Principal Investigator Istituzione Codice AIFA Area ... Siciliano Gabriele; Department of Clinical and Experimental Medicine, Neurological Clinics, University of Pisa TRS-2018-00001625

Principal Investigator Istituzione Codice AIFA Area tematica Titolo Punteggio

Siciliano Gabriele

Department of Clinical and Experimental Medicine, Neurological Clinics, University of Pisa

TRS-2018-00001625 1 - Rare DiseasesDeflazacort TREATment in LMNA-related congenital muscular dystrophy: study of clinical effectiveness and search for reliable biomarkers.

5,00

Cannavò Salvatore University of Messina TRS-2018-00001591 1 - Rare DiseasesIDENTIFICATION AND VALIDATION OF NEW CIRCULATING BIOMARKERS FOR PREDICTION OF GH-SECRETING PITUITARY TUMORS SENSITIVITY TO FIRST GENERATION SOMATOSTATIN ANALOGS TREATMENT AND IMPROVEMENT OF ACROMEGALY MANAGEMENT

6,50

Scaroni CarlaEndocrine Unit, Department of Medicine DIMED, University-Hospital of Padova

TRS-2018-00001632 1 - Rare DiseasesMedical combination therapy with retinoic acid and cabergoline in ACTH-secreting pituitary adenoma: a prospective and randomized study

7,50

Crotti Lia IRCCS Istituto Auxologico Italiano TRS-2018-00001470 1 - Rare DiseasesNovel therapy for the Long QT Syndrome type 2 based on the mechanism of action of the disease-causing mutations

7,50

Chiarion Sileni Vanna Istituto Oncologico Veneto TRS-2018-00001567 3 - Gender MedicineCirculating markers as gender-specific predictors of response to Immune Checkpoint Inhibitors in melanoma and non-small-cell lung cancer patients

7,50

Perno Carlo Federico Università degli studi di Milano TRS-2018-00001336 5 - AMRStrategies to Contain HIV Drug-Resistance Emergence in Virologically Suppressed Patients Requiring Antiretroviral Therapy Optimization: Unraveling the Role of Mutational Burden in PBMCs

7,50

Saccà Francesco University Federico II TRS-2018-00001358 1 - Rare DiseasesA double-blind, randomized, placebo-controlled trial to test the efficacy, safety and tolerability of Dimethylfumarate in Friedreich Ataxia (DMF-FA-201).

7,50

Villa EricaUniversity of Modena and Reggio Emilia

TRS-2018-00001238 3 - Gender Medicine Gender-related response to Tyrosine Kinase-Inhibitor drugs in hepatocellular carcinoma 7,50

Voso Maria Teresa Universita' di Roma Tor Vergata TRS-2018-00001687 1 - Rare DiseasesProspective randomized study on the feasibility of allogeneic stem cell transplantation in higher-risk-myelodysplastic syndromes, performed upfront or preceded by azacitidine or conventional chemotherapy, according to the BM-blast proportion (ACROBAT trial)

9,00

Bassi Claudio AOUI Verona TRS-2018-00001695 5 - AMRAntibiotic stewardship program in pancreatic surgery: a multicenter time series analysis.

9,00

Milani PaoloFoundation IRCCS Policlinico San Matteo

TRS-2018-00001624 1 - Rare DiseasesA multi-center open label phase II study of daratumumab and pomalidomide in previously treated patients with AL amyloidosis.

9,00

Disma Nicola Massimo Istituto Giannina Gaslini TRS-2018-00001250 2 - Pediatric DiseasesNeurodevelopmental outcome after standard dose sevoflurane versus low-dose sevoflurane/dexmedetomidine/remifentanil anaesthesia in young children. The TREX Study.

9,00

Piperno AlbertoASST- Monza Ospedale San Gerardo

TRS-2018-00001468 1 - Rare DiseasesReplacement of ceruloplasmin through transfusion of plasma from selected high ceruloplasmin expressing donors as a novel therapeutic approach to revert systemic and neurological derangements in aceruloplasminemia

9,25


Finocchiaro GaetanoFondazione IRCCS Istituto Neurologico Besta

TRS-2018-00001312 1 - Rare DiseasesDendritic cell IMmunotherapy with or without concomitant local chemotherapy in patients with PROgressiVE glioblastomas.

9,50

Bonovas Stefanos IRCCS Istituto Clinico Humanitas TRS-2018-00001654 4- Safety ElderlyBiologic therapies in inflammatory bowel disease: systematic review and meta-analysis of harmful effects in elderly patients

9,50

Garufi CarloOspedale Spirito Santo, ASL Pescara

TRS-2018-00001568 3 - Gender MedicineA prospective multicentric trial investigating clock-gene signature and sex-effect in Italian advanced colorectal cancer patients treated according to RAS/BRAF status

9,50

Marchetti PaoloSapienza Università di Roma- Azienda Ospedaliero-universitaria Sant'Andrea

TRS-2018-00001524 4- Safety ElderlyClinical Management of Polypharmacy in Elderly: Personalized medical approach in geriatric poly-treated Patients to increase drugs safety, drug efficacy and adherence to treatments

9,50

Buonocore Giuseppe Università degli studi di Siena TRS-2018-00001534 2 - Pediatric Diseases PREterm infants treated with MELatonin: an innovative medical CARE 9,50

Lemoli Roberto M.Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa

TRS-2018-00001792 1 - Rare DiseasesA reduced intensity induction chemotherapy with increased anti-metabolic activity for elderly Philadelphia-negative acute lymphoblastic leukemia patients

10,00

Corsini AlbertoDep. Pharmacological and Biomolecular Sciences, University of Milan

TRS-2018-00001561 4- Safety ElderlyManage polypharmacy in elderly: development of tools for medication review and deprescribing built on real-world data and intervention study on general practitioners

10,00

Bossi PaoloFondazione IRCCS Istituto Nazionale dei Tumori

TRS-2018-00001248 1 - Rare DiseasesTO PROVE THE CONCEPT OF AN IMMUNOMEDIATED EFFECT OF DENOSUMAB BY REPURPOSING IT IN NON-ENDEMIC, EBV-RELATED NASOPHARYNGEAL CANCER AND BIOMARKER VALIDATION.

10,00

Di Cosimo SerenaFondazione IRCCS Istituto Nazionale dei Tumori

TRS-2018-00001592 1 - Rare DiseasesA tRanslational research prOject to amenD clinIcal practice for metapLastic carcInoma of the breAst (MPBC): the RODILIA Study

10,00

Maghnie Mohamad Istituto Giannina Gaslini TRS-2018-00001422 1 - Rare DiseasesEfficacy of FSH+testosterone and FSH+hCG after pre-treatment with FSH compared to standard testosterone therapy on testicular volume and quality of life during pubertal induction: a randomized trial in hypogonadotropic hypogonadism patients (FaTHEr study)

10,00

Aguglia UmbertoMagna Graecia University of Catanzaro

TRS-2018-00001576 3 - Gender MedicineInfluence of hormonal contraceptives on seizure frequency and depression in women with epilepsy: multicentre, longitudinal, prospective, cohort study.

10,00

Sansone Valeria ANeurorehab Unit, University of Milan, The NEMO Clinical Center

TRS-2018-00001732 1 - Rare DiseasesRILUZOLE FOR SYMPTOMS AND SIGNS OF MYOTONIA AND PAIN IN MYOTONIC DYSTROPHIES: A CROSS-OVER RANDOMIZED CONTROLLED TRIAL

10,00

Auriti CinziaOspedale Pediatrico Bambino Gesù

TRS-2018-00001360 5 - AMRFluconazole prophylaxis against fungal colonization and invasive infections in newborns and infants with majorsurgical pathologies: a multicenter prospective double blind randomized clinical trial.

10,00

Cappuzzo Federico Ospedale S. Maria delle Croci TRS-2018-00001787 4- Safety ElderlyAn open-label, randomized phase III study of immunotherapy versus chemotherapy or best supportive care as second-line treatment of elderly patients with advanced non-small cell lung cancer

10,00


Pozzilli Carlo Sapienza University of Rome TRS-2018-00001615 3 - Gender MedicineGender differences in the effectiveness and safety of preventive treatment of Relapsing-Remitting Multiple Sclerosis: a multicenter, longitudinal real-world cohort study

10,00

Onder GrazianoUniversitá Cattolica del Sacro Cuore

TRS-2018-00001476 4- Safety ElderlyFrailty, drug use and health-related outcomes in three clinical settings: generating evidence to guide drug prescription in frail older adults

10,00

Cattoretti GiorgioUniversita degli Studi Milano-Bicocca

TRS-2018-00001486 1 - Rare DiseasesBiomarker-driven single-cell lung pathology prediction of disease progression and therapeutic response in idiopathic pulmonary fibrosis.

10,00

Iorio Raffaele University Federico II Naples TRS-2018-00001478 1 - Rare DiseasesA multicenter, randomized, cross-over trial to assess the benefits of domperidone in Wilson Disease

10,00

Ruscitti Piero University of L'Aquila TRS-2018-00001458 1 - Rare DiseasesSearching for the best therapeutic strategy in rare paediatric monogenic autoinflammatory diseases: the effectiveness of anti-interleukin 1 biologic drugs. A systematic review and meta-analysis

10,00

Ceccherini Silberstein Franc University of Rome Tor Vergata TRS-2018-00001311 5 - AMRHCV resistance surveillance in HCV mono and HIV/HCV co-infected patients failing a DAA containing IFN-free regimen across all genotypes circulating in Italy

10,00

Di Raimondo FrancescoAOU Policlinico Universitario di Catania

TRS-2018-00001636 1 - Rare DiseasesDevelopment of a Myeloma Immune Dysregulation Score to personalize treatment in elderly patients: the MIDS observational study

10,50

Invernizzi Pietro ASST Monza TRS-2018-00001259 1 - Rare DiseasesPhase II one-arm, open-label, multicenter clinical trial to assess the efficacy and safety of oral NOX1/NOX4 inhibitor (GKT137831) in patients with primary sclerosing cholangitis. The NOX-PSC study

10,50

Renieri AlessadraAzienda Ospedaliera Universitaria Senese

TRS-2018-00001557 1 - Rare DiseasesAmiloride repurposing and CRISPR/Cas9 Gene Therapy for a Combined Personalized Therapeutic Strategy in Alport Syndrome.

10,50

Vignoli AglaiaChildhood and Adolescence Neurology and Psychiatry - Department of Health Sciences

TRS-2018-00001392 1 - Rare DiseasesRepurposing Mirtazapine to target the Rett syndrome: a randomized placebo-controlled Phase II multicenter study to evaluate safety and efficacy.

10,50

Scarpa MaurizioDepartment For the Woman and Child Health University of Padova, Padova, Italy

TRS-2018-00001637 1 - Rare DiseasesInformation Technology approach to explore the impact of therapies and the cost of rare inherited metabolic disorders.

10,50

Prodam FlaviaDepartment of Health Sciences, University of Piemonte Orientale

TRS-2018-00001460 3 - Gender MedicineGender and age-related responses to the treatment with long-acting GLP-1 receptor agonists in type 2 diabetes and obesity: a systematic review and meta-analysis

10,50

Landoni Giovanni Fondazione Centro San Raffaele TRS-2018-00001438 4- Safety ElderlyManagement of Angiotensin-conveRting enzyme inhibitoGs/angiotensin Receptor blockers and statIns before cArdiac and non-cardiac surGery in the Elderly. A multicenter, randomized trial.

10,50

Silani Vincenzo IRCCS Istituto Auxologico Italiano TRS-2018-00001613 1 - Rare DiseasesActivity and lomg term safety of Fingolimod in Amyotrophic Lateral Sclerosis (ALS): a Phase IIb study

10,50

Dionisi Vici CarloOspedale Pediatrico Bambino Gesù

TRS-2018-00001743 1 - Rare DiseasesAn observational multicenter longitudinal study to evaluate the impact on developmental aspects and cost-effectiveness of Liver Transplantation in Intoxication type Metabolic Diseases in a rapidly evolving therapeutic era.

10,50

Tartaglia MarcoOspedale Pediatrico Bambino Gesù

TRS-2018-00001752 1 - Rare DiseasesNatural history, patient stratification and personalized medicine in RASopathies: from registry to care

10,50


Simoni Manuela

Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia

TRS-2018-00001386 3 - Gender MedicineToward reduction of the burden of assisted reproduction technologies in women suffering from couple infertility due to male factor: assessing the pharmacodynamics of human recombinant luteinising hormone in hypogonadal men

10,50

Clementi Emilio Giuseppe Università di Milano TRS-2018-00001477 2 - Pediatric DiseasesCardiometabolic risk in children naïve to second generation antipsychotics treatment, an observational Italian cohort study with genetic biomarkers.

