P ROGRAM - TERMISPoster Session I Monday, November 11 …. 25 - 32 Poster Session II Tuesday, November 12 …. 33 - 41 Student & Young Investigator Section Welcome & Activities …

The TERMIS-Americas 2013Annual Conference & Exposition

Hos

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by:

CELEBRATING 25 YEARS

OF TRANSFORMATIVE

SCIENCE & ENGINEERING

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2013

November 10-13, 2013

Hyatt Regency Atlanta

Atlanta, Georgia

P R O G R A M

TABLEof CONTENTS

OPENING RECEPTIONHosted by the

Exhibitors and SponsorsSunday, November 10, 2013

7:00 - 9:00 PMLocated in the Regency Ballroom

Welcome …. 4

General Information …. 5

Bench to Business Workshop …. 6

Women in TERM Luncheon …. 7

Opening Symposium …. 8

Opening Day ScheduleSunday, November 10 …. 9

Podium Presentations

Monday, November 11 …. 10 - 14

Podium PresentationsTuesday, November 12 …. 15 - 18

Podium Presentations

Wednesday, November 13 …. 19 - 24

Poster Session IMonday, November 11 …. 25 - 32

Poster Session II

Tuesday, November 12 …. 33 - 41

Student & Young Investigator SectionWelcome & Activities …. 43 - 44

Student Poster Competition …. 45

WFIRM YIA Award Winners …. 46

TERMIS-AM 2013 Award Winners …. 47 - 48

Exhibitor Floorplan and Listing …. 49 - 52

Sponsors …. 53 - 54

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Wel

com

e November 10, 2013

Dear Fellow TERMIS Attendees:

On behalf of the scientific advisory committee, the international community of TERMIS members, and everyone involved in supporting the TERMIS-Americas (TERMIS-AM) 2013 Conference, we would like to personally welcome you to Atlanta, Georgia. The theme of this year’s meeting, “Celebrating 25 years of Transformative Science & Engineering,” was inspired by the first federally funded tissue engineering workshop in 1998. The opening plenary symposium on Sunday will provide talks from several leaders on how key areas of the field have evolved over the past 25 years, as well as share insights on future directions of the field.

Planning for the 2013 TERMIS-AM Conference has been a great success, reflected by an anticipated record-breaking attendance of over 1,000. We received over 600 abstracts, resulting in approximately 200 oral presentations and 400 poster presentations - a clear testament to the continued growth of this community. As a result, we have added several new and exciting elements to the program, including the first ever TERMIS-AM conference dinner, a Women in Tissue Engineering & Regenerative Medicine luncheon, and a session focused on public policy. These new activities as well as enhancement of existing outreach and training opportunities will be supported in part by grants from the National Institutes of Health and National Science Foundation. We are very excited about this year’s scientific program comprised of session topics that focus on the fundamental principles, emerging strategies, and practical applications of the latest advances in tissue engineering and regenerative medicine. In addition to emphasizing basic and applied scientific research themes that broadly impact different tissue and organ systems, we have also included a series of sessions dedicated to clinical translational work.

We will hear from distinguished keynote lecturers speaking about innovative approaches that impact new tissue engineering and regenerative medicine strategies, including Deepak Srivastava, MD, Younger Director of the Gladstone Institute of Cardiovascular Disease and Director of the Roddenberry Stem Cell Center at Gladstone; Valerie M. Weaver, PhD, Associate Professor, Departments of Surgery and Bioengineering and Therapeutics, and Director, Center for Bioengineering and Tissue Regeneration, University of California, San Francisco; and James M. Wells, PhD, Endowed Chair in Regenerative Medicine and Perinatal Endocrinology and Director, Pluripotent Stem Cell Facility, Cincinnati Children’s Hospital Medical Center.

Realizing the importance of a strong trainee network, the Student and Young Investigator Section of the Americas chapter (SYIS-AM) has organized a number of exciting activities at the meeting. With support from the National Science Foundation, we were able to expand many of the SYIS events this year, including doubling the numbers of participants of the Mentoring Lunch and Career Panel. In addition, they have organized the first-ever local area high school outreach event.

Finally, conference guests are invited to an evening of fun and celebration at the conference gala dinner and reception to be held Tuesday evening at the World of Coca-Cola, hosted by Georgia Institure of Technology Parker H. Petit Institute for Bioengineering and Bioscience.

We are very proud to host the TERMIS-AM 2013 meeting and welcome you to our city. Although it has been over a year in the making, the success of this year’s meeting reflects the efforts of past chairs, advisory committees, trainees and attendees, to build a healthy and vibrant society and for that reason, we encourage you to celebrate this week with us and enjoy the 25th anniversary of our field’s birth!

Sincerely,

Robert E. Guldberg, PhD TERMIS-AM 2013 Conference Chair Executive Director of the Parker H. Petit Institute for Bioengineering and Bioscience,Professor, George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology

Todd C. McDevitt, PhD TERMIS-AM 2013 Scientific Program Chair Petit Faculty Fellow, Parker H. Petit Institute for Bioengineering and Bioscience Director, Stem Cell Engineering Center, Georgia Institute of TechnologyAssociate Professor, Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University

GENERAL INFORMATION

SCIENTIFIC ADVISORY COMMITTEERobert Guldberg, PhD, Georgia Institute of Technology, Conference Chair and TERMIS-AM Chapter Chair

Todd McDevitt, PhD, Georgia Institute of Technology, Scientific Program Chair

Stephen Badylak, PhD, MD, University of Pittsburgh Dolores Baksh, PhD, Organogenesis Mário Barbosa, PhD, INEB Jason Burdick, PhD, University of Pennsylvania Robert Christy, PhD, United States Army Institute of Surgical Research Jennifer Elisseeff, PhD, Johns Hopkins University John Fisher, PhD, University of Maryland Andrés García, PhD, Georgia Institute of Technology Sharon Gerecht, PhD, Johns Hopkins University Sarah Heilshorn, PhD, Stanford University Dietmar Hutmacher, PhD, Queensland University of Technology Gilson Khang, PhD, Chonbuk National University Masahiro Kino-Oka, PhD, Osaka University Alison McGuigan, PhD, University of Toronto Antonios Mikos, PhD, Rice University William Murphy, PhD, University of Wisconsin Sean Palecek, PhD, University of Wisconsin Abhay Pandit, PhD, National University of Ireland Shelly Sakiyama-Elbert, PhD, Washington University Katja Schenke-Layland, PhD, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB Michael Sefton, ScD, University of Toronto Johnna Temenoff, PhD, Georgia Institute of Technology Ned Waller, PhD, MD, Emory University Jennifer West, PhD, Duke University

ONSITE REGISTRATION AND CONFERENCE CHECK-INPhoto ID is required at check-in. The registration desk will be open at the following times:

• Sunday, November 10 from 7:00 AM – 7:00 PM• Monday, November 11 from 7:00 AM – 5:00 PM• Tuesday, November 12 from 7:00 AM – 5:00 PM• Wednesday, November 13 from 7:00 AM – 5:00 PM

OPENING RECEPTION• Sunday, November 10, 2013• 7:00 PM - 9:00 PM• Exhibit Hall – Regency Ballroom

54

PRECONFERENCE WORKSHOP • SUNDAY, NOVEMBER 10, 2013 • 8:00AM – 2:00PM

Bench to Business Workshop Organized by the TERMIS-AM Industry Committee

This workshop will feature experienced speakers working directly on the challenges associated with technology transfer for the commercialization of academic research. Topics will include designing product development studies to facilitate industrial interest, translation and commercialization, developing and protecting commercially-relevant intellectual property, working with university technology transfer offices, partnering with existing companies including biotechnology and establish corporate entities, developing a business plan and attracting funding to support commercialization of the academic technology. Attendees will benefit from real-world case studies, practical examples and guidance from experienced thought leaders. The goal of the workshop is for attendees to leave with actionable concepts of how to evaluate their current research enterprise for technology and start the process toward potential commercialization. The knowledge and tools gained from the workshop is anticipated to represent successful approaches used to accelerate the commercialization of your research efforts.

Registration fee: $99.00

Agenda:

8:00 AM to 8:15 AM Opening Remarks Tim Bertram

8:15 AM to 9:15 AM Directing Academic Research toward Commercializable Technologies H. Lee Herron

9:15 AM to 10:15 AM Strategies for IP Protection and Business Development Christopher Jeffers

10:15 AM to 10:30 AM Break

10:30 AM to 11:30 AM Funding a Startup, Developing the Business, Exit Strategies Cory Anderson

11:30 AM to 12:45 PM Lunch

12:45 PM to 1:45 PM Working with Large Companies as Partners or Exit Strategies Cheryl Blanchard

1:45 PM to 2:00 PM Closing Remarks Tim Bertram

WOMEN IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE LUNCHEON

“Avoiding Traps” Sunday, November 10th from 11:30 AM - 2:00 PM

Registration for the event is FREE. The maximum number of attendees for the Women in TERM Luncheon is 100, so registrations will be awarded on a first-come first-serve basis.

Invited Discussants: Gordana Vunjak-Novakovic, Columbia University Molly Shoichet, University of Toronto Bob Nerem, Georgia Institute of Technology Michael Sefto, University of Toronto Milica Radisic, University of Toronto Shelley Sakayama-Elbert, Washington University Alison McGuigan, University of Toronto Katja Schenke-Layland, University Women’s Hospital Tübingen

Research efforts in tissue engineering have intensified in the past 25 years, coinciding with the increased efforts to promote enrollment of female students in all areas of engineering. As tissue and biomedical engineers, we have been successful in recruiting female students into our undergraduate and graduate programs. More than 50% of PhD degrees are awarded each year to female students in areas of Engineering and Life sciences. Majority (~60%) of NSF and NIH pre-doctoral awards are awarded to female students, however only 20-30% of junior faculty awards are awarded to female faculty (NSF and NIH Accountability Report 2008). Therefore, some of our best students are lost as they progress through the academic ranks for issues other than performance or ability. Enabling them to realize full potential of their careers will be beneficial for the development of the emerging fields of tissue engineering and regenerative medicine.

At the 2013 TERMIS-AM we will organize the first ever Women in TERM Luncheon with the purpose of fostering support and professional development of young women in our field. We are the first TERMIS continental chapter to organize such an event. We hope we will be able to transfer our best practices to our sister continental chapters in Europe and Asia-Pacific. We have gathered a group of leading tissue engineering and regenerative medicine researchers who are willing to support this event. Our diverse group includes women at different stages of career development: established, mid-career and pre-tenure, as well as senior researchers who have supported career developments of young scientists in the past three decades (Sefton, Nerem). Each speaker was asked to spend 5-10 minutes presenting what they perceive major issues/solutions are to avoiding traps in female career development with the remaining time spent actively engaged in discussions/questions from the audience.

76

TERMIS-AM OPENING SYMPOSIUM - SUNDAY, NOVEMBER 10, 2013

Tissue Engineering and Regenerative Medicine: Origins and Its EvolutionChair: Bob Nerem, Georgia Institute of Technology

Registration for the Opening Symposium is included in your conference registration.

The opening symposium “Tissue Engineering & Regenerative Medicine: Origins and its Evolution” will gather past, present and future leaders to mark this important 25-year milestone since the first federally-funded tissue engineering meeting held at Granlibakken, Lake Tahoe, California in February 1988.

As the field of tissue engineering and regenerative medicine has evolved over the years, resulting in groundbreaking medical science discoveries, it is important to revisit the discipline’s history and lessons learned in order to guide the future of this ever-expanding, multidisciplinary field. Special recognition will also be given to the major pioneering leaders of the field and their important contributions. The symposium will be of great value to trainees and young investigators who will gain a better understanding and appreciation for tissue engineering and regenerative medicine as a research discipline.

2:00 PM Introduction to the History of Tissue Engineering & Regenerative Medicine Bob Nerem

2:20 PM Biomaterials and Regenerative Medicine Michael Sefton

2:45 PM The Role of Biomechanics in the Evolution of Regenerative Medicine David Butler

3:10 PM Impact of Stem Cells on the Evolution of Tissue Engineering & Regenerative Medicine Jane Lebkowski

4:00 PM Break

4:25 PM Emergence of Industry Geoff McKay

4:50 PM Clinical Need and Healthcare Impact of Tissue Engineering Christopher Breuer

5:15 PM Federal Government Support of Tissue Engineering and Regenerative Medicine: Past, Present, and Future Christine Kelley

5:40 PM Panel Discussion on Future Directions

Kristi Anseth Anthony Atala Robert Deans Andrés Garciá David Mooney

6:30 PM Adjourn & Welcome Reception

DAY 1 - SUNDAY, NOVEMBER 10, 2013

8:00 AM - 2:00 PM

TERMIS-AM Industry Committee: Bench to Business Workshop

Hanover CD

11:30 AM - 2:00 PM Women in TERM Luncheon Hanover FG

12:00 PM - 2:00 PM SYIS-AM Lab & Campus Tours

2:00 PM - 6:30 PM Tissue Engineering & Regenerative Medicine: Origins & Evolution Centennial III & IV

7:00 PM - 9:00 PM Opening Reception Regency Ballroom

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DAY 2 - MONDAY, NOVEMBER 11, 2013DAY 2 - MONDAY, NOVEMBER 11, 2013

8:00 AM Welcome Announcement - Centennial III & IV

8:05 AM Keynote Speaker I - James Wells - Centennial III & IV

9:00 AM Lifetime Achievement - Bob Nerem - Georgia Institute of Technology

9:30 AM Coffee Break with Poster Viewing - Regency Ballroom

Session I: Biomaterials Regulation of Morphogen Presentation

Cell Responses to Engineered Matrices

Drug Delivery Principles

Mechano-transduction

10:00-11:30 AM

Session Chairs

Kristyn Masters Andrés Garciá Gilson Khang Adam Engler

Johnna Temenoff Brendan Harley Elizabeth Loboa Brent Hoffman

Student Co-Chair

Minh Khanh Nguyen Adam Taylor Alexander Baume Merlin Rajesh Lal L P

Meeting Room

Centennial I Centennial II Centennial III Centennial IV

10:00 - 10:15 AM

Bill Murphy Kyung Min Park Brian Evans Adam Engler

University of Wisconsin The Johns Hopkins University

Vanderbilt University University of CaliforniaSan Diego

Bioinspired Morphogen Regulation in the Stem Cell Microenvironment

Hypoxia-Inducible Hydrogels for Regenerative Medicine

MK2 Inhibitory Nano-Polyplexes Prevent Intimal Hyperplasia Ex Vivo in Human Vein and In Vivo in a Rabbit Transplant Model

High Throghput Assessment of Focal Adhesion-Based Mechanotransduction Candidates

10:15 - 10:30 AM

Jennifer Bain Alison Douglas Song Seto Vincent Fiore

University of Alabama at Birmingham

Georgia Institute of Technology



BMP2 Mimetic Peptide Anchored to Bone Graft Materials Via a Specific Bone Binding Domain Enhances Osteoinductivity

Incorporation of pNIPAM Microgels into Fibrin Matrices for Enhanced Cell Infiltration and Wound Healing

Tuning the Interactions of Soluble Protein:Heparin Complexes with GAG-based Hydrogels

Thy-1 Regulates Lung Fibroblast Mechanotransduction of Extracellular Matrix Stiffness

10:30 - 10:45 AM

Marian Hettiaratchi Alex Laperle Daniel Lynam Leah Pagnozzi


University of Wisconsin-Madison

Michigan State University Cornell University

Controlled Presentation of Bioactive BMP-2 via Heparin Methacrylamide Microparticles

Human Pluripotent Stem Cells Produce ECM that Promotes Self-Renewal

Controlled Brain Derived Neurotrophic Factor Release from Layer-by-Layer Coated Hydrogel Scaffolds for Nerve Repair

Cyclic Anisotropic Strain Mediates Myofibroblast Differentiation through Activation of SMAD2 Phosphorylation

Meeting Room


10:45 - 11:00 AM

Roshan James Young Wook Chun Andrew Khalil James Henstock

The University of Connecticut Health Center

Vanderbilt University University of Wisconsin-Madison

Keele University

Achilles Tendon Regeneration Using a Bioresorbable Biomimetic Scaffold, Stem Cells and Growth Factor Composite

Maturation of Human iPSC-derived Cardiomyocytes on Combinatorial Polymer Fiber Matrix

Optimized Inorganic Coatings of Microparticles for Non-Viral Transfection of Stem Cell Aggregates

Remote Controlled Mechnotransduction Via Magnetic Nanoparticles Promotes Osteogenesis; Applications for Injectable Cell Therapy

11:00 - 11:15 AM

Rene Olivares-Navarrete Amr Abdeen Jaclyn Obermeyer Tom Bongiorno

Virginia Commonwealth University

University of Illinois at Urbana Champaign

University of Toronto Georgia Institute of Technology

Wnt and BMP Signaling Molecules are Affected by Osteogenic Induction Medium in Osteogenesis In Vitro

Mesenchymal Stem Cell Angiogenic Potential depends on Extracellular Matrix Composition and Stiffness

Minimally Invasive Delivery of Brain-Derived Neurotrophic Factor to the Brain

Mechanical Stiffness as an Indicator of Osteoblastic Human Mesenchymal Stem Cell Differentiation

11:15 - 11:30 AM

Laxminarayanan Krishnan

Neil Davies Shalini Saxena Jeffrey Jacot


University of Cape Town


Rice University

Is Alginate-based BMP-2 Delivery a Viable Alternative to Current Clinical Treatments for Large Bone Defects?

Cell Type Specific Invasion of Hydrogels Polymerised with Different Matrix Metalloproteinase Cleavage Sites

Raspberry-Structured Microgel Heteroaggregates for Encapsulation and Delivery of Morphogens

Liquid Crystal Elastomers for Strain Conditioning of Cardiomyocytes

11:30 AM Lunch Break with Poster Viewing - Regency Ballroom

11:30 AM Student Career Panel - The Learning Center

11:30 AM TERMIS-AM Council Meeting with Lunch - EC Suite 219 2nd Floor of Atrium Tower

Session II: Composite & Spatially Engineered Materials

Engineering Matrices for Tissue Regeneration

Engineering Morphogenic Environments

Engineering Tissues In Vitro for Screening & Diagnostics

1:00 - 2:30 PMSession Chairs

Ipsita Banerjee Sarah Heilshorn Alison McGuigan James Hickman

Krish Roy Rene Olivares-Navarrete

Bill Murphy Milica Radisic

Session:Student

Co-Chair

Anthony Melchiorri Joydeep Kundu Samer Zaky Eliza Fong

1110

Meeting Room


1:00 - 1:15 PM

Brendan Harley Molly Shoichet Jeff Morgan James Hickman

University of Illinois at Urbana-Champaign

University of Toronto Brown University University of Central Florida

Engineering Coincident Gradations of Structural and Biochemical Cues for Tendon-Bone Junction Repair

Engineering The Cellular Microenvironment

Micro-Mold Design Controls the 3D Morphological Evolution of Self-Assembling Multi-Cellular Microtissues

Low Cost Microphysiological System with Analytics

1:15 - 1:30 PM

Michael Hill Guoguang Niu Sebastian Barreto

Case Western Reserve University

Wake Forest University Johns Hopkins University

Biodegradable Hydrogels Presenting a Gradient of siRNA for Spatial Control of Cell Gene Expression

Cell-Seeded Gelatin-Based Scaffold for Regenerating the Corneal Endothelium

Novel In Vitro Model for Microvasculature Reveals Regulation of Circumferential ECM Organization by Curvature

1:30 - 1:45 PM

Lucas Kinard Supansa Yodmuang David Belair Tracy Hookway

Rice University Columbia University University of Wisconsin-Madison


Oligo(poly(ethylene glycol) fumarate) as a Synthetic Hydrogel Carrier for Demineralized Bone Matrix

Silk Fiber-reinforced Hydrogels for Cartilage Tissue Engineering

iPS-Derived Endothelial Cells Exhibit Sprouting in Synthetic Hydrogel Arrays

Engineering 3D Cardiac Microtissues from Human Pluripotent Stem Cells

1:45 - 2:00 PM

Qiongyu Guo Daniel Puperi Glen Kirkham Monica Moya

Johns Hopkins University Rice University University of Nottingham University of California, Irvine

Incorporation of Chondroitin Sulfate Bioadhesive into Bioactive Glasses for Repairing Critical Size Bone Defects in Rabbits

Hyaluronan Hydrogels for Biomimetic Spongiosa Layer of Tissue Engineered Aortic Valve

Holographic Optical Tweezers as a Tool for the Study of Stem Cell Microenvironments

iPS Human Derived Tissues for Patient-Specific Drug Screening

2:00 - 2:15 PM

Chris Bashur Shreya Raghavan M.K. Sewell-Loftin Jia-Ling Ruan

Cleveland Clinic Wake Forest School of Medicine

Vanderbilt University University of Washington

Composition of Intra-Peritoneal Conduits Impacts Phenotype of Recruited Cells and Matrix Generative Outcomes

Neuroglial Differentiation of Enteric Neuronal Progenitor Cells as a Function of Extracellular Matrix Composition in Tissue Engineered Intestinal Constructs

Mechanical Regulation of Endocardial EMT and Cell Migration on Collagen-Hyaluronic Acid Gels

Effect of Mechanical Strain on Engineered Tissue from Stem Cells-Derived Progenitors

Meeting Room


2:15 - 2:30 PM

Johnna Temenoff Michael Jaeggli Taby Ahsan Lindsay Wray

Georgia Institute of Technology and Emory University

Clemson University Tulane University Tufts University

Biomaterials to Enhance Mesenchymal Stem Cell Response to Soluble Cues

Assembly and Testing of Tri-layered Tissue Engineered Heart Valves in Physiologically Relevant Conditions

Role of Fibroblasts and Mesenchymal Stem Cells in Regulating Regeneration Processes

Engineering the Vascular Niche: Development of a Basement Membrane Model for Studying Megakaryopoiesis In Vitro

2:30 PM Break with Poster Viewing - Regency Ballroom

Session III: Biomaterials for Cell Delivery & Recruitment

Reproductive Biology

Engineering Multicellular Morphogenesis

Integration of ‘omics in Regenerative Medicine3:00 -

4:30 PMSession Chairs

Elizabeth Lipke Lonnie Shea Taby Ahsan Melissa Kemp

Cherie Stabler Ariella Shikanov Laura Suggs William Stanford

Student Co-Chair

Aleksander Skardal Zegbeh Jallah Carlos Kengla Shruti Balaji

3:00 - 3:15 PM

Sarah Heilshorn Lonnie Shea Alison McGuigan Marjorie Brand

Stanford University Northwestern University

University of Toronto Ottawa Hospital Research Institute

Injectable Matrices for Delivery of Adipose-derived Stem Cells to Heal Critical-size Bone Defects

Biomaterials for Fertility Preservation: Early Stage Ovarian Follicle In Vitro Culture and Transplantation

Generating Robust Tissue Boundaries to Enable Stable Patterning of an Engineered Tissue In Vitro

Trichostatin A Enhances the Vascular Repair Function of Injected Human Endothelial Progenitors by Increasing TAL1-Dependent Cell Migration

3:15 - 3:30 PM

Amy Cheng Melissa Kinney


Georgia Institute of Technology & Emory University

Integrin-Specific Hydrogels for the Delivery of Human Mesenchymal Stem Cells in Bone Repair

Biophysical Properties of 3D Pluripotent Microenvironments Regulate Microtissue Morphogenesis

DAY 2 - MONDAY, NOVEMBER 11, 2013DAY 2 - MONDAY, NOVEMBER 11, 2013

1312

Meeting Room


3:30 - 3:45 PM

Vince Beachley Joanna Burdette Cheston Hsiao Jochen Ringe

Johns Hopkins University University of Illinois at Chicago


Charité-University Medicine Berlin

Effect of Variable Tissue ECMs on Cell Function/Behavior

Development of an Ex Vivo Female Reproductive Tract in a 3D Microphysiologic Setting

Human Pluripotent Stem Cell Culture Density Affects Hippo Pathway Signaling in 2D and 3D

Changes in N-Glycosylation Profile of Human MSC During Adipogenic Development - Towards a Next Generation of Markers for Regenerative Medicine

3:45 - 4:00 PM

Guang Yang Pamela Kreeger Laura Geuss Eric James

University of Pittsburgh University of Wisconsin-Madison

The University of Texas at Austin

University of Connecticut

Tendon-Derived Extracellular Matrix Enhances Tenogenic Differentiation of Human Adipose-Derived Stem Cells Cultured in 3-Dimensional Collagen Scaffold under Tension

An In Vitro Model to Analyze Cell-Cell Interactions in Endometriosis

Magnetic Attraction of Paramagnetic Beads Influences Lineage Commitment in Embryoid Bodies

MicroRNA 29a Mimic Loaded Gelatin Nanofibers as an Osteogenic Scaffold for Bone Tissue Engineering

4:00 - 4:15 PM

Ashwin Nair Angela Pannier Angela Xie Richard Carpenedo

University of Texas at Arlington

University of Nebraska-Lincoln


Ottawa Hospital Research Institute

Healing Bone Using Autologous Stem Cell Recruiting and Differentiating Scaffolds

The Effect of Soluble Uterine Factors on Porcine Embryo Development Within a Three-Dimensional Alginate Matrix System

Adhesion-dependent Morphogenesis of Human Embryonic Stem Cells in Patterned Chemically Defined Environments

Dynamic Gene Regulatory Networks Controlling Mesendoderm Differentiation of Human Embryonic Stem Cells

4:15 - 4:30 PM

Harsha Ramaraju Sunyoung Joo Yun Wang Melissa Kemp

University of Michigan Wake Forest University Georgia Institute of Technology


Improving Specificity of MSC Attachment to Biomaterials with Dual Functioning Phage Derived Peptides

A Novel Two-Step Strategy to Generate Functional Ovarian Follicles

Skeletal Development in Embryonic Stem Cell 3D Aggregates

Multivariate Analysis in Tissue Engineering and Regenerative Medicine: Applications and Opportunities

4:30 - 6:00 PM

Exhibit Viewing/Reception - Poster Session I Regency Ballroom

7:00 PM SYIS Reception - See page 44 for details

DAY 3 - TUESDAY, NOVEMBER 12, 2013DAY 2 - MONDAY, NOVEMBER 11, 2013

8:00 AM Welcome Announcement - Centennial III & IV

8:05 AM Keynote Speaker II - Deepak Srivastava - Centennial III & IV

9:00 AM Senior Scientist Award - William R. Wagner - University of Pittsburgh

9:15 AM Young Investigator Award - Alison P. McGuigan - University of Toronto

9:30 AM Coffee Break with Poster Viewing - Regency Ballroom

Meeting Room


Session I: 10:00-

11:30 AM

Non-destructive Phenotype Analysis

Cell Reprogramming Engineering of Scaffold Material Properties

Vascularization of Engineered Tissues

Session Chairs

David Kohn Sean Palecek Julie Babensee Sharon Gerecht

Molly Stevens Shelly Sakiyama-Elbert Elizabeth Cosgriff Hernandez

Student Co-Chair

Jialing Ruan Casey Roberts Aline Thomas Bao Nguyen

10:00 - 10:15 AM

David Kohn Paul Krebsbach Paul Bonvallet Shulamit Levenberg

University of Michigan

University of Michigan University of Alabama at Birmingham

Technion

Assessing Spatial Variance in Collagen Maturity: Importance of Tissue History

Derivation of Xenogeneic-free and Transgene-free Human iPSCs on Synthetic Substrates

Microporous Electrospun Dermal-Mimetic Scaffolds Promote Rapid and Effective Skin Regeneration

Olfactory Bulb-Derived Cells Seeded on 3D Scaffolds Exhibit Neurotrophic Factor Expression and Pro-Angiogenic Properties

