PG VCI Syllabus3010.doc

M

ANNEXURE I

Semester wise breakup of Courses

in M.V.Sc. (Veterinary Pharmacology & Toxicology)

1st semester

Sr. No.Course NoTitlecreditsTotal credits

1VPT 601General Pharmacology2+02

2VPT 602Autonomic & Autacoid Pharmacology2+13

3VPT 604Digestive & Respiratory Pharmacology2+02

4VPT 605Cardiovascular & Renal Pharmacology2+02

5PGS 501

Noncredit compulsory coursesLibrary and information services0+1----

Total 9 credits

Major

9 credits

Minor & Supporting6 credits

2nd Semester


1VPT 603CNC Pharmacology2+13

2VPT 607Chemotherapy2+13

3VPT 608Toxicology of Xenobiotics2+13

4VPT 612Ethenopharmacology2+02

5PGS 502

Noncredit compulsory coursesTechnical writing and communication skills0+1----

6PGS 503 (e course)Noncredit compulsory coursesIntelectual property and its management1+0

Total 11 credits

Major

11 credits

Minor & Supporting5 credits

3rd semester


1VPT 606Endocrine & Reproductive Pharmacology2+02

2VPT 609Toxicology of Plants & Toxins2+12

3VPT 610Pharmacological techniques1+12

4VPT 611Techniques in Toxicology1+12

5VPT 691Masters seminar0+11

6VPT 699Master Research0+55

5PGS 506 (e course)Noncredit compulsory coursesDisaster management 1+0----

Total 14 credits

Major

14 credits

4th semester


1VPT 699Master Research0+1515

Total 15 credits

Major

15 credits

MINOR SUBJECTS

1. Vet. Physiology

2. Vet. Biochemistry

3. Vet. Clinical Medicine

4. Vet. Ethics & Jurisprudence

5. Vet. Pathology

6. Animal Biotechnology

LECTURE SCHEDULE

VPT 601 General Pharmacology 2+0 = 2

Unit 1

1. Historical development

2. Scope of veterinary Pharmacology

3. Transport of drugs across biological membranes

4. Principles of drug absorption

5. Factors affecting absorption and transporters

6. Distribution of drugs

7. Factors affecting drug distribution- plasma protein binding, passage of drugs across placenta, blood brain barrier

8. Biotransformation of drugs- introduction, Phase I reaction

9. Biotransformation of drugs- introduction, Phase II reaction

10. Factors affecting drug metabolism, microsomal enzymes

11. drug excretion renal, hepatic and other ways

12. Bioavailabilty & bioequivalence

13. Species variation in action of drugs

Unit 2

14 Important pharmacokinetic parameters & calculations

15 Compartmental, non Compartmental analysis

16 Clinical significance of pharmacokinetics

Unit 3

17 Introduction to mechanism of actions

18 Dose response curves

19 Therapeutic index, Therapeutic ratio and its significance

20 Non-receptor mediated actions

21 Receptors types ion channels receptors

22 Receptors types G Protein coupled receptors

23 Nuclear receptors

24 Silent receptors, spare receptors

25 Kinase linked receptors

Unit 4

26 Quantitation of drug receptor interactions and its effects

27 Antagonism types

28 Competitive antagonism

29 Non competitive antagonism

30 Factors affecting drug response

31 ADRs

32 Recent advances

LECTURE SCHEDULE

VPT 602 Autonomic & Autacoid Pharmacology 2+1 = 3

Unit 1

1. Introduction to nervous system

2. Anatomical considerations of ANS

3. Physiological considerations of ANS

Unit 2

4 Neurohumoral transmission conduction and synthesis of nerve impulse

5 Storage, release and receptor events in NT

Unit 3

6 Synthesis, storage and catabolism of ACh

7 Cholinergic receptors- Muscarinic

8 Cholinergic receptors- Nicotinic

9 Cholinergic agonists

10 AchE inhibitors reversible

11 AchE inhibitors - irreversible

12 Cholinergic antagonists

Unit 4

13 Synthesis, storage, catabolism of NE

14 Adrenergic receptors , 15 Adrenergic antagonists neuron blockers

16 Adrenergic antagonists receptor blockers

17 Clinical uses of adrenergic and anti adrenergic drugs

Unit 5

18 Ganglionic stimulants

19 Ganglionic blockers

Unit 6

20 Histamine pathophysiology

21 Classification of histaminic receptors

22 Clinical uses of antihistaminic drugs

23 5HT physiological roles

24 Seratoninergic receptors and receptor activators / blockers

25 Kinins physiological roles

26 Drugs acting on kinins

27 Eicosanides PGs, leukotrines etc.

28 Platelet activating factors

29 Drugs modifying Eicosanides cascade NSAIDS

30 Recent advances

PRACTICALS

Animal experimentation models on intact & isolated preparations

Intact

1. Rat blood pressure

2. Effect of drugs on rabbit eye (pupil)

3. Guinea pig tracheal chain

4. Guinea pig illium

5. Rabbit jejunum

6. Rat uterus

7. Frog rectus abdominis muscle

8. isolated heart (Rabbit / guinea pig)

9. Demonstration of ECG

10. Effect of drugs on urine output

(Above experiments may be explained with the help of computerized simulated experimentations incase lab animals are not available)

