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PROGRAM AND ABSTRACT BOOK2nd Retreat

Center for Pathophysiology, Infectiology and Immunology

Tuesday, September 27, 2011 Lecture Hall of

Bernhard Gottlieb University Clinic of Dentistry

Sensengasse 2a | 1090 Wien

Center for Pathophysiology, Infectiology and Immunology

!Tuesday, September 16th, 2014 Lecture Hall Bernhard Gottlieb University

Clinic of Dentistry Sensengasse 2a, 1090 Vienna

Wednesday, September 17th, 2014

Seminar room, 1. floor Vienna Competence Center

Lazarettgasse 19, 1090 Vienna !

5th RETREAT – PROGRAM


PROGRAM Tuesday, September 16th, 2014 Bernhard Gottlieb University Clinic of Dentistry, Sensengasse 2a, Vienna IX 08.15 – 09.00 Poster Mounting 09.00 – 09.25 Opening Session

The Center for Pathophysiology, Infectiology and Immunology: Recent achievements, current status, future developments Hannes Stockinger

09.25 – 10.30 Activities of the Center in the health sector Chairperson: Ursula Wiedermann 09.25 – 09.35 Allergy diagnosis based on microarrayed allergens: the allergen chip Susanne Vrtala 09.35 – 09.45 Diagnosis of autoimmune diseases Gerhard Zlabinger 09.45 – 09.55 Immunophenotyping for diagnosis of immunodeficiencies and hematological malignancies Winfried Pickl 09.55 – 10.05 Laboratory support in the diagnosis of infectious diseases / quality of food Gerold Stanek 10.05 – 10.15 API Hygiene Wien: Water Hygiene and Medical-technical Hygiene is our mission Regina Sommer 10.15 – 10.30 The diagnostic goals of the ISPTM Herbert Auer 10.30 – 11.30 Running slides part 1 (short presentations: SP1 – SP20) Chairperson: Andreas Müller

2-minutes introduction of the poster and presentation of take-home message by the presenting author

11.30 – 12.00 Coffee Break 12.00 - 13.00 Running slides part 2 (short presentations: SP21 – SP40) Chairperson: Ute Scheikl 2-minutes introduction of the poster and presentation of take-home message by the presenting author 13.00 – 13.30 Lunch

13.30 – 14.30 Poster Workshops 1 -

Responsible authors present their posters at the poster site Workshop 1 (SP01 – SP10) Chairpersons: Wilfried Ellmeier, Aleksandra Inic Workshop 2 (SP11 – SP20) Chairpersons: Herbert Auer, Nicole Boucheron Workshop 3 (SP21 – SP30) Chairpersons: Julia Walochnik, Gerhard Zlabinger Workshop 4 (SP31 – SP40) Chairpersons: Margit Focke-Tejkl, Shinya Sakaguchi

5th RETREAT – PROGRAM


14.30 – 16.00 Running slides part 3 (short presentations: SP41– SP78) Chairperson: Jacqueline Montanaro-Punzengruber 2-minutes introduction of the poster and presentation of take-home message by the presenting author

16.00 – 16.15 Coffee break 16.15- 17.15 Poster Workshops Responsible authors present their posters at the poster site

Workshop 5 (SP41 – SP50) Chairpersons: Sabine Flicker, Gerold Stanek Workshop 6 (SP51 – SP60) Chairpersons: Regina Sommer, Peter Steinberger Workshop 7 (SP61 – SP69) Chairpersons: Erika Garner-Spitzer, Johannes Stöckl Workshop 8 (SP70 – SP78) Chairpersons: Michael Duchene, Anna Repic

17.15 – 18.15 Keynote Lecture Chairpersons: Judith Leitner, Hannes Stockinger Inflammation and Cancer Alberto Mantovani, Università degli Studi di Milano, Scientific Director Istituto Clinico Humanitas, Italy, and President-elect of the International Union of Immunological Societies (IUIS)

19.00 Social Evening including Prize Ceremony of Short Presentations

Restaurant Culinarium, Währinger Straße 21, Vienna IX Wednesday, September 17th, 2014 Vienna Competence Centre, Lazarettgasse 19, Vienna IX, seminar room, 1. floor 13.00 Keynote Lecture

