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Pediatric Cardiology 2016 Annual Report
Division Introduction
The Pediatric Cardiology Division provides comprehensive care for children with heart disease, conducts seminal research, and oversees a nationally recognized training program.
Under the direction of Gerald Greil, M.D., Ph.D., the Division provides services at Children’s Medical Center Dallas and Children’s Medical Center Plano in:
• Outpatient clinics (~12,000 visits/year) • A 22-bed inpatient telemetry floor dedicated to cardiac patients • A 32-bed dedicated Cardiac Intensive Care Unit • Two catheterization laboratories for diagnostic and interventional
procedures, including catheter ablation • A 1.5T cardiac MRI scanner fully dedicated to Pediatric Cardiac Imaging with
and without general anesthesia. The close proximity of this scanner to the cardiac catheterization laboratory allows combined MRI – cardiac catheterization procedures (XMRI).
• All imaging facilities are in close proximity to the OR allowing intra- and perioperative assessment of surgical and cardiac catheterization procedures.
• An echocardiography suite, including special areas for fetal echocardiography, as well as a complete non-invasive monitoring laboratory
• Outreach services are available at multiple sites throughout North Texas
Faculty
The Division has 27 board-certified pediatric cardiologists, each with a special area of expertise, including critical care medicine, interventional catheterization, electrophysiology, advanced imaging including echocardiography and fetal echocardiography, cardiac Magnetic Resonance Imaging (MRI) and Computed Tomography (CT), fetal cardiology, cardiac transplantation, heart failure, prevention, and adults with congenital heart disease.
Three new faculty members joined the Pediatric Cardiology team in 2016. Ryan J. Butts, M.D. Assistant Professor
B.A., B.S., magna cum laude College of Charleston, Charleston, SC, 2001 M.D. Medical University of South Carolina, Charleston, SC, 2005 Postdoctoral Training Residency, Pediatrics Baylor College of Medicine, Houston, TX, 2005-2008 Fellowship, Pediatric Cardiology Medical University of South Carolina, Charleston, SC, 2008-2011 Interests Heart failure in single ventricle patients, outcomes after pediatric heart transplantation, pediatric heart failure
Gerald Greil, M.D., Ph.D. Professor, Division Chief
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Pediatric Cardiology 2016 Annual Report
C. Richard Kirk, M.A., FRCP, FRCOCH Professor
B.A. Cambridge University, Cambridge, UK, 1976 M.B. Christ's College, Cambridge University, Cambridge, UK, 1979 Guy’s Hospital, London, UK, 1979 Postdoctoral Training Residency, General Surgery Guy’s Hospital, Great Maze Pond, London, UK, 1979-1980 Residency, General Medicine Pembury Hospital, Tunbridge Wells, Kent, UK, 1980 Chief Residency, Pediatrics Kettering General Hospital, Kettering, UK, 1981 Chief Residency, Pediatrics Bristol Royal Hospital for Children, Bristol, UK, 1982-1983 Fellowship, Pediatrics Alder Hey Children’s Hospital, Liverpool, UK, 1986-1987 Fellowship, Cardiothoracic Medicine Harefield Hospital, Hill End Road, Harefield, Middlesex, UK, 1987-1989 Fellowship, Pediatric Cardiology Freeman Hospital, High Heaton, Newcastle upon Tyne, UK, 1989-1990 Visiting Fellowship, Pediatric Cardiology (only a month long) Harvard Medical School/Children’s Hospital Boston, Boston, MA, 1990 Visiting Fellowship, Pediatric Cardiology (only a month long) Children’s Hospital, University of California, San Francisco, CA, 1990 Interests Heart failure and transplantation
David L. Sutcliffe, M.D. Assistant Professor
