Prep & Industrial Scale - ChemsupplyThe system NS 4101 comprises of a chromatography pump (Flow rate 10 ml/min) combined with a uv to visible detector for isocratic runs for analysis

Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland

Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74

[email protected] , www.chromatographyshop.com

1 Vers. 01122012

Prep & Industrial Scale

Chromatography

systems


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


2 Vers. 01122012

Prep- to Industrial Process

Chromatography is about producing

compounds at the highest yield,

lowest costs and required purity!

“Consensus™” stands for achieving

this objective!

Chromatography is considered by many people an exotic purification / separation

technology. They would use chromatography only if re-crystallization or distillation is

unsuitable. We are growing into an era where active ingredients or excipients are

produced for smaller markets or don’t crystallise. Many new molecules are highly active

and produced in small quantities. New ways in chromatography will revolutionize the

pharmaceutical, biotech and fine chemical industry!

We are a group of independent and innovative chromatography pioneers that have built

through the years our own enterprises that specialise in developing and manufacturing

unique particles, mechanical and software tools including processes. Pooling all our

skills and knowledge we move chromatography into new era - we convert

chromatography into the most competitive of all purification methods. With our

accumulated skill power we help you to manufacture the most competitive

compounds!

We offer

1. Very competitive Turn-Key Chromatography Plants

2. Advanced Process-Know-How

3. Novel Process Components to advance your current plant (Pumps, Detectors,

new or very competitive phases with unique properties etc.)

Check us out - we will surprise you!

Please send us answers to the questions in the attachment.


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


3 Vers. 01122012

NS4101 Unitary high pressure analytical HPLC system

Art. Nr. AS1001

The system NS 4101 comprises of a chromatography pump (Flow rate 10 ml/min)

combined with a uv to visible detector for isocratic runs for analysis and semi prep –

operations. It is a very stable system for routine analysis in a production lab. Sample

injection is via manual injection valve.

Column at your own choice


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


4 Vers. 01122012

NS4201 Binary high pressure analytic HPLC system

Art. Nr. AS20001

The System NS4201 is very competitive analytical binary system comprising of two

HPLC piston pumps and a UV – visible detector, a manual injection valve and static

mixer. For gradient and isocratic operation in a routine analytical lab operation.


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


5 Vers. 01122012

NS 4205 Binary high pressure semi-preparative HPLC system

Art. Nr. AS 20005

The system NS 4205 is a binary semi-prep HPLC System with a constant flow 50 ml/

min flow rate. Sample injection is through a manual injection valve and a semi-prep static

mixer. The UV – visible detector has a semi prep –flow cell. It is ideal for gradient and

isocratic mode HPLC. It is ideal for process research and peptide purification


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


6 Vers. 01122012

The System LS 2010 is a preparative binary liquid phase purification-separation HPLC

plant with flow rate of 100 ml/ min. For 10 to 50 mm id pre-packed column. The system

is supplied with a 50 mm id Dynamic axial compressed column. The detector is a prep-

UV-visible detector.


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


7 Vers. 01122012

The System PS 30030 is a ternary preparative separation purification system with flow

rates up to 300 ml/ min. The system utilizes either manual injection or injection through

ternary HPLC pump. The peaks are collected via a UV- visable detector . With the system

comes with a 80 mm id DAC column


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


8 Vers. 01122012

Ternary preparative liquid phase large scale separation and

purification system

Art. Nr. PS30060.10

Performance Characteristics

Ternary preparative high pressure purification and separation system with excellent

price/performance ratio. Max. Flow rate is 600 ml/min. Injection is via ternary HPLC pump.

Large 20 ml injection loop. 100 mm id DAC Column.


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


9 Vers. 01122012

Ternary preparative large scale liquid phase separation and purification

system

Art. Nr. PS 30100.15

Performance characteristics

Two large prep HPLC pumps (Flow rate: max. 1000 ml/ min) for isocratic and gradient

mode of operation. One prep sample injection pump, static mixer and UV – visible detector.

DAC column 150 mm id.


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


10 Vers. 01122012

Ternary commercial scale preparative separation and purification

system

Art. Nr. CS 30300.20

Performance characteristic

Ternary industrial scale purification & separation system comprising of two large prep HPLC

pumps (Flow rate: max. 3000 ml/ min) for isocratic and gradient mode of operation. One prep

sample injection pump, static mixer and UV – visible detector. DAC column 200 mm id.


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


11 Vers. 01122012

Commercial scale prep preparative liquid phase chromatographic

separation and purification system

Large production scale system comprising of HPLC pumps for solvent infusion, slurry

mixing, sample injection. The process includes also DAC column ranging from 150 mm to

2000 mm id, a detection system, process- and data control and fraction collection. For

large flow rates e.g. 10, 20, 40, 80 and 120 l / min) special diaphragm pumps are being

used


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


12 Vers. 01122012

Surface Quality of DAC column

Column Material: SUS316L,

Inner walls: electropolished

Surface quality:

For ID 50mm to 200mm DAC column: less than or equal to 0.1 micrometer

For > 200 mm ID DAC column: less than or equal to 0.2 micrometer

We offer special surfaces e.g. for bio-application or servere chemical

environments.