Chairperson: Winfried Pickl

Pathology of human type 1 and 2 diabetes and new immunotherapies Matthias von Herrath, Professor at the La Jolla Institute for Allergy and Immunology, California, USA

We also would like to draw your attention to the immunological sessions at the Annual Meeting of the Austrian Association of Molecular Life Sciences and Biotechnology!http://www.oegmbt.at/jahrestagung/programm: Wednesday, September 17, 2014, 10.15 am. Admission upon registration till Monday September 15, 03.00 pm with Petra Eisenhut. First-in-class inhibitor of upstream TCR signaling for the treatment of autoimmune diseases Balbino Alarcon, Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Spain. Thursday, September 18, 2014, 10.15 am. Admission by the code CePII at the registration desk. Motility and stability in T cell priming Antonella Viola, Istituto Clinico Humanitas - University of Milan, Italy Functional heterogeneity of macrophage and dendritic cell subsets Herbert Strobl, Institute of Pathophysiology and Immunology, Medical University Graz, Austria

5th RETREAT – WORKSHOPS


WORKSHOPS



WORKSHOP 1 (SP01 – SP10) Chairpersons: Wilfried Ellmeier, Aleksandra Inic-Kanada THE UROKINASE RECEPTOR AS A POSITIVE REGULATOR OF T CELL ACTIVATION Alexander Zwirzitz1, Karin Pfisterer1, Vladimir Leksa1,2 and Hannes Stockinger1 PERINATAL INTERVENTIONS WITH PROBIOTIC BACTERIA FOR THE PREVENTION OF AIRWAY INFLAMMATION IN MICE Christian Zwicker1, Melanie R. Hassler2, Gerda Egger2, Anja Joachim3, Ursula Wiedermann1, Irma Schabussova1

NATURAL CLINICAL TOLERANCE TO PEANUT IN AFRICAN PATIENTS IS CAUSED BY POOR ALLERGENIC ACTIVITY OF PEANUT IgE 1Eva Wollmann, 2,3 Carl Hamsten, 4Elopy Sibanda, 1Mary Ochome, 1Margarethe Focke-Tejkl, 2,5Anna Asarnoj, 6Annika Önell, 7Gunnar Lilja, 1Daniela Gallerano, 1Christian Lupinek, 8Theresa Thalhamer, 8Richard Weiss, 8Josef Thalhamer, 7,9Magnus Wickman, 1Rudolf Valenta, and 2Marianne van Hage

IMMUNOMODULATION OF ALLERGIC IMMUNE RESPONSES BY ANTIGEN EXTRACTS DERIVED FROM TOXOPLASMA GONDII OOCYSTS Angelika Wagner¹, Irma Schabussova¹, Mirjana Drinic¹, Johnnie Akgün¹, Bärbel Ruttkowski2, Anja Joachim2, Ursula Wiedermann1,3

BABESIOSIS IN AUSTRIA Thomas Strebinger, Iveta Häfeli, Herbert Auer, Albin Obiltschnig, Horst Aspöck, Julia Walochnik CTL TARGET RECOGNITION, A MOLECULAR IMAGING APPROACH Paul Spechtl, René Platzer and Johannes Huppa ANTI-CANCER ACTIVITY EVALUATION AND QUALITY CONTROL OF PANAX QUINQUEFOLIUS SAPONINS Shan He1, Teresa Manhardt1, Mei Xue2, Dazhuo Shi2, Lu Liu3, Christian Radauer1, Heimo Breiteneder1, Enikö Kallay1, Yan Ma1

MELATONIN AS AN ANTI-HYPERTENSIVE COMPOUND? EXPRESSION OF MELATONIN RECEPTOR TYPE 1 IN PERIVACULAR FAT TISSUE OF MESENTERIC ARTERIES!Arife Sener1, Andreas Maier1, Lena Kuhn1, Bernhard Seidelmann1, Maximilian Huber1, Hana Uher1, Lubos Molcan2, Michal Zeman2, Isabella Ellinger1

