PROGRAM

3RD CIRP CONFERENCE ON BIOMANUFACTURING

Chicago, U.S.

July 11th – 14th, 2017

NORTHWESTERN INITIATIVE FOR MANUFACTURING SCIENCE AND INNOVATION

undertakes multi-disciplinary research and education initiatives associated with

manufacturing across the broad spectrum that impact both mass-production

manufacturing and emerging hyper-customized and personalized

manufacturing.

Northwestern NORTHWESTERN INITIATIVE FOR

MANUFACTURING SCIENCE AND INNOVATION

WHAT IS IT?

Manufacturing is the ideal platform that integrates discoveries from basic sciences, technological and

business innovation, and human-factors "design." Northwestern Initiative for Manufacturing Science and

Innovation (NIMSI) can both focus and leverage our strengths in manufacturing processes and equipment,

design, materials, nanotechnologies, computational tools, human-machine interface, logistics, policy

analysis, and serve to expand and encourage collaborations with multiple existing centers and affiliations of

Northwestern and external partners.

� FLEXIBLE AND� PERSONALIZED

MANUFACTURINGWe seek new solutions to meet

the ever-increasing demand on

rapid manufacturing and

hyper-individualized needs.

� COMPUTATIONAL� DESIGN AND

MANUFACTURINGWe address the complexity

and scalability of

manufacturing systems using

predictive digital tools across

length and time scales.

� LOGISTICS AND POLICY� ANALYSIS

We consider issues related to

supply chains, energy use,

sustainability, and economic

and employment policy.

DIRECTOR: Jian Cao, Associate VP for Research and Cardiss Collins Professor of Mechanical Engineering

CONSULTANT: Mark Mills, Faculty Fellow NU and Senior Fellow Manhattan Institute

WELCOME MESSAGE

We are pleased to welcome you to Chicago for the 3rd CIRP Conference on Biomanufacturing, 2017. Our event will

proudly host participants and perspectives from 18 different countries spanning North and South America, Australia,

Asia, and Europe, as well as 17 different States here in the U.S.

Biomanufacturing, defined as the design, fabrication, assembly and measurement of bio-elements into structures,

devices, and systems, and their interfacing and integration into/with larger scale structures in vivo or in vitro, is an

emergent domain integrating life sciences and engineering principles.

CIRP, the World Academy for Production Engineering, plays a key role in this area promoting multidisciplinary research

towards the development of medical and welfare devices and systems for improving quality of life and reducing global

healthcare costs.

The CIRP-Biomanufacturing conference was designed to be an international forum to discuss progress and future

directions, and revise milestones as necessary, to facilitate exchange of information on biodesign, biofabrication and

biomechatronics.

We want to express our appreciation to all participants, Plenary Speakers, members of the International Scientific

Committee, Session Chairs, Students, Sponsors and Administrative Assistants, for contributing to the success of this

Conference.

We hope that all of you feel rewarded for your participation and contribution.

Yours Sincerely,

Jian Cao (Conference Chair) Albert Shih (Scientific Chair)

Endorsed By:

Sponsored By:

CONFERENCE CHAIR SCIENTIFIC CHAIR

JIAN CAO NORTHWESTERN UNIVERSITY

ALBERT SHIH UNIVERSITY OF MICHIGAN

ADMINISTRATIVE SUPPORT

MAEGEN GREGORY ASST. to PROFESSOR CAO

NORTHWESTERN UNIVERSITY

DALIUS DUNCIA NIMSI NORTHWESTERN UNIVERSITY

YANG LIU ASST. to PROFESSOR SHIH

UNIVERSITY OF MICHIGAN

SCIENTIFIC COMMITTEE

A. MALSHE (USA)D. WILLIAMS (UK)P.J. BARTOLO (UK)G. BYRNE (IRELAND)E. CERETTI (ITALY)T.H.C. CHILDS (UK)D. DUMUR (FRANCE)A. FISCHER (ISRAEL)B. KARPUSCHEWSKI (GERMANY)F. KLOCKE (GERMANY)T. KURIBAYASHI (JAPAN)M. LEU (USA)

G. LEVY (ISRAEL)A. MALSHE (USA)T. MATSUMURA (JAPAN)M. MITSUISHI (JAPAN)H. OHMORI (JAPAN)K.P. RAJURKAR (USA)B.M. SCHUMACHER (SWITZERLAND)E. SHAMOTO (JAPAN)A. SHIH (CHAIR)L. SHU (CANADA)W. SUN (USA)C. SUN (USA)

LOCAL ORGANIZING COMMITTEE

J. CAO (USA)K. EHMANN (USA)C. SUN (USA)

Conference Venue Northwestern University, Arthur Rubloff Building, 375 E. Chicago Ave, Chicago, IL 60611

Welcome Reception and Registration Tuesday, July 11th, 5-7 pm Rubloff Building, Thorne Lobby

Join us for drinks, hors d’oeuvres and a casual welcome to start the week’s events. Just a 2-minute walk from the Cambria Hotel. Conference Registration available at this event.

