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POSITIONS OPEN

ASSISTANT PROFESSORTENURE-TRACK

MASSACHUSETITS INSTITUTEOF TECHNOLOGY (MIT)

DEPARTMENT OF CHEMISTRYThe Department of Chemistry invites applications for

a tenure-track position in organic chemistry. While thepreferred level of appointment is at the rank of AssistantProfessor, applications for appointment at more seniorlevels are also welcome. Outstanding individuals with astrong commitment to research and teaching are encour-aged to apply by arranging to have curriculum vitae, abrief description of research plans, and three letters ofrecommendation sent to: Professor Robert J. Silbey,Department of Chemistry, 18-399, MassachusettsInstitute of Technology, Cambridge, MA 02139-4307 by 15 October 1992.MIT is an Equal Opportunity/AffinnativeAction Employer

and encourages applicationsfrom minorities and women.

The Division of Endocrinology and Metabolism at theUNIVERSITY OF CALIFORNIA, IRVINE (UCI),invites applications and nominations for a tenure-trackFACULTY POSmON at the ASSISTANT PRO-FESSOR level. Candidates should have expertise inmolecular and cellular approaches to study aspects relatedto the endocrine system. Applicants must have an M.D.or M.D./Ph.D. degree, and have a strong record ofresearch accomplishments, with the potential to developan independent research program. The Division is com-mitted to excellence in endocrinology while providing afertile environment for interactive research at UCI andaffiliated institutions.

Interested applicants should send their curriculumvitae, a statement of research interest, and names andaddresses of at least three references to: Dr. MurrayKorc, Chief, Division of Endocrinology and Metabo-lism, Department of Medicine, UCI Medical Center,P.O. Box 14091, Orange, CA 92613-1491. UCI is anAffirmative Action/Equal Opportunity Employer.

RESEARCH ASSISTANT PROFESSORCandidates are sought for an assistant professor of

pharmacology (non-tenure research appintment) to su-pervise a research team investigating the role of proteinphosphorylation and turnover in carcinogenesis. Re-sponsibilities will include research protocol developmentand implementation and supervision of personnel. Noteaching or departmental administrative responsibilitiesare involved. Successful candidates will have experiencewith cell culture, protein purification, HPLC, and elici-tation and technical applications of antibodies. Familiar-ity with the application of molecular biology techniquesto study protein function in situ is also preferred. Appli-cants must have a Ph.D., appropriate postdoctoral train-ing, and a publication record demonstrating their pro-ductivity and expertise. Applicants should send curricu-lum vitae, names of three individuals who may becontacted for references, and a summary (not to exceedthree pages) of their research accomplishments to: MariK. Haddox, Ph.D., Department of Pharmacology,The University of Texas Medical School, P.O. Box20708, Houston, TX 77225. The University ofTexas isan Equal Opportunity Employer. Women and minorities areencouraged to apply.

STAFF POSITIONS IN IMMUNOLOGYSUPPORTED BY

THE LUCILLE P. MARKEYCHARITABLE TRUST

A tenure-track position at the ASSISTANT PRO-FESSOR level is available in the Division of Immunol-ogy of the Department of Pathology at New YorkUniversity School of Medicine (NYU).We are most interested in an applicant with a research

program in antigen processing, T cell functions, andtolerance mechanisms. However, we will consider anoutstanding applicant in other areas ofimmunology. Theposition provides a 5-year support package, which in-cludes the salaries of the investigator and a postdoctoralfellow, as well as funds for equipment and supplies.

Applicants should send curriculum vitae, a short state-ment of research interests, and names of three referencesto: Victor Nussenzweig, Division of Immunology,Department ofPathology, NYU Medical Center, 550First Avenue, New York, NY 10016.

POSITIONS OPEN

TRUDEAU INSTITUTE, INC.BASIC RESEARCH SCIENTISTS

INFECTIOUS DISEASES IMMUNOLOGISTA vacancy exists at the ASSISTANT PROFESSOR

LEVEL for an immunologist interested in employingmodern immunological techniques to analyze immunityto infections with microbial pathogens. The successfulapplicant will be supplied the resources to develophis/her independent research program within the overallinfectious disease program of the Trudeau Institute.Persons interested in developing models of immunity tointracellular pathogens are encouraged to apply. TheTrudeau Institute is a not-for-profit, basic research insti-tute. Salaries and benefits are competitive, and workingconditions are conducive to a productive research career.Applications consisting of curriculum vitae, the namesand addresses of three references, and a brief descriptionof research interests, should be addressed to:

Dr. Robert J. North, DirectorTrudeau Institute, Inc.

P.O. Box 59Saranac Lake, NY 12983

The Minnesota Dental Research Center for Biomate-rials and Biomechanics invites applications for a nonten-ure-track ASSISTANT PROFESSOR position (up to3-year term starting fall 1992) to conduct research innew formulations and structure-property relationships ofresin-based composites. Candidates must have a Ph.D. inchemistry or materials science, at least 1 year of postdoc-toral research experience, and peer-reviewed scholarlypublications. Research interest in biomimetics and or-ganic matrix-mediated mineralization advantageous.Some teaching to undergraduate/graduate students re-quired. Establishment of own sponsored major researchprogram expected. Applicants should submit curriculumvitae, copies of relevant publications, statement of re-search and career goals, and names and addresses of threereferences to: Dr. William H. Douglas, 16-212 MoosTower, Department of Oral Science, University ofMinnesota School of Dentistry, 515 Delaware Street,SE, Minneapolis, MN 55455. Deadline: 15 July 1992.The University of Minnesota is an Equal OpportunityEducator and Employer.

ASSISTANT PROFESSOR OF GENETICSDepartment of Biology at Long Island University's

Brooklyn Campus seeks assistant professor of genetics.Tenure track. Teach graduate and undergraduate cours-es. Research interests in areas ofmammalian genetics andeukaryotic cytology. Doctorate and teaching experiencerequired. Send letter of application, resume, and threeletters of recommendation to: Search Committee, coDr. Dennis Curley, Biology Department, Long IslandUniversity, University PIaa Brooklyn, NY 11201.Deadline for filing: 26 June 1992. Salary commensuratewith experience. An AffirmativeAction/Equal OpportunityEmployer.

ASSISTANT PROFESSORCELLULAR AND MOLECULAR BIOLOGYA tenure-track position is available in the Laboratory

for Cancer Research, Department of Chemical Biologyand Pharmacognosy, in the College of Pharmacy atRutgers University. Candidates with outstanding re-search and teaching ability in areas dealing with themolecular and cellular biology of the cancer cell areencouraged to apply. Areas o particular interest includemechanisms of carcinogenesis, factors influencing thestability of the cancer cell phenotype, factors influencingthe conversion of cancer cells to a normal phenotype,regulation of oncogenes, suppressor genes and growthfactors, the influence of normal cells on cancer cells,and/or the regulation of cell differentiation. Members ofthe department have strong interests in the areas ofchemoprevention of cancer, mutagenesis, chemical car-cinogenesis, cytochrome P450 regulation and function,mechanisms of retroviral evolution, SV40 interactionwith cellular targets and commitment to differentiation.Applicants should include curriculum vitae, three repre-sentative reprints, three letters of recommendation, and asummary of current research activities and future researchplans. Please send applications to: Dr. Allan H. Conney,Director, Laboratory for Cancer Research, College ofPharmacy, Rutgers University, P.O. Box 789, Piscat-away, NJ 08855-0789. An Affirmative Action/EqualOpportunity Employer.

SCIENCE * VOL. 256 * 5 JUNE 1992

CONDITIONS: Personnel advertising isaccepted only with the understanding that theadvertisers do not discriminate amongapplicants on the basis of race, sex, religion,age, color, national origin, handicap or sexualpreference. The AAAS encouragesemployers to actively recruit and employunderrepresented minority groups. Sciencereserves the right, at its discretion, to declineto publish advertisements submitted to it.

1468

Where do achievements in

energy get recognized?

Recently appointed national laboratory status byPresident Bush, the National Renewable EnergyLaboratory (NREL) formerly SERI, is entering a new

era of energy research. This elevated role has created

Senior/Staff Genetics ScientiLead genetics research to develop novel

ganisms for production of enzymes, fuelscals, and materials. Oversee activitiessuch as mutagenesis and metabolic paths

neering, maintain state-of-the-art capabilinteract with the professional conununity.Requires a PhD in molecular biology, t

5 istry, microbiology, or equivalent traindemonstrated experience in classical an

binant genetics technology applied to fition or enzyme producing microorganithe ability to lead a team in application cest technology in the field. Preferred is 'years relevant experience and an establientific reputation. Ref.#E4220-1025

Associate Genetics ScientistProvide technical assistance and support j

genetics scientists using mutageneses, j

nant DNA, and other techniques to ent

production of enzymes, fuels, chemicmaterials from biomass.Requires a Bachelor's degree in molectogy, biochemistry, or microbiology witdsis in genetics or equivalent relevant exdemonstrated experience using classicaland recombinant DNA technology iiDNA isolation and purification, analypreparative electrophoresis, ligation, tra

For in

Women

an unparalleled environment for our work and our

people. It's a perfect opportunity to join an innova-tive team committed to the development of cleaner,safer and renewable energy resources.

Rt tion restriction mapping and plate screening.

microor-

Preferred is 1-2 years experience in genetic modi-fication and screening techniques including expe-

s, cherru- rience in both radioactive and non-radioactivei areas methodologies, cloning bacterial cellulase and/orvay engi- work on expression vectors. Ref. # E4220-1026

Biochemical Research TechnicianSiochem- You will assist in the preparation of fermentationling with experiments using bench-scale apparati, bed recom- responsible for running and maintaining equip-ermenta- ment and associated instrumentation, and assist inssms, and the analysis of samples using chemical and bio-)f the lat- chemical techniques.5 or more Requires an Associate's or technical.degree or

shed sci- equivalent relevant experience as well as demon-strated knowledge of mathematics, and experi-ence as a chemical electronics, or mechanicaltechnician. Three - 5 years experience preferred

a team of along with demonstrated experience in the chemi-recombi- cal, biotechnology or food processing industries.iance the Familiarity with the operation and repair of labo-cals, and ratory equipment and instrumentation is also

desired. Ref.#E4210-1001ular biol- We offer an excellent compensation and bene-h empha- fits package. For immediate consideration,perience, please send your resume, indicating appropri-

genetics ate Reference Number, to: Humanncluding Resources Office, National Renewablertical and Energy Laboratory, 1617 Cole Blvd.,nsforma- Golden, CO 80401.

formation regarding current job opportunities at NREL,contact JOB LINE (303) 231-1192

and minorities are encouraged to apply. We are an equalopportunity employer.

NATIONAL RE N EWABLE ENE RGY LABORATORYI

Asscite

Directr

NATIONAL SCIENCERESOURCES CENTER

National Academy ofScies &Smithsonian on

The National Science Resource Center(NSRC) is seeking an associate director tomanage the NSRC outreach and informa-tion dissemination program. Responsibili-ties include managing a program of leader-ship development activities for educatorsand scientists; developing mechanisms toprovide technical assistance to school sys-tems; disseminating information about ef-fective K-12 science teaching resourcesand sources of assistance through resourcecollections, computer databases, and pub-lished resource guides; and developing anationwide database and telecommunica-tions network of regional, state, and localleaders working to improve the teaching ofscience in the schools. Position requiresPh.D. or equivalent in a scientific or techni-cal field, preferably related to pre-collegescience education, and at least 4 years ofdirectly related experience and interactionwith external and internal executives, lead-ers in science education reform, scientistsand engineers, and representatives frombusiness, industry, and private foundations.We offer a salary commensurate with expe-rience and an exceptional benefits package.Pleasesend resume in confidence to: DeputyDirector NSRC, Smithsonian InstitutionMRC-403, Arts and Industries Building,Room 1201, Washington, DC 20560. EOE.

NATIONALRESEARCHCCOUNCIL 'A

POSITIONS OPEN

The University of Nebraska College of Medicine,Department of Pediatrics, is seeking an ASSISTANTPROFESSOR of clinical toxicology. This appointmentwill have a joint faculty appointment in pharmacologicalsciences. Responsibilities will be to develop research intoxicology of metals. We seek an individual with a Ph.D.and at least 1 year of postdoctoral achievement as aninnovative investigator. Candidate must have a strongpublication record. Excellent facilities, equipment, andmaximum opportuniy for scientific growth. Send cur-rent curiulum vitae to: Carol R. Angle, M.D., Pro-fessor of Pediatrics, COP Room 1012, University ofNebraska Medical Center, 600 South 42nd Street,Omaha, NE 68198-6055. Position will be posted inJune 1992 and remain open until position is filled. TheUniversity of Nebraska is an Affirmative Action/EqualOpportunity Employer. Minorities and women are encour-aged to apply.

ASSISTANT PROFESSOR-ENTOMOLOGYUNIVERSITY OF MINNESOTA

The Department of Entomology, University of Min-nesota, is seeking applicants for a 12-month, tenure-track, extension-research position in urban entomology.The successful applicant will develop an active extensionprogram, with complementary research, on insect pestmanagement in the urban environment. A Ph.D. inentomology or related field and experience in outreacheducation and IPM research are required. Excellentcommunication skills, demonstrated extension and/orresearch productivity and experience in urban entomol-ogy are desired. Detailed position description available.Interested individuals should send a letter of application,statement of extension/research goals, curriculum vitae,transcripts plus names and addresses of five references by31 July 1992 to: Kenneth Ostlie, Search CommitteeChair, c/o Department of Entomology, University ofMinnesota, St. Paul, MN 55108. Telephone: 612-624-9272, FAX: 612-625-5299.The University of Minnesota is an Equal Opportunity

Educator and Employer.

SCIENCE EDUCATION COORDINATORCOLLEGE OF ARTS AND SCIENCES

UNIVERSITY OF DELAWAREApplications are invited for a tenure-track position at

the advanced ASSISTANT/ASSOCIATE PROFES-SOR level to direct the secondary science educationprogram. The position will be filled on or before 1September 1993.At the University of Delaware, College of Arts and

Sciences, departments administer secondary educationprograms, including those in biology, chemistry, earthsciences (geology and geography) and physics. The ap-pointment will therefore be made in the science depart-ment within the College of Arts and Sciences that bestreflects the scientific background and interests of thesuccessful candidate. Responsibilities will indude: (1)developing a research program concerned with recentadvances in the theory and practice of science education;(2) teaching courses in science education; (3) overseeingboth the academic advising and the student-teachingsupervision of science education majors; (4) initiatinggrant proposals for innovative preservice training andrn-service enrichment programs and projects; (5) partic-ipating in an existing campus-wide committee of sciencefaculty and science educators committed to the enhance-ment of science education; and (6) fostering productiverelationships between the state Department of PublicInstruction and science education interest groups withinthe local community and local industry.