VBNC LEGIONELLAE - TRANSITION FROM CULTURABLE TO THE VIABLE BUT NON CULTURABLE STATE BY STARVATION Barbara Schrammel1, Sabrina Smelik1, Elisabeth Dietersdorfer2, Markus Petzold3, Christian Lück3, Regina Sommer1, Julia Walochnik2 & Alexander Kirschner1 THE REVERSE LINE BLOT FOR BORRELIA DETECTION AND DISCRIMINATION OF DIFFERENT BORRELIA GENOSPECIES Anna-Margarita Schötta, Michael Reiter, Andreas Müller, Hannes Stockinger and Gerold Stanek



WORKSHOP 2 (SP11 – SP20) Chairpersons: Herbert Auer, Nicole Boucheron CONSTITUTIVELY ACTIVE STAT3 GOVERNS GRANZYME B AND IL-10 PRODUCTION IN HUMAN CD4+ T-CELLS Klaus G. Schmetterer, Alina Neunkirchner, Daniela Wojta-Stremayr, Judith Leitner, Peter Steinberger and Winfried F. Pickl FREE-LIVING AMOEBAE (FLA) AND THEIR INTRACELLULAR BACTERIA IN AUSTRIAN COOLING TOWERS AND TAP WATERS Ute Scheikl1, Allen Tsao2, Matthias Horn2, Alexander Indra3 and Julia Walochnik1 RAPID MULTIPLEX ANALYSIS OF LIPID RAFTS WITH SINGLE CELL RESOLUTION Philipp Schatzlmaier, Johannes B. Huppa, Hannes Stockinger IMAGING ANTIGEN RECOGNITION OF HUMAN T-CELLS IN HELTH AND DISEASE Lydia Scharf, Sebastian Königsberger, Tamara Stary, Johannes Huppa NEONATAL COLONIZATION WITH RECOMBINANT LACTIC ACID BACTERIA FOR PREVENTION OF POLY-SENSITIZATION Priya Sarate1, Stefan Heinl2,!Hanka Kozáková3, Irma Schabussova1, Ursula Wiedermann1

CHARACTERIZATION OF THE CD8+ T CELL RESPONSE TO ALLERGENS Samadi N, Kitzmann C, Bohle B, Geyeregger R, Jahn Schmid B TRANSCRIPTIONAL CONTROL OF CYTOTOXIC T CELL DEVELOPMENT BY THE MAZR/RUNX COMPLEX Shinya Sakaguchi (1), Daniela Hainberger (1), Hirokazu Tanaka (2), Caroline Tizian (1), Lena Müller (1), Kseniya Khamina (3), Tsukasa Okuda (4), Yoram Groner (5), Andreas Bergthaler (3), Ichiro Taniuchi (2), Wilfried Ellmeier (1) ANALYSIS OF THE IgE- AND IgG-REACTIVITY PROFILES OF ASTHMATIC AND NON-ASTHMATIC HDM-ALLERGIC PATIENTS USING THE ISAC MICROARRAY SYSTEM Yvonne Resch,a Sven Michelb Michael Kabesch,b Rudolf Valenta,a Susanne Vrtalaa,c PRODUCTION OF RECOMBINANT MONO- AND BISPECIFIC ANTIBODY FRAGMENTS IN THE METHYLOTROPHIC YEAST PICHIA PASTORIS Srdjan Janjusic, Hannes Stockinger, Anna Repic DETECTION OF B. MIYAMOTOI IN IXODES RICINUS TICKS COLLECTED IN AUSTRIA Michael Reitera, Anna M. Schöttaa, Andreas Müllera, Franc Strleb, Eva Ruzic-Sabljicc, Hannes Stockingera and Gerold Staneka



WORKSHOP 3 (SP21 – SP30) Chairpersons: Julia Walochnik, Gerhard Zlabinger THE SOLUBLE CYTOPLASMIC TAIL OF CD45 (CT-CD45) INDUCES QUIESCENT ANERGY IN HUMAN T CELLS Alexander Puck, Maria Seyerl, Stefan Hopf, Otto Majdic, Gerhard Zlabinger, Judith Leitner, Peter Steinberger, Johannes Stöckl THE RESPONSE TO VEMURAFENIB IN V600 MUTANT MELANOMA CELLS IS MODIFIED BY HYPOXIA Daniela Pucciarelli1, Nina Lengger1, Martina Takáčová2, Lucia Csaderova2, Heimo Breiteneder1, Silvia Pastorekova2, Christine Hafner1,3