10,50

Marengoni Alessandra University of Brescia TRS-2018-00001507 4- Safety ElderlySARCopenia and Adverse Drug Reactions in older persons prescribed with polypharmacy: gender differences- SARC-ADR

10,50

Cox Maria Christinaazienda ospedaliera universitaria sant'andrea

TRS-2018-00001508 1 - Rare DiseasesPhase II study of Immunotherapy based on intra-nodal IFN-DC and/or Rituximab in Follicular Lymphoma

11,00

Cingolani AntonellaUniversità Cattolica del Sacro Cuore

TRS-2018-00001376 3 - Gender Medicine

Role of menopausal status on hepatic and extra hepatic events in HIV-HCV co-infected women: interplay with anti HCV Direct Antiviral Agents (DAA) and with Hormone Replacement Therapy (HRT) 11,00

Lunetta ChristianCentro Clinico NEMO - Fondazione Serena Onlus

TRS-2018-00001780 1 - Rare Diseases Edaravone for Amyotrophic Lateral Sclerosis: an open label multicenter clinical trial 11,00

Lauro DavideDepartment of Systems Medicine, University of Rome Tor Vergata, Italy

TRS-2018-00001667 4- Safety ElderlyNew Therapeutic Strategies for Type 2 Diabetes Mellitus in Elderly: Prevention of Cognitive Decline and Frailty

11,00

Selmi Carlo Humanitas Research Hospital TRS-2018-00001702 3 - Gender MedicineSAFETY AND EFFICACY OF BIOLOGIC AGENTS AND TARGETED SYNTHETIC DMARDS IN WOMEN AND ELDERLY PATIENTS WITH INFLAMMATORY ARTHRITIS: A STUDY PROTOCOL FOR A SYSTEMATIC LITERATURE REVIEW AND META-ANALYSIS

11,00

Zecca MarcoOncoematologia pediatrica, Fondazione IRCCS Policlinico San Matteo

TRS-2018-00001503 1 - Rare DiseasesPhase I/II clinical trial of somatic cell therapy with donor-derived anti-leukemia cytotoxic T lymphocytes for prevention of relapse in children given haploidentical hematopoietic stem cell transplantation.

11,00

Savonitto Stefano Ospedale Alessandro Manzoni TRS-2018-00001488 4- Safety ElderlyTwo-month dual antiplatelet treatment in elderly patients with Acute Coronary Syndromes. A randomised comparison with standard 12-month treatment.

11,00

Camerota Filippo Policlinico Universitario Umberto I TRS-2018-00001552 1 - Rare DiseasesAssessing and predicting duloxetine efficacy and safety for treating pain in patients with joint hypermobility syndrome/Ehlers-Danlos syndrome

11,00

Manunta Paolo San Raffaele Scientific Institute TRS-2018-00001720 4- Safety ElderlyCOST-EFFECTIVENESS OF PERSONALIZED DIURETIC THERAPY IN AN ELDERLY POPULATION: BODY SODIUM HOMEOSTASIS AND INFLAMMATION

11,00

Falsini Benedetto Universita Cattolica del S. Cuore TRS-2018-00001314 1 - Rare DiseasesTreatment of Non-cell Autonomous Cone Photoreceptor Degeneration in Retinitis Pigmentosa. A ¿Rescue and Restore¿ Strategy Targeting Oxidative Defense and Energy Metabolism

11,00

Di Leo Alfredo Università degli Studi di Bari TRS-2018-00001582 5 - AMRComparison of antibiotic susceptibility-guided therapy versus empiric concomitant non-bismuth quadruple regimen as first-line treatment for Helicobater pylori infection in people receiving hemodialysis: a randomized controlled trial.

11,00


Padovani Alessandro University of Brescia TRS-2018-00001699 1 - Rare DiseasesSafety and biological effect of trazodone in Progressive Supranuclear Palsy: a 24-weeks placebo-controlled double blind pilot trial

11,00

Parazzini Fabio University of Milan TRS-2018-00001502 3 - Gender MedicineEffect of supplmentation with Vitamin D and high doses of folic acid in improving in vitro fertilization outcome: a factorial double blind randomized clinical trial.

11,00

Benemei SilviaCareggi Hospital -University of Florence

TRS-2018-00001481 1 - Rare DiseasesThe RegistRare Network Prospective Initiative: a cohort prospective study and a registry to collect gender-based data on drug utilization and burden of rare primary headaches in patients referring to Italian tertiary Headache Centres.

11,50

Tedeschi Gioacchino

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli"

TRS-2018-00001516 1 - Rare DiseasesDetection of Plasma and neuroimaging biomarkers of oxidative stress for monitoring the antioxidant effect of Edaravone in Amyotrophic Lateral Sclerosis (ALS)

11,50

Cittadini Antonio Federico II University of Naples TRS-2018-00001635 4- Safety ElderlyMETformin in Old fragile patients affected by Heart Failure with Preserved Ejection fraction with insulin-resistance.

11,50

Palla Roberta Fondazione Luigi Villa TRS-2018-00001298 1 - Rare DiseasesmAPP the drug: a pharmacovigilance system of extended half-life treatment products for hemophilia

11,50

Chimenti Cristina La Sapienza University TRS-2018-00001406 1 - Rare DiseasesImmune-Mediated Myocarditis in Fabry Disease Cardiomyopathy. Immunosuppression May Contrast DiseaseProgression and Resistance To Enzyme Replacement Therapy: Proof of Concept.

11,50

Pinnetti CarmelaNational Institute for Infectious Disease "L. Spallanzani"

TRS-2018-00001485 4- Safety ElderlyA randomized controlled trial to assess the protective effect of atorvastatin on the HIV-associated neurocognitive disorders (HAND) in older HIV-infected individuals

11,50

Ferrari Giulio Ospedale San Raffaele TRS-2018-00001678 1 - Rare DiseasesSafety and efficacy of topical Fosaprepitant in the treatment of ocular cicatritial pemphigoid: monocentric, randomized, double blind cross-over clinical trial

11,50

Fantini Maria Pia University of Bologna TRS-2018-00001464 5 - AMRImprovement of antibiotic use in hospitals through pragmatic, multifaceted, computerized interventions: two sequential randomised controlled trials

11,50

Staszewsky LidiaIRCCS-Istituto di Ricerche Farmacologiche Mario Negri

TRS-2018-00001383 4- Safety ElderlyInsulin treatment in Older people with Heart Failure and Diabetes, INSIDE-HF: a prospective randomized trial.

11,75

Ungar Andrea AOU Careggi TRS-2018-00001292 4- Safety ElderlyMonitoring Older subjects with DEmentia to Reduce Antihypertensive ThErapy (MODERATE). A randomizedcontrolled trial of treatment de-intensification

12,00

Bellelli Giuseppe ASST San Gerardo Monza TRS-2018-00001414 4- Safety ElderlyMELATONIN FOR THE PREVENTION OF INCIDENT DELIRIUM IN HOSPITALIZED OLDER PATIENTS: A RANDOMIZED CONTROLLED TRIAL

12,00

Olivotto IacopoCareggi University Hospital -Cardiomyopathy Unit_

TRS-2018-00001726 1 - Rare DiseasesA pilot study to assess the effects of ranolazine on LVOT gradients and exertional symptoms during exercise in HCM patients with dynamic obstruction.

12,00


Cirillo MassimoDept. "Scuola Medica Salernitana", University of Salerno

TRS-2018-00001558 3 - Gender MedicinePopulation-based study about sex-associated differences in 1,25(OH)2-vitamin D and objective indices of vitamin D deficiency.

12,00

Pallini RobertoFondazione Policlinico Gemelli - Università Cattolica del Sacro Cuore

TRS-2018-00001511 1 - Rare Diseases mesenchymal STem cells for Advanced Therapy Of Glioblastoma (STATOG) 12,00

Pupillo Elisabetta IRCCS Istituto Mario Negri TRS-2018-00001777 1 - Rare DiseasesThe outcome of amyotrophic lateral sclerosis and the treatment of the disease and its comorbidities

12,00

Simonini GabrieleNEUROFARBA Dpt University of Florence AOU A Meyer

TRS-2018-00001560 2 - Pediatric DiseasesRandomized controlled trial to evaluate the eFficacy and safety of Adalimumab in combination with methotrexate as firST line therapy in children with Juvenile Idiopathic Arthritis associated uveitis

12,00

Cancrini CaterinaOspedale Pediatrico Bambino Gesù

TRS-2018-00001538 1 - Rare DiseasesAn open-label exploratory study of theophylline in subjects with activated phosphoinositide 3 kinase (PI3K) delta syndrome (APDS) and autoimmune lymphoproliferative syndrome (ALPS).

12,00

Cianfarani StefanoOspedale Pediatrico 'Bambino Gesù'

TRS-2018-00001626 2 - Pediatric DiseasesImpact of continuous glucose monitoring technology and different basal insulin regimens on cognitive function and glycemic control in children with Type 1 Diabetes.

12,00

Specchio NicolaOspedale Pediatrico Bambino Gesù, IRCCS

TRS-2018-00001510 2 - Pediatric DiseasesAssessment of value, safety and efficacy of personalized therapy in undiagnosed non-syndromic epilepsy (E) and intellectual disabilities (ID).

12,00

Martelli Maria PaolaUniversità degli studi di Perugia, Dipartimento di Medicina

TRS-2018-00001234 1 - Rare Diseases

A novel chemo-free approach by drug repurposing in acute myeloid leukemia: "A Phase IIa Study of The Clinical Activity and Safety of Combined Omacetaxine Mepesuccinate (Synribo) and Venetoclax (Venclyxto) in Patients with Relapsed/Refractory Acute Myeloid Leukemia with Nucleophosmin (NPM1) Gene Mutation"

12,00

Strippoli GiovanniUniversity of Bari - Department of Emergency and Organ Transplant

TRS-2018-00001540 4- Safety ElderlyValue-based versus intensified pharmaceutical care for hemodialysis patients: A pragmatic, open-label, blinded endpoint, non-inferiority, randomized controlled trial (VALUE-HD)

12,00

Ferlini Alessandra University of Ferrara TRS-2018-00001417 1 - Rare DiseasesIDENTIFICATION OF NOVEL DISEASE GENES IN RARE NEUROMUSCULAR DISORDERS BY NEW INTEGRATED GENOME AND TRANSCRIPTOME DATA ANALYSIS AND GENE EDITING

12,00

Brandi Maria Luisa University of Florence TRS-2018-00001519 1 - Rare Diseases Italian network and registry for chronic hypoparathyroidism. 12,00Corrao Giovanni University of Milano-Bicocca TRS-2018-00001387 4- Safety Elderly Risks and benefits of reducing polypharmacy in elderly outpatients 12,00

Gemmati DonatoAzienda Ospedaliera - Universitaria di Ferrara

TRS-2018-00001290 3 - Gender MedicineGender-specific prognostic biomarker(s) to early predict Left Ventricular Remodeling after Acute Myocardial Infarction and to evaluate gender-specific different effectiveness of anti-remodeling drugs: a three years observational longitudinal study.

12,50

Clementi Maurizio Dept SDB University of Padua TRS-2018-00001735 3 - Gender MedicineMaternal and fetal risks associated with the pharmacologic treatment of rheumatic autoimmune diseases during pregnancy.

12,50

Vullo VincenzoDipartimento di Sanità Pubblica e Malattie Infettive Università Sapienza

TRS-2018-00001585 4- Safety ElderlyStudy of the effects of probiotic supplementation on neurocognitive function in elderly HIV infected subjects

12,50


Esposito SusannaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

TRS-2018-00001297 2 - Pediatric DiseasesTRYPTOphan metabolism as potential biomarker for personalized immunotherapy in autoimmune diabetes: a proof-of-concept study with tocilizumab in children and adolescents with type 1 DIAbetes

12,50

Raimondi Ferdinando Humanitas Research Hospital TRS-2018-00001730 5 - AMRREal time mass SPEctrometry analysis of volatile organic Compounds for Targeted antibiotic therapy in Ventilator Associated Pneumonia: The RESPECT-VAP study

12,50

Eleopra RobertoIRCCS Fondazione Istituto Neurologico Carlo Besta

TRS-2018-00001512 1 - Rare DiseasesBOTULINUM TOXIN A INJECTIONS IN CERVICAL AND TRUNCAL MUSCLES TO TREAT ISOLATED AXIAL DYSTONIA: A DOUBLE-BLIND RANDOMIZED PHASE-III TRIAL

12,50

Guidoboni Massimo IRCCS IRST TRS-2018-00001462 1 - Rare DiseasesPembrolizumab associated with autologous dendritic cell vaccine in patients with PD-L1 negative advanced mesothelioma who have failed prior therapies: a phase Ib study

12,50

Anghileri ElenaIRCCS Istituto Neurologico Carlo Besta

TRS-2018-00001330 1 - Rare Diseases Metformin as repurposed drug in newly diagnosed glioblastoma 12,50

Fossati Roldano IRCCS Mario Negri Institute TRS-2018-00001675 1 - Rare DiseasesPhase III, multicenter, randomized trial comparing metformin plus standard platinum-based therapy with standard platinum-based therapy alone in women with relapsed platinum sensitive epithelial ovarian cancer.