B.S. Texas A&M University, College Station, TX, 2001 M.D. UT Southwestern Medical School, Dallas, TX, 2008 Postdoctoral Training Residency, Pediatrics UT Southwestern Medical Center/Children’s Health, Dallas, TX, 2008-2011 Chief Residency, Pediatrics UT Southwestern Medical Center/Children’s Health, Dallas, TX, 2011-2012 Fellowship, Pediatric Cardiology UT Southwestern Medical Center/Children’s Health, Dallas, TX, 2012-2015 Fellowship, Pediatric Heart Failure/Transplant Harvard Medical School/Children’s Hospital Boston, Boston, MA, 2015-2016 Interests Heart failure, ventricular assist devices, cardiac transplantation
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Pediatric Cardiology 2016 Annual Report
Honors / Awards Maria Bano
• Promotion to Assistant Professor
Ryan Butts
• Mitchell I Rubin Research Award, Medical University of South Carolina Department of Pediatrics
Tarique Hussain
• Awarded funding from NuMED for Children’s, LLC for research on Modified CP Stent with variable cell dimensions
David Sutcliffe
• Kane/Owens Award for Compassionate Care, Children’s Hospital Boston
Animesh Tandon
• Early Research Career Award, Thrasher Foundation • Early Career Research Award, Children’s Clinical Research Advisory Committee (CCRAC)
Surendranath Veeram Reddy
• Promotion to Associate Professor
Best Pediatric Specialists in Dallas, D Magazine
• Vivian Dimas • Lynn Mahony • Claudio Ramaciotti • William Scott • Thomas Zellers
Texas Super Doctors, Texas Monthly Magazine
• Adrian Dyer • Matthew Lemler • Lynn Mahony • Alan Nugent • Claudio Ramaciotti • William Scott • Surendranath Veeram Reddy
Invited Lectures
Ryan Butts
• Panelist, 2016 American Heart Association Scientific Sessions, New Orleans, LA, November 2016 o “Pediatric Mechanical Circulatory Support Simulation”
Vivian Dimas
• SCAI Scientific Sessions Annual Meeting, Orlando, FL, May 2016 o “Congenital Scanning: Beyond Structure and Function”
• SCAI Fall Fellows Course, Session 2: Diagnostic Catheterization in Congenital Heart Disease, Las Vegas, NV, December 2016
o “Basic Hemodynamic Assessment: Waveforms, Shunt Calculations and Cardiac Output Assessment”
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Pediatric Cardiology 2016 Annual Report
Gerald Greil
• Moderator, Session 4, Society for Cardiovascular Magnetic Resonance, Los Angeles, January 2016 o “Congenital Scanning: Beyond Structure and Function”
• Association for European Paediatric and Congenital Cardiology, 50th Annual Meeting, Rome, Italy, June 2016 o “ECHO is the Best Non-invasive Imaging Tool We Have for Monitoring Patients with Kawasaki Disease!
Against Rebuttal” • 14th SPR Hands-On Course on Pediatric Cardiovascular MR, Houston, TX, October 2016
o “MR protocol for ventricular function” o “Hands-on post-processing” o “Interactive MR scanning”
• 12th SPR Advanced Symposium on Cardiovascular Imaging, Houston, TX, October 2016 o “Work in Progress – Dallas” o Moderator, ”Clinical Imaging Update 2: Coronary Imaging”
Mohammed Hussain
• Society for Cardiovascular Magnetic Resonance Annual Scientific Meeting, Los Angeles, January 2016 o “Vessel Wall Imaging & Vascular Function: Fad or Future?”
Conference Presentations
Byrne N, Velasco Forte MDLN, Narayan S, Tandon A, Greil GF, Valverde I, Hussain T.
Poster, Society for Cardiovascular Magnetic Resonance (SCMR) Scientific Sessions, Los Angeles, CA, January 2016 “Steps Towards an Automated 3D Printing Pipeline in Congenital Heart Disease”
Byrne N, Velasco Forte MDLN, Narayan S, Tandon A, Greil GF, Valverde I, Hussain T.
Poster, Mimics Innovation Conference, Tampa, FL, February 2016 “Steps Towards an Automated 3D Printing Pipeline in Congenital Heart Disease”
Gambetta K, Butts RJ, Boyle GJ, Knecth KR, Law Y, Prada-Ruiz CA, Richmond ME, West SC, Lal AK, Deshepande SR.
Poster, Mimics Innovation Conference, Tampa, FL, February 2016 “Pediatric Acute Myocarditis in a Contemporary Multi-Center Cohort”
Velasco Forte MDLN, Byrne N, Tandon A, Bell A, Hussain T.
Poster, Mimics Innovation Conference, Tampa, FL, February 2016 “3D Printed Models for Complex Heart Diseases: Assessment in Coronary Fistula”
Bano M, Das B.