THE ROLE OF HDAC2 IN CD4+ EFFECTOR T CELLS Teresa Preglej1, Lisa Göschl1,2, Liisa Andersen1, Patrick Mathias3, Christian Seiser4, Wilfried Ellmeier1

THE ROLE OF NEUTROPHILS IN IGE-MEDIATED ALLERGY Dominika Polak, Birgit Nagl, Claudia Kitzmüller, Barbara Bohle

HOW T HELPER CELLS RECOGNIZE ANTIGEN ON PROFESSIONAL ANTIGEN PRESENTING CELLS; A MOLECULAR IMAGING APPROACH René Platzer‡, Mario Brameshuber*, Gerhard J. Schütz*, Hannes Stockinger‡ and Johannes B. Huppa‡

CD222 REGULATES THE TURN-OVER OF CD28 Karin Pfisterer, Maximilian Resch, Hannes Stockinger, and Vladimir Leksa THE INFLUENCE OF FOOD PROTEIN NITRATION ON THE ANAPHYLACTIC RESPONSE IN A MURINE FOOD ALLERGY MODEL Susanne C. Diesner (1,2), Cornelia Schultz (1), Chloé Ackaert (3), Gertie Janneke Oostingh (4), Anna Ondracek (1), Caroline Stremnitzer (1), Denise Heiden (1), Josef Singer (1), Franziska Roth-Walter (1,5), Judit Fazekas (1), Thomas Eiwegger (2), Zsolt Szépfalusi (2), Erika Jensen-Jarolim (1,5), Ernst-Hanno Stutz (3), Albert Duschl (3) and Eva Untersmayr (1) SEROPREVALENCE AND ASYMPTOMATIC CARRIAGE OF LEISHMANIA SPP. IN AUSTRIAN SOLDIERS RETURNING FROM MISSIONS IN THE LEBANON, SYRIA AND BOSNIA Adelheid G. Obwaller1,6, Wolfgang Poeppl2, Andrea Graf-Langheinz3, Gerhard Mooseder4, Angelus Faas5, Julia Walochnik6 RHINOVIRUS-INDUCED VP1-SPECIFIC ANTIBODIES ARE GROUP-SPECIFIC AND ASSOCIATED WITH SEVERITY OF RESPIRATORY SYMPTOMS 1Katarzyna Niespodziana, 1Clarissa R. Cabauatan, 2,3David J. Jackson, 1Daniela Gallerano, 2,3Belen Trujillo-Torralbo, 2,3Ajerico del Rosario, 2,3Patrick Mallia, 1Rudolf Valenta and 2,3Sebastian L. Johnston T REGULATORY CELLS INDUCED BY INTERLEUKIN-2/ANTI-INTERLEUKIN-2 MONOCLONAL ANTIBODY COMPLEXES IN VIVO REDUCE AIRWAY HYPERREACTIVITY IN HUMANIZED ALLERGY MICE Alina Neunkirchner1,2, Daniela Wojta-Stremayr1,2, Klaus G. Schmetterer2, Lukas Mager2 Victoria Reichl1,2, Edward Rosloniec3, Ronald Naumann4, Gerhard Dekan5, Beatrice Jahn-Schmid6, Barbara Bohle1,6 and Winfried F. Pickl1,2



WORKSHOP 4 (SP31 – SP40) Chairpersons: Margarete Focke-Tejkl, Shinya Sakaguchi NCOR1 FUNCTION IN T CELL DEVELOPMENT AND HOMEOSTASIS Müller, L. (1), Hassan, H. (1), Villunger, A. (2), Auwerx, J. (3), Ellmeier, W. (1) DEVELOPMENT OF THE FIRST DEFINED LIQUID MEDIUM FOR BARTONELLA Andreas Müller, Katrin Mantlik, Michael Reiter, Anna-Margarita Schötta, Hannes Stockinger and Gerold Stanek ACANTHAMOEBA – POSSIBLE HOST FOR BURKHOLDERIA PSEUDOMALLEI Verena Mündler1, Iveta Häfeli1, Ivo Steinmetz2, Julia Walochnik1

