POULTRY PRODUCTION SOLUTIONSConsistent Solutions for Ever Changing Production Demands

BACKGROUND

The Veterinary Feed Directive brought a wave of regulatory change

across animal agriculture influencing producers, nutritionists and

veterinarians to generate new strategies for antibiotic use. Additional

pressure on antibiotic use in meat production is being driven by retailer

and consumer demands with many companies already expanding the

amount of antibiotic-free product offerings. Although controversial, the

new paradigm of antibiotic use and push toward antibiotic-free (ABF)

production requires cooperation across all aspects of poultry production

to be successful. In 2016, Novus launched Project Horizon, an

initiative to help producers reduce the need for antibiotics in their

production systems. Project Horizon is an opportunity for Novus to

work in partnership with producers to optimize health through nutrition,

minimizing the need for antibiotic use. By addressing the nutritional

needs for health, both prevention and response to health challenge,

reliance on antibiotics can be reduced.

Designed to provide access to Novus’s expertise in gut health, nutrition

and management strategies, Project Horizon has a dedicated team

of resources and people available. Novus’s wide portfolio of solutions

helps optimize performance and improve animal health, animal well-

being, and profitability.

POULTRY PRODUCTION CHALLENGES AND SOLUTIONS

PATHOGEN EXPOSURE

NATURAL DEFENSES

MODULATE IMMUNE RESPONSE

INCREASED PATHOGEN LOAD WITHOUT ANTIBIOTIC TREATMENT

SOLUTION: DECREASE PATHOGEN LOAD

Physiological and environmental stress can alter intestinal gut flora, resulting in increased opportunity for pathogenic bacterial overgrowth leading to disease and poor performance. To encourage the predominance of beneficial bacteria, feed supplementation with high quality ingredients is essential in order to promote a healthy gastrointestinal tract to combat stressors. Enzymes, organic acids and probiotics have been proven to lower the levels of pathogenic bacteria in poultry, decreasing mortality and condemnations while improving live performance and profitability.

Enzymes aid in supporting a healthy digestive system and reducing nitrogen excretion levels. CIBENZA® DP100 protease shows a reduction in levels of C. perfringens and an improvement in intestinal villi strength through a reduction in systemic inflammation (Figures 1, 2). Protease enzymes also aid in digestion by breaking down non-digestible proteins, which reduces digesta viscosity, optimizing energy and efficiency while minimizing feed cost.

Organic acids are another strategy for fighting against C. perfringens and other pathogens. Research indicates ACTIVATE® WD decreases lesion scores and mortality rates in birds infected with necrotic enteritis (NE) by minimizing the impact and colonization of foodborne pathogens after establishing stable gut microflora (Figures 3, 4). ACTIVATE WD has also been proven to decrease the total percentage of Salmonella in the ceca improving overall gut health.

Nonmedicated

ACTIVATE WD 0.04%

ACTIVATE WD 0.08%

Salmonella Positive (%)

FIGURE 4. Less NE Lesion Scores in the Gut of Broilers, Challenged with Coccidia spp. and C. perfringens, After Supplying ACTIVATE WD MAX

FIGURE 3. Total Percentage of Ceca Salmonella Positive at 49 Days of Age

Lesi

on

Sco

res

at

D

ay

21

P<0.051.0

0.5

0.0Positive Control ACTIVATE WD MAX0 2010 30 5040

FIGURE 1. C. perfinges Counts in the lleum at 15 Days of Age

5.0

4.0

3.0

2.0

1.0

0.0Control High ProteinC

lost

rid

ium

pe

rfri

ng

en

s (l

og

cfu

)

With ProteaseWithout ProteaseYan et al., 2011

With ProteaseWithout Protease

FIGURE 2. CIBENZA DP100 Improves the Crypt:Villus After 14 Days of Age

0.20

0.16

0.12

0.08

0.04

0.00Control High Protein

Valu

e C

ryp

t:V

illu

s

Yan et al., 2011

Dibner et al., 2002Mead et al., 1999

When gut health is optimized, energy usage is targeted to gaining weight and increasing feed conversion. ACTIVATE® WD and MINTREX® chelated trace minerals work together to give birds an advantage in feed conversion as well as gain when suppressed by infection (Figure 8; Table 1).

Probiotics can be added to feed in order to beneficially alter and maintain a bird’s gut microflora for protection against harmful bacteria. SPORULIN®, a three strain direct-fed microbial, targets the production of bacteriocins and competes with pathogens for adhesion sites and nutrients along the GI tract, supporting gut development and health. SPORULIN research shows a decrease in mortality (Figure 5) by reducing the incidence and severity of NE. In addition to reducing the impact of NE on mortality and live performance, SPORULIN has been shown to reduce horizontal transmission of Salmonella (Figure 6) and reduce pathogenic E. coli (Figure 7) in broilers.