12,50

Baviera MartaIRCCS-Istituto di Ricerche Farmacologiche "Mario Negri"

TRS-2018-00001442 4- Safety ElderlyEffectiveness and safety of the new antihyperglycemic drugs (GLP-1 receptor agonists and SGLT2 inhibitors) in the real world: a large-scale evaluation in the elderly population.

12,50

Ascierto Paolo AntonioIstituto Nazionale Tumori Fondazione "G. Pascale"

TRS-2018-00001701 4- Safety ElderlyDURANIVOL study: defining treatment DURAtion of NIVOlumab in eLderly patients with unresectable or metastatic melanoma treated for two years and with a clinical benefit from treatment (complete or partial responder or stable disease)

12,50

Rosati Anna Meyer Children's Hospital TRS-2018-00001308 2 - Pediatric DiseasesPersonal and health system implications of pseudo-intractability in pediatric epilepsy: a multicentre, national, real world, retro-prospective, observational cohort study.

12,50

Pontrelli GiuseppeOspedale Pediatrico Bambino Gesù

TRS-2018-00001790 5 - AMRPROcalcitonin Guidance for antibiotic REduction in Suspected paediatric Sepsis (PROGRESS 2.0): a multicenter randomised controlled trial.

12,50

Ardizzoni Andrea Policlinico S.Orsola-Malpighi TRS-2018-00001305 4- Safety Elderly

A MULTICENTER RETROSPECTIVE-PROSPECTIVE COHORT STUDY TO INVESTIGATE OUTCOMES OF VERY ELDERLY ( >=80 YEARS-OLD) PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER TREATED WITH IMMUNE-CHECKPOINT INHIBITORS

12,50

Giannella MaddalenaSant'Orsola-Malpighi Hospital, University of Bologna

TRS-2018-00001551 5 - AMRA multi-arm multi-stage randomized clinical trial comparing three different ceftazidime-avibactam based regimens for carbapenemase producing Enterobacteriaceae bacteremia

12,50

Taliani GloriaSapienza University of Rome, Policlinico Umberto I

TRS-2018-00001622 3 - Gender MedicineCardiovascular and cerebrovascular events in HCV: gender differences and impact of clinical monitoring and treatment

12,50

Quattrocchi Carlo CosimoUniversità Campus Bio-Medico di Roma

TRS-2018-00001650 4- Safety ElderlySAfety of GAdolinium-Based Contrast agents and Efficacy toward optimizing the use of biological therapy: a focused survey on elderly and ultraelderly population

12,50


Lambiase AlessandroUniversità di Roma "Sapienza" - Dipartimento Organi di Senso

TRS-2018-00001517 1 - Rare DiseasesMulticenter, randomized, double-blind, vehicle-controlled clinical trial to evaluate safety and efficacy of Cenegermin eye drops treatment in patients with mucous membrane pemphigoid (MMP).

12,50

Pantaleo Maria AbbondanzaUniversity of Bologna Azienda Opsedaliero Universiatria Po. Sant'Orsola Malpighi

TRS-2018-00001310 1 - Rare DiseasesExploratory phase II Basket trial of precision treatments selected by NGS analysis in rare tumors or rare sub-type tumors non oncogenic-addicted or resistant to approved drugs

12,50

De Giorgio Roberto University of Ferrara TRS-2018-00001335 1 - Rare DiseasesPYridostigmine treatment for GAstrointestinal manifestations in Systemic Sclerosis (PYGASS): A randomised, double-blind, placebo-controlled study

12,50

Scichilone Nicola University of Palermo TRS-2018-00001550 4- Safety ElderlyEfficacy and safety of anti-IL5 treatment in asthma across ages: a metanalysis and systematic review.

12,50

Previtali Stefano Fondazione Centro San Raffaele TRS-2018-00001367 1 - Rare DiseasesA mini-invasive and multidisciplinary approach to monitor disease activity and response to therapy in inflammatory idiopathic myopathies (IIM)

12,75

Viale PierluigiAlma Mater Studiorum Università di Bologna

TRS-2018-00001407 5 - AMRIs it possible to improve patient outcomes and reduce the duration of antibiotic therapy for Enterobacteriaceae bacteriemia? A cluster-randomized multicenter study with application of a bundle strategy

13,00

Grandaliano GiuseppeAOU "Ospedali Riuniti", Università degli Studi di Foggia

TRS-2018-00001237 4- Safety ElderlyMulticenter, controlled, randomized clinical trial to Valuate the efficacy of Etelcalcetide therapy in LOwering the incidence of Cardiovascular Events in elderly hemodialysis subjects with secondary hyperparathyroidism

13,00

Lapolla AnnunziataDiabetology and Dietetics, ULSS 6 Euganea

TRS-2018-00001793 4- Safety ElderlyVIRGILIO(VIgilance Registry of GerIatric patients with diabetes newly treated with glucose Lowering agents: a north-east Italy Observational prospective study)

13,00

Bugianesi ElisabettaDipartimento di Scienze Mediche, Università di Torino

TRS-2018-00001401 3 - Gender MedicineGender differences in the epidemiology and the severity of Non Alcoholic Fatty Liver Disease in T2DM: the role of glucose-lowering therapy

13,00

Esposito Giovanni Federico II University TRS-2018-00001461 4- Safety ElderlyA Randomized Prospective Study to Assess the Efficacy of Tranexamic Acid on Reduction of Early Bleeding Events in Elderly Patients Undergoing Transcatheter Aortic Valve Implantation.

13,00

Pasqualetti PatrizioFondazione Fatebenefratelli per la Ricerca e la Formazione Sanitaria e Sociale

TRS-2018-00001571 3 - Gender MedicineLong-term Effects in school age children following exposure to Antidepressants During pregnancy: a case-control study

13,00

Della Porta Matteo GiovannIRCCS Humanitas Research Hospital

TRS-2018-00001446 1 - Rare DiseasesMulticenter observational study of patients with myelodysplastic syndrome (MDS) in Italy, as a basis for theimplementation of precision medicine programs in a rare disease

13,00

Iatropoulos ParaskevasIRCCS-Istituto di Ricerche Farmacologiche Mario Negri

TRS-2018-00001683 1 - Rare DiseasesIntegrating Deep Phenotyping and 'Omics' approaches to unravel pathogenetic patterns in Primary Nephrotic Syndrome and orient Therapies.

13,00

Taruscio Domenica Istituto Superiore di Sanità TRS-2018-00001436 1 - Rare Diseases Italian Network for solving undiagnosed rare diseases 13,00

Amore MarioPsychiatric Clinic, DINOGMI, University of Genoa

TRS-2018-00001545 4- Safety ElderlyDeprescribing in Elderly Depressed Improving Cardiovascular health And sTability with Exercise (DEDICATE study)

13,00

Ciccozzi Massimo università campus biomedico TRS-2018-00001527 5 - AMR A Multicentre longitudinal study on antimicrobial resistant: learn how to fight 13,00


Miraglia Del Giudice EmanuUniversità della Campania "Luigi Vanvitelli"

TRS-2018-00001403 2 - Pediatric DiseasesLiraglutide in the management of weight loss in obese adolescents: a randomized controlled trial

13,00

Durante Mangoni EmanueleUniversità della Campania 'L. Vanvitelli'

TRS-2018-00001271 5 - AMREfficacy of colistin plus minocycline compared to colistin alone for severe infections due to carbapenem-resistant Acinetobacter baumannii: an open label, randomised, multicentre clinical trial (EnCOMIA-Evaluation of COlistin plus MInocycline for Acinetobacter)

13,00

Perrotta SilverioUniversity of Campania "L. Vanvitelli"

TRS-2018-00001712 1 - Rare DiseasesA prospective clinical, genetic and metabolic evaluation of Italian Familial Erythrocytosis' patients to improve therapies' appropriateness and find new areas of clinical intervention.

13,00

Gallieni Maurizio Alberto

University of Milano - Dipartimento di Scienze Biomediche e Cliniche 'L. Sacco' - DIBIC

TRS-2018-00001359 4- Safety Elderly

IntraVenous saline solution versus ORal hydration for preventing contrast induced nephropathy (CIN) in elderly patients with chronic kidney disease (CKD) stage 3b and 4. The IVOR-CKD contrast nephropathy study. A randomized, open label, multicenter, phase III, non-inferiority trial.

13,00

Martinelli GiovanniAzienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi


Low intensity combination therapy with E. Coli asparaginase and cytarabine in relapsed/refractory acute myeloid leukemia patients carrying monosomy 7, del(7q) or focal deletion of 7q21. 13,50

Gambineri AlessandraDept. of Medical and Surgical Sciences, University of Bologna

TRS-2018-00001754 1 - Rare DiseasesComprehensive steroid profiling in serum and saliva for improving diagnosis and tailoring therapy of Non Classical Congenital Adrenal Hyperplasia due to 21-hydroxylase deficiency in children and adults

13,50

Simonetti GiorgiaFondazione IRCCS Neurologico Carlo Besta

TRS-2018-00001295 1 - Rare DiseasesThe Role of Chemotherapy in adult Recurrent Atypical and Anaplastic Meningiomas: a systematic review and a network meta-analysis.

13,50

Caltagirone Carlo Fondazione Santa Lucia IRCCS TRS-2018-00001254 1 - Rare DiseasesGenistein for treatment of motor and cognitive symptoms of the early stage of Progressive Supranuclear Palsy

13,50

De Cobelli Francesco IRCCS Ospedale San Raffaele TRS-2018-00001434 1 - Rare DiseasesIdentification of hybrid imaging (PET/MRI) and molecular biomarkers to predict vascular progression in patients with large vessel vasculitis (LVV) to improve the appropriateness of biologic treatment

13,50

Appetecchia MarialuisaIRCCS-Istituto Nazionale Tumori Regina Elena (IRE)

TRS-2018-00001608 1 - Rare DiseasesTailored versus standard doses of recombinant human TSH in patients affected by differentiated thyroid cancer: a randomized prospective clinical trial evaluating the feasibility of precision medicine.

13,50

Vinti LucianaOspedale Pediatrico Bambino Gesù

TRS-2018-00001767 2 - Pediatric DiseasesOff-label use of propranolol to reduce brown adipose tissue activation in pediatriconcological patients undergoing 18F-FDG PET/CT

13,50

Mosca MartaRheumatology Unit, University of Pisa


The role of Intravenous Immunoglobulin (IVIG) in the induction of remission in subjects with dermatomyositis (DM) and polymyositis (PM): multicenter randomized play the winner controlled single-blind parallel group trial to evaluate the 6-month effectiveness of IVIG versus standard corticosteroids (CS) therapy

13,50

Pivonello Rosario University Federico II TRS-2018-00001457 1 - Rare DiseasesInnOvative therapies in rare disease: New replacement Treatment in adrenal Insufficiency and identification of new bio-Markers of glucocorticoid Exposure.

13,50


Pedrotti EmilioFondazione Banca degli Occhi del Veneto onlus

TRS-2018-00001518 1 - Rare DiseasesPROspective evaluation of efficacy and safety of autologous human corneal epithelial cells containing stem cells for the treatment of limbal stem cell DEficiency due to etiologies different from physical or chemical ocular burns.

14,00

Pisano Tiziana AOU Meyer TRS-2018-00001739 2 - Pediatric DiseasesChildren and Adolescent off-Label psychotropic Medicines in Emergency setting: a retrospective study of efficacy and safety.

14,00

Tascini Carlo Azienda Ospedaliera dei Colli TRS-2018-00001620 5 - AMRA double-blind, randomized, placebo-controlled, multicenter study assessing the impact of oral gentamycin on gut decolonization due to Klebsiella pneumoniae KPC: GENtamycin for GUT decontamination study

14,00

Fiorica FrancescoAzienda Ospedaliero Universitaria di Ferrara

TRS-2018-00001452 1 - Rare Diseases A translational approach for glioblastoma patients using NIMODIPINE 14,00

Murri Rita Catholic University of Rome TRS-2018-00001505 5 - AMRA prospective, multicenter, train-to-trainer Antimicrobial Stewardship Intervention study for the reduction of inappropriate antimicrobial therapy in hospital and long-term Care facilities (CHAMPIONS)

14,00

Colao AnnamariaDipartimento Medicina Clinica e Chirurgia, University Federico II

TRS-2018-00001530 1 - Rare DiseasesA multicenter, observational study on epidemiology, genetic and molecular diagnosis, and available treatments for patients with rare endocrine diseases from across reference centers in Southern Italy.

