Betalactam drugs

1. T/F regarding antibioticsa) Bactericidal drugs are more effective against rapidly dividing organisms Tb) MIC(minimum inhibitory concentration) is an indicator of potency of an

antibiotic Tc) Inappropriate use of antibiotics promote antibiotic resistance Td) Initiation of empirical therapy is microbiologically guided Fe) Chemoprophylaxis is given in large bowel surgery T

2. T/F regarding antibioticsa) Benzyl penicillin is given once in 21-28 days rheumatic fever Tb) Gentamicin is well absorbed following oral administration Fc) Erythromycin is contraindicated in patients with penicillin allergy Fd) Chloramphenicol is known to cause grey baby syndrome Te) Metronidazole is used to treat pseudomembranous colitis T

3. T/F regarding beta lactam antibioticsa) Cephalosporins inhibit the formation of peptidoglycan cross links in bacterial cell

walls Tb) Benzyl penicillin is acid stable Fc) Reduced doses of benzyl penillin are required for patients with renal impairment

Td) Have a low therapeutic index Fe) Amoxicillin is beta lactamase resistant F

4. These drugs inhibit bacterial cell wall synthesisa) Macrolids Fb) Choloramphenicol Fc) Cephalosporins Td) Quinolones Fe) Carbepenams T

5. T/F regarding antimycobacterial drugsa) Dapsone is known to cause red urine Fb) Streptomycin can be safely given in pregnancy F

c) Ethambutol is known to cause optic neuritis Td) Miliary TB is treated with the standard drug regime given for 8 months Fe) Pyrazinamide is the most least likely out of the standard antiTB drugs to cause

hepatotoxicity F

Antimalarial drugs

6. Chloroquinea) is a blood schizonticidal drug Tb) produces a radical cure for plasmodium vivax infection Fc) Is contraindicated in pregnancy Fd) Has a large volume of distribution Te) Hypotension is a risk seen in intravenous administration T

7. Antimalarial drugsa) PQ hypnozoidal in P.V infection Tb) Parentral quinine causes hypoglycemia Tc) Metroquinne chemoprophylaxis in SL Fd) Quinene is contraindicated in 1st trimester Fe) Cortem is given according to weight T

Antivirals and antifungals

8. T/F in antivirals and antifungalsa) Acyclovir is given IV in herpes simplex encephalitis Tb) Acyclovir reduces the severity of herpes zoster infection if started within 24hrs of

onset of rash Tc) Tamiflu is recommended for post exposure prophylaxis of influenza in healthy

individuals Fd) Oral nystatin is effective in treatment of superficial candidacies of the mouth Te) Antacids reduce the absorption on ketoconozole T

9. T/F regarding antiviralsa) Macrolides are known to decrease anticoagulatory effects of warfarin Fb) Chloramphenicol act by inhibiting bacterial protein synthesis Tc) Tetracyclines are known to cause brownish pigmentation of teeth in children T

d) Sulphanamides are bacteriocidal Te) Erythromycin is bactericidal in high doses T

Aminoglycosides

10. Aminoglycosidesa) Are known to cause reversible otoxicity Fb) Shows time dependent killing Fc) Act by arresting the multiplication of bacteria Fd) Are effective against gram negative aerobic infections Te) Once daily dose is recommended in patients with infective endocarditis F

11. Aminoglycosidesa) Single dose in infective endorcarditis Fb) Synergistic act with benzyl penicillin Tc) Destroys cell by inhibiting cell wall synthesis Fd) Irreversible autotoxicity Te) Does not cross BBB readily T

Quinolones

12. Quinolonesa) Are used in the treatment of airway tract infections Fb) Are bacteriostatic Fc) Are safe throughout pregnancy Fd) Are more active against gram negative than gram positive organisms Te) Are known to cause tendernitis due to concomitant use of NSAIDS F

Iron therapy and vitamins

13. T/F regarding iron therapya) Taking iron with tea enhances absorption Fb) Total iron binding capacity is decreased in iron deficiency anemia Tc) Serum transferrin level is a measurement of iron stores Fd) Black stools are known to occur in iron replacement therapy Te) Ferrous fumarate has a higher efficacy than ferrous sulphate F

14. T/F regarding vitaminsa) Isoniazid can cause pyridoxine deficiency Tb) Hyperkaelemia is known to occur in the treatment of pernicious anemia Fc) Vitamin B12 absorption is dependent on lipid metabolism Fd) Vitamin A is used in the treatment of psoriasis Te) Folic acid supplements are given via the oral route T