Applicants must hold a doctorate with expertise inscience education and must demonstrate scholarly pro-ductivity in that subject area. Expertise in a sciencediscipline is also required. Opportunities will be availableto participate in graduate programs in science education.Curriculum vitae, a statement of present and futureresearch interests and the names of three individuals whocan provide letters of evaluation must be submitted by 1October 1992 to: David E. Sheppard, Ph.D., AssociateProfessor, Chair-Science Education CoordinatorSearch Committee, School of Life and Health Sci-ences, University of Delaware, Newark, DE 19716,telephone: 302-831-2782.The UNIVERSITY OF DELAWARE is an Equal

Opportunity Employer which encourages applications fromqualified minority group members and women.

POSITIONS OPEN

ASSISTANT PROFESSORPh.D. in Microbiology with a specialty in Infectious

Diseases required. Responsible for teaching InfectiousDiseases/Public Health course and weekly laboratories tomedical students. Emphasis on teaching excellence andteaching experience. Rank and salary commensurate withqualifications. All qualified applicants are encouraged toapply. Position starts August 1992. Send curriculumvitae and letters of recommendation by 6 July to: Dr.Lauritz A. Jensen, DA, Head, Department ofMicro-biology, The University of Health Sciences, 2105Independence Boulevard, Kansas City, MO 64124.Telephone: 816-283-2213. An Equal Opportunity/Af-firmative Action Employer.

RESEARCH ASSOCIATE PROFESSOR. Con-duct research on optical properties of semiconductingsuperlattices (SL) and quantum wells (QW), includingelectron states in GaAs/AlAs SL, nonlinear optical effectsin CdTe/CdZnTe QW and SL, and magneto-opticalmeasurements of semiconductors with time and aniaxial-stress modulations, utilizing research experience in elec-tro-optical and transport properties of semiconductorsystems (including GaAs properties, SL and QW, bandstructure, ODMR theory, deep levels involving latticerelaxation and multi-phono transitions), and techniquessuch as time-resolved optical spectroscopy (photolumi-nescence), Admittance and Fourier transform infraredspectroscopy, cathodoluminescence spectra and decay,deep level transient spectroscopy, and scanning electronmicroscope. Forty hours per week, 9 to 5; $30,000 peryear. Job in Hanover, New Hampshire. Requirements:Ph.D. in Solid-State Electronics and 2 years ofexperiencein job offered or as Research Associate with experienceidentified above. Send two resumes to: Job Order#92-59, P.O. Box 989, Concord, NH 03302-0989.

ASSISTANT/ASSOCIATE PROFESSORThe Department of Physiology and the Institute for

Environmental Medicine of the University of Pennsylva-nia Medical Center seek an experienced cell biologist/biochemist for a research-track faculty position based inthe institute.The successful candidate will interact with an estab-

lished program in lung cell and molecular biology and anindependent research program in mechanisms of exocy-tosis and/or phospholipid synthesis and intracellular pro-cessing. Excellent facilities are available.

Salary commensurate with experience. Send curricu-lum vitae, a statement of research interests and theaddresses of three references, by 31 July 1992, to:

DirectorINSTITUTE FOR ENVIRONMENTAL

MEDICINEOne John Morgan Building/606836th Street and Hamilton Walk

Philadelphia, PA 19104THE UNIVERSITY OF PENNSYLVANIA is an

Equal Opportunity/AffirmativeAction Employer.

PROFESSOR OF MEDICINE:HUMAN GENETICS

Harvard Medical School's Department of Medicine atthe Brigham and Women's Hospital is seeking to fill aPROFESSORSHIP (or tenured ASSOCIATE PRO-FESSORSHIP) in the field of human genetics. Candi-dates should possess an M.D. and/or Ph.D. and have awell-recognized research program in the broad area ofhuman genetics. Areas of interest might include but arenot limited to: (1) Identification of gene loci for specificheritable human disease; (2) diagnosis of genetic disor-ders, especially those involved in adult diseases; (3)biology of mutant alleles in the molecular pathogenesisofhuman disorders; and (4) gene therapy. In addition toleadership in research, candidates should possess anexcellent record of training young scientists in the field.

Harvard Medical School and the Brigham and Women'sHospital are Affirmative Action Employers. Women andminority scientists are encouraged to apply. Please sendcurriculum vitae and bibliography to: Dr. EugeneBraunwald, Chairman, Search Committee for Profes-sor of Medicine: Human Genetics, Brigham andWomen's Hospital, 75 Francis Street, Boston, MA02115.

SCIENCE * VOL. 256 * 5 JUNE 1992

HIEInnovation & Efficiency

Using innovation to improve theefficiency of molecular biology researchproducts has been the cornerstone ofStratagene's development since our

founding in 1984. With more than 200employees and 500 products, Stratagene

is now seeking two Postdoctora[Scientists to work at our beautiful La Jolla

(San Diego) headquarters.POSTDOCTORAL SCIENTISTSOne candidate should have experience incloning and expression of thermostableenzymes and extensive knowledge and

practical experience in nucleic acidenzymology and general molecular

biology techniques. Preference will begiven to motivated candidates with ahigh level of proficiency in recombinantDNA technology with training in nucleicacid modifying enzyme biochemistry.The other candidate should have

experience in Bacterial Genetics and/orMicrobiology and be available by

August I, 1992 or earlier.We offer a competitive salary, incentiveand benefits program. Please send your

resume and a letter of interest to:STRATAGENE, Attn: Professional

Staffing, 11099 N. Torrey Pines Rd., LaJolla, CA 92037. AA/EOE.

National Cancer Institute * National Institutes of Health * Public Health Service

CANCER PREVENTION FELLOWSHIP PROGRA

The Division of Cancer Prevention and Control (DCPC) isaccepting applications for the Cancer Prevention FellowshipProgram (CPFP). The purpose of this program is to trainindividuals from a multiplicity of health science disciplines inthe field of cancer prevention and control. The programprovides for: Master of Public Health training (at accrediteduniversities); Participation in the DCPC Cancer Preventionand Control Academic Summer Course; Working at NCIdirectly with individual preceptors on cancer prevention andcontrol projects; Field assignments in cancer prevention andcontrol programs at other institutions. Funding permitting, asmany as ten Fellows will be accepted for up to three years oftraining, beginning July 1, 1993. Benefits include selectedrelocation and travel expenses, paid federal holidays, andparticipatory health insurance.

ELIGIBILITY

M.D. or D.D.S. from a U.S., territorial, or Canadian MedicalSchool. Foreign medical graduates must have currentECFMG/FMGEMS certification and appropriate experience,e.g., one year residency in a training program approved bythe Accreditation Council for Graduate Medical Education.

OR

Ph.D., Dr. P.H. or other doctoral degree in a related discipline(epidemiology, biostatistics, and the biomedical, nutritional,public health or behavioral sciences). Foreign educationmust be comparable to that received in accredited U.S.,territorial, or Canadian institutions.

PLUS

U.S. citizenship or resident alien eligible for citizenship withinfour years.

For details and application catalog, send a postcard or letterwith your name and home address to:

Douglas L. Weed, M.D., M.P.H., Ph.D.Director

Cancer Prevention Fellowship ProgramDivision of Cancer Prevention and Control

Deadline for Receipt ofApplications:September 1, 1992

Further Inquiries: Mrs. Barbara Redding, (301) 496-8640

I2gd H [U1LgM KA12[U MI:I 12gI MI WI aN -0~-

Executive Plaza South, T-41, Bethesda, MD 20892 Z CO

NIH is an Equal Opportunity Employer

ProgenicsPharmaceuticals, Inc.

SENIOR SCIENTIST ANDPOSTDOCTORAL POSITIONS

Progenics PharmaceutIcals, Inc. is a blopharmaceuticaicompany specializing in the design and discovery oftherapeutics and vaccines to treat HIV infection. Applicationsare invited from scientists of the highest caliber with Ph.D.,M.D., or M.DJPh.D. degrees. A minimum of 2 years of

postdoctoral experience is required for Senior Scientistapplicants. Emphasis is placed on basic research andpublication in peer-reviewed Journals. Progenics collaborateswith investigators in laboratories throughout the United Statesand Europe. The research facilities are situated on a suburbancampus 20 miles north of New York City. Current researchinterests of the staff inciude:

Molecular biology and biochemistry of HIV and CD4 (the HIVreceptor); Virus attachment and entry; Mechanisms of virus-induced membrane fusion; Development of viral inhibitors; Modeof action of neutralizing antibodies; Development of HIVvaccines.

Candidates should send a curriculum vitae, a description of theirresearch experience and interests, and the names andaddresses of three references to:

Director, Human ResourcesProgenics Pharmaceuticals, Inc.

Old Saw Mill River RoadTarrytown, NY 10591

United States Biochemical Corporation, a leader in the supply ofreagents for molecular biology research, announces openings foroutstanding scientists in the areas of synthetic nucleic acid chemistryand molecular biology. Applicants should have demonstrated leadershipability and be capable of independent work. Applications will be consid-ered at all levels: Scientist, Principal Scientist, and Senior Scientist.Qualified applicants should have a Ph.D. degree and at least two yearsof postdoctoral experience, but applicants with equivalent expenencewill be considered.

Nucleic Acid ChemistsCandidates should have experience in synthetic nucleic acid chemistry.The successful applicant will be expected to function independently andsynthesize a variety of nucleotide analogues. Extensive experience innucleotide chemistry is therefore necessary.

Molecular BiologistsCandidates should have demonstrated expertise in cloning, mutagene-sis and expression in both prokaryotic and eukaryotic systems. Knowl-edge of eukaryotic cell culture and bacterial genetics is also desirable.The successful applicant will be expected to perform independentresearch involving the cloning, expression and mutagenesis of a varietyof genes and proteins as well as assist and advise the Production groupon problems related to the expression of proteins manufactured by USBand the storage and maintenance of the strains and plasmids used intheir production.USB is located in a pleasant suburb of Cleveland which offers easyaccess to the cultural centers of the city (the theater district and ballet,museums-including the excellent Cleveland Museum of Art and theworld-renowned Cleveland Symphony Orchestra) as well as access tonearby rural communities with excellent schools.If interested, please submit resum4, bibliography and names and phonenumbers of references to:

Manager of Personnel ServicesJC-1

United States Biochemical CorporationP.O. Box 22400

Cleveland, OH 44122EEO Employer M/VIH

* USBaUnhad Soaa EB yals

THESCIENCE RECRUITMENT"FOUR-DAY CLOSE"Now you can see your ad

in SCIENCE four daysafter submission

Scientific recruiters can now advertisepositions almost as soon as the need arises.Instead of reserving space a month or morein advance, you can now place your ad fourdays before the magazine mailing date.SCIENCE is mailed on the cover date.

Film (right-reading, emulsion face down)or full camera-ready art and insertion ordermust reach:SCiENCE, Attention: Daniel Moran, 1333 HStreet, N.W., Washington, DC 20005 byNOON Mondays (except for legal holidayswhen material must reach SCiENCE byNOON Fridays). Because space is limited,the four-day close page will be reserved on afirst-come, first-served basis, at a 15%premium. 1/4,1/2 or full page only.Now you don't have to wait to find the

researchers you need immediately, nor mustyou advertise in a Sunday paper that pans alot of sand but not much gold. Scientificemployers know that SCIENCE ads fill the jobbetter. Now they fill it faster too.

You can call it "INSTANT RECRUITMENT."

For further information, telephoneDaniel Moran, Advertising TrafficManager at SCIENCE: 202-326-6541,or write to:

SciENCEAdvertising Department,1333 H Street, N.W.,

Washington, DC 20005

CURRENT DISTRIBUTION 160,000

COLORADO

Research AssociateProtein Engineering

Somatogen, a biopharmaceutical company currently engagedin the development and manufacture of a recombinant humanhemoglobin, has an exciting opportunity available in our researchlaboratory. This individual will be self-motivated, with a desire tobe part of a team involved in cutting edge technology.

This position will be appointed to the Protein Engineering Group.Opportunities will exist for some experiments on functionalproperties and characterization of designed mutants.

The successful candidate will have a B.S. or M.S. in Biology,Molecular Biology or equivalent, plus a minimum of three yearsof appropriate experience. This individual will be experienced insite-directed mutagenesis, subcloning, polymerase chain reaction,and nucleic acid sequencing. Experience in routine proteincharacterization (SDS-PAGE, isoelectric focusing, etc.) andprotein purification would be helpful.

A competitive salary and benefits package complement this offer.Interested candidates may submit their resume and cover letterindicating, "Protein Engineening Position" to:Nancy Bomne, Manager, Professional Development.

5797 Central Avenue, Boulder, Colorado 80301An Equal Opportunity Employer

Public Health Service * National Institutes of HealthNational Institute of Environmental Health SciencesResearch Triangle Park, North Carolina

IRTA and STAFF FELLOWPOSITION(S)

Intramural Research Training Award (IRTA)) and Staff Fellow Positions areavailable in the Laboratory of Pulmonary Pathobiology at NIEHS/NIH.Opening for Ph.D. or M.D. with research experience in cellular andmolecular biology of inflammation and the regulation of expression ofinflammatory mediators and cytokines as well as their receptors. Alsoconsidered will be candidates with a strong background in the biochemistryand molecular control of extracellular matrix and cell adhesion molecules; inregulation of gene expression during differentiation of epidermalkeratinocytes, bronchial cells and embryonal carcinoma cells; and intranscriptional regulation by retinoic acid nuclear receptors and othertranscriptional factors. Experience in studies of receptor-ligand interactions,isolation and characterization of cytokines from tissue culture media or inthe techniques of in situ hybridization is highly desirable.REQUIREMENTS: Applicants must have an M.D. or Ph.D. in molecularbiology, biochemistry, cell biology, pharmacology or closely related field.Can idates with up to three years of postdoctoral experience may beconsidered for the IRTA Program, and applicants with up to seven years ofpostdoctoral experience may be considered for the Staff Fellowshiprogram. Salary commensurate with education and experience. For more

information, contact Dr. Paul Nettesheim, Chief, Laboratory of PulmonaryPathobiology, National Institute of Environmental Health Sciences, (919)541-3540.For prompt consideration, send cover letter indicating area of interest,curriculum vitae, and three letters of reference by December 1, 1992 to:

Ms. Carole Gregory (HNV48)NIEHS Personnel Office

P. O. Box 12233Research Triangle Park, NC 27709

NIH is an Equal Opportunity Employer

-

-

COLUMBIA UNIVERSITY

COLLEGE OF PHYSICIANS AND SURGEONS

DEPARTMENT OF MICROBIOLOGY

POS'1'TDOCTORAL FELLOWSHIPSThe Department of Microbiology Postdoctoral Fellowships are supported by anNIH Training Grant. Members of the Department and their research interests are:

KATHRYN CALAME, PH.D.Transcriptional regulation in B and Tlymphocytes.