14,00

Dilena RobertinoFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

TRS-2017-00001208 2 - Pediatric DiseasesRANDOMIZED CONTROLLED TRIAL OF LEVETIRACETAM VERSUS PHENOBARBITAL AS FIRST-LINE ANTIEPILEPTIC TREATMENT OF NEONATAL SEIZURES IN ITALY

14,00

Canafoglia LauraFondazione IRCCS Istituto Neurologico Carlo Besta

TRS-2018-00001697 1 - Rare DiseasesCREATION OF AN ITALIAN DATABASE FOR PROGRESSIVE MYOCLONUS EPILEPSIES AND NOVEL TREATMENT OF THE MOST COMMON FORM, UNVERRICHT-LUNDBORG DISEASE, BASED ON THE HYPOTHESIS OF NEUROINFLAMMATION

14,00

Barbi EgidioIstituto per L'Infanzia Burlo Garofolo

TRS-2018-00001529 2 - Pediatric DiseasesPharmacogenetics and pharmacokinetics of ketamine in children presenting adverse events during procedural analgesia and sedation outside of the operating room in children

14,00

Alunno AlessiaRheumatology Unit, Department of Medicine, University of Perugia

TRS-2018-00001769 4- Safety ElderlySafety and efficacy of biologic therapies for the treatment of rheumatic and musculoskeletal diseases in elderly people.

14,00

Cucchiara Salvatore Sapienza University of Rome TRS-2018-00001662 1 - Rare DiseasesA RANDOMIZED DOUBLE-BLIND, MULTICENTER TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF A NEW ORAL VISCOUS BUDESONIDE FORMULATION IN PEDIATRIC PATIENTS WITH EOSINOPHILIC ESOPHAGITIS

14,00

Piccolo PasqualeTelethon Institute of Genetics and Medicine

TRS-2018-00001420 1 - Rare Diseases Prognostic factors for liver disease due to Z mutant alpha1-antitrypsin 14,00

Novelli GiuseppeUniversità degli Studi di Roma Tor Vergata - A.O.U Policlinico Universitario Tor Vergata

TRS-2018-00001513 1 - Rare DiseasesNovel phenotypes in LAMINopathies: a multicentre study for molecular diagnosis exploiting a high-throughput NGS strategy

14,00


Quaranta Luciano University of Brescia TRS-2018-00001509 4- Safety ElderlySelective laser trabeculoplasty (SLT) for deprescribing maximal tolerated medical therapy in elderly and ultra-elderly glaucoma patients: evaluation of the rate of progression of visual field damage and quality of life. (Selective Laser for Glaucoma Deprescribing: SLGD)

14,00

Mazzon EmanuelaIRCCS Centro Neurolesi "Bonino Pulejo"

TRS-2018-00001425 5 - AMR Role of IDO in Multi-Drug Resistant Airway Infections 14,25

D'Avanzo BarbaraIRCCS Istituto di Ricerche Farmacologiche Mario Negri

TRS-2018-00001439 4- Safety ElderlyEFFECT OF BRIEF PSYCHOTHERAPY ON DISCONTINUATION OF LONG-TERM ANTIDEPRESSANT MEDICATION IN THE ELDERLY

14,25

Eva Alessandra Istituto G. Gaslini TRS-2018-00001479 1 - Rare DiseasesA prospective study of Glycogen Storage Disease type 1a to identify circulating exosomal microRNA biomarkers.

14,25

Novelli AntonioOspedale Pediatrico Bambino Gesù


A retrospective and prospective public database on a 20-year follow-up from two Italian academic hospital settings collecting information on the natural course, biomarkers, clinical workup, molecular markers and disease persistence in a cohort of 100 children with primary and secondary paediatric thyroid cancer diagnosed before 18 years. A real-life comparative effectiveness prospective study on recombinant human thyrotropin use in paediatric thyroid cancer

14,25

Pantoni Leonardo"L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan

TRS-2018-00001261 1 - Rare Diseases Acetazolamide treatment to improve cognition in CADASIL patients 14,50

Cimaz Rolando GillesAzienda Ospedaliero - Universitaria Meyer

TRS-2018-00001564 2 - Pediatric DiseasesAnalysis of the remission potential of canakinumab as a first-line treatment of systemic juvenile idiopathic arthritis

14,50

Brunetti-Pierri Nicola Federico II University of Naples TRS-2018-00001326 1 - Rare Diseases Development of biomarkers and efficacy of Losartan in Myhre syndrome patients 14,50

Merli PietroIRCCS Ospedale Pediatrico Bambino Gesù

TRS-2018-00001755 2 - Pediatric DiseasesFirst-in-human, Italian academic Phase I-II Trial based on adoptive Chimeric Antigen receptor (CAR)-T cells specific for CD19 antigen in patients with relapsed/refractory B-cell Acute Lymphoblastic Leukemia (B-ALL) or B-cell Non-Hodgkin Lymphomas (B-NHL)

14,50

Lonardi Sara Istituto Oncologico Veneto IRCCS TRS-2018-00001779 1 - Rare DiseasesRandomized phase 2 of avelumab or avelumab plus cetuximab in advanced squamous cell carcinoma of the anal canal: a clinical and translational study

14,50

Ortona Elena Istituto Superiore di Sanità TRS-2018-00001394 3 - Gender MedicineA Gender Approach in Rheumatoid Arthritis management: identification and validation of sex-specific predictive and prognostic biomarkers in patients treated with TNF-inhibiting drugs

14,50

Luciani MatteoOspedale Pediatrico Bambino Gesù

TRS-2018-00001773 2 - Pediatric DiseasesStudy to address the safety and efficacy of recombinant tissue Plasminogen Activator off label use in a cohort of neonates and children with Acute Ischemic Stroke (AIS).

14,50

Vincenzi BrunoUniversità Campus Bio-Medico di Roma

TRS-2018-00001415 1 - Rare DiseasesIdentification of genetic PolymorphISms to predict drug Toxicity in soft tissue sarcoma patients treated with Adjuvant CHemOtherapy

14,50


Di Maio MassimoUniversità degli Studi di Torino, Dipartimento di Oncologia

TRS-2018-00001500 4- Safety ElderlyA systematic review and literature-based meta-analysis of the efficacy of immune checkpoint inhibitors in elderly patients with solid tumors: the IMAGE (IMmunotherapy and AGE) study

14,50

Di Marco Vito Università di Palermo TRS-2018-00001495 4- Safety ElderlyUTILITY AND BENEFIT OF DIRECT-ACTING ANTIVIRALS (DAAs) IN ELDERLY PATIENTS WITH HEPATITIS C VIRUS (HCV) LIVER DISEASE

14,50

Terzolo Massimo University of Turin TRS-2018-00001405 4- Safety ElderlyTreatment with the glucocorticoid receptor antagonist Mifepristone in Old patients with Subclinical Cushing syndrome and Arterial hypertension: a randomized, placebo-controlled crossover trial (trial MOSCA).

14,50

Snijders DeborahDipartimento Salute della Donna e del Bambino (SDB) Università degli Studi di Padova

TRS-2018-00001404 1 - Rare Diseases Can Ataluren restore ciliary activity in PCD patients by overcoming non-sense mutations? 15,00

Lanari MarcelloAOSP Bologna Sant'Orsola-Malpighi

TRS-2018-00001599 2 - Pediatric DiseasesSAFETY OF ALBUTEROL IN CHILDREN UNDER TWO YEARS OF AGE WITH WHEEZING: A SYSTEMATIC REVIEW WITH META-ANALYSIS

15,00

Gentile IvanAzienda Ospedaliera Universitaria - Università degli Studi di Napoli Federico II

TRS-2018-00001588 5 - AMRCorrelation between Pk/Pd parameters and clinical response in ICU patients undergoing therapy with echinocandins: a real-life multicentre study

15,00

Indolfi GiuseppeAzienda Ospedaliero Universitaria Meyer

TRS-2017-00001204 2 - Pediatric DiseasesA Real World, Observational, Retro-Prospective, Cohort Study on the Use of Direct-Acting Antivirals for Italian Children with Chronic Hepatitis C

15,00

D'Ascenzo FabrizioDivision of Cardiology, Città Della Salute e della Scienza, Turin

TRS-2018-00001572 3 - Gender Medicine6 vs. 24 months of antiplatelet therapy with new p2Y12 inhinitor in fEmale patieNTs presenting with ACS and treated with coronary stent impLantation: the YENTL a randomized controlled trial.

15,00

Del Sette MassimoEnte Ospedaliero Ospedali Galliera

TRS-2018-00001483 1 - Rare Diseases Cognitive Impairment and depression in Pediatric and Juvenile Stroke: CIPJS study 15,00

Ardissino GianluigiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Centro SEU

TRS-2018-00001729 2 - Pediatric Diseases Tailored eculizumab treatment for aHUS in children 15,00

Bilo GrzegorzIstituto Auxologico Italiano, IRCCS; Ospedale San Luca

TRS-2018-00001449 3 - Gender Medicine Hypertension treatment with aldosterone antagonist in obese female and male individuals. 15,00

Roti GiovanniOspedale Maggiore : Azienda Ospedaliero-Universitaria di Parma

TRS-2018-00001307 1 - Rare Diseases OVVERIDE CHEMORESISTANCE IN T CELL ACUTE LYMPHOBLASTIC LEUKEMIA 15,00

Russo GiuseppinaPoliclinico universitario G. Martino di Messina

TRS-2018-00001423 3 - Gender MedicineGender Differences in Effectiveness and Safety of New Drugs for Treatment of type 2 diabetes. Non-interventional prospective multicenter study

15,00

Pedone ClaudioUniversità Campus Bio-Medico di Roma

TRS-2018-00001253 4- Safety Elderly Effectiveness and safety of deprescribing in older people: a randomized clinical trial 15,00

Barone Adesi Francesco Università del Piemonte Orientale TRS-2018-00001475 4- Safety ElderlyRisk of type 2 diabetes mellitus in antidepressant users: employing a pharmacodynamic approach in a multiregional population-based cohort study.

15,00


Santucci Annalisa Università di Siena TRS-2018-00001371 1 - Rare DiseasesA monocentric, double-blind, crossover clinical study to assess the efficacy of weekly administration of low-dose methotrexate in patients with alkaptonuria

15,00

Raia Valeria University "Federico II" of Naples TRS-2018-00001633 1 - Rare DiseasesA phase 2 randomized, double blind, multi-center, placebo-controlled study to explore clinical effects of combined repurposed drugs in Cystic Fibrosis subjects with rare genotypes not responsive to current CFTR-targeted therapies.

15,00

Carta Mauro GiovanniUniversity of Cagliari, Depatment of Medical Sciences and Public Health

TRS-2018-00001566 4- Safety ElderlyExercise in Elderly people with Major depressive disorder and Metabolic or Cardiovascular Disease

15,00

Coppini Raffaele University of Florence TRS-2018-00001737 2 - Pediatric Diseases Pharmacological treatment of pediatric heart failure and cardiomypathies in Italy 15,00

Galli LuisaUniversity of Florence, Meyer Children's Hospital

TRS-2018-00001547 2 - Pediatric Diseases Paediatric drug resistant tuberculosis: a multi-centre observational study on efficacy and safety of second line off-label drugs in HIV-negative children

15,00

Consolo Filippo IRCCS Ospedale San Raffaele TRS-2018-00001581 4- Safety Elderly Is it safe to reduce intensity of antiplatelet therapy in elderly patients? 15,25

Picci Piero Istituto Ortopedico Rizzoli TRS-2018-00001655 1 - Rare DiseasesAn Open-label, Multi-center, Phase 2 Study of Denosumab in selected patient with Aneurysmal Bone Cyst (ABC), difficult to treat due to site or relapsed after conventional treatments.

15,25

Maiorana AriannaOspedale Pediatrico Bambino Gesù

TRS-2018-00001484 1 - Rare DiseasesEfficacy and Safety of Somatostatin-Analogues in Hyperinsulinism Hypoglycemia: an interventional, prospective randomized, open-label trial controlled with diazoxide

15,25

Casale MaddalenaUniversità degli studi della Campania "Luigi Vanvitelli"

TRS-2018-00001648 1 - Rare DiseasesNational Survey on the prevalence of morbidity and mortality due to Asplenia or Splenectomy in Rare Diseases through the Italian Network on Asplenia.

15,25

Marrocco Trischitta MassimI.R.C.C.S. Policlinico San Donato TRS-2018-00001246 3 - Gender MedicineEFFECT OF SODIUM NITRITE ON AORTIC STIFFNESS AND WAVE REFLECTIONS AFTERENDOVASCULAR ABDOMINAL AORTIC REPAIR

15,50

Provini Federica IRCCS-ISNB TRS-2018-00001602 4- Safety ElderlyLong-term efficacy of a specific training program for general practitioners to discontinue benzodiazepines in the elderly: a cluster randomized controlled trial

15,50

Colafati Giovanna StefaniaOspedale Pediatrico Bambino Gesu

TRS-2018-00001796 1 - Rare DiseasesFinding noninvasive MRI biomarkers in pediatric gliomas: clinical impact of diffusion kurtosis imaging, multiparametric MRI, radiomics and radiogenomics.