PRESERVING ULTRASTRUCTURE AND MORPHOLOGY OF TISSUE UNDER LABORATORY AND FIELD CONDITIONS USING PHEM BUFFERED FIXATIVES Jacqueline Montanaro1* and Nikolaus Leisch2, Daniela Gruber3, Aleksandra Inic-Kanada1, Sandra Belij1, Elisabeth Stein1, Nora Bintner1, Angela Ladurner1, Talin Barisani-Asenbauer1 BIDIRECTIONAL POLARIZATION OF T CELL FUNCTION VIA CD43 Madhura Modak, Petra Cejka, Petra Waidhofer-Söllner, Otto Majdic, Peter Steinberger, Gerhard Zlabinger, Johannes Stöckl SPHINGOLIPID-RELATED MULTIGENE SIGNATURE IMPROVES RISK PREDICTION FOR PATIENTS WITH PRIMARY OVARIAN CARCINOMA Anastasia Meshcheryakova1, Martin Svoboda1, Georg Heinze2, Erika Bajna1, Dietmar Pils3, Dan Tong3, Peter Birner4, Robert Zeillinger3, Diana Mechtcheriakova1 CHRONIC OLIGOARTHRITIS CAUSED BY BORRELIA BAVARIENSIS IDENTIFIED BY PCR FROM SYNOVIAL FLUID OF KNEE AND ANKLE JOINTS Mateusz Markowicz1, Stefan Ladstätter2, Anna Schötta1, Michael Reiter1, Gerald Pomberger2, Gerold Stanek1 AN EXTENSIVE MICROBIOLOGICAL SCREENING OF ORGANIC MEAT, RAW MILK, AND CEREAL PRODUCTS SAMPLED FROM VIENNESE ORGANIC SUPERMARKETS M. Manafi, Stephanie Müller DECIPHERING THE FUNCTION OF FOLATE RECEPTOR BETA Christian Machacek, Verena Supper, Goran Mitulović, Hana Tichovska, Hannes Stockinger and Anna Repic PLASMINOGEN SYSTEM IN APOPTOSIS AND EFFEROCYTOSIS Alexander Zwirzitz, Anna Ohradanova-Repic, Karin Pfisterer, Clemens Donner, Christian Machacek, Florian Forster, Verena Supper, Otto Majdic¶, Hannes Stockinger and Vladimir Leksa



WORKSHOP 5 (SP41 – SP50) Chairpersons: Sabine Flicker, Gerold Stanek THE CD2 - CD58 AXIS IS THE PRIMARY COSTIMULATORY PATHWAY IN HUMAN CD28 NEGATIVE CD8 T CELLS Judith Leitner*, Dietmar Herndler-Brandstätter**, Beatrix Grubeck-Loebenstein**, Gerhard Zlabinger * , Peter Steinberger*

BONE MICROSTRUCTURE IN OSTEOMYELITIS Christine Lamm1, Ursula Föger-Samwald1, Martin Dockner2, Bettina Pospischek3, Beatrix Patzak3, Michael Pretterklieber4, Gerhard W. Weber2, Peter Pietschmann1 GENERATION OF NEW CASSETTE VECTORS FOR THE TARGETED PRESENTATION OF HUMAN-RELEVANT ALLERGENS IN HUMANIZED MOUSE MODELS Bernhard Kratzer, Alina Neunkirchner, Winfried F. Pickl CSPG4 EXPRESSED BY 518A2 MELANOMA CELLS IS SHEDDED BY MATRIX METALLOPEPTIDASES AFTER PLX4032 TREATMENT UNDER NORMOXIC AND HYPOXIC CONDITIONS Sona Kontsekova1, Daniela Pucciarelli1, Nina Lengger1, Heimo Breiteneder1, Silvia Pastorekova2, Christine Hafner1 EFFECTS OF CHEMOTHERAPY OF SMALL CELL LUNG CANCER ON PH REGULATING PROTEINS Klameth L1,2, Redl 1,2, Thalhammer T1, Ellinger I1, Hamilton G2

MECHANICAL FORCES IN T-CELL ANTIGEN RECOGNITION Florian Kellner 1, Janett Göhring 1,2, Lukas Schrangl 2, Gerhard Schütz, Johannes Huppa SCHLAFEN GENE FAMILY MEMBER 12 (SLFN12) IS REQUIRED FOR HUMAN RHINOVIRUS (HRV) REPLICATION IN HELA-OHIO Anna-Maria Kapsch1, Alexander Puck1, Otto Majdic1, Petra Cejka1, Gerhard Zlabinger1, Dieter Blaas2 and Johannes Stöckl1