Poster, International Society for Heart and Lung Transplantation Meeting, Washington, DC, April 2016 “15 Year Old Female Presenting with Hemiplegia Seven Years after Heart Transplantation”
Butts RJ, Boyle GJ, Deshepande SR, Gambetta K, Knecth KR, Law Y, Prada-Ruiz CA, Richmond ME, West SC, Lal AK.
Poster, International Society for Heart and Lung Transplantation Meeting, Washington, DC, April 2016 “Pediatric Acute Myocarditis in a Contemporary Multi-Center Cohort”
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Pediatric Cardiology 2016 Annual Report
Knecth KR, Butts RJ, Boyle GJ, Deshepande SR, Gambetta K, Law Y, Richmond ME, Lal AK, West SC, Prada-Ruiz CA.
Oral, International Society for Heart and Lung Transplantation Meeting, Washington, DC, April 2016 “Risk Factors for Heart Failure Readmission after Pediatric Myocarditis”
Richmond ME, Butts RJ, Boyle GJ, Deshepande SR, Gambetta K, Knecth KR, Law Y, Prada-Ruiz CA, Lal AK, West SC.
Oral, International Society for Heart and Lung Transplantation Meeting, Washington, DC, April 2016 “Risk Factors for Poor Outcomes in Pediatric Myocarditis”
Snarr B, Dyer A, Thankavel P.
Poster, American College of Cardiology Scientific Sessions, Chicago, IL, April 2016 “Diagnosing Vascular Rings: Evaluation of Imaging Modalities”
Webb MK, Dyer AK, Hussain T, Reddy S, Zellers TM, Nugent AW, Forbess JM, Dimas VV.
Oral, Society for Cardiac Angiography and Interventions Scientific Sessions, Orlando, FL, May 2016 “Successful Hybrid Valve Sparing Repair of TOF with Intervention Free Follow Up To 2 Years”
Tandon A, Dyer AK, Byrne N, Velasco Forte MDLN, Dillenbeck JM, Greil GF, Hussain T.
Moderated Oral Poster, Association for European Paediatric and Congenital Cardiology, 50th Annual Meeting, Rome, Italy, June 2016 “Use of a Semi-automated Cardiac Segmentation Tool Improves Reproducibility and Speed of Segmentation of Contaminated MRA Datasets”
Welch T, Souza D, Nugent AW.
Poster, Biomedical Engineering Society, Minneapolis, MN, October 2016 “Poly-L-Lactide Fiber Mechanical Properties and Degradation for Bioresorbable Stents”
Schumacher K, Yu S, Lowery R, Butts R, Castleberry C, Chen S, Edens E, Godown J, Johnson J, Kemma M, Lin K, Simpson K, West S, Wilmot I, Gossett J.
Oral, AHA Scientific Sessions, New Orleans, LA, November 2016 “The Influence of Fontan-associated Protein-losing Enteropathy on Outcomes in Patients Referred for Heart Transplant: a Multicenter Study”
Selected Chairs
Gerald Greil
• Chairperson – Scientific Session: Working Group Symposium: Imaging, Pulmonary Hypertension and Heart Failure, Genetics and Basic Science, Cardiac Dysrhythmias and Electrophysiology, 50th Annual Association for European Paediatric and Congenital Cardiology (AEPC), Rome, Italy, June 2016
o “Risk Stratification in Hypertrophic Cardiomyopathy”
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Pediatric Cardiology 2016 Annual Report
Education and Training
The Division is dedicated to the training of medical students, residents, and fellows.
Medical Students
• Third-Year Pediatric Rotations: o Cardiology inpatient rotations with three medical
students throughout the year o Pediatric Cardiology Clinic Days
• Fourth-Year Electives in Pediatric Cardiology: o Cardiac Outpatient Clinic Rotation o Cardiac Intensive Care Unit Rotation o Cardiac Imaging Rotation (MRI, CT, echocardiography)
Residents
The Division of Pediatric Cardiology plays a major role in the training of pediatric residents. Training occurs at many levels.
• Inpatient Training: o Three interns and one senior resident typically participate on the cardiology inpatient service, caring for
patients on a 22-bed cardiology floor with the supervision of the attending cardiologist o An elective is available for residents to rotate in the Cardiac Intensive Care Unit
• Outpatient Training: o One or two second- or third-year residents are typically training in the Cardiology Outpatient Clinic under
the supervision of the attending cardiologists
Fellows
The Pediatric Cardiology fellowship currently accepts two trainees per year in the categorical program, and advanced training is available in cardiac critical care, catheterization/intervention, advanced imaging, and cardiac transplantation. The program provides fellows the training, tools, and philosophy necessary for advancing the field of pediatric cardiology within their areas of choice.
