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Neuroanatomy & Neurophysiology Brian J. Piper, Ph.D., M.S.

Pathophysiology: Neuroanatomy Part I

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This presentation was given to first year pharmacy students as part of a course on medical physiology and pathophysiology.

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  • 1. Neuroanatomy & Neurophysiology Brian J. Piper, Ph.D., M.S.
  • 2. Goals Major Brain Areas Sensory Motor Emotion Cognition Neuroimaging
  • 3. Spinal Cord Divided into regions: Cervical Thoracic Lumbar Sacral Function Motor Sensation
  • 4. Beneath Skull Dura: thick/tough layer Arachnoid: contains blood vessels Pia: thin layer
  • 5. ______ lobe
  • 6. Match Color
  • 7. Description of 3-Dimensional Space Coronal: section from ear to ear, like a loaf of bread Axial: section that parallels horizon Sagittal: section from front to back mid-sagittal shows brain with left and right cortex separated
  • 8. Corpus Callosum Fibers that connect left and right cortex
  • 9. Anatomical Terminology
  • 10. Cingulate Gyrus Tissue surrounding corpus collosum Anterior Posterior
  • 11. BrainstemThe Medulla is the base of the brainstem thatcontrols heartbeat and breathing. Example: SIDS
  • 12. Cerebellum Located below the occipital cortexCC Important for motor functionBS Site of action of alcohol
  • 13. Cerebellum (a mid-sagittal) Located below theCC occipital cortex Important for motor function BS Site of action of alcohol
  • 14. Functions of Different Cortical Areas Frontal: cognition, executive function Temporal: hearing, olfaction Occipital: vision Parietal: integration of sensory information Dorsal Posterior Anterior Ventral
  • 15. Sensory Areas
  • 16. Thalamus Located in the center of the brain Major relay center, information from spinal cord goes to thalamus, thalamus has many connections to the cortex
  • 17. Hippocampus Bilateral structure Greek for seahorse Essential for memory, especially spatial memory Forms new neuronshttp://www.bris.ac.uk/Depts/Synaptic/info/pathway/hippocampal.htm
  • 18. Animal Research = ?Very helpful, but .
  • 19. Hippocampus Comparison
  • 20. Amygdala The Amygdala consists oftwo lima bean-sized neural clusters linked to the emotions of fear
  • 21. Brain Areas Important for Hormone Control Rene Descartes Pineal Gland Very small subcortical structure Releases the hormone melatonin Hypothalamus Hypo = below therefore located under thalamus Regulates activity of Pituitary Pituitary communicates with other endocrine glands (e.g. testes) 4F!
  • 22. Ventricles: Contain CSF
  • 23. What is the impact of ?
  • 24. http://www.omsi.edu/visit/life/aging/brainText.cfm
  • 25. Brain Imaging Can provide information about anatomy or physiology Imaging procedures differ in their: Spatial resolution: the ability to differentiate nearby brain regions Temporal resolution: the ability to differentiate brain activity at different times
  • 26. Electroencephalography (EEG) 1873-1941 Developed by Hans Berger in 1929 Electrodes are placed on the surface of the skull Electrical activity from the cortex is recorded Time
  • 27. Computed Tomagraphy (EMI scan, axial) Gr: tomos (slice) & graphein (to write). Developed in the 1970s X-ray beams are passed through the head A 2 or even 3- dimensional structural map is created
  • 28. Atypical CT 68 year old man Cerebellar hemorrhage extending into midbrain & ventriclesKlein JP, Ryther RC (2009). Images in clinical medicine. Central nervous system hemorrhage. NewEngland Journal of Medicine, 361(18), 1786.http://www.npr.org/blogs/health/2009/10/ghost_in_the_brain_an_appariti.html?sc=fb&cc=fp
  • 29. Positron Emission Tomography (PET) Radioactive material is injected into the blood Scanner records the radioactivity (positron) in different parts of the brain Provides information about function Very useful for researchFor more detailed information about PET, goto:http://en.wikipedia.org/wiki/Positron_emission_tomography
  • 30. Figure 2. Brain Glucose Metabolic Images Showing Axial Planes at the Level of the Orbitofrontal Cortex Volkow, N. D. et al. JAMA 2011;305:808-813Copyright restrictions may apply.
  • 31. Functional Magnetic Resonance Imaging (fMRI) A cylindrical magnet creates a magnetic field A sensor records blood flow and brain activation Can also be used for just structure White matter Gray matter Ventricle
  • 32. Comparison of Imaging Techniques MeasuresProcedure Brain: Advantage Disadvantage Function Excellent temporal Measures only from brainEEG resolution (msec) surfaceCT Structure Found in many Some radiation exposure hospitals Function Wide variety of Poor temporal resolution (min),PET Poor spatial resolution (cm) uses Radiation exposurefMRI Function Good temporal Patient cannot have resolution (sec), metal implants Good spatial resolution (0.5cm)
  • 33. What plane? Sarah Tappon, 8/5/2009
  • 34. Useful video 2 Mininute Neuroanatomy Overview (Humorous, really!) http://www.youtube.com/watch?v=XAurv6m AWKM
  • 35. CA B D E L K H F G J I
  • 36. and sheep brain
  • 37. Cranial Nerves I. Olfactory: smell (S) II. Optic: vision (S) III. Oculomotor: pupil construction (M) IV. Trochlear: eye movement (M) V. Trigeminal: face & teeth (S), jaw (M) X. Vagus: heart (SM), autonomic nervous system
  • 38. The Nervous System
  • 39. Autonomic Nervous System (ANS) Sympathetic NS Arouses (fight-or-flight)Parasympathetic NS Calms (rest and digest)