15,50

Serra GiuliaOspedale Pediatrico Bambino Gesù

TRS-2018-00001778 2 - Pediatric DiseasesEfficacy and safety of memantine as antimanic and mood-stabilizing medication for children and adolescents with Bipolar Disorder: a multi-center, randomized, double-blind, placebo-controlled clinical trial.

15,50

Saponara MaristellaPoliclinico Sant'Orsola-Malpighi, University of Bologna

TRS-2018-00001224 1 - Rare DiseasesA phase 2 study of temozolomide in advanced rare tumors with MGMT promoter methylation after failure of standard therapies

15,50

De Giacomo AndreaUniversità degli Studi di Bari "Aldo Moro"

TRS-2018-00001742 2 - Pediatric Diseases Oxytocin targeted therapies to address Autism Spectrum Disorders¿ core symptoms 15,50


Tagliaferri Pierosandro Università Magna Graecia TRS-2018-00001288 3 - Gender MedicineGender based pharmacogenomic analysis of tyrosine kinase inhibitors in lung cancer and of proteosome inhibitors in multiple myeloma

15,50

De Benedetti FabrizioIRCCS Ospedale Pediatrico Bambino Gesù

TRS-2018-00001451 1 - Rare DiseasesNovel genetic and immune biomarkers of diagnosis, risk, severity and response to treatment of macrophage activation syndrome (MAS) and secondary haemophagocytic lymphohistiocytosis (sHLH): a prospective observational study

16,00

Di Meco FrancescoFoundation I.R.C.C.S Neurological Institute Carlo Besta, Milan

TRS-2018-00001731 1 - Rare DiseasesBlood-brain barrier opening for mitoxantrone delivery in recurrent glioblastoma with Magnetic Resonance guided Focused Ultrasound and ultrasound contrast agents: a single center pilot study to assess safety and feasibility

16,00

Menichetti FrancescoAzienda Ospedaliera Universitaria Pisana

TRS-2018-00001498 5 - AMRClinical impact of an educational intervention on antibiotic prescribing in patients with Gram-negative bacilli bacteremia: a multicenter cluster randomized controlled trial

16,00

Carugati Manuela Ospedale San Gerardo TRS-2018-00001266 5 - AMRAntimicrobial stewardship among solid organ transplant recipients (ASSOT): a multicenter quasi-experimental study.

16,00

Giustozzi MichelaDepartment of Internal and Emergency Medicine-Stroke Unit

TRS-2018-00001707 4- Safety ElderlyClinical benefit of anticoagulant Vs no anticoagulant treatment in patients aged 90 or older with atrial fibrillation in real-world clinical practice.

16,00

Giaquinto CarloDepartment of women and Child Health University of Padova

TRS-2018-00001473 5 - AMRDEVELOPMENT AND IMPLEMENTATION OF PEDIATRIC IN-HOSPITAL ANTIMICROBIAL STEWARDSHIP PROGRAM THROUGH PEDIATRIC CLINICAL PATHWAYS AND PERIODICAL PRESCRIPTION FEEDBACK

16,00

Vinciguerra Paolo Humanitas Research Hospital TRS-2018-00001736 1 - Rare Diseases New Riboflavin applications in CXL (CORNEAL CROSSLINKING). 16,00

Stocchi Fabrizio IRCCS San Raffaele Pisana TRS-2018-00001364 4- Safety ElderlyEfficacy and safety study of use Quetiapine for patients with Parkinson¿s disease psychosis: a randomised, double-blind, placebo-controlled trial.

16,00

Bonati Maurizio

Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"

TRS-2018-00001710 2 - Pediatric DiseasesSafety and Efficacy of on-Label and Off-label Psychotropic drugs in children and adolescents with mental disorders. (SELOPsy study)

16,00

Ciceri Fabio Ospedale San Raffaele TRS-2018-00001631 5 - AMRImpact of microbiome characterization and fecal transplant on the risk of infections by multi-drug-resistant (MDR) bacteria after allogeneic hematopoietic stem cell transplantation (HSCT).

16,00

Scuteri Angelo Policlinico Tor Vergata TRS-2018-00001429 3 - Gender MedicineGender-specific efficacy of canrenone on arterial aging and metabolic parameters in a cohort of obese middle-age subjects with elevated blood pressure

16,00

Talora Claudio Sapienza University of Rome TRS-2018-00001241 1 - Rare Diseases Antioxidant therapy as an effective therapeutic strategy for Hailey-Hailey-Disease 16,00


Blandizzi Corrado

Sezione di Farmacologia e Farmacovigilanza - Dipartimento di Medicina Clinica e Sperimentale - Università di Pisa

TRS-2018-00001741 3 - Gender MedicineThe risk of perinatal events in newborn after antidepressant exposure during pregnancy, experiencing the ¿AMALTEA¿ app from data collection to pharmacological consultation ¿ the AMALTEA study

16,00

De Santis MarcoUniversità Cattolica del Sacro Cuore

TRS-2018-00001555 1 - Rare DiseasesPrimary Cytomegalovirus infection in the first and second trimester of pregnancy and therapy with Valacyclovir: prevention of vertical transmission and of fetal-neonatal injury. The VALCYPRE Study.

16,00

Carbone Marco Università di Milano-Bicocca TRS-2018-00001257 1 - Rare DiseasesA Precision Medicine approach to understand the basis of treatment failure in Primary Biliary Cholangitis (PBC)

16,00

Chieffo Alaide San Raffaele Hospital TRS-2018-00001223 3 - Gender MedicineDiagnosis and treatment of chronic ischemic syndromes in patients with non-obstructive coronary artery disease

16,25

Meocci PatriziaMeyer Children's University Hospital - Florence

TRS-2018-00001445 4- Safety ElderlyEFFICACY AND SAFETY OF CARDIOVASCULAR DRUGS IN OLDER PEOPLE WITH DEMENTIA RECEIVING HOME CARE ASSISTANCE

16,50

Barcellini WilmaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

TRS-2018-00001698 1 - Rare DiseasesComparison of the efficacy and safety of standard versus low-dose rituximab in warm autoimmune hemolyticanemia and cold agglutinin disease

16,50

Napoleone EttoreFP-MCRN (Family Pediatricians-Medicines for Children Research Network)

TRS-2018-00001260 2 - Pediatric DiseasesDiagnostic tools and training strategies for improving the appropriate use of Antibiotics among childhood population in extra hospital settings to reduce both the Ab resistance and ADRs: a RCT.

16,50

Belardelli FilippoIstituto di Farmacologia Traslazionale (CNR)

TRS-2018-00001763 3 - Gender MedicineCombining peptide vaccination with discontinuous interferon-alpha alone or together with a single dose of cyclophosphamide to prevent recurrence and identify gender-specific biomarkers in resected stage III melanoma patients

16,50

Hollander LitalIstituto di ricerche farmacologiche Mario Negri

TRS-2018-00001267 1 - Rare DiseasesPembrolizumab and Trabectedin in advanced pretreated malignant pleural mesothelioma ¿ PETRA Study

16,50

Sangiorgi Luca Rizzoli Orthopaedic Institute TRS-2018-00001328 1 - Rare Diseases Finding New Evidence on Multiple Osteochondromas 16,50

Vania Andrea Sapienza Università di Roma TRS-2018-00001565 2 - Pediatric Diseases

A multicenter controlled clinical Study to Evaluate efficacy and safety of CHOLecalciferol supplementation with diet and physical activity in improving cardio-metabolic and skeletal profile in female and male pediatric prepubertal subjects affected by overweight and/or Obesity.

16,50

Arca MarcelloSapienza University of Rome Dept of Internal Medicine and Allied Sciences

TRS-2018-00001398 1 - Rare DiseasesEfficacy of lomitapide in reducing cardiovascular outcomes in patients with homozygous familial hypercholesterolemia (HoFH): data from a real-world analysis

16,50

Di Zazzo AntonioUniversità Campus Bio-Medico di ROma

TRS-2018-00001723 2 - Pediatric DiseasesNew Topical administration of 1mg/mL Acetylsalicylic acid in management of allergic Vernal keratoconjunctivitis

16,50

Cardile Venera University of Catania TRS-2018-00001542 1 - Rare DiseasesCORRELATION BETWEEN GENOTYPE, PHENOTYPE AND BIOMARKERS IN KRABBE DISEASE: ISTITUTION OF AN ITALIAN REGISTER

16,50

Zignego Anna Linda University of Florence TRS-2018-00001447 1 - Rare DiseasesUse of rituximab to improve the outcome of antiviral therapy for HCV-associated mixed cryoglobulinemia vasculitis

16,50


Ferrante Pasquale University of Milano TRS-2018-00001352 1 - Rare DiseasesThe role of cytotoxic T lymphocytes function against Merkel Cell Carcinoma: an observational study

16,50

Marchese CinziaSapienza University of Rome - Umberto I Polyclinic

TRS-2018-00001418 1 - Rare DiseasesPhase-II monocentric open-label study on a novel vaginoplasty technique using autologous vaginal mucosal layers in patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: anatomical and functional outcomes

16,75

Iacoviello Licia Fondazione Neuromed TRS-2018-00001553 4- Safety ElderlyThe COmbined MEditerranean diet and STAtins for secondary cardiovascular risk prevention TRIAL

17,00

Papi MassimilianoFondazione Policlinico Gemelli-Università Cattolica del Sacro Cuore

TRS-2018-00001784 4- Safety ElderlyGRAphene detector of CIrculating microRNAs as a Leading high-sensitive tool for fracture prevention and therapy follow up in osteoporosis

17,00

Greco Massimiliano Humanitas Research Hospital TRS-2018-00001630 4- Safety ElderlySAFEty of anesthesia and Ancillary perioperative druG in the Elderly patient: A Network Meta-analysis of Mixed Treatment Comparisons (SAFE-AGE study)

17,00

Maselli Roberta Humanitas Research Hospital TRS-2018-00001463 1 - Rare DiseasesRisk of Microbial Translocation in patients undergoing Per-Oral Endoscopic Myotomy (POEM) for Achalasia: Antibiotic Prophylaxis vs Short-therapy

17,00

Stefanini Giulio Giuseppe IRCCS Istituto Clinico Humanitas TRS-2018-00001525 4- Safety Elderly

Tailoring Antithrombotic ReGimEns in ocTogenarians with atrial fibrillation and coronary artery disease treated with percutaneous revascularization: a randomized comparison of low-dose ticagrelor versus dual antiplatelet therapy with aspirin and clopidogrel on top of oral anticoagulation

17,00

Sciuto RosaIRCCS Regina Elena National Cancer Institute

TRS-2018-00001717 1 - Rare DiseasesIn vivo biological characterization of NET using 64CU -DOTATOC PET /CT: a novel potential theranostic agent.

17,00

Raponi MassimilianoOspedale Pediatrico Bambino Gesù

TRS-2018-00001685 5 - AMRPromoting appropriateness of antibiotic prescriptions in children's hospitals: a collaborative multisite prospective study

17,00

Vaccaro Olga "Federico II" University of Naples TRS-2018-00001301 3 - Gender Medicine

Gender differences in the response and the benefit/risk profile of two antihyperglycemic drugs with different mechanisms of action: enhancement of insulin secretion (sulfonylureas) vs improvement of insulin action (pioglitazone) Protocol version 1 - January 30, 2018

17,50

Garavelli Livia AUSL IRCCS Reggio Emilia TRS-2018-00001691 1 - Rare DiseasesClinical Management of Mowat-Wilson Syndrome: Creation of a Disease Registry and of Specific Growth Charts for Affected Children and Youths

17,50

Caproni Marzia Azienda USL Toscana Centro TRS-2018-00001494 1 - Rare DiseasesLong-term treatment effectiveness and safety in patients with bullous pemphigoid through the development of the Bullous Pemphigoid patient-Registry (BPReg)

17,50

Fisher Alessandra DaphneDepartment of Experimental, Clinical and Biomedical Sciences, University of Florence

TRS-2018-00001272 2 - Pediatric Diseases Safety Study of Triptorelin in Adolescents with Gender Dysphoria/ Gender Incongruence. 17,50

Milito CinziaDepartment of Molecular Medicine Sapienza University of Rome

TRS-2018-00001708 5 - AMRObservational cohort prospective multicenter study on antibiotic use and on antibiotic resistance of S. pneumoniae and H. influenzae strains colonizing nasopharyngeal mucosa in patients with Primary Immune Defects

17,50


Ardizzone SandroFatebenefratelli e Oftalmico Hospital ASST Fatebenefratelli Sacco

TRS-2018-00001783 4- Safety Elderly Deprescribing chronic proton pump inhibitor (PPI) use in elderly patients 17,50

Seregni EttoreFondazione IRCCS Istituto Nazionale dei Tumori Milano

TRS-2018-00001646 1 - Rare DiseasesPhase II Study of 177Lu-DOTATATE therapy in recurrent or progressive meningioma patients.