GENERATION OF A MULTI-PARAMETER REPORTER T CELL LINE Sabrina Jutz, Judith Leitner, Klaus Schmetterer, Katharina Grabmeier-Pfisterhammer, Peter Steinberger COMPARISON OF THE IMMUNOGENICITY AND REACTOGENICITY AFTER SUBCUTANEOUS OR INTRA MUSCULAR VACCINATION WITH A TICK-BORNE ENCEPHALITIS VACCINE Stefan Hopf1, Erika Garner-Spitzer1, Michael Hofer1, Ingrid Demel1, Michael Kundi2, Otfried Kistner3 and Ursula Wiedermann1

THE ABILITY OF THE MAJOR COW MILK ALLERGEN, BOS D 5, TO MANIPULATE T-HELPER CELLS DEPENDS ON ITS LOAD WITH SIDEROPHORE-BOUND IRON. F. Roth-Walter 1, L. F. Pacios2, C. Gomez-Casado2, G. Hofstetter 1, G. A. Roth4, J. Singer5, A.Diaz-Perales2, E.Jensen-Jarolim1,5



WORKSHOP 6 (SP51 – SP60) Chairpersons: Regina Sommer, Peter Steinberger AZITHROMYCIN INHIBITS IL-1β SECRETION OF INNATE IMMUNE CELLS BY SPECIFICLY INHIBITING THE NLRP3 INFLAMMASOME Guido A. Gualdoni1, Tilman R. Lingscheid2, Peter Steinbeger1, Gerhard J. Zlabinger1

1,25-DIHYDROXYVITAMIN D3 MODULATES THE WNT-PATHWAY IN COLORECTAL ADENOMA CELLS Charlotte Gröschel (1), Abhishek Aggarwal (1), Samawansha Tennakoon (1), Julia Höbaus (1), Maximilian Wohlgenannt (1), Teresa Manhardt (1), Brigitte Marian (2), Enikö Kállay (1)

BET V 1, A LIPOCALIN-LIKE ALLERGEN, MANIPULATES T-HELPER CELLS DEPENDING ON ITS LOAD WITH SIDEROPHORE-BOUND IRON F. Roth-Walter F1, C. Gomez-Casado2, L. F. Pacios2, N. Mothes –Luksch3, G. Hofstetter1, J. Gotovina1, G. A. Roth4, J. Singer5, A. Diaz-Perales2, E. Jensen-Jarolim1,5

THE ROLE OF HISTONE DEACETYLASE 1 (HDAC1) IN T HELPER 17 CELLS AND AUTOIMMUNITY Lisa Göschl1,2, Teresa Preglej2 Liisa Andersen2, Ari Waisman3, Patrick Mathias4, Christian Seiser5, Günter Steiner1, Wilfried Ellmeier2

THE SENSITIZATION POTENTIAL OF THE MAJOR BIRCH POLLEN ALLERGEN BET V 1 MAY ARISE FROM ITS ABILITY TO TRANSPORT LIPIDS Barbara Gepp1, Nina Lengger1, Florian Gruber2, Michael Mildner2, Heimo Breiteneder1

LOCALIZATION OF RHINOVIRUS AND NUTRIENT RECEPTORS IN THE NASAL EPITHELIUM Katharina Gelles, Hana Uher1, Verena Niederberger-Leppin2, Eva Waltl2, 1Isabella Ellinger1 and Renate Fuchs1

INVESTIGATION OF VACCINE RESPONSIVENESS IN ALLERGIC PATIENTS Erika Garner-Spitzer1, Michael Hofer1, Reinhard Jarisch2, Tamar Kinaciyan3, Michael Kundi4, Ursula Wiedermann U1.