MARIAN CARLSON9 PH.D.Gene regulation in yeast.

BERNARD ERLANGER, PH.D.Immunochemistry of nucleic acids; anti-idiotypic antibodies as probes of receptorstructure and function.

DAVID FIGURSKI, PH.D.Gene regulation and replication control inbacterial plasmids.

HAROID GINSBERG, M.D.Molecular mechanisms of virus pathogenesisand transformation.

STEPHEN GOFF, PH.D.Molecular biology of retrovirus replication;targeted gene disruption.

MAX GOTIESMAN, M.D., PH.D.Regulation of transcription in an E. coli.bacteriophage; study of gene regulation incultured rat thyroid cells.

ELVIN KABAT, PH.D.Antigen-antibody reactions; fine structure ofantibody and lectin combining sites; idiotypicspecificity.

AARON MITCHELL, PH.D.Molecular genetics of meiosis and its regulationin yeast.

BENVENUTO PERNIS, M.D.Cell dynamics of MHC; binding of peptides byMHC of viable cells.

VINCENT RACANIELLO, PH.D.Molecular biology of poliovirus and its cellreceptor.

PAUL ROTHMAN, M.D.Molecular mechanisms of immunoglobulinclass-switch.

DAVID SHORE, PH.D.Molecular mechanisms of gene regulation inyeast.

HOWARD SHUMAN, PH.D.Active transport; intracellular growth ofLegionella pneumophila.

SAUL SILVERSTEIN, PH.D.Control of gene expression in human herpesand papillomavirus infected cells.

ALAN STAIL, PH.D.Cellular immunology; regulation of Blymphocyte development and function.

LORRAINE SYMINGTON, PH.D.Genetics and biochemistry of DNArecombination and repair in yeast.

C.S. HAMiSH YOUNG, D.PHILViral genetics; recombination mechanisms;structure of viral promoters.

Send a letter indicating the investigator of interest, curriculum vitae and the names of threereferences to: Ms. Edith Shumansky, Department of Microbiology, Columbia University College ofPhysicians & Surgeons, 701 W. 168th Street, New York, N.Y. 10032. We welcome applicationsfrom minority individuals. Columbia University is an Equal Opportunity/Affirmative ActionEmployer.

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c

POSITIONS OPEN

ASSOCIATE PROFESSOR(Nutrition and reproductive/developmental biology).

The Pennington Biomedical Research Center (PBRC)and the Department of Animal Science, Louisiana StateUniversity (LSU), seek a scientist with a background intransgenic animal technology, molecular biology, growthand early development, or animal reproduction. This is aunique opportunity to develop and lead a research pro-

nutrition and reproductive or developmentalbiology. The Pennington Center is an ultra-modern,state-of-the-art laboratory and clinical research facility.Generous space and equipment package. Submit resumeand letter of application by 31 July 1992 to: EvelynBennett, Human Resource Management, PenningtonBiomedical Research Center, 6400 Perkins Road,Baton Rouge, LA 70808. LSU/PBRC is an EqualOpportunity Employer/Affirmative Action Employer.

NEUROPHYSIOLOGYASSISTANT/ASSOCIATE/FULL

PROFESSORSystems neurophysiologists are invited to apply for a

faculty position within The Philip Bard Laboratories ofNeurophysiology, Neuroscience Department, The JohnsHopkins University School (JHU) of Medicine. Appli-cations and inquiries should be sent to: Director, TheBard Laboratories of Neurophysiology, Departmentof Neuroscience, The Johns Hopkins School ofMed-icine, 725 North Wolfe Street, Baltimore, MD21205. JHU is an Equal Opportunity/Affirmative ActionEmployer.

CENTER FOR BLOOD RESEARCHHARVARD MEDICAL SCHOOLPROFESSOR OF PATHOLOGY

Harvard Medical School and the Center for BloodResearch are seeking a professor of pathology. Thesuccessful candidate will be expected to develop a majorresearch and training program in the biology of lympho-kines and their receptors, and participate in the tea ngof medical and graduate students. Candidates shouldhave demonstrated scholarly achievement and promise ofthe highest order. Harvard University is committed toincreasing representation of women and minority facultymembers and particularly encourages applications from suchcandidates. Candidates should send curriculum vitae andstatement of research interests to: Dr. Timothy Spring-er, Center for Blood Research, 800 Huntington Av-enue, Boston, MA 02115. An Affirmative Action/EqualOpportunity Employer.

CHIEF, LABORATORYSERVICE at the St. Lou-is VA Medical Center. We are seeking an experiencedPATHOLOGISTITEACHER with a record of schol-arly productivity. The position will include administra-tion of anatomic and clinical pathology, coordination ofacademic programs for residents, fellows and staff, andample opportunities for laboratory and clinical research.Candidates must qualify for a senior faculty appointmentat St. Louis University School of Medicine. Salary com-mensurate with qualifications. Send curriculum vitaeto: Lewis R. Chase, M.D. (IHjC), Chairman, SearchCommittee, VA Medical Center, St. Louis, MO63106. An Equal Opportunity Employer.

ECOLOGIST-EVOLUTIONARY BIOLOGISTThe W. K. Kellogg Biological Station of Michigan

State University (MSU) seeks to hire a PROGRAMCOORDINATOR for a new, NSF-funded researchtraining group in ecology and evolutionary biology.Primary responsibilities include coordination of a team-taught graduate course in ecological applications andparticipation in a summer program for high schoolstudents. The successful candidate will have a Ph.D. inecology and evolutionary biology and have a stronginterest in team approaches to teaching at graduate,undergraduate and precollege levels. The position willhold a specialist classification with a salary range of$35,000 to $40,000 per year. Please send a statement ofqualifications, curriculum vitae, and three letters of ref-erence to: RTG Search, W. K. Kellogg BiologicalStation, Hickory Corners, MI 49060, by 3 July 92or until a suitable candidate is selected. Women andminority members are encouraged to apply. MSU is anAffirmative Action/Equal Opportunity Institution.

1474

Share Our WorldwideCommitment To Discovery.

As one of the world's leading pharmaceutical companies, Eli Lilly andCompany has a vision for tomorrow: to enhance the discovery ofpharmaceuticals and expand our knowledge of medical research tobenefit people the world over. We've had a direct presence abroad formore than 70 years, and today our products are available in more than110 countries.

Supported by a research budget in excess of $700 million, our 4,000research scientists and technicians are pursuing a wide range ofimportant research projects. We're developing innovative therapiesfor cancer; cardiovascular, pulmonary, and skeletal diseases; diabetes;CNS conditions; and bacterial and viral infections.We are seeking qualified scientists for our discovery research divi-sion. Applicants should have a bachelor's or master's degree withresearch experience in biochemistry, pharmacology, biochemical phar-macology, bioanalytical chemistry, microbiology, pharmacokinetics,drug metabolism, physiology, molecular biology, or cell biology.If you share our vision for the future and our commitment to scientific

excellence, we invite your inquiry. For promptconsideration, please forward your resume to:Scientific Recruitment, Dept. S-692, Eli Lilly andCompany, Lilly Corporate Center, Indianapolis,IN 46285. An equal opportunity employer.

Cognitive NeuroscienceIndividual Grants-In-AidThe McDonnell-Pew Program in CognitiveNeuroscience is accepting proposals forindividual grants-in-aid to support researchand training in cognitive neuroscience.Applications are sought for projects ofexceptional merit that are not currently fund-able through other channels and from inves-tigators who are not at institutions alreadyfunded by the program. Preference will begiven to projects that are interdisciplinary incharacter involving two or more of thesubfields of cognitive neuroscience: clinicaland basic neuroscience, computer science,psychology, linguistics and philosophy.Research support is limited to a maximumof $30,000 per year for up to two years.Training grants and postdoctoral stipendswill be awarded at prevailing rates of thehost institution for up to three years.Training grants to support Ph.D. thesisresearch of graduate students will not befunded. Submissions will be reviewed by anadvisory board chaired by Professor GeorgeMiller of Princeton University.Applications must be postmarked on orbefore the deadline of August 1, 1992.For proposal guidelines contact: McDonnell-Pew Program in Cognitive Neuroscience,Green Hall 1 -N-6, Princeton University,Princeton, NJ 08544-1010, (609) 258-5014,fax: (609) 258-3031, email: cns@clarity.princeton.edu.

CENTRAL NERVOUSSYSTEM RESEARCHSan Diego, California

Gensia Pharmaceuticals, Inc. is an emerg-ing leader in research and development ofdrugs for the treatment of disease in theareas of central nervous system, cardio-vascular system, diabetes and inflamma-tion.We are seeking exceptionally talented sci-entists for our central nervous systemgroup involved in the rational design andevaluation of drugs targeted at stroke,epilepsy and other neurological disorders.Positions are available at the M.S. andPh.D. levels with degrees in physiology,pharmacology, biochemistry or related dis-ciplines in one or more of the followingareas: stroke models, seizure models, invitro electrophysiology, receptor binding,second messenger assays, behavioralpharmacology. Experience within thepharmaceutical industry is preferred.Gensia is a rapidly growing biopharma-ceutical company that offers an excitingresearch environment with competitivesalaries and generous benefits, includinga stock option plan. Please send CV to theattention of HUMAN RESOURCES-CNS,Gensia Pharmaceuticals, Inc., 1 1025Roselle Street, San Diego, CA 92121-1204, or Fax directly to 619/535-2758,Attention: B. Hockett.

EOEM,F,H,V.

G ENSIAUARMACUCAS, ANC

POSITIONS OPEN

DIRECTOR OF RESEARCHThe P/SL Healthcare System and Center for Health

Sciences Education seek an M.D. Ph.D., Pharm.D.,D.V.M., D.O., or D.P.M. researcher with experience inconducting clinical research to establish an Office ofResearch and Development. The system has two hospi-tals with 800 beds, an active medical staff numberingover 500, and centers of excellence in transplantation,oncology, limb preservation, geriatrics, cardiology, wo-men's services, and behavioral health. Our graduatemedical education programs are affiliated with RushUniversity in Chicago, the University of Colorado andthe College of Osteopathic Medicine of the Pacific.The director will be responsible for planning, develop-

ing, implementing, and evaluating the P/SL researchprogram. Candidates are invited to commit up to 30% oftheir time to their own research activities. At least 10years of experience in clinical research, knowledge ofbistatistics, strong interpersonal skills, and exceptionalwritten and verbal communication skills are required.

Send cover letter, curriculum vitae and references to:

Robert M. Rifkin, M.D.Chairman

Search Committee for Research & Developmentcdo Bone Marrow Transplant ProgramPresbyterian/St. Luke's Medical Center

1719 East 19th AvenueDenver, CO 80218

TEXAS, CHAIR, DEPARTMENT OF BIOMED-ICAL SCIENCES: Applications are invited for theposition of chairperson of the department of biomedicalsciences. Candidates should have strong academic cre-dentials in the biomedical sciences including a provenrecord of funded research. Candidates must have: (1) a

Ph.D., D.D.S. (D.M.D.)/Ph.D., or M.D./Ph.D. de-gree(s); (2) a record of teaching and research commen-

surate with a tenured professor at the institution; (3) a

strong commitment to academic excellence; (4) excellentcommunication and interpersonal skills to work effective-ly with internal and external constituencies; (5) experi-ence with predoctoral and graduate education; and (6)administrative experience. The successful candidate isresponsible for leadership, administration and coordina-tion of departmental activities including research anddental, dental hygiene and graduate student basic sciencecurricula development. This new department has beencreated from the recent merger of basic science depart-ments with teaching responsibilities in anatomy, bio-chemistry, cellular and molecular biology, microbiology,and physiology. Interested individuals should submit a

letter of apphation, curriculum vitae, and names andaddresses of three references to: Dr. Charles J. Arcoria,Chair, Search Committee, Baylor College of Dentis-try, 3302 Gaston Avenue, Dallas, TX 75246.

The Baylor College ofDentistry is an Equal Opportunity!Affirmative Action Employer.

CIBA-GEIGY has a major long-term commitment to thefield of asthma and allergy research and development ofnovel therapeutic agents for the treatment of asthma andrelated diseases. We are looking for

Recent PhDs

with an interest in Industrial research, a commitment toexcellence and the drive and ethusiasm to take on anddevelop novel research projects.

We are interested in candidates with a PhD in Pharma-cology or related subject with at least 2 years post-doctoral experience. Knowledge of and experience in thefield of pulmonary pharmacology/asthma is of value but isnot essential.

Please send your application under ref. "Science 9338"to Dr. U. Spaeti, CIBA-GEIGY Ltd., Personnel Dept., P.O.Box, CH-4002 Basel, Switzerland.

CIBA-GEIGY

.Synthetic Carbohydrate Drugs|Greenwich Pharmaceuticals has brought its lead compound, a novel synthetic carbohy-drate drug, into late Phase Ill development as a treatment for rheumatoid arthritis. With a

second compound in Phase I and others in preclinical development, we are breakingnew ground in carbohydrate technology.

Pharmacokineticist-Ph .D..Responsible for the development of preclinical pharmacokinetic/pharmacodynamic.(PKPD) programs in support of disposition studies of new drug candidates. This position.requies strong communication and leadership skills.

Pharmacologist-Ph.D.Responshie for the development of a research program utilizing in vitro and in vivo.models of inflammation and non-malignant, proliferative diseases to determine potentialstructure-activity relationships of the Company's carbohydrate compounds. This position

....reques an innovative, interactive approach to drug development.

Biochemist-Ph.D.We are seeking a Ph.D. biochemist interested in identifying the anti-inflammatory andanti-proliferative effects of novel synthetic carbohydrates in support of drug development. This position requires excellent communication skills and a great deal of scientificinitiative.

