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bioMérieux S.A.69280 Marcy l’EtoileFranceTel. : 33 (0)4 78 87 20 00Fax : 33 (0)4 78 87 20 90

www.biomerieux.comwww.biomerieux-diagnostics.com

Your partner forculture media

4 2 Committed to Meeting Your Challenges

15 2 Product Insight - Range and Culture Media

44 2 Automated Specimen Inoculation - PreviTM Isola

46 2 Specimen Protocols Guidelines “From Specimen to Plate”

Contents

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Committed to MeetingYour Challenges

4 2 Committed to Meeting Your Challenges

5 2 Expertise & Innovation

6 2 International Vision - Local Proximity

8 2 Our Quality Assurance Commitment - Making Your Daily Life Easier

10 2 Complete Product Traceability - Making Your Daily Life Easier

12 2 Environmental Protection

13 2 Shelf-life and Temperature Storage

14 2 Customer Service

Committed to MeetingYour Challenges

Laboratories are more than ever a pivotal role in ensuringpatients receive the most appropriate healthcare rapidly given the current worldwide context.

• Hospitals are faced with healthcare-associated infections that arerecognized worldwide as a major public health issue. They needeffective microbiology solutions to help with the prevention,intervention and surveillance in the fight against Healthcare-Associated Infections (HAI).

• Management of healthcare expenditure implies having the meansto ensure improved patient triage, better discerned use of antibiotics,freeing up patient beds quicker etc…

• Regulatory requirements are ever present and form an integralpart of patient safety.

• Time to result is increasingly important for many diseases; thismeans having a linear workflow right from sample managementand colony isolation to result print out.

As a key part of this healthcare picture, you as a laboratory need to have confidence in the microbiology solutions you chose toaddress these daily challenges. This is why we are committed to offering you an extensive range of cost-effective, nutrient pre-platedmedia. They are technically sophisticated to help ensure you obtaineasy-to-read, rapid results, whatever the quantity and type of micro-organism in the specimen.

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With over 45 years experience in the field of microbiology,bioMérieux has unique know-how and expertise in microbial culture,enumeration, detection, identification and antimicrobial resistancetesting.

Rapidity of diagnosis and accuracy of treatment impact clinicaloutcome. This is why bioMérieux proposes an extensive range ofquality media to ensure you have reliable, cost-effectivemicrobiological solutions to empower clinical decisions.

With your specific daily challenges in mind, we used our recognizedexpertise to create an innovative range of chromogenic media,chromID™, to provide you with the simultaneous culture andidentification of microorganisms you need. Part of this exclusiverange covers the screening of Multi-Drug Resistant Organisms tohelp in the fight against HAI.

To help optimize your daily workflow, we now offer an automatedplate inoculation system, PREVI™ Isola. This instrument standardizesplate inoculation and results while maximizing bacteria colonyisolation.

bioMérieux is still committed to offering timely, relevantsolutions now and in the future. Today, with bioMérieux, obtaining quality media solutionsis simpler than ever before.

bioMérieuxExpertise & Innovation

USAPORTLAND

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Our International vision ensures we can anticipate your mediarequirements while providing specific local solutions whereneeded. We offer worldwide media coverage with just the rightamount of proximity through our strategically placed production sites.We are closer to our customers than ever before to ensure we meetyour daily needs. There are 3 European production sites (France,the UK and Spain) - the French site being the largest site in Europe- and 5 other sites spread around the world in Australia, Brazil, theU.S.A, and Canada.

bioMérieux has manufactured culture media since 1963 and ourmain, referential site in France offers its vast industrial expertise andknow-how to the other production sites. This ensures we havestandardized, innovative products worldwide while being able toaddress more local and specific needs. This is the perfect balanceto ensure you have just which media you need exactly when youneed them.

International VisionLocal Proximity

USALOMBARD

CANADATORONTO

SPAINMADRID

FRANCECRAPONNE

AUSTRALIABRISBANE

UKBASINGSTOKE

BRAZILRIO DE JANEIRO

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To be able to do this, bioMérieux employs a rigourous Quality Assurancepolicy for all its products and services. Our Quality System is certifiedISO 9001 version 2000 for all its activities and NF EN ISO 13485version 2004 for clinical activities, including culture media.

By applying a Quality Assurance system, we ensure the reproducibilityof product performance throughout a product’s life cycle. The mainregulatory guarantee for our products is that they comply with theDirective 98/79/CE (1998/10/27) relative to medical devices for in vitro diagnostic use. As such our products must reach strict levelsof security and safety to be able to be commercialized.

Our objectives are to:

• guarantee you have the highest, reproducible quality products which comply with the strictest standards

• ensure we actively help you to meet your daily quality requirements.

Our Quality Assurance Commitment

Making Your Daily Life Easier

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To facilitate your regulatory requirements, we also provide a complete range of documents on-line in our Technical Library:

www.biomerieux.com

• Package Inserts

• Non-hazardous Product Statement

• Declaration of Product Conformity Statement

• Thermal Shock Statement

• Quality Control Certificates

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Complete Product TraceabilityMaking Your Daily Life Easier

As we are committed to providing our clients with highquality products which increase user and patient safetywhile ensuring complete product traceability, we alsofollow a number of other standards which are related tothis main directive (see page 11).

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WHAT DOES B IOMÉRIEUX PROVIDE THE USER AS PROOF

OF PRODUCT QUALIT Y ?

PA C K A G E I N S E R T S

Q U A L I T Y C O N T R O L C E R T I F I C AT E S

K I T L A B E L I N G , T H E R M A L S H O C K S TAT E M E N T ,

PA C K A G E I N S E R T S

PA C K A G I N G

WHAT DOES IT COVER ?

Clear Performance Details are given in the packageinsert of each medium. This data comes from bioMérieux's internal studies and external performance evaluation studies (performed withroutine specimens).

The Quality Control Certificate is available foreach Lot: bioMérieux provides performance criteria andthe collection strains used for Quality Control of culturemedia in the certificate.

The Shelf-Life is determined from Stability Studies: bioMérieux indicates the expiration date on each kit labelwhile storage conditions before first, and after first openingare indicated in the package insert.Temperature storage is also indicated on kit labeling(see page 13).

Clear and Detailed Labeling Information: given oneach product's label and package insert.

Guarantee of Compliance with the EC Regulations:bioMérieux gives this information on each product's labeland package insert.

Clear and Easy Symbols for all Users: given on eachproduct's label and package insert.Symbols reduce the need for multiple translation in local languages, simplify labeling, prevent the creation of differentsymbols conveying the same information.

Environmental Protection: bioMérieux confirms its environmental commitment with: recycled and recyclablecardboard, reduce waste volume and weight (see page 12).

STANDARD FOLLOWED

NF EN 13612 "Performance evaluation of in vitro diagnostic medical devices" (September 2002)This standard concerns requirements relating to the, management, assessment and documentation of manufacturer performance evaluations.

NF EN 12322 "Culture media for microbiology / Performance criteria forculture media" (July 1999)This standard concerns performance of culture media used in microbiology labs (traceability, compatibility, reproducibility of product performance throughout the product’s life cycle and suitability.

NF EN 13640 "Stability testing of in vitro diagnostic reagents" (August 2002)This standard concerns requirements for the stability of in vitro diagnostic reagents:gives specific requirement for real-time testing when generating stability data (e.g. transport determination of stability after opening.

NF EN 375 "Information provided by the manufacturer with in vitrodiagnostic reagents for professional use" (April 2001)This standard concerns information supplied by the manufacturer of in vitro diagnostic reagents including reagents, calibrators, control material and kits. It defines the information which must be indicated on labels and instructions for useof each IVD product.

NF EN 1041 "Information supplied by the manufacturer with medical devices" (October 2008)This standard concerns the information to be provided by the manufacturer for different types of medical devices covered by the EU Directives.

NF EN 980 "Graphical symbols for use in the labelling of medical devices"(July 2008)This standard concerns the graphical symbols to be used on information provided bythe manufacturer for medical devices.

