7/25/2019 Pathophysiology Acute Pyelonephritis
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Pathophysiology Acute Pyelonephritis
Precipitating Factors
Obstruction of urinary outow, Vesicoureteral Reux,
Neurogenic Bladder, Renal Diseases, Metabolic Disturbances
Predisposing FactorsGender, Older Age, Lifestyle,
n!iron"ent,
#regnancy, $nstru"entation, %&ronic Analgesic Abuse
'yste"atic %irculation
May lead to Renal (ailureLeu)ocyte %asts
*Accu"ulation of +B%
Necrosis of Renal -issueDestruction of'eg"ents of tubules
Bleeding in t&e "ucous
"e"brane of t&e ad.acent
collecting syste"
$ncrease /oly"or/&nuclea
leu)ocytes in t&e tubules and
in t&e interstitiu" surrounding
t&e tubules
%&ange of abscess to lesions'u//uration
*#us (or"ation
'"all abscess in
t&e calyx surfaces
$ncrease +B% and #latelet
$nfection $na""ation of t&e renal
tissue
0idneys
1reters and Bladder
1ret&ra
'yste"atic Arteries
$ntestinal
M2O2
Bacteria gain access to blood xegenous
M2O2
Genitor31rinary
Dysuria
Pain and Pyuria
Pain and bladder retention
Fever(e!er, #ain