Thorne Lobby Arthur Rubloff Building

375 E. Chicago Ave

Wi-Fi Access in Rubloff Building

Guest-Northwestern: A network available to all visitors. Enter your contact information and Jian Cao as the individual sponsoring your visit. Eduroam: Visitors from eduroam-enabled institutions should use the eduroam at Northwestern network.

Rubloff Building Room Map

Thorne Lobby Meals and Reception

RB140 Plenary Talks

RB175 & RB180 Paper Sessions

Meal seating available in Thorne Lobby and the additional labeled locations.

Contact Details To contact the event hosts, please dial (773) 620-9700 or email CIRPBioM2017@northwestern.edu

7:30 – 8:15 Registration & Breakfast Thorne Lobby, Rubloff Building

8:15 – 8:30 Welcome & Remarks Rubloff 140 (RB140)

Plenary Speakers Rubloff 140

8:30 – 9:15 3D Bioprinting of Vascularized Human Tissues Jennifer Lewis (Harvard University, U.S.)

9:15 – 10:00 Materials and Manufacturing Schemes for Bio-Integrated Electronics

John Rogers (Northwestern University, U.S.)

Coffee Break (10:00 – 10:30) Thorne Lobby

Session 1: Medical Device Rubloff 175

Session 2: Process Rubloff 180

Time Co-Chairs: Joaquim Ciurana, Chengyong Wang Co-Chairs: Robert C Chang, Jelena Ochs

10:30 – 10:55 Fabrication of PCL/PLA composite tube for stent manufacturing Antonio J Guerra; Joan San; Joaquim Ciurana

Invited: Nontraditional Machining for Medical Device Manufacturing Kamlakar Rajurkar

10:55 – 11:20 Suitability evaluation of various manufacturing technologies for the development of surgical snake-like manipulators from metals based on flexure hinges Suat Coemert; Mattias F Traeger; Eva C Graf; Tim C Lueth

The effect of cooling strategies and machining feed rate on the corrosion behavior and wettability of AZ31 alloy for biomedical applications Rachele Bertolini; Stefania Bruschi; Andrea Ghiott; Luca Pezzato; Manuele Dabalà

11:20 – 11:45 A review on surgical instruments of knee arthroscopic debridement and total hip arthroplasty Zhihua Chen; Chengyong Wang; Wentao Jiang; Na Tang; Bin Chen

Dimensional metrology of cell-matrix interactions in 3D microscale fibrous substrates Filippos Tourlomousis; Robert C Chang

11:45 – 12:10 A comparison review on orthopaedics surgery using piezosurgery and conventional tools Yue Zhang; Chengyong Wang; Zhihua Chen; Shaobo Zhou; Zhihua Liu; Linlin Xu

Parallelization in automated stem cell culture Michael Kulik; Jelena Ochs; Niels König; Christine McBeth; Alexis Sauer-Budge; Andre Sharon; Robert Schmitt

Lunch Break (12:10 – 1:10) Thorne Lobby

Session 3: Scaffold / Substrate Rubloff 175

Session 4: Biomechanics Rubloff 180

Time Co-Chairs: Paola Serena Ginestra, Elisabetta Ceretti

Co-Chairs: Nino Fabian Läubli, Michel Mesnard

1:10 – 1:35 Invited: Biopolymer Microfabrication for Tissue Engineering & Regenerative Medicine Leo Han

Study on mechanical response model of soft tissue in the clamping process Pengpeng WEI; Hongjian DONG; Yingqiang XU; Hongcai ZHANG; Qinhe Zhang

1:35 – 2:00 Multi-layered scaffolds production via Fused Deposition Modeling (FDM) using an open source 3D printer: process parameters optimization for dimensional accuracy and design reproducibility Elisabetta Ceretti; Paola Ginestra; Antonio Fiorentino; Jorge Da Silva; Paulo Neto