LECTURE SCHEDULE

VPT 603 CNS Pharmacology 2+1 = 3

Unit 1

1. Anatomy of CNS

2. Physiological considerations

3. various neurotransmitters of CNS

4. Neurohumoral transmission in CNS

Unit 2

5 Introduction to general anesthesia and historical development

6 Theories of general anesthesia

7 Stages of general anesthesia

8 Classification of general anesthesia

9 Anesthetics for small animals

10 Anesthetics for large animals

Unit 3

11 Classification of drugs acting on CNS

12 Sedatives

13 Hypnotics

14 Neuroleptics

15 Antiepileptics

Unit 4

16 CNS stimulants drugs acting on cortex

17 Medullary and Sp. Cord stimulants

18 Opoid receptors

19 Opioid agonists and antagonists

20 -2 receptors agonists & antagonists

21 NSAIDS

22 Central muscle relaxants

23 Curarizing agents

24 Noncurarizing and other muscle relaxants

25 Local anesthetics

26 Therapeutic gases role of NO227 Oxygen, CO228 Euthanizing agents

29 Doping

30 Recent advances

PRACTICALS

1. Induction of anesthesia in lab animals

2. Screening of analgesic activity

3. Screening of CNS depressants

4. Screening of CNS stimulants

5. Screening of muscle relaxants

6. Screening of anti-inflammatory activity

7. Screening of antipyretic activity

8. Potentiation of anesthesia by premedicants

9. Screening of anticonvulsant activity

10. Induction of local anesthesia in small animals

LECTURE SCHEDULE

VPT 604 Digestive and Respiratory Pharmacology 2+ 0 = 2

Unit 1

1. Anatomical considerations of GIT in different spp.

2. Physiological considerations of GIT

3. Appetite stimulants sialics

4. Antisialics

5. Emetics

6. Antiemetics

Unit 2

7 Modulation of gastric and intestinal motility

8 Ant ulcer drugs prokinetics

9 Gastric sedatives

Unit 3

10 Laxatives and cathartics

11 Classification and mechanism of actions of cathartics

12 Classification and mechanism of actions of cathartics

13 GI protectants and adsorbents

14 Opoid and other agents used in diarrhea

Unit 4

15 Agents promoting digestive functions- Enzymes

16 Hepatoprotectants

17 Rumen physiology

18 Rumen dysfunctions

19 Pharmacology of drugs acting on rumen

20 Recent developments in rumen Pharmacology

Unit 5

21 Bronchoconstrictors

22 Pathogenesis of inflammatory respiratory diseases

Unit 6

23 Bronchodilators

24 Antitussives

25 Mucolytics

26 Expectorants

27 Decongestants

Unit 7

28 Management of asthma

29 Recent advances

LECTURE SCHEDULE

VPT 605 Cardiovascular and Renal Pharmacology 2+ 0 = 2

Unit 1

1 Path physiology of CHF

2 History and classification an sources of cardiac glycosides

3 Mechanism of action & kinetics of cardiac glycosides

4 Digitalization and supportive therapy of CHF

Unit 2

5 Cardiac action potentials and path physiology of arrhythmia

6 Classification of antiarrythmic drugs

7 Class I, II antiarrythmic drugs

8 Class III, IV antiarrythmic drugs

9 Potassium channel regulators

10 Path physiology of hypertension

11 Classification and mechanism of action of important antihypertensive drugs

12 Management of hypertension

13 Antihyperlipidemic drugs I

14 Antihyperlipidemic drugs II

Unit 3

15 Drugs affecting vasomotor and cardio respiratory reflex mechanisms

16 Hemopoitic system antianemic drugs

Unit 4

17 Coagulants

18 Anticoagulants

19 Thrombolytic agents

Unit 5

20 Diuretics classification

21 Diuretics continued

22 Clinical uses of diuretics

23 Body fluid compartments and electrolyte balance

Unit 6

24 Concept of Osmolality and Osmolarity

25 Different types of electrolyte fluids

26 Fluid requirement in dehydration

27 Plasma volume expanders

28 Antidiuretics

29 Uricosuric agents

30 Recent advances

LECTURE SCHEDULE

VPT 606 Endocrine and Reproductive Pharmacology 2+ 0 = 2

Unit 1

1 Hormones & Their analogues regulating pituitary functions I

2 Hormones & Their analogues regulating pituitary functions II

3 Thyroid hormone functions clinical uses

4 Antithyroid drugs

5 Adrinocorticoids Natural

6 Adrinocorticoids synthetic

7 Adrinocorticoids - synthetic

8 Hypoglycemic agents

9 Insulin

10 Management of diabetes

Unit 2

11 Roles of calcium and phosphorus

12 Calcium Phosphorus homeostasis

13 Various Calcium & Phosphorus supplements used in veterinary practice

Unit 3

14 Androgens

15 Antiandrogens

16 Drugs affecting libido

Unit 4

17 Oestrogenic drugs

18 Antioestrogenic drugs

19 Drugs used in synchronization of oestrus

20 Drugs used in misalliance and for inducing abortions

21 Galactogogues

22 Lactation suppressants

23 Drugs used for maintaining pregnancy

24 Drugs used for retained placenta

Unit 5

25 Oxytocic agents

26 Tocolytic agents

27 Recent advances

LECTURE SCHEDULE

VPT 607 Chemotherapy 2+1 = 3

Unit 1

1 General considerations

2 Principles of chemotherapy

3 Classification of chemotherapeutic agents I

4 Classification of chemotherapeutic agents II

5 Microbial resistance I

6 Microbial resistance II

7 Antimicrobial combinations

Unit 2

8 Sulfonamides

9 Potentiated sulfonamides

10 Nitrofurans, sulfones

11 Quinolones

Unit 3

12 Penicillins

13 Semisynthetic penicillins

14 Cephalosporins

Unit 4 Broadspectrum Antibiotics

15 Chramphenicol florphenicol

16 Tetracyclines

17 Macrolids

18 Polypeptide antibiotics

19 Polymixins

Unit 5

20 Aminoglycosides

21 Other antibiotics

Unit 6

22 Pharmacology of hemoprotozoan diseases

23 Pharmacology of entero protozoan diseases

24 Coccidiostats I and II

25 Anthelmintics classification and mechanism of action

26 Antinematodal drugs

27 Anticestodal and antitrematodal drugs

28 Ectoparasiticides IGR, IDL

Unit 7

29 Antifungal drugs

30 Antiviral drugs

31 Antineoplastic drugs

32 Antitubercular drugs

PRACTICALS

1. General methods of assay of antibacterials

2. General methods of assay of sulfonamides

3. General methods of assay of OTC

4. General methods of assay of penicillins