Greenwich's strong intellectual and technical resources create a challenging atmospherewhere excellence is encouraged and creativity is rewarded. Compensation is highlycompetitive and includes salary and benefits. Candidates interested in improving pat-ients lives should mail or fax resume, indicating position of interest, to: Human Re-sources Depertment, Grenwich Pharmaceutcas Inc., 501 Office Center Drive, Ft.Washingten, PA 19034. Fax: 215-540-9696. Equal Opportunity Empioyer.

GREENWICHPHARMACEUTICALSINCORPORATED

RESEARCH ASSISTANT PROFESSORPOSTDOCTORAL FELLOW

Positions available immediately in research todevelop a birth control vaccine using spermadhesion proteins or to analyze molecular mech-anisms in mammalian fertilization. Individualswith Ph.D. or M.D. and training in immunolo-gy, vaccinology, molecular biology or cell biolo-gy are encouraged to apply. Openings are in theContraceptive Development Center at the Uni-versity ofConnecticut Medical School. The Con-traceptive Center is supported by a center grantfrom NIH and by the Mellon Foundation. Ex-cellent salary and benefits commensurate withexperience.

Applications should include a cover letter,curriculum vitae, bibliography, three letters ofrecommendation and reprints of any recent pub-lications. Send applications to: Dr. Paul Prima-koff, Department of Physiology, MC-3505,University of Connecticut Medical School,Farmington, CT 06030. The University ofCon-necticut Health Center is an Affirmative Action/Equal Opportunity Employer.

0

1 mis

Synergen, Inc., is a young and rapidlygrowing research-based biopharmaceuticalcompany located in Boulder, Colorado. Weuse the latest advances in recombinantDNA technology, molecular biology andmanufacturing technology. Our focus is onthe discovery, development and productionof protein-based pharmaceuticals for treat-ment of serious human diseases.Several of our compounds have progressedthrough laboratory testing, preclinicaldevelopment and are now in human clinicaltrials. Our first commercial scale manufac-turing plant is scheduled for completionlate this year.

TOXICOLOGISTThis position will involve the use of in vivomodels to test preclinical safety of anti-inflammatory agents, cytokines, bindingproteins and neurotrophic factors. Otherresponsibilities include writing protocols formonitoring and interpreting contractedtoxicology studies along with performing inhouse GLP toxicology studies. Demon-strated experience in toxicology and physi-ology and in vivo/in vitro model experimen-tation, and a Ph. D. or DVM/Ph. D. with aminimum of 2 years Post Doc., is required.First consideration will be given to candi-dates who have experience with immunehypersensitivity reactions and the FDA drugapproval process.Boulder, Colorado residents enjoy a com-munity renowned for its beauty, culture andnatural attractions...making this a greatplace to live and work.Please send your resume to: Director ofRecruitment, Box TX,Synergen, Inc., 188533rd Street, Boulder,CO 80301. We are anEqual OpportunityEmployer. SYNERGEN

CANCER CENTER DIRECTORThe University of Vermont seeks a Director for the VermontCancer Center, an NCI-designated Comprehensive CancerCenter. Candidates with either basic science or clinical orien-tations will be considered. The Center is searching for a leaderwith a strong record of research achievement and administra-tive experience in cancer-related areas. The Director will beexpected to have a serious commitment to the development ofclinical services and the delivery of patient care; to determineprogram goals and directions for the teaching and researchthat take place under the auspices of the Cancer Center; towork with other administrative officers of the University toensure the integration and continuity of these activities; todirect the preparation of funding applications including theinstitution's Cancer Center Support Grant; and to participatewith the Cancer Center staff in programs relating to prevention,screening, and outreach to the rural Vermont population. Theexisting strengths of the Center include the Drug DevelopmentProgram, Genetic Toxicology Program, Growth Control/SignalTransduction Program, Clinical Research Program, and theCancer Control Research Program. Developing strengths in-clude the Immunobiology Program and the DNA Damage andRepair Program. The Director will hold a tenure-track academicappointment in the appropriate department of the MedicalCollege. The Director reports directly to the Dean of theMedical College and has status equal to that of DepartmentChair. UVM is an Affirmative Action/Equal Opportunity Employ-er. Applications from women and people from diverse racial,ethnic and cultural backgrounds are encouraged. Letters ofapplication should include a curriculum vitae with a summary ofrelevant research, clinical, and administrative experience, andthe names of at least three references. Applications will beaccepted until the position is filled. Please send letters ofapplication to Susan S. Wallace, Ph.D., Chairperson VCCDirector Search Committee, Department of Microbiologyand Molecular Genetics, The University of Vermont, B202Given Building, Burlington, Vermont 05477 (802) 656-2164.

Pharmaceutical/Biotechnology:Careers In Industry

This special section, reprinted from the May 8issue of SCiENCE takes an in-depth look at careers

in the pharmaceutical and biotechnology industries.--- --- --- ...1......... ...... ............ 1.... - - .... 1.1 ........... --- --- --- --- ........................... .. - - ......................................... ...............

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Also included are "career stories" from fivescientists who made the decision to moveto a position in industry.To order your copy send $3.00 plus postage to:

Postage (per copy): SdENCEUS: $1.50 Attri: Corrine HarrisIntl Surface: $2.00 1333 H Street, N.W.Intl Air: $5.00 Washington, D.C. 20005

Visa and MasterCard orders accepted by fax (202) 682-0816For information on bulk orders call (202) 326-6527

Innovative research at Sandoz has been enhancing medicine around the world for over a century. Pioneering drugs haveextended and improved the quality of life for countless individuals and revolutionized basic scientific concepts within thetransplantation and mental health fields.As a result of major expansion in basic research which will continue over the next decade, the Sandoz Research Instituteseeks highly motivated and creative Scientists. Successful applicants will become part of multidisciplinary teams ofScientists and use state-of-the-art technology to develop therapeutic agents.

BIOLOGICAL NMR SPECTROSCOPISTSWe are seeking NMR spectroscopists with training in a

biological science to make major contributions in the area ofbiomolecular structure determination using modern NMRtechniques and computer programs.

SCIENTIST B MS/BS or equivalent in Biophysics or Biochemistrywith three to five years of experience, respectively, in NMRspectroscopy. Primary responsibilities will include themaintenance and operation of NMR and computer facilities andthe development of technology in biological NMR research. Athorough background in 2-D NMR and some knowledge ofelectronics and computers is also required.Position #2219DC.ASSISTANT FELLOW Ph.D. NMR spectroscopist with 0-4 yearsof postdoctoral or industrial research experience and a strongbackground in the area of multi-dimensional NMR. Thesuccessful candidate should have proven biomolecular structuredetermination experience and have the capability to developand apply modern NMR techniques for the determination of

structures of proteins, peptides and ligand-target complexes. Theability to design and modify multi-dimensional NMR pulsesequences is highly desirable. Position #2223MS.

MOLECULAR BIOLOGISTSASSISTANT FELLOW Ph.D. in Molecular Biology with 0-4years of experience to work on projects related to peptidedisplay libraries, cell-si gnalling receptors and adhesionmolecules. The successful candidate will clone and identify novelcell surface receptors and characterize their role in signaltransduction or cell-cell interaction as they pertain toimmunoregulation and inflammation. Applicants must havedemonstrated expertise in molecular biology. Skills in tissueculture and computer analysis of DNA/proteins are desirable.Position # 1 754MS.

POSTDOCTORAL FELLOW A similar position isalso available for a Ph.D. Molecular Biologist as a

postdoctoral fellow. Our postdoctoral fellows are

eligible for a full benefits package, and our openingsare for one year but are extendible up to two years

by mutual agreement. Position #367MS.SCIENTIST B The selected individual will be involvedin the expression of cellular receptors and otherproteins involved in cell surface activation pathwaysusing both prokaryotic and eukaryotic expressionsystems.

To qualify, you must possess a BS/MS degree in a

biological science or equivalent with 3-5 years ofrelevant experience in molecular biology principlesand techniques. Demonstrated skills in DNA and RNApreparation and analysis, and an understanding or

PCR applications in molecular cloning is required.Exposure to tissue culture as well as experience incomputer analysis of DNA and proteins are desirable.Position #21 19DC.

PROTEIN BIOCHEMIST/CHEMISTPh.D. in Chemistry, Biochemistry, Cell Biology or aclosely related discipline and several years ofpostdoctoral research. Broad knowledge in proteinstructure-function relationships, secondary structuremotifs, receptor interactions, protein biochemistry,protein/peptide purification techniques and interestand experience in immunology and/or inflammationis required. The candidate must have sufficientexperience and ability to assume leadership for a

research effort on peptide libraries includingcollaboration with internal physical and analyticalchemists as well as external consultants.Position #1 752MS.

Positions at Sandoz offer personal satisfaction, professional opportunity/challenge, competitive salaries and an excellentbenefits package. Our campus-like facilities are conveniently located in northern New Jersey. For prompt, confidentialconsideration, please specify the number of the position you are responding to and forward your resume, to:

SANDOZ PHARMACEUTICALS CORPStaffing Department

Building 122/3East Hanover, New Jersey 07936-1080

An Equal Opportunity Employer M/F/H/V

A SANDOZbringing research to life

The Malaria Vaccine DevelopmentProgram (MVDP) of the Agency forInternational Devebpment is solicit-ing applications from U.S.-basedresearch institutionsdescnbing3-yearmalaria vaccine research projects.Two separate RFAs, each with a dis-tinct research focus, are being issued:RFA-R&D/H-92-001

Design & Construction ofPre-erythrocytic & Cytoad-herence Malaria Vaccines

RFA-R&D/IH-92-002Fundamental Studies inMalaria VaccineDevelopment

Proposals are due September 30,1992. The RFAs and detailed applica-tion instructions are available from:

MVDP Proect OfficerAID Office ofHealth

SA-18;Room 1232S = Washington, DC 20523

LUSw (Fax 703-875-4686)

POSITIONS OPEN

RESEARCH DIRECTOR (Ph.D. or equivalent).Tall Timbers Research, Inc., is a non-profit, scientificand educational organization, best known for its stud-ies in fire ecology and its long-term research on wildlifehabitat, resource management issues and ecology ofnatural communities. Current research includes: gamebirds, ecological forestry, and populations of nativeplants and animals. Send curriculum vitae, four refer-ences by 1 August 1992: Lane Green, Tall TimbersResearch, Inc., Route 1, Box 678, Tallahassee, FL32312-9712; telephone: 904-893-4153; FAX:904-668-7781.

SCIENCE WRITER/EDITORScience Writer/Editor for high-profile biomedical re-

search and patient care institution. Write science andmedical news and feature articles in lay language forexternal newsletter and various other institutional publi-cations, including press releases, and participate in plan-ning graphics as needed. Participate in writing text forannual report. Write brochures, reports, biographicalsketches, and other smaller publications and documentsas needed. Requirements: 3 to 5 years of experiencewriting and editing on science and medical subjects for alay audience. Journalism experience strongly preferred.Solid science background. (At least an undergraduatedegree in biology or a related subject is preferred.)Ability to produce accurate, polished copy on tightdeadlines. F eibility in receiving assignments and com-ments ofeditors and reviewers. Salary: $43,000 per year.FAX resume to: 212-639-3576.

The Fogarty International Center (FIC), NationalInstitutes of Health (NIH), Public Health Service, Be-thesda, Maryland, is recruiting for the position ofPRO-GRAM OFFICER FOR BIODIVERSITY, GS-13/14 ($46,210 to $80,087 per year depending uponqualifications). Incumbent serves as staff specialist for all

institutional and other award programs related to biodi-versity administered or supported by the Fogarty Inter-national Center. Applicants should have training andexperience in a scientific discipline related to biodiversity.For further information including qualifications require-ments, contact: Ms. Sharon Nieberding, PersonnelOfficer, FIC, at: 301-496-4625; FAX: 301-402-1135. Applications must be received by 22 June 1992.U.S. citizenship required. NIH is an Equal OpportunityEmployer.

LABORATORY MANAGER. Position is for a tal-ented research associate who is well versed in 2-D NMRand can help oversee a research group that uses a varietyof instruments for peptide purification. The successfulcandidate should have some peptide synthesis back-ground and will help to administer day-to-day operationof a laboratory of six to seven postdocs and graduatestudents involved insynthesis and biophysical studies onpeptide hormones and carbohydrates Salary $30,000 to$35,000 per year. Position available 1 A 1992.Initial appointment for 1 year. Send resume and namesand addresses ofthree references by 25 July 1992 to: Dr.Fred Naider, Department of Chemistry, The CollegeofStaten Island/CUNY, 130 Stuyvesant Place, StatenIsland, NY 10301. Applications will be reviewed untilthe position is filled. Equal Opportunity/AffirmativeActionEmployer.

POSTDOCTORAL POSMON. Available imme-diately to study the molecular biology of intermediatefilament proteins during nerve development and regen-eration in goldfish and zebrafish. A strong background inmolecular cloning is required. Please send applicationsto: Dr. Nisson Schechter, Department of Psychiatry,Health Sciences Center, T-10, SUNY at Stony BrookNY 11794. An Affirmative Action/Equal OpportunityEmployer.

POSTDOCTORAL POSMON available immedi-ately to study molecular genetics of peroxisome biogen-esis in yeast. Ph.D. in molecular/cellular biology. Inter-ested individuals send curriculum vitae and names ofthree references to: Dr. James M. Crem, De tment ofChemical and Biological Sciences, GraduateInstitute of Science and Technology, 19600 N.W. vonNeumann Drive, Beaveron, OR97 1999. Tele-phone: 503-690-1217. Equal Opportunity Employer.

POSITIONS OPEN

THE DIVISION OF BIOLOGY, CALIFORNIAINSITrUTE OF TECHNOLOGY, seeksTIO FAC-ULTY MEMBERS in the areas of cell biology andimmunology. Appointments will be for tenure-track posi-tions. Successfiul applicants are expected to generate cre-ative and productive research programs. Please send cur-riculum vitae, list of publications, a brief statement ofresearch interests and plans. The curriculum vitae shouldinclude the names and addresses ofthree references for thecandidate. Applications should be sent to: Ms. JoyceKato, Immunology and Cell Biology Search Commit-tee, Division ofBiology 147-75, California Institute ofTechnology, Pasadena, CA 91125. The Caliornia Insti-tute of Technolo is an Equal Opportunity/AflnrativeAction Employer and encourages the applications of qualifiedwomen and minorities.