MAPPING IgG, IgG-SUBCLASS, IgA AND IgM REACTIVITY PROFILES IN AFRICAN AND EUROPEAN HIV-INFECTED INDIVIDUALS WITH AN HIV-1 CLADE C PROTEOME-BASED ARRAY Daniela Gallerano, Portia Ndlovu, Ian Makupe, Margarete Focke-Tejkl, Kerstin Fauland, Eva Wollmann, Elisabeth Puchhammer-Stöckl, Walter Keller, Elopy N. Sibanda and Rudolf Valenta

A PHL P 7-SPECIFIC IGG4 ANTIBODY INHIBITS ALLERGIC PATIENTS’ IGE CROSS-REACTIVITY TO ALLERGENS FROM THE EF-HAND FAMILY: IMPORTANCE OF AFFINITY AND DEGREE OF CROSS-REACTIVITY Elisabeth Gadermaier1, Louisa K. James2, Mohamed H. Shamji3, Katharina Blatt4, Kerstin Fauland5, Petra Zieglmayer6, Tetiana Garmatiuk1, Margarete Focke-Tejkl1, Rebecca Beavil2, Walter Keller5, Peter Valent4, Stephen R. Durham3, Hannah J. Gould2, Sabine Flicker1, Rudolf Valenta1,7

STABLE CO-CULTIVATION OF MYCOPLASMA HOMINIS AND TRICHOMONAS VAGINALIS DOES NOT DEPEND ON THE P50/VAA ARCHITECTURE Ursula Fürnkranz1, Birgit Henrich2, Julia Walochnik1



WORKSHOP 7 (SP61 – SP69) Chairpersons: Erika Garner-Spitzer, Johannes Stöckl MUSCULOSKELETAL EFFECTS OF A 246-KM ULTRAMARATHON Ursula Föger-Samwald1

, Peter Pietschmann1, Elisabeth Weiss1, Markus Thalmann2, Maria Tsironi3,

Katerina Skenderi4, Katharina Kerschan-Schindl5 A PHASE I/II XENOGENEIC CEA VACCINATION STUDY IN CANINE MAMMARY CARCINOMA PATIENTS Judit Fazekas1,2, Michael Willmann3, Marlene Weichselbaumer1,2, Josef Singer1,2, Maximilian Pagitz3, Philipp Starkl2, Regina Knittelfelder2, Kathrin Thell2, Anna Willensdorfer1,2, Johann G. Thalhammer3, Erika Jensen-Jarolim1,2 GSH SYSTEM RELATED ENZYMES ARE INVOLVED IN METHYLMERCURY (MeHg) TOXICOKINETICS AT THE HUMAN MATERNOFETAL BARRIER Isabella Ellinger1, Elisabeth Straka2, Matthias Scheinast2, Judith Pickem2, Martin Reiter1, 2, Hana Uher1,2, Harald Zeisler3, Martin Knöfler3, Hans Salzer4, Claudia Gundacker2

SYSTEM L CARRIER IS INVOLVED IN METHYLMERCURY (MeHg) TOXICOKINETICS AT THE HUMAN MATERNOFETAL BARRIER Isabella Ellinger1, Elisabeth Straka2, Matthias Scheinast2, Judith Pickem2, Jasmin Schatz 2, Hana Uher1,2, Stefan Grbic1,2, Renate Hofer1,2, Harald Zeisler3, Martin Knöfler3, Hans Salzer4, Claudia Gundacker2 RECOMBINANT FCEPSILONRI-ALPHA AS DIAGNOSTIC TOOL FOR EVALUATING ALLERGIC SENSITIZATION IN DOGS, CATS AND HORSES Lukas Einhorn*,†, Judit Fazekas*,†, Martina Muhr*,†, Alexandra Schoos*,†, Lucia Panakova‡, Krisztina Manzano-Szalai*, Kumiko Oida*,#, Josef Singer†, Erika Jensen-Jarolim*,† TOXOPLASMA GONDII-DERIVED IMMUNOMODULATORS FOR PREVENTION AND THERAPY OF ALLERGY Mirjana Drinić¹, Irma Schabussova¹, Angelika Wagner¹, Bärbel Ruttkowski², Anja Joachim², Ursula Wiedermann¹ DETERMINING THE INFLUENCE OF CELL ADHESION AND COSTIMULATION ON T-CELL ANTIGEN RECOGNITION Iago Doel-Pérez1, Mario Brameshuber2, Florian Kellner1, René Platzer1, Sebastian Königsberger1, Tamara Stary1, Johannes B. Huppa1 ESTABLISHMENT OF HOST MODEL SYSTEMS FOR TESTING THE INFECTIVITY OF VIABLE BUT NON-CULTURABLE LEGIONELLAE Elisabeth Dietersdorfer1, Barbara Schrammel2, Alexander Kirschner2, Julia Walochnik1