10:15 - 10:30 AM

Jim De Yoreo John Martin Daphne Hutton

Pacific Northwest National Laboratory

Vanderbilt University Johns Hopkins University

The Energetics of Collagen-Hydroxyapatite Interactions and its Influence on the Architecture of Bone

In Vivo Performance of an ROS-degradable Tissue Engineering Scaffold

Effects of Inflammatory Cytokines on Engineering Vascularized Bone

10:30 - 10:45 AM

Liisa Kuhn Brian Diekman Lauren Priddy Anthony Awojoodu

University of Connecticut Health Center

Duke University Medical Center



Collagen Type I Reporter Mice: a Tool for Determining Progenitor Cell Differentiation to Functional Osteoblasts

Enhancing the Regenerative Capacity of Engineered Cartilage by Silencing the Cell Cycle Inhibitor p21

Improved Quality of Regenerated Bone Using Oxidized Alginate Hydrogels

The Tale of Two Types: Sphingosine 1-Phosphate Receptor Three in the Angiocrine Recruitment of Anti-Inflammatory Monocytes

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DAY 3 - TUESDAY, NOVEMBER 12, 2013DAY 3 - TUESDAY, NOVEMBER 12, 2013

Meeting Room


10:45 - 11:00 AM

David Tran Chenyi Pan Anthony Melchiorri Angela Zachman

University of California, Irvine


University of Maryland Vanderbilt University

FLIM Phasor Analysis Characterizes Metabolic Maturation of Human iPS-derived Cardiomyocytes by Cardiac-Derived Extracellular Matrix

Regulation of H19/Igf2 Locus by Insulator Binding Protein and Linker Histones in Embryonic Stem Cells

Combinatorial Surface Modification of a Poly(Glycolic-co-Lactic Acid) - Poly(DL-Lactide-co-Caprolactone) Small-Diameter Vascular Graft via CD34 Antibody and VEGF to Enhance Endothelialization

Peptide-functionalized Injectable Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease

11:00 - 11:15 AM

Rameshwar Rao Amanda Smith Ana Gonçalves Eunna Chung

University of Michigan

Washington University in Saint Louis

3B´s Research Group The University of Texas at Austin

Nondestructive Evaluation of Mineralization and Osteoblast Phenotype in Engineered Tissues Using Spectral Ultrasound Imaging

Direct Reprogramming of Mouse Fibroblasts to Cardiomyocytes Using Yamanaka Factors on Engineered Poly(ethylene glycol) (PEG) Hydrogels

Flow Perfusion and Magnetic Stimulation of SPCL Scaffolds dopped with Nanosized Magnetic Particles for Tendon Regeneration

Successful Employment of PEGylated Fibrin Hydrogels to Enhance Regenerative Actions of Adipose-derived Stem Cells for Tissue Engineering Applications

11:15 - 11:30 AM

Molly Stevens Shigang Lin Lonnie Shea Abritee Dhal

Imperial College London

University of Western Ontario

Northwestern University Wake Forest School of Medicine

State of the Art Materials Analysis of Engineered Tissue

Activation of Transcription Factor GAX and Concomitant Downregulation of Il-1β and ERK1/2 Modulate Vascular Smooth Muscle Cell (VSMC) Phenotype on 3D Fibrous Scaffolds

Modulation of the Islet Microenvironment to Support Islet Engraftment and Function Using PLG Scaffolds

Development of an Acellular Porcine Liver Approach for Bioengineering of Livers for Transplantation

11:30 AM Lunch Break with Poster Viewing - Regency Ballroom

11:30 AM Student Meet Mentor Lunch - Hanover AB

Session II: 1:00 -

2:30 PM

Computational Modeling

Cell Engineering Tissue Modulation via Biomaterials

Engineering of Vascularization Strategies

Chairs Roger Kamm Josh Leonard Jan Stegemann Eric Brey

Anand Asthagiri Kris Saha Sarah Stabenfeldt Ed Botchwey

Student Co-Chair

Jean-Michel Bourget Hyunhee Ahn Chan Ho Park Amr Abdeen

Meeting Room


1:00 - 1:15 PM

Anand Asthagiri Charles Gersbach Shyam Patel Robert Tranquillo

Northeastern University

Duke University University of California, Berkeley

University of Minnesota

Predicting the Evolutionary Tuning of Developmental Multicellular Patterns

Custom Redesign of the Human Genome with Engineered DNA-Binding Proteins

Enhanced Tissue Ingrowth with Chemical Modification of Poly(Lactide-Co-Caprolactone) Microfibrous Scaffolds

Aligned Engineered Microvessels with High Lumen Density via Cell-Induced Fibrin Gel Compaction and Interstitial

1:15 - 1:30 PM

Douglas White Ashley Brown Monica Moya




Quantitatively Assessing Spatial Patterns of Differentiation in Aggregates of Mouse Embryonic Stem Cells

Induction of Fibrin Gel Contraction by Synthetic Platelets for Enhanced Wound Healing

A Dual-Chamber Microfluidic Device to Study the Role of Interstitial Flow and Cell-Cell Contact on Vessel

1:30 - 1:45 PM

Elif Bayrak Wan-Ju Li James Pinney Joel Boerckel

Illinois Institute of Technology


University of California, San Francisco

Cleveland Clinic

Multi-Agent Model of Tissue Growth and Vascularization in Porous Scaffolds

Osteogenesis of Human Mesenchymal Stem Cells Enhanced by Osteoprotegerin through Activation of Nuclear Factor-kappa B

Therapeutic Microstructures for the Attenuation of Fibrosis after Myocardial Infarction

MKP-1 Positively Regulates Neovascularization and Angiogenic Gene Expression

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DAY 4 - WEDNESDAY, NOVEMBER 13, 2013 DAY 3 - TUESDAY, NOVEMBER 12, 2013

1:45 - 2:00 PM

Esmaiel Jabbari Aubrey Tiernan Shanmugasundaram Natesan

Christopher Nelson

University of South Carolina


United States Army Institute of Surgical Research

Vanderbilt University

Simulation of BMP2-derived Peptide Aggregation Conjugated to Amphiphilic PEG Macromers in Aqueous Solution

Development of a Pancreatic Substitute Based on Genetically Engineered Intestinal Endocrine Cells

Supercritical CO2-Treated Human Amniotic Membrane and Adipose Derived Stem Cells based Epithelial Autograft for Wound Regeneration

Proline Hydroxylase Domain 2 Silencing Enhances Vascularization of Tissue Scaffolds In Vivo

Meeting Room


2:00 - 2:15 PM

Ipsita Banerjee Dong Wang Jeong Hun Park Tatsuya Osaki

University of Pittsburgh

University of California, Davis

POSTECH University of Tsukuba

Systems Analysis of Signal Transduction Pathway governing Self-renewal of Human Embryonic Stem Cells

Sox10+ Adult Stem Cells Contribute to Wound Healing and Tissue Regeneration

Indirect Rapid Prototyping of a Tracheal Bellows Graft and its Application to Tracheal Reconstruction

Rapid Assembly of Perfusable Microvascular-Like Structures by Electrochemical Cell Transfer

2:15 - 2:30 PM

Roger Kamm Kim O’Connor Tarun Saxena Georgia Papavasiliou

Massachusetts Institute of Technology

Tulane University Georgia Institute of Technology & Emory School of Medicine

Illinois Institute of Technology

Modeling Force Sensing through Modulation of Cytoskeletal Tension

Isolation of a Subpopulation of Mesenchymal Stem Cells with Enhanced Survival Based on Expression of Neuron-Glial Antigen 2

Spatiotemporal Assessment of the Blood-Spinal Cord Barrier Permeability to Nanocarriers

Evaluation of Sensitivity and Specificity of MMP Substrates in PEG Hydrogels for Neovascularization

2:30 - 4:00 PM

Exhibit Viewing/Reception - Poster Session II Regency Ballroom

4:00 - 5:00 PM

TERMIS-Americas Thematic Working Interest Groups (TWIGs) Meetings – The Learning Center

7:00 PM Evening Special Event - at World of Coca-Cola – 121 Baker Street NW, Atlanta

8:00 AM Welcome Announcement - Centennial III & IV8:05 AM Keynote Speaker III - Valerie Weaver - Centennial III & IV9:00 AM MAL Outstanding Student Award - Rameshwar R. Rao - University of Michigan9:10 AM WFIRM YI Awards Presentations

Minh Khanh Nguyen, PhD - Eben Alsberg LaboratoryDepartment of Biomedical EngineeringCase Western Reserve UniversityMelissa A. KinneyWallace H. Coulter, Department of Biomedical Engineering - Todd McDevitt LaboratoryGeorgia Institute of Technology and Emory University

9:30 AM Coffee Break - Terrace FoyerMeeting Room

Centennial III Centennial IV Regency V Regency VI Regency VII

Session I: 10:00 -

11:30 AM

Imaging Technologies

Systemic Regenerative Effects

Acellular Matrix Technologies

Tumor Biology: Lessons Learned

Translational Approaches of Stem Cells and Regenerative Medicine TechnologiesTranslational Approaches Translational with Pluripotent Stem Cells

Session Chairs

Craig Duvall Bruce Bunnell Steve Badylak Ravi Bellamkonda

Rahul Thakar

Katja Schenke-Layland

Manu Platt Brenda Ogle Dietmar Hutmacher

Kevin Whittlesey

Student Co-Chair

Shreya Raghavan Jenny Robinson Henk Hoogenkamp Amit Aurora

10:00 - 10:15 AM

Kristin Poole Cherie Stabler Michael Zimber Lonnie Shea Rahul Thakar Kevin Whittlesey

Vanderbilt University

University of Miami

Histogen, Inc. Northwestern University

California Institute for Regenerative Medicine

Intravital Optical Imaging to Evaluate Peripheral Arterial Disease Therapies

Long-term Survival of Islets Encapsulated in Ultrathin Coatings within a Fully Mismatched Allograft Murine Model

Human Multipotent Stem Cell Proteins Support Soft Tissue Regeneration

Engineering a Pre-Metastatic Niche as a Sensor for Early Cancer Detection

Translational Landscape and the California Institute for Regenerative Medicine

10:15 - 10:30 AM

Anthony Awojoodu

Molly Ogle Zegbeh Jallah Manu Platt Jane Lebkowski



University of Pittsburgh Georgia Institute of Technology

Regenerative Patch Technologies

In Vivo Hypoxia Detection with a Nanofiber Scaffold

Tuning Monocyte Recruitment and Phenotype through Sphingosine-1-Phosphate Receptors

Investigating the Potential of Urinary Bladder Matrix (Acell®) to Obviate Vaginal Smooth Muscle and Nerve Degeneration Following Implantation with Polypropylene Mesh

The Direct Osteolytic Potential of MCF-7 and MDA-MB-231 Breast Cancer Cells in an In Vitro Bone Environment

Engineered Embryonic Stem Cell Derived Implant to Treat Retinal Disease

1918

DAY 4 - WEDNESDAY, NOVEMBER 13, 2013 DAY 4 - WEDNESDAY, NOVEMBER 13, 2013

11:30 AM Lunch BreakMeeting Room


10:30 - 10:45 AM

Laura Ricles Sittadjody Sivanandane

Tanushree Thote Eliza Fong Jane Lebkowski

The University of Texas at Austin

Wake Forest University School of Medicine


Rice University Continued

Gold Nanoparticle Monitoring of Mesenchymal Stem Cells for In Vivo Applications Related to Ischemic Repair

Restoring Bone Metabolism in an Ovarian Failure Model Using a Tissue Construct-Based Hormone Replacement Therapy

Micronized Amnion ECM as a Tissue Engineering Based Intervention for OA

Developing a Clinically Relevant In Vitro Model of Bone Metastatic Prostate Cancer

Engineered Embryonic Stem Cell Derived Implant to Treat Retinal Disease

10:45 - 11:00 AM

Xinping Zhang Samer Zaky Adam Young Seema EhsanUniversity of Rochester Medical Center

Center for Craniofacial Regeneration

University of California, San Diego


Intravital Imaging of Osteogenesis and Angiogenesis in Repair and Regeneration

Osteo Conductivity of a Load- transducing Elastomer is Enhanced by Recruited Periosteal Rather than Loaded Osteoprogenitors

Injectable Adipose ECM Hydrogels Stimulate Neovascularization and Subsequent Adipose Regeneration

A Three-Dimensional in Vitro Model of Vascularized Human Tumor Tissue

11:00 - 11:15 AM

Eva Brauchle Maria Coronel Adam Taylor Chien-Chi Lin Steven SticeFraunhofer IGB University of Miami University of

NottinghamIndiana University-Purdue University Indianapolis

University of Georgia

Raman Spectroscopy on the Cardiovascular Commitment and Cardiac Phenotypes of Mouse Embryonic Stem Cells Differentiated toward the Cardiovascular Fate

Downregulation of Hypoxia Induced Apoptotic Pathways in Pancreatic Islets via Oxygen Generating Biomaterial

Decellularized Matrices from a Pro-Inflammatory Environment: Surface Analysis and Cell Response

Synergistic Effect of Extracellular Cues on Growth Inhibition of Human Pancreatic Ductal Adenocarcinoma Cells in 3D

Using Differentiated Cell Types from Pluripotent Stem Cells to Model Normal and Diseased Tissues for Drug Development

11:15 - 11:30 AM

Lizhi Cao Bruce Bunnell Sean Murphy Susan ThomasGeorgia Institute of Technology

Tulane University Wake Forest University Georgia Institute of Technology

A Conformation Specific Antibody Against Fibronectin: Applications for Imaging of the Ecm for Tissue Engineering

Adult Stem Cells from Adipose Tissue and Bone Marrow Ameliorate the Symptoms of Experimental Autoimmune Encephalomyelitis

Amnion Hydrogel Accelerates Skin Wound Healing

Building a Cancer Nanotherapeutic Exploiting Tumor Immuno Pathophysiology

Meeting Room


Session 2: 1:00-2:30

Manufacturing Platform Technologies

Immuno-modulation

Remodeling & Repopulation of Acellular Matrices

Pre-clinical Animal Models

Early Translation of Tissue Engineered Combinations Products

Session Chairs

John Fisher Dolores Baksh Karen Christman Jennifer Elisseeff Rahul Thakar

Masahiro Kino-oka Ned Waller Shay Soker Wan-Ju Li Kevin WhittleseyStudent

Co-ChairZohreh Izadifar Adam Young Abritee Dhal Mahsa Mohiti

1:00 - 1:15 PM

Masahiro Kino-oka Edmund Waller Stephen Badylak Dietmar Hutmacher Alfred Lane Osaka University Emory University University of

PittsburghQueensland University of Technology

Stanford University

Automation System for Cell Processing Based on the Flexible Modular Platform

Enhancing Adaptive Anti-Tumor Immune Responses by Modulating VIP Signaling

A Biologic Scaffold Approach to Promote Functional Skeletal Muscle in Patients with Volumetric Muscle Loss

Delayed Cell Injection of Allogenic Mesenchymal Progenitor Cells for Bone Regeneration in an Ovine Critical-Sized Segmental Tibial Bone Defect

Cell-based Therapy for a Lethal Genetic Skin Disease

1:15 - 1:30 PM

Akon Higuchi Jaime Giraldo Vahid Serpooshan Salim DarwicheNational Central University

University of Miami Stanford School of Medicine

Ecole Polytechnique Federale de Lausanne

The Isolation and Differentiation of Human Adipose-Derived Stem Cells Using Membrane Filtration Method

Combination of Cell Surface PEGylation and Short-Course Immunotherapy for Prolonged Survival of Pancreatic Islets in an Allogeneic Murine Model

Engineered Epicardium Activates Cardiac Regeneration

Autologous Matrix Induced Chondrogenesis Combined with Epiphyseal Chondro-Progenitor Cells for the Treatment of Full Thickness Cartilage Injuries - an Experimental GLP-grade Safety Study in Goats

1:30 - 1:45 PM

Shashi Murthy Sangeetha Srinivasan

Elizabeth Calle Young Min Ju Sophie Deng



Yale University Wake Forest School of Medicine

University of California, Los Angeles

Microfluidic Isolation of Epidermal Skin Stem Cells Enables Hair Growth in Nude Mice

Biomaterial-Based Engineering of Dendritic Cell Environments for Tolerance Induction

Regenerative Capacity of Distal Epithelium Cultivated in a Decellularized Lung Extracellular Matrix Scaffold

In Vivo Evaluation of Electrospun Bilayered Vascular Scaffold for Engineering Small Diameter Blood Vessels

Engineering Replacement Cornea from Autologous Stem Cells

2120

Meeting Room


1:45 - 2:00 PM

Hyun-Wook Kang Gustavo Garlet James Williams Mon Tzu Li Sophie DengWake Forest School of Medicine

Faculdade de Odontología de Bauru - Universidade de São Paulo

Wake Forest Health Sciences

Georgia Institute of Technology & Emory University

Continued

3-D Bioprinting of Innervated Skeletal Muscle Tissue for Accelerated Restoration of Muscle Function

Therapeutic Arrest of Experimental Periodontitis Progression by CCL22 is Mediated by a CCR4-Dependent Regulatory T Cells Chemoattraction

Antibody-Directed Cellularization of Heart Valve Implants

Novel Volumetric Muscle Loss Model in the Rat Biceps Femoris for Screening of ECM-Derived Scaffolds

Engineering Replacement Cornea from Autologous Stem Cells

2:00 - 2:15 PM

Yuan Pang Tracy Ooi Bryan Brown Franklin West Scott Burger, Alfred Lane, Sophie DengUniversity of Tokyo University of Texas

at AustinUniversity of Pittsburgh University of

GeorgiaEngineering an Implantable Liver Construct based on Perfusion Culture of Cellular Aggregates in Scalable Three-dimensional Scaffold

Generating Antigen-Specific T Cells from Mouse and Human Stem Cells: a Bioengineering Approach

Reconstruction of the TMJ Disc Using an ECM Device in a Porcine Model of Meniscectomy

Pre-Clinical Middle Cerebral Artery Occlusion Ischemic Stroke Pig Model

Panel Discussion – Laying a Strong Foundation for Translation of Regenerative Medicine Research

2:15 - 2:30 PM

Katsuhisa Matsuura Cynthia Giver Robert Tranquillo Alexander BaileyTokyo Woken’s Medical University

Emory University, Winship Cancer Institute

University of Minnesota Food and Drug Administration

The Developments of Three-Dimensional Suspension Culture System for Human iPS Cells Expansion and Cardiac Differentiation

Use of Donor Plasmacytoid Dendritic Cells to Optimize Donor T-cell Activity in Allogeneic Stem Cell Transplantation

In Vivo Remodeling of Decellularized, Completely-Biological Tissue-Engineered Arterial Grafts

Evaluation of Tumorigenicity for Cell-based Regenerative Medicine Products: a Retrospective Review of CBER/OCTGT Experience 2006-2011

2:30 PM BreakSession 3: 3:00-4:30

Rejuvenation of Tissue & Organ Function

Paracrine Factor Effects

Public Policy Polytrauma Models

Pathway to the Clinic with Regenerative Medicine Products

Session Chairs

Robert Christy Eben Alsberg Aaron Levine David Baer Rahul Thakar

Marsha Rolle Kacey Marra Mark Hamrick Kevin WhittleseyStudent

Co-ChairSarah Griffiths CW Jenny Chang Jinah Jang Etai Sapoznik

Meeting Room


3:00 - 3:15 PM

Rameshwar Rao Ranieri Cancedda Paul Wolpe Benjamin Corona Scott Burger University of Michigan

University of Genova Emory University

United States Army Institute of Surgical Research

Advanced Cell and Gene Therapy

Dual-Phase Osteogenic and Vasculogenic Engineered Tissue for Bone Formation

Mesenchymal Stem Cells (MSC) Induce the Homing of Endogenous Progenitor Cells through the Activation of Alternatively Activated Macrophages in an Ectopic Bone Formation Model

From Live Donor to Live Recipient: The Ethics of Tissue Research as a Therapeutic Bridge

Impaired Musculoskeletal Healing in a Rat Composite Injury Model

Regulatory and Manufacturing Considerations for Regenerative Medicine Products

3:15 - 3:30 PM

In Kap Ko Scott BurksWake Forest School of Medicine

National Institutes of Health Clinical Center

CD31 Antibody Conjugation Improves Re-endothelialization of Acellular Kidney Scaffolds for Whole Organ Engineering

Noninvasive Targeting of Mesenchymal Stem Cells (MSC) to Kidneys by Clinically-Relevant Pulsed Focused Ultrasound Enhances Both Protective and Regenerative Capabilities of MSC in a Murine Model of Cisplatinum-Induced Acute Kidney Injury

3:30 - 3:45 PM

Laura Struzyna Joel Wise Jason Robert Nick Willett Karen Christman University of Pennsylvania

University of Michigan Arizona State Georgia Institute of Technology

UCSD

Tissue Engineered Grafts Accelerate Peripheral Nerve Repair by Direct Axon-Induced Axon Regeneration

Delivery of a Combination of Fresh Marrow Cells and Purified Mesenchymal Stem Cells within Collagen-Chitosan Microbeads Enhances Ectopic Bone Formation

From Bench to Clinic: Challenges and Opportunities

Composite Bone and Muscle Injury Attenuates Revascularization of a Segmental Bone Defect

Injectable Extracellular Matrix-Derived Hydrogel for Treating Myocardial Infarction

3:45 -4:00 PM

Youssef Farhat Warren Gray Aaron Levine Daniel HickeyUniversity of Rochester

Georgia Institute of Technology/Emory University



TGF-β1 Decreases Plasmin-Mediated MMP Activity in Flexor Tendon Cells: Implications for Scarless Tendon Repair

Cardiac Progenitor Cells Release microRNA-Loaded Exosomes that Enhance Angiogenesis and Mitigate Hypoxic Death

Regenerative Medicine and the Challenge of Unproven Stem Cell “Therapies”

Magnesium Oxide Nanoparticles Increase Osteoblast and Fibroblast Functions on Poly(l-lactic Acid) Composites for Tendon to Bone Insertion Applications

DAY 4 - WEDNESDAY, NOVEMBER 13, 2013 DAY 4 - WEDNESDAY, NOVEMBER 13, 2013

2322

Meeting Room


4:00 -4:15 PM

Olive Mwizerwa Matthew Skiles Albert Cheng Dolores Baksh Massachusetts General Hospital

University of South Carolina Georgia Institute of Technology

Organogenesis

Engineered Skeletal Muscle for Craniomaxillofacial Reconstruction

Tuning Local Hypoxia to Impact Secretion of VEGF from ASC Spheroids

Discussion with All the Above Speakers

The Effect of Concomitant Hind Limb Ischemia on Early Vascular Growth and Gene Expression in rhBMP-2-mediated Segmental Bone Defect Repair

Lessons from a Successful FDA Review Process for an Allogeneic Cell Therapy

4:15 -4:30 PM

Hyun Ju Lim James Williams Marcello PiliaWake Forest University

Wake Forest Health Sciences United States Army Institute of Surgical Research

Donor Derived Skeletal Muscle Precursor Cells Improve Muscle Functions in a Murine Model of X-Linked Myotubular Myopathy

A Comparison of Cellular and Acellular (Chemokine) Therapy in a Primate Model of Urinary Sphincter Deficiency

Transplantation of Microvascular Fragments in an Experimental Volumetric Muscle Loss Model

4:30 -5:00 PM

Closing Ceremony - Centennial III

SYIS-AM Poster Awards Presentations - Rebecca Dahlin, SYIS-AM Chair and Tracy Hookway, SYIS-AM Vice-Chair

TERMIS-AM Membership Business Meeting (We invite everyone to attend!) - Chaired by: Robert E. Guldberg, PhD, TERMIS-AM Chair

DAY 4 - WEDNESDAY, NOVEMBER 13, 2013 POSTER SESSION I – MONDAY, NOVEMBER 11, 2013 4:30 – 6:00 PM

DRUG DELIVERY PRINCIPLES

100Riccardo GottardiAutologous Stem Cell Recruitment for Articular Cartilage RegenerationRiccardo Gottardi (1); Mintai Peter Hwang (2); Matthew Simson (3); Paul A. Manner (4); Jian Tan (5); Peter G. Alexander (6); Steven R. Little (7); Rocky S. Tuan (8)Department of Orthopaedic Surgery, School of Medicine, University of Pittsburgh (1); Ri.MED Foundation (2); Department of Chemical and Petroleum Engineering, University of Pittsburgh (3); Department of Bioengineering, University of Pittsburgh (4); Department of Mechanical Engineering and Materials Science, University of Pittsburgh (5); Department of Immunology, University of Pittsburgh (6); The McGowan Institute for Regenerative Medicine, University of Pittsburgh (7); Department of Orthopedics and Sports Medicine, University of Washington (8)

101Esmaiel JabbariSequential Release of VEGF and BMP2 Proteins in PEG-Based Hydrogel MicropatternsUniversity of South Carolina, Columbia, South CarolinaSeyedsina Moeinzadeh, Danial Barati, Esmaiel Jabbari

102Ronald Jiménez CruzOptimization of Collagen I Scaffolds by Incorporating Microgels for Controlled Release of a Calendula Officinalis Extract Ronald Jiménez (1); Diana Millán (2); Edward Suesca (3); Marta Fontanilla (4);Tissue Engineering Group, Department of Pharmacy

103Makoto KomuraPromotion of Tracheal Cartilage Growth by Intra-tracheal Administration of Basic Fibroblast Growth Factor (b-FGF)Makoto Komura (1,2); Hiroko Komura (1); Kenichirou Konishi (1)Department of Pediatrics Surgery, School of Medicine, Saitama Medical University (1); Department of Pediatric Surgery, Graduate School of Medicine, University of Tokyo (2)

104Weiping Ren Release of Doxycycline Loaded in Polycaprolactone/Polyvinyl Alcohol Nanofibers for Implant Infection Wei Song (1); David C Markel (2,3); Weiping Ren (1,3) Department of Biomedical Engineering, Wayne State University, Detroit, Michigan (1); Detroit Medical Center & Providence Hospital Orthopaedic Residency, Detroit, Michigan (2); Department of Orthopaedic Surgery, Providence Hospital, Southfield, Michigan (3)

105Won Hyuk SuhNanostructured Biomaterials for Stem Cell EngineeringBioengineering Department, Temple University

106Michael ToPrecisely Investigating Physical Changes of PLGA Microspheres during Drug Release Process using Monodisperse MicrospheresJun Wu (1), Kelvin W.K. Yeung (2), Anderson Shum (3), Michael K.T. To (4)Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong; Department of Mechanical Engineering, Faculty of Engineering, The University of Hong Kong

107Anup TuladharLocal Delivery of Cyclosporine to the Brain for Endogenous Neural Stem Cell Stimulation after StrokeInstitute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada (1); Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada (2); Department of Surgery, University of Toronto, Toronto, Ontario, Canada (4)

108Jun WuPrecisely Investigating Physical Changes of PLGA Microspheres during Drug Release Process using Monodisperse MicrospheresJun Wu; Kelvin WK Yeung; Michael KT ToOrthopaedics & Traumatology, LKS Faculty of Medicine, The University of Hong Kong

ENGINEERING MORPHOGENESIS

109Luis AlonzoA Dual-Chamber Microfluidic Device to Study the Effects of Interstitial Flow in Tumor AngiogenesisLuis Alonzo (1,2); Monica Moya (1,2); Marian Waterman (3,4); Chris Hughes (1,2,5); Steven George (1,2,6)Biomedical Engineering, University of California Irvine (1); Edwards Lifesciences Center for Advanced Cardiovascular Technology (2); Microbiology and Molecular Genetics, University of California Irvine (3); Cancer Research Institute Research Centers and Institutes, University of California, Irvine (4); Molecular Biology and Biochemistry, University of California, Irvine (5); Chemical Engineering and Material Science, University of California, Irvine (6)

