Painful, nUll1b feet. A new option for a frustrating problen1.

Peripheral neuropathy robs your patients of a normal !"fe, They complain of sleepless nights, burning pain and trouble simply

walking. Peripheral neuropathy is probably one of the most common

- and most frustrating - conditions you treat.

Thousands of patients with neuropathy are now

etting relief fro pain eact- 0 th While the symptoms of peripheral neuropathy and its complications

have been difficult or impossible to resolve, you can now offer your

patients a comprehensive, clinically proven program that may reduce

the pain associated with neuropathy and help them recapture the life

they once enjoyed . More than 5,000 therapists, nurses and doctors

are now using and recommending this therapy program. There are

over a thousand Anodyne" Neuropathy Care Centers'" nationwide.

They are located in hospitals and universities, outpatient physical

therapy centers , wound care centers, long term care facilities,

physician offices and home health agencies, so patients may be

referred based on the care setting that is most appropriate for them.

W at is nodyne era y Anodyne emits monochromatic infrared photo energy (MIRETM)

to substantially increase local circulation and temporarily reduce

pain . Anodyne has been designed io maximize the effectiveness

of infrared photo energy using highly efficient Ilight emitting diodes

(LEOs) placed in direct skin contact. The medical images below

show just how substantial these increases in circulation can be.

Will this program provide pain relief for my ti nts?

Pain is often the first symptom to improve in our program , while

functional improvements may take more therapy. Several pain

studies involving over 1,000 patients have been done using Anodyne

Therapy.

The first study examined 784 patients with chronic pain

unresponsive to ultrasound, electrical stimulation, hot packs and

pharmacologic interventions. Nearly 89% of the patients had

excellent to total pain relief within twelve 45-minute Anodyne

Therapy sessions.

Pain Reduction - Chronic Pain (784 patients)

100% ------------------------------------------­80% __8_8_,_8_0/0_____________________________________

60% --____-'--___________________________________

40% ------,---------___________________________

20% ------~------_n~~-----------------------

0% ~~~--------~....------~= 3%~---------1=.==Excellent to Fair to No Relief Total Relief Poor Relief

Brighter area indica e more circulation

40% increase placebo heat therapy

Baseline

400 % increase Anodyne Therapy

After 30 minutes with Anodyne Therapy,

microcirculation increased 400% vs . only

40% with thermal energy alone as shown

by the Moor Scanning Laser Doppler.

Vasodilation , t'e

After 20 minutes with Anodyne Therapy,

microcirculation increased 3200% as shown

by the Moor Scanning Laser Doppler.

Baseline

Anodyne Therapy

The second study surveyed 252 patients with diabetes who had

experienced chronic foot and leg pain. After receiving Anodyne

Therapy, 87% reported substantial reductions in their foot and leg pain.

252 Diabetic 87% Patients with Foot and Leg Pain

% Reporting Reduction in Pain

Place the pads on the area to be treated.

Turn the system on and adjust the energy dial to the appropriate setting.

Let the patient relax for 30-45 minutes.

ats Id m? Most patients say that Anodyne Therapy feels warm and soothing.

Others say they feel some tingling and pulsing, which is normal as blood

flow returns. Some patients respond very quickly in our comprehensive

program, while others take longer based on their degree of impairment .

Our therapy centers will work with your patients as long as they are

willing to work on their functional limitations and are showing progress

toward their goals.

Is it really possible for my patients to reduce their

f II a of f II Several studies have documented that this comprehensive program

can improve balance, Tinetti Gait and Balance Scores, fear of falling

and actual fall rates. Since falls are one of the leading causes of injury

in the elderly, this can help patients get back to functional levels never

thought possible. Data presented at the 2003 American Physical

Therapy Association Combined Sections Meeting demonstrated a

96% reduction in falls in patients with loss of protective sensation

after receiving our recommended comprehensive neuropathy therapy

protocol. (See Gait and Balance Outcomes chart.)

In a survey of 252 diabetic patients who had received a comprehensive

therapy protocol that included Anodyne Therapy, 78% reported

reduction in the number of falls and 80% reported a reduced fear of

falling. More importantly, 72% reported they were able to increase their

activities, which improved their quality of life.

25 1202.7 21.6 98100---­20

11.2

I

I 80 - --- ----­15

60 0.9 10

40 -~-------

5 25 --~~------

4 0--- ----==­0

Before Before After Before After

P <.0001 vs. Before

Reduction in falls Increased activity level

80% 78% 72%

% Reporting % Report ing % Reporting Reduction in Reduction in Increase in

Fear of Falling Actual Falling Daily Activities

N=252

"r ge Number Sites 5.07 Monofilament of 3 Tested

Gait and Balance Outcomes

Average Gait and Balance Total Falls In 90 Days Score (Normal = 28)

A"e there ti

No side effects or drug interactions have beer.

reported as long as Anodyne Therapy is properly

used and monitored. Anodyne Therapy should

not be used directly over or near the womb of a

pregnant woman or over an active malignancy. If

your patients have diabetes, they should check

their blood sugars often during any change in

therapy or activity.

°11 0 9 p tmeot be Unfortunately, diabetes and most other causes

of neuropathic pain are often chronic conditions.

Our therapists recommend home exercises to

help patients continue to improve functionally.

Your patients may also continue Anodyne Therapy

at home to maintain and continue to improve

circulation in their extremities and to provide

temporary pain relief. Contact us for prescription

forms as Medicare or private insurance may cover

the Anodyne Therapy Home System for your

patients when medically necessary. We also offer

an affordable rent-to-own program for patients.

The Anodyne

Therapy Home

System extends

your care.

for your patients, try prescribing treatment in an

Anodyne Neuropathy Care Center. These are now

open in most major cities and new ones are being

added every day. Add a little light to your patients'

lives and you will be amazed at how much better

they feel.

What is our comprehensive approach to caring for those with eroatr'"

Our therapy centers first assess the functional limitations your patients are experiencing, and

how they affect their lives. A comprehensive therapy program is then designed to help them

reach their personal goals.

o t n Therapy may include any or all of the following interventions, depending on the patients'

particular needs:

• Anodyne Therapy to reduce pain and increase circulation to impaired tissues and nerves

• Stretching and strengthening exercises

• Dynamic and static balance exercises

• Massage and the use of other therapeutic modalities for pain

• Sensory integrative techniques to put it all together