Fellows rotate through all subspecialty areas of cardiology. They also spend one year participating in prospective clinical, translational, or basic science research.
Two new fellows are recruited each year in the three-year Pediatric Cardiology Fellowship Program. Many fellows choose to complete a fourth year to pursue a specialized clinical interest. All pediatric cardiology faculty members are actively involved in the fellows’ training.
In addition to the standard three-year fellowship program, qualified fellows are offered an additional fourth-year training programs in cardiac critical care, interventional cardiology, advanced cardiac imaging, electrophysiology, heart transplantation, preventive cardiology, prospective clinical research, and basic research. The structure of these experiences depends on the interests and skills of the individual fellow.
Dr. Melissa Webb, Fellow
Dr. Colin Kane rounding with medical students and residents
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Pediatric Cardiology 2016 Annual Report
Research Activities
Members of the Division of Pediatric Cardiology are engaged in multiple research projects to advance the care of children with heart disease.
Basic Science
An exciting new area of investigation is the development of biodegradable stents for use in the cardiovascular system. Current research is directed at an evaluation of the tissue response to these materials in animals. Cardiopulmonary bypass is known to have adverse effects on neurologic development, but a clear understanding of the mechanisms is lacking. Using a mouse model of bypass, investigation is underway to evaluate biomarkers of injury.
Another new area of investigation is to optimizer cardiovascular support therapy for pediatric patients with end stage heart failure. Currently the only ventricular assist devices available require surgical placement. Researchers are investigating in an animal model the feasibility of a catheter delivered devise. One additional animal research area is the optimization of technologies for fetal intervention.
In close cooperation with the Department of Radiology faculty have access to the Advanced Imaging Research Center at UT Southwestern. This gives staff members access
to novel cardiovascular research technology to contribute to existing research as well as opportunity to design their individual research projects.
Clinical Sciences
The Pediatric Cardiology Division participates in multiple multicenter trials. In interventional catheterization, current trials are assessing various devices, including the Amplatzer and Helex occluders, and management of coarctation, including the placement of stents. It is anticipated that a recently completed multicenter trial of athletic screening processes will be used for a broader national evaluation.
The Division is contributing to a quality initiative to assess the care of patients with hypoplastic left heart syndrome. A multicenter effort is also underway to evaluate the use of ventricular assist devices in the pediatric population.
Collaborative studies within the Department of Pediatrics include protocols to evaluate stroke, migraine, and complications of sickle cell disease and childhood cancer.
Ongoing areas of research interest include epidemiologic studies of congenital heart disease, particularly within the state of Texas, natural history studies of patent ductus arteriosus in pre term neonates; evaluation of renal function with heart catheterization, markers for cardiac transplant rejection, development of new techniques for pediatric cardiovascular MRI; 3D printing and modeling of congenital heart disease; and using cutting-edge wearable sensors, combined with innovative big data techniques, to improve monitoring of children with heart disease while at home.
Drs. Catherine Ikemba and Kavita Sharma
A 3D printed heart model of a patient with situs inversus and double outlet
right ventricle after surgical repair.
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Pediatric Cardiology 2016 Annual Report
Clinical Activities
The Pediatric Cardiology division offers a comprehensive program of specialized care at the Heart Center at Children’s Health℠ for children with congenital and acquired heart diseases, and children who have grown into adults with congenital heart disease. The Heart Center's team of professionals includes cardiologists, cardiac surgeons, cardiac intensivists, neonatologists, and cardiac anesthesiologists. In addition to providing the highest quality clinical and surgical care, our faculty members are committed to improving the health of children everywhere by sharing innovations and research.
Inpatient Services
Inpatient service is divided between the cardiac intensive care unit and the cardiology inpatient floor, on which all beds have telemetry capability with central monitoring. The inpatient floor functions as a “step-down” unit with the capacity to manage higher acuity patients, including those with temporary pacemakers and vasoactive infusions. There are usually 20 patients in the cardiac intensive care unit and 20 patients on the cardiology floor. New consultations average three to five per day.