110Shruti BalajiPdx1 And Epidermal Growth Factor Induce Pancreatic Ductal Gene Expression In Human Amnion Epithelial Cells In VitroShruti Balaji (1,2); Yu Zhou (1); Anasuya Ganguly (2); Emmanuel C Opara (1); Shay Soker (1)Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Health (1); Department of Biological Sciences, Birla Institute of Technology & Sciences-Pilani, K.K. Birla Goa Campus (2)

111James DennisTissue Engineering of an Epithelialized Scaffold-free NeotracheaTanya K. Meyer (2); Kristina G. Bernardi (2);Thomas J. Kean (2); James E. Dennis (2)Otolaryngology, University of Washington, Seattle, WA (1); Hope Heart and Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington (2)

112Chandrasekhar KothapalliSpatio-temporal Diffusion of Biomolecular Gradients within 3D Scaffolds Regulate Neurite Outgrowth and TurningMichael A. Sawonik, Chandrasekhar R. KothapalliDepartment of Chemical & Biomedical Engineering, Cleveland State University, Cleveland, Ohio

113Kellin KrickNeurotrophic Factor Gradient Presentation for Migration Guidance of Human Schwann CellsKellin D. Krick (1); Yu-Ja Huang (2); Russell Martin (2); Peter C. Searson (2); Ali Khademhosseini (3); Ahmet Hoke (4); Hai-Quan Mao (2)Biomedical Engineering, Johns Hopkins School of Medicine (1); Materials Science and Engineering, Johns Hopkins University (2); Health Sciences and Technology, Harvard-MIT (3); Neurology and Neuroscience, Johns Hopkins School of Medicine (4)

114Rutwik RathRole of Cardiac Maturation in Cell Alignment as a Function of Matrix Fiber SpacingRutwik Rath (1); Douglas B. Sawyer (2); Hak-Joon Sung (1,2);Department of Biomedical Engineering, Vanderbilt University (1); Division of Cardiovascular Medicine, Vanderbilt University (2)

115Robert SchrammLabel-Free Electrochemical Detection of Salivary Gland Protein Products Enables Rapid Characterization for In-Vitro Tissue EngineeringRobert A. Schramm (1); David A. Soscia (1); Kavitha Jayarathanam (1); Sharon J. Sequeira (2); James Castracane (1); Melinda Larsen (2)College of Nanoscale Science and Engineering (1), State University of New York; Biological Sciences, University at Albany (2)

116Raymond SwetenburgTowards a Model for Motor Neuron Derivation from Pluripotent Stem CellsRaymond L. Swetenburg (1); Douglas E. White (2,3); Erin T. Jordan (1); Melissa L. Kemp (2,3); Todd C. McDevitt (2,3); Steven L. Stice (1)Regenerative Bioscience Center, The University of Georgia, Athens, Georgia (1); The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, Georgia (2); The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia (3)

ENGINEERING OF MATRIX COMPOSITION

117Jean-Michel BourgetDevelopment of a Microstructured Scaffold Made from Fibroblast-Derived ECM to Produce a Tissue-Engineered Vascular MediaJean-Michel Bourget (1,2); Véronique Laterreur (1,3); Maxime Guillemette(1,2,4); Robert Gauvin (1,5); Caroline Miville-Godin (6); Maxence Mounier (6); Jean Ruel (3); François A. Auger (1,2); Teodor Veres (6), Lucie Germain (1,2)LOEX - Centre de recherche FRQS du Centre hospitalier universitaire (CHU) de Québec, Canada (1); Département de Chirurgie, Faculté de Médecine, Université Laval, Québec, QC, Canada (2); Le bureau de design, Département de génie mécanique, Faculté des sciences et de génie, Université Laval (3); Département de Physique, Faculté des sciences et de génie, Université Laval and Biomedical Engineering Department, Quebec Heart and Lung Institute, Québec, Canada (4); Quebec Center for Functional Materials (CQMF), Université Laval, Canada (5); Life Sciences Division, Biomedical Engineering, McGill University, National Research Council Canada, Boucherville, Canada (6)

118Valérie BrunIn Vitro and In Vivo Evaluation of Chitosan/Hydroxyapatite Hybrid Matrices for Optimized Bone RegenerationValérie Brun (1); Christine Guillaume (1); Richard Gouron (2); Romuald Mentaverri (2); Sylvie Bouthors(1); Dominique Laurent-Maquin (1); Sophie Gangloff (1); Halima Kerdjoudj (1); Frédéric Velard (1)(1) EA 4691 BIOS, SFR Cap-Santé (FED4231), University of Reims Champagne-Ardenne (2) INSERM UMR-S1088, SFR Cap-Santé (FED4231), University Picardie Jules Verne

119Lisa CareyIn vivo Degradation of Porcine Dermal Extracellular Matrix: A Quantitative StudyLisa E. Carey (1); Christopher Dearth (2); Scott Johnson (3); Stephen F. Badylak (4)McGowan Institute for Regenerative Medicine, University of Pittsburgh (1); Department of Bioengineering, University of Pittsburgh (2); Department of Surgery, University of Pittsburgh (3)

120Chia-Wei ChangCharacterization of Porcine SIS ECM Seeded with Human MSCs for Cardiac Tissue EngineeringChia-Wei J Chang (1); Tye Petrie (2); Claus Sondergaard (2); Leigh G. Griffiths (1)Veterinary Medicine & Epidemiology, University of California - Davis (1); Department of Surgery, University of California - Davis (2)

121Rebecca DahlinEnhancing the Chondrogenic Phenotype of Articular Chondrocytes in Flow PerfusionRebecca L. Dahlin; Ville V. Meretoja; Mengwei Ni; F. Kurtis Kasper; Antonios G. MikosBioengineering, Rice University

2524

POSTER SESSION I – MONDAY, NOVEMBER 11, 2013 4:30 – 6:00 PM POSTER SESSION I – MONDAY, NOVEMBER 11, 2013 4:30 – 6:00 PM

122George FercanaBioactive Scaffolds for Peripheral Vascular SurgeryGeorge R. Fercana (1); Devon A. Bowser (1); Eugene M. Langan III (2); Christopher G. Carsten III (2); Dan T. Simionescu (1)Bioengineering, Clemson University (1); Department of Surgery, Greenville Health System (2)

123Kimberly FerlinProtein-Modified PEGDA Hydrogels Increase Mesenchymal Stem Cell Adhesion and SpreadingKimberly M. Ferlin (1); David S. Kaplan (2); John P. Fisher (1)Fischell Department of Bioengineering, University of Maryland - College Park (1); Center for Devices and Radiological Health, Food and Drug Administration (2)

124Paulomi GhoshIn vitro and In Vivo Biocompatibility of Ionically Crosslinked Chitosan Micro/Nano Fibers for Tissue Engineering ApplicationsPaulomi Ghosh; Arunprabhu Rameshbabu; Santanu DharaSchool of Medical Science and Technology, Indian Institute of Technology, Kharagpur

125Erik HadleyCompletely Defined Pluripotent Stem Cell Culture Using mTeSR™1 and TeSR™-E8™ Maintenance Media with Vitronectin XF™Erik B. Hadley (1); Mandy Chan (1); Rachel Liu (1); Jessica Norberg (1); Allen C. Eaves (1,2); Terry E. Thomas (1); Sharon A. Louis (1)STEMCELL Technologies Incorporated, Vancouver, British Columbia, Canada (1); Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada (2)

126Henk HoogenkampInduction of Shape Memory in Collagen Scaffolds by Chemical Crosslinking under Physical RestrainmentHenk Hoogenkamp (1); Luuk Versteegden (1); Dorien Tiemessen (2); Egbert Oosterwijk (2); Willeke F. Daamen (1); Toin H. van Kuppevelt (1)Department of Biochemistry, Radboud University Medical Centre (1); Department of Urology, Radboud University Medical Centre (2)

127Esmaiel JabbariOsteogenic Differentiation of Stromal Cells in Cortical-Bone-Mimetic MicrotubesOzan Karaman; Esmaiel JabbariUniversity of South Carolina, Columbia, South Carolina

128Bryant MennUltra-low Crosslinked Microgels Create Bimodal Pore Sizes in Fibrin Extracellular Matrices - Implications in Tissue EngineeringBryant Y. Menn (1); Alison M. Douglas (1); L. Andrew Lyon (2,3); Thomas H. Barker (1,3)Biomedical Engineering, Georgia Institute of Technology (1); Chemistry and Biochemistry, Georgia Institute of Technology (2); Bioengineering and Biosciences, Georgia Institute of Technology (3)

129Anja MetznerComparison of Two Different Decellularization Methods for Tissue Engineering of Pulmonary Heart ValvesJessica Boldt; Georg Lutter; Huangdong Dai, Martin Marczynski-Buehlow, Beke Sarrahs, Jan Schoettler; Jochen Cremer; Anja MetznerDepartment of Cardiovascular Surgery, Christian-Albrechts-University of Kiel, School of Medicine, Kiel, Germany

130Harsh PatelComprehensive Study of Three Different PCL: PGC Tubular Scaffolds for Potential Vascular Graft ApplicationHarsh N Patel (1); Vinoy Thomas (2); Yogesh K Vohra (3)Biomedical Engineering, University of Alabama at Birmingham (1); Materials Science and Engineering, University of Alabama at Birmingham (2); Department of Physics, University of Alabama at Birmingham (3)

131Satyavrata SamavediAn Electrospun Mesh Possessing Region-wise Differences in Fiber Alignment for the Potential Regeneration of Bone-Ligament TransitionsSatyavrata Samavedi (1); Prudhvidhar Gaddam (1); Abby R Whittington (1,2,3); Aaron S Goldstein (1,3)Chemical Engineering, Virginia Polytechnic Institute and State University (1); Materials Science and Engineering, Virginia Polytechnic Institute and State University (2); School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University (3)

132Sumona SarkarSynergistic Effects of Scaffold Structure and Chemistry on Human Bone Marrow Stromal Cell Response to Fibrous ScaffoldsSumona Sarkar (1); Bryan A. Baker (1); Carl G. Simon Jr. (1); Joy Dunkers (1)Biosystems and Biomaterials Division, National Institute of Standards and Technology (1)

133Maria SotoIsolation of Type II Collagen from Bovine Tracheal Cartilage and Production of Scaffolds using Two Different MethodologiesMaría E. Soto (1); Sergio A. Casadiegos (1); Edward B. Suesca (1); Marta R. Fontanilla (1)Tissue Engineering Group, Laboratory 318, Department of Pharmacy,Universidad Nacional de Colombia, Bogotá, Colombia (1)

134Patrick ThayerCylindrical Composite Scaffolds for Ligament Tissue EngineeringPatrick S. Thayer (1); Aaron S. Goldstein (1,2)School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University (1); Department of Chemical Engineering, Virginia Polytechnic Institute and State University (2)

135Prasad VaidyaFITC-BSA Loaded Chitosan/PLL Alginate Microspheres in Electrospun ScaffoldPrasad Vaidya (1); Aaron Goldstein (2)Chemical Engineering Department, Virginia Polytechnic Institute and State University

ENGINEERING TISSUES FOR IN VITRO SCREENING & DIAGNOSTICS

136Pedro BaptistaRecapitulation of Human Liver Embryonic Development on Decellularized Liver MatrixPedro M. Baptista (1); Dipen Vyas (1); Emma Moran (1); Anthony Atala (1); Shay Soker (1)Wake Forest Institute of Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina(1)

137Mariea BradyIntegration of an Automated Perfusion System into a High-throughput Magneto-Mechanostimulation Device for Cartilage Tissue EngineeringMariea A Brady (1); Xiaoming Shi (1); Reva Vaze (1); Harsh D. Amin (1); Darryl R. Overby (1); C. Ross Ethier (1, 2)Department of Bioengineering, Imperial College London, South Kensington, London, United Kingdom (1); Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta (2)

138Rachel CampbellFabrication of Surgically Perfusable Microchannel-Containing Tissue-Engineered ScaffoldsRachel Campbell (1); Karina A. Hernandez (1); Tatiana Boyko (1); Jeremiah Joyce (1); Kadria N. Derrick (1); Adam M. Jacoby (1); Jason A. Spector (1)Plastic Surgery, Weill Cornell Medical College (1)

139Dean ChamberlainA Modular Approach to the Development of Liver Microtissues for In Vitro Drug ScreeningM. Dean Chamberlain (1,2); Michael V. Sefton (1,2)Institute for Biomaterials and Biomedical Engineering, University of Toronto (1); Department of Chemical Engineering and Applied Chemistry, University of Toronto (2)

140Kimberly FerlinCharacterization of Chondrocyte Adhesion on Fibronectin-Coated SubstratesDavid S. Kaplan (1); Priyanka Durai (1); Kimberly M. Ferlin (2); John P. Fisher (2)Center for Devices and Radiological Health, Food and Drug Administration (1); Fischell Department of Bioengineering, University of Maryland - College Park (2)

141Petra KerscherEngineering Developing Human Heart Tissue for Investigating Mechanisms of Congenital Heart Defect FormationPetra Kerscher (1); Irene C. Turnbull (2); Blakely S. Bussie (1); Dror Seliktar (3); Kevin D. Costa (2); Elizabeth A. Lipke (1)Chemical Engineering, Auburn University, Auburn, Alabama (1); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York (2); Department of Bioengineering, Technion-Israel Institute of Technology, Technion City, Haifa, Israel (3)

142Mahsa Mohiti-AsliSkin Tissue Engineering for the Infected Wound Site: Evaluations of PLA Nanofibers and Novel Approach for Silver Ion Release in a Co-Culture System of Keratinocytes and Staphylococcus AureusMahsa Mohiti-Asli (1); Behnam Pourdeyhimi (1); Elizabeth G. Loboa (2)College of Textiles, North Carolina State University (1); Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University (2)

143Emma MoranBioengineered Liver Organoids as a Novel Platform to Model Fluid Biomechanics, Regulation of Liver Development and RegenerationEmma C. Moran (1,2); Pedro M. Baptista (2); Jessica L. Sparks (3); Shay Soker (1,2)Virginia Tech-Wake Forest School of Biomedical Engineering and Science, Wake Forest University (1); Wake Forest Institute for Regenerative Medicine, Wake Forest University (2); Chemical and Paper Engineering, Miami University (3)

144Bao-Ngoc NguyenEffect of Culturing Location of Human Mesenchymal Stem Cells in Tubular Perfusion System Bioreactor on Osteogenic DifferentiationBao-Ngoc B. Nguyen (1); Henry Ko (1); John P. Fisher (1)Fischell Department of Bioengineering, University of Maryland - College Park (1)

145Three-Dimensional Organoid Systems for Modeling Colon Carcinoma Metastasis and Anti-Cancer Drug DevelopmentAleksander SkardalAleksander Skardal (1); Mahesh Devarasetty (1); Shay Soker (1)Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine (1)

146Maria StancescuIn Vitro Platform for Pharmacological Cardiac Side Effects TestingMaria Stancescu (1); Peter Molnar (2,3); James J. Hickman (1)NanoScience Technology Center, University of Central Florida (1); Department of Zoology, University of West Hungary (2); Biomedical Engineering, Cornell University (3)

147Stephanie TeeterPDLIM4 and Corin are Key Regulators of hMSC Osteogenesis and Terminal Differentiation in Hypoxic ConditionsStephanie Teeter (1); Adisri Charoenpanich (1); Elizabeth Loboa (1)Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina at Chapel Hill (1)

148Brian WileMolecular Beacons as a Tool to Separate Cardiomyocytes from Differentiating Pluripotent Stem CellsBrian Wile (1); Kiwon Ban (2); Sangsung Kim (2); Jaemin Byun (2); Talib Saafir (3); Mary Wagner (3); Young-sup Yoon (2); Gang Bao (1)Biomedical Engineering, Georgia Institute of Technology and Emory University (1); Cardiology, Emory University (2); Pediatrics, Emory University (3)

149Ling WuFunctional Cell Sorting Based on Extracellular Matrix Domain Detection (EMDD)Ling Wu (1); Frank A. Petrigliano (1); David R. McAllister (1); John S. Adams (1,2,3); Paul D. Benya (1); Denis Evseenko (1,2,3)Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles (1); University of California, Los Angeles, Broad Stem Cell Institute for Regenerative Medicine and Stem Cell Research (2); University of California, Los Angeles, Jonsson Comprehensive Cancer Center (3)

150Bin YangParacine Trophic Effect and Cell Differentiation of Human Urine-Derived Stem Cells Seeded on 3D Porous Scaffold for Potential Application in Ureter Tissue RegenerationBin Yang; Guihua Liu; Rongpei Wu; Lujie Song; Anthony Atala; Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina

INTERFACING REGEN MED WITH ‘OMICS

151Bryan BakerThe Effects of Scaffold Morphology on Gene Expression Profiles of Primary Human Bone Marrow Stromal CellsBryan A. Baker (1); P. Scott Pine (1); Girish Kumar(1,2); Kaushik Chatterjee (1,3); Jennifer H. McDaniel (1); Mark L. Salit (1); Carl G. Simon Jr. (1)Biosystems & Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, Maryland (1); Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food & Drug Administration, Silver Spring, Maryland (2); and Department of Materials Engineering, Indian Institute of Science, Bangalore, India (3)

152Mona ElRefaeyNutrient Activation of Distinct Signaling Pathways in Bone Marrow Mesenchymal Stem Cells is Dependent on Oxygen PressureMona ElRefaey (1,2); Qing Zhong (1,2,3); Xingming Shi (1,2,4); William Hill (1,2,4); Yun Su (2) Lakiea Bailey (1,2); Norman Chutkan (6) Ke-Hong Ding (1,2,3); Wendy Bollag (2,7); Mark Hamrick (2,5,6); Carlos Isales (1,2,6);Institute of Molecular Medicine and Genetics, Georgia Regents University (1); Institute for Regenerative and Reparative Medicine, Georgia Regents University (2); Department of Medicine (3); Department of Pathology, Georgia Regents University (4); Department of Cellular Biology and Anatomy, Georgia Regents University (5); Department of Orthopaedic Surgery, Georgia Regents University (6); Department of Physiology, Georgia Regents University (7)

153Laura MarquardtEffect of GDNF on Schwann Cell Phenotypes and Role in Neurite OutgrowthLaura M. Marquardt (1); Shelly E. Sakiyama-Elbert (1)Biomedical Engineering, Washington University in St. Louis (1)

154Eun Jin SonGene Expression Patterns during Development of Cochlear TonotopyEun Jin Son (1)Department of Otorhinolaryngology, Yonsei University College of Medicine, Gangnam Severance Hospital (1)

MECHANOTRANSDUCTION

155Dekel Dado-RosenfeldExternal Forces Applied on Embryonic Stem Cells in 3D Can Direct Early Differentiation Toward a Specific Germ LayerDekel Dado-Eosenfeld (1); Shulamit Levenberg (1)Biomedical Engineering Department, Technion Israel Institute of Technology, Israel (1)

156Christopher DearthMechanical Loading/Rehabilitation as a Determinant Factor in Constructive Remodeling of Biologic ScaffoldsChristopher Dearth (1,2); Christian Ranallo (1); Michael Kochis (1); Brian Sicari (1); Edward Garay (1,3); Stephen Badylak (1,2,4)McGowan Institute for Regenerative Medicine, University of Pittsburgh (1); Department of Surgery, University of Pittsburgh (2); Department of Physical Medicine & Rehabilitation, University of Pittsburgh (3); Department of Bioengineering, University of Pittsburgh (4)

157Kyle EdmundsInvestigation of Cardiomyocyte Proliferation on Fractionated Cardiac Extracellular Matrix Derived from Perfusion-Decellularized Ventricular TissueKyle J. Edmunds (1); Corin Williams (1); Ngonidzashe Madungwe (1); Lauren D. Black III (1,2)Biomedical Engineering, Tufts University (1); Biomedical Sciences, Sackler School of Graduate Biomedical Sciences (2)

158Kristin FrenchCardiac Progenitor Cells are Sensitive to Tensile Strain and Matrix CompositionKristin M. French (1); Marcos J. Fierro (1); Todd D. Johnson (2); Karen L. Christman (2); Michael E. Davis (2)Biomedical Engineering, Emory University (1); Bioengineering, University of California San Diego (2)

159Fiona GriffinAdhesion Junctions Regulate the Cytoskeletal Response to Fluid Flow StimulusFiona E. Griffin (1); Muriel C. Voisin (1); Matthew G. Haugh (1); Peter Owens (2); Patrick J. McGarry (1); Laoise M. McNamara (1)Biomechanics Research Centre (BMEC), National University of Ireland, Galway, Ireland (1); Centre for Microscopy and Imaging, National University of Ireland, Galway, Ireland (2)

160Sarah GriffithsEndothelial Associated Shear Sensitive Genes and Epigenetic Profiles in Mesenchymal Stem CellsSarah Griffiths (1); Yunzhe Zhang (1); Yuhong Fan (1); Robert Nerem (1)Institute of Bioengineering and Bioscience, Georgia Institute of Technology (1)

161Greg HarrisDiscriminating the Influence of Cell Shape and Matrix Elasticity on Mesenchymal Stem Cell Lineage CommitmentGreg M. Harris; Ehsan Jabbarzadeh Chemical Engineering, University of South Carolina

162Esmaiel JabbariEffect of Matrix Compressive Modulus on Zonal Marker Expression of Stromal Cells in ChondrogenesisOzan Karaman (1); Sinan Guven (2); Ryan Porter (3); Christopher H. Evans (3); Utkan Demirci (2); Esmaiel Jabbari (1)University of South Carolina, Columbia, South Carolina (1); Brigham and Women’s Hospital, Boston, Massachusetts (2); Beth Israel Deaconess Medical Center, Boston, Massachusetts (3)

163Sebastien MegheziStatic Maturation Allows Smooth Muscle Cells to Effectively Remodel Collagen Gel Matrix Prior to Mechanical Stimulation in a Dynamic BioreactorSebastien Meghezi (1); Dawit G Seifu (1); Diego Mantovani (1)Laboratory for Biomaterials and Bioengineering, Laval University, Québec City, Canada (1)

164Homeyra PourmohammadaliSignificant Effect of Hydromechanical vs Mechanical Stimulation on Collagen Production of a Chondrocyte-seeded HydrogelHomeyra Pourmohammadali (1); Naveen Chandrashekar (2); John B. MedleyWaterloo Tissue Engineering Mechanics Lab, Department of Mechanical and Mechatronics Engineering, University of Waterloo (1); Waterloo Tissue Engineering Mechanics Lab, Department of Mechanical and Mechatronics Engineering, University of Waterloo (2); Waterloo Tissue Engineering Mechanics Lab, Department of Mechanical and Mechatronics Engineering, University of Waterloo (3)

165Yi-Xian QinGuided Noninvasive Acoustic Radiation Force for Promoting Bone Fracture Healing and RegenerationYi-Xian Qin (1); Long Bi (2); Maria Pritz (3)Biomedical Engineering, Stony Brook University

166Xin QuRelative Impact of Uniaxial Alignment vs. Form-Induced Stress on Differentiation of Adipose Derived Stem CellsXin Qu (1), Wei Zhu (1); Samuel Huang (2); Julie Yi-Shuan Li (2); Shu Chien (2); Shaochen Chen (1)Department of NanoEngineering, University of California, San Diego (1); Department of Bioengineering, University of California, San Diego (2)

167Bill TawilImpact of Fibroblast Growth Factor on Mesenchymal Stem Cell Osteogenic Differentiation and MigrationArmaun Emami (2); Jesus Fajardo (2); Mai Nguyen (2); Takahiro Watanabe (2); Elaheh Asghari (2); Surbhi Dutta (2); Arthela Osorio (2); Tom Velasco (2); Melissa McCoy (2); Bill Tawil (1)Department of Bioengineering, University of California, Los Angeles (1); Department of Biotechnology & Bioinformatics, California State University, Channel Islands (2)

REGENERATION-INDUCING BIOMATERIALS

168Rakhi A.A Novel Three Dimensional Nanofibrous Scaffold for Differentiation of Stem Cells into Islet like ClustersRakhi A (1); Dhanesh V (1); Bindu P. Nair (1); Prabha D. Nair (1)Division of Tissue Engineering and Regeneration Technologies, Sree Chitra Tirunal Institute for Medical Sciences and Technology (1)

169Nesreen AlsmadiAxonal Regeneration Guided by Three Dimensional Gradient of Nerve Growth FactorsNesreen Zoghoul Alsmadi (1); Parisa Lofti (1); Joselito Razal (2); Gordon Wallace (2); Mario I. Romero (1)Department of Bioengineering, University of Texas, Arlington; University of Texas Southwestern Medical Center, Dallas (1); University of Wollongong Australia, Wollongong, Australia (2)

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170Sogol BaharlouControlling Electrospun Fiber Alignment and Deposition by Using a Programmable Oscillating Auxiliary ElectrodeSogol M. Baharlou; Jonathan A. Gerstenhaber; Yah-el Har-el; Peter I. LelkesBioengineering Department, Temple University

171John BrekkeChondrogenic and Osteogenic Differentiation of hMSCs Within a Biomimetic, 3D MicroenvironmentJohn H. Brekke (1); Beth Lindborg (2); Timothy D. O’Brien (3)Bioactive Regenerative Therapeutics, Inc. (1); Stem Cell Institute, University of Minnesota (2); Comparative Medicine, Veterinary Population Medicine Department, Stem Cell Institute, University of Minnesota (3)

172Tatiana BresselEffect of Titanium Surface Modification by Laser Beam on Proliferation and Osteoblastic Differentiation of Human Mesenchymal Stem CellsTatiana A. B. Bressel (1), Jana Dara F. de Queiroz (1); Susana Moreira (1); Jéssyca T. da Fonseca (1); Edson A. Filho (2); Antônio Carlos Guastaldi (2); Silvia R. Batistuzzo de Medeiros (1)Celular Biology and Genetics Department, Universidade Federal do Rio Grande do Norte, UFRN, Natal, Brazil (1); Chemical Institute, Universidade Estadual Paulista, UNESP, Araraquara, Brazil (2)

173Brenton BurgerDevelopment of an Electrospun Poly-D-L-Lactic Acid (PDLA), Polydioxanone (PDO) and Chitin-Whiskers (CWs) Compressed, Composite Membrane for Guided Bone RegenerationBrenton W. Burger (1,2); Mark C. Bailey (1); Craig O. Yates (1); Gary L. Bowlin (1);Biomedical Engineering, Virginia Commonwealth University (1); Dulles Institute for Oral, Maxillofacial and Implant Surgery (2)

174Lian CenRegeneration of Dentin-Pulp-Like Tissue using Injectable Tissue Engineering TechniqueLinhua Tan (1,2); Lian Cen (1,2,3); Shuo Yin (2); Wei Liu (1,2); Yilin Cao (1,2)Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine (1); National Tissue Engineering Center of China (2); School of Chemical Engineering, East China University of Science and Technology (3)

175Prafulla ChandraEnhanced Tissue Regeneration using an Oxygen Producing Wound DressingPrafulla Chandra; Christina Ross; Leona Smith; Seon Jeong; Jaehyun Kim; James J. Yoo; Benjamin S. HarrisonWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina

176Alice ChengThe Effects of Combined Micro-/Nano-Roughness on Osteoblast ResponseAlice Cheng (1,2); William B. Goodwin (3); Rolando A. Gittens (4); Zvi Schwartz (5); Kenneth H. Sandhage (3); Barbara D. Boyan (1,5)Biomedical Engineering, Georgia Institute of Technology and Emory University (1); Biomedical Engineering, Peking University (2); Materials Science and Engineering, Georgia Institute of Technology (3); Bioinstrumentation and Bioengineering, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (4); Biomedical Engineering, Virginia Commonwealth University (5)

177Colin CookHierarchical Surface Topographies for Cell-Surface Interaction StudiesColin A .Cook (1); Eric Xie (1); Jason J. Benkoski (2); Warren L. Grayson (1)Biomedical Engineering, Johns Hopkins University (1); Applied Physics Laboratory, Johns Hopkins University (2)

