Umberto

Veronesi

presentado por

Roberto Orecchia

Director Scientifico

IEO in Milan & CNAO in Pavia

5th November 2017

On November 8th,

we lost

a visionary and true

gentleman

During his long and

productive life,

he made significant

contribution

to surgical science,

to cancer care and

prevention, and

to medical education

From

Maximum tolerable

treatment

New Paradigm

To

Minimum effective

treatment

The Breast

model

ABVD

CMF

In Milan

the hystory

of breast

cancer

changed

….. In the italian study, begun in 1973 by Dr Umberto Veronesi …..

Months

Pro

bab

ility

0 60 120 180 240 300

0.0

0.2

0.4

0.6

0.8

1.0

Halsted (349)

Quadrantectomy + RT (352)

1981; Milan I trial - Survival

https://www.google.ch/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&ved=0ahUKEwic_JbArqfXAhWJOCYKHX7QAXMQjRwIBw&url=https%3A%2F%2Fellanzallamas.com%2Ftag%2Fcancer-de-mama%2F&psig=AOvVaw2NmDDFkwt5_rT3dlg3JFon&ust=1509968761336549

Milan

Trial

0

1990

x 1

000

50

100

150

200

250

1980 2000 1990

NSABP

Trial

300

350

2010

Radical Mastectomy

Breast Conserving Surgery

• Radiotherapy after breast-conserving surgery in women with localized cancer of the breast (N Engl J Med, 1993)

• Avoiding axillary dissection in breast cancer surgery: a randomized trial to assess the role of axillary radiotherapy (Ann Oncol, 2005)

• Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomized controlled equivalence trial (Lancet Oncol, 2013)

CNAO – Pavia – May 2001

III

II

I

Sentinel Node Biopsy in Breast Cancer

European Institute of Oncology (1996 - 2017)

Radiotherapy after breast-conserving surgery in women with localized cancer of the breast

(N Engl J Med, 2003)

Follow-up (years)

Pro

po

rtio

n o

f p

ati

en

ts s

urv

ivin

g (

%)

Sentinel-lymph-node biopsy as a staging procedure in breast cancer: update of a randomised

controlled study (Lancet Oncol, 2006)

• Science for the Peace

• Future of Science Conventions

• European School of Oncology

• EUSOMA

• EURAMA

• AIRC

• European Institute of Oncology

• Umberto Veronesi Foundation

• Europa Donna

• International Society of Cancer Chemoprevention

• Committee of Cancer Expert of the European Union

• International Union Against Cancer

• Federation of the European Cancer Societies

• EORTC

• International Group for Melanoma

And in 2014 he passed the torch

Many Thanks, Umberto !