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


13 Vers. 01122012

List of Datasheets for various components

Code

Category Product

EA Prep HPLC Systems EA001 NewStyle Unitary High Pressure Analytical Chromatography System 4101

EA010 NewStyle Binary High Pressure Analytical Chromatography System 4201

EA020 NewStyle Binary High Pressure Semi-Prep Chromatography System 4205

EA030 NewStyle Binary Separation & Purification System 2010 for Process Research

EA040 Newstyle Ternary Large Scale Preparative Separation and Purification System with 80 mm ID Column




EA080 Industrial Scale Purification & Separation System with column id ranging from 150 mm up to 2000 mm

EB Flash and Medium Pressure Pumps

EB001 LCC Consensus Pump E100SS

EB010 LCC-Consensus Low Pressure Pump LP100

EC High Pressure Liquid Chromatography Pumps

EC001 LCC Consensus HPLC Pump R 200



EC030 Newstyle Analytical HPLC Pump NP7001 EC040 Newstyle Semi Prep HPLC Pump NP 7005C

EC050 Newstyle Semi Prep HPLC Pump NP 7010C EC060 Newstyle Prep HPLC Pump NP 7030C EC070 Newstyle Prep HPLC Pump NP 7060C

EC080 Newstyle Prep HPLC Pump NP 7100C EC090 Newstyle Prep HPLC Pump NP 7300C

ED Special Pumps ED001 Parallel Prep-Chromatography Pump with Ten Heads

ED002 LCC Consensus Valveless Metering Piston Pump MP 200

EE Detectors EE001 Fixed Wavelength Detector Flash 06S

EE010 UV-VIS Diode Array Detector FLAS 10 DAD 400

EE020 UV-VIS Diode Array Detector FLAS 10 DAD 800

EE030 UV Diode Array Detector DAD 600

EE040 UV Diode Array Detector DAD 600 with external Cell

EE050 Flow Cells.


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


14 Vers. 01122012

EF Fraction Collectors EF001 LCC Consensus Rotary Fraction Collector FC 80 EF002 LCC Consensus Fraction Collector XY-FC160 EF003 LCC Consensus XY-Fraction Collector FC 1000 EF010 LCC Spider Fraction Collector EF020 Consensus Modular Fraction Collection System CMFS 4000

EF021 Racks for 4000 Series

EG Sundry Equipment EG001 Multi Column Switch Units

EH Steel Columns EH001 Custom Packable Stainless Steel HPLC columns EH020 Custom Packable Prep Stainless Steel HPLC columns

EH040 Static Axially Compressed Stainless Steel & Glass Columns EH060 Dynamic Axially Compressed Stainless Steel Columns

EI Glass Columns EI001 Medium Pressure Liquid Chromatography Glass Columns. EI020 MPLC Column Components

EI040 Low Pressure Borosilicate Glass Columns EI050 Static Axially Compresses Glass Columns

EJ Plastic Cartridges EJ001 Consensus PE Flash Chromatography Cartridges

EJ030 Empty Flash Cartridges & Components

EK Glass Cartridges EK001 Glass cartridge complete, biocompatible, up to 35 bar

EL Manual Valves EL001 LCC Consensus Prep injection Valve B & D

EM Motor Driven Valves

EM001 LCC Consensus Low Pressure 3 Port Motor Valve

EM010 LCC Consensus Low Pressure 4 Port Motor Valve

EM020 LCC Consensus Low Pressure 6 Port Motor Valve EM030 LCC Consensus Low Pressure 6 Port Motor Valve 2

EM040 LCC Consensus Low Pressure 12 and 24 Port Motor Valve

EM100 LCC Consensus High Pressure 6 Port - 2 Position Motor Valve

EM110 LCC Consensus High Pressure 10 Port - 2 Position Motor Valve

EN Software

EO Sample Drying – Solvent Recycling

EP Professional Guidelines


Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74


15 Vers. 01122012

Attachment 1

Fundamental Question in Prep Chromatography a. In which group belong your target compounds

1. Organic Synthetic Compounds with MW<2000 (Heterocycles, Vitamins, Organometallics, Hormones,

Pesticides)

2. Natural Products with MW <2000 (Saccarides, Lipides, Phospholipides, Isoprenoids, Steroids, Alkaloids,

Flavenoids, Terpenes, Polyphenols, Saponins, Proanthocyanidins, Tannins etc from a wide range of

matrixes)

3. Amino Acids, Peptides, Oligonucleotides

4. Large scale racemate purification

5. Inorganics Separation (Cations and Anions, Metals, Nobel Metals, Acids, Alkalis, Industrial

Waste,Hydrometallurgical- refining, leachages, extracts, precipitants)

6. Protein, Biomarkers and Biotherapeutic Proteins (Enzymes, Membrane Proteins, Recombinant Proteins,

Antibodies, extracts from mammalian Tissue, Erythrocytes, Yeast, Bacteria)

b. Sample preparation

1. In what condition is the compound supplied for chromatography processing?

2. Is sample preparation necessary?

3. What type of sample preparation?

c. Environmental factors

1. Does the compound have to be process in organic solvent or can it be done in aqueous systems?

2. Is ATEX configuration necessary?

3. Are there facilities for solvent recycling?

4. What shall happen with the by-products?

d. Process equipment selection

1. Anticipated Business volume (g, kg or tons per day/week or month of pure compound)?

2. Level of purity to be achieved?

3. Envisaged process life?

4. Envisaged process and maintenance costs

5. Envisaged capital cost?

6. Strategy to finance capital investment?

7. Separation materials to be used?

8. Has a phase evaluation been conducted to assure selection of the most effective material.

e. Preferred Process Mode

1. Single columns batch chromatography (Flash, MPLC, HPLC, Expanded Bed Purification, new experimental

processes)?

2. Parallel column chromatography?

3. Continuous column processes (SMB , SSR)?

4. New experimental processes?

Documents

Prep & Industrial Scale - ChemsupplyThe system NS 4101 comprises of a chromatography pump (Flow rate 10 ml/min) combined with a uv to visible detector for isocratic runs for analysis