178Elizabeth Cosgriff-HernandezChronic Wound Dressings Based on Collagen-mimetic ProteinsElizabeth Cosgriff-Hernandez (1); Brooke Russell (2); Pauline Luong (1); Mary Beth Browning (1); Anne Hocking (3); Magnus Hook (2)Texas Agricultural & Mechanical University, College Station (1); University System Health Science Center, Texas (2); University of Washington, Seattle, Washington (3)

179Catarina CustódioFunctional Cell Selective Microparticles as Injectable Cell Carriers for Tissue Engineering ApplicationsCatarina A. Custodio (1,2); Rui L. Reis (1,2); Joao F. Mano (1,2)3B’s Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Portugal (1); ICVS/3B’s, PT Government Associated Laboratory, Braga/Guimarães, Portugal (2)

180Bodhisatwa DasLaser Patterned Nano Silver Doped Calcium Phosphate Scaffolds for Bone Graft ApplicationBodhisatwa Das (1); Prabhash Dadhich (1); Pallabi Pal (1); Pavan Kumar Srivas (1); Sujoy Maiti (2); Pradeep Kumar Das Mohapatra (2); Santanu Dhara (1) School of Medical Science and Technology, Indian Institute of Technology, Kharagpur; (1); Department of Microbiology, Vidyasagar University (2)

181Christopher deBordeDevelopment of a Novel Mitral Valve Scaffold for a Tissue Engineered SolutionChristopher deBorde (1); Agneta Simionescu (2); Bioengieering, Clemson University

182Kshama DoshiGas Cluster Ion Beam Modified Collagen Leads to Rapid Differentiation and Tissue RegenerationKshama Doshi (1); Matthew Fullana (2); Gary Wnek (2); Joseph Khoury (1)Exogenesis Corporation (1); Department of Macromolecular Science and Engineering, Case Western Reserve University (2)

183Edward EbertHuman Hair Keratins Influence Proliferation and Migration of Schwann CellsKate Coniglione; Al Roth; Georges Guillaume; Ashley Jackson; James Johnson; Jacqueline Maddux; C. Edward Ebert, PhDDepartment of Chemistry and Biomedical Research Infrastructure Center, Winston Salem State University

184Martin EhrbarCell-instructive Biomaterials to Promote Bone Healing by Mesenchymal Progenitor RecruitmentPhilipp S. Lienemann (1); Vincnet Milleret (1); Anna-Sofia Kivelioe (1); Stephanie Metzger (1); Ana Sala (1); Matthias P. Lütolf (2); Martin Ehrbar (1)Department of Obstetrics, University Zurich, Switzerland (1); Laboratory of Stem Cell Bioengineering, Ecole Polytechnique Federale de Lausanne, Switzerland (2)

185Mindy EzraDevelopment of Transplantable Tissue Engineered Nerve Grafts Consisting of Stretch-Grown Axons From SwineMindy I. Ezra; John A. Wolf; Kevin D. Browne; Harry C. Ledebur; D. Kacy Cullen; Douglas H. SmithDepartment of Neurosurgery, School of Medicine, Center for Brain Injury and Repair, University of Pennsylvania

186Behzad FarshidTowards Nanoparticle Reinforced Biodegradable Composites: Cytocompatibility of Inorganic Polypropyelene Fumarate NanocompositesBehzad Farshid; Gaurav Lalwani; Balaji SitharamanDepartment of Biomedical Engineering, Stony Brook University

187Sunil GeorgeThe Feasibility of Using Autologous Renal Cells From Diseased Kidneys for the Treatment of Renal FailureSunil K. George; Mehran Abolbashari; Cheil Kim; John Jackson; Tamer Aboushwareb; Anthony Atala; James J. YooWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina

188Flavia GoncalvesUse of Co-polymer of PLLA and Poly-(isosorbide succinate) on the Development of Electrospinning ScaffoldsFlavia Gonçalves (1); Ricardo Bentini (1); Ana Claudia O Carreira (2); Patricia M Kossugue (2); Erik Halcsik (2); Mari Cleide Sogaya (2); Luiz H Catalani (1)Departamento de Química Fundamental, Instituto de Química da Universidade de São Paulo (1); Departamento de Bioquímica, Instituto de Química da Universidade de São Paulo (2)

189Yah-el Har-elElectrospun Protein Scaffolds Improve Healing in a Pig Full Thickness Skin Excision Wound ModelYah-el Har-el (1); Ross Brodsky(1); Jonathan A. Gerstenhaber (1); Richard B. Huneke (2); Peter I. Lelkes(1)Bioengineering, Temple University (1); Microbiology and Immunology, Drexel University College of Medicine (2)

190Samuel HerbergSuboptimal Bone Morphogenetic Protein-2 / Stromal Cell-Derived Factor-1β Co-Therapy Induces Bone in Critical- Size Rat Calvarial DefectsSamuel Herberg (1,3); Cristiano Susin (2,4,6); Manuel Pelaez (2); R. Nicole Howie (4); Rubens Moreno de Freitas (2); Jaebum Lee (2,4); Maribeth H. Johnson (5); Mohammed E. Elsalanty (4,8); Mark W. Hamrick (3,6,7,8); Carlos M. Isales (3,6,7,8); Ulf M.E. WikeCharlie Norwood Veterans Administration Medical Center, Augusta, Georgia (1); Laboratory for Applied Periodontal & Craniofacial Regeneration (2); Departments of Cellular Biology and Anatomy (3); Oral Biology (4); Biostatistics and Epidemiology (5); Orthopaedic Surgery (6); and Institutes of Molecular Medicine and Genetics (7); and Regenerative and Reparative Medicine (8); Georgia Regents University, Augusta, Georgia

191Alexander HodgeNitric Oxide Donors Improve Maturation of Stem Cell-derived CardiomyocytesAlexander J. Hodge (1); Juming Zhong (2); Dror Seliktar (3); Elizabeth A. Lipke (1)Chemical Engineering, Auburn University (1); Veterinary Medicine, Auburn University (2); Biomedical Engineering, Technion-Israel Institute of Technology (3)

192Sharon HyzyMSCs Secrete Pro-Inflammatory Interleukins in Response to Bone Morphogenetic Protein 2 on Microstructured TitaniumSharon L. Hyzy (1); Sarah Ortman (2); Barbara D. Boyan (1); Zvi Schwartz (1,3); Rene Olivares-Navarrete (1)Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia (1); Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia (2); Department of Periodontics, University of Texas Health Science Center at San Antonio, Texas (3)

193Claire JeongOptimized Design of Hyaluronic Acid (HA)-Poly(ethylene glycol) (PEG) Composite Hydrogels for Intervertebral Disc Tissue RegenerationClaire G. Jeong (1); Zhenbin Niu (2); Robert Mancino (1); Aubrey T. Francisco (1); Stephen L. Craig (2); Lori A. Setton (1)Biomedical Engineering & Orthopaedic Surgery, Duke University, Durham, North Carolina (1); Chemistry, Duke University, Durham, North Carolina (2)

194Young Min JuIn Situ Regeneration of Muscle Tissue through Host Cell RecruitmentYoung Min Ju; James J. Yoo; Anthony Atala; Sang Jin LeeWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine

195Jin Woo JungDevelopment of gelatin/PCL Blend Scaffold with Nasal Implant Shape for Augmentation RhinoplastyJin Woo Jung (1); Hyung-Seok Lee (1); Jung Min Hong (1); Jeong Hun Park (1); Yeong-Jin Choi (2); Jung Hee Shim (3); Woojune Hur (3); La Mee Choi (3); Tae Hyun Choi (3); Dong-Woo Cho (1)Department of Mechanical Engineering, Pohang University of Science and Technology (1); Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (2); Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine (3)

196Zeynep KarahaliloğluNanofeatured Silk Membranes for Bone-Tissue Engineering ApplicationsZeynep Karahaliloğlu (1); Batur Ercan (2); Emir B. Denkbağ (3); Thomas J. Webster (4)Nanotechnology and Nanomedicine Division, Hacettepe University (1); Chemical Engineering Department, Northeastern University (2); Chemistry Department, Biochemistry Division, Hacettepe University (3)

197Lohitash KarumbaiahChondroitin Sulfate Glycosaminoglycan Hydrogels for Neural Stem Cell TransplantationLohitash Karumbaiah; Syed Faaiz Enam; Tarun Saxena; Ravi BellamkondaGeorgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia

198Timothy KeaneRecruitment of Site-Specific Progenitors with an Esophageal Mucosal Biologic ScaffoldTimothy J. Keane (1,2); Ricardo Londono (1); Aaron Deward (1); Stephen F. Badylak (1-3)McGowan Institute for Regenerative Medicine (1); Department of Bioengineering, (2); Department of Surgery University of Pittsburgh, Pennsylvania (3)

199Allison KennamerInterstitial Cell Seeding and Conditioning of Aortic Heart Valve ScaffoldsAllison R. Kennamer (1); Leslie N. Sierad (1); Dan T. Simionescu (1)Bioengineering, Clemson University

200Eun Young KimCollagen Type I Caoted Silk and PLGA Film for Corneal Endothelial Cells Regeneration(1); Eun Young Kim (1); Sun A. Cho, (2); Chun-Ki Joo (1); Dongwon Lee (1); Gilson Khang(1); Department of BIN Fusion Technology, Department of Polymer-Nano Science & Technology and Polymer BIN Research Center, Chonbuk National University (1); Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea (2)

201Eun Young KimPorcine Collagen Powder : Contribute to Growth Behavior of Corneal Endothelial CellsEun Young Kim (1); Ji Eun Jang (1); l Jeong Eun Song (1); Soon Hee Kim (2); Byoung-Hyun Min (2); Chun-Ki Joo (3); Dongwon Lee (1); Gilson Khang (1)Department of BIN Fusion Technology, Department of Polymer-Nano Science & Technology and Polymer BIN Research Center, Chonbuk National University (1); Cell Therapy Center, Ajou University School of Medicine (2); Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea (3)

202Toyin KnightBioresponse of a Cell/alginate Hydrogel Composite in Mammalian KidneyToyin Knight (1); Richard Payne (1); Elias Rivera (1); Joydeep Basu (1); Neil Robbins (1); Darell McCoy (1); Craig Halberstadt (1,2); Manuel Jayo (1, 3), Deepak Jain (1)Tengion, Inc. (1); Organovo (2); Jayo, LLC (3)

203Chandrasekhar KothapalliMicrofluidic Device to Investigate the Effects of Microenvironment on Axonal Outgrowth and TurningJames K. Deyling; Chandrasekhar R. KothapalliDepartment of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, Ohio

204Chandrasekhar KothapalliMatrix Microenvironment Regulates Human Mesenchymal Stem Cell (HuMSC) Differentiation into Neural LineagesKurt W. Farrell; Chandrasekhar R. KothapalliDepartment of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, Ohio

205Merlin Rajesh Lal L.P.Dynamic Compression Loading Plays an Important Role in Chondrocytic Activity on Goat Chondrocytes-Agarose ConstructMerlin Rajesh Lal L.P. (1); Suraisgkumar G.K. (1); Prabha D. Nair (2)Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India (1); Department of Tissue Engineering and Regeneration Technologies, BMT Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India (2)

206Jin Ho LeePlasmid DNA-Loaded Injectable Bioactive Bulking Agent for the Treatment of Urinary IncontinenceSoo Jung Choi (1); Se Heang Oh (2); In Gul Kim (3); So Young Chun (4); Ji Youl Lee (3); Jin Ho Lee (1)Department of Advanced Materials, Hannam University (1); Department of Nanobiomedical Science (2), Dankook University; Department of Urology, Seoul Saint Mary’s Hospital, Catholic University (3); Joint Institute for Regenerative Medicine, Kyungpook National University (4)

207Sue Hyun LeeEffects of In Situ Cross-linkable Gelatin Hydrogels on Mesenchymal Stem CellsSue Hyun Lee (1); Young Wook Chun (1); Yunki Lee (2); Ki Dong Park (2); Hak-Joon Sung (1)Biomedical Engineering, Vanderbilt University (1); Molecular Science and Technology, Ajou University (2)

208Shirae LeslieControlled Released of Cells from Alginate Microbeads for Bone RegenerationShirae K. Leslie (1); David J. Cohen (1); Janina Sedlacek (2); Eric Pinsker (3); Zvi Schwartz (1) and Barbara D. Boyan (1)Biomedical Engineering, Virginia Commonwealth University (1); Division of Orthopedics, Otto-von-Guericke University (2); Biomedical Engineering, Georgia Institute of Technology (3)

209Hang LinProjection Stereolithographic Fabrication of Bone Scaffold Encapsulated with Lenti-BMP-2 transduced Human Bone Marrow Stem Cells (hBMSCs)Hang Lin (1); Ying Tang (2); Nicholas Oyster (3); Bing Wang (4); Rocky S. Tuan (5)Orthopaedic Surgery, University of Pittsburgh (1)

210Chase LinsleyMechanical Properties of and Mesenchymal Stem Cell Growth on Three-Dimensional Biomimetic Bone ScaffoldsChase Linsley (1); Roxana Fard (2); Benjamin Wu (1); Bill Tawil (1)Bioengineering, University of California, Los Angeles (1); Biotechnology & Bioinformatics, California State University Channel Islands (2)

211Srinivas MadduriNanofibrous Nerve Conduits Releasing Collagen Binding GDNF for Axonal Growth and GuidanceSandhya Ananta (2); Bruno Gander (1); Hemmi Silvio (2); Daniel Kalbermatten (3); Srinivas Madduri (1)Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland (1); Institute of Molecular Life Sciences, University of Zurich, Switzerland (2); Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital Basel, Switzerland (3)

212Srinivas MadduriInfluence of Nerve Growth Factor Availability and Guidance Features on Autonomic Axonal Regeneration for Bladder Tissue EngineeringSrinivas Madduri (1); Rita Gobet (2); Tullio Sulser (3); Daniel Eberli (3)Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland (1); University Children’s Hospital, Department of Pediatric Surgery, Zurich, Switzerland (2); University Hospital, Department of Urology, Zurich, Switzerland (3)

213Atsushi MaharaDevelopment of Small-caliber Decellularized Long-Bypass Graft Modified with Bioactive Peptides for Rapid EndotherializationAtsushi Mahara (1); Shota Somekawa (1,2); Naoki Kobayashi (1,3); Yoshiaki Hirano (3); Yoshiharu Kimura (2); Toshiya Fujisato (4), Tetsuji Yamaoka (1)Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute (1); Department of Biobased Materials Science, Kyoto Institute of Technology (2); Faculty of Chemistry, Materials and Bioengineering, Kansai University (3); Department of Biomedical Engineering, Osaka Institute of Technology (4)

214Russell MartinThe Effect of Fiber Diameter on Migration Rate of Primary Human Schwann CellsRussell Martin (1); YuJa Huang (1); Shawn Lim (2); Kellin Krick (2); Alex Mullen (1); Peter Searson (1); Ahmet Hoke (3); Hai-Quan Mao (1,2)Materials Science & Engineering, Johns Hopkins University (1); Biomedical Engineering, Johns Hopkins School of Medicine (2); Neurology and Neuroscience, Johns Hopkins School of Medicine (3)

215Michael McClureUtilizing Platelet Rich Plasma and Galectins to Create Skeletal Muscle ReplacementsMichael J. McClure (1,4); John J. Ryan (2); David G. Simpson (3); Gary L. Bowlin (4); Jeffery J. Ericksen (1)Physical Medicine and Rehabilitation, Hunter Holmes McGuire Veterans Affairs Medical Center (1); Biology, Virginia Commonwealth University (2); Anatomy and Neurobiology, Virginia Commonwealth University (3); Biomedical Engineering, Virginia Commonwealth University (4)

216Nick MernaCollagen mRNA Transcription in Fibroblasts is Regulated by Substrate Stiffness and CompositionNick J. Merna (1,2); Kelsey M. Fung (1,2); Steven C. George (1,2)Department of Biomedical Engineering, University of California, Irvine (1); Edwards Life Sciences Center for Advanced Cardiovascular Technologies, University of California, Irvine (2)

217Nguyen Minh KhanhsiRNA Delivery from In Situ Forming Degradable Hydrogels for Osteogenic Differentiation of Encapsulated hMSCsMinh K. Nguyen (1); Oju Jeon (1); Melissa D. Krebs (2); Daniel S. Schapira (1); Eben Alsberg (1,3)Biomedical Engineering, Case Wester Reserve University (1); Chemical and Biological Engineering, Colorado School of Mines (2); Orthopaedic Surgery, Case Wester Reserve University (3)


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218Neethu MohanBiosignal Reservoir Embraced Substrates for Enhanced Performance of Chondrocytes & Stem Cells In VitroNeethu Mohan (1); Dexy Joseph (1); Dhanesh Vaikkath (1); Geetha K. (1); Prabha D. Nair (1)Division of Tissue Engineering and Regeneration Technologies, Sree Chitra Tirunal Institute for Medical Sciences & Technology

219Marie MorilleNew PLGA-P188-PLGA Pharmacologically Active MicrocarriersreleasingTGF-β3 and Conveying Mesenchymal Stem Cells Induce Cartilage-like Tissue FormationMarie Morille (1,2): Marie-Claire Venier-Julienne (1); Xavier Garric (3); Danièle Noël (2); Claudia N. Montero-Menei11-LUNAM Université, UMR-S1066; INSERM, U1066, F-49933 Angers, France 2-INSERM U844, F-34091 Montpellier, France 3-Institut des biomolécules Max Mousseron, CNRS UMR 5247, Montpellier, France

220Naoko NakamuraMicroenvironment of Decellularized Bone Marrow for HSPC HomingNaoko Nakamura (1); Kwangwoo Nam (1); Tsuyoshi Kimura (1); Toshiya Fujisato (2); Hiroo Iwata (2); Akio Kishida (1) Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (1); Faculty of Engineering, Osaka Institute of Technology (2)

221Alliny Naves Biocompatibilization of Polyesters Scaffolds using LbL as Reservoirs for bFGFAlliny Ferreira Naves (1); Marvin Motay (1); Luiz Henrique Catalani (2); Gero Decher(1)Institute Charles Sadron, Centre National de la Recherche Scientifique (1); Instituto de Química, Universidade de São Paulo (2)

222Chan Ho ParkPeriodontal-Mimic Gelatin Scaffold to Guide Periodontal Ligament Regeneration and OrganizationChan Ho Park (1); Kyoung-Hwa Kim (1); Hector F. Rios (2); William V. Giannobile (2,3); Yong-Moo Lee (1); Yang-Jo Seol (1)Department of Periodontology, School of Dentistry, Seoul National University, Seoul South Korea (1); Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor (2); Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan (3)

223Janki PatelBinding Bone Morphogenetic Protein-2 to Polycaprolactone in a Clinically Applicable SettingJanki J. Patel (1); Colleen L. Flanagan (1); Dongxia Ye (2); Matthew B. Wheeler (3); Sean P. Edwards (2), Scott J. Hollister (1)Biomedical Engineering, University of Michigan, Ann Arbor (1); Oral & Maxillofacial Surgery, University of Michigan, Ann Arbor (2); Animal Sciences, University of Illinois at Urbana-Champaign (3)

224Timothy PennelTransmural Capillary Ingrowth is Essential for Mid-graft HealingTimothy Pennel (2); Deon Bezuidenhout (1); Neil Davies (1); Peter Zilla (1,2)Cardiovascular Research Unit, University of Cape Town (1); Department of Cardiothoracic Surgery, University of Cape Town (2)

225Swati Pradhan-BhattCulture of Human Salivary Gland Cells in Hyaluronic Acid (HA)-Based Hydrogels for use in Tissue Engineering ApplicationsSwati Pradhan-Bhatt (1,2,5); Xian Xu (3); Daniel A. Harrington (6); Eliza Fong (6); Xinqiao Jia (3,4); Robert Witt (1,2,5); and Mary C. Farach-Carson (1,2,6)Departments of Biological Sciences (1); The Center for Translational Cancer Research (2); Materials Science & Engineering (3); and Biomedical Engineering (4); University of Delaware, Helen F. Graham Cancer Center, Christiana Care Health Systems, Newark, Delaware (5); Department of Biochemistry and Cell Biology, Rice University, Houston, Texas (6)

226Marco QuartaArtificial Muscle Stem Cell Niche for In Vivo Volumetric Tissue EngineeringMarco Quarta (1,2); Melinda Cromie (1,2); Robert Chacon (1,2); Michael Gibbons (1,2); Antoine De Morree (1,2); Rebecca di Marco (3); Sarah Heilshorn (3); Thomas A. Rando (1,2)Department of Neurology, School of Medicine, Stanford University (1); Center for Tissue Regeneration, Restoration and Repair (CTR3), VAPAHCS (2); Department of Materials Science and Engineering, Stanford University (3)

227Raj RaoSilk Fibroin Aerogels For Mammalian Cell Culture And Tissue Engineering ApplicationsVasudha Surampudi; Rajendar R. Mallepally; Michael A. Marin; Mark A. McHugh; Raj R. RaoDepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia

228Jennifer RobinsonInjectable Foams for the Delivery of Autologous Mesenchymal Stem CellsJennifer L Robinson (1); Robert S Moglia (1); Melissa C Stuebben (1); Madison A P McEnery (1); Elizabeth Cosgriff-Hernandez (1)Department of Biomedical Engineering, Texas Agricultural & Mechanical University

229Scott RobinsonA Fibrin-rich Platelet Lysate Scaffold Promotes Invasion of Human Mesenchymal Stem CellsScott T. Robinson (1); Ian B. Copland (2); Todd C. McDevitt (3); Alexandra Peister (4); Luke P. Brewster (3,5,6)MD/PhD Program, Emory University School of Medicine (1); Hematology and Medical Oncology, Emory University School of Medicine (2); Biomedical Engineering, Georgia Institute of Technology (3); Biology, Morehouse College (4); Vascular Surgery, Emory University School of Medicine (5); Atlanta Veterans Affairs Medical Center (6)

230Daniel RoyRelease of Functional Antibiotics from a Keratin Hydrogel to Treat Cutaneous Wound InfectionDaniel Roy (1,2); David Burmeister (1); Hanyan Meng (3); Mary Ellenburg (2); Luke Burnett (2); Seth Tomblyn (2); Justin Saul (3); Robert Christy (1)Extremity Trauma Research & Regenerative Medicine, United States Army Institute of Surgical Research (1); KeraNetics, LLC (2); Miami University (3)

231Meghan SambergEffect of Platelet Incorporation within Human Plasma Hydrogels on Human Adipose-derived Stem Cell DifferentiationMeghan E. Samberg (1); Sandra C. Becerra (1); Andrew P. Cap (2); Robert J. Christy (1)Extremity Trauma and Regenerative Medicine, United States Army Institute of Surgical Research, Fort Sam Houston, Texas (1); Coagulation and Blood Research, Fort Sam Houston, Texas (2)

232Maryellen SandorComparison of Human Acellular Dermal Matrices Used in Reconstructive SurgeryMaryellen Sandor (1); Marianne Edwards (1); Eric Stec (1); Patrick G. De Deyne (1)LifeCell Corporation, Bridgewater, New Jersey (1)

233John ScottDevelopment of a Novel Tissue Engineered Muscle Repair Construct with Potential for Enhanced Motor End Plate Formation and FunctionJohn B. Scott (1,2); Benjamin T. Corona (3); Catherine L. Ward (3); Benjamin S. Harrison (1,2); Justin M. Saul (4); George J. Christ (1,2)Wake Forest Institute for Regenerative Medicine (1); Virginia Tech - Wake Forest School of Biomedical Engineering and Sciences (2); United States Army Institute for Surgical Research (3); Miami University School of Engineering and Applied Science (4)

234Jeeva SellathuraiEsophagus Reconstruction using Electrospinned PCL Scaffolds and Human Smooth Muscle CellsJeeva Sellathurai (1); Rua Al-Bader (1); Pernille Diemer (2); Prabha D. Nair (3); Niels Qvist (2); Thomas Ledet (4); Henrik D. Schrøder (1,5).Institute of Clinical Research, SDU Muscle Research Cluster, University of Southern Denmark, Odense, Denmark (1); Surgical Department A, Odense University Hospital, Odense, Denmark (2); Division of Tissue Engineering and Regeneration Technologies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India (3); Department of Biochemical Pathology, Aarhus University Hospital, Aarhus, Denmark (4) Department of Pathology, Odense University Hospital, Odense, Denmark (5)

235Lucilia SilvaEngineering Cell-adhesive Gellan Gum Spongy-like HydrogelsLucília da Silva (1); Mariana T. Cerqueira (2); Rui A. Sousa (3); Rui L. Reis (4); Vitor M. Correlo (5); Alexandra P. Marques (6)3B’s Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho (1), ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, (2)

236Keisuke TakanariMuscle-Derived Stem Cell (MDSC) Microintegrated Elastic Scaffolds for the Reconstruction of Abdominal Wall DefectsKeisuke Takanari (1,2,5); Yi Hong (1,2,6); Ryotaro Hashizume (1,2,7); Nicholas J. Amoroso (1,3); Burhan Gharaibeh (1,4); Kazuhiro Nonaka (1,2); Yuzuru Kamei (5); Johnny Huard (1,4); William R. Wagner (1,2,3)McGowan Institute for Regenerative Medicine, University of Pittsburgh (1); Department of Surgery, University of Pittsburgh (2); Department of Bioengineering, University of Pittsburgh (3); Department of Orthopaedic Surgery, University of Pittsburgh (4); Department of Plastic and Reconstructive Surgery, Nagoya University Graduate School of Medicine (5); Department of Bioengineering, University of Texas at Arlington (6); Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine (7)

237Yoshiki TaniDiagnosis for Degenerative Articular Cartilage Using Non-destructive Pulsed Laser IrradiationYoshiki Tani (1); Masato Sato (1); Munetaka Yokoyama (1); Tomonori Takagaki (1); Miyuki Kobayashi (1); Mami Kokubo (1); Goro Ebihara (1); Satoshi Ito (1); Taku Ukai (1); Miya Ishihara (2); Joji Mochida (1)(1); Department of Orthopaedic Surgical Science,Tokai University, School of Medicine (2); Department of Medical Engineering,National Defense Medical College

238Lesley-Anne TurnerA Biomaterials Approach to Treating Age-Related Macular DegenerationLesley-Anne Turner (1); Erin M. S. Baggaley (1)School of Materials, Faculty of Engineering and Physical Sciences, University of Manchester (1)

239Dhanesh VAn In Vitro Evaluation of Natural Glycosaminoglycan Polymer Based Injectable Photopolymerisable Hydrogel for Cartilage Tissue EngineeringDhanesh V.; Babitha S.; Bindu P. Nair; Prabha D. NairDivision of Tissue Engineering and Regeneration Technologies, Sree chitra Tirunal Institute for Medical Sciences and Technologies, Kerala

240Lynda Velutheril ThomasAn “Artificial Nanofibrous Niche” Supporting the Differentiation of Adipose Stem Cells to Smooth Muscle Cells under Pulsatile ConditionLynda Velutheril Thomas(1); Surya S.(1); Prabha D. Nair (1)Division of Tissue Engineering and Regeneration Technologies, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India (1)


241Lucy VojtovaGrowth Plate Cartilage Regeneration Using Allogeneic Mesenchymal Stem Cells Seeded on 3D Collagen/Chitosan Porous ScaffoldsLucy Vojtova (1); Josef Jancar (1,2); Jana Juhasova (3); Alois Necas (4); Michal Crha (4); Pavel Proks (4); Ladislav Planka (5)Central European Institute of Technology, Brno University of Technology (1); Institute of Materials Chemistry, Faculty of Chemistry, Brno University of Technology (2); Laboratory of cell regeneration and plasticity, Institute of Animal Physiology and Genetics AS CR (3); Central European Institute of Technology, University of Veterinary and Pharmaceutical Sciences Brno (4); Clinic of Pediatric Surgery, Orthopaedics and Traumatology, Faculty of Medicine, Masaryk University (5)

