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Introduction to theIntroduction to theAKC Canine Health AKC Canine Health

FoundationFoundation

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MissionMission

To raise funds to support quality researchTo raise funds to support quality research Causes of diseaseCauses of disease Earlier, more accurate diagnosesEarlier, more accurate diagnoses Better, more effective treatmentsBetter, more effective treatments

To help dogs, and their owners, live To help dogs, and their owners, live

longer, healthier liveslonger, healthier lives

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AKC Canine Health AKC Canine Health Foundation Created in Foundation Created in 19951995

American Kennel Club always American Kennel Club always sponsored researchsponsored research

AKC Delegates Health Committee AKC Delegates Health Committee recommended the creation of a recommended the creation of a specialized organizationspecialized organization

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How we fund our workHow we fund our work American Kennel ClubAmerican Kennel Club Nestle Purina PetCare Co.Nestle Purina PetCare Co. Pfizer Animal HealthPfizer Animal Health Annual FundAnnual Fund Club SupportClub Support Fundraising activities & eventsFundraising activities & events Memorial & Honorarium donationsMemorial & Honorarium donations Planned Giving Planned Giving MembershipMembership

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Since 1995...Since 1995...

We have become the largest funder of We have become the largest funder of exclusively canine health research in exclusively canine health research in the world.the world.

Over 550 studies fundedOver 550 studies fundedDiagnostic StudiesDiagnostic Studies Genetics of Disease Genetics of Disease

Molecular BiologyMolecular Biology Treatment Treatment

PhysiologyPhysiology Epidemiology Epidemiology

EducationEducation

More than $25 million allocatedMore than $25 million allocated

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In just 15 years…In just 15 years…

More than 90 Universities & More than 90 Universities & research institutions funded world research institutions funded world widewide

286 researchers funded286 researchers funded

200 clubs, individuals and other 200 clubs, individuals and other organizations sponsoring researchorganizations sponsoring research

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Top Ten Health ConcernsTop Ten Health Concerns

1: Hip Dysplasia1: Hip Dysplasia

2: Allergies 2: Allergies

3: Epilepsy3: Epilepsy

4: 4: Hemangiosarcoma Hemangiosarcoma

5: Hypothyroidism 5: Hypothyroidism

6: Lymphoma6: Lymphoma

7: Patellar Luxation7: Patellar Luxation

8: Cataracts8: Cataracts

9: GDV/Bloat9: GDV/Bloat

10: Atopic 10: Atopic DermatitisDermatitis

Information from the 2010 Information from the 2010

Poll of Parent ClubsPoll of Parent Clubs

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Animal Treatment & CareAnimal Treatment & Care No animals were harmed in the No animals were harmed in the

making of this presentationmaking of this presentation

No animals are harmed No animals are harmed in the research we support in the research we support Use of blood samples, cheek swabs for Use of blood samples, cheek swabs for

genetic studiesgenetic studies

Use of free-living (client-owned) dogs Use of free-living (client-owned) dogs for clinical studiesfor clinical studies

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Types of ProgramsTypes of Programs

ACORNs: Grants of less than $12,000; ACORNs: Grants of less than $12,000; revolving deadline.revolving deadline.

OAKs: Grants of more than $12,000; annual OAKs: Grants of more than $12,000; annual grant cycle. grant cycle.

Educational Seminars & SymposiaEducational Seminars & Symposia

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Significant Significant Discoveries to Discoveries to

Improve Canine Improve Canine HealthHealth

CHF research projects investigate the genetic associations CHF research projects investigate the genetic associations with various diseases. Some of these studies resulted with various diseases. Some of these studies resulted

directly in the development of genetic tests that help prevent directly in the development of genetic tests that help prevent the occurrence of the disease in future generations. Others the occurrence of the disease in future generations. Others increased the understanding of complex genetic diseases increased the understanding of complex genetic diseases

such as cancer which will help in the development of better such as cancer which will help in the development of better diagnostics and treatments of these diseases.diagnostics and treatments of these diseases.

