, spatial resolution, compression methods, Interactive control of color, Medical information storage and management for telemedicine - patient information medical history, test reports, medical images diagnosis and treatment. Hospital information system - Doctors, paramedics, facilities available. Pharmaceutical information system. Introduction to robotics surgery, telesurgery. Telecardiology, Teleoncology, Telemedicine access to health education and self care.

Max. 60 Hours .TEXT / REFERENCE BOOKS 1. Reinaldo Perez, Design of Medical Electronic Device, Elsevier Science, 1st Edition.2002. 2. John G.Webster, Medical Instrumentation, Application and Design, Third Edition, John willey and sons,1999 3. Norris, A.C. Essentials of Telemedicine and Telecare. Wiley (ISBN 0-471-53151-0), 2002 4. Wootton, R., Craig, J., Patterson, V. (Eds.), Introduction to Telemedicine.Royal Society of Medicine Press Ltd (ISBN

1853156779), 2006 6. O’Carroll, P.W., Yasnoff, W.A., Ward, E., Ripp, L.H., Martin, E.L. (Eds), Public Health Informatics and Information Systems.

Springer (ISBN 0-387-95474-0), 2003 END SEMESTER EXAMINATION QUESTION PAPER PATTERN

Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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SATHYABAMA UNIVERSITY FACULTY OF BIO AND CHEMICAL ENGINEERING

M. E. / M. Tech REGULAR 106 REGULATIONS 2015

SBM5611 NEURAL NETWORKS AND FUZZY LOGIC

IN MEDICINE

L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECTIVE This program gives a comprehensive package in the area of fuzzy logic and neural network fundamentals with

applications ranging in the engineering field. This a concise bioinspired course will deal with and enable the student to underlying concepts and medical applications of Self-organizing maps, Genetic algorithm, Support Vector Machines.

UNIT 1 INTRODUCTION 12 Hrs. Neural network learning rules – Supervised and Unsupervised Learning, single layer networks – Perceptron-Linear seperability Single Layer and Multilayer Perception, Adaptive linear neuron (Adaline) and LMS algorithm - Error back propagation algorithm, generalized delta rule.

UNIT 2 SOM AND ART 12 Hrs. Counter propagation network -Training of Kohenen And Grossberg Layer-feature mapping, self organizing feature maps, Adaptive Resonance theory (ART) Network- ART1 and ART 2 Architecture

UNIT 3 GENETIC ALGORITHMS AND SVM 12 Hrs. Evolution, search spaces and fitness landscapes, Elements of Genetic Algorithms, Data structures, Adaptive Encoding. Selective Methods, Genetic operators, Fitness Scaling, GA applications

UNIT 4 FUZZY LOGIC SYSTEMS 12 Hrs. Introduction to fuzzy set theory –– membership function - basic concepts of fuzzy sets – Operations on fuzzy sets and relations, classical set Vs fuzzy set – properties of fuzzy set – fuzzy logic control principles – fuzzy relations – fuzzy rules – Defuzzification

UNIT 5 ADVANCES AND APPLICATIONS 12 Hrs. Evolving Support Vector Machine, Neural networks using GA, Applications of ANN in biomedical signal analysis and medical image analysis.

Max. 60 Hours

TEXT / REFERENCE BOOKS 1. James A. Freeman & David M. Skapura, Neural Networks Algorithms, Applications, and Programming Techniques, Pearson

Education 1991. 2. S. Haykin, Neural Networks: A Comprehensive Foundation, Pearson Education (Asia) Pte. Ltd/prentice Hall of India, 2003. 3. Timothy J.Ross, Fuzzy logic with Engineering Applications; McGraw Hill, 1997. 4. M.T.Hagan, H.B.Demuth and M.Beale, Neural Network Design, Thomson Learning, 2002. 5. Philip D.Wasermann, Advanced Methods in neural Computing, Van Nostrand Reinhold, New York 1993. 6. David Goldberg, Genetic Algorithms in Search, Optimization and machine learning, Addison – Wesley USA 1997. 7. Bart Kosko, Neural Networks and Fuzzy Systems. Prentice Hall of India, 2005 8. Melanie Mitchell, An Introduction to Genetic Algorithms: Prentice Hall of India, New Delhi 1998. 9. George J. Klir and Bo yaun, Fuzzy Logic: Theory and Application, Prentice Hall of India, 2001

END SEMESTER EXAMINATION QUESTION PAPER PATTERN Max. Marks : 80 Exam Duration : 3 Hrs. PART A : 6 Questions of 5 Marks each – No Choice 30 Marks PART B : 2 Questions from each unit of internal choice, carrying 10 Marks each 50 Marks

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