17,50

Fattorini Annalisa IRCCS Ospedale San Raffaele TRS-2018-00001706 4- Safety Elderly Management Of Dabigatran Etexilate Under LAboratory TEsting in Atrial Fibrillation 17,50

ridolfi laura IRST IRCCS TRS-2018-00001251 4- Safety ElderlyCombination Immunotherapy of a dendritic cell based vaccine and nivolumab in elderly metastatic melanoma patient: a phase 1 study.

17,50

Harari Sergio Ospedale San Giuseppe TRS-2018-00001428 1 - Rare DiseasesIs it Possible to Predict the Evolution of Lymphangioleomyomatosis? A Prospective Radiological, Functional and Biomolecular Study

17,50

Azzari Chiara Università degli Studi di Firenze TRS-2018-00001455 2 - Pediatric DiseasesThree or four dose schedule for hexavalent (DTP-HBV-IPV-Hib) vaccination in preterm babies? Risk of pertussis and Haemophilus influenzae type b in preterm babies vaccinated with 3 doses of hexavalent vaccines.

17,50

Procino Giuseppe University of Bari TRS-2018-00001281 1 - Rare DiseasesNovel Off-label Application of Mirabegron (Betmiga) to cure X-linked Nephrogenic Diabetes Insipidus

17,50

Giacomelli Roberto University of L'Aquila TRS-2018-00001556 1 - Rare DiseasesShort-term anakinra as first-line disease-modifying therapy in adult onset Still¿s disease: a proof-of-concept multicenter double blind randomized controlled trial

17,50

Merli FrancescoAzienda Ospedaliera Arcispedale Santa Maria Nuova - IRCCS - Ematologia


Prephase treatment with prednisone +/- Vitamin D supplementation followed by reduced-dose immunochemotherapy in Elderly non-FIT patients with Diffuse Large B-Cell Lymphoma (DLBCL). A randomized, open label, phase III study by Fondazione Italiana Linfomi.

18,00

Davoli MarinaDepartment of Epidemiology Regional Health Service, Regione Lazio, ASL Roma 1

TRS-2018-00001789 3 - Gender MedicineSAFETY AND RISKS ASSOCIATED WITH NEW AND OLD PHARMACOLOGICAL TREATMENTS FOR PSORIASIS IN PREGNANCY AND LACTATION: A SYSTEMATIC REVIEW

18,00

Di Martino MirkoDepartment of Epidemiology, ASL Roma 1, Lazio Region, Italy. Division of Outcome Research

TRS-2018-00001329 5 - AMRImproving the rational use of antibiotics in pediatric outpatients: the impact of a multidimensional, public health intervention.

18,00

De Martino Maria CristinaDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli "Federico II"


Brain morpho-functional MRI, neurological and neuromuscular function, psychological profile, and cognitive function correlates in hypogonadal men with rare hypothalamus-pituitary-testis axis disorders: a comparative study on the effects of different testosterone formulations

18,00

Belleudi ValeriaDipartimento Epidemiologia del S.S.R. - ASL Roma 1 - Regione Lazio

TRS-2018-00001587 2 - Pediatric DiseasesUtilization, effectiveness, safety and costs of Palivizumab in infants according to gestational age: a record-linkage, multi-database, multi-regional, observational cohort study.

18,00

Federici AugustoDivisione Ematologia e Medicina Trasfusionale ASST-Fatebenefratelli-Sacco

TRS-2018-00001391 1 - Rare Diseases"MAnagement of Gastro-Intestinal bleeds (GIB) with VWF Concentrates in von Willebrand Inherited and Acquired patients: retrospective and prospective study '18."

18,00


Castagnola Elio Istituto Giannina Gaslini TRS-2018-00001709 2 - Pediatric DiseasesEvaluation pharmacokinetics/pharmacodinamics (PK/PD)of antibiotics in critically ill children

18,00

Parri NiccolòMeyer University Children's Hospital

TRS-2018-00001786 2 - Pediatric DiseasesA prospective clinical trial to evaluate the safety and efficacy of Contrast Enhanced UltraSound (CEUS) in pediatric blunt abdominal trauma

18,00

Martinelli DiegoOspedale Pediatrico Bambino Gesu', IRCCS

TRS-2018-00001794 1 - Rare DiseasesSafety and Efficacy of EPI-743 for the Treatment of Patients with RARS2 defect syndrome (Pontocerebellar Hypoplasia Type 6)

18,00

Pieri Marina Ospedale San Raffaele TRS-2018-00001343 4- Safety ElderlyAnesthesia depth levels and postoperative DeliRium in agEd pAtients: a prospective double-blinded Multicenter Study

18,00

Mercuri Eugenio Maria Università Cattolica TRS-2018-00001703 1 - Rare DiseasesClinical follow up of children and adults with Spinal muscular atrophy treated with Nusinersen 18,00

Andreoli Laura University of Brescia TRS-2018-00001727 3 - Gender MedicineImplementing Knowledge and Communication about the Use of Drugs during Pregnancy in Women with Autoimmune Rheumatic Diseases: a multicenter, national-based, prospective cohort study.

18,00

D'amico Emanuele University of Catania TRS-2018-00001616 1 - Rare DiseasesHypermetabolism status in persons with Primary Progressive Form of Multiple Sclerosis: a case control study

18,00

Giuliano Mario AOU Federico II TRS-2018-00001574 1 - Rare DiseasesMulitcenter open label, phase II trial of oral Vinorelbine and Anakinra as second-line treatment for L-group Histiocytoses.

18,50

Tronci EnricoComputer Science Department - Sapienza University of Rome

TRS-2017-00001203 1 - Rare DiseasesA complete set of in-vivo validated patient computational models to support in-silico drug re-purposingfor rare diseases: the NLSDM case.

18,50

Savastano Silvia

Federico II University, Dipartimento di Medicina Clinica e Chirurgia, Unità di Endocrinologia

TRS-2018-00001419 3 - Gender Medicine

GEN.I.O.GENder-difference In Obesity. A multicenter study to evaluate differences in efficacy and safety of Saxenda and Mysimba in a female and male population.

18,50

Leone Francesco FPO IRCCS Candiolo TRS-2018-00001345 4- Safety ElderlyFluoropyrimidine Induced cardioToxicity in colorectal cancer: a multidimensioNal Elderly patient Safety aSsessment

18,50

Sarzani Riccardo

Internal Medicine and Geriatrics, "Hypertension Excellence Centre" of the European Society of Hypertension, IRCCS-INRCA, University "Politecnica delle Marche"

TRS-2018-00001642 4- Safety ElderlyHYpertension in the Very Elderly: longitudinal evaluation of the 24-hour blood pressure profile, drug therapy, comorbidities and individual performance status ¿ The Italian Registry

18,50

Banzi RitaIRCCS Mario Negri Institute for Pharmacological Research

TRS-2018-00001270 2 - Pediatric DiseasesEfficacy and safety of pharmacological interventions for the treatment of multiple sclerosis in children and adolescents: a systematic review of published and unpublished studies

18,50

Pietrangelo AntonelloAzienda Ospedaliero Universitaria Policlinico di Modena

TRS-2017-00001188 1 - Rare DiseasesEfficacy and safety of the association of the oral iron chelating agents deferasirox and deferiprone in beta thalassemic patients: a multicenter open label trial.

18,50


Becattini CeciliaMedicina Interna e Cardiovascolare - Università di Perugia

TRS-2018-00001379 4- Safety ElderlyBenefit-risk profile of direct oral anticoagulants and vitamin K antagonists in patients with atrial fibrillation and cancer

18,50

Drago LorenzoUniversità degli Studi di Milano - Dipartimento di Scienze Biomediche per la Salute

TRS-2018-00001611 5 - AMRprOactive surveillanCe data gatheRing and analysis to sensitize about Antibiotic prescription inappropriateness and resulting resistance in local General Practice setting

18,50

Scotti Lorenza University of Milano-Bicocca TRS-2018-00001694 4- Safety Elderly Prevention of dementia by antihypertensive drug use: a meta-analysis 18,50

Sorio Claudio University of Verona TRS-2018-00001562 1 - Rare DiseasesIntestinal organoids and optical imaging technology for the prediction and follow-up of the functional response to CFTR potentiators and correctors

18,50

Mandala Mario ASST Papa Giovanni XXIII TRS-2018-00001469 4- Safety ElderlyAnti pneumococcal and anti influenza vaccine prophylaxis in elderly cancer patients receiving anti-PD-1 antibodies: a prospective phase 2 randomized study

19,00

Leoni Olivia ATS Insubria TRS-2018-00001795 4- Safety ElderlyPolypharmacy and the risk of Potentially Inappropriate Prescriptions (PIPs) in community dwelling olderpatients

19,00

Bignami ElenaAzienda Ospedaliero-Universitaria di Parma

TRS-2018-00001657 4- Safety ElderlySevoflurane for the prevention of post-operative cognitive dysfunction in elderly patients undergoing cardiac surgery

19,00

Poggio Paolo Centro Cardiologio Monzino IRCCS TRS-2018-00001390 3 - Gender MedicineA multicentre prospective study on subclinical aortic valve disease: effects of statins on oxidative stress and inflammation in aortic valve sclerosis patients requiring surgical myocardial revascularization.

19,00

Arrigo AlessandroDepartment of Ophthalmology, University Vita-Salute San Raffaele

TRS-2018-00001772 1 - Rare Diseases Multimodal and functional assessment in Choroideremia. 19,00

Messori Andrea ESTAR Toscana TRS-2018-00001284 1 - Rare DiseasesProphylaxis of bleeding in patients with hemophilia A and high-titer inhibitors: systematic review of the published evidence and determination of cost-effectiveness (EMI-HEMO)

19,00

Perricone Roberto Fondazione Policlinico Tor Vargata TRS-2018-00001544 1 - Rare DiseasesThe registry of patients with hereditary angioedema to derive real life data for determining the cost/efficacy ratio of therapies for treatment or prevention of disease epsiodes in patients with genetic and acquired C1 inhibitor deficiency.

19,00

Pisani Antonio Fondazione Santa Lucia, IRCCS TRS-2018-00001294 1 - Rare DiseasesMobile Health Technology for Genomics-Based Personalized Therapy in Young-Onset Parkinson's Disease

19,00

Capra ValeriaIstituto G.Gaslini, U.O.C. Neurochirurgia

TRS-2018-00001327 3 - Gender Medicine Prevention of Neural Tube Defects by Inositol: a pilot randomised controlled study 19,00

Gattorno Marco Istituto Giannina Gaslini TRS-2018-00001645 2 - Pediatric Diseases ANAKINRA IN DIFFICULT TO TREAT CHIDREN WITH RECURRENT PERICARDITIS 19,00

Pace Andrea Istituto Regina Elena TRS-2018-00001323 1 - Rare DiseasesRepurposing the energy blocker Lonidamine as a therapeutic agent in the combined treatment of newly diagnosed Glioblastoma Multiforme

19,00

Picardo Sergio GiuseppeOpedale Pediatrico Bambino Gesù, Roma

TRS-2018-00001604 2 - Pediatric DiseasesOPIOID MANAGEMENT by PHARMACOGENETICS and POPULATION PHARMACOKINETICS for ANALGESIA with LEAST OPTIMAL SCALING

19,00


Ferraresi VirginiaRegina Elena National Cancer Institute

TRS-2018-00001409 1 - Rare DiseasesActionable genomes in Rare cancers: hub-and-spoke therapy assignment by NGS and liquid biopsy

19,00

Mussini CristinaUniversità degli Studi di Modena e Reggio Emilia

TRS-2018-00001501 5 - AMRMultifaceted study on antimicrobial stewardship and infection control in long term care facilities

19,00

Emmi Giacomo University of Firenze TRS-2018-00001668 1 - Rare DiseasesImmunosuppressive treatment for Eosinophilic Granulomatosis with Polyangiitis (EGPA, formerly Churg-Strauss syndrome) with traditional DMARDs and biologic DMARDs: a meta-analysis

19,00

Colombo CinziaIRCCS Istituto di Ricerche Farmacologiche Mario Negri

TRS-2018-00001724 4- Safety ElderlyEffects of de-prescribing of benzodiazepines and z-drugs for insomnia in older people: a non-randomized interventional study in a primary care setting.

19,25

Pinto Carmine AUSL/IRCCS di Reggio Emilia TRS-2018-00001684 4- Safety ElderlyNIVI-Study: Italian observational study of Nivolumab treatment in metastatic non-small-lung cancer elderly patients with hepatitis B/C (HBV/HCV) or human immunodeficiency virus (HIV) infection in the real clinical practice.