Calcium and phosphate metabolism

15. In drug treatment for osteoporosisa) HRT(hormone replacement therapy) in post menopausal women is known to

increase the risk of endometrial carcinoma Tb) Raloxifene reduces the incidence of nonvertebral fractures Fc) Alendronate is safely prescribed in renal failured) Etidronate causes gastric irritation Te) Alendronate suppresses bone resorption by osteoporosis T

Pharmacokinetics

16. T/F regarding drug metabolisma) Zero-order metabolism applies to most drugs in clinical use Fb) In first-order metabolic processes enzyme activity is rate limiting Tc) In zero-order kinetics a constant amount of the drug is eliminated per unit time Td) In first –order kinetics, at steady rate the rate of elimination of a drug is less than

the rate of administrationFe) Alcohol at higher doses a constant fraction of the plasma concentration is

eliminated per unit time F

17. Drugs act bya) Interacting with receptors Tb) Altering the activity of enzymes Tc) Altering the metabolism of microorganismsd) Altering the membrane permeabilitye) Interfering with the activity of the ion channelsT

18. T/F regarding drugs acting on muscarinic receptors

a) Pilocarpine produces miosis due to agonism Tb) Atropine is a muscarinis agonist Fc) Ipratropium relaxes the bronchial smooth muscles Td) Propanthelin increases gastro intestinal spasms Fe) Hyoscine produces an antiemetic effect T

19. T/F regarding absorption of a druga) Most clinically used drugs are absorbed in the small intestine Tb) Absorption of drugs are independent of the Ph Fc) Rate of absorption is greater when given IM than when given SC Td) Absorption is less if the drugs are non ionized Fe) Lipid solubility enhances the absorption of drugs T

20. T/f regarding effects of Beta adrenergic agonistsa) Bronchoconstriction Fb) Negative chronotropic effect Fc) Relaxes uterine smooth muscles Td) Positive inotropic effect Te) Increase oxygen demand T

21. T/F regarding plasma half lifea) Drugs with a short half life a given orally Fb) Determines the time taken for a drug to be eliminated from the body Tc) Drugs that show zero-order elimination processes have a constant t ½ Fd) It determines the time taken to reach steady state concentration Te) Drugs that have long t ½ are given once daily T

22. T/F regarding therapeutic indexa) It is the ratio between toxic dose to the therapeutic dose Tb) Frequent dose increments of drugs with a small therapeutic index is safe Fc) Digoxin has small therapeutic index Td) Frusemide has high therapeutic index

e) Drugs that have small therapeutic index can be given more frequently without monitoring F

23. Bioavailability of a drug is dependent ona) Method of administration Tb) Molecular size Tc) Route of excretiond) First past metabolism Te) Excipients T

24. Drugs with narrow therapeutic index area) Theophillin Tb) Gentamycin Tc) Warfarin Td) Lithium Te) Digoxin T

Cholinergic and anticholinergic drugs

25. Symptoms of atropine intoxication area) Hyperthermiab) Bradycardia Fc) Mydriasis Td) Bronchocospasm Fe) Sweating F

26. Following drugs are used in myasthenia gravisa) Edrophonium Tb) Metoprolol Fc) Pilocarpine Fd) Pyridostigmine Te) Neostigmine T

Drugs used in thyroid disorders

27. T/F reagarding drugs used in thyroid disordersa) Propylthiouracil inhibits the peripheral conversion of T4 to T3 Tb) Carbimazole is converted to methimazole in vivo Tc) Agranulocytosis is a common adverse effects of carbimazole Td) Propylthiouracil is contraindicated in pregnancye) Levothyroxine is the treatment of choice for maintenance therapy in neonatal

hypothyroidism T

Adrenal steroids

28. T/F regarding adrenal steroidsa) Fluorinated steroids should be avoided during pregnancy Tb) Dexamethasone is a short acting glucocorticoid Fc) Hyperglycemia is a known side effect of corticosteroids Td) Chronic corticosteroid therapy is stopped during an infective episode Fe) Hydrocortisone is known to cause retension of salt and water

Drugs for DM

29. T/F regarding insulina) Insulin lispro is a short acting insulin Fb) Insulin is stored in the door of the refrigerator Tc) Absorption is greater when injected to the thigh compared to the abdomen Fd) Biphasic insulin consists of a long acting and short acting insulin Fe) Rapid acting preparations have a cloudy appearance F