ISO 15223 "Symbols to be used with medical device labels, labeling, andinformation to be supplied + amendments" (April 2000)This standard concerns symbols conventionally used to convey information essentialfor the correct and effective use, safe and effective use of medical devices.

Directive 94/62/CE "Packaging and packaging waste" (December 1994)This standard concerns the harmonization of the various national measures relativeto packaging and packaging waste to avoid/reduce the effect on the environment.This is to offer maximum environmental protection and ensure the free circulation betweenmember countries of goods following this standard.

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Environmental Protection

As part of our environmental actions for our media products, we stilluse recycled and recyclable cardboard to make our boxes but wehave worked even further on reducing the volume of plated mediapackaging. By moving from our already innovative “fold-box”principleto an ingenious, new, patented fold-lockTM principle (once flattenedthe box stays flat) we further facilitate the disposal of pre-platedculture media boxes and reduce your daily waste volume andweight. Not only do we actively try to contribute to saving ourenvironment but we help you to do the same.

In addition to following the European directive 94/62/EC “Packagingand packaging waste, one of bioMérieux’s guiding Principles is"We belong to a community". It is only natural that we embrace aresponsible attitude toward our environment in all aspects of ourbusiness worldwide as regards energy, water, paper, waste, emissions.

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15°C

25°C

Shelf-life and Temperature Storage

The shelf-life of bioMerieux's culture mediais determined by stability study results.These studies are performed in real-time.

During this stability study two kinds of thermalshocks are simultaneously applied on themedia :

• Simulation of a break in the cold chain :Thermal shocks are test temperature cyclesto which products may be subjected duringproduction or transportation.

• 4 weeks at 15-25°C.

The stability study consists of checkingthe conformity of appearance, pH, andbacteriological activity.This information is included in the ThermalShock Statement which provides you withproof of our validation process.

In addition to following the regulation of “Stability testing of in vitro diagnostic reagents” we also validate the “use” of 4-week storage at 15-25°C.This is to ensure we offer maximum flexibility in the daily work routine of laboratory technicians.

Temperature Storage Validation

Time

Temperature

Storage temperature

Thermal shocks including 4 weeks at 15-25°C

Control conform Control not conform Shelf-life

2 Example of a thermal shock protocol for preplated media: Storage: 2-8°C

10-15°C for 4 weeks18-25°C for 6 days, including 35-39°C for 8 hours15-25°C for 4 weeks2-8°C

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Customer Service

Our customers deserve only the very best andas such bioMérieux is committed to continuously

improving the quality of products and serviceswe deliver you.

Our Customer Service meets this challenge by offeringa wide range of services: rapid responses to customers'questions and complaints, tailor-made customer

product training courses, proactive and curative system maintenance and even workflow auditing.

To ensure you receive first class service regardless of yourgeographical location, local bioMérieux technical assistants

specialized in microbiology are ready to help you backed up bythe expertise of the global customer service support team. This organization provides a winning combination of local proximitywith worldwide, up-to-date knowledge to ensure our customershave the expertise and follow-up they require when needed.

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Product Insight

17 2 Chromogenic Media for

Simultaneous Isolation and Immediate Identification

23 2 Chromogenic Media for

the Screening of Multidrug Resistant Organisms

25 2 Blood Agar: Complex, Selective and Differential Media

29 2 Specific Media: Selective Isolation for Specific Organisms

38 2 Simple Media: Isolation of Organisms

41 2 Media for Susceptibility Testing

42 2 Media for Environmental Controls: Surfaces, Air, Water

For more details see technical sheets

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With chromIDTM bioMérieux offers you an extensive range of chromogenic media for the simultaneous culture and identificationof microorganisms.

Designed to meet your increasing daily challenges, these high qualitymedia provide you with reliable results and true peace-of-mind.

Our recognised expertise in culture, identification and susceptiblitytesting naturally led us to pioneer the chromogenic media conceptback in 1989. Since then, we have continued to create innovativechromogenic solutions to meet your everyday needs.

An extensive range of chromogenic media

for the simultaneous culture and identification

of microorganisms

chromIDTM CPS®/ Columbia CNA+ 5% sheep bloodChromogenic medium for the enumeration of organisms in urine specimens and the directidentification of Escherichia coli, Enterococcus, KESC and Proteeae. Selective isolation of fastidious bacteria. Determination of hemolysis.

chromID CPSColumbia CNA

+ 5% sheepblood

Incubation: 24 hoursS. epidermis ATCC 14990

chromID CPSIncubation: 24 hours

E.coli ATCC 25922,Proteus mirabilis

ATCC 43071and

Enterococci ATCC 29212

K. pneumoniae (brownish-green colonies)and Enterococci (turquoise colonies)

C. albicans

S. agalactiæ ATCC 12386 (x 2.5)

chromIDTM CPS®

2 for the isolation, enumeration and direct identification of E. coli, Proteusand Enterococci and KESC in one single step using urine specimens

Isolation and enumeration of all urinary tract pathogens.Colonies are well isolated and easy to identify with real differentiating colours.Microbial enumeration with colourless background to optimise colony counting.

Direct identification: chromID CPS contains specific substrates of the enzymatic activities to be detected.

Greater Ease-of-use:• E. coli: ß-glucuronidase (ß-GUR). No indole test required.• Proteus: spontaneous colouration of colonies producing deaminase. • Enterococci: ß-glucosidase (ß-GLU).

Greater Reliability: • Nutrient capacity.• Sensitivity of detection and specificity of colouration for the main

organisms usually found in urine.• Identification of the bacterial group KESC (Klebsiella, Enterobacter,

Serratia and Citrobacter).KESC => better colour intensity, due to increased ß-glucosidase activity.

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chromID CPS

Ref. 43 541 • kit of 20 platesRef. 43 549 • kit of 100 plates

chromID CPS/ ColumbiaCNA + 5% sheep blood

Ref. 43 463 • kit of 10 platesRef. 43 473 • kit of 20 plates*

2 C H R O M O G E N I C M E D I A F O R S I M U LTA N E O U S I S O L AT I O N A N D I M M E D I AT E I D E N T I F I C AT I O N

* Consult your local bioMérieux representative for more product information and availability.

chromIDTM Salmonella2 for the selective isolation of all Salmonella serotypes

Three chromogenic substrates optimize the selective isolation and differentiation of Salmonella:• Specific detection of the esterase enzymatic activity on a colourless background =

Pale-pink to mauve colonies for Salmonella (reading between 18 to 24 hrs)• Differentiation of other bacteria (colonies of a different colour)• Inhibition of Gram-positive bacteria and yeasts

The nutrient capacity, colour intensity, sensitivity of detection and specificity of colouration, ensure optimum differentiation of mixed cultures.chromID Salmonella enables the detection of serotype Typhi, Paratyphi and most Salmonella Lactose +

chromID Candida


Rappaport broth

Ref. 42 091 • kit of 20 tubes

Selenite F broth


chromID Salmonella


chromIDTM Candida2 for the selective isolation of yeasts and the direct identification of Candida albicans

Candida albicans colonies are coloured blue by the specific hydrolysis of a hexosaminidasechromogenic substrate (bioMérieux patent).The hydrolysis of a second substrate (pink colouration) differentiates mixed cultures and orientsidentification of other species colonies (bioMérieux patent).

Immediate identification of C. albicans in just 24 hours* = Blue coloniesGreater intensity for C. albicans colonies.

• Optimum differentiation of mixed cultures• Orientation of identification towards Candida (C. tropicalis, C. lusitaniae and C. kefyr) = pink colonies• White colonies characteristic aspect = orientation towards yeasts or filamentous fungi

chromID SalmonellaIncubation: 24 hoursS. Typhimurium ATCC 14028

chromID CandidaIncubation: 24 hoursC. albicans ATCC 10231, C. glabrata, C. krusei ATCC 6250

C. krusei

C. albicans

S. Enteritidis, P. vulgaris


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18* For more details see technical sheets

chromIDTM Strepto B2 for the screening of all S. agalactiaePrevention of Perinatal Group B Streptococcal disease

Original Principle• Three chromogenic substrates to optimise the identification of all gr. B Streptococcus = pale pink

to red colonies which are round and pearly after 18-24 hour incubation*.• Excellent performance for the GBS prenatal screening in terms of nutrient capacity and sensitivity

of detection.• Detection of all GBS strains, including non ß-hemolitic strains.• Differentiation of mixed cultures.• Selective inhibition of most bacteria not belonging to the species S. agalactiae, as well as yeasts.