FIGURE 6. Horizontal Transmission in Broilers:Percentage of Salmonella Enteriditis Recovery

100

80

60

40

20

0Control Contacts SPORULIN Contacts

Liver/Spleen Ceca

Perc

en

tag

e (

%)

FIGURE 7. Population of E. coli F18 in the Gastrointestinal Tract of Broiler Chicks

CF

U o

f E

. co

li R

esi

stan

t to

N

alid

ixic

Aci

d (

Log

10)

7

6

5

4

3

2

1

0

Control

* Before E.coli F18 inoculation † Statistical difference (P<0.05)

SPORULIN

Day 1* Day 2 Day 5 Day 8 Day 11

FIGURE 5. Mortality Due to Necrotic Enteritis Decreases with SPORULIN

Mo

rtality

(%

)

18

15

12

9

6

3

0Starter (Day 0-14) Grower (Day 14-28) Finisher (Day 28-35) Withdrawal (Day 35-42) Day 42 Cumulative

Salinomycin Salinomycin + SPORULIN

Coccidiosis Vaccine Coccidiosis Vacci + SPORULIN

TABLE 1. Improved Feed Conversion and Live Weight Gain with ACTIVATE WD

Treatment Day 42 Day 49

Adj. Feed Conversion

Avg. Live Wt. Gain

Adj. Feed Conversion

Avg. Live Wt. Gain

Nonmedicated 1.797 2.557 kg 1.947 3.007 kg

ACTIVATE WD 0.04%

1.768 2.556 kg 1.900 3.013 kg

ACTIVATE WD 0.08%

1.772 2.557 kg 1.910 3.029 kg

Calvert et al., 2014

Stringfellow et al., 2012Internal Trial, 2013

Parker et al., 2011

FIGURE 8. Adjusted Feed Conversion of MINTREX Versus Other Sources

Ad

just

ed

FC

R

1.68

1.64

1.60

1.5640 ppm

Welch et al., 2015

Hydroxy TM SulfateAmino Acid Complex MINTREX

COMPROMISED STRUCTURAL INTEGRITY FROM INCREASED DISEASE

SOLUTION: BOOST STRUCTURAL INTEGRITY AND IMMUNITY

Bird development begins in ovo when the breeder hen transfers essential trace minerals to the embryo. The enrichment of the egg yolk with zinc, copper and manganese results in improved mineralization of the bone and connective tissue in the progeny. Zinc, copper and manganese are required to support collagen, elastin and keratin development that is essential for skeletal health.

Collagen and elastin make up approximately 30 percent of the total protein in birds and are essential for proper development, bird health and well-being. Hundreds of enzyme reactions depend on zinc, copper, and manganese.

Structural integrity includes immunity and cellular health. The challenges of a commercial production environment require birds to have optimal immune function. MINTREX® can lower lesion scores and boost gut health in birds challenged with disease (figure 9).

In addition to improvements in structural integrity, MINTREX chelated trace minerals have demonstrated improved immune

response to viral vaccines and have been shown to have a positive effect on plasma peroxide levels (Figure 10).

FIGURE 9. Improved Tissue Integrity of Birds Supplemented with MINTREX

45

40

35

30

25

20

15

10Day 46 Day 54

Control MINTREX

Gra

de 1

an

d 2

Fo

otp

ad

s, (

%)

FIGURE 10. Strengthened Immune Response with MINTREX

10.0

9.5

9.0

8.5

8.0

7.5

7.0

6.5

7.0

6.5

6.0

5.5

5.0

4.5

4.0

3.5ITM ITMMINTREX MINTREX

P=0.02 P=0.02

Ave

rag

e T

iter

Ave

rag

e T

iter

Infectious Bronchitis Newcastle Disease

ZnZINC

CuCOPPER

MnMANGANESE

found in every tissue of the body

accumulates in the bones

deficiency symptoms: poor growth and reproduction

required for crosslinking collagen

gives strength and elasticity in bone, shell and connective tissues

important for cartilage development

deficiency symptons: shortened, deformed skeletal structures and

slipped tendons referred to as perosis

Manangi et al., 2010 Internal Novus Trial

INCREASED FEED COST DUE TO POOR FEED QUALITY

SOLUTION: IMPROVE FEED QUALITY BY REDUCING FEED OXIDATION

Feed cost accounts for approximately 70 percent of the total cost of broiler production. Stabilization of fats, meals and dietary lipids is critical for production of high quality feed. Properly stabilized fats and ingredients reduce the oxidative loss of energy, vitamins and pigments in feed formulations and promote optimum performance and efficiency of poultry production. Unstabilized ingredients in feeds can result in a variety of gut health issues associated with feed passage and flushing, which in turn lead to poor performance, compromised bird health and increased production cost.