DEPARTMENT OF PHARMACEUTICAL SCI-ENCES FACULTY POSITION IN DRUG DELIV-ERY FOR PROEMINS/PEPTIDES. The Colege ofPharmacy Departnent of Pharmaceutical Sciences at theUniversity of Nebraska Medical Center is seeking a facultymemberwithepertisen biological research revant to drugdelivery systems and strategies. Candidates should have aPh.D. in one of the biological or pharmaceutical scienceswith research experience in cell biology, molecular biology,or immunology related to drug delivery. The oppornityexists for the successful candidate to collaborate with amultidisciplinary faculty involved in drug delivery research toevaluate biological mechanisms related to the biopharmaceu-tics, efficacy and safety of drugs and drug delivery systems.Research in the delivery ofproteins and peptides is desirable.In addition, faculty in the Eppley Cancer Institute participatein collaborative research and the departme's graduateprogram. Applicants should submit curriculum vitae and thenames of three refeences to: Chair, Search CommitePosition #1-6143, Dqieprment of Pharmaceutical Sci-ences, Clege of Pharmacy, University of NebraskaMedical Center, 600 South 42nd Street, Omaha, NE68198-6025. Applications will be accepted until the posi-tion is filled. The University of Nebraska is an AfirmativeAcinEqua Opportunity Emplyerand encourages applatonsfrom women and minor.

POSTDOCTORAL POSMON available immedi-ately to study the organization, development, and plas-ticity of intrinsic synaptic circuits in the cerebral cortex.Opportunity for independent research in a well-equippedand funded multidisciplinary laboratory. Send curmcu-lum vitae and description of research interests and expe-rience to: Dr. Asaf Keller, Department of Anatomy,Uniformed Services University of the Health Scienc-es, 4301 Jones Bridge Road, Bethesda, MD 20814.

Equal Opportunity Employer

POSTDOCTORAL POSITION INMOLECULAR NEUROBIOLOGY

One or two NIH-funded postdocoral positions availableto carry out studies on st relations in ionchannels and recptors employing a combination of molec-ular biological, biochwmical and eectophysiological ap-proaches [seeJ. Bid. Chem. 267, 8360 (1992) for a recentpublication]. Current efforts are focused on nicotinic acetyl-choline receptors, 5HT5 receptors, and voltage-gated Cl-channels. Expeence mn moleclar biology or eectrophysiol-ogy is highfiy desirable. Please send curriculum vitae andnames of e to: Dr. Mihael M. Whit, Depart-ment of Physlogy, Medical College of Pennsylvania,3300 Henry Avenue, Philadephia, PA 19129.

SCIENCE * VOL. 256 * 5 JUNE 1992

National Institutes of HealthPublic Health Service

FELLOWSHIP INMOLECULAR

NEUROBIOLOGYThe Laboratory of Neurosciences, atthe National Institute on Aging,Bethesda, invites applicants for aFellowship position, to study molec-ular biological aspects of the brain inrelation to development and aging,neuroplasticity and Alzheimer'sdisease. The successful candidatewill be expected to apply techniquesof recombinant DNA and/or in situhybridization to address differences ingene expression in health anddisease.Applications are invited fromindividuals having a Ph.D., M.D., orcombined degrees. NIH is an equalopportunity employer and applicationsfrom women and minorities areinvited. Interested candidates shouldsubmit their Curriculum Vitae to:

Stanley I. Rapoport, M.D., ChiefLaboratory of NeurosciencesNational Institute on AgingNational Institutes of Health

Building 10, Room 6C1039000 Rockville PikeBethesda, MD 20892

More than150,000 people

paidto see your ad

in

SCIENCEClassified Advertising Department

Telephone: 202-326-6555FAX: 202-682-0816I

1478

Alkermes, Inc., a fast-growing neuropharmaceutical comparydeveloping products for the treatment of diseases of the cen-tral nervous system, is presently seeking an individual to fill thefollowing position.

NEUROPHARMACOLOGISTAlkermes is seeking a first-class neuropharmacologistspecializing in animal modelsof acute and chronic neu-rodegenerative diseases andother neurologic disorders.Projects will include eval-uating novel therapeuticagents in established animalmodels mimicking such dis-orders as Azheimer's disease,Parkinson's disease, andstroke as well as developingnew models when necessary.An important part of thejobis to select and wrk withoutside collaborators to eval-uate Alkermes therapies inspecialized models.Responsibilities will includebuilding and supervising agroup involved in in wvoresearch as well as participat-ing in project teams toaddress scientific and dinicalissues related to Alkermescompounds. The successfulcandidate will hold the fol-lowing qualifications:

O Ph.D. in neurobiology or arelated discipline with 5-10 years of post-Ph.D.experience.

El Extensive knowledge ofneuroanatomy andneurophysiology.

O At last 5 years experiencewith animal models ofchronic and acute neu-rodegenerative disordersincluding stroke.

El At least 3 years of phar-maceutical or biotechnol-ogy industry experiencestrongty preferred.

O Knowledge of models forother CNS diseases suchas brain tumor or infec-tious disease.

As an Alkermes employee,you will have the chance tomake a significant impact in astimulating environment thatfosters autonomy, responsi-bility, and innovation. Youwill also enjoy an excellentsalary and benefits package.For immediate consideration,please send your resume toAlkermes, Inc., Box CAG,64 Sidney Street, Cambridge,MA 02139.An Equal Oppoeruy Emplfer

Alkermes, Inc.

has alwaysI|ding|edgemnresearchhealthcare. Over the

m ou r-esearch havet00tify product candidates for

XMitkn and treatment of AIDS and foratment of cancer and acute inflam-

mation. We have recently begun several newresearch projects in the inflammation area,

even as we begin clinical trials on our anti-cancer compound. The year ahead promisesmany new and exciting challenges for peopleseeking a research environment that rewardsinitiative and recognizes achievement. If yourlooking for a biotech company that's goingplaces, join us today.Vice PresidentMolecular & Cell BiologyIn this highly important position, you will play a leadershiprole on IL-8 receptor antagonist and B7/CD28 immuno-regulation projects. This will involve supervising a highlyqualified professional staff of 25 and directing all aspects ofthe molecular & cell biology department including theachievement of research, budgets and staffing objectives.Additional responsibilities will require you to overseeresearch and preclinical activities for an HIV immunothera-py therapeutic project and interact with corporate partners,academic collaborators and regulatory agencies on behalf ofour research organization. The desired individual will pos-sess a working knowledge of cytokine receptors/adhesionmolecules and receptor mediated signal transduction. Yourexperience must include 8+ years' successfully managing,leading and motivating a committed research group applyingmolecular biology to problems in cell biology. PhD required.Research Scientist & ResearchAssociate - Pre-Clinical StudiesDue to the rapid progress of our lead therapeutic com-pounds, we are establishing a pre-clinical trials group forour HIV and acute inflammation projects. This group willdevelop small animal models to address tissue distribution,bioavailability and blood clearances. We are looking for aResearch Scientist with a PhD and 2+ years' experiencewith in-vivo measures of biologics and preferably somemonoclonal antibody experience. We are also looking for a

Research Associate with a BS/MS and similar experience.Repligen offers competitive salaries, equity participationincluding an E.S.O.P. and benefits such as tuition reim-bursement, three weeks' vacation and a 401(k) savings plan.Please send/FAX resume and cover letter to Ed Bocko,Repligen Corporation, One Kendall Square, Building 700,Cambridge, MA 02139, FAX # (617) 494-1786. An EqualOpportunity Employer, M/F/DIV.

RepilGen

The sixth

SANDOZ PRIZE FORGERONTOLOGICALRESEARCHworth 50,000 Swiss Francs, will be awardedby the International Association ofGerontology at the XVth InternationalCongress of Gerontology, Budapest, 4-9July 1993.Applications and nominations should besubmitted not later than15 October 1992to John L. C. Dall, MD, Official Coordinatorfor the SANDOZ PRIZE, The VictoriaInfirmary, Glasgow G42 9TY, UnitedKingdom (phone 44 41-649 4545,fax 44 41-649 2206).Information can be obtained from this officeand from any SANDOZ PHARMAcompany. (PROOF)

0-1.Embel-

/k

POSITIONS OPEN

A POSTDOCTORAL POSITION is available from1 September 1992 (negotiable) to work with Drs. BarryHalliwell and Carroll Cross, studying the mechanisms bywhich toxic gases (03, NO2, cigarette smoke) oxidativelydamage the human lung. Work will be based at Univer-sity of California Davis (UCD), but some visits to KingsCollege London to learn methods may be arranged.Applicants should have a Ph.D. in biological sciences orchemistry. Experience in HPLC, GC or MS is preferred.Apply to: Dr. Cross, Pulmonary Medicine, 4301 XStreet, UCDMC, Sacramento, CA 95817; FAX: 916-734-7924; telephone: 916-734-3564. Equal Opportu-nity Employer/Affirmative Action.

POSTDOCTORAL POSITIONS are available im-mediately to study: (1) developmental roles of DNArepair using transgenic animals with special emphasis onmouse models of human genetic diseases such as xero-derma pigmentosum and Cockayne syndrome; (2) therole ofDNA double strand breakage in homologous andnonhomologous recombination, gene amplification, andcytogenetic damage; and (3) role of extracellular matrixand matrix remodeling in regulation of tissue-specificgene expression, with an emphasis on mammary glandusing transgenic mouse models. Preference will be givento applicants with prior experience in vector designand/or transgenic animal work. Strong molecular biologybackground required. Funding available through anNIEHS training grant (U.S. citizens and permanent resi-dents only) and U.S. DOE. Send curriculum vitae andthree references to: (1) Dr. James E. Cleaver, (2) Dr.William F. Morgan, or (3) Dr. Zena Werb, Laboratoryof Radiobiology and Environmental Health, Universi-ty of Californa, San Francisco, CA 94143-0750. AnEqual Opportunity/Affinnative Action Employer.

POSTDOCTORAL POSITIONS ATOAK RIDGENATIONALLABORATORY: Four positions in murinemolecular genetics available in Biology Division (with E.Rinchik, R. Woychik, L. Stubbs, andM. Mucenski) to studygene structure and function utilizing the mouse as a modelsystem. Information/applications: Postaduae ResearchProgram/Biology,S E W

Education Divi-sion, Oak Ridge Associated Universities, P.O. Box 117,Oak Ridge, TN 37831-0117; telephone: 615-576-3456.

POSTDOCTORAL POSITION is available to in-vestigate intracellular signal transduction in platelets.Experiments will examine a cytoskeletal protein that isboth a cAMP-dependent protein kinase substrate and amember of the Ras superfamily of GTP-binding pro-teins. Recombinant DNA as well as traditional biochem-ical methods will be utilized. Send curriculum vitae andtwo letters of reference to: Nancy Andrews, Center forThrombosis and Hemostasis, CB #7015, 435 Bur-nett-Womack Building, University ofNorth Carolinaat Chapel Hill, Chapel Hill, NC 27599.

POSTDOCTORAL POSITIONSHARVARD MEDICAL SCHOOL

Using Drosophila melanogaster as a model system forstudying molecular and development aspects of cancer-related genes. Emphasis is on (1) genes involved innormal and leukemic hematopoiesis, and (2) the awdgene, the fly homolog of a human tumor metastasis-suppressing gene. Experience with molecular biologytechniques required. Send curriculum vitae and two tothree letters ofreference to: Dr. Charles Dearolf, Dana-Farber Cancer Institute, Jimmy Fund Laboratories#209, Harvard Medical School, 44 Binney Street,Boston, MA 02115. An Equal Opportunity/AffirmativeAction Employer.

A POSTDOCTORAL POSITION is available tostudy the molecular biology and physiology of the renin-angiotensin system in transgenic animals. Experience inmolecular biology or whole animal physiology is re-quired. Funding is through an Institutional TrainingGrant. Candidate must be a U.S. citizen or permanentresident. Send letter stating interest, curriculum vitae andnames of three references to: Curt D. Sigmund, Ph.D.,University of Iowa College of Medicine, B150 ORP,2501 Crosspark Road, Coralville, IA 52241. TheUniversity of Iowa is an Equal Opportunity/AffirmativeAction Employer. Women and minorities are encouraged toapply.

POSITIONS OPEN

POSTDOCTORAL POSITIONS for recentPh.D.'s to participate in an action research program onthe structure, regulation and expression of human DNArepair genes and enzymes. Current research efforts focuson the molecule defects which underlie cancer-pronehuman genetic disorders and structural analysis of mul-tifunctional repair enzymes by site-specific mutagenesis.Submit curriculum vitae and the names of three refer-ences to: Dr. Michael A. Sirover, FELS INSTITUTEFOR CANCER RESEARCH AND MOLECULARBIOLOGY, Temple University School of Medicine,3420 North Broad Street, Philadelphia, PA 19140.Equal Opportunity Employer.

POSTDOCTORAL ASSOCIATES. Molecular Bi-ologist-Somatic Cell Geneticist-Applications are invit-ed for two postdoctoral positions to work on projectsinvolving the molecular analysis of human tumors. Oneposition requires a strong background in recombinantDNA technology. Experience in chromosome walkingand in the use of cosmid or YAC libraries desirable. Thesecond position requires previous training in the use ofsomatic cell hybrids for chromosome mapping and/ormicrocell-mediated transfer. Submit curriculum vitae andnames of three references to: JT, c/o Personnel Depart-ment, Fox Chase Cancer Center, 7701 BurholmeAvenue, Philadelphia, PA 19111. We are an EqualOpportunity Employer.

I'ml"'POSTDOCTORAL POSITIONCARDIAC PHYSIOLOGY

UNIVERSITY OF MARYLANDSCHOOL OF MEDICINE

A postdoctoral position is available immediately forresearch in electrophysiology and excitation-contractioncoupling of cardiac muscle. The research will involve theuse of patch clamp techniques and fluorescent ion-

indicators, including imaging, and flash photolysis ofcaged compound in single, voltage-clamped cardiac cells.Applicants should have a Ph.D. or M.D. and experiencein electrophysiology. Interested individuals should sendcurriculum vitae and names ofthree references to: Dr. C.William Balke or Dr. Michael R. Gold, Departmentof Physiology, University of Maryland at Baltimore,660 West Redwood Street, Baltimore, MD 21201.An Equal Opportunity/Affirmative Action Employer.