242Jia-Lun WangDecellularized Human Placental Vascular Scaffold Supports Repopulation of Human Primary Hepatocytes In Vitro and In VivoJia-Lun Wang; Qian Ye; Xuan Guo; Xiaowei Deng; Uri Herzberg; Mohit B. Bhatia; Wolfgang T. Hofgartner; Robert J. HaririCelgene Cellular Therapeutics

243Xintong WangA Thermo-Responsive, Self-Adhesive Injectable Heart Scaffold for Pluripotent Stem Cell-Derived Cardiomyocyte DeliveryXintong Wang (1); Lin Zhong (2); Young Wook Chun (1,2); Chee Lim (2); Charles Hong (2); Simon Maltais (3); Hak-Joon Sung (1,2)Department of Biomedical Engineering, (1); Carciovascular Medicine and (2); Cardiac Surgery, Vanderbilt University, Nashville,Tennessee (3)

244Catherine WardDevelopment of an Injectable and Settable Polyurethane Cell Delivery System for Tissue RegenerationCatherine L. Ward (1); Ruijing Guo (2); Joseph C. Wenke (1); Scott A. Guelcher (2)Extremity Trauma and Regenerative Medicine Task Area, United States Army Institute of Surgical Research, Fort Sam Houston, Texas (1); Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee (2)

245Corin WilliamsCardiac Extracellular Matrix-Fibrin Hydrogel Scaffolds with Tunable Properties for Cardiac Tissue EngineeringErica Budina (1); Corin Williams (1); Sirisha Emani (2), Sitaram Emani (2); Lauren D. Black III (1)Biomedical Engineering, Tufts University (1); Cardiac Surgery, Children’s Hospital Boston (2)

246Kelvin YeungSurface Modified 3D Porous and Nano-structured Polyetheretherketone (PEEK) For Bone Tissue EngineeringY Zhao (1); HM Wong (1); P Li (2); Z Xu (3); YW Chong (1); PK Chu (2) KWK Yeung (1)Department of Orthopaedics & Traumatology, The University of Hong Kong, Pokfulam Road, Hong Kong (1); Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (2); Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, College of Materials Science and Engineering, Hubei University, Wuhan, PR China (2)

247Munetaka YokoyamaPlatelet Activation Serum may have a Therapeutic Effect on Articular CartilageMunetaka Yokoyama(1); Masato Sato (1); Yoshiki Tani (1); Miyuki Kobayashi (1); Mami Kokubo (1); Joji Mochida (1)Department of Orthopaedic Surgical Science, Tokai University, School of Medicine (1)

248Mousa YounesiMesenchymal Stem Cells Synthesize a Tendon-Like Matrix in Woven Aligned Collagen ScaffoldsMousa Younesi (1); Anowarul Islam (1); Vipuil Kishore (1); Ozan Akkus (1, 2, 3);Department of Mechanical and Aerospace Engineering, Case Western Reserve University (1); Department of Biomedical Engineering, Case Western Reserve University (2); Department of Orthopedic Surgery, Case School of Medicine, Case Western Reserve University (3)

249Elie ZakhemA Tissue Engineered Esophageal Construct Demonstrates Physiological Functionality In VitroElie Zakhem (1,2); Khalil N. Bitar (1,2)School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest (1); Institute for Regenerative Medicine, Wake Forest Baptist Health (2)

250David ZamoraThe Effects of Magnetic Nanoparticles on Human Corneal Epithelial Cell Viability.David O. Zamora (1,2); Mauris N. DeSilva (1,3); Randolph D. Glickman (4); Heuy-Ching H. Wang (1, 2); Dallas J. Golden (1,2); Anthony J. Johnson (1,2)United States Army Institute of Surgical Research, Fort Sam Houston, Texas (1); Department of Ocular Trauma & Vision Restoration (2); Naval Medical Research Unit (3); University of Texas Health Science Center, Department of Ophthalmology, San Antonio, Texas (4)

251Michael ZimberHuman Multipotent Stem Cell Proteins Support Osteogenesis In VitroMichael Zimber (1); Emmett Pinney (1); Samantha Reiss (1); Gail K. Naughton (1,2)Histogen, Inc., San Diego, California (1); PUR Biologics, Aliso Viejo, California (2)

LATE BREAKING POSTERS252Teja GudaEnhancing Bone Regeneration in Large Bone Defects Using Structural Hydroxyapatite Compared to INFUSE®Teja Guda (1,2); Stefanie M. Shiels (2); Suyash Karajgar (1); Joseph C. Wenke (2); Joo L. Ong (1)Biomedical Engineering, University of Texas at San Antonio (1); Extremity Trauma and Regenerative Medicine, United States Army Institute of Surgical Research (2)

253Lucas HofmeisterHemodynamic Targeting of Atheroprone Vasculature for Preventative TreatmentLucas Hofmeister (1); Sue Lee (1); Wei Chen (2); Todd D. Giorgio (1); David G. Harrison (2); Hak-Joon Sung (1)Biomedical Engineering, Vanderbilt University (1); Clinical Pharmacology, Vanderbilt University (2)

254Richard LeaskSpatial Restricted Temporary Cell Permeablilization using an Inert Jet of GasRichard L. Leask (1); Paul Jonak (1); Scott Cooper (1)Department of Chemical Engineering, McGill University (1)

255Gerson AcasiguaPhysico-chemical Analysis of Electrospun Scaffolds Increased by DexamethasoneGerson A.X. Acasigua (1); Patricia Pranke (2, 3,4); Daikelly I Braghirolli (2,4); Douglas Gamba (5); Anna C.M. Fossati (1)Post-graduate Program in Dentistry (1); Hematology and Stem Cell Laboratory, Faculty of Pharmacy (2); Post Graduate Program in Physiology (3); Stem Cell Research Institute (4); Chemistry Institute, Porto Alegre, Rio Grande do Sul, Brazil (5)

256Katia Jarquín-YáñezPorosity Evaluation of Gelatin Scaffold made of Different Hyaluronic Acid DensitiesKatia Jarquin (1); Miguel Herrera (1); Beatriz Hernandez (1); Gabriela Piñon (1); Rosa Arellano (1); Daniel Santillan (1); Jesús Arenas (2); Armando Zepeda (1); Sandra Acevedo (1); Andrés Castell (1);School of Medicine UNAM, México City, Mexico (1); Institute of Physics, UNAM, México City, Mexico (2)

257Chelsea KirschnerClickable, Photodegradable Hydrogels to Dynamically Modulate Valvular Interstitial Cell PhenotypeChelsea M. Kirschner (1,3); Daniel L. Alge ( 1-3); Sarah T. Gould (1,3); Kristi S. Anseth (1-3)Department of Chemical and Biological Engineering (1); Howard Hughes Medical Institute, and the (2) Biofrontiers Institute, University of Colorado, Boulder, Colorado (3)

258Johnny LamArticular Chondrocyte and Mesenchymal Stem Cell Co-cultures in Hydrogels for Osteochondral Tissue EngineeringJohnny Lam (1); Rebecca L. Dahlin (2); Steven Lu (3); Yasuhiko Tabata (4); Antonios G. Mikos (5); F. Kurtis Kasper (6)Department of Bioengineering, Rice University (1); Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University (2)

259Ngoc Nhi LeHydrogel Array for Combinatorial Screening of Stem Cell BehaviorNgoc Nhi T. Le (1); Stefan Zorn (2); William L. Murphy (3)Materials Science Program, University of Wisconsin-Madison (1); Biomedical Engineering, University of Wisconsin-Madison (2); Orthopedics and Rehabilitation, University of Wisconsin-Madison (3)

260Sarawut ThepthongIn Vitro Aortic Reconstruction by Sandwich Model using Acellular Tissue and Collagen Cell SheetsSarawut Thepthong; Toshia FujisatoBiomedical Engineering, Osaka Institute of Technology

261Nicolas ChristoforouAssembling Functional Biosynthetic Tissues with Induced Pluripotent Stem Cell-Derived Cardiac Progenitor CellsNicolas Christoforou (1,2); Brian Liau (2); Syandan Chakraborty (2); Malathi Chellapan (2); Nenad Bursac (2); Kam W. Leong (2)Department of Biomedical Engineering, Khalifa University, Abu Dhabi (1); Department of Biomedical Engineering, Duke University, Durham (2)

262Sarah Sundelacruz3D Tissue Repair Model for Studying Bioelectric Signaling During Bone Wound HealingSarah Sundelacruz (1); Chunmei Li (1); Young Jun Choi (1); Michael Levin (2); David L. Kaplan (1)Department of Biomedical Engineering, Tufts University, Medford, Massachusetts (1); Department of Biology and Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts (2)

263Marcella VaicikHydrogel Stiffness and Degradation Regulate Adipose Expansion In VitroMarcella K. Vaicik (1,2); Sonja Sokic (1); Georgia Papavasiliou (1); Eric M. Brey (1,2);Biomedical Engineering, Illinois Institute of Technology (1); Research Service, Edward Hines Junior Veterans Affairs Hospital, Hines, Illinois (2)

264Mathew VarkeySuperficial Dermal Fibroblasts Enhance Basement Membrane and Epidermal Barrier Formation in Tissue Engineered SkinMathew Varkey (1); Jie Ding (1); Edward Tredget (1,2)Division of Plastic and Reconstructive Surgery (1); University of Alberta; Division of Critical Care Medicine (2); University of Alberta

265Gilson KhangInfluence of MSCs on the Response of ECs to Laminar Flow and Shear StressHyeongseok Kim (1); Minsung Hong (1); Hansu Jo (1); Randall F. Ankeny (2); Casey J. Holliday-Ankeny (2); Gilson Khang (1); Robert M. Nerem (1, 2)Department of BIN Fusion Technology, Department of PolymerNano Science & Technology and Polymer BIN Research Center, Chonbuk National University Jeonju, Chonbuk, Korea (1); Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology (2)

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POSTER SESSION II – TUESDAY, NOVEMBER 12, 2013 2:30 – 4:00 PM POSTER SESSION I – MONDAY, NOVEMBER 11, 2013 4:30 – 6:00 PM

266Miguel Herrera-EnríquezActivation of Osteoblasts Chondroblasts and Fibroblasts Derived From Human Stromal Bone Marrow Cells, Seeded on Cadaveric Demineralized Human Cancellous Bone Scaffold (Biosponge-Novoinjertos).Miguel Herrera(1); Beatriz Hernández (1); Judith Alvarez (1); Gabriela Piñon (1); Katia Jarquin (1); Sandra Acevedo (1); Pablo Castell (2); Sergio Guevara (2); Teofilo Bandera (2); Raul Flores (3); Francisco Limon (3); Enrique Obermeier( 3); Agustin Carrillo (3); Department of Cell and Tissue Biology, Medicine School, Universidad Nacional Autónoma de México (1); General Hospital, ISSSTE, and Sanatorio de Padre Jesús, Iguala, Gro. México (2); Tissue Bank Novoinjertos, México City, México (3)

267Gilson KhangGrowth Behavior of Corneal Endothelial Cells on Silk SubstrataSeung Chang Oh (1); Cheon Jung Lee (1); Min Ju Na (1) Jin Young Park (1); Eun Young Kim (1); Jeong Eun Song (1); Choun-Ki Joo (2); Dongwon Lee (1); Gilson Khang (1) Department of BIN Fusion Technology, Department of PolymerNano Science & Technology and Polymer BIN Research Center, Chonbuk Natl Univ, Jeonju, Chonbuk, Korea (1); Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University (2)

268Gilson KhangBiological Characterization through a Variety of Formulation of High and Low Acyl Gellan GumHye Yun Kim (1); So Jin Lee (1); Young Lae Kim (1); Eun Young Kim (1); Jeong Eun Song (1); Rui. L. Reis (2); Gilson Khang (1)Department of BIN Fusion Technology, Department of PolymerNano Science & Technology and Polymer BIN Research Center, Chonbuk National University, Jeonju, Chonbuk, Korea (1) 3B’s Research Group-Biomaterials, Biodegradables and Biomimetics, University Minho (2)

269Gilson KhangCharacterization of Collagen and Hydroxyapatite Coated Silk for Application in Biomedical MaterialsJeong Eun Song (1); Seung Chang Oh (1); Jeawon Yang (1); Hye Yoon Kim (1); Eun Young Kim (1); Chan Hum Park (2); Gilson Khang (1)Department of BIN Fusion Technology, Department of PolymerNano Science & Technology and Polymer BIN Research Center, Chonbuk National University, Jeonju, Chonbuk, Korea (1); Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Collage of Medicine (2)

270Gilson KhangThe Effect of Silk Films on the Growth Behavior of Retinal Pigment Epithelial CellsSo Jin Lee (1); Jaewon Yang (1); Jung Hwan Lee (1); Eun Young Kim (1); Jeong Eun Song (1); Choun-Ki Joo (2); Dongwon Lee (1); Gilson Khang (1)Department of BIN Fusion Technology, Department of PolymerNano Science & Technology and Polymer BIN Research Center, Chonbuk National University, Jeonju, Chonbuk, Korea (1); Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University (2)

271Sandy LinOrganic Solvent-Free Polymeric Scaffolds for Tissue Engineering ApplicationsSandy T.C. Lin (1); David Musson (2); Debes Bhattacharyya (1); Jillian Cornish (2)Centre for Advanced Composite Materials, Department of Mechanical Engineering, The University of Auckland (1); Department of Medicine, The University of Auckland (2)

272Xin LinImplantable Extracellular Matrix Bioscaffold Augmented with Mesenchymal Stromal Cells for Cardiac RepairXin Lin; Tye Petrie; W. Douglas Boyd; Claus S. SondergaardDepartment of Surgery, University of California, Davis, Medical Center, Sacramento, California

273Ashwin NairAutologous Stem Cell-derived Bone Tissue Engineering in PeritoneaJinhui Shen (1); Ashwin M. Nair (1); Chengcheng Zhang (2); Ramesh Saxena (3); Liping Tang (1)Bioengineering, University of Texas Southwestern Medical Center and University of Texas at Arlington (1); Physiology and Developmental Biology, University of Texas Southwestern Medical Center (2); Internal Medicine, University of Texas Southwestern Medical (3)

274Thomas NauIn Vivo Results of a Regenerated Anterior Cruciate Ligament Using a Novel Silk-Fiber Based Scaffold DeviceAndreas H. Teuschl; Sylvia Nürnberger; Martin Mayer; Pavol Szomolanyi; Siegfried Trattnig; Heinz Redl; Thomas Nau University of Applied Sciences Technikum Wien, Vienna, Austria - City of Vienna Competence Team Tissue Engineering Bioreactors; The Austrian Cluster for Tissue Regeneration, Vienna, Austria; Ludwig Boltzmann Institute for Experimental and Clinical

275Patricia PrankeNovel Chemically Modified Bacterial Cellulose Nanocomposite as Potential Biomaterial for Stem Cell Therapy ApplicationsPatricia Pranke; Gerson Arisoly Xavier Acasigua; Gabriel Molina de Olyveira; Ligia Maria Manzine Costa; Daikelly Iglesias Braghirolli; Anna Christina Medeiros Fossati; Antonio Carlos Guastaldib; Pierre Basmaji Hematology and Stem Cell Laboratory, Faculty of Pharmacy; Post Graduate Program in Physiology; Stem Cell Research Institute; Post-graduate Program in Dentistry, Porto Alegre, Rio Grande do Sul; Department of Physical Chemistry, Araraquara

276Patricia PrankeAssociation of Nanotechnology with Stem Cells to be used in Third Degree Burn Animal ModelsPatricia Pranke (1,2,4); Daniela Steffens (1,2); Dilmar Leonardi (1); Paula R. da L. Soster (3); Michelle Lersch (1); Annelise Rosa (1); Thayane Crestani (1); Cristiane Scher (1); Michele G. de Morais (5); Jorge A.V. Costa (5)Hematology and Stem Cell Laboratory, Faculty of Pharmacy (1); Post Graduate Program in Physiology (2); Department of Morphological Science (3); Federal University of Rio Grande do Sul; Stem Cell Research Institute (SCRI) (4) ; Porto Alegre, RS; Laboratory (5)

277Patricia PrankeMensenchymal Stem Cells and their use in the Reconstruction of Thyroid Cartilage using Nanofibers as ScaffoldsPatricia Pranke; Geraldo P. Jotz; Paula Rigon da Luz Soster; Carlos Afonso Beck; Marcelo Muccilo; Daniela Steffens; Daikelly I. Braghirolli; Rui Fernando Felix Lopes; Bernardo MastellaHematology and Stem Cells Laboratory, Faculty of Pharmacy; Federal University of Grande do Sul; Post Graduate Program in Physiology; Federal University of Grande do Sul; Morphological Science Department; Federal University of Grande do Sul

278Patricia PrankePhysico-chemical Analysis of Electrospun Scaffolds Increased by DexamethasonePatricia Pranke (1,2,3); Gerson A.X. Acasigua (4); Daikelly I. Braghirolli (1,3); Douglas Gamba (5); Anna C.M. Fossati (4)Hematology and Stem Cell Laboratory, Faculty of Pharmacy (1); Post Graduate Program in Physiology (2); Stem Cell Research Institute (3); Post-graduate Program in Dentistry (4); Chemistry Institute, Porto Alegre, Rio Grande do Sul, Brazil (5)

279Patricia PrankeNeural Differentiation of Mesenchymal Stem Cells Cultivated on Aligned Nanofiber ScaffoldsPatricia Pranke (1,2); Thayane Crestani (1); Kerlin Quintiliano (1); Virginia E. Helfer (1); Davi S. Santos (1); Eduardo A. Balbueno (1); Estela M. Cruvinel (3); Antonio C. Cassola (3); Diogo A. Pilger (1); Geraldo Jotz (4)Hematology and Stem Cell Laboratory, Faculty of Pharmacy (1) ;Stem Cell Research Institute (SCRI); Porto Alegre, RS (2); Biosciences Institute, Federal University of São Paulo (3); Department of Morphological Sciences; Federal University of Rio Grande (4)

280Kazuya SawadaFabrication of the Keratin Protein Scaffold for Chondrocyte CultivationKazuya Sawada (1,2); Hiroki Goto (3); Toshiya Fujisato (3)Department of Integrated Life, Osaka Seikei College (1) Department of Biomedical Engineering, Osaka Institute of Technology (2) Major in Biomedical Engineering, Osaka Institute of Technology (3)

281Nadia VázquezBiocompatibility of a Chitosan (CTS) - Polylactic Acid (PLA) Based Scaffold for the Development of a Biological Dermal SubstituteNadia Vázquez (1,2); Andres Espadín (3); Keiko Shirai (3); Lenin Tamay (2); Lilia Solis (2); Antonio Medina (4); Cristina Velasquillo (2).National Autonomus University of Mexico (1) Biotechnology Laboratory, National Institute of Rehabilitation (2) Biopolímers Laboratory, Metropolitan Autonomus University (3) General Surgery Department, National Institute of Pediatrics (4)

282Daniel YoungstromMechanical Strain Induces Equine Mesenchymal Cell Differentiation Toward Tendon and Increases Matrix StrengthDaniel W. Youngstrom (1); Jennifer G. Barrett (1); Shannon L. Smith (2); Jonathan A. Kluge (2); David L. Kaplan (2)Marion duPont Scott Equine Medical Center, Virginia Tech (1); Tissue Engineering Resource Center, Tufts University (2)

ACELLULAR THERAPIES

100Amit AuroraEfficacy of Extracellular Matrix Scaffold for the Functional Restoration of Musculotendinous Junction InjuryAmit Aurora (1); Benjamin Corona (1); Janet Roe (1); Thomas Walters (1)Extremity Trauma Research Division, United States Army Institute of Surgical Research (1)

101Stephen BadylakBiologic Scaffolds Composed of Extracellular Matrix Promote a Constructive Macrophage PhenotypeBrian M. Sicari, (1,2); Jenna Dziki (1); Christopher L. Dearth (1,2); Stephen F. Badylak (1,3,4)McGowan Institute for Regenerative Medicine (1); Department of Pathology (2); Department of Surgery University of Pittsburgh, Pittsburgh, Pennsylvania (3); Department of Bioengineering University of Pittsburgh, Pittsburgh, Pennsylvania (4)

102Alexander BaumeDevelopment of an Antibacterial-Eluting Bi-Phasic Scaffold for Wound HealingAlexander S. Baume (1); Philip C. Boughton (1); Nicholas V. Coleman (2); Susan V. McLennan (3); Andrew J. Ruys (1)Biomedical Engineering, School of Aerospace, Mechanical & Mechatronic Engineering, University of Sydney, Australia (1); School of Molecular & Microbial Biosciences, University of Sydney, Australia (2); Sydney Medical School, University of Sydney, Australia (3)

103Charito BuensucesoEffects of Acellular Dermal Matrix Extracts on the Migration and Proliferation of Endothelial CellsCharito Buensuceso (1); Nalinai Scott (1); Sean Collins (1); Patrick G. De Deyne (1)LifeCell Corporation (1)

104Alonzo CookOptimization of Decellularization Processes for Renal StructuresJeffery J. Nielson (1); Brent D. Young (2); Brendan G. Ashton (3); Cory A. Fronk (2); Grant W Holden (2); Jonathan J. Wisco (4); Jeffery R. Barrow (4); Beverly L. Roeder (5); Alonzo D. Cook (2)Biochemistry, Brigham Young University (1); Chemical Engineering, Brigham Young University (2); Biophysics, Brigham Young University (3); Physiology and Developmental Biology, Brigham Young University (4); Biology, Brigham Young University (5)

105Gabriella DahlgrenIs In Vivo Recellularization of Acellular Dermal Matrices Associated with Variables in the ECM?Gabriella M. Dahlgren (1); Pearl M. Assan (1); Maryellen Sandor (1); Patrick G. De Deyne (1)LifeCell Corporation (1)

106Christopher DearthThe Effect of Terminal Sterilization on Material Properties and In Vivo Remodeling of a Porcine Dermal Biologic ScaffoldChristopher Dearth (1,2); Christopher Carruthers (1,3); Janet Reing (1); Christian Ranallo (1); Elizabeth Kollar (1); Peter Crapo (1,2); Scott Johnson (1); Stephen Badylak (1-3)McGowan Institute for Regenerative Medicine, University of Pittsburgh (1); Department of Surgery, University of Pittsburgh (2); Department of Bioengineering, University of Pittsburgh, Pennsylvania (3)

107Timothy GaneyExploiting Truss Geometry as an Acellular Adjuvant to Spine FusionTimothy Ganey (1); Lisa Ferrara (2); Peggy Lalor (3); Jessee Hunt (4)Orthopaedic Surgery, Atlanta Medical Center (1); OrthoKinetic, LLC (2); Histion, LLC (3); 4WEB, Inc. (4)

108Jose GarciaEnhanced Therapeutic Effects of PEG Hydrogels Functionalized with VEGF and a Collagen-mimetic Adhesive Peptide for Bone DefectsJose R. Garcia (1); Amy Y. Cheng (2); Andres J. Garcia (3)Woodruff School of Mechanical Engineering, Georiga Institute of Technology (1); Institute for Bioengineering and Biosciences, Georgia Institute of Technology (2)

109David Giraldo GomezCharacterization of a New Scaffold Obtain by Enzymatic Treatment for Engineering CartilageDavid M. Giraldo Gomez (1); David Garciadiego Cazares (2); Cristina Piña Barba (3)Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (1); Unidad de Ingeniería de Tejidos Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación (2); Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (3)

110Li Ting HuangDevelopment of In Vitro Assays to Measure Acellular Matrix Induced Inflammatory ResponsesLi Ting Huang (1); Hua Wan (1); Hui Xu (1)Research & Development, LifeCell Corporation (1)

111Jason InzanaDesign & Characterization of 3D Printed Collagen-Calcium Phosphate Composites for Bone Defect RepairJason A. Inzana (1,2); Diana Olvera (1,2); Seth Fuller (4); Olivia A. Graeve (4,5); Edward M. Schwarz (1,2,3); Stephen L. Kates (2,3); Hani A. Awad (1,2,3)Biomedical Engineering, University of Rochester (1); Center for Musculoskeletal Research, University of Rochester Medical Center (2); Orthopaedics, University of Rochester Medical Center (3); Kazuo Inamori School of Engineering, Alfred University (4); Mechanical and Aerospace Engineering, University of California, San Diego (5)

112Tae Ho KimTreatment of Hearing Loss Using Ion-complexed Drug-loaded HydrogelTae Ho Kim (1); Jae-Jun Song (2); Se Heang Oh (3); Jin Ho Lee (1)Department of Advanced Materials, Hannam University (1); Deptartment of Otorhinolaryngology, Dongguk University Ilsan Hospital (2); Department of Nanobiomedical Science, Dankook University (3)

113Joydip KunduDecellularized Retinal Matrix as Substrate for Delivery of Human Retinal Progenitor CellsJoydip Kundu (1); Andrew Michaelson (1); Kristen Talbot (1); Petr Baranov (2), Michael J. Young( 2) and Rebecca L. Carrier (1)Chemical Engineering, Northeastern University, Boston, Massachusetts (1); Schepens Eye Research Institute, an Affiliate of Harvard Medical School, Boston, Massachusetts (2)

114Fanwei MengEffect of Extracellular Matrix Bioscaffolds on Microglia PhenotypeFanwei Meng (1,2,3); Christopher Medberry (1,2); Christopher L. Dearth (1,2,3); Stephen F. Badylak(1,2,3)McGowan Institute for Regenerative Medicine, University of Pittsburgh (1); Department of Surgery, University of Pittsburgh (2); Department of Bioengineering, University of Pittsburgh (3)

115Amanda MillerMatrACELL® Pulmonary Artery Allograft for Cardiovascular Repairs Compared to Porcine Small Intestinal Submucosa with Respect to its Extent of Decellularization and Extracellular ComponentsAmanda Houck Miller (1); Alyce Linthurst Jones (1)Research and Development, LifeNet Health (1)

116Nima MomtahanNovel Thrombogenicity Analysis of Decellularized Cardiac OrgansNima Momtahan (1); Sivaprasad Sukavaneshvar (2); Beverly L Roeder (3); Jeffery R Barrow (4); William G Pitt (1); Alonzo D Cook (1)Chemical Engineering, Brigham Young University (1); Thrombodyne, Incorporated (2); Biology, Brigham Young University (3); Physiology and Developmental Biology, Brigham Young University (4)

117Michael RaxworthyPerformance In Vivo of EktoTherix, a Synthetic Acellular Scaffold for Wound RegenerationLorenzo Pio Serino (1); Peter D. Iddon (1); Michael J. Raxworthy (1)Neotherix Limited (1)

118Mark TattertonTissue Engineering a Small Diameter Cell Seeded Vascular GraftDr. Mark Tatterton (1); Dr. Stacy-Paul Wilshaw (2); Professor Eileen Ingham (2); Professor Shervanthi Homer-Vanniasinkam (1);Leeds Vascular Institute, Leeds General Infirmary, Leeds, United Kingdom (1); Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom (2)

119Maxime TondreauCharacterisation of an Entirely Biological Tissue-Engineered Fibroblast-derived Scaffold for Vascular ApplicationsMaxime Tondreau (1,3); Véronique Laterreur (2,3); Karine Vallières (3) Jean-Michel Bourget (1,3); Dan Lacroix (3); Jean Ruel (2,3); Lucie Germain (1,3); François A. Auger (1,3)Department of Surgery, Laval University (1); Department of Mechanical Engineering, Laval University (2); Laval University LOEX Center - Regenerative Medicine Axis of the FRQS Quebec City CHU Research Center (3)

120Mujib UllahGenomic and Proteomic Analysis of Extracellular Fat Matrix Reveals a Uniform Structural and Functional Network for Cellular InteractionsMujib Ullah; Stefan Stich; Yvonne Wloka; Sarah Sommerkamp; Michael Sittinger and Jochen RingeTissue Engineering Laboratory and Berlin-Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Charitéplatz,Berlin, Germany