Greater Simplicity: Incubation in aerobic conditions.

chromID Strepto BIncubation: 24 hours

S. agalactiae NCTC 8190

chromID S. aureusIncubation: 24 hours

S. aureus ATCC 25923

S. epidermidis (white colonies)

S. aureus (green colonies),S. saprophyticus (pink colonies),S. xylosus (mauve colonies)

Incubation: 48 hoursGBS vaginal specimen collection

Incubation: 24 hoursGBS vaginal specimen collection

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chromIDTM S. aureus2 for the the direct identification of S. aureus

Direct identification of S. aureus is based on the spontaneous green colouration of glucosidase-producingcolonies (patent pending).Greater Rapidity with the immediate identification of S. aureus = Green colonies (reading between 18 and 24 hours).

Greater Reliability:• Excellent performance for the culture of S. aureus in terms of nutrient capacity, detection sensitivity

and colouration specificity.• Optimum differentiation of mixed cultures due to the presence of a 2nd substrate.• Orientation of identification towards Staphylococci*= S. epidermidis (white colonies),

S. saprophyticus (pink colonies), S. xylosus (mauve colonies).

Inhibition of other bacteria (Gram + and Gram -) and yeasts.

chromID S. aureus

Ref. 43 371 • kit of 20 plates

Slidex® MRSA

Ref. 73 117 • kit of 50 tests

chromID Strepto B

Ref. 43 461:kit of 20 plates

Todd Hewitt Broth+ Antibiotics

Ref. 42 116:kit of 20 tubes of 9 ml

SLIDEXStrepto Plus B

Ref. 58 819:kit of 50 latex tests

SLIDEX Strepto Plus

Ref. 58 810:kit of 50 latex tests

* For more details see technical sheets

chromIDTM Vibrio*

2 for the selective isolation of Vibrio

Presumptive identification of V. cholerae is based on the blue-green colouration of beta Galactosidase-producing colonies.

Differentiation of V. parahaemolyticus: Pink colonies based on arabinose assimilation.

chromID O157:H7

Ref. 42 605 • 6 x 200 ml bottles

cefixime tellurite mixture

Ref. 42 606 • 6 x 4 ml vials

chromID Vibrio


chromIDTM O157:H72 for the selective isolation and presumptive identification of E. coli O157:H7

chromID O157:H7, an innovative chromogenic medium enabling easy differentiation between the O157:H7 serotype and other microorganisms:

• identification of E. coli O157:H7 after only 24 hrs of incubation at 37°C

• characteristic green to blue-green colour of E. coli O157:H7 colonies

• more fertile than SMAC medium, and equally selective

• inhibition of Gram-positive bacteria and yeasts

• increase in selectivity with respect to Gram-negative bacteria by adding Cefixime Tellurite, for highly contaminated samples.

chromID VibrioIncubation: 24 hoursV. cholera

chromID O157:H7Incubation: 24 hoursE. coli O157:H7ATCC 43890Citrobacter freundiiATCC 8090E. coli ATCC 11229Proteus mirabilis ATCC 12453

Citrobacter - ProteusOther E. coli

E. coli O157:H7

E. coli O157:H7

Vibrio parahaemolyticusIncubation: 24 hours


* Consult your local bioMérieux representative for more product information and availability.�

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Fecal culture naturally contaminated by V. cholerae.

Images from Dr Scheftel, Institut de Bactériologie,

Strasbourg, France.

chromID P. aeruginosa


chromIDTM P. aeruginosa*

2 for the direct identification of Pseudomonas aeruginosa

The direct identification of P. aeruginosa is based on the specific pink to violet coloration of aminopeptidase-producing colonies due to the chromogenic substrate ß-alanyl-resorufamine(2 bioMérieux patents).

* Consult your local bioMérieux representative for more product information and availability.�

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chromID P. aeruginosa

Incubation: 24 hoursP. aeruginosa

ATCC 27853

Visualisation of golden-metallic coloured P. aeruginosa colonies.

P. aeruginosa morphotypes in cystic fibrosis specimens.

You need rapid and easy detection of MDRO* responsible forthe most frequently found Healthcare Associated Infections.

You recognise our expertise in culture, identification and susceptibility testing. We naturally designed a specific rangeof MDRO chromogenic media to meet your everyday needs.

This range will help you:• Reduce the number of infections by avoiding:

- cross transmission between patients through isolation - auto-infection of colonized patients.

• Adjust the antibiotic surgical prophylaxis depending on the patient Multidrug-Resistant Organisms colonization status.

• Optimize the use of isolation beds.• Control the level of antibiotics resistance.• Provide healthcare cost-effectiveness.

* Multidrug-Resistant Organisms

S C R E E N I N G O F M U L T I D R U G - R E S I S T A N T O R G A N I S M S

Isolate Colonies& Start Patient Isolation

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chromID MRSA


Enrichment broth

Heart-Brain brothRef. 42 081 • kit of 20 tubes

Todd-Hewitt broth + antibioticsRef. 42 116 • kit of 20 tubes

Agglutination Tests

Slidex® Staph PlusRef. 73 115 • kit of 50 testsRef. 73 116 • kit of 250 tests

Slidex MRSA DetectionRef. 73 117 • kit of 50 tests

Stronger green coloration of colonies when plates read

upside down through the plate bottom

chromID MRSAIncubation: 24 hours

S. aureus ATCC 43300

MRSA positive specimencollection.Image from Dr. C. Nonhoff,Erasme Hospital, Belgium

MRSA nasal specimencollection.Image from D. Blanc, CHUV Lausanne

MRSA from a nasal swabspecimen. Image provided by Sullivan& Nicolaides Pathology,Brisbane, Australia

2 C H R O M O G E N I C M E D I A F O R T H E S C R E E N I N G O F M U LT I D R U G R E S I S TA N T O R G A N I S M S

chromIDTM MRSAInnovative, specific chromogenicmedia range

2 for the direct screening of methicillin-resistant S. aureus (MRSA) in 18-24 hours*

chromID MRSA is dedicated to the surveillance culture or screening of MRSA to identify hospitalizedpatients requiring isolation.The screening of MRSA carriers with surveillance cultures is a key step in the fight against nosocomialinfections.chromID MRSA has been developed to answer this major health concern.

Identification of MRSA strains is based on the spontaneous green colouration of α-glucosidase-producing colonies (patent pending) and the presence of an antibiotic, cefoxitin.

Greater Rapidity:Extremely easy-to-read identification of MRSA = Green colonies after 18-24 hour incubation.

Greater Reliability:• Excellent performance for the screening of MRSA in terms of nutrient capacity, detection

sensitivity and colouration specificity.• The presence of cefoxitin enables the detection of MRSA strains including hetero-resistant strains.• The selective mixture inhibits most bacteria not belonging to the genus Staphylococcus,

as well as yeasts.