5. General methods of assay of Trimethoprimes

6. General methods of assay of Nitrofurans

7. Antibiotic sensitivity test

LECTURE SCHEDULE

VPT 608 Toxicology of Xenobiotics 2+1 = 3

Unit 1

1 History of Toxicology

2 Scope of toxicology

3 Sources of Poisoning and classification

4 Classification of poisons

5 Types of toxicities

Unit 2

6 General mode of action of poisons

7 Portals of entry of poisons and absorption of poisons

8 Distribution of poisons

9 Metabolism of poisons

10 Excretion of poisons

11 Factors affecting toxicity

12 Diagnosis of poisoning

13 Principles of treatment of poisoning

Unit 3

14 Toxicology of metals Alluminium, Antimony, Arsenic,

15 Toxicology of metals Bismuth, cadmium, Chromium,

16 Toxicology of metals cobalt, copper,

17 Toxicology of metals lead, Manganese, mercury,

18 Toxicology of metals molebdinum, Nickel, Selenium,

19 Toxicology of metals Zinc, Silver, Tin, Thallium

20 Toxicology of agrochemicals organochlorines

21 Toxicology of agrochemicals Organic phosphate compounds

22 Toxicology of agrochemicals carbamates, pyrethrides

23 Toxicology of agrochemicals herbicides

24 Toxicology of agrochemicals rodenticides

25 Toxicology of solvents and vapors

26 Toxicology of feed additives

Unit 4

27 Toxic effects of radiation and radioactive chemicals

28 Introduction to genetic and developmental toxicology

29 Forensic toxicology

30 Regulatory toxicology

PRACTICALS

1 Demonstration of toxicity and its antidotal treatment in lab animals

2 Acute toxicity

3 Sub acute toxicity

4 Chronic toxicity

5 Immunotoxicity

6 Genotoxicity testing

7 Eee irritation test

8 Dermal toxicity study

9 Extraction, separation and detection of common poisons in toxicological specimens

10 Spot test for detection of heavy metal

LECTURE SCHEDULE

COURSE TITLE:-TOXICOLOGY OF PLANTS AND TOXINS

COURSE NO.:-VPT 609 CREDIT :-( 2+0)

Unit 1

1. Introduction to plant toxicology, Toxins, Venoms, Mycotoxins, Mycotoxins, Bacterial toxins and Phytotoxins.

2. Classification and identification of Chemical constituents of poisonous plants. (alkaloids, glycosides, phytoagglutinins, phenol)

3. Phytotoxins their sources and effects.

4. Phytotoxins their sources and effects---- contd..

5. Phytotoxins their sources and effects.

6. Classification of toxins (Phytotoxins, Microbial toxins)

7. Study of toxicity of plants containing cyanide.

8. Study of toxicity of plants containing cyanide.

9. Study of nitrates/nitrites containing plants and their toxic effect.

10. Study of plants containing oxalates and their toxic effect.

11. Study of plants containing lectins and cardiac glycosides-I.

12. Study of plants containing lectins and cardiac glycosides-II

Unit 2

13. Study of plants producing lathyrism.

14. Thiamine deficiency, toxicity of plants.

15. Photosensitization and toxicity of plants causing photosensitization-I.

16. Photosensitization and toxicity of plants causing photosensitization-II

Unit 3

17. Study of Mycotoxins Aflatoxins and Rubratoxins.

18. Study of Mycotoxins Ochratoxin, Trichothecores.

19. Study of Mycotoxins- Tremorgons and ergot.

Unit 4

20. Study of Snake venoms and their toxic effects.

21. Study of Snake venoms and their toxic effects.

22. Study of Scorpion bite and their toxic effects.

23. Study of spider bite and their toxic effects.

24. Study of different insect bites and their toxic effect (bees, wasps, hornets etc).

25. Study of Toad toxins.

26. Classification and character of bacterial toxins- Endotoxins and Exotoxins.

27. Classification and character of bacterial toxins- Endotoxins and Exotoxins.

28. Toxicity caused by tetanus spasmins.

29. Study of Botulism.

30. Recent advances

COURSE TITLE:-PHARMACOLOGICAL TECHNIQUINES

COURSE NO.:-VPT-610

CREDIT :-( 1+1)

Unit 1

1. Principles of drug action.

2. Bioassay. Types of bioassay, bioassay techniques

3. Bioassay. Types of bioassay, bioassay techniques

4. Study of dose response relationship (guinea pig ileum).

5. Study of dose response relationship (spinal cat).

6. Demonstration of Suprmaximal effect by cumulative dose response study.

Unit 2

7. Study on isolated guineas pig ileum.

8. Study on isolated rat uterus.

9. Study on isolated frog rectus abdominis preparation.

10. Study on intact frog heart perfusion.

11. Recording of blood pressure in anesthetized rats.

12. Recording blood pressure in dog.

Unit 3

13. Organization of screening Programme of drugs (general screening procedure).

14. Multidimensional screening procedure.

15. Multidimensional screening procedure.

16. Gross observational methods in screening procedures

PRACTICAL

COURSE TITLE:-PHARMACOLOGICAL TECHNIQUINES

COURSE NO.:-VPT-610

CREDIT :-( 1+1)

1. Setting up of an isolated tissue preparation and an intact preparation.

2. Recording of blood pressure in Dog/Rat (Studies on intact preparation).

3. Recording of ECG in Rats.

4. Demonstration the potentiation of Epinephrine pressor response by Ephedrine.

5. Demonstrate specificity of antagonisms.

6. Demonstrate phenomenon of Tachyphylaxis.

7. Study dose response relationship.

8. Calculation of EC50, potency ratio, PDv, PDx and PD values.

9. Screening of Hypnotic activity.

10. Study of analgesic, antipyretic and anti-inflammatory activity in laboratory animals.

11. Study of general and local anesthesia in experimental animals.

12. Study anticonvulsant and muscle relaxant effect of drugs in rats/mice.

13. Study of antiarrhythmic and antihypertensive action of test compound.

14. Study of antihyperglycemic and Anticholesterimic activity.

15. Calculate ED50 of LD50 of a given drug.

16. Bioassay techniques.

Above experiments may be explained with the help of computerized simulated experimentation in case lab animal facilities are not available

THEORY

COURSE TITLE:- TECHNIQUES IN TOXICOLOGY

COURSE NO.:-VPT-611

CREDIT :-( 1+1)

