Meet the Speakers

Plenary 1: Variations in cancer risk

Cristian Tomasetti earned his Ph.D. in Applied Mathematics at the University of Maryland, College Park in 2010. He was then a postdoctoral fellow in the Department of Biostatistics of the Harvard School of Public Health, joint with the Department of Biostatistics and Computational Biology of the Dana-Farber Cancer Institute, until 2013, when he became an Assistant Professor in the Department of Oncology of the Johns Hopkins School of Medicine. He holds a joint appointment in the Department of Biostatistics of the Bloomberg School of Public Health, where he teaches the required first-year Graduate Probability Theory course for which he has received numerous teaching awards.Dr. Tomasetti is recognized internationally for his paradigm-shift contributions to the current understanding of cancer etiology and cancer evolution. He is also actively working on the development of novel methodologies for the estimation of cancer risk, as well as on the development of algorithms for the early detection of cancer.

Cristian Tomasetti, PhDAssistant Professor

Johns Hopkins University

Meet the Speakers

Plenary 2: Modeling cancer in the mouseDr. Tyler Jacks is a world leader in the field of cancer genetics and is known for his ground-breaking work on the development of genetically-engineered mouse models of cancer (GEMMs). Over the course of his academic career, he has published over 200 peer- reviewed papers along with numerous review articles and book chapters. Dr. Jacks graduated magna cum laude with a BA in Biology in 1983 from Harvard College before becoming a graduate student in the laboratory of Dr. Harold Varmus at the University of California, San Francisco, where he showed that ribosomal frameshifting during translation gives rise to the gag-pol protein of the Rous sarcoma virus, HIV-1 virus and mouse mammary tumor virus. He went on to demonstrate that a stem-loop structure and RNA sequence making up the frameshift site are required for efficient frameshifting in vitro. In 1998, Dr. Jacks returned to Cambridge, Massachusetts, to join Dr. Robert Weinberg’s group as a post-doctoral fellow at the Whitehead Institute, where he developed several GEMMs, including the Rb, p53 and Nf1 mice. In 1992, Dr. Jacks became an assistant professor in the MIT Department of Biology and a member of the MIT Center for Cancer Research, which became the Koch Institute for Integrative Cancer Research at MIT in 2011. Currently, he is the David H. Koch Professor of Biology, Director of the Koch Institute for Integrative Cancer Research at MIT and an Investigator at the Howard Hughes Medical Institute.The Jacks lab has focused on developing new methods for the construction and characterization of GEMMs of human cancer. His group has produced GEMMs with constitutive and conditional mutations in several tumor suppressor genes, oncogenes, and genes involved in cell cycle control and apoptosis. Using these strains, the laboratory has developed models of various human tumor syndromes and cancer types, including Li-Fraumeni Syndrome, neurofibromatosis type 1, astrocytoma, retinoblastoma, pancreatic cancer, invasive colon cancer, soft tissue sarcoma, endometriosis, ovarian cancer and lung adenocarcinoma. These GEMMS have been used to examine the mechanism of tumor initiation and progression, to uncover the molecular, genetic and biochemical relationship to the human diseases, as tools to study response and resistance to chemotherapy, and to explore methods in molecular imaging and early detection of cancer. His laboratory has also extensively studied human tumor-derived cells, determined protein function in these cells, and related gene expression patterns in human cancers to their studies in mouse models. Novel pathways and processes that are critical for the progression of cancer have been discovered during these investigations.In recent years, the Jacks lab has moved into the burgeoning area of tumor immunology and utilizing GEMMs to understand the interactions between the immune system and cancer. In particular the lab has developed a mouse model of lung adenocarcinoma that harbors mutations in the Kras and p53 genes and that also expresses model T cell antigens, which serve as targets for tumor-specific T cells and stimulate anti-tumor immune responses. These models offer a unique platform for investigating how anti-tumor immune responses shape tumor gene expression, and importantly how tumor evasion mechanisms contribute to the development of advanced disease. Moreover, they are invaluable preclinical models for testing immunotherapeutics, as single agents, or in combinations with traditional or targeted therapies.Dr. Jacks has received numerous awards and honors for his contributions to the study of cancer genetics including the AACR Outstanding Achievement Award, the Amgen Award from the American Society of Biochemistry and Molecular Biology, the Chestnut Hill Award for Excellence in Medical Research, the Paul Marks Prize for Cancer Research, the Hope Funds for Cancer Research Award for Excellence and the Sergio Lombroso Award in Cancer Research. He was also a 2013 honoree of the MGH Cancer Center’s One Hundred celebration. Dr. Jacks served both as Chair and Member of the National Cancer Advisory Board at the National Cancer Institute as well as a member on the Board of Directors of the American Association for Cancer Research (AACR), where he was elected President of the organization in 2009. Dr. Jacks was also elected to the National Academy of Sciences, the Institute of Medicine of the National Academies, the American Academy of Arts and Sciences and the inaugural class of Fellows of the AACR Academy. Dr. Jacks serves as an advisor to several biotechnology and pharmaceutical companies. In 2015, he was the recipient of the Killian Award, the highest honor the MIT faculty can bestow upon one of its members. He is currently serving as director of the Blue Ribbon Panel for the National Cancer Moonshot Initiative, a working group of the National Cancer Advisory Board that provides expert advice to the task force lead by former Vice-President Biden.