Force measurement of blood vessel gripping by hydraulic-driven forceps Tohru Sasaki; Masao Hebisawa; Yasuyuki Mito; Kuniaki Dohda; Satoshi Kuroda

Day 1 - Wednesday, July 12th

2:00 – 2:25 Micro-structuring of titanium collectors by laser ablation technique: a novel approach to produce micro-patterned scaffold for tissue engineering applications Paola Serena Ginestra; Antonio Fiorentino; Elisabetta Ceretti

Controlled three-dimensional rotation of single cells using acoustic waves Nino Fabian Läubli; Naveen Shamsudhin; Daniel Ahmed; Bradley J Nelson

2:25 – 2:50 3D bioprinting of solvent dissolved biopolymer/glass composite and stem cell-laden Hydrogel for tissue engineering Krishna Kolan; Jakeb Baldridge; Yong Liu; Caroline Murphy; Julie A Semon; Delbert E Day; Ming C Leu

Optimizing the architecture of a dynamic spinal implant for customized mechanical behavior Yann LEDOUX; Antonio RAMOS; Michel MESNARD

Coffee Break (2:50 – 3:20) Thorne Lobby

Session 5: Additive Manufacturing Rubloff 175

Session 6: Medical Device Rubloff 180Rubloff 175 Rubloff 180 Rubloff 180Time Co-Chairs: Rory Gibney, Erica Liverani Co-Chairs: William Loewenhardt, Deema Totah

3:20 – 3:45 Corrosion resistance and mechanical characterization of ankle prostheses fabricated via SLM Erica Liverani; Andrea Balbo; Alessandro Fortunato; Cecilia Monticelli; Alberto Leardini; Claudio Belvedere

Invited: Activity-based synthetic biomarkers that predict the onset of organ transplant rejection Gabe A Kwong

3:45 – 4:10 Modeling and additive manufacturing of biomimetic heterogeneous structures Navid Khani; Sameer Khale; Ali Nadernezhad; Bahattin Koc

Image Processing for Autonomous Positioning of Eye Surgery Robot in Micro-Cannulation Takashi Tayama; Yusuke Kurose; Tatsuya Nitta; Kanako Harada; Yusei Someya; Seiji Omata; Fumihito Arai; Fumiyuki Araki; Kiyoto Totsuka; Takashi Ueta; Yasuo Noda; Muneyuki Takao; Makoto Aihara; Naohiko Sugita; Mamoru Mitsuishi

4:10 – 4:35 The human cornea as a model tissue for additive biomanufacturing: a review Rory Gibney; Steffi Matthyssen; Jennifer Patterson;Eleonora Ferraris; Nadia Zakaria

Toward autonomous collision avoidance for robotic neurosurgery in deep and narrow spaces in the brain Hiroaki Ueda; Ryoya Suzuki; Atsushi Nakazawa; Yusuke Kurose; Murilo M Marinho, Master; Naoyuki Shono; Hirofumi Nakatomi; Nobuhito Saito; Akio Morita; Eiju Watanabe; Kanako Harada; Naohiko Sugita; Mamoru Mitsuishi

4:35 – 5:00 Systematic Biomimetic Part Design for Additive Manufacturing Tobias Kamps; Melanie Gralow; Georg Schlick; Gunther Reinhart

Integrating cell sheets for organ-on-a-chip applications William Loewenhardt; Brian Derby; Rachel Lennon; Rachel Saunders

5:00 – 5:25 Fabrication speed optimization for high-resolution 3D-printing of bioresorbable vascular stents Henry Oliver T. Ware; Adam C Farsheed; Evan Baker; Guillermo Ameer; Cheng Sun

Manufacturing Choices for Ankle-Foot Orthoses: A Multi-objective Optimization Deema Totah; Ilya Kovalenko; Miguel Saez; Kira Barton

Day 1 - Wednesday, July 12th

7:30 – 8:15 Registration & Breakfast Thorne Lobby, Rubloff Building

8:15 – 8:30 Welcome & Remarks Rubloff 140 (RB140)

Plenary Speakers Rubloff 140

8:30 – 9:15 Metrology in Bio-Applications Xiang (Jane) Jiang (University of Huddersfield, UK)

9:15 – 10:00 Programming the Formation of Optically-Active Colloidal Crystals with DNA

Chad Mirkin (Northwestern University, U.S.)