Unit 1

1. Study of animals models for toxicological studies.

2. Study of animals models for toxicological studies.

Unit 2

3. Study animal toxicity tests for acute, sub acute and chronic toxicity.

4. Study animal toxicity tests for acute, sub acute and chronic toxicity.

Unit 3

5. Study specific toxicity test for Neurotoxicity.

6. Study specific toxicity test for Immunotoxicity

7. Study specific toxicity test for Developmental toxicity.

8. Study specific toxicity test for Behavioral toxicity.

9. Study specific toxicity test for Mutagencity.

10. Study specific toxicity test for Reproductive toxicity.

11. Study specific toxicity test for Inhalation toxicity.

12. Study specific toxicity test for Carcinogenicity- preliminary Carcinogenicity, full scale Carcinogenicity.

Unit 4

13. Study animal toxicological tests for study metabolism.

14. Animal toxicological tests for synergism.

15. Animal toxicological tests for study of antagonisms.

16. Recent advances

PRACTICAL

COURSE TITLE: - TECHNIQUES IN TOXICOLOGY

COURSE NO.:-VPT-611

CREDIT :-( 1+1)

1. Study test for acute toxicity.

2. Study test for sub-acute toxicity

3. Study test for chronic toxicity

4. Protocol for specific toxicity test



7. Marker enzyme assay

8. Analysis of toxicant residues in biological materials



COURSE TITLE: - ETHNOPHARMACOLOGY

COURSE NO.:-VPT-612

CREDIT :-( 2+0)

Unit 1

1. Introduction & historical aspects of traditional Indian remedies in disease cure.

2. Historical aspects of regional folk fare in disease cure.

Unit 2

3. Classification of medicinal plants on chemical basis.

4. Identification different tests for analysis of medicinal plants.

5. Phytopharmaceuticals chemical constituents of medicinal plants.

6. Extraction of medicinal plants different types of herbal extracts.

7. Extraction of medicinal plants solvents or agents used for extraction.

8. Different process of extraction.

9. Distillation/ evaporation and other processes used in purification.

10. Different processes used in purification and preparation of active constituent from medicinal plants.

Unit 3

11. Standardization different methods of standardization of bioactive from vegetable sources.

12. Clinical validation of bioactive molecules from vegetable source - animal species, disease model.

13. Test assay-whole animal, isolated organ and tissue, blood and its components, ex-vivo and tissue culture cells and subcellular constituents.

14. Clinical validation- acute toxicity test, long term toxicity tests, local toxicity tests.

15. Therapeutic effects of potential herbal drugs.

16. Adverse effects of potential herbal drugs.

17. Indigenous drugs used as carminatives agents.

18. Indigenous drugs used as antiseptics or bacteriostatic agents.

19. Indigenous drugs used as antimicrobial agents.

20. Indigenous drugs used as analgesics agents.

21. Indigenous drugs used as anti-inflammatory agents.

Unit 4

22. Alternate systems of medicine in animals.



25. Recent advances in herbal drugs

MASTER SEMINAR

VPT 691 0+1

MASTER RESEARCH

VPT 699 20

ANNEXURE iI


in Ph.D. (Veterinary Pharmacology & Toxicology)

for regular candidates

SemesterMajor credit loadMinor credit loadTotal credit load

(19)(11)

1st7613

2nd6+1512

3rd6+107

Total 32

4th 45 credits

5th

6th

Course work

32 credits (21 major + 11 Minor)

Research

45 credits (45)

------------------------------------------------------------------------------------------

Total 77 credits

Semester IV, V and VI Research work



for in service candidates

SemesterMajor credit loadMinor credit loadTotal credit load

(19)(11)

1st549

2nd538

3rd5 + 1 credit seminar49 + 1 seminar

4th 4 + 1 credit seminar04 + 1 seminar

Total 32

Course work

32 credits (21 major + 11 Minor)

Research

45 credits (45)

------------------------------------------------------------------------------------------

Total 77 credits

Semester V, VI, VII and VIII - Research work



for regular candidates

1st semester


1VPT 703Pharmacology of Herbal drugs2+13

2VPT 705Molecular Pharmacology2+02

3VPT 709Molecular Toxicology2+02

Total 7 credits

2nd Semester


1VPT 710Clinical Pharmacology1+12

2VPT 711Clinical Toxicology2+13

3VPT 791Doctoral Seminar I0+11

Total 5 + 1 credit seminar

3rd semester

Sr. No.Course NoTitleCreditsTotal credits

1VPT 713Regulatory Toxicology2+13

2VPT 790Special Problem0+22

3VPT 792Doctoral Seminar II0+11




for in service candidates

1st semester


1VPT 703Pharmacology of Herbal drugs2+13

2VPT 705Molecular Pharmacology2+02

Total 5 credits

2nd Semester


1VPT 709Molecular Toxicology2+02

2VPT 711Clinical Toxicology2+13

Total 5 credit

3rd semester

Sr. No.Course NoTitleCreditsTotal credits

1VPT 710Clinical Pharmacology1+12

2VPT 790Special Problem0+22

3VPT 791Doctoral Seminar I0+11


4th semester


1VPT 713Regulatory Toxicology2+13

3VPT 792Doctoral Seminar II0+11


LECTURE SCHEDULES FOR Ph.D. IN VETERINARY PHRMACOLOGY

AND TOXICOLOGY

VPT- 701 ADVANCES IN PHARMACODYNAMICS 2+0=2

Theory

UNIT- I

1 Introduction to principles of mechanism of action of drugs

2 Drug action with regard to receptors, ion channel, enzymes &

Transporters

3 .continued..

