Patologia Renal Case 1

A. Lopez-Beltran

João Cassis Rita Marques Pedro Oliveira

Nuno Vau

Case Renal Cancer

• Female 47 y

• Back pain

• CT: Large Renal Tumor (RK)

• Treatment: Radical surgery

• Treatment with everolimus and disease progression

– Multiple Lung metastases

– Multiple retroperitoneal metastases

Pathology: Gross

Pathology: Micro

CD10

CK20

34BE12

CK7

AE1/AE3

Diagnóstico

• Carcinoma Renal de los Conductos Colectores

Variante Medular-like

Integración en Patología Oncologica

Patologo

Oncologo

Patología Molecular

HER-2

FISH Oncocarta

Treatment options

Patología Molecular

• FISH HER-2: Amplificado • Oncocarta (Sequenon): • Somatic mutation profile obtained with iPlex

Single Base Extension and MassARRAY Detection (Sequenom)

• OncoCarta and CLIA panels Sample has been analyzed with two assay panels, OncoCarta and CLIA (see below list of assays included).

• Sample M13-00008: Positive for KRAS G12D mutation. Negative for mutations in remaining assays contained in the panels.

Patologia Molecular

FISH HER-2 Amplificado Trastuzumab

Oncocarta

Positive for KRAS G12D mutation

Negative for mutations in remaining assays

contained in the panels

Follow up

• Patient treated with Trastuzumab

• No progression of disease after 3 month