Outpatient Services
Approximately 12,000 cardiology outpatients are seen each year at the Heart Center and regional outreach clinics. Subspecialty cardiology clinics, including heart transplantation, heart failure, arrhythmia, pacemaker, preventive cardiology, and young adult congenital heart disease, are held on a weekly or monthly basis.
Preventive Cardiology Clinic
A preventive cardiology clinic serves children with hyperlipidemia and hypercholesterolemia and children with metabolic syndrome (i.e. obesity, insulin resistance, increased triglycerides, decreased high density lipoprotein, and hypertension). A team of physicians, dietitians, and nurses provides comprehensive physical assessments and dietary evaluations for patients and their families, with the development of individualized programs, including:
• Diet • Life style modification • Treatments, including natural as well as prescription medications
Pediatric Echocardiography Laboratory
The pediatric echocardiography laboratory at Children’s Health is Intersocietal Accreditation Commission (IAC) accredited for pediatric transthoracic, transesophageal, and fetal echocardiography. Six dedicated sub-specialty trained physicians staff the laboratory and provide coverage 24/7. The team consists of highly trained pediatric sonographers who perform approximately 11,000 studies a year and provides direct services for 4 primary hospitals and 2 outpatient sites. In addition, we provide support services for tele-echocardiography at 3 additional hospitals and 4 outreach clinics.
Drs. David Fixler and Gerald Greil
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Pediatric Cardiology 2016 Annual Report
The laboratory offers the latest technology including fetal echocardiography, stress imaging, 3 dimensional and strain imaging and provides imaging support for the cardiac operating rooms, ECMO cannulation, and catheterization laboratory.
The fetal heart program is Joint Commission Disease Specific Certified. We perform between four and five hundred fetal echocardiograms and consultations a year. The program expertly coordinates prenatal testing and delivery planning to ensure critical congenital heart conditions receive the care they need at precisely the right time. Comprehensive multidisciplinary consultations may include an imaging cardiologist, electrophysiology cardiologist and nurse, cardiothoracic surgeon, social work, neurodevelopmental specialist, and introduction to our “safe at home”
program for interstage single ventricle monitoring program. We also participate in multi-institutional studies investigating rare congenital heart disease that can be detected in utero.
The laboratory has a strong track record of academic endeavors, including research on congenital coronary artery imaging, identification of rejection in transplanted hearts, and evaluation of single ventricle palliation. We have many successful research collaborations with other divisions in pediatrics including neonatology, hematology/oncology and neurology. We have recently participated in a multi-center National Institute of Health (NIH) funded study to determine normal values for pediatric echocardiography.
2015 Patient Statistics
Children’s Medical Center Dallas New outpatient visits
Total 2,985 7,916
Inpatient admissions 898 CATH procedures 741 ECHO volume 8,840
Cardiology at Children’s Legacy
New outpatient visits Total
1,444 2,770
ECHO volume 1,351
Cardiology at Children’s Southlake New outpatient visits
Total 232 411
ECHO volume 208 Cardiology at Outreach
New outpatient visits Total
620 1,015
ECHO volume 704 Telemedicine
ECHO 1,146 ECG 824 Holter 80
Dr. Suren Veeram Reddy with catheterization lab technician, Jamie King
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Pediatric Cardiology 2016 Annual Report
Current Grant Support
Ryan Butts
Grantor: American Heart Association Mentored Clinical Research Program Title of Project: Effect of Carvedilol on Exercise Performance in Fontan Patients Role: Principal Investigator Dates: 07/2016 - 07/2018
Gerald Greil
Grantor: Children’s Clinical Research Advisory Council (Children’s Health) Title of Project: 3D Printing of Patient Specific Congenital Heart Defects and Comparisons to Conventional Imaging Methods Role: Co-Investigator Dates: 02/2016 – 02/2018 Grantor: Association of European Cardiology (AEPC) Title of Project: 3D printing of congenital heart disease: hands-on imaging from fetal development to long term follow up Role: Co-Investigator Dates: 02/2016 – 02/2017 Grantor: NIHR Title of Project: MRI-augmented guidance for X-ray fluoroscopic pediatric cardiovascular interventions. Role: Principal Investigator Dates: 01/2015 – 12/2016
Grantor: Medical Research Foundation Title of Project: Accelerated 3D Cardiac Functional Assessment using Cardiac Self-gating and Under sampled Respiratory Motion Compensation Techniques. Role: Co-Investigator Dates: 05/2015 – 08/2016