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23* For more details see technical sheets

Vancomycin Bio-DiscsTM

Ref. 54 912 • kit of 4 boxesof 50 x 6mm impregnated discswith Vancomycin 30µg concentration

Heart-Brain broth


chromID VRE


chromIDTM VRE2 for the screening of E. faecium and E. faecalis showing acquiredVancomycin resistance (VRE)

chromID VRE (patents pending) contains two chromogenic substrates (α-Glucosidase & ß-Galactosidase) and Vancomycin (8mg/l) which enable:• Direct identification of E. faecium and E. faecalis after 24 hour incubation. • Specific and selective isolation & detection of acquired Vancomycin-Resistant enterococci.• Characteristic colouration of colonies with: Bluish-green colour = E. faecalis - Violet colour = E. faecium

The selective mixture inhibits:- enterococci with natural resistance (ie. E. casseliflavus and E. gallinarum…)- most Gram-negative and Gram-positive bacteria as well as yeasts.

chromID VREIncubation: 48 hoursE. faecium CCUG 36804,E. faecalis ATCC 51299

chromID ESBLIncubation: 18-24 hoursE. coli CIP 103982,K. pneumoniae ATCC 700603,P. mirabilis ATCC BAA-896

Incubation: 24 hoursK. pneumoniae

ATCC 700603

Incubation: 24 hoursE. coli CIP 103982

E. faeciumVRE feces specimen

collections

E. faecalisVRE feces specimen

collections

2 C H R O M O G E N I C M E D I A F O R T H E S C R E E N I N G O F M U LT I D R U G R E S I S TA N T O R G A N I S M S

chromIDTM ESBL2 for the screening of Extended-Spectrum ß-lactamase producingEnterobacteria (ESBL)

chromID ESBL agar (patent pending) contains:• A mixture of antibiotics, including cefpodoxime, enabling the selective growth of ESBL-producing

enterobacteria.• Two chromogenic substrates and one natural substrate enabling the direct identification of the most

frequently encountered ESBL-producing enterobacteria. - Escherichia coli: spontaneous coloration (pink to burgundy) of ß-glucuronidase-producing strains

(ß-GUR). - Klebsiella, Enterobacter, Serratia, Citrobacter (KESC): spontaneous green, brownish-green or blue

colouration of strains expressing a ß-glucosidase (ß-GLU). - Proteeae (Proteus, Providencia, Morganella): spontaneous dark brown to light brown colouration

of strains expressing a deaminase.

Whereas identification to the species or group level is direct,ESBL production must be confirmed by one or moreadditional tests.

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chromID ESBL


Incubation: 24 hoursS. pyogenes ATCC 19615

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Columbia agar + 5% sheep blood


Columbia agar + 5% sheep blood2 Isolation of fastidious bacteria2 Detection of hemolysis

Columbia agar is an isolation medium specially designed to facilitate the growth of fastidiousmicroorganisms.

Supplemented with sheep blood, it is highly nutritious and therefore adapted to the culture of most bacterial species, regardless of their metabolism.

2 B LO O D A G A R : C O M P L E X , S E L E C T I V E A N D D I F F E R E N T I A L M E D I A

Blood agarBlood agar are isolation media specially designed to facilitate the growth of fastidious microorganisms, Gram-positive bacteria and all the speciesencountered in clinical specimens.

It contains a peptone mixture particularly adapted to the culture of fastidious microorganisms (streptococci, Listeria...).The presence of blood enables hemolysis determination, which is a basic criterion for the orientation of bacterial identification.

Example of characteristic hemolyses:Streptococcus pneumoniae: a-hemolysis, with a greenish colouration around the colony.Streptococcus pyogenes: ß-hemolysis, with a clear zone around or under the colony.

Blood agar can be used to subculture bacterial strains in order to obtain pure cultures.

Columbia agar+ 5% sheep

bloodIncubation: 24 hours

S. pneumoniæ ATCC 6305

Columbia CNA agar + 5% sheep blood


Columbia agar + 5% horse blood


Columbia agar + 5% horse blood2 Isolation of fastidious bacteria2 Detection of hemolysis

Columbia agar + 5% horse blood is an isolation medium which has been developed to facilitate the growth of fastidious microorganisms.

Columbia agar+ 5% horsebloodIncubation: 24 hoursL. monocytogenes ATCC 35152

Columbia CNAagar + 5% sheep bloodIncubation: 48 hoursS. pyogenesATCC 19615

Incubation: 48 hoursS. aureus

ATCC 25923

Incubation: 48 hoursS. pyogenes ATCC 19615 +S. pneumoniæ ATCC 49619

(x 2.5)


Columbia CNA agar + 5% sheep blood2 Selective isolation of fastidious bacteria2 Detection of hemolysis

Columbia CNA agar + 5 % sheep blood is a selective isolation medium which enables the growth of Gram-positive bacteria commonly encountered in clinical specimens.

Most Gram-negative bacteria and Bacillus are inhibited by the nalidixic acid and colimycin in the agar.

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Incubation: 48 hoursN. gonorrhoeæ ATCC 43069,S. pneumoniæ ATCC 6305

Incubation: 24 hoursN. meningitidis ATCC 13090

Chocolate agar + PolyViteX


Chocolate agar + PolyViteXTM

2 Isolation of fastidious bacteria

Chocolate agar + PolyViteX is an isolation medium particularly recommended for the growth offastidious strains belonging to the genera Neisseria, Haemophilus, and Streptococcus pneumoniaeencountered in clinical specimens.

This medium is composed of a nutrient base enriched with factors X (hemin) and V (NAD) providedby the hemoglobin and PolyViteX.

This medium can be used to subculture bacterial strains in order to obtain pure cultures.

Storage: shelf-life includes 4 week storage at 15°-25°C.

Trypcase Soy Agar + 5% sheep blood2 Isolation of bacteria2 Determination of hemolysis

Trypcase soy agar + 5% sheep blood is an isolation medium which favours the growth of all the species currently found in clinical specimens.

Chocolate agar+ PolyViteX

Incubation: 48 hoursN. gonorrhoeæ ATCC 43069

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Trypcase soy agar + 5% sheep blood


Trypcase SoyAgar

+ 5% sheepblood

Incubation: 48 hoursS. pyogenes

ATCC 19615 +S. pneumoniæ

ATCC 63605

Chocolate agar + PolyViteX VCAT3


Haemophilus Chocolate 2 agar


Haemophilus Chocolate 2 agar2 Selective isolation of Haemophilus

Haemophilus Chocolate 2 agar is a selective medium for the isolation of the different Haemophilusspeciesfrom polymicrobial specimens of human origin.

This new formula is composed of a nutritive base enriched with factors X (hemin) and V (NAD)provided by hemoglobin and PolyViteX.

Isolation of Haemophilus species collected from the respiratory or genital tracts is often difficult due to the presence of large amounts of associated flora.

The selectivity of the media is obtained by the combination of antimicrobial and antifungal agents.

HaemophilusChocolate 2agarIncubation: 24 hoursH. influenzae ATCC 10211

Chocolate agar+ PolyViteXVCAT3 agarIncubation: 48 hoursN. meningitidis ATCC 13090

N. gonorrhoeæ ATCC 43069


Chocolate agar + PolyViteXTM VCAT3 agar2 Selective isolation of Neisseria gonorrhoeae & Neisseria meningitidis

Chocolate agar + PolyViteX VCAT3 agar is a selective medium for the isolation of Neisseriagonorrhoeae & Neisseria meningitidis from polymicrobial specimens (urogenital, oropharyngeal,CSF, blood cultures...).

The medium is composed of a nutrient base enriched with factors X (hemin) and V (NAD) provided by hemoglobin and PolyViteX. The enhanced selectivity of the medium is obtained by the combination of antimicrobial and antifungal agents.


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Prevention of Perinatal Group B Streptococcal disease

2 GRANADA media for the screening of S. agalactiae

The original principle - “Granada formulae are selective and differential media thatenable the detection and identification of GBS in clinical specimens. There are 100%specific for GBS. They use Granadaene to differentiate GBS from other pathogenicbacteria. The methotrexate, included in the formulae, increases pigment production.” Dr Manuel de la Rosa, creator of the Granada media.