POSTDOCTORAL FELLOW: CARDIOVAS-CULAR PHYSIOLOGY, TULANE UNIVERSITY.Position available for Ph.D. or M.D. with experience incardiovascular autonomic physiology to assist in thedevelopment of a research project pertaining to auto-nomic regulation of the electrophysiologic properties ofthe neonatal heart. Experience with cardiovascular re-search using animal models and physiologic monitoringsystems are essential. Experience in autonomic nervous

system physiology highly desirable. Send curriculumvitae and names of three references to: Arthur S. Pick-off, M.D., Director, Pediatric Cardiology Section,Tulane University Medical Center, 1430 Tulane Av-enue, New Orleans, LA 70112.

POSTDOCTORAL RESEARCH FELLOW-SHIP, DEPARTMENT OF PATHOLOGY. The De-partment of Pathology at Fox Chase Cancer Center seeksapplicants for a fellowship in surgical oncologic pathol-ogy and research in the area of molecular biologyin tumor diagnosis. Applications for training fellowshipsfor 1993-94 are open to pathologists wishing to betrained in those aspects of cancer diagnosis research. Theposition entails engagement of 50% of the time inresearch and 50% in surgical pathology of tumor diag-nosis. Fellowships are awarded for 1 year and are subjectto second-year renewal. Fellows will, in general, beselected from applicants with some postdoctoral researchexperience related to cancer or surgical pathology. Dead-line for applications is 1 December 1992. For additionalinformation, contact: Jeanne Nace, Administrative As-sistant, Department of Pathology, Fox Chase CancerCenter. Applications should be submitted to: JoseRusso, M.D., Chairman, Selection Committee forPostdoctoral Fellowship, Department of Pathology,Fox Chase Cancer Center, 7701 Burholme Avenue,Philadelphia, PA 19111. Attention: Personnel De-partment. We are an Equal Opportunity/AfirmativeActionEmployer.

SCIENCE * VOL. 256 * 5 JUNE 1992

A UNIVERSITY OF KENTUCKYCOLLEGE OF MEDICINE

CANCER CENTER DIRECTORThe University of Kentucky has reactivated thesearch for a new Director of its Markey CancerCenter. The Center has over 168,000 squarefeet of space, 56 inpatient beds, induding a 12bed bone marrow transplant unit, approximate-Iy 30,000 squarefeetof research space and anexcess of 7,000 square feet of clinic space.More than 140 faculty in 25 departments of 8different colleges of the University participate inCancer Center programs. A variety of multidis-ciplinary research programs are served byeight core facilities: macromolecular structure,flow cytometry, transgenic mouse production,electron misroscopy, magnetic resonance im-aging, pathogen-free animal care, clinical re-search and biostatistics. The Center is a majorparticipant in the Southwest Oncology Group,the National Surgical Adjuvant Breast andBowel Project and the Children's Cancer StudyGroup. Notable strengths include molecularbiology, tumor immunology, gynecologic oncol-ogy, neuro-oncology, bone marrow transplan-tation, and drug formulation and testing.Candidates with either basic science or clinicalorientations will be considered. Essential qual-ifications are a strong record of researchachievement and knowledge of administrativeand clinic functions in cancer-related areas.Letters of application should include curriculumvitae and the names of at least three refer-ences. Minorities and females are encouragedto apply. Consideration of applications will be-gin June 5, 1992.Please send letters of application to:Edythe Tevelson LachSpecial Assistant to the DeanCollege of MedicineRoom MN 149AChandler Medical CenterLexington, KY 40536-0084The University of Kentucky Is an Affirmative

Action, Equal Opportunity Employer

POSTDOCTORAL FELLOWGENE EXPRESSIONDEC Pharmaceuticals Corporation has

I gathered a dedicated scientific and admnrs-*trtive team focused on achieving ourc eu mision of developing antibody-based therapeuticaWe seek a RPstdoctoal Fellow to join ourgrowing team. This position will focus onexpression of polymeric immnogobulin inmammalian cells and the use of homologousrecombiation for expression of inmuno-glbulin by mammalian cell The duties willinclude performing corpixmxca biologytehniqus and s~ile tissue culture as wel as

developing. ectn, and evahluting cmlexperiments. The selected candidate willhave a PhD or its equvalnt in MolecularBiology, Genetics, or a related field.IDEC Pharmaceuticals is a leader in thedevelopment of immunologically activemn onal antibodies for therapeutic appli-cations in the area of certain cancers. HIVinfection, and autoimmune disorders. Wepride ourselves in the excellence of ourteam members and invite you to join us.We offer a competitive compensationpackage and excellent working conditions.For consideration, ploase send your resumeand references to: IDEC PharmaceuticalsCorp., Ad SPD, 11099 N. Torrey Pines Rd.,Suite 160. La Jolla, CA 92037. EWE.

PHARMACEUTICALSCORPORATION

Public Authority for AppliedEducation and Training

State of Kuwait

The Public Authority for Applied Education andTraining invites applications for faculty positionsfor the 1991-92 academic year in the ranks andspecializations indicated below:

-Professor, Associate Professor and AssistantProfessor (earned Ph.D. in areas of specializa-tion required)-Lecturer, Teacher, Assistant Teacher (mini-mum Master's degree in areas of specializationrequired)

The positions are tenable at the College of BasicEducation, a two-year post-secondary college inKuwait.

Areas of Specialization:

BotanyBio ChemistryGeologyDevelopmental PsychologyEvaluation and MeasurementComputers in EducationPhysical EducationHome EconomicsDesign & Production of Educational

MaterialsArt Education (wood work, metal work,

framing and painting, design, needle work)PhysicsZoologyMath (math analysis, teaching methods,

algebra, geometry)Library & Information ScienceEducational TelevisionMusic EducationInterior DesignComputer ScienceTeaching Methodology (lesson planning,

practicum in early childhoodeducation)

Qualified applicants should write for applications,salary scale and conditions of service to:

PAAETCultural DivisionKuwait Embassy3500 International Dr., N.W.Washington, D.C. 20008Tel: 202-364-2100

Completed applications should be returned to theabove address and must include curriculum vitae,and official academic transcripts. Applications willbe forwarded for action to the Public Authority inKuwait.

NOTE: Documents submitted will not be returned.

POSTDOCTORALPOSITION

IN MR RESEARCHThe Laboratory of Cardiac Energetics, National Heart,Lung and Blood Institute, NIH, Bethesda, Marylandinvites applications from qualified individuals for apostdoctoral staff position in a group developingmagnetic resonance imaging and spectroscopy usinga whole-body 4 T magnet.The ideal candidate must have a Ph.D. in physics,computer engineering or electrical/electronicengineering, with a strong interest in in vivo NMR,and a good track record for application of hardwareinnovation. This research program is currentlymaking rapid progress in high field MR spectroscopyin volunteers and patients, and in functional brainmapping using gradient echo MRI.

Applicants should send curriculum vitae, a briefdescription of research experience and interests, andnames and addresses of three references to:

Dr. Robert TurnerNational Institutes of HealthNational Heart, Lung & Blood Institute c3 HiLaboratory of Cardiac EnergeticsBuilding 10, Room B1D1619000 Rockville PikeBethesda, Maryland 20892

U.S. Citizenship is RequiredNIH is an Equal Opportunity Employer

~WashingtonWASHINGTON*UNIVERSITY-IN.ST*LOUIS

TENURE TRACK ASSISTANT PROFESSORMOLECULAR BIOLOGY AND PHARMACOLOGY

The Department of Molecular Biology and Pharmacolo-gy at Washington University School of Medicine isrecruiting an individual at the level of Assistant Profes-sor in the tenure track. Outstanding scientists workingwithin the broad area of molecular biology and biologicalchemistry will be considered with an emphasis on thosewho are expert at using molecular genetic approachesto examine fundamental questions in gene regulationand function, particularly as they affect cellular differen-tiation.

Interested applicants should forward a curriculum vitae,a short summary of research plans, and the names andaddresses of three references to:

Search Committee (c/o Jeffrey Gordon, Head)Department of Molecular Biology and Pharmacology

Washington University School of Medicine660 South Euclid Avenue, Box 8103

St. Louis, Missouri 63110

Washington University is an Affirmative Action/EqualOpportunity Employer committed to increasing the rep-resentation of women and minority groups on its faculty.

ScientistLarge-Scale Cell CultureProcess Development

Genentech, Inc., currently has an opportunity foran experienced Scientist. Working closely withother scientists, you will develop and scale-up cellculture processes for the production of recombi-nant proteins for clinical applications. Additionally,you will improve upon current state-of-the-art forbioreactor design and process control, cell/liquidseparation and continuous culture. You will alsowork with various departments to specify processparameters as well as monitor and review earlyclinical production runs.

Requirements include an MS/PhD in ChemicalEngineering, or related field, and hands-onexperience in small- and large-scale cell culture.Strong leadership and communication skills areessential Industrial experience is preferred.We offer an excellent salary and benefits package.For immediate consideration, please send yourresume to Genentech, Inc., Human Resources,Dept LPG, 460 Point San Bruno Blvd., South SanFrancisco, CA 94080. We actively support andpromote affirmative action and equal opportunityemployment. Women and minorities are encour-aged to apply.

Genentech, Inc.

VACANCYANNOUNCEMENT FORSCIENTISTS/SENIOR SCIENTISTS

The International Centre for Research in Agroforestry (ICRAF) is an autono-mous, non-profit organization, established in 1977 with headquarters in Nairobi,

CR AF^ = Kenya and a member of the Consultative Group on International Agricultural*EUCFRAF Research (CGIAR) ICRAF's overall goal isto mitigate tropical deforestation, landdepletion and rural poverty through improved agroforestry systems.

AGROFORESTRY (BRAZIL)The individual will be stationed at EMBRAPA's Agroforestry Research Centre in Porto Velho, Rondonia,Brazil, as part of a team with Brazilian scientists and members of the CIAT-IICA-CATIE consortium onnatural resource management. Main responsibilities consist of conducting strategic research on nutrientcycling and soil fertility improvement in promising agroforestry alternatives to slash and bum andrecuperation of abandoned lands. Work will be done in collaboration with a multidisciplinary team, bothon-station and on-farm. The scientist will also collaborate in evaluating multipurpose trees, trainingactivities and in strengthening national institutions.Candidates must have a Ph.D. degree or equivalent in agronomy, soil science, horticulture or forestrywith special emphasis on soil fertility/nutrient cycling. Other requirements broad experience in tropicalannual and/or perennial crops and/or pastures, experimental methods, and at least 5 years experiencein intemationally recognized research; demonstrated ability to design, formulate and coordinate researchprograms with minimal supervision; computer literacy and understanding of cross-cultural multidis-ciplinary environments. Fluency in English and Spanish or Portuguese is essential. Spanish speakingcandidates will be expected to develop proficiency in Portuguese.MULTI-PURPOSE TREE IMPROVEMENT (BRAZIL)The individual will be stationed at EMBRAPA's Agroforestry Research Centre in Manaus, Brazil, and willwork as part of a team with Brazilian scientists and members of the CATIE-CIAT-IICA consortium onnatural resource management. Main responsibilities are: to collect, select and improve multipurpose treegermplasm of importance to provide agroforestry alternatives to slash and bum agriculture withemphasis on indigenous species, such as Bractis gasipaes; evaluating adaptability to acid soils,participate in training programs and strengthen national institutions. The individual will also be expectedto develop a collaborative multi-locational programme of species/provenance evaluation.Candidates must have a Ph.D. degree or equivalent in breeding in forestry, annual crops or horticulture;and at least 5 years experience in intemationally recognized research; demonstrated ability to design,formulate and coordinate research programs with minimal supervision; computer literacy and under-standing of cross-cultural multidisciplinary environments. Fluency in English and Spanish or Portugueseis essential. Spanish speaking candidates will be expected to develop proficiency in Portuguese.CONDMONS OF EMPLOYMENTAppointments to these international senior staff positions will be for two years beginning in July 1992 orsoon thereafter. Competitive salary and benefits are comparable to similar international agriculturalresearch institutions. Applicants should send their updated C.V., including salary details, names and fulladdresses (including telephone, fax/telex) of three referees so as to arrive not later than 15 June 1992addressed to the Head of Human Resources, Intemational Centre for Research in Agroforestry, P.O.Box 30677, Nairobi, Kenya, Tel: (254-2) 521450; Telex: 22038; E. Mail: CG1354, Telefax: (254-2)521001; Cable: ICRAF.

ICRAF IS AN EQUAL OPPORTUNITY EMPLOYER

Cell BiologistScale-Up Group

Genetic Therapy, Inc., a leadingbiotechnology company, is workingwith researchers at the NationalInstitutes of Health and academicmedical centers to develop retroviralmediated and other gene transfertechnologies applicable to human genetherapy. The Scale-up group iscurrently seeking a scientist with aPh.D. in cell biology or related fieldsand at least two years of postdoctoralexperience in mammalian cell cultures.The candidate will develop scale-upcell culture techniques for viral vectors.Experience and familiarity with largescale cell cultures is helpful. GTIoffers a stimulating and challengingresearch environment with competitivesalaries and benefits. Please send aresume along with the names andaddresses of two references to:

* Genetic Therapy, Inc.Human Resources - SUI

! 19 Firstfield RoadGaithersburg, MD 20878

GTI is an equal opportunityemployer.

SAVE 25%Running your recruitment advertisement once

may not be enough. Place the same ad againwithin the next four issues and we will give you25% off your second insertion.

* Get more attention* Get more value* Get more applicantsReach the global scientific community you needto maximize your recruitment efforts. Sciencedoes it bigger and better and now Science does itat greater savings for you.

Call, write, or fax:

Science Classified Advertising1333 H Street, N.W.

Washington, D.C. 20005Phone: 202-326-6541/6555

Fax: 202-682-0816

ICOS Corporation is a biotechnology company pioneering scientific develop-ment in the fields of cell trafficking and cell activation. Positions are availablefor scientists with postdoctoral experience in the following areas:

ANTIBODY ENGINEERINGMolecular Biologist with experience in the engineering and humaniza-tion of monoclonal antibodies.

CADHERINSCell Biologist/Protein Biochemist/Molecular Biologist with experiencein the biology of cadherins or other junctional molecules.

SIGNAL TRANSDUCTIONMolecular Biologist with experience in receptors, G proteins, andprotein kinase signalling mechanisms with special emphasis on struc-

tural definition of protein-protein interactions.

ICOS offers a stimulating intellectual environment and a state-of-the-artresearch facility. Our compensation package includes a competitive salaryand a comprehensive benefit program which includes stock options.