121Lisa WhiteHydrogels Derived from Demineralized and Decellularized Bone - Novel Materials for Bone RegenerationLisa J. White (1); Stephen F. Badylak (2); Kevin M. Shakesheff (1)School of Pharmacy, University of Nottingham (1); McGowan Institute for Regenerative Medicine, University of Pittsburgh (2)

CELL ENGINEERING/SYNTHETIC BIOLOGY

122Hyunhee AhnFabrication of Small Diameter Vascular Grafts by Combining Cell Sheet Engineering and Electrospinning TechnologyHyunhee Ahn (1); Young Min Ju (2); Hironobu Takahashi (2);Teruo Okano (1); James J. Yoo (1); Anthony Atala (1); Sang Jin Lee (1) Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine (1); Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University (2)

3332

POSTER SESSION II – TUESDAY, NOVEMBER 12, 2013 2:30 – 4:00 PM POSTER SESSION II – TUESDAY, NOVEMBER 12, 2013 2:30 – 4:00 PM

123Tae Hyun ChoiRegeneration of Peripheral Nerves by Transplanted Sphere of Human Mesenchymal Stem Cells Derived from Embryonic Stem CellsEun Ju Lee (1); Lianji Xu (2); Gi-Hwan Kim (1); Soo Kyoung Kang (1); Sae-Won Lee (1); Sung-Hye Park (3); Sukwha Kim (2); Tae Hyun Choi (2); Hyo-Soo Kim (1,4)National Research Laboratory for Stem Cell Niche and IRICT, Seoul National University Hospital, Republic of Korea (1); Department of Plastic and Reconstructive Surgery, Institute of Dermatologic Science, Seoul National University College of Medicine, Republic of Korea (2); Department of Pathology, Seoul National University College of Medicine, Republic of Korea (3); Molecular Medicine & Biopharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea (4)

124Fiona FreemanSimulating the Biochemical and Mechanical cues of Endochondral Ossification to Develop an Effective Bone Tissue Regeneration StrategyFiona E. Freeman (1,2); Matthew G. Haugh (1,2); Laoise M. McNamara (1,2)Centre for Biomechanics Research (BMEC), Biomedical Engineering, NUI Galway, Ireland (1); National Centre for Biomedical Engineering Sciences, NUI Galway, Ireland (2)

125Masanobu HorieGrowth in Single Aggregates of Human Induced Pluripotent Stem CellsMasanobu Horie; Emilda Teresa Gomez; Eiji Nagamori; Masahiro Kino-okaDepartment of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan

126Takahiro IwamiyaThe Functional Evaluation of ES Cell-derived Cardiac Cell Sheet with Different Types of FibroblastsTakahiro Iwamiya; Katsuhisa Matsuura; Tatsuya Shimizu; Noriko Yasuda; Teruo OkanoInstitute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University

127Jaehyun KimDownregulation of Metabolic Activity Increases Cell Survival under Hypoxic ConditionsJaehyun Kim; Karl-Erik Andersson; Sang Jin Lee;John D. Jackson; James Yoo; Anthony AtalaWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina

128Xia LiuSelf-Renewal and Differentiation Capacity of Urine-Derived Stem Cells after Urine Preservation for 24 HoursLiu Xia; Ren Lang; Guihua Liu; Yingai Shi; Shantaram Bharadwaj; Anthony Atala; Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina

129Dawit SeifuEngineering a Multi-wall Vascular Construct by Directly Processing Cells and Collagen Gels in Co-culture in Rotating BioreactorDawit G Seifu (1); Sébastien Meghezi (1); Larry Unsworth (2); Kibret Mequanint (3); Diego Mantovani (1)Laboratory for Biomaterials and Bioengineering, Laval University, Québec City, Canada (1); Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Canada (2); Department of Chemical and Biochemical Engineering, Western University, London, Canada (3)

130Stefan StichCharacterization of Sngle Cell Derived Cultures of Periosteal Progenitor Cells to Ensure the Quality for Clinical ApplicationStefan Stich (1); Alexander Loch (2); Michael Sittinger (1); Jochen Ringe (1)Tissue Engineering Laboratory & Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Germany (1); Department of Otorhinolaryngology, Charité - Universitätsmedizin Berlin, Germany (2)

131Qian WanFunctional Urothelial Differentiation of Urine-derived Stem Cells for Potential use in Urethral Tissue RepairQian Wan; Guihua Liu; Shantaram Bharadwaj; Anthony Atala; Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina

132Lijun ZhangImmunoregulatory Property of Long-term Cultured Human Mesenchymal Stem Cell SheetsLijun Zhang (1,2); Lei Chen( 2); Qi Xing (1); Mitchell Tahtinen (1); Feng Zhao (1)BioMedical Engineering, Michigan Technological University, Houghton, Michigan (1); Department of Burns, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (2)

COMPUTATIONAL MODELING

133Pinar HuriModeling In Vitro Adipose-Derived Stem Cell Myogenesis in Response to Biophysical CuesPinar Y. Huri (1); Douglas J. DiGirolamo (2); Alexander A. Spector (1); Warren L. Grayson (1)Biomedical Engineering, Johns Hopkins University (1); Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland (2)

134Jeong-Hoon OhFabrication of Biomimetic Shaped Ceramic Ossicles and Evaluation of their Vibration Performance using Finite Element MethodJeong-Hoon Oh (1); Jung-Seob Lee1 (2); Dong-Woo Cho (2)Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, Korea (1); Department of Mechanical Engineering, Pohang University of Science and Technology, Korea (2)

IMAGING (CELL TRANSPLANTATION, TISSUE FUNCTION, REGENERATION)

135Alyssa AppelVisualizing Hydrogels in Soft Tissue with X-rays without Contrast AgentsAlyssa A. Appel (1,2); Jeffery C. Larson (1,2); Alfred B. Garson III (3); Huifeng Guan (3); Bin Jiang (1,2); Zhong Zhong (4); Mark A. Anastasio (3); Emmanuel C. Opara (5); Eric M. Brey (1,2)Biomedical Engineering, Illinois Institute of Technology (1); Research Services, Edward Hines Jr. VA Hospital (2); Biomedical Engineering, Washington University in St. Louis (3); National Synchrotron Light Source, Brookhaven National Laboratory (4); Institute for Regenerative Medicine Center for Biomolecular Imaging Center for Diabetes Research, Wake Forest (5)

136Alyssa AppelMonitoring Tissue Development within Bioreactors without Exogenous ContrastAlyssa A. Appel (1,2); Jeffery C. Larson (1,2); Alfred B. Garson III (3); Huifeng Guan (3); Zhong Zhong (4); Bao-Ngoc Nguyen(5); John Fisher (5); Mark A. Anastasio (3); Eric M. Brey (1,2)Biomedical Engineering, Illinois Institute of Technology (1); Research Services, Edward Hines Jr. VA Hospital (2); Biomedical Engineering, Washington University in St. Louis (3); National Synchrotron Light Source, Brookhaven National Laboratory (4); Department of Bioengineering, University of Maryland (5)

137Ian CoplandMicrofluidic Modeling of MSC Homing/Engraftment Recapitulates In Vivo Engraftment Defects Associated with CryopreservationRaghavan Chinnadurai (1); Yumiko Sakurai (2,3); Wilbur Lam (2,3); Jacques Galipeau (1,2); Ian Copland (1)Department of Hematology and Oncology, Winship Cancer Institute, (1); Department of Pediatrics, Emory University (2); Wallace H. Coulter Department of Biomedical Engineering, and Georgia Institute of Technology (3)

138Joshua FarberPre-Operative Evaluation of Patients Undergoing Knee Articular Cartilage Defect Repair: MRI 3D Thickness Maps derived from a Validated, Automated Segmentation PlatformJoshua M. Farber, MD; Eric Brandser, MD; Saara Totterman, MD, PhD; Jose Tamez-Pena, PhD; Bruce Holladay, MD; John Larkin, MD; Forest Heis, MD; Philip SmithClinical Applications, Qmetrics Technologies; Division of Radiology, Radiology Associates of Northern Kentucky; Clinical Applications, Qmetrics Technologies; Imaging Science and Statistics, Tec de Monterrey; Orthopedic Surgery, Commonwealth Orthopaedic Centers; Orthopedic Surgery, Commonwealth Orthopaedic Centers; Orthopedic Surgery, Commonwealth Orthopaedic Centers

139Zohreh IzadifarLower Dose X-ray Imaging for Visualization of Scaffolds Implanted in CartilageZohreh Izadifar (1); L. Dean Chapman (1,2,3); X.B. Daniel Chen (1,4)Division of Biomedical Engineering, University of Saskatchewan (1); Department of Anatomy and Cell Biology, University of Saskatchewan (2); Biomedical Imaging and Therapy (BMIT) Beamline, Canadian Light Source (CLS) (3); Department of Mechanical Engineering, University of Saskatchewan (4)

140Shruti KanakiaAA Novel MRI Contrast Agent to Assess Tissue Growth of Renal TransplantShruti Kanakia; Jimmy Toussaint; Sayan Mullick Chowdhary; Tanuf Tembulkar; Stephen Lee; Kenneth Shroyer; William Moore; Balaji SitharamanDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York; Department of Radiology, Stony Brook University, Stony Brook, New York; Department of Pathology, Stony Brook University, Stony Brook, New York

141Hyung Keun KimBone Forming Peptide1 (BFP1) Enhances ALP Expression and Osteogenic Differentiation via Smad and Erk Signal Protein Stimulation during OsteogenesisHyung Keun Kim (1,2); Ji Hyun Kim (2); Dae Sung Park( 2); Kyung Soon Park (2); Jong Keun Seon(2); Eun Kyoo Song (2); Myung Ho Jeong (1); Taek Rim Yoon (1,2)Heart Research Center of Chonnam National University Hospital, Gwangju, Korea (1); Joint Center of Chonnam National University Hwasun Hospital, Jeonnam, Korea (2)

142Mike ModoUse of MRI to Non-Invasively Guide ECM-Gel Treatment of Stroke Lesions in a Rat ModelAndre R. Massensini (1,3,5); Christopher J. Medberry (1,2); Wen Ling (1,3); Stephen F Badylak (1,2,4); Michel Modo (1,2,3)University of Pittsburgh, McGowan Institute for Regenerative Medicine (1); Department of Bioengineering (2); Department of Radiology (3); Department of Surgery, Pittsburgh, Pennsylvania (4); Universidade Federal de Minas Gerais, Department of Physiology and Biophysics, Belo Horizonte, Brazil (5)

143Aaron MohsNear Infrared Labeling and Detection of Enteric Nerve Cells: Tracking of Differentiating Neural Progenitor Cells and Tissue InnervationAaron M. Mohs (1,2); Robert R. Gilmont (1); Christopher Booth (1); Lysette A. Mutkus (1); Frank C. Marini (1); Khalil N. Bitar (1,2)Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina (1); Wake Forest - Virginia Tech School of Biomedical Engineering and Sciences, Winston Salem, North Carolina (2)

144Guoguang NiuFluorescent Imaging of Cells in Tissue Engineering Blood Vessels: the Impact of Cross-linking on Autofluorescence of the ScaffoldGuoguang Niu (1); Etai Sapoznik (1,3); Peng Lu (2); Tracy Criswell (1); Aaron M. Mohs (1,3); Ge Wang (3); Sang-Jin Lee (1); Yong Xu (2); Shay Soker (1,3)Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center,Medical Center Boulevard, Winston-Salem, North Carolina (1); Bradley Department of Electrical and Computer Engineering (2); Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Virginia Technical Institute, Blacksburg, Virginia (3)

145Karl NobertThe Regulation of Regenerative Medicine in the United StatesKarl M. NobertSquire Sanders (United States) LLP, Washington, District of Columbia

146Ryan PorterRefinement of a Rat Model for Studying Progenitor Cell Contribution to Osteochondral Defect RepairRyan M. Porter (1); Alfredo M. Scheu (1); Fangjun Liu (1); James W. Wells (1,2); Elisabeth Ferreira (1); Christopher H. Evans (1)Orthopaedic Surgery, Beth Israel Deaconess Medical Center / Harvard Medical School (1); Epithelial Cancer Division, University of Queensland Diamantina Institute (2)

147Jason RashkowTowards Nanobiomaterials for Stem Cell Therapies in Regeneration Medicine: The Effects of Two Dimensional Carbon Nanoparticles on the Viability and Differentiation of Adipose Derived Stem CellsJason T Rashkow (1); Yahfi Talukdar (1); Gaurav Lalwani (1); Balaji Sitharaman (1)Biomedical Engineering, Stony Brook University (1)

148Etai SapoznikFiber Based Imaging on Electrospun ScaffoldEtai Sapoznik (1,2); Guoguang Niu (1); Peng Lu (3); Tracy L. Criswell(1); Yong Xu (2,3); Shay Soker (1,2)Wake Forest Institute for Regenerative Medicine, Wake Forest University (1); Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences (2); Department of Electrical and Computer Engineering, Virginia Technical Institute (3)

149Maya Schnabel-LubovskyNano-Scale Cell-Matrix Interactions through Amorphous Hydrogel Polymeric NetworksMaya Schnabel-Lubovsky (1,2); Dror Seliktar (1,3); Yeshayahu Talmon (2,3).Departments of Biomedical Engineering,Technion-Israel Institute of Technology (1); Chemical Engineering, Technion-Israel Institute of Technology (2); The Russell Berrie Nanotechnology Institute (RBNI), Technion-Israel Institute of Technology (3)

150John WalkerPerfusion CT for Assessment of en bloc Implant Vascular SuccessJohn A. Walker (1,2); Marcello Pilia (2); Thomas J. Walters (2); Jennifer McDaniel (2); Joseph C. Wenke (1,2); Christopher R. Rathbone (2)Department of Radiology, University of Texas Health Science Center at San Antonio (1); Extremity Trauma & Regenerative Medicine, United States Army Institute of Surgical Research (2)

151Sean WhiteLongitudinal Quantification of Vascular Density and Function in Implantable Porcine Acellular Dermal MatrixSean M. White (1); Chelsea Pittman (1); Tamim Diab (2); Patrick G. De Deyne (2); Steven C. George (1); Bernard Choi (1)Biomedical Engineering, University of California, Irvine (1); LifeCell Corporation (2)

IMMUNOMODULATION

152Gustavo GarletDAMPS/CD14/MYD88 Axis In Host Response To Biomaterial Grafting: Understanding and Interfering With The Inflammatory Immune Response to Enhance Healing and Regeneration Processes OutcomeElcia MV Silveira (1); Ana C Araujo-Pires (1); Carlos E Repeke (1); Ana Paula Campanelli (1); Joao S Silva (1); Ana Paula Favaro Trombone (2); Gustavo Pompermaier Garlet(1)FOB/USP, Sao Paulo University, Bauru, SP, Brasil (1); Universidade Sagrado Coração Bauru, SP, Brasil (2)

153Devon HeadenMicrofluidic Gelation of Synthetic Cell-Laden Microgels: Controlling Particle Size with Flow RateDevon M. Headen (1); Guillaume Aubry (2); Hang Lu (3); Andrés J. García (4)Woodruff School of Mechanical Engineering, Georgia Institute of Technology (1); Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology (2); School of Chemical and Biomolecular Engineering, Georgia Institute of Technology (3)

154Mohammad HossainRecombinant Flagellin Enhances NK Cell Immunity against CMV Infection: a Clinical ImplicationMohammad S. Hossain (1); Edmund K. Waller (1)Department of Hematology and Medical Oncology, Division of Bone Marrow Transplantation, Winship Cancer Institute, Emory University (1)

155Sunyoung JooMyogenic differentiated Allogeneic Mesenchymal Stem Cells are Capable of Modulating the Immune Response by Regulatory T CellsSunyoung Joo (1,2); Hyun Ju Lim (1); John D. Jacksonv (1); Anthony Atala (1); James J. Yoo (1,2)Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine (1); Joint Institute for Regenerative Medicine, Kyungpook National University Hospital (2)

156Hyung Keun KimSalidylideneamino-2-thiophenol Enhances ALP and Calcium Activity via MAPK Signaling Pathway Stimulation during OsteogenesisHyung Keun Kim (1,2); Ji Hyun Kim (2); Dae Sung Park (2); Kyung Soon Park (2); Jong Keun Seon (2); Eun Kyoo Song (2); Myung Ho Jeong (1); Taek Rim Yoon (1,2)Heart Research Center of Chonnam National University Hospital, Gwangju, Korea (1); Joint Center of Chonnam National University Hwasun Hospital, Jeonnam, Korea (2)

157Christina RossEffect of Pulsed Electromagnetic Field on Inflammatory Pathway Markers in RAW 264.7 Murine MacrophagesChristina L. Ross (1,2); Benjamin S. Harrison (2)Akamai University, Department of Energy Medicine, Hilo, Hawaii (1); Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina (2)

158Kara SpillerVascularization of Tissue Engineering Scaffolds through Modulation of Macrophage BehaviorKara L. Spiller (1); Rachel Anfang (1); Krista J. Spiller (2); Johnathan Ng (1); Gordana Vunjak-Novakovic (1)Biomedical Engineering, Columbia University (1); Pathology, Columbia University (2)

159Zhengsheng ZhangImmunomodulatory Properties of Urine-Derived Stem CellsZhengsheng Zhang (1); Rongpei Wu (1,2); Melisa Soland (1); Guihua Liu (1); Anthony Atala (1); Graca Almeida-Porada (1) and Yuanyuan Zhang (1)Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina (1); The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China (2)

160Joshua ZimmermannModulation of Mesenchymal Stem Cell Microenvironments to Enhance Immunomodulatory Paracrine SecretionJoshua A. Zimmermann (1); Todd C. McDevitt (1,2)The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University (1); The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology (2)

MANUFACTURING TECHNOLOGIES AND PLATFORMS

161Taby AhsanHypoxia Effects on Pluripotent Stem Cell Differentiation is Modulated by the Physical MicroenvironmentRussell P. Wolfe (1); Taby Ahsan (1)Biomedical Engineering, Tulane University (1)

162David DeanResin Component Optimization for Green Strength of Photocrosslinked Resorbable Scaffolds Prepared by Continuous Digital Light Processing (cDLP) Additive ManufacturingDavid Dean (1); Eric Mott (1); Xinyi Luo (2); Martha O. Wang (3); Charlotte E. Vorwald (3); Ali Siblani (4); John P. Fisher (3)Plastic Surgery, The Ohio State University (1); Neurological Surgery, Case Western Reserve University (2); Fischell Department of Bioengineering, University of Maryland (3); EnvisionTEC, Inc. (4)

163Timothy GaneySurface Characterization of Etched PEEK ImplantsTimothy Ganey (1); Lisa Detter-Hoskin (2); Frank E. Livingston (3)Department of Orthopaedic Surgery, Atlanta Medical Center (1); Materials Analysis, Georgia Institute of Technology Research Institute (2); Aerospace Corporation (3)

164Timothy GaneyAdvanced Laser Technology for Developing Biomimetic Implants in a Sheep Model for Intervertebral Body FusionFrank E. Livingston (1); Patrick Colahan (2); Ted Broom (2); Timothy Ganey (3)Aerospace Corporation (1); Large Animal Surgery, College of Veterinary Medicine, University of Florida (2); Department of Orthopaedic Surgery, Atlanta Medical Center (3)

3534


165Anastasia GeorgiouChemical Osteoinduction with Simvastatin and Generation of 3D Mineralised Cellular Constructs In a Perfusion BioreactorAnastasia Georgiou (1); Eleftherios Tsiridis (2); Manolis Heliotis (3); Athanasios Mantalaris (1)Biological Systems Engineering Laboratory, Department of Chemical Engineering, Imperial College London (1); Faculty of Medicine, Imperial College London Medical School (2); Northwick Park Hospital, Maxillofacial Unit, London, United Kingdom (3)

166Jonathan GerstenhaberDelta-Style Robot for Electrospinning from Rapid Prototyped PartsJonathan A Gerstenhaber (1); Patrick Thompson (2); Yah-el Har-el (1); Peter I. Lelkes (1)Department of Bioengineering, Temple University (1); School of Biomedical Engineering Science and Health Systems, Drexel University (2)

167Stephen GoldmanShear Stress Modulates Expression of Collagen mRNAs in Bone Marrow Derived Mesenchymal Stem CellsStephen M. Goldman (1,2); Gilda A. Barabino (1,3)Interdisciplinary Bioengineering Graduate Program, Georgia Institute of Technology (1); G.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology (2); Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology (3)

168Revital GoldshmidMicrogel Suspension Culture System for hMSCs BioprocessingRevital Goldshmid and Dror SeliktarFaculty of Biotechnology, Technion - Israel Institute of Technology, Haifa, Israel

169Wada MasanoriThe Development of Small Scale Bioreactor System for Human Induced Pluripotent Stem Cell Culture Wada Masanori (1); Matsuura Katsuhisa (2); Ishikawa Yoichi (1); Shimizu Tatsuya (2); Okano Teruo (2)R and D Section, Able Corporation, Tokyo, Japan (1); Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan (2)

170Brian NankervisShear Stress Conditions in the Quantum Cell Expansion SystemBrian Nankervis (1); Kristina Fuerst (1); Khoa Vu (1)Terumo BCT (1)

171Se Woong ParkCombination of Superhydrophilc Surface and Chemically Bindable Surface for Enhacing Bone DifferentiationSe Woong Park (1); Bo Ra Lee (2); Sung Gap Im (2); Il Keun Kwon( 1)School of Dentistry, Kyung Hee University (1); Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (2)

172Sua ParkPreparation of NaOH-treated Surface on Three-dimensional (3D) Polymeric Scaffold Fabricated by Rapid PrototypingSua Park (1); Junhee Lee (1); Wandoo Kim (1)Nano-Mechanical Systems Research Division, Korea Institute of Machinery & Materials (1)

173Joshua PriceCyclic Hydrostatic Pressure Stimulates Enhanced Bone Formation in hMSC-seeded Hydrogels and Organotypic Skeletal Cultures.Joshua Price (1); James R. Henstock (1); Yvonne Reinwald (1); Alicia J. El Haj (1)Institute for Science and Technology in Medicine, Keele University, United Kingdom

174Vanessa RagagliaGMP Manufacture of a Clinical-Grade, Off-the-Shelf, Adult Bone Marrow-Derived Stromal Cell ProductVanessa Ragaglia; Priya R. BaraniakResearch Operation, Garnet BioTherapeutics, Inc.

175Rodrigo RezendeDual Scale Scaffolds via Fusion Deposition Modeling and Electrospinning for Tissue Engineering ApplicationsM.A. Sabino (1,2); R. Rezende (1); M. Loaiza (2,3); J. Salazar (2), Z. Fermin (1,2); F.D. Pereira (1); P. Inforcatti (1); V. Mironov (1); J.L. Da Silva (1)Division of 3D Technologies, Center for Information Technology Renato Archer, Campinas, São Paulo, Brazil (1); Department of Chemistry, Grupo B5IDA, Universidad Simón Bolívar, Caracas, Venezuela (2); Department of Chemistry, Universidad Nacional Exp. Francisco de Miranda. Pto. Fijo, Falcón, Venezuela (3)

176Rodrigo RezendeScalable Biofabrication of Chondrospheres from Human Adipose Stem Cells Isolated by Mechanical Dissociation: a Comparison with Human Cartilage-derived Progenitors CellsKarina R. Silva (1); Vladimir Mironov (2); Rodrigo A. Rezende (2); Jorge V.L. da Silva (2); Mellanie P. Stuart (1); João V. Belizário (1,4); Paulo E. Leite (1); Radovan Borojevic (3); José Mauro Granjeiro (1); Leandra Baptista (1,4)Division of Bioengineering, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, RJ, Brazil (1); Division of 3D Technologies, Center for Information Technology Renato Archer, Campinas, SP, Brazil (2); Excellion laboratory, Petrópolis, RJ, Brazil (3); Federal University of Rio de Janeiro/Xerém, Duque de Caxias, RJ, Brazil (4)

177Nian ShenDevelopment of a Bioreactor System for 2D and 3D ElastogenesisNian Shen (1,2); Svenja Hinderer (1,3); Jan Hansmann (2); Katja Schenke-Layland (1,2)Department of Cell and Tissue Engineering, Fraunhofer IGB, Stuttgart, Germany (1); University Women’s Hospital Tübingen and Inter-University Centre for Medical Technology Stuttgart-Tübingen (IZST), Eberhard Karls University, Tübingen, Germany (2); Institut für Grenzflächenverfahrenstechnik und Plasmatechnologie (IGVP), University of Stuttgart, Germany (3)

178Mousa YounesiFabrication of 3D-Complex Solid Forms by Electrochemical Compaction of Collagen Rich SolutionsMousa Younesi (1); Vipuil Kishore (1); Anowarul Islam (1); Ozan Akkus (1, 2, 3)Department of Mechanical and Aerospace Engineering, Case Western Reserve University (1); Department of Biomedical Engineering, Case Western Reserve University (2); Department of Orthopedic Surgery, Case School of Medicine, Case Western Reserve University (3)

179Long ZhaoControlled Micro-droplet Deposition and Application for Cell PrintingLong Zhao (1); Chang K. Yan (2); Feng Lin (3); Wei Sun (4)Biomanufacturing Engineering Research Institute, Department of Mechanical Engineering, Tsinghua University (1); Department of Mechanical Engineering, The College of New Jersey (2); Department of Mechanical Engineering, Drexel University (3)

PARACRINE/TROPHIC DELIVERY

180Ashley AllenPre-Cultured vs. Syringe-Injected Hydrogels for In Vivo Stem Cell DeliveryAshley B. Allen (1); Ian B. Copland (2); Hazel Y. Stevens (3); Robert E. Guldberg (1,3)Bioengineering, Georgia Institute of Technology (1); School of Medicine, Emory University (2); Mechanical Engineering, Georgia Institute of Technology (3);

181Archana BoopathyHydrogel Stiffness Dependent Notch1 Activation Regulates Cardiogenic Gene Expression in Rat Cardiac Progenitor CellsArchana V. Boopathy (1); Pao Lin Che (1); Vince F. Fiore (1); Milton E. Brown (1); Yoshie Narui (2); Khalid Salaita (2); Thomas H. Barker (1); Michael E. Davis (1)Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, Georgia (1); Department of Chemistry, Emory University, Atlanta, Georgia (2)

182Wei ChenSkeletal Myogenic Differentiation of Urine-Derived Stem Cells and Angiogenesis Using Microbeads Loaded with Growth Factors for Potential Treatment of Stress Urinary IncontinenceWei Chen; Guihua Liu; Rajesh A. Pareta; Rongpei Wu; Yingai Shi; Xiaobo Zhou; Anthony Atala; Emmanuel C. Opara and Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina

183Brandon HannaRole of HIF-1 in Transducing the Effects of Ischemic Preconditioning of Mesenchymal Stem Cells for Bone RepairBrandon Hanna (1); Suchit Sahai (1); Matt Skiles (1); James BlanchetteBiomedical Engineering, University of South Carolina (1)

184Jennifer LeiBiomolecule Delivery from MSC Spheroid Surfaces for Modulation of Local Tissue EnvironmentJennifer Lei (1); Tobias Miller (2); Johnna S. Temenoff (2,3)George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology (1); Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University (2); Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology (3)

185Aaron MakiCulturing Porcine Adipose-Derived Stem Cells with Platelet-Rich PlasmaAaron J. Maki (1); Rathnaweera A.C. Rabel (2); Ekta Khetan (3) Anna C.M. Ercolin (2); Kelly S. Roballo (2); Jamey J. Cooper (4); Matthew B. Wheeler (1,2)Bioengineering, University of Illinois (1); Animal Sciences, University of Illinois (2); Birla Institute of Technology, Hyderabad, India (3); Molecular and Cellular Biology, University of Illinois (4)