4 Definition of receptors and their classification and drug effects

5 Molecular structure of receptors. Receptor regulation

6 Receptor for physiological regulatory molecules.nature of receptors and subtype

UNIT- II

7 G-protein coupled receptors

8 Ligand gated ion channels, voltage gated ion channels

9 Tyrosin kinase linked receptors

10 Receptor regulating gene expression

11 Enzyme linked receptors

12 Functions of receptors

UNIT-III

13 Ligand binding study of receptors

14 Introduction to signal transduction

15 Receptors linked to ion channel

16 Control of receptor expression

17 Receptors and disease

UNIT-IV

18 G-protein and their role

19 Cytoplasmic second messengers

20 Major effector pathways of G- protein coupled receptors

21 Phospholipases as effector pathways through which GPCR functions

22 Phosphokinases as -------------------------- do ---------------------------------

23 Intracellular calcium as -------------------------- do ---------------------------------

24 Protein kinase C as -------------------------- do --------------------------

25 Diacylglycerol and IP3 -------------------------- do -----------------------

26 Cyclic nucleotides as -------------------------- do --------------------------

UNIT- V

27 Signal transduction through protein tyrosin kinases

28 Receptors as pharmaceutical targets

29 Non receptor mediated drug action

30 Recent concepts and advances in receptors.

VPT-702 AUTACOID PHARMACOLOGY 1+0=1

Theory

UNIT I

1 Introduction to autacoid pharmacology

2 Histamine- synthesis , storage and destruction3 Pharmacological action of histamine ( Histamine receptors )4 Pathophysiological role of histamine5 Antihistamines- classification along with examples and its pharmacology6 ..do.. UNIT II

7 Pharmacodynamics of serotonin and its antagonists- synthesis , chemistry

and pharmacological actions.8 Eicosanoids, Bradykinin ,angiostensin, rennin-angiostensin system

9 Kallikrein and other kinins.

10 Prostaglandin, pathophysiology of inflammation.

11 Leucotriene and antileucotriene.

UNIT III

12 Platelate activating factof (PAF)- chemistry, biosynthesis, pharmacology ,

physiological role and its antagonists.

13 Slow reacting substance of anaphylaxisUNIT IV

14 Putative neurohumoral transmitters

15 Purine nucleotides, peptides16 Amino acid and nitric oxide.

17 Recent developments and advances in autacoids by referring selected

research articles from journals.

VPT-703 PHARMACOLOGY OF HERBAL DRUGS 2+1=3

Theory

UNIT I

1. Historical aspects of medicinal plants

2. Ancient literature on medical plants/herbs

3. Phytochemical constituents of important medicinal plants ,their definition and classification

4. Useful medicinal plants bioactive molecules used in therapeutics

UNIT II

5. Important bioactive molecules from medicinal plants

6. Identification , collections and preservations of medicinal plants

with pharmacologically active biomolecules

7. Isolation of pharmacologically active biomolecules with solvant

extraction and other procedures.

8. Screening procedure adopted for isolation of different fractions

from medicinal plants.

9. Procedures adopted for chemical identification of bioactive mol.

10. Clinical validation of bioactive molecule from medicinal plants/herbs

UNIT III

11. Characterization of pharmacological effects of potential herbal drug/

molecule.

12. Therapeutic utility of pharmacologically active molecule.

13. Toxicological studies of pharmacologically active fraction

UNIT IV

14. Strategies to be adopted for development of new herbal drug

15. Recent knowledge on biologically active molecule from latest

research literature.

Practicals

1. Extraction and isolation of plant material for separation of different phytochemicals by following different extraction procedures.

2. Methods of purification of biologically active fraction by TLC and HPLC

3. Pharmacological screening of isolated active molecules on following

a. Studies on intact lab animals

b. Studies on isolated tissues like heart, ilium, jejunum, rat uterus

rat fundus, atria etc.

c. Toxicity studies in lab. animals. LD50, short term toxicity studies

etc.

VPT-704 DRUG METABOLISM 2+0=2

Theory

UNIT I

1 Introduction to metabolism of drugs

2 Sites of biotransformation

3 Mechanism and process of drug metabolism

UNIT II

4 Synthetic pathways of drug metabolism with examples

5 ----------------- do ----------------------------

6 Non synthetic pathways of drug metabolism with examples

7 ----------------- do ----------------------------

UNIT III

8 Factors affecting drug biotransformation

9 Chemical and biological factors affecting drug biotransformation

10 Genetic and environmental factors affecting drug biotransformation

11 Species variation affecting biotransformation

UNIT IV

12 Hepatic microsomal enzyme system in biotransformation

13 Non microsomal enzyme system in biotransformation

14 P-450 micro oxygenase enzyme system

15 --------------do ------------------

16 Genetic polymorphism in metabolism of drugs.

UNIT V

17 Microsomal enzyme induction

18 Inhibition of drug metabolism

19 Consequences of microsomal enzyme induction

20 Metabolic drug interaction

VPT 705 MOLECULAR PHARMACOLOGY 2+0=2

Theory

UNIT I

1. Physicochemical properties of drugs

2. ..do..

3. Drug protein binding

4. Force involved in binding of drugs to receptors

UNIT II

5. Conformation and configuration of receptor

6. .do.

7. Structure activity relationship of receptor with examples

8. do

9. Application of structure activity relationship in new drug development

UNIT III

10. Theories of drug receptors interactions

11. ..do.

12. Dose response relationship analysis

13. Molecular mechanism of drug actions

14. ..do.

15. Specificity and selectivity of drug molecule to receptor

UNIT IV

16. Methods of identification of receptors

17. .do

18. Method of isolation of receptors

19. Characterization of receptors

20. Recent concepts and development in molecular pharmacology

VPT-706 PHARMACOKINETICS 2+1=3

Theory

UNIT 1

1. Routes of drug administration in animals.

2. Concepts of drug delivery system and its importance.

3. Absorption and distribution of drugs.

4. Biotransformation of drugs.

5. Elimination of drug.

6. Factors modifying drug delivery

UNIT II

7. Pharmacokinetics and its parameters.

8. Kinetics following single and multiple doses.

9. Different compartmental model in Pharmacokinetics studies.

10. Volume of distribution ,protein binding and drug distribution in pharmacokinetics.

11. Bioavailability factors and its clinical application.

12. ....do

UNIT III

13. Drug distribution and elimination.

14. Absorption and elimination half life.

15. Rate of transfer of drugs in different compartments.

16. Prolongation of drug action by different methods

UNIT 1V

17. Elimination kinetics (renal clearance, first order kinetics,zero order kinetic,plasma half life)

18. ..do..

19. Non-compartmental pharmacokinetic model.

UNIT V

20. Application of pharmacokinetic principle in therapeutics.

21. do.