Granada agar2 Selective agar for the screening and direct identification of S. agalactiae

Granada Biphasic broth

Incubation: 24 hoursS. agalactiae ATCC 12386

Granada agar


Todd-Hewitt broth + antibiotics

Ref. 42 116 • Kit of 20 x 9 ml tubes

Incubation: 24 hoursStreptococcus B (red to orange characteristiccolonies) & Enterococcus faecalis

Granada agarIncubation: 24 hours

S. agalactiae ATCC 12386

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2 S P E C I F I C M E D I A : S E L E C T I V E I S O L AT I O N F O R S P E C I F I C O R G A N I S M S

Granada Biphasic broth2 Selective broth for the screening and direct identification of S. agalactiae

Granada biphasic broth enables in a single test: Direct specimen inoculation - Culture -IdentificationHighly Economical: it provides significant time and workload savings

Total Flexibility:• the tube can be used both in labs or for delocalised patient sampling and inoculation followed

by immediate incubation of GBS within 18-24 hours • storage: 2-year shelf-life at room temperature • incubation takes place in an aerobic atmosphere

Granada Biphasic Broth


API® suspension MEDIUM

Ref. 70 640 • Kit of 100 ampoules(3 ml)

PSIpettes

Ref. 70 250 • Kit of 400 units (5 ml)

Sabouraud GentamicinChloramphenicol 2 agar


Dermatophytes agar*

Ref. 43 062 • kit of 20 platesIncubation: 72 hoursA. niger ATCC 16404

SabouraudGentamicinChloram-phenicol 2agarIncubation: 24 hoursC. albicans ATCC 10231

Incubation: 72 hoursAspergillus nidulans

Incubation: 72 hoursAspergillus flavus


Sabouraud Gentamicin Chloramphenicol 2 agar2 Selective isolation of yeasts and moulds

Sabouraud Gentamicin Chloramphenicol 2 agar is a selective medium recommended for the isolationof yeasts and moulds from polymicrobial specimens.

The new formula has increased nutrient capacity, colour intensity, sensitivity of detection andspecificity of colouration for fungi. The increased level of peptones and dextrose favours the growth of fungal strains.The presence of gentamicin inhibits most Gram-negative and Gram-positive bacteria.The presence of chloramphenicol improves the selectivity for certain species which may be resistantto gentamicin (streptococci, Proteus, etc.).The pH of the agar which is slightly acidic, favours fungal growth more than bacterial growth.

* Consult your local bioMérieux representative for further product information and availability.�

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Ureaplasma urealyticum

Mycoplasma hominis

INVERTED MICROSCOPE (OBJECTIVE X10)

A7 Mycoplasma agar


Urea-Arginine LYO 2

Ref. 42 508 • kit for 25 tests

A7 Mycoplasma agar2 Selective culture and enumeration of urogenital mycoplasma

A7 Mycoplasma agar is a selective medium for the culture of mycoplasmas, Ureaplasma spp.and Mycoplasma hominis from urogenital specimens. The Ureaplasma urealyticum species has beenseparated into two new species called Ureaplasma parvum and Ureaplasma urealyticum. For the use of this medium, they should both be considered as Ureaplasma spp.This medium combines a rich nutritive base containing peptones, horse serum and growth factorsfavouring the growth of mycoplasmas (cysteine, PoliViteXTM, arginine, urea).

The appearance of the mycoplasma colonies is as follows:• Ureaplasma spp.“Sea urchin” colonies: round colonies surrounded by a brownish-black precipitate (due to oxidationof manganese sulfate).• Mycoplasma hominis“Fried egg” colonies: round colonies with a protruding center surrounded by a lighter halo.An antibiotic mixture inhibits the growth of most Gram-positive and Gram-negative bacteriacontained in the specimen.

Campylosel agar2 Selective isolation of Campylobacter

Campylosel agar is a selective medium for the isolation of intestinal Campylobacter(C. jejuni and C. coli principally) from stools.

The presence of sheep blood favours the growth of the target species.The nutrient capacity is enhanced by the use of reducing agents.Good selectivity is ensured by the antibiotic and antifungal agents present in the medium whichinhibit the majority of bacterial and fungal contaminants.

Characteristic Campylobacter colonies are small and greyish, and sometimes spread along the inoculation streaks.

A7 Mycoplasma

agar

Campylosel agar


Campyloselagar

Incubation: 48 hoursCampylo jejuni

ATCC 33291

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SMAC agar


BCSA agar


BCSA agar2 Selective isolation of Burkholderia cepacia

BCSA agar (Burkholderia cepacia Selective Agar) is a medium recommended for the selectiveisolation and detection of the species Burkholderia cepacia complexe from clinical specimens ofmainly respiratory origin (sputum and bronchoalveolar washing) in patients suffering from cysticfibrosis.

The presence of a peptone base and sugars enable optimum growth of the microorganisms.Crystal violet and the antibiotics present in the medium inhibit most microbial species (inhibition of Pseudomonas species).A high volume of agar per plate enables good performance for culture at 72 hours.

BCSA agarIncubation: 48 hoursB. cepacia ATCC 25416

SMAC CT agarIncubation: 24 hoursE. coli O157:H7 ATCC 43894


SMAC CT agar2 Selective isolation of Escherichia coli O157:H7

The SMAC CT agar (Mac Conkey with Sorbitol) enables the detection and differentiation ofenterohemorrhagic Escherichia coli of serotype O157:H7, responsible for gastro-intestinal infectionsor diseases.According to epidemiological data, these types of pathology may also be induced by the O157:H- serotype (non-motile bacteria unlike the O157:H7 serotype).

The presence of sorbitol and tellurite enables the differentiation of E. coli O157:H7 which ischaracterized by colourless colonies with a brown centre. E. coli 0157:H7 strains might also generatecolourless colonies with a brown centre.The other E. coli fermenting sorbitol give pink to red colonies.The selectivity for Gram-positive bacteria and certain Enterobacteriaceae is ensured by cefixime, bile salts, crystal violet and tellurite.

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D-Coccosel agar


D-Coccosel agar2 Selective isolation of enterococci and group D streptococci

D-Coccosel agar (Bile Esculin Agar) is used for the selective isolation and differentiation ofenterococci and group D streptococci from polymicrobial specimens.

The characteristic colonies of enterococci and group D streptococci are colourless or grey andsurrounded by a black halo (hydrolysis of esculin).

The selectivity of the medium for Gram-negative bacteria is provided by sodium azide.Bile inhibits certain Gram-positive bacteria other than enterococci.

Cetrimide agar2 Selective isolation of Pseudomonas aeruginosa

Cetrimide agar is a selective isolation medium for the detection of Pseudomonas aeruginosafrom specimens of various origin.Cetrimide agar stimulates the production of pyocyanin and the fluorescence of P. aeruginosa.Its formula is an optimization of King’s A medium: the addition of a quaternary ammonium inhibitsmost other microorganisms.Characteristic colonies present a spontaneous pale green pigmentation and green fluorescenceunder ultraviolet light.

D-Coccoselagar

Incubation: 24 hoursE. faecalis ATCC 29212

Cetrimide agar


P. aeruginosa ATCC 10145, UV light

Cetrimide agar

Incubation: 24 hoursP. aeruginosa ATCC 10145

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Gardnerella agar


Gardnerella agar2 Selective isolation of Gardnerella vaginalis

Gardnerella agar is a selective isolation medium for the detection of Gardnerella vaginalis in genitalspecimens.Gardnerella vaginalis, alone or associated with certain anaerobic bacteria (Mobiluncus, Bacteroidesand Prevotella), is responsible for various urogenital infections.

The presence of human blood favours the growth of the species being tested for and produces ß-hemolysis around the colonies. ß-hemolysis obtained solely on human blood agar is highlyindicative of G. vaginalis.

The antibiotics included in the medium inhibit most Gram-negative contaminants and yeasts.

GardnerellaagarIncubation: 24 hoursG. vaginalis ATCC 14018

LegionellaGVPC agarIncubation: 5 daysLegionella pneumophila

Legionella pneumophila (x 2.5)


Legionella GVPC agar2 Selective isolation of Legionella

Legionella GVPC agar has been specially developed for the isolation from respiratory specimens ofmost Legionella species, notably those responsible for infections: Legionella pneumophila, which isthe species most frequently involved (Pontiac fever) but also L. bozemanii, L. longbeachae, L. dumoffii,L. jordanis, L. gormanii, L. anisa and L. micdadei.This selective medium also enables the enumeration of Legionella in water according to standardsT90-431 and ISO 11731.The activated charcoal absorbs any toxic substances in the yeast extract and stimulates the growth of Legionella.The ACES buffer stabilizes the pH of the medium at 6.9, which is the optimal pH for growth.The characteristic colonies of Legionella are grey-blue in colour but which can become off-white with age.They have a regular pinkish edge and, when observed under a binocular microscope, have a groundglass appearance.GVPC medium provides excellent inhibition of growth of Gram-positive bacteria, most Gram-negativebacteria, yeasts and moulds, through an optimized combination of three antibiotics.