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Genetic DiscoveriesGenetic Discoveries Genetic tests developed as a result of CHF grants:Genetic tests developed as a result of CHF grants:

Hereditary NephritisHereditary NephritisProgressive Retinal AtrophyProgressive Retinal AtrophyCongenital Stationary Night Congenital Stationary Night BlindnessBlindnessCanine CystinuriaCanine Cystinuriavon Willebrand's Disease von Willebrand's Disease Copper Toxicosis Copper Toxicosis Fanconi Syndrome Fanconi Syndrome Hereditary CataractsHereditary CataractsPrimary Lens Luxation Primary Lens Luxation Hereditary Ceroid Hereditary Ceroid Lipofuscinosis Lipofuscinosis

Neonatal Encephalopathy Neonatal Encephalopathy Degenerative Myelopathy Degenerative Myelopathy Mucopolysaccharidosis Type Mucopolysaccharidosis Type VI VI Coat Color and Merle geneCoat Color and Merle geneRidgelessnessRidgelessnessExercise-Induced CollapseExercise-Induced CollapseHyperparathyroidismHyperparathyroidismHereditary Cerebellar Cortical Hereditary Cerebellar Cortical DegenerationDegenerationExercise Induced CollapseExercise Induced Collapse

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Other Discoveries:Other Discoveries:

Medical Surveillance of Dogs Deployed to the Medical Surveillance of Dogs Deployed to the World Trade Center and the PentagonWorld Trade Center and the Pentagon

Cynthia Otto, DVM, PhDCynthia Otto, DVM, PhDUniversity of PennsylvaniaUniversity of Pennsylvania

Pathology and toxicology findings for search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites: initial five-year Pathology and toxicology findings for search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites: initial five-year surveillance. Fitzgerald SD, Rumbeiha WK, Emmett Braselton W, et al. surveillance. Fitzgerald SD, Rumbeiha WK, Emmett Braselton W, et al. J Vet Diagn InvestJ Vet Diagn Invest 2008;20:477-484. 2008;20:477-484.

Medical and behavioral surveillance of dogs deployed to the World Trade Center and the Pentagon from October 2001 to June 2002. Otto Medical and behavioral surveillance of dogs deployed to the World Trade Center and the Pentagon from October 2001 to June 2002. Otto CM, Downend AB, Serpell JA, et al. CM, Downend AB, Serpell JA, et al. Journal of the American Veterinary Medical AssociationJournal of the American Veterinary Medical Association 2004;225:861-867. 2004;225:861-867.

Field treatment of search dogs: lessons learned from the World Trade Center disaster. Otto CM, Franz MA, Kellogg B, et al. Field treatment of search dogs: lessons learned from the World Trade Center disaster. Otto CM, Franz MA, Kellogg B, et al. Journal of Journal of Veterinary Emergency and Critical CareVeterinary Emergency and Critical Care 2002;12:33-42. 2002;12:33-42.

Deployment morbidity among search-and-rescue dogs used after the September 11, 2001, terrorist attacks. Slensky KA, Drobatz KJ, Deployment morbidity among search-and-rescue dogs used after the September 11, 2001, terrorist attacks. Slensky KA, Drobatz KJ, Downend AB, et al. Downend AB, et al. Journal of the American Veterinary Medical AssociationJournal of the American Veterinary Medical Association 2004;225:868-873. 2004;225:868-873.

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Other Discoveries:Other Discoveries:

Sensitive and Specific Diagnostic Test for Sensitive and Specific Diagnostic Test for Leishmania infantumLeishmania infantum

Christine Petersen, DVM, PhDChristine Petersen, DVM, PhDIowa State UniversityIowa State University

Immunologic Indicators of Clinical Progression during Canine Leishmania infantum Infection. Boggiatto PM, Ramer-Tait AE, Metz K, et al. Immunologic Indicators of Clinical Progression during Canine Leishmania infantum Infection. Boggiatto PM, Ramer-Tait AE, Metz K, et al. Clin Vaccine ImmunolClin Vaccine Immunol 2010;17:267-273. 2010;17:267-273.