22. Recent concepts and developments in pharmacokinetics

Practicals(706)

1. Determination of different pharmacokinetics parameters

2. ..do

3. Analysis of pharmacokinetics data

4. do

5. Bioavailability of drugs in normal subjects

6. ..do.

7. Bioavailability of drugs pharmacokinetics in diseased animals.

8. .do

VPT-707 PHARMACOGENOMICS

2+0=2

Theory

Unit 1

1. Introduction basic concepts, structure and functions of genes

2. Transcription, protein synthesis, stop codons, alleles

3. species / breed variation in drug response

4. increased and decreased response to drug effects

5. increased and decreased response to drug toxicities

6. Novel drug effects

Unit 2

1 Genetic polymorphism introduction, SNP

2 Canine and feline polymorphism

3 Types of genetic polymorphism with examples

4 Polymorphism in P 450

5 Polymorphism in G6 PD

6 Polymorphism in transporters

7 Clinical relevance of genetic polymorphism

8 Role of genes in multidrug resistance

Unit 3

13 Clinical situations requiring gene therapy personalized medicines

14 Gene transfer technology viral vectors

15 Gene transfer technology natural delivery strategies

Unit 4

16 Inherited diseases gene and drug therapy I

17 Inherited diseases gene and drug therapy II (asthma, schizophrenia, obesity)

18 Pharmacogenomics of cancer treatment

19 Genetic repair and inactivation strategies apoptasis I

20 Genetic repair and inactivation strategies apoptasis II

Unit 5

21 Gene libraries

22 Role of bioinformatics in pharmacogenomics I

23 Role of bioinformatics in pharmacogenomics II

24 Development of pharmacogenomics for application in animals

VPT-708 PHARMACOGENOMICS

2+0=2

Theory

Unit 1

1. General principles of immune response

2. Innate and adoptive immunity and their components,

3. Chemical mediators of immune system.

Unit 2

4. Pharmacological control of immune response (corticosteroids, Tacrolimus, cyclosporines, cyclophosphamides, Dapsone etc.).

5. Mechanism of immunostimulation and immunosupression, tolerogens

6. Hypersensitivity, anaphylaxis, immune mediated diseases

7. Immunostimulants Levamisole

Unit 3

8. Interrelation of nervous system, endocrine system and immune system

9. immunotoxic effects of environmental and other pollutants.

Unit 4

10. Xenobiotic induced immuno dysfunctions.

11. Immune deficiencies

12. Auto immune reactions

13. Therapeutic applications of immuno-regulant in asthma, arthritis.

14. Therapeutic applications of immuno-regulant in cancer.

15. Therapeutic applications of immuno-regulant in dermatology and organ transplant

VPT-709 Molecular Toxicology

2+0=2

Theory

Unit 1

1. Introduction to molecular toxicology

2. Cellular, subcellular and molecular toxicities

3. Mechanism of facilating and opposing distribution to target

4. Mechanism of toxicities

Unit 25. Factors affecting toxicities

6. Interaction of toxicants with target molecules (covalent /noncovalant bindings), enzyme reactions etc.

7. effects of toxicants on targets

Unit 3.

8. Toxic cell death Vs apoptosis

9. Normal repair mechanism for proteins, lipid DNA

10. Necrosis, fibrosis, carcinogenesis

11. Toxin induced dysregulation of gene expression and cellular activity

Unit 4.

12. Target organ directed toxicological effects (blood, liver, immune system,

13. Target organ directed toxicological effects (Kidney, respiratory system, Nervous system,.

14. Target organ directed toxicological effects (Ocular, olfactory system,.

15. Target organ directed toxicological effects (Cardiovascular system,.

16. Target organ directed toxicological effects (Skin).

17. Target organ directed toxicological effects (reproductive system),.

18. Target organ directed toxicological effects (endocrine system.).

19. Detoxification

20. Risk assessment of xenobiotics

Unit 4.