SANTOQUIN® feed preservative is proven to prolong the shelf life of feeds, especially during non-optimal storage conditions (i.e. excess heat, moisture, etc.), leading to improved weight gain and feed conversion rates.

SANTOQUIN is proven to improve feed conversion by two points and to reduce days to six pounds for production efficiency by 1.26 days (Figures 11, 12).

FIGURE 11. 2015 Data: Feed Conversion Ratio with Dried Distillers Grains in Diet

FIGURE 12. 2015 Data: Days to Six Pounds with Dried Distillers Grains in Diet

No SANTOQUIN SANTOQUIN

No SANTOQUIN SANTOQUIN

Average

Average

Jan-15

Jan-15

Feb-15

Feb-15

Mar-15

Mar-15

Apr-15

Apr-15

May-15

May-15

Jun-15

Jun-15

Jul-15

Jul-15

Aug-15

Aug-15

Sep-15

Sep-15

Oct-15

Oct-15

Nov-15

Nov-15

Dec-15

Dec-15

2 pts

1.26 Days

FC

RD

ays

1.90

1.88

1.86

1.84

1.82

1.80

1.78

1.76

1.74

47.0

46.5

46.0

45.5

45.0

44.5

44.0

43.5

43.0

IMPROVE weight gain and FCR

PROLONG SHELF LIFEduring non-optimal storage conditions

Broiler Industry Statistical Reporting Services, 2015

Broiler Industry Statistical Reporting Services, 2015

NOVUS SOLUTIONS FOR POULTRY HEALTH

A supplemental protease enzyme that optimizes digestion and absorption of nutrients, reducing the amount of anti-nutritive factors that pass through to the lower gastrointestinal tract.

A blend of organic acids that creates an environment to support positive microflora balance and helps mitigate bacterial shed and spread.

A direct-fed spore-based microbial that is an effective source of Bacillus subtilis that is proven to reduce pathogen levels and decrease feed conversion.

Delivers the most bioavailable sources of Zn, Cu and Mn for physiological functions including a stronger immune system, improved gut microflora balance as a result of Cu supplementation, and improved oxidative balance.

Manages gut level oxidative stress by stabilizing nutrients to support a healthy environment and improved animal oxidative balance for improved performance. SANTOQUIN also preserves the energy content of fats in complete feeds to optimize feed efficiency and reduce feed cost for gain.

Delivers antimicrobial properties and enhances performance as the leading source of methionine in the North America.

POULTRY PRODUCTION SOLUTIONSConsistent Solutions for Ever Changing Production Demands

Novus International, Inc. • 20 Research Park Dr. • St. Charles, MO 63304 USA • +1.314.576.8886 • www.novusint.com

Products not available in all countries.

NOTICE: While the information contained herein (“Information”) is presented in good faith and believed to be correct as of the date hereof, Novus International, Inc., does not guarantee satisfactory results from reliance upon such Information, disclaims all liability for any loss or damage arising out of any use of this Information or the products to which said Information refers and MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OF ANY OTHER NATURE WITH RESPECT TO THE INFORMATION OR PRODUCTS, except as set forth in Novus’s standard conditions of sale. Nothing contained herein is to be construed as a recommendation to use any product or process in conflict with any patent, and Novus International, Inc., makes no representation or warranty, express or implied, that the use thereof will not infringe any patent.

® , ALIMET, MHA, SANTOQUIN, CIBENZA, ACTIVATE, SPORULIN, ZORIEN,and MINTREX are trademarks of Novus International, Inc., and are registered in the United States and other countries.TM ACIDOMATRIX is a trademark of Novus International, Inc.© 2017 Novus International, Inc. All rights reserved.562_v1_R

Novus employs a dedicated team of employees and researchers committed to making poultry production more efficient and profitable in the face of ABF

production. The Novus staff has more than 50 PhDs and DVMs dedicated to helping poultry producers realize greater efficiency and profitability. Through partnerships with scientists and universities on a global scale, we invent custom solutions for

enhancing poultry health and producer profitability!

Join us on our journey with Project Horizon!