Canine Leishmaniasis in North America: Emerging or Newly Recognized? Christine AP, Stephen CB. Canine Leishmaniasis in North America: Emerging or Newly Recognized? Christine AP, Stephen CB. The Veterinary clinics of North America The Veterinary clinics of North America Small animal practiceSmall animal practice 2009;39:1065-1074. 2009;39:1065-1074.

Leishmaniasis, an Emerging Disease Found in Companion Animals in the United States. Petersen C. Leishmaniasis, an Emerging Disease Found in Companion Animals in the United States. Petersen C. Topics in Companion Animal MedicineTopics in Companion Animal Medicine 2009;24:182-188.2009;24:182-188.

New Means of Canine Leishmaniasis Transmission in North America: The Possibility of Transmission to Humans Still Unknown. Petersen C. New Means of Canine Leishmaniasis Transmission in North America: The Possibility of Transmission to Humans Still Unknown. Petersen C. Interdisciplinary Perspectives on Infectious DiseasesInterdisciplinary Perspectives on Infectious Diseases 2009. 2009.

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Tying It All TogetherTying It All Together

The Canine Genome The Canine Genome Sequence, completed Sequence, completed in 2005, provided in 2005, provided investigators with a investigators with a tool to allow for more tool to allow for more efficient, accurate and cost efficient, accurate and cost effective research.effective research.

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Human vs. Canine Human vs. Canine GenomesGenomes

HumanHuman 13 years13 years $2.7 billion$2.7 billion

CanineCanine 7 months7 months $50 million$50 million

The two genomes The two genomes are about 85% the are about 85% the samesame

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Each New Piece of Each New Piece of Knowledge Brings...Knowledge Brings...

Genetic tests – breeders can Genetic tests – breeders can eliminate diseaseseliminate diseases

Earlier diagnoses andEarlier diagnoses and

better, more effective better, more effective

treatmentstreatments Ultimately, curesUltimately, cures

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How Do We Do This?How Do We Do This?

High quality researchHigh quality research

Educational programsEducational programs

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Canine Health Canine Health ResourcesResources

Interactive Website Interactive Website www.AKCCHF.orgwww.AKCCHF.org

PodcastsPodcasts

Canine Health Information Center Canine Health Information Center (CHIC)(CHIC)

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Canine Health Canine Health Information Center Information Center (CHIC)(CHIC) Mission: To provide a source of Mission: To provide a source of

health information for owners, health information for owners, breeders and scientists, which will breeders and scientists, which will assist in breeding healthy dogsassist in breeding healthy dogs

Joint program between the AKC Joint program between the AKC Canine Health Foundation and the Canine Health Foundation and the Orthopedic Foundation for AnimalsOrthopedic Foundation for Animals

www.caninehealthinfo.orgwww.caninehealthinfo.org

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CHICCHIC

Open database for health test resultsOpen database for health test results Required tests determined by Parent Required tests determined by Parent

Club, not CHF or OFAClub, not CHF or OFA Database is about encouraging health Database is about encouraging health

testing, not about “normalcytesting, not about “normalcy

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CHIC DNA Repository CHIC DNA Repository

Accepts both blood samples and cheek Accepts both blood samples and cheek swabsswabs

Provides researchers with optimized family Provides researchers with optimized family groupsgroups

Allows breeders to take advantage of future Allows breeders to take advantage of future DNA-based tests as they become available.DNA-based tests as they become available.