Grantor: Technology Strategy Board (EPSRC) Title of Project: Atherosclerosis stratification using advanced imaging and computer-based models Role: Co-Investigator Dates: 01/2014 – 12/2016
Grantor: NIHR Title of Project: Healthcare Technology Co-operative: Cardiovascular Technologies Role: Co-Investigator Dates: 01/2013 – 12/2016
Tarique Hussain
Grantor: NuMED for Children, LLC Title of Project: Modified CP Stent with variable cell dimensions Role: Principal Investigator Dates: 02/2016 – ongoing
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Pediatric Cardiology 2016 Annual Report
Grantor: Children’s Clinical Research Advisory Council Title of Project: 3D Printing of Patient Specific Congenital Heart Defects and Comparisons to Conventional Imaging Methods Role: Principal Investigator/Scientific Mentor Dates: 02/2016 – 02/2018
Grantor: Action Medical Research Title of Project: Improving surgical decisions in hypoplastic left heart syndrome (HLHS) through computational cardiac models Role: Co-Investigator Dates: 09/2015 – 02/2019
Grantor: BHF PG/15/104/31913 Title of Project: How accurate are our clinical measures of aortic stiffness? A combined in vitro, in silico and in vivo study Role: Co-Investigator Dates: 02/2016 – 02/2019
Grantor: Association of European Cardiology Title of Project: 3D printing of congenital heart disease: hands-on imaging from fetal development to long term follow up Role: Co-Investigator Dates: 02/2016 – 02/2017
Grantor: NIHR Title of Project: Healthcare Technology Co-operative: Cardiovascular Technologies Role: Co-Investigator Dates: 01/2013 – 12/2016
Richard Kirk
Grantor: International Society of Transplantation Title of Project: International Pediatric Heart Failure Registry Role: Co-Investigator Dates: 2015 – 2018
Lynn Mahony
Grantor: National Heart, Lung and Blood Institute Title of Project: Pediatric Heart Disease Research Network Role: Steering Committee Chair Dates: 2011 – 2016
Grantor: Cincinnati Children’s Hospital Title of Project: Quality of Life Assessment in the Pediatric Cardiac Population: Testing the Pediatric Cardiac Quality of Life Inventory Role: Principle Investigator Dates: 2005 – ongoing
Grantor: SWAT Small Group Program Award Title of Project: Matters of the Heart: A New Ambulatory Pediatric Cardiology Curriculum Role: Principal Investigator Dates: 2015 – 2016
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Pediatric Cardiology 2016 Annual Report
Alan Nugent
Grantor: NIH Title of Project: Development of Large Diameter Biodegradable Stents for Congenital Heart Disease Role: Principal Investigator Dates: 07/2015 – 06/2017
Animesh Tandon
Grantor: Thrasher Foundation Title of Project: Predictive analytics to prevent adverse events in interstage single ventricle heart disease Role: Principal Investigator Dates: 02/2016 – 01/2018
Grantor: Children’s Clinical Research Advisory Committee (CCRAC) Title of Project: 3D Printing of Patient-Specific Congenital Heart Defects and Comparisons to Conventional Imaging Methods Role: Principal Investigator Dates: 02/2016 – 01/2018
Grantor: UT Southwestern Center for Translational Medicine Service Package Grant Title of Project: Cardiac Magnetic Resonance Imaging for Patients with High Cardiometabolic Risk Factors Role: Principal Investigator Dates: 11/2016 – 01/2017
Grantor: Texas Neurofibromatosis Foundation Grant Title of Project: Cardiovascular abnormalities in pediatric patients with neurofibromatosis type 1 Role: Co-Investigator Dates: 05/2016 – 05/2017
Surendranath Veeram Reddy
Grantor: American Heart Association SWA Beginning Grant-in-Aid. Lawrence J. and Florence A. De George Award Title of Project: Evaluation of a Novel Design Biodegradable Stent in Porcine Model of Aortic Coarctation Role: Principal Investigator Dates: 01/2015- 12/2016
Grantor: NIH Title of Project: Novel Design Biodegradable Stent for Treatment of Porcine Pulmonary Artery Stenosis Role: Co-Investigator; Principal Investigator Dates: 01/2015 – 12/2016
Grantor: Children’s Clinical Research Advisory Committee (CCRAC) Title of Project: 3D Printing of Patient-Specific Congenital Heart Defects and Comparisons to Conventional Imaging Methods Role: Co-Investigator Dates: 02/2016 – 02/2018
Ilana Zeltser
Grantor: NIH / Children’s Hospital of Philadelphia Title of Project: Hypertrophic Cardiomyopathy in Children: Age Specific Risk Stratification for Sudden Death Role: Co-Investigator Dates: 06/2014 – 06/2019
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Pediatric Cardiology 2016 Annual Report
Peer-Reviewed Publications
1. Bidhult S, Xanthis CG, Liljekvist LL, Greil G, et al. Validation of a new t2* algorithm and its uncertainty value for cardiac and liver iron load determination from MRI magnitude images. Magn Reson Med 2016;75:1717-29.