Coffee Break (10:00 – 10:30) Thorne Lobby

Session 7: Scaffold / Substrate Rubloff 175

Session 8: Additive Manufacturing Rubloff 180

Time Co-Chairs: Yancheng Wang, Roland K Chen Co-Chairs: Giedon Levy, Henry Oliver T. Ware

10:30 – 10:55 A study on degradation behavior of 3D printed gellan gum scaffolds Ilhan Yu; Samantha M Kaonis; Roland K Chen

Invited: Bioprinting: Implementation, Process Dynamics, and Process‐Induced Cell Injury Yong Huang

10:55 – 11:20 Electrospinning parameters selection to manufacture polycaprolactone scaffolds for three-dimensional breast cancer cell culture and enrichment Marc Rabionet; Teresa Puig; Joaquim Ciurana

Invited: 3D Printing Functional Materials & Devices Michael McAlpine

11:20 – 11:45 Trabecular scaffolds´ mechanical properties of bone reconstruction using biomimetic implants Carlos Gabriel Helguero Alcivar; Jorge L Amaya; David E Komatsu; Srinivas Pentyala; Vamiq Mustahsan; Emilio A Ramirez; Imin Kao

Methodology for Image-driven High-resolution Additive Manufacturing Using Discretized Data Set Henry Oliver T. Ware; Wenzhong Liu; Jianmin Hu; Hao Zhang; Cheng Sun

11:45 – 12:10 Fabrication of Micro-wavy Patterned Surfaces for Enhanced Cell Culturing Yancheng Wang; Zongkai Yu; Deqing Mei; Dai Xue

Process chain for the fabrication of a custom 3D barrier for guided bone regeneration Erick Ramirez-Cedillo; Hernan Lara-Padilla; Luis F Zamudio-Pena; Aida Rodriguez-Garcia; Leopoldo Ruiz-Huerta; Alberto Caballero-Ruiz; Hector R. Siller

Lunch Break (12:10 – 1:10) Thorne Lobby

Session 9: Medical Device Rubloff 175

Session 10: Additive Manufacturing Rubloff 180Rubloff 175 Rubloff 180

Time Co-Chairs: Scott Miller, Alexis F. Sauer-Budge Co-Chairs: Xiaoqing Tian, Bahattin Koc

1:10 – 1:35 Invited: Vibration-assisted slicing of soft tissue for biopsy procedures Marco Giovannini

The development of an all-polymer based piezoelectric photocurable resin for additive manufacturing Xiangfan Chen; Henry O Ware; Evan Baker; Weishen Chu; Jianmin Hu; Cheng Sun

1:35 – 2:00 Workcell for Hybrid Medical Device Fabrication Nicholas Ho; Wilson Ang; Chee-Kong Chui

Biaxial Testing of Silicone Fabric Made Through Additive Manufacturing Ketut Putra; Jeff Plott; Albert Shih

2:00 – 2:25 Electromagnetic suspension system for control of limb volume in prosthetics Jarrod Ng; Jedediah Johnson; Scott Miller; Kai Newton; Tim Roe; Russell Woo

Silicone Foam Additive Manufacturing by Liquid Rope Coiling Xiaoqing Tian; Jeffery Plott; Hongjun Wang; Bizhong Zhu; Albert Shih

Day 2 - Thursday, July 13th

2:25 – 2:50 Automated tissue dissociation for rapid extraction of viable cells Christine McBeth; Angela Gutermuth; Jelena Ochs; Andre Sharon; Alexis Sauer-Budge

Biomanufacturing of heterogeneous hydrogel structures with patterned electrically conductive regions Ali Nadernezhad; Navid Khani; Bahattin Koc

Coffee Break (2:50 – 3:20) Thorne Lobby

Session 11: Process Session 12: Biomechanics

Rubloff 175 Rubloff 180

Time Co-Chairs: Sarah Busemann, Dian-Ru Li Co-Chairs: Wei Li, Ling Yin

3:20 – 3:45 Optical Measurement of Tissue Deformation in Needle Insertion Dian-Ru Li; Jih-Kai Yeh; Ketut Putra; Albert Shih

Process parameter optimization for hot embossing uniformly textured UHMWPE surfaces for orthopedic bearings Christina Ippolito; Sufujiang Yu; Yong Jun Lai; Tim Bryant

3:45 – 4:10 Impact of hard machining on surface and subsurface properties of zirconia based ceramics for dental applications Berend Denkena; Bernd Breidenstein; Sarah Busemann; Claudius Moritz Lehr

