Description Oestrogens have wide-ranging effects throughout life. In mammals, it is well known that oestrogens regulate thymic development and thymic atrophy/involution, which may entail inhibition of T lymphopoiesis and result in suppressed humoral and cell-mediated immunity. Interestingly, oestrogen seems to alter lymphocyte apoptosis and activation, thus affecting T cell phenotypes. This PhD thesis aims to investigate ontogenesis and alterations of the teleostean thymus and associated T lymphopoeisis in the context of oestrogen-exposure. The proposed project firstly intents to clarify whether a relation between oestrogen-dependent sexual development and thymus development exists in teleosts and secondly, whether (environmental) oestrogens can alter thymus volume and structure and, consequently, thymus function in fish. This research project, jointly funded by the Swiss national Science Fondation and the French Agence nationale de la recherche scientifique is conducted in close collaboration with H. Segner at the Centre for Fish and Wildlife, Bern University, Switzerland. Two fish species, the European seabass (Dicentrarchus labrax) and the zebrafish (Danio rerio) with different developmental duration and reproductive strategies will be investigated. At the laboratory of Environmental Stress and aquatic biomonitoring the focus will be on seabass and its early life stages. Candidates must hold a diploma/master degree in Biology or a comparable certificate. A wide knowledge of Immunology is required as well as competences in specific techniques (Proteomics, Secretome, immunohistochemistry, flow cytometry). An interest in ecotoxicological problems will be appreciated. The project started January 2016. Please send your complete application including CV, letter of motivation, name and address of two referees via email (preferably single pdf file) to the address below before the 1 st of July. Dr. Tiphaine Monsinjon UMR I02 Environmental Stress and aquatic biomonitoring Le Havre University 25 rue Philippe Lebon, BP 1123 F76063 Le Havre cedex Tel. : +33 (0)2 32 74 43 24 Mail : [email protected] Dr. Thomas Knigge UMR I02 Environmental Stress and aquatic biomonitoring Le Havre University 25 rue Philippe Lebon, BP 1123 F76063 Le Havre cedex Tel. : +33 (0)2 32 85 99 04 Mail : [email protected] PhD in Fish immunology - Oestrogen regulation of thymus and T cell differentiation in European seabass A PhD position is available to study the crosstalk between the immune and endocrine system as well as the development of the thymus and associated immune parameters in juvenile D. labrax. using histological, molecular and biochemical methods and proteomics.

PhD in Fish immunology - Oestrogen regulation of …PhD in Fish immunology - Oestrogen regulation of thymus and T cell differentiation in European seabass ! A PhD position is available

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Page 1: PhD in Fish immunology - Oestrogen regulation of …PhD in Fish immunology - Oestrogen regulation of thymus and T cell differentiation in European seabass ! A PhD position is available

Description

Oestrogens have wide-ranging effects throughout life. In mammals, it is well known that oestrogens regulate thymic development and thymic atrophy/involution, which may entail inhibition of T lymphopoiesis and result in suppressed humoral and cell-mediated immunity. Interestingly, oestrogen seems to alter lymphocyte apoptosis and activation, thus affecting T cell phenotypes.

This PhD thesis aims to investigate ontogenesis and alterations of the teleostean thymus and associated T lymphopoeisis in the context of oestrogen-exposure. The proposed project firstly intents to clarify whether a relation between oestrogen-dependent sexual development and thymus development exists in teleosts and secondly, whether (environmental) oestrogens can alter thymus volume and structure and, consequently, thymus function in fish.

This research project, jointly funded by the Swiss national Science Fondation and the French Agence nationale de la recherche scientifique is conducted in close collaboration with H. Segner at the Centre for Fish and Wildlife, Bern University, Switzerland. Two fish species, the European seabass (Dicentrarchus labrax) and the zebrafish (Danio rerio) with different developmental duration and reproductive strategies will be investigated. At the laboratory of Environmental Stress and aquatic biomonitoring the focus will be on seabass and its early life stages.

Candidates must hold a diploma/master degree in Biology or a comparable certificate. A wide knowledge of Immunology is required as well as competences in specific techniques (Proteomics, Secretome, immunohistochemistry, flow cytometry). An interest in ecotoxicological problems will be appreciated. The project started January 2016.

Please send your complete application including CV, letter of motivation, name and address of two referees via email (preferably single pdf file) to the address below before the 1st of July.

Dr. Tiphaine Monsinjon UMR I-‐02 Environmental Stress and aquatic biomonitoring Le Havre University 25 rue Philippe Lebon, BP 1123 F-‐76063 Le Havre cedex Tel. : +33 (0)2 32 74 43 24 Mail : tiphaine.monsinjon@univ-‐lehavre.fr

Dr. Thomas Knigge UMR I-‐02 Environmental Stress and aquatic biomonitoring Le Havre University 25 rue Philippe Lebon, BP 1123 F-‐76063 Le Havre cedex Tel. : +33 (0)2 32 85 99 04 Mail : thomas.knigge@univ-‐lehavre.fr

PhD in Fish immunology - Oestrogen regulation of thymus and T cell differentiation in European seabass

A PhD position is available to study the crosstalk between the immune and endocrine system as well as the development of the thymus and associated immune parameters in juvenile D. labrax. using histological, molecular and biochemical methods and proteomics.