2. Butts RJ, Chowdhury SM, Baker GH, Bandisode V, Savage AJ, Atz AM. Effect of Sildenafil on Pressure-Volume Loop Measures of Ventricular Function in Fontan Patients. Pediatr Cardiol 2016;37:184-91.
3. Byrne N, Velasco Forte M, Tandon A, Valverde I, Hussain T. A systematic review of image segmentation methodology, used in the additive manufacture of patient-specific 3D printed models of the cardiovascular system. JRSM Cardiovascular Disease 2016;5:2048004016645467.
4. Chowdhury SM, Butts RJ, Taylor CL, et al. Validation of Noninvasive Measures of Left Ventricular Mechanics in Children: A Simultaneous Echocardiographic and Conductance Catheterization Study. Journal of the American Society of Echocardiography: Official Publication of the American Society of Echocardiography 2016;29:640-7.
5. Das BB, Koch J, Dimas V, Guleserian K, Nugent A. Use of nesiritide in critically ill children with biventricular dysfunction suffering from oliguria despite standard heart-failure management. Cardiol Young 2016;26:819-23.
6. Das BB, Prusty BK. Clinical Relevance of Detection of HHV-6 by PCR DNA Test in the Blood for Diagnosing Myocarditis. Pediatr Cardiol 2016;37:429-30.
7. Das BB, Rakheja D, Lacelle C, et al. Possible progesterone-induced gestational activation of chromosomally integrated human herpesvirus 6B and transplacental transmission of activated human herpesvirus 6B. J Heart Lung Transplant 2016 Nov;35(11):1373-1376.
8. Elhoff JJ, Chowdhury SM, Taylor CL, Hassid M, Savage AJ, Atz AM, Butts RJ. Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients. Pediatric Transplantation 2016 Dec;20(8):1106-1110.
9. Goodfriend AC, Welch TR, Nguyen KT, Johnson RF, Sebastian V, Reddy SV, Forbess J, Nugent A. Thermally processed polymeric microparticles for year-long delivery of dexamethasone. Mater Sci Eng C Mater Biol Appl 2016;58:595-600.
10. Greenway SC, Butts R, Naftel DC, et al. Statin therapy is not associated with improved outcomes after heart transplantation in children and adolescents. J Heart Lung Transplant 2016;35:457-65.
11. Greenway SC, Crossland DS, Hudson M, Martin SR, Myers RP, Prieur T, Hasan A, Kirk R. Fontan-associated liver disease: Implications for heart transplantation. J Heart Lung Transplant 2016;35:26-33.
12. Henningsson M, Hussain T, Vieira MS, Greil GF, et al. Whole-heart coronary MR angiography using image-based navigation for the detection of coronary anomalies in adult patients with congenital heart disease. J Magn Reson Imaging 2016;43:947-55.
13. Herbert CE, Reddy SR, Lemler MS. Use of Amplatzer Vascular Plugs for the treatment of combined extralobar and intralobar pulmonary sequestration in a 5-year-old child. Cardiol Young 2016;26:1441-4.
14. Herbert CE, Veeram Reddy S, Welch TR, Wang J, Richardson JA, Forbess JM, Nugent AW. Bench and initial preclinical results of a novel 8 mm diameter double opposed helical biodegradable stent. Catheter Cardiovasc Interv 2016 Nov 15;88(6):902-911.