19,50

Starace FabrizioDSMDP AUSL Modena & Società Italiana di Epidemiologia Psichiatrica


Optimising the use of antidepressants and antipsychotics in late-life depression: systematic review of randomised and observational evidence and development of national evidence-based GRADE recommendations.ADAPTED-IG: AntiDepressant and AntiPsychotic Treatment of Elderly with Depression: developing Italian Guidelines

19,50

Boletta Alessandra IRCCS Ospedale San Raffaele TRS-2018-00001610 1 - Rare DiseasesEstablishment of the Italian Registry of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Characterization of Metabolic alterations: a large multi-center effort under the aegis of the Italian Society of Nephrology

19,50

Cataldo Maria AdrianaIstituto Nazionale per le Malattie Infettive "L. Spallanzani"

TRS-2018-00001589 5 - AMREffect of Fluoroquinolone-based Antimicrobial Stewardship on Clostridium difficile Infection (CDI) in Long-term care Facilities.

19,50

Proietti Marco Sapienza-University of Rome TRS-2018-00001280 4- Safety ElderlyEvaluation of Comorbidity and Adverse Outcomes in Older Patients taking Oral Anticoagulant Therapy for Atrial Fibrillation

19,50

Ruospo MarinellaUniversity of Bari - Department of Emergency and Organ Transplant

TRS-2018-00001528 4- Safety ElderlyImpact of glucose-lowering drugs on mortality and cardiovascular events for special populations with type 2 diabetes: Network meta-analysis (NETWORK-DM)

19,50

Gennari LuigiUniversity of Siena - DEPT of Medicine Surgery and Neurosciences

TRS-2018-00001490 4- Safety ElderlyEfficacy and Safety of Antiresorptive Therapies for Treating osteoporosis in Older patients (ESATTO Study): short term regimens and implications of continuing vs. stopping treatment in long term users

19,50

Monaco Fabrizio Fondazione Centro San Raffaele TRS-2018-00001619 4- Safety ElderlyA network meta-analysis of randomized trials on all anesthesia techniques in cardiac surgery of the elderly

20,00

Tshomba Yamume IRCCS Ospedale San Raffaele TRS-2018-00001435 4- Safety Elderly Statins to reduce stroke in endovascular surgery in elderly patients. A meta-analysis. 20,00

Nobile MariaIstituto Scientifico IRCCS 'E. Medea'

TRS-2018-00001372 2 - Pediatric DiseasesAripiprazole and Risperidone in Pediatric patients with Autism-spectrum disorders: a head-to-head RCT-DB evaluating the efficacy on Irritability and Quality of life

20,00


Ferracini Riccardo Ospedale Policlinico San Martino TRS-2018-00001448 4- Safety ElderlyMultiple Injections of Autologous Adipose derived-Stromal Vascular Fraction for the treatment of hip and knee osteoarthritis of the elderly

20,00

Forni Gianluca Ospedale Galliera TRS-2018-00001605 1 - Rare Diseases Creation of a DataBase for the "Italian Network of Thalassemia and HEMoglobinopathies" 20,00

Giannini FrancescoUnit of Cardiovascular Interventions, IRCCS San Raffaele Scientific Institute

TRS-2018-00001570 3 - Gender Medicine Incidence, Correlates and Outcomes of Transcatheter Aortic Valve Thrombosis 20,00

Bernabei RobertoUniversità Cattolica del Sacro Cuore

TRS-2018-00001546 4- Safety Elderly Metformin Administration to contraST the progrEssion of fRailty in the elderly 20,00

Bravaccio Carmela Università Federico II TRS-2018-00001443 2 - Pediatric DiseasesRisperidone use in Autism Spectrum Disorder associated with Down syndrome: challenging disruptive behaviours in a rare and hard to treat population

20,00

Ferrante Fulvio Asl Frosnone-UOC Farmacia TRS-2018-00001454 3 - Gender MedicineSEX-GENDER DIFFERENCE IN THE INNOVATIVE CARDIOVASCULAR DRUGS: EVALUATION OF THE RISK AND ACTIVE SURVEILLANCE

20,50

Filosto Massimiliano ASST Spedali Civili TRS-2018-00001689 1 - Rare Diseases

ASSESSING THE ROLE OF LEUKOCYTE MEMBRANE MARKERS FOLLOWING INTRAVENOUS IMMUNOGLOBULINE TREATMENT IN MODULATING THE RESPONSE TO THERAPY IN CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY AND GUILLAIN- BARRE' SYNDROME: A PROSPECTIVE STUDY

20,50

Frassoldati AntonioAzienda Ospedaliero-Universitaria di Ferrara

TRS-2018-00001634 4- Safety ElderlyInfluence of comorbidities and concomitant medications on the adherence to treatment with CDK4/6 inhibitors plus hormones for ER+/HER2- metastatic breast cancer in women > 65 years old. The COMETA observational study.

20,50

Giommoni Elisa SC Oncologia Medica AOU Careggi TRS-2018-00001700 1 - Rare DiseasesMulticentre, randomised phase II trial of Cisplatin and Gemcitabine in association with Nivolumab versus chemotherapy alone as first-line treatment in advanced biliary tract cancer

20,50

Poluzzi ElisabettaUniversity of Bologna - Department od Medical and Surgical Sciences

TRS-2018-00001355 4- Safety ElderlyRisk of falls in the Italian Elderly: an experimental model to identify the role of drugs and drug-drug interactions and to develop relevant strategies to monitor the quality of drug use

20,50

Furlan RaffaelloHumanitas University and Humanitas Research Hospital

TRS-2018-00001725 1 - Rare DiseasesEffects of immunotherapy on plasma anti-nAChR antibodies, autonomic profile, symptoms intensity and RNA expression in patients affected by pure autonomic failure (PAF).

21,00

Gregori Silvia Adriana Ospedale San Raffaele TRS-2018-00001621 2 - Pediatric DiseasesTo define the impact of the immune response to missing enzymes on the efficacy of enzyme replacement therapy (ERT) in patients with lysosomal storage disorders.

21,00

Chiodini PaoloUniversity of Campania "Luigi Vanvitelli"

TRS-2018-00001721 4- Safety ElderlyAbiraterone acetate in chemo-naive metastatic castration resistent prostate cancer patients: systematic review and meta-analysis of the real life setting literature.

21,00

Minozzi Ruffini Silviamaria Unversità degli Studi di Milano TRS-2018-00001302 5 - AMRShort versus long course oral antibiotic therapy for the treatment of infections in the outpatient settings: an overview of systematic reviews.

21,00

Maggio Marcello Università di Parma TRS-2018-00001738 4- Safety ElderlyMultidomain frailty in senior community residents: detection, proactive intervention and deprescribing

21,50


Mura GioiaAzienda Ospedaliero Universitaria di Cagliari

TRS-2018-00001489 4- Safety ElderlyEfficacy of Physical Activity programs to reduce the pharmacological burden of chronic diseases in the elderlies: a systematic review and meta-analysis.

21,50

Buoli Massimiliano

Department of Psychiatry, University of Milan, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico

TRS-2017-00001206 3 - Gender MedicineA double-blind randomized study of escitalopram versus vitamin D3 in Perinatal Depression: which biological markers are associated with pharmacological response?

21,50

Barbic Franca Humanitas Research Hospital TRS-2018-00001704 3 - Gender Medicine

Role of Ivabradine in Promoting Adherence of Individualized Physical Training and its Effectiveness in Women and Men Affected by Postural Orthostatic Tachycardia Syndrome (POTS). An overall Focus on Gender Differences in Cardiovascular Autonomic Profile, Quality of Life and Work Ability.

21,50

Savasta SalvatoreIRCCS Policlinic San Matteo Foundation

TRS-2018-00001674 2 - Pediatric DiseasesA Multicentre Single Arm Phase II Trial Of Intravenous Immunoglobulins (IVIG) For Moderate-Severe Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)

21,50

D'Angelo SalvatoreAOR San Carlo di Potenza - Rheumatology Department of Lucania

TRS-2018-00001410 1 - Rare DiseasesDENOSUMAB FOR THE TREATMENT OF SYSTEMIC SCLEROSIS-RELATED OSTEOPOROSIS (DESSO): AN OBSERVATIONAL SAFETY STUDY

22,00

Cabrini Luca Fondazione Centro San Raffaele TRS-2018-00001627 4- Safety ElderlyA network meta-analysis of randomized trials performed in intensive care units on the effects of sedative agents on mortality in elderly

22,00

Garaventa Alberto G. Gaslini Institute TRS-2018-00001426 1 - Rare DiseasesMolecular biomarkers of the response to induction chemotherapy: assessment of exosomal miRNA in High-Risk (HR) Neuroblastoma patients' blood

22,00

Ceroni MauroIRCCS "C. Mondino" National Neurological Isntitute

TRS-2018-00001693 1 - Rare DiseasesStudy protocol of a phase II, randomized, double blind, placebo controlled, multicenter clinical trial testing Perampanel for treatment of amyotrophic lateral sclerosis (ALS)

22,00

Campione Elena Tor Vergata General Hospital TRS-2018-00001618 4- Safety ElderlyStratified Medicine for Elderly Psoriatic patients: selection and application of new generation drugs upon genomic and immunologic profiling

22,00

Galli JessicaUniversity of Brescia, Dep. of Clinical and Experimental Sciences

TRS-2018-00001659 3 - Gender MedicineLong-term neurodevelopmental outcome of children exposed in utero to heparin, glucocorticoids and anti-rheumatic drugs

22,00

Fabiano ValentinaUniversity of Milan, ASST-FBF-Sacco, Vittore Buzzi Children's Hospital

TRS-2018-00001471 2 - Pediatric DiseasesA new extemporary compounded orodispersible formulation of clobazam for treatment of epilepsy in children: a pilot study on acceptability and tolerability and a pharmacokinetic evaluation.

22,00

Minisola Salvatore Sapienza University of Rome TRS-2018-00001593 4- Safety ElderlyProspective study on the adherence to alendronate in elderly patients on multiple concomitant treatments and effect of intensive monitoring vs long-term follow-up

22,50

Corrao Salvatore Università degli studi di Palermo TRS-2018-00001580 4- Safety ElderlyA Nursing-centered MUltidimensional aSsessment of Elderly internal medicine outpatient with comorbidities: the M.U.S.E. project

22,50

Cremonesi Paolo TRS-2018-00001770 4- Safety Elderly Drugs and falls in older people: experimentation of therapeutical revision protocols 22,75


Di Pasquale Giuseppe Azienda USL di Bologna TRS-2018-00001549 4- Safety ElderlyA stepped wedge cluster randomised controlled trial to evaluate the efficacy and safety of a complex intervention to reduce polytherapy in elderly patients admitted to acute wards

23,00

Dell'Osso BernardoFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

TRS-2018-00001644 4- Safety ElderlyA RANDOMIZED CONTROLLED FACTORIAL STUDY ON DEPRESCRIBING BENZODIAZEPINES AND OTHER HYPNOTIC DRUGS IN ITALIAN PATIENTS WITH LATE-LIFE DEPRESSION: FEASIBILITY, EFFICACY, SAFETY AND EPIGENETIC CHANGES

23,50

Bonassi Stefano IRCCS ASam Raffaele Pisana TRS-2018-00001521 4- Safety ElderlyMonitoring the Efficacy and Safety of Polypharmacy in Elderly Male and Female population in different settings

23,50

Raschi Emanuel University of Bologna TRS-2018-00001453 4- Safety ElderlyComparative safety and effectiveness of Direct Oral AntiCoagulants in the eldeRly: a systemAtic review and NetworK meta-analysis of real-world evidence

23,50

Rizzo Maria RosariaUniversity of Study of Campania "Luigi Vanvitelli"

TRS-2018-00001293 4- Safety ElderlyComparison between non¿vitamin K antagonist oral ANticoagulants (NOACs) and warfarin for the prevention of COgnitive DEcline in elderly patients with non-valvular atrial fibrillation (NVAF): a pilot randomized open-label controlled trial.

23,50

Di Domenicantonio RiccardoDepartment of Epidemiology, ASL Roma 1, Lazio Region

TRS-2018-00001607 3 - Gender MedicineUtilization and safety of pharmaceutical treatments in women with chronic inflammatory bowel diseases during pregnancy: multiregional population-based cohort study on maternal and birth outcomes from health information systems data

24,00

Rosano Giuseppe MC IRCCS San Raffaele Roma TRS-2018-00001647 4- Safety ElderlyAssociation of ß-Blockers With Functional Outcomes, Death, and Rehospitalization in Older Nursing Home Residents

24,00

Pignatelli Pasquale Sapienza Università di Roma TRS-2018-00001400 4- Safety ElderlyFactors affecting adherence to anticoagulant therapy in very elderly affected by atrial fibrillation treated with Direct Oral AntiCoagulants

24,00

Gatti DavideUnit of Rheumatology, University of Verona

TRS-2018-00001531 1 - Rare Diseases Northern Italy Network of Osteogenesis Imperfecta 24,00

Borghi Elisa Università degli Studi di Milano TRS-2018-00001744 3 - Gender MedicineAssessing microbiota changes as biomarker of antiepileptic adverse effects during pregnancy

24,00

Bandi Claudio Università degli Studi di Milano TRS-2018-00001514 5 - AMRMicrobial genomics and analysis of health big data for the control of antibiotic resistance and nosocomial infections

24,00

Vener Claudia University of Milan TRS-2018-00001573 1 - Rare DiseasesImatinib versus second and third generation tyrosine kinase inhibitors (TKIs) as first line therapy for chronic phase (CP) chronic myeloid leukemia (CML) in adults

24,00

Vacca Angelo University of Bari "Aldo Moro" TRS-2018-00001722 4- Safety ElderlyStudy REVEAL: Reduction of sarcopenia/frailty/cachexia development in the elderly with the combined administration of resveratrol and lysozyme.