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Legionella GVPC agar


Slidex® Legionella Kit

Ref. 73 120 • kit of 50 tests(not CE marked)

Clostridium difficile agar


Clostridium difficile agar2 Selective isolation of Clostridium difficile

Clostridium difficile agar is a selective isolation medium which is specially developed for the growthof Clostridium difficile in stool specimens.Clostridium difficile is a causative agent of Pseudo-membranous colitis and more generally of antibiotic-associated diarrhea.

The presence of sheep blood facilitates the growth of the species being tested for.The characteristic colonies are grey and sometimes spread along the inoculation streaks.The antimicrobial and antifungal agents in the medium inhibit most bacterial and fungalcontaminants.

Yersinia CIN agar2 Selective isolation of Yersinia

Yersinia CIN agar is a selective isolation medium for the detection and differentiation of differentspecies of Yersinia from stool specimens.

The formula of the medium is that described by Schiemann (CIN medium: Cefsulodin, Irgasan,Novobiocin).The mannitol and neutral red present in the medium enable Yersinia to be differentiated by the colour of the colonies (dark pink to red colonies).

The presence of cholate, deoxycholate, crystal violet, Irgasan and antibiotics inhibits the growth of Gram-positive and most Gram-negative bacteria.

Clostridium difficile agar

Incubation: 48 hoursC. difficile ATCC 9689

Yersinia CIN agar


Incubation: 48 hoursY. enterocolitica ATCC 9610

Yersinia CINagar

Incubation: 24 hoursY. enterocolitica

ATCC 9610

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Schaedler agar + 5 % sheep blood


Schaedler agar + 5% sheep blood2 Isolation of anaerobic bacteria

Schaedler agar + 5 % sheep blood is an isolation medium particularly suitable for the detection of obligate and facultative anaerobic bacteria.

The presence of growth factors such as yeast extract, hemin and vitamin K3 and the addition of sheep blood, enable the growth of ever most fastidious species.The reducing agent (L-cystine) and high concentration of dextrose in the agar favour the growth of anaerobic species.

Schaedler agar+ 5% sheepbloodIncubation: 48 hoursB. fragilis ATCC 25285

Pylori agarIncubation: 48 hoursH. pylori ATCC 43504

H. pylori ATCC 43504 (x 2.5)

Incubation: 24 hoursC. perfringens ATCC 13124

Incubation: 72 hoursVeillonella parvula

ATCC 10790


Pylori agar2 Selective isolation of Helicobacter pylori

Pylori agar is a selective isolation medium for the detection of Helicobacter pylori in gastric biopsies.Helicobacter pylori is a cause of gastritis and is associated with the development of gastric andduodenal ulcers.

Helicobacter pylori is a microaerophilic bacterium whose viability is reduced on contact with air.These characteristics should be taken into account for transport and culture.The presence of horse plasma and PolyViteX enhances the growth of the target species.The antibiotics present in the medium inhibit the majority of bacterial contaminants.

Pylori agar


Portagerm pylori


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Eosin-methylene blue agar


Eosin-methylene blue agar2 Isolation of Enterobacteriaceae

Eosin-methylene blue agar is a selective isolation and differentiation medium for the detection ofEnterobacteriaceae.It enables lactose- and/or sucrose-fermenting microorganisms to be differentiated from non-fermenting microorganisms.Eosin-methylene blue agar is used to detect enterobacteria in stools, urine or other biologicalspecimens.

Lactose (+) and/or sucrose (+) microorganisms produce dark purple colonies by acidification of themedium, which may be accompanied by a metallic sheen.Non-fermenting microorganisms produce colourless or slightly pinkish colonies.The presence of 2 stains inhibits the growth of Gram-positive bacteria.

BCP agar2 Isolation of common microorganisms

YBCP agar (Lactose agar with Bromcresol purple) is an isolation and differentiation medium for the development of all organisms commonly found in specimens of various origin.

It also differentiates lactose-fermenting organisms from non-fermenting organisms.Lactose (+) organisms produce yellow colonies by acidification of the medium.Non-fermenting organisms produce blue or colourless colonies.

Eosin-methylene blue

agar Incubation: 24 hours

E. coli ATCC 25922

BCP agar


BCP agarIncubation: 24 hours

E. coli ATCC 25922(yellow colonies)

&P. vulgaris ATCC 6380(colourless colonies)

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Drigalski agar2 Selective isolation of Enterobacteriaceaeand other Gram-negative bacteria

Drigalski agar is a selective isolation and differentiation medium used to identify Enterobacteriaceae and other Gram-negative bacteria in feces, urine or other biological specimens.

Microorganisms that ferment lactose form yellow or yellowish-green colonies; the others produce blue, green, or bluish-green colonies.

The presence of sodium deoxycholate and crystal violet inhibits the growth of Gram-positive.

MacConkey agar


Drigalski agar


Mac Conkey agar2 Selective isolation of Enterobacteriaceae and Escherichia coli

MacConkey agar with crystal violet is a selective isolation and differentiation medium for the detection of Enterobacteriaceae in specimens of various origins.

This medium is specially designed to detect the fermentation of lactose through a colour change to neutral red.• lactose (+) colonies: pink to red, sometimes surrounded by a halo of precipitated bile salts.• lactose (-) colonies: colourless or slightly beige.

The selectivity for Gram-positive bacteria is provided by bile salts and crystal violet.


Drigalski agarIncubation: 24 hoursE. coli ATCC 25922(yellow colonies)&Salmonella typhimuriumATCC 14028(blue colonies)

Mac ConkeyagarIncubation: 24 hoursE. coli ATCC 25922(pink colonies)&P. mirabilis ATCC 12453(colourless colonies)

2 S I M P L E M E D I A : I S O L AT I O N O F O R G A N I S M S

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SS agar2 Selective isolation of Salmonella and Shigella

SS agar is a selective isolation and differentiation medium recommended for the detection of Salmonella and Shigella species.The medium is inoculated from stool specimens, suspension of stools or an enrichment broth.

The medium detects lactose-fermenting and thiosulfate-reducing (production of H2S) colonies.Lactose-fermenting microorganisms produce pink colonies, the others give colourless colonies.H2S-producing microorganisms produce colonies with a black centre.• Colonies of Salmonella are colourless to pale yellow, with or without a black centre.• Colonies of Shigella are colourless to pale pink or orange-coloured without a black centre.

The inhibition of Gram-positive micro-organisms is obtained by a mixture of bile salts and stains.

Selenite F broth


Rappaport broth


SS agar


Selenite F broth


Rappaport broth


Hektoen agar


Hektoen agar2 Selective isolation of Salmonella and Shigella

Hektoen agar is a selective isolation and differentiation medium recommended for the detection of Salmonella and Shigella species.The medium is inoculated from stool specimens, suspension of stools or an enrichment broth.

Microorganisms that ferment one of the three sugars in the medium form yellow or yellowish-pink colonies; the others produce green to bluish-green colonies.H2S-producing microorganisms form colonies with a black centre.• Colonies of Salmonella are green to bluish-green, with or without a black centre.• Colonies of Shigella are green to bluish-green without a black centre.

Inhibition of Gram-positive microorganisms is obtained by a mixture of bile salts and stains.

Hektoen agarIncubation: 24 hours

Salmonella typhimuriumATCC 14028

SS agarIncubation: 24 hours

Salmonella typhimuriumATCC 14028

(colonies with black centre)

&S. flexneri

ATCC 12022(pale pink colonies)

S. flexneri ATCC 12022

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Mannitol Salt 2 agar2 Selective isolation of staphylococci

Mannitol Salt 2 agar is intended for the selective isolation of staphylococci in human specimens andorientation of identification of S. aureus.