30. Metformina) Causes weight gain Fb) Mechanism of action is dependent on the presence of functioning beta cells Fc) Has no effect on postprandial blood glucose Fd) Is contraindicated in hepatic impairment Te) Should be avoided during lactation F

31. T/F regarding oral hypoglycemic drugsa) Oral hypoglycemic drugs are generally given before meals Tb) Thiazolidinediones act by increasing insulin secretion F

c) Glibenclamide is preferred in elderly diabetic patients Fd) Sulphonylureas cause weight loss Fe) Acarbose reduces the absorption of carbohydrates T

Sex hormones

32. T/F regarding sex hormonesa) Oestradiol causes retention of salt and water Tb) Testosterone is used to treat prostatic cancer Fc) Progesterone therapy is known to cause hirsutism Td) Oestrogen reduces the risk of thromboembolism Fe) Testosterone is increased by growth hormone F

OCP

33. T/F regarding oral contraceptive pillsa) The routinely prescribed OCP is a monophasic high strength preparationb) The multiphasic pill has less metabolic adverse effects than the monophasic pill Tc) Commonly used oestrogen is ethinyloestridiol Td) Oestrogen in OCP thickens the cervical mucus Fe) Migraine with typical focal aura is a contraindication T

34. T/F regarding emergency contraceptiona) Levonorgestriol is the preparation used Tb) Interferes with an established pregnancy Fc) Should be taken within 72 hrs of unprotected sex Td) It is recommended to use a barrier method after using the emergency pill until

the next period Te) Replace the dose if vomiting occurs within 2hrs of takin the pill T ? 1 HR

Ovarian stimulants and oxytocic drugs

35. T/F regarding ovarian stimulantsa) Clomifene acts as an antagonist in the presence of endogenous oestrogens Tb) Tamoxifen improves survival in breast carcinoma T

c) Clomifene is administered during the early luteal phase of the menstrual cycle to treat infertility F

d) Tamoxifen is a partial agonist of oestrogen receptors Fe) Clomifene reduces the risk of ovarian carcinoma F

36. T/Fa) Ergometrine causes rhythmic contractions Fb) Hypertension is a common side effect of oxytocin Fc) Misoprostol induces abortion Td) Salbutamol is given to delay premature labour Te) Prostaglandins inhibit uterine contractions F

Best of five

37. Which of the following drugs is most likely to cause hypoglycemiaa) Methforminb) Acarbosec) Tolbutamided) Insulin Te) glitazone

38. In which of the following conditions is tertracycline the drug of first choicea) Amoebiasisb) Treatment of chronic hyponatremia due to ACTH secretionc) Prophylaxis of malariad) Mycoplasma pneumonia Te) Soft tissue infections in patients who are allergic to beta lactam T

Macrolides

39. Macrolidesa) Erythromycin induce p450 enzyme Fb) Time dependent killing Tc) Used in atypical pneumonia Td) Penicillin resistance, given as substitute Te) Is a protein synthesis inhibitor

40. Drugs causing hepatic inductiona) Rifampicin Tb) Erythromycin Fc) Ethanol Td) Carbemazepine Te) Penicillin

41. Antidotesa) Methanol-ethanol Tb) Iron-desferixamin Tc) Opiods-flumazenil Fd) Digoxin-atropine Te) TAC-naloxone F

42. Diazepama) Antagonist of GABA receptors Fb) Effective in the management of status epilepticum Tc) Long term use cause dependence Td) Rapid iv administration cause resp. depression Te) Reduces anxiety T

43. Antidepressantsa) Tricyclics-start with a low dose Tb) Imipramine-selective serotonin uptake inhibitor Fc) Imipramine-more cardiotoxic than fluxetine Td) Salt free diet is recommended when lithium is given Fe) Are addictive F

44. Antiepileptica) Carmazepine-inhibit GABA Fb) Phenytoin-gingival hyperplasia Tc) Folic acid given all epileptic women in their childbearing age Td) Sodium valproate-tratment of absence seizure Te) Carbemazepine-induces its own metabolism T

45. Antipsychotic drugsa) All act by blocking dopamine D2 receptors Tb) Risperidone-less extrapyramidal symptoms than chloprmazin Tc) Chlorpromazine-effective in resistant schizophrenia Fd) Clozapine-fatal agranulocytosis Te) Chlorpromazine-no sedative effect F

46. T/F of peptic ulcer diseasea) Effects of H2 receptor blockers are enhanced post-pandrially Fb) AL-diarrhoea Fc) Simeticone-reduce flatulence Td) Omeprazole-accumulate in areas of low PH Te) Omeprazole is a pro drug T