Tyler Jacks, PhDDirector

Koch Institute for Integrative Cancer Research

Meet the Speakers

Plenary 3: Radiation and immunotherapySandra Demaria, MD, a native of Turin, Italy, obtained her MD from the University of Turin. She then moved to New York City for her post-doctoral training in immunology as a Damon Runyon-Walter Winchell Cancer Research Fund awardee, followed by a residency in anatomic pathology at New York University School of Medicine. She remained on the faculty at NYU School of Medicine, where she was an attending pathologist in the breast cancer service, an independent investigator and co-leader of the Cancer Immunology program of NYU Cancer Institute until 2015, raising to the rank of Professor. She is currently Professor of Radiation Oncology and Pathology at Weill Cornell Medicine Medical College where she leads a NIH-funded laboratory.

Dr. Demaria is internationally known for her studies demonstrating the synergy of local radiation therapy with different immunotherapeutic agents in pre-clinical models of cancer. She was the first to show that radiotherapy can convert breast tumorsunresponsive to immune checkpoint inhibitors into responsive ones. She has been working in partnership with Dr. Silvia Formenti for the past decade to develop a novel treatment paradigm exploiting the immune adjuvant effects of radiotherapy and translate the pre-clinical findings to the clinic.

Dr. Demaria's current work is aimed at identifying the molecular mechanisms that regulate ionizing radiation’s ability to generate an in situ tumor vaccine in preclinical tumor models as well as cancer patients treated in clinical trials testing various combinations of radiation and immunotherapy. As a breast cancer pathologist Dr. Demaria has also studied the immunological microenvironment of breast cancer in patients, and therapeutic strategies to modulate the immune infiltrate in preclinical breast cancer models.She holds leadership positions in national professional societies, including the Society for Immunotherapy of Cancer (SITC) where she currently serves on the Board, and is a member of the Steering Committee of AACR Cancer Immunology Working Group. She is also anelected member of the European Academy for Tumor Immunology (EATI), and serves in the editorial board of several journals, including Radiation Research, The Journal of Immunology, Clinical Cancer Research, and Journal for ImmunoTherapy of Cancer.

Sandra Demaria, MD Professor of Radiation

Oncology and PathologyWeill Cornell Medicine Medical

College

Meet the Speakers

Plenary 4: Proton radiation therapy

Harald Paganetti, PhD, is the Director of Physics Research at the Department of Radiation Oncology at Massachusetts General Hospital and a Professor of Radiation Oncology at Harvard Medical School. He received his PhD in experimental nuclear physics in 1992 from the Rheinische-Friedrich-Wilhelms University in Bonn, Germany, and has been working in radiation therapy research on experimental as well as theoretical aspects since 1994.