Please send your C.V. to:

Human Resource DirctrICOS Corporation22021 20th Avenue S.E.BothelL WA 98021FAX: (206) 485-1911

ICOS is an Equal Opportunity Employer.No Phone Calls Please.

AN__).- -----

ANNOUNCINGANEWSERVICEFROM

SCIENCE

Now you can pay for your lineclassified ad with a credit card -we accept MasterCard and VISA.

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advantage of this service, or askus for further details.

SCIENCE Classified AdvertisingTel: 202-326-6555FAX: 202-682-0816

Recruitment Ad forUniversity of California

Institute on Global Conflict and Cooperation

The University of California Institute on Global Conflict and Cooperation (IGCC) invites applications

for two positions as Coordinator of Policy Research; one to begin September, 1992, the second to

begin at a date to be arranged during the 1992/93 academic year.

IGCC is a systemwide research unit of the University of California, headquartered on the U.C. SanDiego campus. It was established to conduct and encourage research and instructional programs inthe causes of international conflict and the opportunities for international cooperation.

The Coordinators of Policy Research report to the Director of IGCC and are responsible for assistingin the organization and conduct of IGCC policy-related projects-for example, on conventional arms

control, nuclear proliferation and nuclear arms control, Asian security relations, international environ-mental policy, and economic competitiveness and national security. The main responsibilities of thepersons occupying these positions are to provide an effective link between scholarship in internationalaffairs conducted in the UC system and the world of foreign policymaking in the United States andabroad. The Coordinators of Policy Research at one and the same time must possess scholarlycredentials and enjoy the respect of academics, while being conversant with the major foreign policyissues of the day and having demonstrated experience in the foreign policymaking process. Amongthe specific tasks of the Coordinators of Policy Research are organizing international conferencesaddressing major foreign policy issues, preparing discussion papers for these, disseminating thefindings of IGCC policy-relevant studies as widely as possible, working with research directors anddevelopment personnel on fundraising, and supervising postdoctoral fellows in related researchfields. Teaching one class a year is possible.

IGCC seeks candidates who have a Ph.D. in international relations, political science, or naturalscience, experience in the policy world, and a demonstrated capacity to contribute effectively to theIGCC policy studies program.

Salary and rank commensurate with qualifications and based on UC payscale. Send vitae, names offive references, samples of written work and any other relevant materials indicating professionalaccomplishments directly to the following address: University of California, San Diego, PolicyResearch Search Committee, (SCI) Institute on Global Conflict and Cooperation (0518), 9500 GilmanDrive, La Jolla, CA 92093-0518. All applications received by August 1, 1992 or thereafter untilpositions are filled will receive thorough consideration. UC is an AA/EO employer.

Research ScientistImmunology

Genetic Therapy, Inc., a leadingbiotechnology company, is workingwith researchers at the NationalInstitutes of Health and academicmedical centers to develop retroviralmediated and other gene transfertechnologies applicable to human genetherapy. The ImmunologyDepartment's Cancer Gene TherapyProgram is currently seeking scientistsspecializing in tumor immunology,tumor cell biology and development ofin vivo tumor models. This positionrequires a Ph.D. and at least four yearspostgraduate experience. GTI offers astimulating and challenging researchenvironment with competitive salariesand benefits. Please send a resumealong with the names and addresses oftwo references to:

Genetic Therapy, Inc.Human Resources -

CGT-RS1' 19 Firstfield Road

Gaithersburg, MD 20878

GTI is an equal opportunityemployer.

POSITIONS OPEN

ALFRED P. SLOAN FOUNDATIONPOSTDOCTORAL FELLOWSHIPS IN MO-

LECULAR STUDIES OF EVOLUTION. Up to tenawards. Total compensation: $25,000 plus $10,000 re-search funds per year. Tenable for 1 to 2 years atuniversities or non-profit research institutions in theUnited States or Canada. Applicant should be prospec-tive or recent Ph.D. in molecular biology, evolutionarybiology, or related discipline. Deadline: 4 September1992. For details, contact: Dr. Michael S. Teitelbaum,Alfred P. Sloan Foundation, 630 Fifth Avenue, NewYork, NY 10111. Telephone: 212-649-1649.

CELLULAR AND MOLECULARHEMATOPOIESIS

RESEARCH INVESTIGATOR to join groupstudying stem cell regulation, with projects including:(1) novel stem cell cytokine receptor genes; (2) stromalcell cytokine production and regulation; (3) T cell path-way-specific cytokine induction; and (4) hematopoiesisfollowing bone marrow transplantation. Applicantshould have demonstrated experience in mammalian cellculture and molecular biology. Appointment to be at thelevel of POSTDOCTORAL FELLOW or ASSIS-TANT RESEARCH SCIENTIST, depending uponqualifications. Applications, including three references,should be sent to: Stephen G. Emerson, M.D., Ph.D.,Cell and Molecular Biology Program & Departmentof Internal Medicine, University of Michigan, Room5510B MSRBI, 1150 West Medical Center Drive,Ann Arbor, MI 48104. An Equal Opportunity/Affirma-tive Action Employer.

TEACHING FELLOWSHIP, COLLIN COUN-TY COMMUNITY COLLEGE (CCCC). Requiresmaster's degree with a major and/or 18 graduate semesterhours in the teaching discipline from a regionally accred-ited institution and a MINIMUM of NO college levelteaching experience to a MAXIMUM of no more than 3years of full-time equivalent college teaching. Salary:$25,000 plus benefits. Call: 214-881-5666 for moreinformation and to request an application. Ethnic minor-ities and persons with disabilities are encouraged to apply.CCCC does not discriminate on the basis of race, color,religion, sex, national origin, age, disability or veteran status.

POSTDOCTORAL FELLOW/RESEARCH AS-SISTANT. Two positions to study the structure/func-tion of the yeast mitochondrial ATP synthase and theevolution of enzyme specificity in isocitrate dehydroge-nase. Experence in molecular biology, genetics or pro-tein biochemistry desirable. Competitive salary and ben-efits. Send curriculum vitae and names of three refereesto: Tony Dean, Biochemistry, UHS/CMS, 3333Green Bay Road, North Chicago, IL 60064-3095.UHS/CMS is an Equal Opportunity Employer.

POSTDOCTORAL RESEARCH FELLOW towork on characterizing genes acting to control theexpression of murine T-lymphocyte differentiation anti-gens. Project involves determining the molecular basis ofmutant somatic cell lines showing altered expression ofthe CD8 or Thy-1 cell surface glycoproteins. Possibleapproaches include genomic sequencing, in vitro, and invivo footprinting, or the construction ofcDNA librariesand the use of subtractive hybridization. An opportunityfor someone to work relatively independently in anexcellent research environment. Requires a Ph.D. inmolecular biology or a related field and an interest inbasic immunology or cellular differentiation. Send cur-riculum vitae to: The Salk Institute, Department BH,P.O. Box 85800, San Diego, CA 92186-5800. EqualOpportunity Employer.

POSTDOCTORAL RESEARCH ASSOCIATEto study the regulation of expression and function of a7integrin (JCB 117, 643) during the development of theskeletal myogenic lineage using monoclonal antibodiesand recombinant DNA. A limited amount of teachingwill include delivery of immunology laboratories tofirst-year medical students. Experience in molecular biol-ogy and immunology preferred. Potential for annualreappintment; to start 20 August 1992, or thereafter.Send curriculum vitae and names of three references to:Stephen J. Kaufman, Ph.D., University of Illinois,Department of Cell & Structural Biology, 506 Mor-rill Hall, 505 South Goodwin, Urbana, IL 61801.The University ofIllinois is an Equal Opportunity/Affirma-tive Action Employer.

POSITIONS OPEN

POSTDOCTORAL RESEARCH ASSOCIATEMOLECULAR GENETICS

Position available 1 July 1992 to study DNA rear-rangement in the ciliate Tetrahymena. Experience inrecombinant DNA technology and/or DNA sequenceanalysis is required. Send curriculum vitae and names andtelephone numbers of three references to: Dr. KathleenKarrer, Biology Department, Marquette University,Milwaukee, WI 53233. Equal Employment Opportunity!Affirmative Action Employer.

POSTDOCTORAL RESEARCH POSITIONnow available for studies of growth factor regulation ofcancer cell proliferation. Opportunity to participate incollaborative research within the Division of Reproduc-tive Endocrinology. Experience in cell and molecularbiology is required. Send curriculum vitae, statement ofinterests, and names of three references to: Sydney A.Shain, Ph.D., Professor, Department of Obstetricsand Gynecology, University of Texas Health ScienceCenter, 7703 Floyd Curl Drive, San Antonio, TX78284-7836. An Affirmative Action/Equal OpportunityEmployer.

RESEARCH ASSOCIATE POSITIONSDEPARTMENT OF CROPAND SOIL SCIENCES

Two POSTDOCTORAL RESEARCH ASSOCI-ATE positions available immediately. (1) To constructplant expression vectors by in vitro mutagenesis. Musthave experience in gene cloning using plasmid vectorsand in oligonucleotide-directed mutagenesis. (2) Geneticengineering of potatoes or maize. Both positions annu-ally appointed, renewable up to 3 years based on fund-ing. Send curriculum vitae, transcripts and three letters ofrecommendation to: Dr. M. Sticklen, 202 PesticideResearch Center, Michigan State University, EastLansing, MI 48824; FAX: 517-353-5598.

PHYSICIST (POSTDOCTORAL RESEARCHASSOCIATE): Job Site: Troy, New York. Study dy-namic scaling in epitaxial growth using HRLEED, STMand other interfacial characterization techniques. RequirePh.D. in physics; 2 years of experience in job offered or2 years of experience as physics research assistant inexperimental surface and interfacial physics, includingcharacterization techniques; knowledge of electron dif-fraction theory and thin film growth demonstrated bythesis or published papers; proficient with HRLEED,STM. Salary: $25,650. Send resume, in duplicate, twoprofessional references to: C. Hartman, NYS Depart-ment of Labor, 100 Broad Street, Glens Falls, NY12801. Refer to: J.O. #NY0001266. DOT CODE023-061-014.

RESEARCH ASSOCIATEMOLECULAR BIOLOGY

Applications are invited for a research position availableimmediately in a small, independent, privately endowedlaboratory newly organized for research in the molecularbiology of human diseases, with emphasis on the develop-ment of novel diagnostic tests for diseases and diseaseagents. Experience in biochemistry and molecular geneticsor cell biology required. Familiarity with monoclonalantibody techniques and molecular cloning useful; butdemonstrated scientific originality and imagination moreimportant than area of spialized expertise. Apply bymailing resume and a brief statement of research interestsand accomplishments to: EPG Laboratories, 111 EastShore Road, Manhasset, Long Island, NY 11030.

RESEARCH ASSOCIATEThe Department of Biochemistry and Cell Biology

announces the availability of a research associate positionin the areas of metalloprotein structure and function.Previous experience in one of the following areas ishighly desirable: purification and/or characterization ofmembrane-bound enzymes, electron transport proteins,biophysical technique (especially epr). Please include thenames of three individuals who are willing to providereferences on behalf of the applicant.

All information should be sent immediately to: G.Palmer, Department ofBiochemistry and Cell Biolo-gy, Rice University, P.O. Box 1892, Houston, TX77251. Rice University is an Equal Opportunity Employer.

POSITIONS OPEN

RESEARCH ASSOCIATE (LAB TECH. III) ForNIH-funded study of heat shock protein 27 in breastcancer. Duties include performing routine molecularbiology techniques and ordering supplies. Minimumqualification 1 year of experience with molecular biologytechniques plus a B.S. degree, $22,484 per year. Forwardresume and list of references to: Dr. Steve Carper,Chemistry Department, University of Nevada, LasVegas, Las Vegas, NV 89154, FAX: 702-597-4159.Affirmative Action/Equal Opportunity Employer.

RESEARCH ASSOCIATE position available imme-diately to study molecular aspects of growth factors,receptors, and signal transduction in normal and malig-nant hemopoietic cells. Ph.D., M.D., or equivalent and 2years of postdoctoral experience in hemopoiesis andmolecular biology research required. Send curriculumvitae and references by 26 June 1992 to: Dr. K S.Zuckerman, University of Alabama at Birminham513 Tinsley Harrison Tower, Birmingham, AL 35294.An Equal Opportunity/Affirmative Action Employer.

RESEARCH AFFILIATE for an NIH-funded re-search project. Cytokines in inflammatory diseases will beinvestigated at the cell level with special emphasis onultrastructural and functional characterization. Candi-dates should have a Ph.D. degree with experience andinterest in protein biochemistry and molecular biology,tissue culture, immunochemistry and electron microsco-py. Submit curriculum vitae and the names and addressesof three references: Dr. Steven A. Rich, Health Re-search, Inc., Wadsworth Center for Laboratories andResearch, New York State Department of Health,Empire State Plaza, P.O. Box 509, Albany, NY12201-0509.

ASSOCIATE SPECIALIST in molecular and cellbiology, Division of Biochemistry and Molecular Biolo-gy. We are able to support an individual ($38,448 to$46,296 per year) to do research in genetic toxicology,cellular oxidative damage, aging, and carcinogenesis.Supervise analytical facility of computer-controlledHPLC's (with electrochemical, chemiluminescence andUV-diode array detection), and capillary GC (with CI-MS, NP and EC detection). Candidates need a Ph.D.degree in pharmacology or related field and demonstrat-ed productivity in analytical chemistry (knowledge ofcomputers), DNA adducts, cellular oxidative damage,aging, and carcinogenesis. Experience in the handling ofanimals is required.

Qualified candidates should send a letter of application,resume, names of three references, and copies of relevantpublications to: Dr. BuceN. Ames, Division ofBiochem-

ry andMolecular Biology, 401 Barker Hall, Universityof Califbrnia (UC), Berkeley, CA 94720. Deadline forreceipt ofapplications is Friday 3 July 1992 or 30 days frompublication date, whichever is later. UC Berkeley is an EqualOpportunity Affirmative/Action Employer.