The new formula has increased nutrient capacity, sensitivity of detection and specificity.

Micro-organisms which ferment mannitol produce yellow colonies.This characteristic is a criterion for orienting identification of Staphylococcus aureus.The high content of sodium chloride in the medium limits the growth of certain bacteria other thanStaphylococcus.


CLED agar


CLED Andrade agar *


Mannitol Salt 2 agar


CLED agar2 Isolation of urinary tract micro-organisms

CLED agar (Cystine Lactose Electrolyte Deficient) is especially useful for the isolation of urinary tractmicro-organisms.It also enables the differentiation of lactose-fermenting and non lactose-fermenting bacteria (bromothymol blue indicator).• Lactose (+) bacteria produce pale yellow to yellow colonies by acidification of the medium.• Non-lactose fermenting bacteria produce green, blue or colourless colonies.The composition of the medium (weak electrolyte content) prevents the swarming of Proteus.

The new CLED formula provides real advantages in terms of larger colony size, improvement of Lactose character reading, and better colony differentiation.

Mannitol Salt 2agarIncubation: 24 hoursS. aureus ATCC 25923

CLED agarIncubation: 24 hoursE.coli ATCC 25922(yellow colonies)&P. mirabilis ATCC 12453(colorless colonies)

2 S I M P L E M E D I A : I S O L AT I O N O F O R G A N I S M S

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40* Consult your local bioMérieux representative for further product information and availability.

Mueller Hinton 2 agar2 Susceptibility to antibiotics and sulfonamides

Mueller Hinton 2 agar is a medium for antimicrobial susceptibility testing by disc diffusion.

The composition of Mueller Hinton 2 agar enables the growth of non-fastidious bacteria(Enterobacteriaceae, non fermenting Gram-negative bacilli, staphylococci and enterococci) found inhuman pathology, while guaranteeing minimum interference from the constituents of the formulawith the result of the antimicrobial susceptibility test.

The concentration of divalent ions in the agar is adjusted to ensure a more accurate determinationof the susceptibility of Pseudomonas to aminoglycosides and tetracyclines.The low concentration of thymine – thymidine (sulfonamide inhibitors) restricts the growth aroundthe discs, enabling more accurate measurement of the zones of inhibition.

The use of Mueller Hinton 2 agar is in compliance with the NCCLS and CA-SFM standards.

Mueller Hinton 2 agar


Mueller Hinton 2 agar + 5% sheep blood2 Susceptibility of pneumococci and other streptococci to antibiotics andsulfonamides

Mueller Hinton 2 agar + 5% sheep blood is a medium for antimicrobial susceptibility testing by discdiffusion for strains requiring blood for their growth.The composition of Mueller Hinton 2 agar, supplemented with sheep blood, enables the growth ofbacteria such as pneumococci and other streptococci, while guaranteeing minimum interferencefrom the constituents of the formula with the result of the antimicrobial susceptibility test.The low concentration of thymine – thymidine (sulfonamide inhibitors) restricts the growth aroundthe discs, enabling more accurate measurement of the zones of inhibition.The use of Mueller Hinton 2 agar is in compliance with the NCCLS and CA-SFM standards.

Mueller Hinton2 agar + 5%sheep blood

Incubation: 24 hoursS. pneumoniae ATCC 49619

Antibiotics Oxacillin 1µg

Erythromycin 15 µg

Mueller Hinton2 agar

Incubation: 24 hoursE. coli ATCC 25922

Antibiotics Ampicillin 10 µg

Cephalothin 30 µg Gentamicin 10 µg

Nitrofurantoin 300 µg Trimethoprim / sulfamethoxazole

1.25 / 23.75 µg

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2M E D I A F O R S U S C E P T I B I L I T Y T E S T I N G

Mueller Hinton 2 agar +5% sheep blood


Count-Tact®

applicator

Bi-BoxTM andCount-Tact®

plates

2M E D I A F O R E N V I R O N M E N TA L C O N T R O L S : S U R FA C E S , A I R , W AT E R

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For use in unprotected areas

Count-Tact agar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 501 • kit of 20 platesCount-Tact GTS agar without neutralizers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 582 • kit of 20 platesCount-Tact Sabouraud Dextrose Chloramphenicol agar . . . . . . . . . . . . . . . . . . Ref. 43 580 • kit of 20 plates

For use in clean areas triple-wrapped irradiated media 3P range: Storage at 2°-25°C

Count-Tact 3P Irradiated agar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 691 • kit of 20 plates. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 699 • kit of 100 plates

Count-Tact Irradiated agar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 491 • kit of 20 plates. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 492 • kit of 100 plates

Count-Tact Irradiated Sabouraud Dextrose Chloramphenicol agar . . . . Ref. 43 581 • kit of 20 plates

For use in isolators resistant to disinfection by disinfectant agents (Peroxyd or PerAcetic Acid)

Irradiated ISOLATOR Count - Tact 3P agar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 597 • kit of 20 plates

Equipment (for plates 55mm)

The Count-Tact Applicator standardizes surface collections in terms of time and pressureCount-Tact Applicator . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 96 300The Bi-Box is a sterile box for collecting, transporting and incubatingBi-BoxTM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 96 301 • 10 sterile cases for Count-Tact plates

air IDEAL® is a aerobiocollector which guarantees effective measurement of aerobiocontaminationair IDEAL® 3PTM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 96 303

Count tact range plates 55mm: with neutralizers

surfaceCount-Tact® range

The reference in environmental microorganism detection and/or enumerationin hospitals

Count-Tact plates are 55mm in diameter and have a grid scored on the base.The convex agar meniscus enables direct application to the test surface, such as walls,floors, utensils, or employees, for hygiene controls.

Count-Tact plates are recommended to check critical control points in protected areas whenestablishing or revising microbiological surface monitoring techniques and programs inhospitals.

Count-Tact plates also can be used to control air, notably using an air sampler.

air IDEAL® 3PTM

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Legionella

For detection and numerationGVPC agar * . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 031 • kit of 20 plates. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 032 • kit of 100 plates

For confirmation of the Legionella genusBCYE with L-cysteine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 013 • kit of 10 platesBCYE without L-cysteine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 023 • kit of 10 plates

For identification of L.pneumophila et L.anisaSLIDEX® Legionella kit ** . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 73 120 • kit of 50 tests

Others

Enumeration of total viable aerobic microorganismsR2A agar. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 551 • kit of 20 plates

waterCulture media and an identification test in compliance with the ISO 11731, NF T 90-431 and NF T 90-461 standards.

air & environment90mm plates

For use in unprotected areas

Trypcase Soy agar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 011 • kit of 20 plates. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 019 • kit of 100 plates

Sabouraud Dextrose agar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 555 • kit of 20 platesSabouraud Dextrose Chloramphenicol agar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 596 • kit of 20 plates

For use in clean areas triple-wrapped irradiated media 3P range: Storage at 2°-25°C

Trypcase Soy 3P Irradiated agar. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 711 • kit of 20 plates. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 169 • kit of 100 plates

Trypcase Soy Irradiated agar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 131 • kit of 20 plates. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 556 • kit of 100 plates. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 557 • kit of 20 plates (140mm)

Trypcase Soy Irradiated agar with neutralizers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 562 • kit of 20 platesSabouraud Dextrose Irradiated agar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 43 554 • kit of 20 platesSabouraud Dextrose Chloramphenicol Irradiated agar . . . . . . . . . . . . . . . . . . Ref. 43 595 • kit of 20 plates

Equipment (for plates 90mm)

The Bi-Box is a sterile box for collecting, transoporting and incubatingBi-BoxTM 90 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 96 301 • 10 sterile cases

air IDEAL® is a aerobiocollector which guarantees effective measurement of aerobiocontaminationair IDEAL® 3PTM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ref. 96 302

* Consult your local bioMérieux representative for further product information and availability.** Not CE marked

Plates forenvironmental

control

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44

Automatedspecimen inoculation

Streaking AheadAn original, revolutionary applicator using high precision technology standardizes and maximizes colony inoculation: • Maximum agar surface inoculated• Optimum, pressure-controlled contact with the agar while

inoculating• Standard quantity of inoculum used every time

This simple device is at the heart of PREVI™ Isola. It will change the way you think about inoculation and laboratory workflow.