186Ina SarelA Peripheral Blood-derived Cellular Population can be Differentiated into Neural like Progenitor CellsIna Sarel (1); Valentin Fulga (1)Research and Development, Hemostemix (1)

187Claire SegarHarnessing Macrophage-Derived Paracrine Signaling to Modulate Hematopoietic Stem CellsClaire Segar (1); Molly Ogle (1); Edward Botchwey (1)Biomedical Engineering, Georgia Institute of Technology and Emory University (1)

188Aleksander SkardalDelivery of Amniotic Fluid-Derived Stem Cells in a Heparin-Functionalized Hyaluronic Acid Hydrogel Gel Accelerates Skin RegenerationAleksander Skardal (1); Sean Murphy (1); David Mack (2); Shay Soker (1)Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine (1); Department of Rehabilitation Medicine, University of Washington (2)

189Ni SuNano-fibrous Scaffolds Potentiate the Anti-inflammatory and Angiogenic Paracrine Function of Adipose-derived Stem CellsNi Su (1); Yi Zhong (1); Kai Wang (1); Ying Luo (1,2); Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China (1); National Engineering Laboratory, Biomedical Engineering, Georgia Institute of Technology (1); Biomedical engineering, Emory University (2)

190Jenna WilsonAlginate Microencapsulation Modulates the Phenotype and Secretion of Embryonic Stem Cell AggregatesJenna L. Wilson (1); Mohamad Ali T. Najia (1); Rabbia Saeed (1); Todd C. McDevitt (1,2)The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia (1); The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia (2)

POLYTRAUMA MODELS OF REPAIR/REGENERATION

191Mariana CerqueiraGellan Gum-Hyaluronic Acid Spongy-like Hydrogels and Adipose Tissue-Derived Lineages Synergise Towards Skin RegenerationM. T. Cerqueira; L. P. da Silva; T. C. Santos; R. P. Pirraco; V. M. Correlo; A. P. Marques; R. L. Reis3B’s Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal

192Tracy CriswellAge and Gender Dependent Differences in Skeletal Muscle Regeneration after Compression Injury in RatsTracy Criswell (1); Yu Zhou (1); Daniel Lovell (1); Maigen Bethea (1); Shay Soker (1)Wake Forest Institute for Regenerative Medicine, Wake Forest University (1)

193Yang LiuA Self-assembling Peptide Reduces Glial Scarring, Attenuates Post-traumatic Inflammation and Promotes Neurological Recovery following Spinal Cord InjuryYang Liu (1); Hui Ye (1); Kajana Satkunendrarajah (1); Gordon S. Yao (1); Yves Bayon (2); Michael G. Fehlings (1,3,4)Department of Genetics and Development, Toronto Western Research Institute and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada (1); Covidien - Sofradim Production, Trevoux, France (2); Department of Surgery, University of Toronto, Ontario, Canada (3); Institute of Medical Sciences, University of Toronto, Ontario, Canada (4)

194Vasudevan MahalingamAllogenic vs Autologous Derived Cell Sources for use in Engineered Bone-Ligament-Bone for Sheep ACL RepairVasudevan Mahalingam (1); Michael J. Smietana (2); Tyler J. Olsen (3); Edward M. Wojtys (4); Deneen M. Wellik (5,6); Ellen M. Arruda (3,7); Lisa M. Larkin (1,2)Molecular & Integrative Physiology, University of Michigan (1); Biomedical Engineering, University of Michigan (2); Mechanical Engineering, University of Michigan (3); Orthopaedic Surgery, University of Michigan (4); Internal Medicine, University of Michigan (5); Cell & Developmental Biology, University of Michigan (6); Macromolecular Science & Engineering, University of Michigan (7)

195Michael SmietanaUtilization of 3-D Tissue Engineered Constructs to Improve Tendon-Bone Healing Following Rotator Cuff RepairMichael J. Smietana (1); Ellen M. Arruda (1,2,3); Asheesh Bedi (4); Lisa M. Larkin (1,5)Biomedical Engineering, University of Michigan (1); Mechanical Engineering, University of Michigan (2); Macromolecular Science and Engineering , University of Michigan (3); Orthopedic Surgery, University of Michigan (4); Molecular & Integrative Physiology, University of Michigan (5)

196Joshua TamIn Vivo Reconstitution of Epidermal and Dermal Skin Structures from Microscopic Skin Tissue ColumnsJoshua Tam (1); Ying Wang (1); William A. Farinelli(1); R. Rox Anderson (1)Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (1)

197Zhan WangMethods to Improve Expansion and Engraftment of Myogenic Progenitor Cells for Muscle RegenerationZhan Wang (1); Dan Cheung (2); Yu Zhou (1); Changjie Han (1); Tracy Criswell (1); Shay Soker (1,3)Wake Forest Institute for Regenerative Medicine (1), Oregon State University, School of Chemical, Biological, and Environmental Engineering (2)

PRECLINICAL ANIMAL MODELS

198Jonathan CheethamNerve Specific Extracellular Matrix Hydrogel for Laryngeal Nerve RepairJonathan Cheetham (1); Travis Prest (2); Matthew Martin (1); Samuel LoPresti (2); Manuel Martine (1); Bryan N. Brown (2)Cornell University, Ithaca, New York (1); University of Pittsburgh, Pittsburgh, Pennsylvania (2)

199Tracy CriswellCell Therapy for the Functional Improvement of Injured Skeletal Muscle in Older RatsTracy Criswell (1); Yu Zhou (1); Daniel Lovell (1); Maigen Bethea (1); Shay Soker (1)Wake Forest Institute for Regenerative Medicine, Wake Forest University (1)

200Celeste FinnertyCharacterization of Adipose Derived Stem Cells (ASCs) Following Burn InjuryAnesh Prasai (1); Amina El Ayadi (2, 5); David N. Herndon (2,5); Celeste C. Finnerty (2,3,4,5)Cell Biology Graduate Program, University of Texas Medical Branch (1); Department of Surgery, University of Texas Medical Branch (2); Institute for Translational Sciences, University of Texas Medical Branch (3); Sealy Center for Molecular Medicine, University of Texas Medical Branch (4); Shriners Hospital for Children (5)

201Joseph FrankPulse Focused Ultrasound (pFUS) Exposures in Muscle Causes Biphasic Molecular Changes Resulting in Enhanced Homing of Stem Cells: Implications for Cell TherapyPamela A. Tebebi (1); Scott R. Burks (2); Ben A. Nguyen (2); Saejeong J. Kim (2); Priyanka Venketesh (2); Joseph A. Frank (2)Biomedical Engineering, The Catholic University of America, Washington, District of Columbia (1); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Maryland (2)

202Amalia Gallegos-CardenasRobust Generation of Neural Stem Cells from Pig Induced Pluripotent Stem Cells for Translational Neural Regenerative MedicineAmalia Gallegos-Cardenas(1-3); Kai Wang (2); Erin T. Jordan (1,2); Rachel West (1,2); Franklin D. West (1,2); Jeong-Yeh Yang (1,2) and Steven L. Stice (1,2)Department of Animal and Dairy Science, the University of Georgia (1); Regenerative Bioscience Center, the University of Georgia, Athens, Georgia (2); Department of Animal Production, National Agrarian University La Molina, Lima, Peru (3)

203Rebecca HowieBisphosphonate Release from Bone Following Cadmium AdministrationR. Nicole Howie (1); Tara Brown (2); Loan Tran (2); J. Nathan Raley (2); Maryka Bhattacharyya (3); James Borke (4); Mohammed Elsalanty (1)Oral Biology, Georgia Regents University (1); College of Dental Medicine, Georgia Regents University (2) Orthopedics, Georgia Regents University (3); College of Dental Medicine, Western University of Health Sciences (4)

204Dietmar HutmacherA Novel Spatiotemporal Delivery System of rhBMP-2 for the Regeneration of Critical Sized Bone Defects in an Ovine Large Animal ModelJan Henkel (1); Arne Berner (1,2); Siamak Saifzadeh (1); Ian C. Dickinson (4); Mia Woodruff (1), Robert E. Guldberg (3); Michael A. Schuetz (1,4); Dietmar W. Hutmacher (1,3)Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (1); Department of Trauma Surgery, Regensburg University Medical Center, Germany (2); George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology (3); Department of Orthopaedic Surgery, Princess Alexandra Hospital and the Wesley Medical Centre, Brisbane (4)

205Vivek RautTethered Epidermal Growth Factor Delivery for the Repair of Large Segmental Bone DefectsVivek P. Raut (1); Jaime J. Rivera (2); Viviane Luangphakdy (1); Phil Zaveri (1); Luis M. Alvarez (2); Linda A. Stockdale (2); Cynthia A. Boehm (1); Alan Wells (3); Linda G. Griffith (2); George F. Muschler (1)Biomedical Engineering, Cleveland Clinic (1); Biological and Mechanical Engineering, Massachusetts Institute of Technology (2); Department of Pathology, University of Pittsburgh (3)

206Kiyoko TakemiyaTherapeutic use of Encapsulated Genetically Engineered Mesenchymal Stem Cells for Vascular RegenerationKiyoko Takemiya (1); Jane S. Titterington (1); Giji Joseph (1); Daiana Weiss (1); Alicia N. Lyle (1); Christa Caesar (1); Susan A. Safely (2); Collin Weber (2); Ian B. Copland (3); Jacques Galipeau (3,4); W. Robert Taylor (1,5,6)Division of Cardiology, Emory University School of Medicine (1); Department of Surgery, Emory University School of Medicine (2); Department of Hematology and Medical Oncology, Emory University School of Medicine (3); Department of Pediatrics and Medicine, Hematology and Medical Oncology, Emory University School of Medicine (4); Cardiology Division, Atlanta Veterans Affairs Medical Center (5); Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology (6)

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REPROGRAMMING CELLS FOR REGENERATION

227James DixonSwitching Alginate/Collagen Hydrogels Tailored for Human Pluripotent Stem Cell Self-renewal and DifferentiationJames E. Dixon (1); Catherine Rogers (1); Disheet A. Shah (1); Stephen Hall (2); Chris Denning (3); Kevin M. Shakesheff (1)Wolfson Centre for Stem Cells, Tissue Engineering, and Modelling (STEM), Centre of Biomolecular Sciences, School of Pharmacy (1); School of Clinical Science (3), Medical Engineering Unit (2), University of Nottingham, Nottingham, United Kingdom

228Jochen RingeDifferentiation, Dedifferentiation and Transdifferentiation Potential and Mechanisms of Human MSCJochen Ringe (1); Mujib Ullah (1); Michael Sittinger (1)Tissue Engineering Laboratory & Berlin-Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany (1)

229Amogh SivarapatnaModulation of Arterio-Venous Identity in Endothelial Cells Derived from Human Induced Pluripotent Stem Cells using Shear StressAmogh Sivarapatna (1); Mahboobe Ghaedi (2); Julio Mendez (2); Wei Wu (3); Yibing Qyang (4); Laura E Niklason (1, 2)Department of Biomedical Engineering, Yale University(1); Department of Anesthesiology, Yale University (2); Department of Surgery, Yale University (3); Department of Medicine, Yale University (4)

230Xuefeng YangHuman Urine-derived Stem Cells Originate from Parietal Stem CellsXuefang Yang (1); Rongpei Wu (1,2); Guihua Liu (1); Yuxin Fan (3); Jan Rohozinski (1,4); Anthony Atala (1) and Yuanyuan Zhang (1)Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina (1); The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China (2); John Welsh Cardiovascular Diagnostic Laboratory, Department of Pediatrics, Baylor College of Medicine, Houston, Texas (3); Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas (4)

231Shuo YinChondrogenic Transdifferentiation of Human Dermal Fibroblasts Stimulated with CartilageDerived Morphogenetic Protein1Shuo Yin (1,2); Lian Cen (2) Wei Liu (1,2); Yilin Cao (1,2)Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, Shanghai Jiao TongUniversity School of Medicine, Shanghai, China (1); National Tissue EngineeringCenter of China, Shanghai, China (2)

TUMOR ENVIRONMENTS & CANCER BIOLOGY (LESSONS LEARNED)

232Luis AlonzoA 3D In Vitro Tumor Microenvironment with Perfused CapillariesLuis Alonzo (1,2); Monica Moya (1,2); Marian Waterman (3,4); Chris Hughes (1,2,5); Steven George (1,2,6)Biomedical Engineering, University of California Irvine (1); Edwards Lifesciences Center for Advanced Cardiovascular Technology (2); Microbiology and Molecular Genetics, University of California Irvine (3); Cancer Research Institute Research Centers and Institutes, University of California, Irvine (4); Molecular Biology and Biochemistry, University of California, Irvine (5); Chemical Engineering and Material Science, University of California, Irvine (6)

233Boris HolzapfelHumanized Animal Models of Prostate Cancer Bone Metastasis - a New Method to Investigate Species-specific Mechanisms of Cancer Cell OsteotropismBoris Michael Holzapfel (1); Laure Thibaudeau (1); Pamela Russell (2); Dietmar Werner Hutmacher (1);Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (1); Australian Prostate Cancer Research Center, Translational Research Institute, Brisbane, Australia (2)

234Esmaiel JabbariInert Patterned Matrix for Engineering Cancer Stem Cell NicheSamaneh K. Sarvestani, Esmaiel JabbariUniversity of South Carolina, Columbia, South Carolina

235Tsuyoshi KimuraPreparation of Decellularized Melanoma Tissue using High Hydrostatic Pressure TechnologyMitsuki Ueki (1); Tsuyoshi Kimura (1); Naoko Nakamura (1); Kwangwoo Nam (1); Toshiya Fujisato (2); Akio Kishida (1)Tokyo Medical and Dental University (1;) Osaka Institute Technology (2)

236Shantanu PradhanA Tissue-engineered Model of Breast Cancer Formed Using PEG-fibrinogen Hydrogel MicrospheresShantanu Pradhan (1); Jacob M. Clary (1); Elizabeth A. Lipke (1)Chemical Engineering, Auburn University (1)

237Nathan RohnerTumors Change the Elastic and Viscoelastic Properties of Draining Lymph Node TissuesNathan A. Rohner (1); Jacob McClain (1); Sara L. Tuell (1); Susan N. Thomas (1)Mechanical Engineering, Georgia Institute of Technology (1)

238Vincent SiuThe Effects of Various Fruit Extracts, Collagen, and Fibronectin on the Proliferation and Migration of the Rhabdomyosarcoma-derived (RD) Cell LineVincent Siu (1); Stephanie DeSanti (1); Victor Mikhaltsevich (1); Danny Tran (1); Melissa McCoy (1); Bill Tawil (1)Department of Biotechnology and Bioinformatics, California State University, Channel Islands (1)

239Laure ThibaudeauInvestigating the Role of β1 Integrin in Breast Cancer Bone Metastasis Using In Vitro and In Vivo Tissue Engineered Bone ModelsLaure C. Thibaudeau (1); Anna V. Taubenberger (2); Boris M. Holzapfel (1); Dietmar W. Hutmacher (1)Institute of Health and Biomedical Innovation, Queensland University of Technology (1); BIOTEChnologisches Zentrum, Technische Universität Dresden (2)

VASCULARIZATION

240Eren Raif AyataDevelopment of Capillary-like Structures in Psoriatic Skin SubstitutesRaif Eren Ayata (1,2); Michèle Auger (3); Roxane Pouliot (1,2)Faculté de Pharmacie, Université Laval, Québec, Canada (1); Centre LOEX de l’Université Laval, Québec, Canada (2); Département de Chimie, Regroupement québécois de recherche sur la fonction, la structure et l’ingénierie des protéines (PROTEO), Centre de recherche sur les matériaux avancés (CERMA), Québec, Canada (3)

241Srishti BhutaniVascular Differentiation of Cardiac Progenitor Cells in VEGF-immobilized PEG Hydrogel ScaffoldSrishti Bhutani (1); Apoorva S. Salimath (2); Archana V. Boopathy (1); Andres J. Garcia (2); Michael E. Davis (1,3)Department of Biomedical Engineering, Georgia Institute of Technology and Emory University (1); School of Mechanical Engineering, Georgia Institute of Technology (2); Division of Cardiology, Emory University (3)

242Rachel CampbellIn Vivo Microanastomosis of Microvessel Containing Tissue-Engineered Constructs: The Final FrontierRachel Campbell (1); Karina A. Hernandez (1); Tatiana Boyko (1) , Jeremiah Joyce (1), Adam M. Jacoby (1); Jason A. Spector (1)Plastic Surgery, Weill Cornell Medical College (1)

243Stephen CronkAdipose-derived Stem Cells from Healthy and Diabetic Mice have Differential Effects on the Retinal MicrovasculatureStephen M. Cronk (1); Thomas A. Mendel (2); Ethan L. Nyberg (1); Anthony R. Sheets (3); Anthony C. Bruce (1); Ira M. Herman (3); Paul A. Yates (2); Shayn M. Peirce (1)Biomedical Engineering, University of Virginia (1); Ophthalmology, University of Virginia (2); Molecular Physiology and Pharmacology, Tufts University (3)

244Caitlin CzajkaScaffold-free, Self-assembled, Vascularized Tissue ConstructsCaitlin A. Czajka (1); Christopher J. Drake (1)Regenerative Medicine & Cell Biology, Medical University of South Carolina (1)

245Ruby DewiChemotaxis of Human Induced Pluripotent Stem Cell-Derived Endothelial CellsNgan F. Huang (1,2,3); Ruby E. Dewi (4); Janet Okogbaa (1); Jerry C. Lee (1); Abdul J. Rufaihah (1); Sarah C. Heilshorn (4); John P. Cooke (1,2).Division of Cardiovascular Medicine, Stanford University (1); Stanford Cardiovascular Institute, Stanford University (2); Center for Tissue Regeneration, Repair, and Restoration, Veterans Administration Palo Alto Health Care System (3); Department of Materials Science and Engineering, Stanford University (4)

246Traci GoodchildPreclinical Evaluation of Vasomotion at 12 Months in a Bioresorbable Vascular Scaffold Implanted in Porcine Coronary ArteriesTraci T. Goodchild (2); James J. Benham (1); Steve H. Hsu (1); Deepal K. Panchal (2); Shashi F. Bhushan (3); David J. Lefer (3); Laura E.L. Perkins (1); Alexander J. Sheehy (1); Byron J. Lambert (1); Daniel L. Cox (1); Richard J. Rapoza (1)Abbott Vascular, Santa Clara, California (1); Saint Joseph’s Translational Research Institute, Atlanta, Georgia (2); 3 Emory University. Atlanta, Georgia (3)

247Bernadine IdowuEngineering Stem Cell Niches- a Model for Vascularization and MineralizationBernadine D. Idowu; Eman Alfayez; Lucy Di SilvioBiomaterials, Tissue Engineering & Imaging Group, Kings College London, Dental Institute, London, United Kingdom

248Eric NguyenHydrogel Array for Screening Endothelial Cell Behavior in Three-dimensional Synthetic EnvironmentsEric Nguyen (1); Matthew Zanotelli (1); Cody Bindl (1); William Murphy (1,2)Biomedical Engineering, University of Wisconsin-Madison (1); Orthopedics and Rehabilitation, University of Wisconsin-Madison (2)

207Laure ThibaudeauHumanized Xenograft Model of Breast Cancer Metastasis to BoneLaure C. Thibaudeau (1); Boris M. Holzapfel (1); Brett Hollier (1); Carl A. Power (2); Anna V. Taubenberger (3); Dietmar W. Hutmacher (1)Institute of Health and Biomedical Innovation, Queensland University of Technology (1); Biological Resource Imaging Laboratory, University of New South Wales (2); BIOTEChnologisches Zentrum, Technische Universität Dresden(3)

208Thomas WaltersChronic Activity Improves Skeletal Muscle Tissue Functional Recovery after Volumetric Muscle LossThomas J. Walters (1); Koyal Garg (1); Benjamin T. Corona (1)Extremity Trauma and Regenerative Medicine; United States Army Institute of Surgical Research (1)

REJUVENATING TISSUE/ORGAN FUNCTION

209Sunitha ChandranImproved Fracture Healing in Rat Osteoporotic Model Using Mesencgymal Stem Cell-Seeded Strontium Incorporated HydroxapatiteSunitha Chandran (1); Suresh S Babu (2); Hari Krishnan V.S. (3); Harikrishna Varma (4); Annie John (5)Transmission Electron Microscope, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (1); Bioceramics Laboratory, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (2); Division of Laboratory Animal Science, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (3); Bioceramics Laboratory, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (4); Transmission Electron Microscope, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (5)

210Ethan DaleyPhenotypic Differences in White-tailed Deer Antlerogenic Progenitor Cells and Marrow-Derived MSCEthan L.H. Daley (1,2); Andrea I. Alford (2); Steven A. Goldstein (1,2)Biomedical Engineering, University of Michigan (1); Orthopaedic Surgery, University of Michigan (2)

211Roger De FilippoProtective Effect of Human Amniotic Fluid Stem Cells in Acute Tubular NecrosisLaura Perin (1,2,3,4,6,7); Sargis Sedrakyan (1,2,3,4,6,7); Stefano Da Sacco (1,2,3,4,6,7); Gianni Carraro (2,3,6,7); Liron Shiri (1,2,3,4,6,7); Kevin Lemley (2,3,5,6,7); and Roger De Filippo (1,2,3,4,6,7)GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics (1); Saban Research Institute (2) ; Children’s Hospital Los Angeles (3); Division of Urology (4); Division of Nephrology (5); Keck School of Medicine (6); University of Southern California (7)

212Roger De FilippoAmniotic Fluid Renal Progenitors and renal Extracellular Matrix: A New Approach for Kidney RegenerationIlenia Zanusso (1,2,3,4,6,7); Stefano Da Sacco (1,2,3,4,6,7); Astgik Petrosyan (1,2,3,4,6,7); Maria Teresa Conconi (1,2,3,4,6,7); Kevin Lemley (2,3,5,6,7) ; Laura Perin (1,2,3,4,6,7); Roger De Filippo (1,2,3,4,6,7)GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics (1); Saban Research Institute (2); Children’s Hospital Los Angeles (3), Division of Urology (4); Division of Nephrology (5); Keck School of Medicine (6); University of Southern California (7)

213Francis FernandezResurfacing Articular Cartilage in a Caprine Model: Adipose Derived Stem Cells & Engineered CeramicsFrancis B. Fernandez (1); Suresh S. Babu (2); Sachin J. Shenoy (3); Harikrishna Varma (4); Annie John(5)Transmission Electron Microscope, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (1); Bioceramics Laboratory, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (2); Division of Invivo Models & Testing, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (3); Bioceramics Laboratory, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (4); Transmission Electron Microscope, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology (5)

214Anthony FreiIn Vivo Effects of Macroporous Scaffolds on Non-Human Primate Mesenchymal Stem CellsAnthony W. Frei (1,2); Melissa A. Willman (1); Dong Mei Han (1); Alexander Rabassa (1); Ethan Yang (1,4); Jaime A. Giraldo (1,2); Dora M. Berman (1); Norma S. Kenyon (1,2,3); Cherie L. Stabler (1,2,3):Diabetes Research Institute, University of Miami (1); Department of Biomedical Engineering, University of Miami (2); Department of Surgery, University of Miami (3); Department of Biochemistry and Molecular Biology, University of Miami (4)

215Samir HasanStem Cell Concentration in Pediatric Adipose TissueSheshashree Seshadri (1); Shaye Walston (1); Loretta Reyes (1); Ifeanyi Mbadugha (1); Kevin Hopkins (2); Samir Hasan (3); Joan Nichols (3)Pediatrics, Driscoll Children’s Hospital (1); Plastic Surgery, Driscoll Children’s Hospital (2); Tissue Engineering and Organ Regeneration University of Texas Medical Branch (3)

216Jinah JangApplication of Decellularized ECM as a Bio Ink of 3D Cell Printing for Site Appropriate Tissue FormationJinah Jang (1); Tae-Ha Song (2); Min-Joo Kim (1); Sung Won Kim (3); Dong-Woo Cho (2)Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (1); Mechanical Engineering, Pohang University of Science and Technology (2); Otolaryngology-Head and Neck Surgery, The Catholic University of Korea (3)

217Han-Tsung LiaoThe Effect of Bone-mimetic Environment on Osteogenic Potential of Bone Barrow and Adipose Derived Mesenchymal Stem CellHan-Tsung, Liao (1,2); Chien-Tzung Chen (1); Jyh-Ping, Chen (2)Division of Trauma Plastic Surgery, Department of Plastic and Reconstructive Surgery, Craniofacial Research Center, Chang Gung Memorial Hospital, Taiwan (1); Department of Chemical and Materials Engineering, Chang Gung University (2)

218Susan ManiExpansion of Mesenchymal Stem Cells at Physiological Oxygen Levels Delays SenescenceSusan Mani; Renuka R. NairDivision of Cellular & Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences & Technology

219Bryan MarshallCell Generated Complete Human Skin, a Wound Healing ModelXunwei Wu (1); Minh Vo (1); Bryan Marshall (1)MWV Cell

220Vanessa RagagliaAn Acellular Biodegradable Scaffold for Tendon Regeneration in a Rabbit Pre-Clinical ModelVanessa Ragaglia; Priya R. BaraniakResearch Operations, Garnet BioTherapeutics, Inc.