Topology Optimization to reduce the stress shielding effect for orthopedic applications Abdulsalam Altamimi; Paulo Fernandes; Chris Peach; Akso Cseke; Paulo Bartolo

4:10 – 4:35 Material Removal Mechanisms in Grinding of Mixed Oxide Ceramics Berend Denkena; Sarah Busemann; Lukas Gottwik; Thilo Grove; Andi Wippermann

A review of engineered zirconia surfaces in biomedical applications Ling Yin; Yoshitaka Nakanishi; AbdurRasheed Alao; Xiao-Fei Song; Jaafar Abduo; Yu Zhang

4:35 – 5:00 Image-guided Quality Control of Biomanufacturing Process Chen Kan; Ruimin Chen; Hui Yang

Invited: Solvent-free Fabrication of Engineered Tissue Model SystemsWei Li

Dinner Cruise 6-9 pm, Anita Dee II, 200 N Breakwater Access, Chicago, IL 60601*Join us for an Architectural Tour, Dinner Cruise along the beautiful Chicago Lakefront. Casual Attire

Boat Departs dock at 6 pm sharp. *The dock does not have an actual address. If traveling to the boat in your own

car or taxi, please confirm the location with staff before departing.

BE SURE TO NOTIFY EVENT STAFF IF YOU ARE ATTENDING THE CRUISE,ALLOWING US TO CONFIRM EVERYONE IS ONBOARD BEFORE DEPARTURE.

GETTING TO THE DOCK FREE SHUTTLE: Shuttle from Cambria Hotel to boat dock at 5:30

pm and 5:45 pm, returning to hotel at 9:00 pm and 9:15 pm.

WALKING: Guests are welcome to walk to the boat dock. It is a20-minute walk from the Venue or Cambria Hotel. See map ->

Day 2 - Thursday, July 13th

Walking to Boat, Fairbanks into Columbus, Downstairs to S. Riverwalk, cross under Lakeshore Dr.

7:45 – 8:30 Registration & Breakfast Thorne Lobby, Rubloff Building Plenary Speaker Rubloff 140

8:30 – 9:15 Micro-Nano Robotics for Biomedical R&D Fumihito Arai (Nagoya University, Japan)

Coffee Break (9:15 – 9:45) Thorne Lobby

Session 13: Scaffold / Substrate Rubloff 175

Session 14: Process Rubloff 180

Time Co-Chairs: Binil Starly, Yang Liu Co-Chairs: Bruce L. Tai, Ciro Angel Rodriguez

9:45 – 10:10 Human Mesenchymal Stem Cells Expansion on Three-Dimensional (3D) Printed Poly-Styrene Scaffolds in a Perfusion Bioreactor Arun Kumar; Wing Lau; Binil Starly

Invited: Skin friction drag reduction over a micro-patterned superhydrophobic surface in turbulent boundary flow Bingfu Zhang

10:10 – 10:35 Polycaprolactone/Pluronic F127 tissue engineering scaffolds via electrohydrodynamic jetting for gastro intestinal repair Bin Wu; Yang Wu; Weng Feng Lu; Jerry Y. H. Fuh

Invited: Nanoscale Metrology in Molecular Manufacturing: Approaches to Overcome Current Challenges Mostafa Bedewy

10:35 – 11:00 Invited: Computational Fluid Dynamics Modelling of Rotational AtherectomyYang Liu

Electrospinning Complexly-shaped, Resorbable, Bifurcated Vascular Grafts Raquel Tejeda-Alejandre; Hernan V. Lara-Padilla; Christian Mendoza-Buenrostro; David Dean; Ciro Angel Rodriguez

11:00 – 11:25 Production of micro-patterned substrates to direct iPSCs-derived neural stem cells orientation and interaction Rosalba Monica Ferraro; Paola S Ginestra; Gaetana Lanzi; Silvia Giliani; Elisabetta

A feasibility study of laser-assisted titanium implant drilling for periprosthetic fracture repair Carleton T Vangsness; Bruce Li-Jung Tai

11:25 – 11:50 High-resolution 3D bioprinting system for fabricating cell-laden hydrogel scaffolds with high cellular activities Bin Zhang; Lei Gao; Long Gu; Huayong Yang; Yichen Luo; Liang Ma

Lunch (11:50 – 1:00) Thorne Lobby

Day 3 - Friday, July 14th