Pharmaceutical Research is Too - biocomglobalpartnering.org · Companion Diagnostics (CDX) 3D Cell Culture Bioimaging Antibody Humanization High Throughput Screening ... Supplier-friendly

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Pharmaceutical Research is Too Expensive and Inefficient

WWW.SCIENTIST.COM© 2017 SCIENTIST � CONFIDENTIAL

7,600,000Die of Cancer

Every Year

The Pharma Industry Spends $150+ Billion Each Year on Research and Produces About 25 New Drugs

12,500,000Die of Heart Disease

Every Year

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7,000Rare Diseases with

No Cures


Key Problem Facing the Pharma Industry Today

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How can we produce more drugs and cut costs … at the same time?

Marketplaces Can Transform Entire Industries

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RetailMarketplace

Transportation Marketplace

HousingMarketplace

4© 2017 SCIENTIST � CONFIDENTIAL

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Lower barriers to scientific innovation and collaboration in a way not previously possible.

Create many more drugs for cancer, heart disease, diabetes and thousands of other common and rare diseases.

Significantly reduce the cost of drug research.

The Right Marketplace Can Transform Pharma Research

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ResearchMarketplace

© 2017 SCIENTIST � CONFIDENTIAL

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Connect Potential Partners in $100B Outsourced Research Market

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Access To InnovationGet online access to cutting-

edge technologies.

Researchers(Pharma and Biotech)

17,000 Suppliers (100+ Countries)

InnovationMarketplace

Simplified SourcingSource in a few mouse clicks,

with faster lead time.

Productivity GainsCompetitive sourcing brings lower

prices and reduces admin costs.

Compliance OversightReduce potential for compliance

breach for human tissues…

Reporting ToolsTrack spending based on user, supplier, location or category.



Researchers Can Now Outsource Everything But The Genius

Human BioSamples

Custom Synthesis

Genome-Editing/Crispr

Protein Production

Animal Disease Models

Histopathology

Chemical Analysis

Custom Cell Line Creation

LC/MS Bioanalysis

Assay Development

Biomarker Discovery

Companion Diagnostics (CDX)

3D Cell Culture

Bioimaging

Antibody Humanization

High Throughput Screening

Statistics/Data Analysis

Organ-on-Chips

SNP Genotyping

Protein/Peptide Sequencing

Next Generation DNA Sequencing

Single Cell Transcriptome Analysis

Bioprinting

In Vitro Hemolysis

Cytochrome P450s

Tissue Distribution

Mouse PK

Cardiac Channels

Cancer Models

Off Target Effects …

3 , 5 0 0 + R E S E A R C H S E R V I C E S A N D C U S T O M P R O D U C T S

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Latest Tools and Technologies are Found in the Innovation HubTM

Find recently commercialized

technologies as well as recent academic

breakthroughs

Hundreds of cutting-edge tools, technologies and services


Help From the Research Concierge

Relationship ManagementMS/PhD Scientists with Sourcing Expertise

• Improve user requests

• Help select best suppliers

• Ensure suppliers respond

• Help users troubleshoot

• Prepare reports


Universal Legal Agreement for Low Risk Purchases

Signed by 12 Drug Companies and 1,820+ Suppliers

Universal Purchase AgreementSupplier-friendly MSA with standard terms for low risk services. Two easy ways to amend terms. Existing agreements have priority.

CDA – Confidentiality

MTA – Material transfer

MSA – IP & dispute resolution


Example – Sourcing of Human Biological Samples

Bodily Fluids � Organs � DNA / RNA / ProteinTissue Sections � Primary Cells

A New Industry Standard:

• Standard Legal Contract

• Supplier Evaluation Questionnaire

• Supplier Management Tools

• Internal Approval Process

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Summary Stats – Sourcing of Human Biological Samples

Human sample orders across marketplace in 2015/16

Average cycle time reduction90%

Minimum savings if get more than one quote15%

Total spend on human sample orders $18M

Place to verify user & supplier compliance1© 2017 SCIENTIST � CONFIDENTIAL

1,025


Rapid Request Turn-Around

*Average time from request to final proposal (SOW)2.9days

*Average time from final proposal to purchase order5.6days

*Based on 1,025 purchase orders in 2015/16


1 Supplier >1 Supplier >5 Suppliers >10 Suppliers

# Orders 779 246 172 113

Efficiency Gain 0% 15% 19% 21%

Resulted in $0.84M in reduced sample acquisition costs. If received multiple quotes for all orders, could have saved an additional $2.6M+

Potential for Greater Savings

Total Category Spend (Human Samples) = $18M


Cost Savings Vary Based on Scientific Category

15-60%

*Savings are calculated by comparing the winning quote to the average quote

Orders 1 Supplier >1 Supplier >5 Suppliers >10 Suppliers

# Human Sample Acquisitions 779 246 172 113

Savings 0% 15% 19% 21%

# Compound Synthesis Projects 28 190 160 97

Savings 0% 45% 51% 50%

# Protein Engineering Projects 100 82 60 43

Savings 0% 20% 27% 37%

user savings

Up-to-Date Marketplace KPIs, Metrics and Spend data



Marketplace Value Proposition

ü On-Demand Purchasing (Time Savings)

ü Supplier Consolidation (Simplification)

ü Access to Latest Tools & Technologies (Innovation)

ü Reduced Overhead (Indirect Cost Savings)

ü Enhanced Competition (Direct Cost Savings)

ü Greater Compliance (Risk Reduction)


Marketplace Costs

Cost to Users (Pharma, Biotechs, Virtual …) = $0

Cost to Suppliers = 3-5% Commission on Purchases


Scientist is One of Country’s Fastest-Growing Private Companies

2015

495%

905th

2,574%

137th

15,186%

7th

19

2016 2017 (Low Est.)

% Growth*

INC 5000 Projected Position

*% Growth = Revenue - Revenue (-3yr) / Revenue (-3yr)


How Do We Do More With Less?

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Outsource Everything But The Genius™

Documents

Pharmaceutical Research is Too - biocomglobalpartnering.org · Companion Diagnostics (CDX) 3D Cell Culture Bioimaging Antibody Humanization High Throughput Screening ... Supplier-friendly