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Acurian delivers patients and over 8800% ROI Phase: III Site footprint: 81 sites Total enrollment: 700 patients Recruitment situation: 3 protocols (2 rescue, 1 prospective) Services provided: Direct-to-patient outreach; media campaign management; call center/online pre-screening; site services support; tracking and reporting platform; project management Contract terms: Outreach pricing Contract ROI: 8819%* *Calculation: Six months of market opportunity (at modest 2% market share) divided by total fees paid to Acurian. S U C C E S S S T O R Y A C U R I A N Patient Recruitment Solutions STUDY Opioid-induced constipation study stays on track with patient recruitment support 800 700 600 500 400 300 200 100 0 RANDOMIZATIONS NOV 07 OCT 07 DEC 07 JAN 08 FEB 08 MAR 08 APR 08 MAY 08 JUN 08 JUL 08 AUG 08 SEP 08 OCT 08 NOV 08 OIBD STUDY DEC 08 JAN 09 FEB 09 MAR 09 WITH ACURIAN WITHOUT ACURIAN GOAL Protocol 1 2 month time savings Protocol 2 3 month time savings Protocol 3 6 month time savings OPIOID-INDUCED BOWEL DYSFUNCTION Acurian supported a leading pharmaceutical company with patient recruitment for a large, multi-protocol OIBD program that the sponsor was anxious to complete in order to determine which formulation warranted further clinical testing. The collective studies required a sophisti- cated, multi-tactic recruitment approach that expeditiously enrolled these highly coveted patients in a cost-effective manner and tracked all recruitment outcomes through to randomization. Using our patient database and Recruitment Manager platform, Acurian performed direct-to-patient outreach and managed the centralized media campaign of a strategic partner, enabling us to redistribute budget in real-time to the best performing tactics per market. Our collective contribution of nearly 300 randomized patients, or over 40% of enrollment, enabled the sponsor to close enrollment for two of its protocols on time — avoiding two month and three month delays respectively — and close its third protocol four months early — saving six months of enrollment time. www.acurian.com 866.566.5966

Patient Recruitment Solutions Opioid-induced constipation ...Patient Recruitment Solutions S T U D Y Opioid-induced constipation study stays on track with patient recruitment support

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Page 1: Patient Recruitment Solutions Opioid-induced constipation ...Patient Recruitment Solutions S T U D Y Opioid-induced constipation study stays on track with patient recruitment support

Acurian delivers patients and over 8800% ROI Phase: III Site footprint: 81 sites Total enrollment: 700 patients Recruitment situation: 3 protocols (2 rescue, 1 prospective) Services provided: Direct-to-patient outreach; media campaign management; call center/online pre-screening; site services support; tracking and reporting platform; project management Contract terms: Outreach pricing Contract ROI: 8819%*

*Calculation: Six months of market opportunity (at modest 2% market share) divided by total fees paid to Acurian.

SU

C C E S S S

TO

RY

ACURIAN

Pat ien t Recru i tment So lu t ions

S T U D Y

Opioid-induced constipation study stays on track with patient recruitment support

800

700

600

500

400

300

200

100

0

RA

ND

OM

IZA

TIO

NS

NOV 07OCT 07

DEC 07JAN 08

FEB 08MAR 08

APR 08MAY 08

JUN 08JUL 08

AUG 08SEP 08

OCT 08NOV 08

OIBD STUDY

DEC 08JAN 09

FEB 09MAR 09

WITH ACURIAN WITHOUT ACURIAN GOAL

Protocol 12 month time savings

Protocol 23 month time savings

Protocol 36 month time savings

OPIOID-INDUCED BOWEL DYSFUNCTION

Acurian supported a leading pharmaceutical company with patient recruitment for a large, multi-protocol OIBD program that the sponsor was anxious to complete in order to determine which formulation warranted further clinical testing. The collective studies required a sophisti-cated, multi-tactic recruitment approach that expeditiously enrolled these highly coveted patients in a cost-effective manner and tracked all recruitment outcomes through to randomization.Using our patient database and Recruitment Manager platform, Acurian performed direct-to-patient outreach and managed the centralized media campaign of a strategic partner, enabling us to redistribute budget in real-time to the best performing tactics per market. Our collective contribution of nearly 300 randomized patients, or over 40% of enrollment, enabled the sponsor to close enrollment for two of its protocols on time — avoiding two month and three month delays respectively — and close its third protocol four months early —saving six months of enrollment time.

www.acurian.com866.566.5966