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Presented by:Dr. Afsana Jahan (PGT)
Dr. Aditi Baruah (MD); Dr. P. Bishwanath (MD)Department of Paediatrics
Assam Medical College & Hospital, Dibrugarh
Thalassemia is the commonest chronic haematological
disease needing repeated blood transfusion.
North-East specially Assam is a reservoir of abnormal
haemoglobins & also thalassemia because of ethnic
diversity of the inhabitants.
Present thalassemia clinic was established in April’2005,
AMCH, Dibrugarh where regular follow-up of thalassemia
pateints are done.
To study the follow-up cases of haemo-
globinopathy with special reference to
thalassemia in thalassemia clinic
Place of Study : Thalassemia clinic, AMCH
Period of Study : May’2005 to Oct’2007
Study universe : 50 diagnosed and registered
cases of Haemoglobinopathy
Selection criteria : Cases of Haemoglobinopathy
diagnosed by HPLC.
SPLEEN SIZEβ THALASSEMIA
MAJORHbE – β
THALASSEMIA
Not palpable 1 3
< 2cm 0 2
2 – 7cm 1 11
>7cm 5 2
Splenectomized 4 6
No. of patients
Drug and dose
mg/kg/day
Length of study
S. Ferritin level (μg/L)
Initial Final
16Deferiprone
50 – 1001yr 3261 1420
4Desferoxami
ne35 – 55
1yr 3190 1392
3 Combined9month
s5261 1276
Family study and convincing parents and relatives for necessity of the test.
Irregular follow-up visits. Irregular blood transfusion Lack of voluntary blood donation. Cost of filters and chelation therapy limits
their use. Cost of different laboratory tests.
Public awareness. Education of health professional. Antenatal diagnosis. Emphasis on conventional treatment in particular
chelation in view of its high efficacy. Cure of the disease with increasing possibility of
bone marrow transplantation and gene therapy. Concrete support for achieving high standard for
management of thalassemia in this part of Country.
Thalassemia clinic is playing an important role in making thalassemia a preventable, manageable and curable disease in prospect of high incidence in this region.