COMMONWEALTH OF PENNSYLVANIAENVIRONMENTAL ECONOMIST

SALARY RANGE: $39,511 TO $61,066The Pennsylvania Department of Environmental Re-

sources has an opening for an economist specializing ineither ecological or engineering economics or both. Theposition will focus on economic aspects of protectingpublic health and the environment and may, dependingon the applicants qualifications, include natural resourcevaluation/cost recovery, cost-risk-benefit issues in thechoice of remedial alternatives and evaluation of engi-neering effectiveness, impacts of permitting on highvalue natural resources, and costs of policy implementa-tion versus health and other costs ofnot implementing. Itwill involve development and review activities, expertwitnessing and staf training. Strong writing and com-munication skills and a doctorate in one or more of theabove disciplines is required. This position is located inHarrisburg, Pennsylvania. Send resumes with copy ofthis ad to: The Pennsylvania Department of Environ-mental Resources, Bureau of Personnel (EE), Room717, Executive House, P.O. Box 2357, Harrisburg,PA 17120. For further information, call Linda Waldeat: 717-783-2021.The Department is an Equal Employment Opportunity/

Affirmative Action Employer.

SCIENCE * VOL. 256 * 5 JUNE 19921484

HELPING OTHERS LIVEA BETTER LIFEBoehringer Mannheim Corporation is a rapidly growing leader in the field ofMedical

Diagnostics and Medical Research. This leadership has been attained through .:::::::.:.:..:::I

emphasis on quality and team effort Due to our growth, we are currently seeking a .........Bone Research and Product Development professional

The incumbent will participate in biochemical, functional, histochemical, ultrastruc-tural and cytochemical studies and product development as part ofan interdiscipli- . ......

nary team. Studies will focus on enhancement of biologic and mechanicalperfor-mance ofimplantable orthopedic devices using novel biological and molecular ......

approaches.

We are seeking a candidate with a Ph.D. (or equivalent degree) with a strong

background in biochemistry and experience in biochemistry/biologyspecificallyrelated to bone. A minimum of2 years ofpostdoctoral experience preferred anddemonstrated competency in the bone area is required. A background in growth

factors or in vivO/n vitro osteo-cell responses to various stimuli is desirable. Needhighlymotivated individual who will take a leadership role in many levels

ofproduct R&D.

At Boehringer Mannheim, we offer an exciting and challenging work environment, an

excellent compensation and benefitprogram including a 401(K), as well as relocationassistance. Please send resume including salary history to: Dept TW,

Boehringer Mannheim, Human Resources, RP. Box 50100, 9115 Hague Road,Indianapolis, IN 46250. An Equal Opportunity Employer. Axed

BOEHRINGERMANNHEIMCORPORATION

Science Innovations21 to 25 July 1992, San Francisco

Issue date: 17 July 1992

Electron Microscopy Society of An17 to 20 August 1992, Boston

Zulus. dntt - 21 x1lV 1 092

1 _ _ _ _ _ _ _ __ _ _ _

DEANCOLLEGE OF ARTS AND SCIENCE

VANDERBILT UNIVERSITYVanderbilt University invites applications and nominations for the posi-tion of Dean, College of Arts and Science.

The Dean bears chief responsibility for the academic, fiscal, and admin-istrative leadership of the College of Arts and Science and reports directlyto the Provost. We seek a distinguished scholar with outstanding abilitiesin leadership and administration, who is capable of fostering high qualityresearch and teaching. Candidates must qualify for appointment to therank of Full Professor with tenure in a department of the College.

Vanderbilt University, an independent, private institution founded in 1873,has approximately 9,000 students and 1,400 full-time faculty members on

a single campus. Its schools include the College of Arts and Science, theGraduate School, Blair School of Music, Owen Graduate School ofManagement, Peabody College, and the schools of Engineering, Law,Medicine, and Nursing.The College of Arts and Science, with approximately 3,400 undergraduateand 600 graduate students, occupies a central position within the Univer-sity. Its more than 300 full-time faculty members, in 22 Departments and12 Programs, pursue a broad range of activities in teaching and research.

Vanderbilt University is committed to the principles of diversity andaffirmative action. It strongly encourages nominations of, and applicationby, minority and female candidates. Vanderbilt is an Affirmative Action,Equal Opportunity Employer.Applications should include a letter of interest, a curriculum vitae and thenames, addresses, and telephone numbers of at least four references.Nominations should be made by letter. Please send these materials to:

Professor Randolph Blake, ChairCollege Deanship Search CommitteeOffice of the Provost221 Kirkland HallVanderblft UniversityNashville, Tennessee 37240

FAX: 615-322-7629The Search Committee will begin reviewing applications immediately and

continue until the position is filled.

U.S Public Health ServiceEPIDEMIOLOGY

TRAINING PROGRAMApplications are currently being accepted for the 1993 U.S. PublicHealth Service (PHS) Epidemiology Training Program.APPLICATIONS ARE DUE SEPTEMBER 14,1992. Training beginsapproximately July 1, 1993.Features: The first year, trainees attend a university to studyepidemiology, biostatistics, and related subjects. The subsequent twoyears, they work with senior epidemiologists for one of the followingagencies: National Institutes of Health, Food and Drug Administration,National Center for Health Statistics, or Alcohol, Drug Abuse, andMental Health Administration. Individuals who have a year of training inepidemiology may be accepted for the final two years of the program.

Compensation depends on the chosen personnel system. The twomost common are:

1. A limited appintment in the Commissioned Corps of the USPHSin which the usual rank for program entrants will be Lieutenant (0-3).The starting salary for an 0-3 physician with dependents is about$42,300 depending on training and experience. For non-physicians ofthe same rank with dependents, the starting salary is about $37,300.Approximately 37% of these salaries is exempt from federal, state, andlocal income tax.

2. Appointment as a staff fellow in the sponsoring agency withstarting salaries of approximately $42,500 for physicians and $28,000for non-physicians. An increase of up to $2,000 per year will take effectin the second and third years.Eligibility: M.D., D.O., Doctorate or Ph.D. in a health discipline, andone year of postdoctoral training/experience by July 1, 1993; U.S.citizenship by September 14, 1992; acceptability to aM H. program,or more advanced public health degree for the first year.To obtain an application, send your name and address to: NIHTraining Center, Epidemiology Training Program, EPS/100,9000 Rockville Pike, Bethesda, MD 20892, or call 301/402-3402.

The PHS Epidemiology Training Program is an equal opportunity employer.

m

POSITIONS OPEN

LEAD CYTOMETRY TECHNOLOGISTChildren's Hospital, Boston, is seeking a full-time

LEAD CYTOMETRYTECHNOLOGIST in our Ge-netics Department. Responsibilities include preparingand operating machines for cell sorting experiments.Requires experience with flow cytometry and computers.Please send resumes to: Doreen McGaff, Human Re-sources, Children's Hospital, 300 Longwood Avenue,Boston, MA 02115. Equal Opportunity Employer.

ASSOCIATE RESEARCH SCIENTISTTo join ongoing research on water movements across

ocular epithelia and other cells. Some work involvesculturing cells and assaying osmotic and diffusional waterpermeabilities of cells and subcellular elements. Otherwork involves biochemical and molecular biological tech-niques to study membrane proteins. Cell volumes aremeasured with optical techniques. Expertise required incell culture, biochemistry, physical optics, mathematicaland numerical methods, computer operations and inter-faces, electronics, programming, etc. Ph.D. or M.D.Salary: $30,000 per year. Start: 1 July 1992. Sendcurriculum vitae to: Dr. Jorge Fischbarg, Departmentof Ophthalmology, College of Physicians and Sur-geons, Columbia University, 630 West 168th Street,New York, NY 10032. Columbia University is an EqualOpportunity/Affirmative Action Employer.

NATURAL PRODUCTS CHEMIST. CampbellResearch and Development, a division of the CampbellSoup Company, in Davis, California, is seeking a naturalproducts chemist. The successful candidate must be ableto independently develop methods for the isolation,identification and further analysis of plant metabolitesusing GC, HPLC and other appropriate methods.Knowledge of plant metabolites ("phytochemicals") asrelated to human nutrition is desirable. Must have excel-lent communication skills. Requires Ph.D. or M.S. innutrition, biochemistry, chemistry or other areas relatingto human health and plant metabolites. Starting date: 1August 1992. Facility located 6 miles from the Universityof California, Davis, campus. Submit resume, transcriptsand names ofreferences to: Ms. Dawn Adams, CampbellResearch and Development, 28605 County Road 104,Davis, CA 95616. Telephone: 916-753-2116.

MOLECULAR AND CELLULARNEUROBIOLOGISTS

MONTREAL NEUROLOGICAL INSTITUTEMCGILL UNIVERSITY

The Montreal Neurological Institute (MNI) is estab-lishing a research group of five molecular and/or cellularneurobiologists to study mechanisms of neuronal surviv-al. Neurotrophins and other survival-promoting mole-cules will be one, although not the only, research focus.A mid-career or senior scientist with a strong publicationrecord and funding history is being sought as groupleader. Other appointments will be made at appropriateranks with McGill University's Faculty of Medicine. Thegroup will be housed in newly developed laboratoryspace and provided with ample set-up funds. The aca-demic environment and collaborative potential for neu-roscience at the MNI, at McGill and in Montreal areexcellent. Montreal is a cosmopolitan, bilingual cityknown for its high quality of life.

Applications should be sent to: Dr. Richard A. Mur-phy, Director, Montreal Neurological Institute, 3801University Street, Montreal, Quebec, H3A 2B4. Thedeadlipe for receipt of applications is 31 August 1992.McGill University is committed to Equity in Employment.

SENIOR PROGRAMMER/ANALYST IN CRYS-TALLOGRAPHY to participate in the further develop-ment of software and algorithms used in protein crystal-lography. The individual will work closely with Drs.Hendrickson and Bourne. A Ph.D. in x-ray crystallographyor a closely related field, with at least 4 years of experiencewith Fortran and C programming is prerequisite. Send,FAX, or Email curriculum vitae and the names of threereferences to: Dr. Philip E. Bourne, Howard HughesMedical Institute, Coumbia University, 630 West168th Sweet, New York, NY 10032. FAX: 212-305-7379; Email system@cuhhcahhmi.columbiaedu.

POSITIONS OPEN

FACULTY OF SCIENCE AND TECHNOLOGY(NATHAN CAMPUS)

RESEARCH SCIENTISTNMR SPECTROSCOPY

5-YEAR FIXED-TERM APPOINTMENT(READVERTISED); Ref F5-92

The appointee will take responsibility for the operationand maintenance of the new NMR Facility comprisingone 600-, one 400- and two 200-MHz spectrometers,supported by a network of UNIX-based workstations.

Duties will include supervision of spectrometer usage,training of users, and development and implementationof new NMR methods to support diverse interdiscipli-nary research projects in the School of Science. It isexpected that the appointee will undertake research inco aboration with existing research groups or set up anindependent research program. There will also be theopportunity to undertake a small amount of teaching ofNMR spectroscopy to honors and postgraduate researchstudents.A relevant Ph.D. together with substantial experience

in NMR spectroscopy and familiarity with the operationand maintenance of state-of-the-art NMR instrumenta-tion are essential.Appointment will be made at Research Fellow Grade I or

II level commensurate with qualifications and ex-perienceand will be within the following ranges: Research FellowGrade II: A$39,463 to A$48,688 per annum; ResearchFellow Grade I: A$30,340 to A$37,618 per annum. Theposition is renewable after the 5-year fixed-term period.We invite expressions of interest, indicating your area

of expertise, by facsimile +61 7 875-7656 to: TheFaculty Administrator, Faculty of Science and Tech-nology, by 19 June 1992.

Griffith UniversityQueensland 4111AUSTRALIA

An Equal Opportunity Employer.

STAFF SCIENTISTExperienced in molecular techniques/hematology. Re-

sponsible for the coordination and development of astem cell analysis program for an outpatient cancertreatment facility. Qualified candidates send a letter ofapplication and resume to: Dr. Bonni J. Hazelton,Response Technologies, Inc. (RTI), 1775 MoriahWoods Boulevard, Suite 11, Memphis, TN 38117.RTI is an Equal Opportunity Employer.

ANNOUNCEMENTS

PAYING TOO MUCH FOR YOURD-MYO-INOSITOL PHOSPHATES?

Quality synthetic 1P3's and IP4 available at low prices;99% chemical and optical purity; free of isomeric impu-rities and calcium. Ins(1,4,5)P3 potassium salt: $25/mg;Ins(1,3,4)P3 potassium salt: $300/mg; Ins(1,3,4,5)P4potassium salt: $300/mg. Substantial discounts for or-ders of 10 mg and up. For technical information or toplace an order: URI Foundation Chemical Group,133 Fogarty Hall, Kingston, RI 02881; telephone:401-792-2761; FAX: 401-792-2181.

WORKSHOP, ACID PHOSPHATASE (ACP1)26-27 SEPTEMBER 1992

ROME, ITALYTOPICS COVERED: Hystory of research on

ACP1 * Genetics of ACP1 * Function and biochemicalmechanisms of ACP1 * Modulation of activity of ACP1-Human adaptability and ACP1. * Future research onACP1.INVITED SPEAKERS: * E. Bottini, Italy; J. Dis-

sing, Denmark; D. Hopkinson, England; * H. Mohren-weiser, USA; * G. Sensabaugh, USA.

For information contact:Professor E. Bottini

Dipartimento di ChirurgiaII Universita di Roma-Torvergata

Via 0. Raimondo, 100173 Roma, Italy

Tel-FAX-39-6-72592852

POSITIONS OPEN

SOFTWARE ENGINEER. Requires Ph.D. orequivalent in Computer Science with specialization indesign and implementation of distributed languages,concurrent object-oriented languages, compiler technol-ogy and runtime support systems for distributed envi-ronments, and 3 years ofexperience in software engineer-ing, including compiler design and implementation, ob-ject-oriented concurrent language design, distributedlanguage design, and application development using Cand UNIX. To lead team in architecting, designing andimplementing an object-oriented interface definition lan-guage and compiler for a distributed object managementfacility. Also responsible for managing the relationshipwith a joint development partner for this language andcompiler. Salary: $75,200 per year. Forty hours perweek. Job site/interview: Mountain View, California.Clip ad and send with r6sum6 no later than 19 June 1992to: Job #MLM #15470, P.O. Box 9560, Sacramento,CA 95823-0560. Upon hire must show immediate abilityto work in the United States. Equal Opportunity Employer.

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NBS traceable calibration standards and controls. Largeassortment of diameters from 0.02 to 2000 pm. micro-spheres of polystyrene, glass and fluorescent materials.Free catalog available. Toll Free 800-334-3883.In Callf. 415-962-1100. FAX 415-962-0718 ICircle No. 11 on Readers' Service Card

PROTEIN KINASE CPurified from rat brain - High activity

$140/gg (plus shipping)Dome Research Laboratories

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SCIENCE * VOL. 256 * 5 JUNE 1992146

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