He is internationally recognized as an authority on proton therapy and specifically on Monte-Carlo simulations of dose and biological effects, the latter including modeling of clinical relative biological effectiveness as well as late effects. He has authored and co-authored more than 120 peer-reviewed publications and has edited a book on Proton Therapy Physics. For his research leadership he received the 2013 A. Clifford Barger Excellence in Mentoring Award from Harvard Medical School. Dr. Paganetti has been awarded numerous research grants from the National Cancer Institute.

He serves on the editorial boards for the International Journal of Radiation Oncology, Biology, Physics as well as Technology in Cancer Research and Treatment. He is a member of numerous task groups and committees for various associations such as the American Association of Physicists in Medicine. Notably he is a member of the Radiation Physics Committee of the American Society for Therapeutic Radiology and Oncology. From 2009 to 2012 he was the Science Chair of the International Organization for Medical Physics. He is also a member of the Radiation Therapeutics and Biology Study Section at the National Cancer Institute.

Harald Paganetti, PhDDirector of Physics Research,

ProfessorMassachusetts General Hospital

Registration Type Early-Until June 22, 2018

Advanced-Until July 27, 2018

Late- Until September 7, 2018

Onsite- Begins September 22, 2018

RRS Full Member $595 $715 $845 $925

RRS Emeritus Member $420 $530 $725 $805

Non-Member $960 $1125 $1275 $1359

Accompanying Guest $89 $89 $89 $89

Scholar-in-Training Rates

RRS18 Registration Rates

Registration Type Early- Until June 22 Advanced- Until July 27 Late- Sept. 7 Onsite- Begins Sept. 22

RRS SIT Member $385 $515 $625 $655

RRS SIT Memberpresenting abstract

$285 $415 $525 $555

Student Non-Member $650 $750 $850 $925

Accompanying Guest $89 $89 $89 $89

RRS Member, Emeritus & Non-Member Rates

REGISTRATION CANCELLATION POLICY: Requests for cancellations must be received by August 23, 2018; a $25 cancellation fee will apply. Cancellations after this date are non-refundable. HOTEL CANCELLATION POLICY: All hotel reservations require a one night deposit to be collected at the time of booking. All cancellations requested prior to August 23, 2018 will receive a refund for the one night deposit. Cancellation after this date are non-refundable. A Meeting by Design strongly recommends the purchase of Travel Guard International Travel Insurance. ACCOMPANYING GUEST: The accompanying guest fee allows attendance at the Welcome Reception. Please note: children 12 and over need to be registered and will be charged accordingly. Children under 12 are free and do not need to be registered.

Traveling Chicago, IllinoisAirport: O’Hare International Airport (ORD)22.3 miles/51 minutes from Hilton Chicago

Public Transportation from O’Hare to the Hilton ChicagoSuper Shuttle: $31Taxi: $50Rental Car: Book your rental car through RRS’ preferred travel agency, The Travel Station. Call 800-522-8747.

ParkingSelf: $56/day, Valet: $70/day

Round Trip Airfare Estimates

- Tokyo $1140- UK $765- New York $175- Atlanta $270

Area Fun Facts• Chicago's downtown area is known as "The Loop.“• Chicago had the first steel-framed skyscraper, zipper, pinball game

and blood bank.• Walt Disney was born in Chicago in 1901. He studied drawing at

Chicago's McKinley High School and the Institute of Fine Arts.• Chicago has the largest collection of Impressionist paintings outside

of Paris.• The first Ferris wheel made its debut in Chicago at the 1893 World's

Columbian Exposition. Today, Navy Pier is home to a 15-story Ferris wheel, modeled after the original one.

- Boston $160- Los Angeles $360- Houston $190

Autumn in Chicago

The month of September is characterized by rapidly falling daily high temperatures, with daily highs decreasing from 80°F to 68°F over the course of the month, exceeding 89°F or dropping below 57°F only one day in ten.

Daily low temperatures range from 49°F to 61°F, falling below 38°F or exceeding 69°F only one day in ten.

The average probability that some form of precipitation will be observed in a given day is 41%, with little variation over the course of the month.

We suggest bringing a light jacket to account for changes in weather.

After Labor Day, Chicago beaches are officially closed until the following summer.