Foster a team environment between Foster a team environment between breeders andbreeders and

the research community improving the research community improving the the

likelihood of genetic discoverylikelihood of genetic discovery

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Canine Health Canine Health EducationEducation

Breeders/Owners Symposia Breeders/Owners Symposia

Presentations made by the President’s Presentations made by the President’s Council, CHF Board and StaffCouncil, CHF Board and Staff

Assistance with finding presenters for Assistance with finding presenters for club meetingsclub meetings

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Purina Parent Purina Parent Club Club Partnership Partnership ProgramProgram Purina and parent clubs work Purina and parent clubs work together to help promote canine together to help promote canine health and well-being.health and well-being.

Purina’s goal is to provide financial Purina’s goal is to provide financial support to national parent clubs and support to national parent clubs and the AKC Canine Health Foundation the AKC Canine Health Foundation to help dogs live longer, healthier to help dogs live longer, healthier lives.lives.

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How Purina How Purina works works with clubswith clubs

National Parent Breed Clubs earn money National Parent Breed Clubs earn money through member participation in Purina through member participation in Purina Pro Club.Pro Club.

You qualify to join Pro Club if you breed a You qualify to join Pro Club if you breed a litter a year or care for more than 5 dogs: litter a year or care for more than 5 dogs: 1-877-PRO-CLUB.1-877-PRO-CLUB.

Breed clubs can earn 10 percent of the Breed clubs can earn 10 percent of the value of all points from valid Purina value of all points from valid Purina weight circles on dog food bags. weight circles on dog food bags.

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Purina Purina ParticipationParticipation 164 clubs signed up to participate in 2009164 clubs signed up to participate in 2009 Breed clubs raised nearly $300,000 in 2009, Breed clubs raised nearly $300,000 in 2009,

half of which came to the AKC Canine Health half of which came to the AKC Canine Health Foundation. The other half may be allocated Foundation. The other half may be allocated to the club’s education, research or rescue to the club’s education, research or rescue efforts.efforts.

Since the program began in 2002, more than Since the program began in 2002, more than $3 million has been raised for canine health $3 million has been raised for canine health research, with half the earnings going research, with half the earnings going directly to the AKC Canine Health Foundationdirectly to the AKC Canine Health Foundation

See See www.purinaproclub.comwww.purinaproclub.com

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The Purina Challenge:The Purina Challenge:How to increase CHF How to increase CHF fundsfunds Parent Clubs must sign up for the Parent Clubs must sign up for the

program.program.

Club members must feed Purina, Club members must feed Purina, participate in Pro Club and declare their participate in Pro Club and declare their breed.breed.

Parent Clubs must promote the program Parent Clubs must promote the program (advertising, newsletters & club events).(advertising, newsletters & club events).

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Let us help Let us help you…you…

Ask for literature,Ask for literature, Ask for speakers;Ask for speakers; Ask for publicityAsk for publicity

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MembershipMembership

Join Now and Become a Member!Join Now and Become a Member! Membership is $30 for an individual, $50 for a Membership is $30 for an individual, $50 for a

family at the same address or $5 for a junior family at the same address or $5 for a junior under the age of eighteen. under the age of eighteen.

The benefits of membership are:The benefits of membership are: Wear our AKC Canine Health Foundation lapel pinWear our AKC Canine Health Foundation lapel pin Receive our informative quarterly newsletterReceive our informative quarterly newsletter Help dogs of all kinds live longer, healthier lives.Help dogs of all kinds live longer, healthier lives.

Join by visiting our website Join by visiting our website www.AKCCHF.orgwww.AKCCHF.org

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Toll-Free: 888.682.9696Toll-Free: 888.682.9696

(919-334-4010 outside the US)(919-334-4010 outside the US) Website: Website: www.AKCCHF.orgwww.AKCCHF.org Email: Email: chf@AKCCHF.orgchf@AKCCHF.org Mailing address:Mailing address:

PO Box 900061PO Box 900061

Raleigh, NC 27675-9061Raleigh, NC 27675-9061

Contact InformationContact Information