21. Chemical mutagens

22. Chemical Carcinogens

23. Chemical Teratogens

24. Radiation toxicity

25. Recent advances in molecular toxicology

VPT-710 Clinical Pharmacology

1+1=2

Theory

Unit 1

1. Introduction to Clinical Pharmacology

2. Veterinary Clinical Pharmacology : special features

3. Scope of clinical Pharmacology.

Unit I1

4. High throughput screening

5. Drug discovery --- Preclinical Pharmacological testing

6. Drug discovery --- Preclinical Toxicological testing

7. Phases of clinical trials

8. Post marketing surveillance and post marketing studies

9. Pharmacovigilance

10. Pharmacoepidemiology

11. Pharmacoeconomics.

Unit II1

12. Pharmacokinetics-Pharmacodynamics relationship and its applications

13. Drug interactions

14. ADR types

Unit IV

15. TDM

16. Drug regulations, rules and acts

VPT-710 Clinical Pharmacology

1+1=2

Practical

1. Plasma drugs levels in disease conditions

2. Pharmacokinetics in diseased animals

3. Doses adjustments in hepatic dysfunctions

4. Doses adjustments in kidney dysfunctions

5. Doses adjustments in neonates

6. Doses adjustments in pregnancy

7. Various protocols in clinical trials

VPT-711 Clinical Toxicology

2+1=3

Theory

Unit 1

1. Scope of clinical toxicology

2. Investigations / diagnosis of toxicities

3. Management of poisoning I clinical aspect pet and farm animals

4. Management of poisoning II Regulatory and forensic aspect

5. Prognostic indicators

Unit I1

6. Clinical and laboratory diagnosis of target organ toxicity integrated approach



9. Antidotal mechanism

Unit II1

10. Clinical Toxicology of heavy metals and minerals Arsenic,

11. Clinical Toxicology of heavy metals and minerals Lead,

12. Clinical Toxicology of heavy metals and minerals Copper

13. Clinical Toxicology of heavy metals and minerals Fluorine

14. Clinical Toxicology of heavy metals and minerals Selenium.

15. Clinical Toxicology of heavy metals and minerals Cadmium,.

16. Clinical Toxicology of heavy metals and minerals Mercury, Phosphorus.

17. Biomarkers of various heavy metal toxicities

18. Classification of pesticides, molecular mechanism of toxicities

19. Organophosphate, Organochlorine, Carbamate

20. Rodenticides, herbicides.

21. Animal poisons

22. Venoms- therapeutic management of bite and stings

23. Bacterial toxins and the their treatment of poisoning

24. Mycotoxins their effect on livestock, prevention and treatment

25. Toxic effect of solvents, vapors and their clinical management

26. Drug toxicities and their treatment

27. Feed additives : Toxicity and treatment

Unit IV28. Role of veterinary an forensic sciences

29. Aid of forensic and analytical toxicology in clinical diagnosis

30. Recent advances in clinical toxicology

VPT-711 Clinical Toxicology

2+1=3

Practicals

1. Induction of poisoning and antidotal treatment in lab animals.

2. Botanical and Zoological biomarkets of toxicities

3. Visit to GLP laboratory

4. Analysis of poison in biological samples and various spot tests

Lecture Schedule

VPT 712 ECOTOXICOLOGY 2+0=2

Unit I

1) Introduction to Ecotoxicology , Role of Veterinarians in ecotoxicology

2) Ecotoxicology and Animal Health

3) Sources of environmental pollutants

4) Effect of pollutants on eco health

Unit II

5) Air pollution history

6 )Indoor and outdoor sources of air pollution

7) Short term and long term effects of air pollution

8) Study of common air pollutants ( Industrial /agrochemical/ photochemical) I

9) Study of common air pollutants ( Industrial /agrochemical/ photochemical) II

10) Sources of water pollution

11) Chemical transportation between air water soil phases

12) Study of common water contaminants

13) Sources of soil contamination

14) Soil fauna and its role in eco system

15) Effects of various chemicals on soil parameters

16) Study of common soil contaminants

17) Fate of chemicals in environment and target species

Unit III

18) Terrestrial and aquatic ecotoxicology

19) Marine fauna as the biomarker of environmental toxicity

20) Wild life as the monitor of environmental qulity

Unit IV

21) Measures for reducing air pollution

22) Water treatments for purification cost benefit ratio

23) Safe chemical disposal Rules, regulations

24) Measure of pollution level

VPT 713

REGULATORY TOXICOLOGY 2+1

Unit I

1) Introduction to subject Role of veterinarian in regulatory toxicology

2) Toxicological risk assessment program principles

3) Interrelation between regulatory, mechnistic and descriptive toxicology

4) Different guidelines OECD, EPA, Indian pesticide Board ,Y schedule

5) OECD mandates and constitution

6) Role of regulatory bodies , global scenario

7) National Regulatory bodies and indian scenario

Unit II

8) Interaction between Toxicology and Industry

9) Indian drug industry

10) Indian Pesticide industry

11) Requirements , rules , regulations for pesticide registration

12) Compounds under regulatory legislation demand

13) Regulations for nurtraceuticals and herbals

14) Residue monitoring programs

15) Regulatory essential dose levels in chemical risk NOEL, NOAEL

16) LOEL, LOAEL, AOEL

Unit III

17) Risk assessment in practice

18) Classification of chemicals

19) Surveillance of chemicals

20) Exposure assessment Estimating MRLs, ADIs

21) Safety Pharmacology

Unit IV

22) GLP and its components

23) GLP certification

24) GLP in India

25) GMP

26) CPCSEA and animal welfare

Practicals VPT 713

1)Acute Toxicity in rodents

2) Acute toxicity in poultry

3) Oral subacute toxicity studies in rodents

4) Dermal subacute toxicity in rodents

5) Teratogenicity testing in rats

6) Dermal irritation test

7) Eye irritation test

8) Genotoicity and mutanenicity tests ( Ames test, chromosomal aberrations, Micronucleus test)

9) Visit to GLP lab

10) Models for carcinogenicity assessment

11) Lab animal toxicity data interpretations ,

MINUTES OF MEETING OF BOARD OF STUDIES IN

VETERINARY PHARMACOLOGY & TOXICOLOGY

XIII meeting of Board of Studies in Veterinary Pharmacology & Toxicology was held in the department of Veterinary Pharmacology & Toxicology, Nagpur Veterinary College, Nagpur at 10:00 hrs on date 30/10/2009.

Following members were present for the meeting..

1. Dr. C. R. Jangade

Professor of Pharmacology & Toxicology,

Nagpur Vet. College Nagpur.

Chairman

2. Dr. M. I. Qureshi


COVAS, Parbhani

3. Dr. P. R. More


KNP College of Veterinary Sciences, Shirwal,

4. Dr. Mrs. M. M. Gatne,


Bombay Veterinary College, Mumbai

5. Dr. A. P. Somkuwar


Udgir Veterinary College, Udgir.

6. Dr. A. A. Deshmukh.

Associate Professor of Pharmacology & Toxicology,

Udgir Veterinary College, Udgir.

7. Dr. Limse R. P.

Asst. Professor of Pharmacology & Toxicology,

Nagpur Vet. College Nagpur. Invitee8. Dr. Miss. Alka Satarkar


Nagpur Vet. College Nagpur. Invitee9. Dr Miss Awasthi


Nagpur Vet. College Nagpur. Invitee10. Dr. S.R. Rajurkar

Associate Professor of Pharmacology & Toxicology,

COVAS, Parbhani

Secretary

Atthe onset chairman welcomed all the members and thereafter the meeting started as per agenda.

Agenda No. 1 Approval of the Proceedings of last meeting :

Proceedings of last meeting were read out and confirmed unanimously by the members of the house.

Agenda No. 2 Discussion and preparation of lecture and practical schedule for M. V. Sc. courses in Vet. Pharmacology & Toxicology.

The contents of the courses ..