15. Lara DA, Fixler DE, Ethen MK, Canfield MA, Nembhard WN, Morris SA. Prenatal diagnosis, hospital characteristics, and mortality in transposition of the great arteries. Birth Defects Res A Clin Mol Teratol 2016;106:739-48.
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Pediatric Cardiology 2016 Annual Report
16. Mitchell FM, Prasad SK, Greil GF, et al. Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population. World J Clin Pediatr 2016;5:1-15.
17. Nassar MS, Anderson D, Hussain T. Second stage of hybrid pathway: Have we reached a conclusion? The Journal of thoracic and cardiovascular surgery. 2016;152:1205-6.
18. Nezafat M, Henningsson M, Ripley DP, Dedieu N, Greil G, et al. Coronary MR angiography at 3T: fat suppression versus water-fat separation. MAGMA 2016;29:733-8.
19. Pushparajah K, Wong JK, Bellsham-Revell HR, Hussain T, Valverde I, Bell A, Tzifa A, Greil G, et al. Magnetic resonance imaging catheter stress haemodynamics post-Fontan in hypoplastic left heart syndrome. Eur Heart J Cardiovasc Imaging 2016;17:644-51.
20. Rosenthal DN, Almond CS, Jaquiss RD, Peyton CE, Auerbach SR, Morales DR, Epstein DJ, Cantor RS, Kormos RL, Naftel DC, Butts RJ, et al. Adverse events in children implanted with ventricular assist devices in the United States: Data from the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS). J Heart Lung Transplant 2016;35:569-77.
21. Sleeper LA, Towbin JA, Colan SD, Hsu D, Orav EJ, Lemler MS, et al. Health-Related Quality of Life and Functional Status Are Associated with Cardiac Status and Clinical Outcome in Children with Cardiomyopathy. J Pediatr 2016;170:173-80 e4.
22. Tandon A. Tools to Stay Organized: Using Software to Enhance Efficiency. Congenital Cardiology Today 2016;14:12.
23. Tandon A, Byrne N, Nieves Velasco Forte ML, Zhang S, Dyer AK, Dillenbeck JM, Greil GF, Hussain T. Use of a semi-automated cardiac segmentation tool improves reproducibility and speed of segmentation of contaminated right heart magnetic resonance angiography. Int J Cardiovasc Imaging 2016;32:1273-9.
24. Tandon A, Hashemi S, Parks WJ, Kelleman MS, Sallee D, Slesnick TC. Improved high-resolution pediatric vascular cardiovascular magnetic resonance with gadofosveset-enhanced 3D respiratory navigated, inversion recovery prepared gradient echo readout imaging compared to 3D balanced steady-state free precession readout imaging. Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance 2016;18:74.
25. Tandon A, James L, Henningsson M, Botnar RM, Potersnak A, Greil GF, Hussain T. A clinical combined gadobutrol bolus and slow infusion protocol enabling angiography, inversion recovery whole heart, and late gadolinium enhancement imaging in a single study. Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance 2016;18:66.
26. Thankavel PP, Martho LC, Zeltser I. Response to commentary: Anomalous origin of the left pulmonary artery from the internal carotid artery. Cardiol Young 2016;26:145-6.
27. Thankavel PP, Martho LC, Zeltser I. Anomalous left pulmonary artery origin from internal carotid artery: prospective echocardiographic diagnosis of a previously unknown variant. Cardiol Young 2016;26:139-42.
28. Thankavel PP, Ramaciotti C. Isolated Mitral Cleft in Trisomy 21: An Initially 'Silent' Lesion. Pediatr Cardiol 2016;37:405-8.
29. Thankavel PP, Ramaciotti C. Early echocardiographic predictor of heart failure in cerebral arteriovenous malformations. Cardiol Young 2016;26:1008-12.
30. Thatte NM, Guleserian KJ, Veeram Reddy SR. New-onset cardiac rhabdomyoma beyond infancy in a patient with tuberous sclerosis complex. Cardiol Young 2016;26:396-9.
31. Tran A, Fixler D, Huang R, Meza T, Lacelle C, Das BB. Donor-specific HLA alloantibodies: Impact on cardiac allograft vasculopathy, rejection, and survival after pediatric heart transplantation. J Heart Lung Transplant 2016;35:87-91.
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Pediatric Cardiology 2016 Annual Report
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