A True BreakthroughPREVI™ Isola is simply streaks ahead in automated specimen inoculation.

It revolutionizes front-end media processing tasks by:• Maximizing bacteria colony isolation• Standardizing plate inoculation & results• Streamlining your lab workflow

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45

chromIDTM CPS®

Automated inoculationE. coli ATCC 25922

chromIDTM

Candida Automated inoculation

with mixed culture:C. albicans,

C. tropicalis, C. krusei

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46

The following eight "Specimen Protocols"are intended to be used as guidelines for the maintypes of specimen encountered in your laboratory.They help you to position our culture media accordingto specimen type with between I to V choicespossible. The choices indicated are the most appropriate solution in terms of :

2 microorganisms tested

2 the examination performed

2 epidemiological data

2 cost / workflow ratio

Certain categories have been grouped together, particularly as far as specimen collections areconcerned. For example, the "genital protocol" is forboth men and women. The analysis procedure proposed should therefore be adapted to the specimen to be studied as not all the microorganismsindicated will necessarily be tested for.

Teaming our simple and practical protocols with ourextensive range of quality media provides you withan optimised workflow solution.

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48 2 Urine Protocol

49 2 Fecal Protocol

50 2 Genital Protocol

51 2 Suppuration Protocol

52 2 Throat Protocol

53 2 Sputum Protocol

54 2 Blood Culture Protocol

55 2 Cerebral Spinal Fluid Protocol

Specimen Protocol Guidelines“From Specimen to Plate”

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48

E.coli/ProteusEnterococcus

Enterobacteriaceae

Non-Enterobacteriaceae Staphylococcus Gr.B

Streptococcus Yeasts Streptococcus Corynebact.Gardnerella Mycobacteriaceae

chromIDTM

CPS®Columbia

CNAZiehl Kinyoun-Gabett

Löwenstein Jensen

Color Gram 2

UrilineTM

Uriline ColiUriline 3 Enterococcus

Slide/coverslide

ColetsosIII

IV

V

II

I

SYSTEMATIC ISOLATION SPECIFIC ISOLATION

ColumbiaCNAor

TSA

DrigalskiBCP

MacConkey

EMB

Columbia

CLED

chromIDCPS

ColumbiaCNA

2 U R I N E P R O T O C O L

OR OR

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2 F E C A L P R O T O C O L

CampylobacterYersiniaShigellaSalmonella RotavirusAdenovirusVibrioClostridium

difficileE. coli

O157H7E. coli

BCP

MacConkey

Drigalski

EMB

SMAC CT C. difficile chromIDTM

VibrioHektoenchromIDSalmonella

SS

Hektoen YersiniaCIN Campylosel

II

III

I


MacConkey

Rappaport

ENRICHMENT DIRECT

Selenite-F

Color Gram 2

Methylene blue

Slide/coverslide

C

hCG

10S

T

VIKIATM Rota-Adeno

OR

OR

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Neisseria Streptococcus /Staphylococcus Gardnerella Enterobacteriaceae

Non-Enterobacteriaceae Yeasts Mycoplasma Chlamydiae

ChocolatePolyVitexTM

VCAT3

Schaedler Haemophilus Chocolate 2

ColumbiaCNA

chromIDStrepto B

ChocolatePolyVitex

ColumbiaCNA

Columbiaor

TSABCP Sab Genta

Chloram 2

ColumbiaCNA

chromIDTM

S.aureus Gardnerella Mac Conkey

chromIDCandida

III

II

I

II

I

SYSTEMATIC ISOLATION

Todd Hewittbroth

Granadabiphasicbroth

ChocolatePolyVitex

Columbiaor TSA Granada Columbia

or TSATodd Hewittbroth

Anaerobes Haemophilus Listeria Group B StreptoPregnant woman

SPECIFIC ISOLATION

Gonoline Duo 2

MycoplasmaIST 2

2 G E N I TA L P R O T O C O LColor Gram 2

GiemsaPortagermTM

Slide/coverslide

QuickVue®

Chlamydiae Test

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51

2 S U P P U R AT I O N P R O T O C O LColor Gram 2PortagermTM

Amies agar

Staphylococcus Corynebacteria

chromIDTM

S. aureusColumbia

CNAMac

ConkeyChocolate

PolyVitexTMchromIDCandida

ColumbiaCNA

III

I

MannitolSalt 2 agar

ColumbiaCNA

Sab GentaChloram 2II


Streptococcus EnterobacteriaceaeNon-Enterobacteriaceae Anaerobes YeastsPasteurella

ColumbiaSheep

ColumbiaCNA

Schaedler Vit. K3

Schaedler

SchaedlerNeo Vanco

OR

OR

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52

StreptococcusIf necrotizing ulcerative

gingivitis (Vincent’s tonsillitis suspicion)

chromIDTM

S. aureuschromIDCandida

ColumbiaCNA


Sab GentaChloram 2 SchaedlerColumbia

CNAI

MannitolSalt 2 agar

III

TSA Sab GentaChloram 2II


Staphylococcus Neisseria / Haemophilus Yeasts Aspergillus niger

in earsCorynebacterium /Arcanobacterium

Haemophilus Chocolate 2

ChocolatePolyVitex

VCAT3

TSA

Loeffler

2 T H R O AT P R O T O C O LColor Gram 2PortagermTM

Amies agar

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53

2 S P U T U M P R O T O C O L

Streptococcus / S. pneumoniae

Schaedler

Haemophilus Chocolate 2

ChocolatePolyVitex


VCAT3

GVPC BCSA chromIDP. aeruginosa

MannitolSalt 2 agar

Sab GentaChloram 2

ColumbiaCNA

chromIDTM

S.aureusMac

ConkeychromIDTM

Candida

II

I

I


Staphylococcus EnterobacteriaceaeNon-Enterobacteriaceae Haemophilus Yeasts Mycobacteria

PortagermTM

AnaerobesAspergillus

(if immunocompromisedpatient)

Neisseria Branhamella Legionella Burkholderia

cepacia P. aeruginosa RSV

SPECIFIC ISOLATION

Sab GentaChloram 2

Löwenstein Jensen

Coletsos

RSV Direct IF

Color Gram 2

Giemsa

Ziehl (Kinyoun Gabett)

OR

QuickVue®

RSV Test

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��

54

III

III chromIDTM

Candida

Sab GentaChloram 2

TSA

SPECIFIC ISOLATION

BrucellaYeasts

(If yeasts observed upon direct examination)

EnterobacteriaceaeNon-

Enterobacteriaceae

Streptococcus /Enterococcus Staphylococcus Corynebacterium /

Listeria Campylobacter Neisseria / Haemophilus Anaerobes

ChocolatePolyVitexTM Schaedler


Columbiaor TSA

Slidex® Pneumo-Kit

2 B LO O D C U LT U R E P R O T O C O LColor Gram 2Blood culture

bottle

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55

2 C E R E B R A L S P I N A L F L U I DP R O T O C O L

Color Gram 2

Methylene blue

Slide/coverslide

Neisseria /Haemophilus

Yeasts C. neoformans

(If yeasts observed upondirect examination)

chromIDTM

CandidaMac

ConkeyChocolate

PolyVitexTMI

Sab GentaChloram 2II


Streptococcus /S. pneumoniae Listeria Staphylococcus

EnterobacteriaceaeNon-

EnterobacteriaceaeMycobacteria

ChocolatePolyVitex

VCAT3

Slidex® Meningite Kit 5

Slidex Meningite Strepto B

Slidex Meningite MnB / E. coli K1

Columbiaor TSA

Löwenstein Jensen

Coletsos

Ziehl Kinyoun-Gabett India Ink

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Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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