The Heart of America

Credit: © Choose Chicago

As a multicultural city that thrives on the harmony and diversity of its neighborhoods, Chicago today embodies the values of America's heartland-integrity, hard work and community and reflects the ideals in the social fabric of its 77 distinct neighborhoods. Being the third-largest city in the United States, there is something for everyone.

Grant Park- Soldier Field- Buckingham Fountain- Art Institute of Chicago- Museum Campus- Millennium Park

Lake MichiganState Street ShoppingThe Chicago TheatreNavy Pier

The Historic Hilton ChicagoThe Hilton Chicago hotel opened its doors in 1927 and has served as one of the city’s most revered addresses ever

since. Located on South Michigan Avenue and overlooking Grant Park and Lake Michigan, the hotel has been meticulously redesigned and restored in a way that preserves the magnificence of its early 20th Century style while

incorporating all of the 21st Century conveniences our guests expect.

Facility DetailsWorld Class Meeting Facilities in Chicago

From events for up to 2,400 guests to small sessions of 20, you’ll find the perfect downtown Chicago meeting space at the Hilton Chicago. • Over 234,000 sq.ft. of flexible meeting space• Grand Ballroom: a ballroom steeped in history

and featuring more than 12,000 sq. ft. of uninterrupted space

• Third Floor Conference Rooms: seven state-of-the-art rooms offer seating for 20 to 80 people

The team of seasoned sales professionals, conference services and catering managers will provide detailed assistance with all planning for a seamless experience all the way through!

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Group RatesRoom People Net Rate Tax

(17.4%)Total

King or 2 Queen 1-2 $194 $33.75 $227.75

King or 2 Queen 3 $219 $38.10 $257.10

King or 2 Queen 4 $244 $42.45 $286.45

Onsite Dining

Beaux-Arts style with a fresh contemporary design, showcasing a cuisine of local Midwest flavors with fresh produce and ingredients from our Executive Chef’s rooftop garden and Urban Farm plot, local crafted beer selection and hand crafted libations.

Enjoy Irish farm to fork fare, tap to pint favorites and live entertainment at Kitty O’Sheas. Overlooking Grant Park, Kitty’s is the perfect local spot –to share a pint, craft beer flight, traditional favorites like fish n’chips or modernized twists such as wild boar sloppy Joe’s – you’ll enjoy one of Chicago’s most coveted Irish Pubs.

An upscale restaurant and convenient culinary market catering to travelers “on the go” who seek fresh, healthy ingredients with high taste quality. From gourmet bites, fresh salads, artisanal sandwiches, pastry shop favorites, wine selections, craft beers, Starbucks, countless soda fountain options to an over-abundance of snacks.

720 South Kitty O’Sheas Herb N’ Kitchen

Area ActivitiesHow Far to Fun?

The Hilton Chicago is within walking distance of many of the town’s top tourist destinations:•Grant Park – across street from the main entrance•Lake Michigan – two blocks •Museum Campus featuring Shedd Aquarium, Field Museum and Adler Planetarium – five blocks •Art Institute of Chicago – five blocks •Millennium Park – five blocks •Chicago Loop Business & Financial District –five blocks •State Street Shopping – five blocks •Soldier Field – six blocks •Chicago Theatre – eight blocks •Magnificent Mile – two miles •Navy Pier – two miles

RRS18 Program Committee

• David Kirsch, Chair: Duke University

• Kevin Prise: Queen’s University Belfast

• Susan Bailey: Colorado State University

• Rebecca Abergel: Lawrence Berkeley National Lab

• Eric Chuang: National Taiwan University

• Juliann Kiang: Armed Forces Radiobiology Research Institute

• Chiara La Tessa: University of Trento

• Jan Schuemann: Massachusetts General Hospital

• Julie Schwarz: Washington University, St. Louis

• Henning Willers: Massachusetts General Hospital

• Audrey Rinehart: RRS-AMBD

• Veronica Haynes: RRS-AMBD

We invite you to join RRS for the next great scientific

meeting at the Historic Hilton Chicago Hotel.

SAVE THE DATESeptember 23-26, 2018

Registration Opens March 2018