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Photonic technologies applied for the rapid diagnosis of diseases

Ricardo Diaz rdiaz@ainia.es

Photonics Roadshow in Newcastle3-4th April 2019

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AINIA technological centre

Light interaction in tissues

Hyperspectral vision

Melanoma detection

Automatic diagnosis in colonoscopy

Our interests

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Who we are

We are a technology center whose

MISSION is to bring value to the

company by leading innovation and

technological development in a

responsible and committed way.

AINIA technological centre

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Our specialties

• Food & Health

• Food quality & Safety

• Design and Industrial Production

• Sustainability, environment

• Consumer

• Food technology

• Biotechnology

• Nanotechnology

• Electronics and communications

• Chemical Technologies

• Environmental and energetic technologies

• Packaging technologies

Priority lines Know how

Sectors

Food

Energy

Packaging

Chemistry

Cosmetics

Pharma

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In the framework of bilateral or multilateral

programs. Projects aimed at improving the

competitiveness of companies, facilitating their

entry into new businesses and countries or

incorporating developments from other

countries.

To official control agencies and analytical services.

In food safety, international food law or access to

markets overcoming technical barriers to trade.

For official bodies

R&D projects

Technical assistance

Training

Analytical services66activities

22countries

International Activity

We develop international

projects and accompany

companies on their way to

internationalization

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Infraestructures

More than 13.000 m2 of

facilities for the development of

our research activity, with a value

above 30 M €

- 8 laboratories

- 12 pilot plants

- Classrooms

- Research area

- Industrial supercritical plant

- Consumolab Madrid and Valencia

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2017 Figures

R&D Projects

193European

National

RegionalCompany 140

1817

18

73%

27%Competitive public funds

Company private funds 2017 Revenue

14,7M€

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LIGHT INTERACTION IN TISSUES

Results of MEDISCAN Research Project funded by regional government in Spain.

Main objective: to investigate the application of new photonic technologies and evaluate their capacity to detect the presence of cancer cells in human tissues.

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HYPERSPECTRAL VISION

Hyperspectral imaging is a technique that obtains the spectral fingerprint of each point of the sample by optical methods able to decompose the light captured in each of its wavelengths, having also the information of the spatial distribution.

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MELANOMA EARLY DETECTION SYSTEM BASED ON HYPERSPECTRAL VISION

• 160,000 cases of melanoma diagnosed each year around the world.

• Melanoma: the most deadly malignant tumor of the skin cancers.

• More than 60% of the deaths by this type of tumors in some regions.

• It is spread by the lymphatic system and blood.

• It is vital to detect melanoma and its complications early through frequent skin scans.

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A rapid and non-invasive early melanoma detection system has been developed based on the analysis of the interaction of infrared light with the skin through hyperspectral vision.

Real tests have been performed with patients using the infrared spectrum to find the characteristic spectral fingerprint of tissues that may be affected by a melanoma lesion.

In the clinical study, 100% detection was achieved without false positives. In addition, by processing the image, it has been possible to define the area affected by the lesion, which is very useful for possible surgical interventions

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©AINIA and IISLAFE

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Application

These results can be applied in Dermatology in medical consultations, centres of specialtiesand hospitals.

A prototype has been built in laboratory environment and it has been successfully testedwith patients.

©AINIA and IISLAFE

COLABORATION SOUGHT

AINIA and LA FE Hospital are interested in the collaboration witha medical equipment manufacturer partner for thedevelopment and commercialization of the technology, in orderto improve the efficiency in the early detection of melanoma.

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AUTOMATIC DIAGNOSIS IN COLONOSCOPY

• Colorectal cancer is originated from an adenomatous polyp in the colon.

• Diagnosis is based in colonoscopy, with a biopsy and a subsequent anatomical-pathological analysis of the tissue.

• Treatment is usually surgical, and in many cases it is followed by chemotherapy.

• It is the 3rd most common cancer and 2nd most important cause of mortality associated with cancer in America.

• Colorectal cancer causes 694,000 deaths worldwide each year.

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We have developed a new technic able to measure the optical properties of live tissues and discriminate between diseased and healthy cells from internal human organs difficult to be explored and diagnosed with current instruments such as optical endoscopy with conventional machine vision.

The innovative method combines a flexible endoscope with a snapshot hyperspectral camera to capture the spectral fingerprint of an area of interest, identifying the type of tissue with a real-time analysis software, able to create a chemical image of that area, to help doctors discriminate internal tissues affected by diseases from healthy ones.

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Main advantages of the developed solution:

▪ Better diagnosis of colon cancer providing doctors a tool able to identify precisely which cells are affected by cancer and which are healthy to reduce the rate of false positives and false negatives in cancer diagnosis.

▪ Reduction of waiting lists: with a better diagnosis, the need for repeated or additional tests will be reduced, decreasing consequently the waiting lists in health systems.

▪ Earlier detection of cancer: the earlier the more effectively the treatment work.

▪ Increase in life expectancy.

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Application

The application of these results is in endoscopy services in hospitals.

The current state of the technology is a prototype built in laboratory environment, testedsuccessfully with patients.

©AINIA and IISLAFE

COLABORATION SOUGHT

AINIA and LA FE Hospital are interested in the collaboration with a medical equipmentmanufacturer for the development and commercialization of the technology, in order toimprove the efficiency in the early detection of colon cancer.

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OUR INTERESTS

Finally, the reason we are here is to show and share with you the potential of photonic technology in Health, but also because we are interested in:

• Contact with partners to collaborate in the field of rapid diagnosis with optical techniques

• To meet medical equipment manufacturers interested in the commercialization of our results and with commercial distribution capacity in the European hospital network.

• Show you our interest, as a partner, in participating in European projects inside or outside the H2020 program.

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Thanks for your attentionRicardo Diaz

rdiaz@ainia.es625 679 334

Instrumentation & Automation Dpt.