24,50

Antinori AndreaIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani IRCCS

TRS-2018-00001370 4- Safety ElderlyA randomized trial on a de-intensified antiretroviral dual combination strategy in older-aged HIV individuals with non-communicable comorbidities: effect of de-prescribing on toxicity, cellular senescence, inflammation and polypharmacy.

24,50

Gasparini SaraMagna Graecia University of Catanzaro

TRS-2018-00001745 4- Safety ElderlyEfficacy and safety of antiepileptic drugs for the treatment of late-onset epilepsy: a systematic review and meta-analysis.

24,50


Di Lorenzo Giuseppe AOU Federico II of Naples TRS-2018-00001760 1 - Rare DiseasesNeoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy followed by surgery plus adjuvant radiotherapy and avelumab for locally advanced penile cancer

25,00

Moscetti LucaAzienda Ospedaliero-Universitaria Policlinico di Modena

TRS-2018-00001774 4- Safety ElderlyExtended adjuvant therapy with aromatase inhibitors in the older population with early breast cancer, exploring the optimal duration of endocrine therapy: a systematic review of literature and metanalysis.

25,00

Bonfanti PaoloAzienda Socio-Sanitaria Territoriale di Lecco

TRS-2018-00001676 3 - Gender MedicineDrug-drug interactions between antiretrovirals and hormonal contraceptives in HIV-positive women of reproductive age: durability, safety and pharmacokinetics of ARV and HC in an Italian multicenter cohort study

25,00

Bolignano DavideCNR-Institute of Clinical Physiology

TRS-2018-00001320 3 - Gender MedicineINTERVENTIONS FOR PREVENTING MULTIPLE SCLEROSIS RELAPSES IN PREGNANCY AND PUERPERIUM: A SYSTEMATIC REVIEW AND META-ANALYSIS

25,00

Volterrani Maurizio IRCCS San Raffaele Pisana TRS-2018-00001366 4- Safety Elderly Clinical utility of ivabradine in patients with chronic obstructive pulmonary disease. 25,00

Vai Silvia Istituto Auxologico Italiano IRCCS TRS-2018-00001450 1 - Rare DiseasesMuscle fibrosis and low bone mass in Duchenne Muscular Dystrophy, with special focus on the role of microRNAs.

25,50

Capuano AnnalisaUniversità degli studi della Campania "Luigi Vanvitelli"

TRS-2018-00001232 4- Safety ElderlyRisk minimization of potentially inappropriate preScripTions for ELderLy patients in CAmpania Region (STELLAR)

25,50

Rozzini Luca Università degli Studi di Brescia TRS-2018-00001728 4- Safety ElderlyA real-world survey of depression and depressive symptoms in patients affected by Mild Cognitive Impairment (MCI): gender differrence.

25,50

Veronese Nicola Consiglio Nazionale delle Ricerche TRS-2018-00001380 4- Safety ElderlyLOW DOSE ASPIRIN AND HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META-ANALYSES OF OBSERVATIONAL AND INTERVENTIONAL STUDIES

26,00

Monti Giacomo Fondazione Centro San Raffaele TRS-2018-00001341 4- Safety ElderlyUse of early non-invasive ventilation to reduce the need for intensive care unit in elderly patients. A multicenter randomized trial. E-NIV-E.

26,00

Pasina LucaIRCCS - Istituto di Ricerche Farmacologiche Mario Negri

TRS-2018-00001584 4- Safety ElderlyOptimization of psychotropic drug prescription in elderly nursing home residents and impact on cognitive functions and behavioural disorder symptoms

26,00

Gaviani Paola IRCCS Neurologico Carlo Besta TRS-2018-00001628 4- Safety ElderlyMulticenter phase III randomized trial on the efficacy and safety of Enoxaparin versus no treatment for venous thromboembolism prophylaxis in elderly patients with high grade recurrent glioma.

26,00

Cozzolino Mario Gennaro University of Milan TRS-2018-00001349 4- Safety Elderly

Evaluation of the appropriateness of use of renin-angiotensin-aldosterone system (RAAS) inhibitors in elderly patients with chronic kidney disease (stages 5-5D): adherence, clinical outcomes, healthcare resource use and direct costs in charge to Lombardy Regional Health Service (RHS).

26,00

Rizzardini GiulianoLuigi Sacco Hospital ASST Fatebenefratelli Sacco

TRS-2018-00001762 3 - Gender MedicineA retrospective and prospective observational study for evaluation of gender differences in chronic hepatitis C treatment response

26,50

Trepiccione FrancescoUniversity of Campania "Luigi Vanvitelli"

TRS-2018-00001239 1 - Rare DiseasesdaPagliflozin in fAnconi bickel syndrome: a Randomized, DOuble blind, CROSSover trial: the PARADOX study

26,50


Arisi Mariachiara ASST Spedali Civili di Brescia TRS-2018-00001411 4- Safety Elderly

Activity of oral-photochemotherapy on plasmacytoid dendritic cells and T regulatory cells in skin lesions and peripheral blood in psoriatic elderly patients.(Running title: Photochemotherapy and plasmacytoid dendritic cells and T regulatory cells in psoriasis of the elderly)

27,00

Matera Maria GabriellaCampania University Luigi Vanvitelli

TRS-2018-00001603 4- Safety ElderlyMeta-analytic evaluation of long-term efficacy and safety of monoclonal antibodies in elderly patients with uncontrolled allergic asthma.

27,00

Nodari SavinaSpedali Civili and University of Brescia

TRS-2018-00001651 3 - Gender MedicinePROGNOSTIC AND MULTIMARKER EVALUATION OF WOMEN WITH HEART FAILURE TREATED ACCORDING TO CURRENT GUIDELINES: AN OBSERVATIONAL, PROSPECTIVE, MUTICENTRE REAL WORLD STUDY. VENERE-HF STUDY.

27,00

Cindolo Luca ASL Abruzzo2 TRS-2018-00001279 4- Safety ElderlyEfficacy, safety, costs and persistence of androgen deprivation therapy in elderly men with prostate cancer: a real world study

27,50

Biolo GianniAzienda Sanitaria Universitaria Integrata di Trieste - ASUITs

TRS-2018-00001543 5 - AMRPredictive model for an early identification of drug resistant community acquired pneumonia (CAP): a prospective multicenter study. 27,50

Sasso Loredana DISSAL, Univerisity of Genoa TRS-2018-00001679 4- Safety ElderlyImproving adherence to polypharmacy treatment at home: implementation of a unitary dose model with the support of nurses.

27,50

Cascella MarcoIstituto nazionale Tumori. IRCCS, Fondazione Pascale, Napoli

TRS-2018-00001594 5 - AMRComparative efficacy and safety of antimicrobial regimens for MDR and XDR Pseudomonas aeruginosa: a systematic review and Bayesian network meta-analysis

27,75

Franchi CarlottaIRCCS-Istituto di Ricerche Farmacologiche Mario Negri

TRS-2018-00001275 4- Safety ElderlyA trained hospital pharmacist-led medication review to reduce unplanned hospital readmissions in the elderly on polypharmacy: a large scale stepped wedge cluster randomized controlled trial

28,00

Fazio Nicola Istituto Europeo di Oncologia TRS-2018-00001757 1 - Rare DiseasesPRospective Observational study on Predictive factors of response to first-line chemotherapy with cisplatin / carboplatin plus etoposide in extra-lung High grade nEuroendocrine Neoplasms (NENs).

28,00

Ingegnoli Francesca Università degli Studi di Milano TRS-2017-00001209 1 - Rare DiseasesSYSTEMIC PHARMACOLOGICAL INTERVENTIONS FOR SCLERODERMA-RELATED INTERSTITIAL LUNG DISEASE: SYSTEMATIC REVIEW, NETWORK META-ANALYSIS AND HEALTH ECONOMIC EVALUATION

28,50

Solmi Marco University of Padua TRS-2018-00001539 4- Safety ElderlySAfety and effectiveness of psychopHarmacologic treatment in the elderly population: an Umbrella review of Meta-ANalyses on randomized controlled trials and cohort studies.

29,50

Barbetta CarloAAS5 Friuli Occidentale - S.C. di Pneumologia

TRS-2018-00001669 4- Safety ElderlyNebulized furosemide and its impact on airways resistance, reactance and small airways in chronic heart failure, COPD and overlap CHF-COPD syndrome: a single center randomised, double blind, placebo controlled crossover n-of-1 trial.

30,00

Calogero PietroAzienda ospedaliero-universitaria policlinico Sant'orsola Malpighi Bologna

TRS-2018-00001696 4- Safety ElderlyImpact of an hospital initiated, community enforced program of deprescribing on an aged population. A parallel cohort, prospective study.

30,00

Sgrulletta Roberto Università Campus BioMedico TRS-2018-00001751 1 - Rare DiseasesNew biomarkers for early Fibrosis in Mucous Membrane Pemphigoid (MMP): towards personalizing approaches.

30,00


Laudisio AliceUniversità Campus Bio-Medico di Roma

TRS-2018-00001671 4- Safety ElderlyThe impact of comprehensive geriatric assessment on treatment decisions and quality of life in older patients with hematological malignancies: randomized case-control study.

30,00

Calzetta LuiginoUniversità degli Studi di Roma "Tor Vergata"

TRS-2018-00001338 4- Safety ElderlyTherapeutic use of heparin and derivatives beyond anticoagulation in comorbid elderly patients with bronchial asthma and chronic obstructive pulmonary disease: a by-dimensional pairwise and network meta-analysis on efficacy and safety

30,00

De Sarro GiovambattistaUniversity of Catanzaro - AOU Mater Domini

TRS-2018-00001623 4- Safety ElderlyAssessment of Inappropriate Drugs and/or nutraceutic compounds use, Adverse drug Reactions and Possible drug interactions in Elderly polytreated patients

30,00

Brisinda DonatellaUniversità Cattolica del Sacro Cuore

TRS-2018-00001782 4- Safety Elderly SGLT-2 inhibitors in atrial fibrillation: the new "antiarrhythmic" drugs? 30,50

Leone Francesca"Annunziata" Hospital, Dep. Nephrology, Dialysis and Transplantation

TRS-2018-00001680 5 - AMROPTImization of Citomegalovirus Anti-viral therapy strategy in REnal transplantation recipients

31,00

Zanetti OrazioIRCCS Centro San Giovanni di Dio Fatebenefratelli

TRS-2018-00001515 4- Safety ElderlyObservational study: risks and benefits of trazodone, citalopram and quetiapine in the treatment of agitation and other behavioral disturbances in Dementia patients (BPSD).

31,00

Beretta Luigi Ospedale San Raffaele TRS-2018-00001347 4- Safety Elderly

Chronic post-surgical pain (CPSP) in elderly patients. Therapy modifications according to comorbidities and concomitant administration of multiple drugs. Evaluation of the extent of the problem, its burden on patients' quality of life and of treatment effectiveness with related side-effects.

31,50

Di Francia RaffaeleGORI ONLUS gruppo oncologico Ricercatori Italiani

TRS-2018-00001492 4- Safety ElderlyPharmacogenomics as a tool to prevent drug-related toxicity in the elderly patients with chronic metabolic disease receiving multiple symptomatic treatments: a pilot study.

32,00

Manfellotto DarioOspedale San Giovanni Calibita Fatebenefratelli- Isola Tiberina

TRS-2018-00001586 3 - Gender MedicineANTIHYPERTENSIVE DRUGS IN PREGNANCY. SAFETY AND RELIABILITY OF AN OFF-LABEL THERAPY. CLINICAL AND HEMODYNAMIC EVALUATION (ADIPCHE).

32,00

Ettorre Evaristo Università La Sapienza - Roma TRS-2018-00001365 4- Safety ElderlyEffectiveness of the antidepressant S-adenosylmethionine (SAM) in delaying cognitive decline in patients affected by Alzheimer's type dementia

36,50

Documents

Principal Investigator Istituzione Codice AIFA Area ... Siciliano Gabriele; Department of Clinical and Experimental Medicine, Neurological Clinics, University of Pisa TRS-2018-00001625