VPT 601 GENERAL PHARMACOLOGY

2+0

VPT 602 AUTONOMIC AND AUTACOID PHARMACOLOGY

2+1

VPT 603 CNS PHARMACOLOGY

2+1

VPT 604 DIGESTIVE AND RESPIRATORY PHARMACOLOGY 2+0

VPT 605 CARDIOVASCULAR AND RENAL PHARMACOLOGY 2+0

VPT 606 ENDOCRINE AND REPRODUCTIVE PHARMACOLOGY 2+0

VPT 607 CHEMOTHERAPY

2+1

VPT 608 TOXICOLOGY OF XENOBIOTICS

2+1

VPT 609 TOXICOLOGY OF PLANTS AND TOXINS

2+0

VPT 610 PHARMACOLOGICAL TECHNIQUES

1+1

VPT 611 TECHNIQUES IN TOXICOLOGY

1+1

VPT 612 ETHNOPHARMACOLOGY

2+0

VPT 691 MASTERS SEMINAR

1+0

VPT 699 MASTERS RESEARCH

20

were discussed course wise for the common academic regulations course curricula and syllabi for PG education in Agricultural and allied sciences as per the guidelines of ICAR.

Accordingly the lecture schedule of theory and practical were prepared, discussed and finally approved unanimously along with semester wise break up of courses (copy of lecture and practical schedule and break up of courses is enclosed --- Annexure I ).

During discussion it was observed that master seminar course VPT 691 has been given credit as 1 + 0 = 1. After thorough discussion it was unanimously decided that the credit load should be 0 + 1=1 as this course do not involve any theory and also mid term examination. Therefore the credit load of Master Seminar VPT 691 has been changed as 0 + 1=1 without changing the title and credit load of the course.

RESOLUTION 04/09

The lecture schedule of theory and practical for M. V. Sc. courses were approved unanimously on date 30/10/2009 ( Annexure I ).

Agenda No. 3 Discussion and preparation of lecture and practical schedule for Ph. D. courses in Vet. Pharmacology & Toxicology.

The contents of the courses

VPT 701 ADVANCES IN NEUROPHARMACOLOGY

2+0

VPT 702 AUTACOID PHARMACOLOGY

1+0

VPT 703 PHARMACOLOGY OF HERBAL DRUGS

2+1

VPT 704 DRUG METABOLISM

2+0

VPT 705 MOLECULAR PHARMACOLOGY

2+0

VPT 706 PHARMACOKINETICS

2+1

VPT 707 PHARMACOGENOMICS

2+0

VPT 708 IMMUNOPHARMACOLOGY

1+0

VPT 709 MOLECULAR TOXICOLOGY

2+0

VPT 710 CLINICAL PHARMACOLOGY

1+1

VPT 711 CLINICAL TOXICOLOGY

2+1

VPT 712 ECOTOXICOLOGY

2+0

VPT 713 REGULATORY TOXICOLOGY

2+1

VPT 790 SPECIAL PROBLEM

0+2

VPT 791 DOCTORAL SEMINAR I

1+0

VPT 792 DOCTORAL SEMINAR II

1+0

VPT 799 DOCTORAL RESEARCH

45

were discussed course wise for the common academic regulations course curricula and syllabi for PG education in Agricultural and allied sciences as per the guidelines of ICAR.

Accordingly the lecture schedule of theory and practical were prepared, discussed and finally approved unanimously along with semester wise break up of courses (copy of lecture and practical schedule and break up of courses is enclosed --- Annexure II ).

During discussion it was observed that course VPT 701 ( 2+0=2) has been given title as ADVANCES IN NEUROPHARMACOLOGY after going through the contents of the course it was observed that the contents do not match appropriately with the title. Keeping the contents and credits as it is and without any change it was suggested by the members of the Board of studies to modify its title as ADVANCES IN PHARMACODYNAMICS.

Accordingly the title of the course VPT 701 is modified as ADVANCES IN PHARMACODYNAMICS. Credits 2 + 0 =2 instead of ADVANCES IN NEUROPHARMACOLOGY.

House unanimously approved the modifications and was passed unanimously.

Similarly VPT 791 Doctoral Seminar I and VPT 792 Doctoral Seminar II has been given credit load as 1 + 0 = 1 respectively.

After thorough discussion it was unanimously decided that the credit load should be 0 + 1=1 for each course (VPT 791 and VPT 792) as these courses do not involve any theory and also mid term examinations. Therefore the credit load of Doctoral Seminar I, VPT 791 and Doctoral Seminar II, VPT 792 has been changed as 0 + 1=1 respectively without changing the title and credit load of these courses.

Further it was suggested by all the members of the house that the courses of Ph. D. should not be fixed (Core courses). However, liberty should be given to choose the courses from VPT 701 to VPT 713 keeping intact the total credit load allocated to different semesters this will enable to cover all the courses mentioned in the guidelines and can be given the related courses to Ph. D. students according to the nature of research work to be carried out.

This suggestion was accepted by the house unanimously with request to consider it.

RESOLUTION 05/09

The lecture schedule of theory and practical for Ph. D. courses were approved unanimously on date 30/10/2009 ( Annexure II ).

Agenda No. 4 Approval of the ORW of Ph. D. Student :

ORW of Ph. D. Student Mr. Salve Pradip Buwaji Enrolment No. V/02/338, Ph. D. Scholar from Department of Veterinary Pharmacology & Toxicology, College of Veterinary & Animal Sciences, Parbhani was discussed in depth and after discussion it was approved unanimously by the house with suggestion.

Name of studentCollegeTitle of ORWRemarks / Suggestion

Salve Pradip Buwaji COVAS, ParbhaniComparative Evaluation of Phyllanthus emblica and Allium sativum on arsenic induced genotoxicity, oxidative stress and Immunotoxicity in mice and ratsIAEC approval required

RESOLUTION 06/09

The ORW of Ph. D. student Mr. Salve Pradip Buwaji is approved unanimously on date 30/10/2009.

Agenda No. 5 Any other point with the permission of chair :

The members of BOS congratulated Dr C R Jangade for bestowing the responsibility of Associate Dean, NVC, Nagpur in addition to his own duties.

It was also decided unanimously to change the place of BOS for the forth coming meetings for which all the members agreed unanimously.

The meeting ended with the vote of thanks to the chair.

Dr. C. R. Jangade

Dr. S.R. Rajurkar

Chairman

Secretary

19Dr.Dahiphale Hanumant

Documents

PG VCI Syllabus3010.doc