EFFECT OF UV IRRADIATION (253.7 NM) ON FREE LEGIONELLA AND LEGIONELLA ASSOCIATED WITH ITS AMOEBAE HOSTS Sílvia Cervero-Aragóab, Regina Sommerb, Rosa M Araujoa



WORKSHOP 8 (SP70 – SP78) Chairpersons: Michael Duchene, Anna Repic

GAUGING SIGNAL-1 STRENGTH: DOES SIGNAL ONE STRENGTH INFLUENCE THE PHENOTYPE OF HUMAN ALLERGEN-SPECIFIC T LYMPHOCYTES? Martin R. Candia, Peter Tauber, Alina Neunkirchner, Doris Trapin, Peter Steinberger, Sandra Rosskopf, Winfried F. Pickl HYPOALLERGENIC DER P 1/DER P 2 COMBINATION VACCINES FOR IMMUNOTHERAPY OF HOUSE DUST MITE ALLERGY!Kuan-Wei Chen1, Katharina Blatt2, Wayne R. Thomas3, Ines Swoboda4, Peter Valent2, Rudolf Valenta1,4, Susanne Vrtala1

CD4(+) T CELL LINEAGE INTEGRITY IS CONTROLLED BY THE HISTONE DEACETYLASES HDAC1 AND HDAC2 Nicole Boucheron1,11, Roland Tschismarov1,11, Lisa Göschl1,2, Mirjam Moser3, Sabine Lagger3,10, Shinya Sakaguchi1, Mircea Winter3, Florian Lenz4, Dijana Vitko5, Florian P Breitwieser5, Lena Müller1, Hammad Hassan1, Keiryn L Bennett5, Jacques Colinge5, Wolfgang Schreiner4, Takeshi Egawa6, Ichiro Taniuchi7, Patrick Matthias8,9, Christian Seiser3,12 & Wilfried Ellmeier1,12

THE INFLUENCE OF ENDOTHELIAL-DERIVED MICROPARTICLES ON CLOTTING TIME IN THROMBOELASTOMETRY Bonstingl C. 1, Riedl S. 1, Hofbauer P. 1, Mühleder S. 1, Weilner S. 2, Grillari J. 2, Zipperle J. 1, Redl H. 1, Schöchl H. 1, Schlimp C.J. 1, Holnthoner W. 1

BACTERIAL GHOSTS ENHANCE THE EXPRESSION OF TOLL-LIKE RECEPTOR 2 AND PRODUCTION OF IL-6 AND IL-8 IN HUMAN CONJUNCTIVAL CELLS Nora Bintner, Sandra Belij, Elisabeth Stein, Aleksandra Inic-Kanada, Jacqueline Montanaro, Nadine Schürer, Talin Barisani-Asenbauer

INDUCTION OF ANERGY IN HUMAN T CELLS VIA TRANSFERRIN RECEPTOR (CD71) Verena Berg, Madhura Modak, Petra Cejka, Otto Majdic, Johannes Stöckl

CHLAMYDIA CAVIAE-SPECIFIC SERA ANTIBODIES NEUTRALIZE INFECTION OF CONJUNCTIVAL EPITHELIAL CELLS IN VITRO Sandra Belij-Rammerstorfer1, Aleksandra Inic-Kanada1, Marijana Stojanovic2, Elisabeth Stein1, Nora Bintner1, Jacqueline Montanaro1, Nadine Schürer1, Talin Barisani-Asenbauer1

MOLECULAR ANALYSIS OF MAZR FUNCTION IN CD4+ T CELLS Liisa Andersen, Alexandra Schebesta, Alexandra Gülich, Shinya Sakaguchi and Wilfried Ellmeier

THE ROLE OF ALVEOLAR EPITHELIAL TYPE 2 CELLS IN UPTAKE OF STRUCTURALLY DIFFERENT ALLERGENS AND THEIR CONTRIBUTION IN POLARISATION OF LOCAL IMMUNE RESPONSES Johnnie Akgün1, Irma Schabussova1, Martin Schwarzer2, Hana Kozkova2, Ursula Wiedermann1

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