221Jason SchulteDecellularized and Vascularized Scaffolds for Tissue-Engineered Regeneration of MyocardiumJason B Schulte (1); Dan T. Simionescu (2); Agneta Simionescu (2)Bioengineering, Clemson University (1); Patewood/CU Bioengineering Translational Research Center, CUBEInc (2)

222Young-Doug SohnEnhanced Wound Repair by Novel Circulating Human Lymphatic Endothelial Progenitor Cells through Lymphatic NeovascularizationYoung-Doug Sohn (1); Woan-Sang Kim (1); Do Hyun Park (1); and Young-sup Yoon (1)Divisions of Cardiology, School of Medicine, Emory University (1)

223Jane TitteringtonEncapsulation of Mesenchymal Stem Cells to Improve Stem Cell Therapy Following Myocardial Infarction in RatsJane S. Titterington (1); Rebecca Levit (1); Giji Joseph (1); Kiyoko Takemiya (1); Milton Brown (1); Devon Headen (2); Susan Safley (3); Collin J. Weber (3); Michael E. Davis (1,2); Andrés J. García (2); W. Robert Taylor (1,2,4)Division of Cardiology, Emory University (1); Department of Biomedical Engineering, Georgia Institute of Technology (2), Department of Surgery, Emory University (3); Division of Cardiology, Atlanta Veterans Administration Medical Center (4)

224Jason WertheimChanging Times in Solid Organ Transplantation and the Role of Tissue Engineering to Develop Replacement Organs for Patients in NeedJason A. Wertheim, MD, PhD (1, 2)Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, Illinois (1); Institute for BioNanotechnology in Medicine and Chemistry of Life Processes Institute, Northwestern University, Chicago, Illinois (2)

225Qian YeIn Vitro and In Vivo Evaluation of Placenta Derived Adherent Cells Cultured on Decellularized Human Placental Vascular ScaffoldQian Ye; Jia-Lun Wang; Xuan Guo; Xiaowei Deng; Joseph Gleason; Shuyang He; Uri Herzberg; Mohit B. Bhatia; Wolfgang T. Hofgartner; Robert J. Hariri

226Xiao ZhaoThe Role of Neural Precursor Cells and Self Assembling Peptides in Spinal Cord RepairXiao Zhao (1); Gordan Liu (2); Yang Liu (2); Jian Wang (2); Kajana Satkunendrarajah (2); Michael Fehlings (2,3)Department of otolaryngology - head and neck surgery, University of Toronto, Ontario, Canada (1); Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada (2); Institute of Medical Sciences, University of Toronto, Ontario, Canada (3)

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249Beth PollotEvaluation of Scaffolds for Treating Volumetric Muscle LossBeth E. Pollot (1,2); Christopher R. Rathbone (2); Joseph C. Wenke (2); Teja Guda (1,2)Biomedical Engineering, The University of Texas at San Antonio (1); Extremity Trauma and Regenerative Medicine, United States Army Institute of Surgical Research (2)

250Wen SeetoEndothelial Progenitor Cell Retention and Rolling on PEG-peptide Hydrogels Exposed to ShearWen J. Seeto (1); Yangzi Tian (2); Elizabeth A. Lipke (1)Chemical Engineering, Auburn University (1); Chemical and Biomolecular Engineering, Polytechnic Institute of New York University (2)

251Emily ShearierPre-vascularized Cell SheetsEmily R. Shearier (1); Lijun Zhang (1); Zhaoqiang Zhang (1); Feng Zhao (1)Biomedical Engineering, Michigan Technological University (1)

252Sami SomoVascularized Tissue Formation in Gradient Biomaterials is Controlled by Pore InterconnectivitySami Somo (1,3); Banu Akar (1,3); Jeffery C. Larson (1,3); Alyssa A. Appel (1,3); Hamidreza Mehdizadeh (2); Ali Cinar (2); Eric M. Brey (1,3)Biomedical Engineering, Illinois Institute of Technology (1); Chemical Engineering, Illinois Institute of Technology (2); Edward Hines Junior Veterans Administration Hospital (3)

253Aline ThomasLentivirus-mediated Sonic Hedgehog Delivery for Vascularization of Poly(ethylene glycol) Scaffolds In VivoAline Thomas (1); Andrew Gomez (1); Lonnie Shea (2)Biomedical Engineering, Northwestern University (1); Chemical and Biological Engineering, Northwestern University (2)

254Lei TianImpact of Pericytes On Vessel Formation and Anastomosis In Prevascularized TissuesLei Tian (1,2); Anna S. Aledia (1,2); Christopher C.W. Hughes (1,4); and Steven C. George (1,2,3)Department of Biomedical Engineering, University of California, Irvine (1); The Edwards Life Sciences Center for Advanced Cardiovascular Technologies, University of California, Irvine (2); Department of Chemical Engineering and Materials, University of California, Irvine (3); Department of Molecular Biology and Biochemistry, University of California, Irvine (4)

255Jing YangFabrication of Vascularised Tissues using 3D PrintingJing Yang; Kevin Shakesheff School of Pharmacy, University of Nottingham

256Daniel YoungRole of VEGF-mimetic Peptide Presentation for the Vascularization of Hydrogel ScaffoldsDaniel A. Young (1); Elizabeth J. English (1); Georgia Papavasiliou (1)Biomedical Engineering Department, Illinois Institute of Technology (1)

257Chao ZhangEnhance Myogensis and Innervation after Implantation of Urine-Derived Stem Cells Expressing VEGF in Collagen-I HydrogelChao Zhang, Guihua Liu, Shantaram Bharadwaj, Anthony Atala and Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine Winston-Salem, North Carolina

LATE BREAKING POSTERS258Samuel LoPrestiEffect of Extracellular Matrix Source Tissue on Remodeling of Temporomandibular Joint Meniscus ReplacementSamuel LoPresti (1,2); William Chung (2,3); Alejandro Almarza (1,2); Stephen Badylak (2,4); Bryan Brown (1,2)Bioengineering, University of Pittsburgh (1); McGowan Institute for Regenerative Medicine (2); Oral and Maxillofacial Surgery, University of Pittsburgh (3); Surgery, University of Pittsburgh (4)

259Kouji ShimaHydrostatic Pressure Treatment for making Acellular Dermis GraftsKouji Shima (1); Liempham Hieu(2); Atsushi Mahara (3); Naoki Morimoto (2,4); Tetsuji Yamaoka (3); Shigehiko Suzuki (2); Toshiya Fujisato (1);Department of Biomedical Engineering, Osaka Institute of Technology (1); Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University (2); Department of Biomedical Engineering, National Cerebral and Cardiovascular Center (3); Department of Plastic and Reconstructive Surgery, Kansai Medical University Takii Hospital (4)

260Carlos LandaMobilized Mesenchymal Stem Cell Cultures from Ovine Peripheral BloodCarlos Landa-Solís (1); Carmina Ortega-Sanchez (1) Julio Granados-Montiel (1) , Anell Olivos-Meza (2); Hugo Lecona-Butrón (3); Clemente Ibarra-Ponce de Leóna,(1,2,4); Carlos Pineda-Villaseñor (5)Tissue Engineering, Cell Therapy and Regenerative Medicine Unit (1); Sports Orthopaedics and Arthroscopy Department (2); Animal Care Facility (3); Biotechnology Department (4); Research Direction; National Institute of Rehabilitation, Mexico City, Mexico (5)

261Yijun LiuAnalysis of Human Mesenchymal Stem Cell Metabolism during Expansion and Osteogenic Differentiation under Different Oxygen TensionsYijun Liu (1); Nathalie Muñoz (2); Teng Ma (1)Chemical and Biomedical Engineering, Florida State University(1); Chemistry, Florida State University (2)

262Shunya TakagiEffect of Electrical Stimulation of Tissue-Engineered Skeletal MuscleShunya Takagi (1); Shouhei Hatoma (1); Takafumi Kamon (1); Tomohiro Nakamura (2); Toshia Fujisato (1)Department of Biomedical Engineering, Osaka Institute of Technology (1); Division of Human Sciences, Section for Health-related Physical Education, Faculty of Engineering, Osaka Institute of Technology (2)

263Ang-Chen TsaiHuman Mesenchymal Stem Cells in 3D Aggregates: Influence of Endogenous Extracellular Matrix and Aggregate Size on Cell SurvivalAng-Chen Tsai; Junho Kim; Teng MaChemical and Biomedical Engineering, Florida State University

264Julia RaykinA Theoretical and Experimental Model to Predict Failure of Tissue Engineered Blood VesselsJulia Raykin (1,2); Alexander I. Rachev (3); Rudy L. Gleason (1,2,3)Department of Biomedical Engineering, Georgia Institute of Technology (1); Petite Institute for Bioengineering and Biosciences, Georgia Institute of Technology (2); and School of Mechanical Engineering, Georgia Institute of Technology (3)

265Aaron MohsMagnetic Resonance Imaging Characterization of Regenerating Bladder in a Murine Subtotal Cystectomy ModelAaron M. Mohs (1,2); Mona Zarifpour (1); Sneha Kelkar (1); Martha A. Kahlson (1); Frank C. Marini (1); George J. Christ (1,2)Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (1); Wake Forest - Virginia Tech School of Biomedical Engineering and Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina

266Sudharsan Periyasamy-ThandavanDifferential Expression of MicroRNAs in Human Mesenchymal Stem Cells with Age May Be Related to Musculoskeletal DisordersSudharsan Periyasamy-Thandavan (1,3); Sergi Mas (2); Sadanand Fulzele( 5); Xingming Shi( 6,7); Norman Chutkan (5); Randy Ruark (5); John Hinson (5); Monte Hunter (5); Raymond Corpe (5); Hongyan Xu (4); Carlos Isales( 5,6,7); Mark W. Hamrick (3,5,6,7); William DeeCharlie Norwood Veterans Administration Medical Center, Augusta, Georgia (1); Universitat de Barcelona, Spain, the Departments of (3); Cellular Biology and Anatomy (3); Biostatistics and Epidemiology (4); Orthopaedic Surgery, and the Institutes of (5); Molecular Medicine and Genetics and (6); Regenerative and Reparative Medicine, Georgia Regents University, Augusta, Georgia (7)

267Karin WartellaAn e-Incubator for Dynamic Magnetic Resonance Microscopy of Bone Tissue EngineeredKarin A Wartella (1); Vahid Khalilzad-Sharghi (1); Shadi F Othman (1); Huihui Xu (1)Department of Biological Systems Engineering, University of Nebraska-Lincoln (1)

268Parvin ForghaniMDSCs Modulation by Silibinin in Murine Breast Tumor ModelParvin Forghani (1,2); Edmund K Waller (2);School of Public Health, Department of Pathobiology, Tehran University of Medical Sciences, Tehran, IR(1); Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia (2)

269Susanna MiettinenImmunological Evaluation of Human Adipose Stem Cells Cultured in Different Serum Conditions versus Xenofree/Serumfree ConditionSusanna Miettinen (1); Mimmi Patrikoski (1); Jyrki Sivula (1); Bettina Mannerström (1)Adult Stem Cell Group, Institute of Biomedical Technology and BioMediTech, University of Tampere, Tampere, Finland (1)

270Debora PetropolisEngineering a Hepatic In Vitro 3D Model to Study Human Parasitic InfectionDebora B. Petropolis (1); Nancy Guillen (1)Cell Biology of Parasitism Unit, Institut Pasteur, Paris, France (1)

271Gabriela Piñón ZárateGK-1 Improves the Immune Response of Bone Marrow Dendritic Cells Target with MAGE Antigen in Mice with MelanomaGabriela Piñón (1); Beatriz Hernández (1); Miguel Herrera (1); Katia Jarquín (1); Patricia Torres(1); Daniel Santillán (1); Paulina Villena (1); Marlene Zempoaltecatl (1); Sandra Acevedo (1); Andres Castell (1)Laboratory of Immunotherapy, Cell Biology Department, Medicine School, Mexico City, Mexico (1)

272Filippos TourlomousisInvestigation of Cell-scaffold Dimensional Metrology using 3D Melt-electrospun ScaffoldsFilippos Tourlomousis (1); Robert C. Chang (2)Mechanical Engineering, Stevens Institute of Technology (1); Mechanical Engineering, Stevens Institute of Technology (2)

273Andrés Castell RodríguezGrafts of Human Cadaveric Cancellous Bone Chips Seeded with Autologous Osteoblasts to Treat Diaphyseal PseudoarthrosisAndres Castell (1); Miguel Herrera (1); Beatriz Hernández (1); Judith Alvarez (1); Gabriela Piñon (1); Katia Jarquin (1); Sandra Acevedo (1); Pablo Castell (2); Sergio Guevara (2); Teofilo Bandera (2); Raul Flores (3); Francisco Limon(3); Enrique Obermeier (3); Department of Cell and Tissue Biology, Medicine School, Universidad Nacional Autónoma de México, México City, México (1); Hospital General, ISSSTE, Iguala Gro. and Sanatorio de Padre Jesús, Iguala, Gro, Mexico (2); Tissue Bank Novoinjertos, México City, México (3)

274Pamela BrownBaerSpatial Bone Healing Patterns in a Bone Notch Defect Model in Pigs: A Clinical CT AnalysisPamela R. BrownBaer (1); David T. Silliman (1); Robert G. Hale (1); Teja Guda (1,2)United States Army Institute of Surgical Research (1); University of Texas at San Antonio (2)

275Laura McCallumMetabolic and Structural Changes in Diabetic Cardiomyopathy; In Vivo and In Vitro ModelsLaura McCallum; Thomas Larrew; James Chow; Jason Schulte; Dan Simionescu; Agneta SimionescuBioengineering, Clemson University

276Denys LisovyyIn Vivo Tissue-Engineered Artificial Skin Grown to Resemble the Native SkinDenys E. Lisovyy; Sergey M. ChudnykhMoscow State University of Medicine and Dentistry

277Denys LisovyyAutologous Cells Of Hair Follicles as an Alternative to Hair Transplantation. Clinical Results.Denis E. Lisovyy (1,2); Elena L. Vilitkevich (2); Sergey M. Chudnykh (1)General Surgery, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation (1); Experimental Cardiology, Russian Cardiology Research and Production Complex, Moscow, Russian Federation (2)

278Paul SchillerNon-Expanded MIAMI (ne-MIAMI) Cells Directly Isolated from Human Bone Marrow:Characterization, Interaction with Scaffolds and Therapeutic ApplicationsGianluca D’Ippolito, (1,2); Gaetan J.R. Delcroix (1,2); H. Thomas Temple (1); Paul C. Schiller (1,2)University of Miami (1); Bruce W. Carter Miami Veterans Administration Healthcare System, Miami, Florida (2)

279Keith VanDusenEngineered Skeletal Muscle Units for Repair of Volumetric Muscle Loss in the Tibialis Anterior Muscle of a RatKeith W. VanDusen (1); Brian C. Syverud (2); Lisa M. Larkin (1,2)Molecular & Integrative Physiology, University of Michigan (1); Biomedical Engineering, University of Michigan (2)

280Mona ZarifpourCharacterization of Functional Bladder Regeneration in MiceMona Zarifpour (1); Jason M Sandberg (1); Manasi Vadhavkar (1); Sneha Kelkar (1); Aaron M. Mohs (1,2); Frank C. Marini (1); Karl-Erik Andersson (1); George J. Christ (1,2)Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina (1); Wake Forest – Virginia Tech School of Biomedical Engineering and Sciences, Winston Salem, North Carolina (2)

281Goro KuramotoPreventive Effect of Oral Mucosal Epithelial Cell Sheets on Endometrial AdhesionGoro Kuramoto (1,2); Soichi Takagi (2); Ken Ishitani (1); Tatsuya Shimizu (2); Masayuki Yamato (2); Teruo Okano (2); Hideo Matsui (1)Department of Obstetrics and Gynecology, Tokyo Women’s Medical University (1); Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University (2)

282Mohammad Reza DastouriIn Vitro Differentiation of Endothelial Progenitor Cells Generated From Mouse Induced Pluripotent Stem Cells Mohammad Reza Dastouri (1); Aynur Karadag (2); Deniz Balci (1); Gunseli cubukcuoglu Deniz (1); Serkan Durdu (3); Ahmet Ruchan Akar (3); Alp Can (4)Department of Stem Cell, Ankara University Biotechnology Institute, Ankara, Turkey (1); Department of Medical Biology, Ankara University, Ankara, Turkey (2); Department of Cardiovascular Surgery, Heart Center, Ankara University, Ankara, Turkey (3); Department of Histology & Embryology, Ankara University School of Medicine, Ankara, Turkey (4)

283Seung-Yup KuFunctional Alterations in Human Pluripotent Stem Cell-Derived Cardiomyocyte due to In Vitro Culture and Reversing Effect of Vitamin CSeung-Yup Ku (1,2); Yoon Young Kim (1,2); Seok Hyun Kim (1,2); Young Min Choi (1,2)Institute of Reproductive Medicine and Population, Medical Research Center, Seoul, Korea (1); Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea (2)

284Yonggang PangAnalyzing Structure and Function of Vascularization in Engineered Bone Tissue by Video-rate Intravital Microscopy and 3D Image ProcessingYonggang Pang (1); Craig M. Neville (1); Brian E. Grottkau (1)Department of Orthopaedic Surgery, Massachusetts General Hospital (1)

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November 2013 Dear Students, Young Investigators, and Conference Attendees, Welcome to Atlanta and thank you for joining us at TERMIS-AM 2013! The TERMIS Student and Young Investigator Section Americas (SYIS-AM) Meeting Committee has prepared a special program for students and post-docs to foster career development and encourage networking and interaction with experts in the field. We hope you enjoy our program and find it stimulating! The SYIS program opens on Sunday afternoon with tours of Georgia Institute of Technology’s research laboratories. Enjoy a Stinger Shuttle ride from the Hyatt downtown to Georgia Institute of Technology’s campus in midtown. You will then get to walk through some biomedical research laboratories and hear about the cutting-edge research going on at Georgia Institute of Technology.

Events continue throughout the day on Monday beginning with a Career Panel Discussion over lunch (sign-ups at registration). Come hear about career paths from experts in academia, industry and the NIH. Monday afternoon SYIS-AM is taking part in an outreach program to expose Atlanta high-school students to a scientific conference. We will be demonstrating biomedical principles to these students through hands-on demonstrations. On Monday evening, the SYIS is hosting a reception Alma Cocina. This will be an opportunity to network with fellow SYIS attendees as well as join us at our SYIS-AM Business Meeting. Come and enjoy drinks and hors d’oeuvres, meet new people, and learn how you can be a part of SYIS and the future of regenerative medicine!

On Tuesday, join us for the Student Meet Mentor Lunch (sign-ups at registration). Don’t miss this opportunity to have lunch and talk with leaders in the field of regenerative medicine. SYIS is excited to host the SYIS-AM Poster Competition. The top 25 student and young investigator posters (authors were notified prior to the conference) will be judged by senior faculty members, with awards for 1st place ($300), 2nd place ($200), and 3rd place ($100). Poster award winners will be announced at the closing ceremony on Wednesday at 4:30pm. This year we have been able to expand our events by including more conference attendees as well as adding new events such as our SYIS Outreach Program. We would like to thank the NSF for a grant in support of these expansion efforts, as well the Stem Cell Engineering Center at Georgia Institute of Technology and the Regenerative Engineering and Medicine Research Center at Georgia Institute of Technology and Emory University for their sponsorship of the lab tours and poster awards.

We hope you have a fantastic TERMIS-AM Meeting and look forward to meeting you! Kind Regards,

Rebecca DahlinSYIS-AM Chair Satyavrata SamavediSYIS-AM Secretary Johnny LamSYIS-AM Treasurer

Tracy HookwaySYIS-AM Vice Chair

Sean MurphySYIS-AM Professional Development Committee Chair

Kimbery FerlinSYIS-AM Communications Officer

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eCONGRATULATIONS TO THE TERMIS-AM 2013 CONFERENCE & EXPOSITION PLANNING TEAM

Robert Guldberg, PhD, Conference Chair and TERMIS-AM Chapter Chair, Georgia Institute of Technology

Todd McDevitt, PhD, Scientific Advisory Committee Chair, Georgia Institute of Technology

Megan McDevitt, CMP, Local Arrangements Chair, Georgia Institute of Technology

Tracy Hookway, PhD, SYIS-AM Vice-Chair, Georgia Institute of Technology

Executive Production Provided byForecast Technology Groupwww.conferencestrategists.comAnita Caufield, MHAAndrea Lubienski, CMPGina Saxton

Conference Liaison for TERMISSarah Wilburn, TERMIS Administrator

TERMIS-AM TreasurerBill Tawil, Baxter BioScience & UCLA

Special thanks to Bob Nerem, PhD, Georgia Institute of Technology for organizing the Opening Symposium - “Tissue Engineering & Regenerative Medicine: Origins and its Evolution”.

Mark van Dyke, PhD, Virginia Polytechnic Institute and State University, Tim Bertram, DVM, PhD, Tengion and the TERMIS-AM Industry Committee for organizing the Bench to Business Workshop.

Milica Radisic, PhD, University of Toronto, for organizing the Women in Tissue Engineering & Regenerative Medicine Luncheon.

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DISCLAIMERThe material presented at the TERMIS-AM 2013 Conference has been made available by the Tissue Engineering and Regenerative Medicine International Society - Americas (TERMIS-AM) for educational purposes only. The material is not intended to represent the only, nor necessarily best, method or procedure appropriate for the medical situations discussed, but rather is intended to present an approach, view, statement or opinion of the faculty which may be helpful to others who face similar situations. Tissue Engineering and Regenerative Medicine International Society - Americas (TERMIS-AM) disclaims any and all liability for injury or other damages resulting to any individual attending the meeting and for all claims which may arise out of the use of the techniques demonstrated therein by such individuals, whether these claims shall be asserted by physician or any other person.

NOTICENo part of this publication may be translated or reproduced, in any form or by any means, without written permission from TERMIS-AM. No photography, video, audio recording or reproduction of any kind may be used during any portion of the TERMIS-AM 2013 Conference. TERMIS-AM reserves all of its rights to such materials, and commercial recording or reproduction is specifically prohibited. This includes, but is not limited to, digital and film photography, videography, cellular phones, and other image or audio recording devices.

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TERMIS-AM STUDENT & YOUNG INVESTIGATOR SECTION (SYIS)

Campus Tours Sunday, November 10th from 12:00 – 2:00 PM TERMIS-AM SYIS is pleased to host Tours of the Georgia Institute of Technology Campus on Sunday, November 10th during the TERMIS-AM Atlanta Meeting. This year SYIS-AM will be offering the chance to visit the campus of Georgia Institute of Technology and tour the research laboratories. Transportation will be provided from the conference center to the campus.

Career Opportunities Discussion Panel Monday, November 11th at 11:30 AM The Learning Center TERMIS-AM SYIS is pleased to host the Career Opportunities Discussion Panel on Monday, November 11th at lunch during the TERMIS-AM Atlanta Meeting. This discussion panel will consist of scientific leaders representing careers in academia, industry, government agencies and institutes and entrepreneurial activities. This is a great opportunity for students and young investigators to hear these experienced scientists discussing their own career paths, the opportunities and challenges of their chosen career, and providing advice on how you can achieve your career goals. This interactive panel is designed to facilitate open discussion, and to allow students and young investigators to have their questions answered by the panel and other attendees. At previous meetings, this event has been very beneficial for students and young investigators thinking about pursuing a career in any of these fields.

Academia George J. Christ, Ph.D. Professor of Regenerative Medicine, Urology, Physiology & Pharmacology and Translational Science Core Faculty Member, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences Wake Forest Institute for Regenerative Medicine Industry Mark Van Dyke Associate Professor School of Biomedical Engineering and Sciences Virginia Tech Government agencies and institutes Rosemarie Hunziker, PhD Tissue Engineering/Regenerative Medicine, Biomaterials, and Implantable Medical Devices Program Director National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Entrepreneurial activities Anthony Ratcliffe, PhD President and CEO Synthasome, Inc

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Opening Reception Monday, November 11th 7:00 PM at Alma Cocina TERMIS-AM SYIS is pleased to host the Opening Reception on the evening of Monday, November 11th to celebrate the opening of the 2013 TERMIS-AM Meeting in Atlanta. The SYIS reception is open to all students and young investigators and will be a fun evening to kick-off the TERMIS-AM meeting. This event is an opportunity to catch up with friends and meet other young scientists while enjoying food and drinks. We will also hold our annual business meeting and discuss the purpose and goals of the SYIS-AM for the 2013 conference, as well provide information on the upcoming SYIS events.

Student Meet Mentor Lunch Tuesday, November 12th at 11:30 AM Hanover AB TERMIS-AM SYIS is pleased to host the Student Meet Mentor Lunch on Tuesday, November 12 at lunch during the TERMIS-AM Atlanta Meeting. The Student Meet Mentor Lunch gives students and young investigators the opportunity to enjoy an invigorating lunch with a mentor of your choice. Mentors include session chairs, members of the Scientific Advisory Committee, and local industry leaders.

Student Poster Awards Presented at the Closing Ceremony on November 14th at 4:30 PM Centennial 3 Cash prizes will be handed out again this year for the best posters among students and young investigators. This is your chance to achieve special recognition among your peers and to earn some bonus winnings for your research efforts and success.

Student Poster Awards are sponsored by:

Student Co-Chairing (throughout the conference) TERMIS-AM SYIS is pleased to announce the opportunity for students and young investigators to serve as co-chairs for scientific sessions at the TERMIS-AM Atlanta Meeting in November. This one-of-a-kind event provides a unique platform for students and young investigators to co-chair sessions with leading scientists and get first-hand experience moderating scientific discussions. At previous meetings, this event has been hugely popular, and we hope to see several of you co-chairing sessions at this year’s meeting.

STUDENT POSTER COMPETITION – POSTERS ARE FOUND IN THE TERRACE FOYER

1 ImmunomodulationJames ChowImmunomodulatory Effects of Autologous Adipose-Derived Stem Cells on Scaffold Remodeling in DiabetesJames P. Chow (1); Harleigh J. Warner (1); Dan T. Simionescu (1); Agneta Simionescu (1)Bioengineering, Clemson University (1)

2 Engineering MorphogenesisKaty HammersmithEngineering the Microenvironment of Embryoid Bodies via Heparin-modified Gelatin Microparticle IncorporationKaty A. Hammersmith(1); Andres M. Bratt-Leal(1); Marissa T Cooke (1); Christian Mandrycky(1); Todd C. McDevitt (1,2)Biomedical Engineering, Georgia Institute of Technology(1); The Parker H. Petit Institute for Bioengineering & Bioscience, Georgia Institute of Technology (2)

3 Rejuvenating Tissue/Organ FunctionChristopher HeylmanEvaluation of the in vitro performance of human osteogenic connective tissue progenitor cells derived from bone versus fat at clinically relevant oxygen tensionsChristopher M Heylman (1), Cynthia Boehm (1), George F Muschler (1)Biomedical Engineering Department, Cleveland Clinic Lerner Research Institute (1)

4 Engineering of Matrix CompositionHenk HoogenkampBioscaffolds for organs in one: large seamless hollow collagen spheres for organ regenerationHenk Hoogenkamp (1); Michiel Pot (1); Yi Sun (2); Dorien Tiemessen (3); Wout F. Feitz (3); Willeke F. Daamen (1); Toin H. van Kuppevelt (1)Department of Biochemistry, Radboud University Medical Centre (1); Department of Radiology, Radboud University Medical Centre (2); Department of Urology, Radboud University Medical Centre (3)

5 VascularizationDaphne HuttonVascularized Bone Development Within Composite ScaffoldsDaphne L Hutton (1); Josh Temple (1); Erika M Moore (1); Ben P Hung (1); Warren L Grayson (1)Biomedical Engineering, Johns Hopkins University (1)

6 Rejuvenating Tissue/Organ FunctionCarlos Kengla3-D Integrated Organ Printing for Ear ReconstructionCarlos V Kengla (1,2); Hyun-Wook Kang (1); Anthony Atala (1); Sang Jin Lee (1,2); James J Yoo (1,2)Wake Forest Institute for Regenerative Medicine, Wake Forest University (1); School of Biomedical Engineering and Sciences, Wake Forest University, Virginia Tech (2)

7 Rejuvenating Tissue/Organ FunctionJoshua Jaeyun KimA Novel Enzyme Degradable Hydrogel Based Cell Sheet Harvest and Transfer System with High Cell ViabilityJoshua Jaeyun Kim (1); Joyce Wong (1)Biomedical Engieering, Bosotn University

8 Cell Engineering/Synthetic BiologyNaJung KimCombination of Small RNAs Enhances Muscle DevelopmentNaJung Kim (1); James J. Yoo (2); Anthony Atala (3); Sang Jin Lee (4)Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Wake Forest University

9 Regeneration-Inducing BiomaterialsGaurav LalwaniCytocompatibility of Macroporous All-Carbon scaffolds for Tissue Engineering ApplicationsGaurav Lalwani, Yahfi Talukdar, Balaji SitharamanDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794-5281

10 Manufacturing Technologies and PlatformsHui Chong LauEfficient Stem Cell Delivery System at Room TemperatureHui-Chong Lau (1); In-Ho Jo (2); Jeong-Ok Lim (1)Department of Biomedical Science, Biomedical Research Institute, Kyungpook National University, Daegu, Korea (1); Department of Molecular Medicine, Ewha Womans University Medical School, Seoul. Korea (2)

11 Cell Engineering/Synthetic BiologyDiana OlveraCoating of Titanium with Electrically Polarized Hydroxyapatite Modulates Mesenchymal Stem Cell AdhesionDiana Olvera (1); Keith Savino (2); Jason A. Inzana (1); Matthew Z. Yates (2); Hani A. Awad (1)Biomedical Engineering, University of Rochester (1); Chemistry, University of Rochester (2)

12 ImmunomodulationSravanti RangarajuTargeting Trogocytosis: A Novel Strategy to Reduce Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplant by Inhibiting the Generation of Cross-Dressed Dendritic CellsSravanti Rangaraju;Junghwa Choi;Cynthia R Giver;Edmund K WallerEmory University

13 Cell Engineering/Synthetic BiologyRodrigo RezendeBiofabrication of tissue spheroids encaged into interlockable microscaffolds (lockyballs) using two photon polymerization and high cell density seeding in micromolded non-adhesive hydrogelRodrigo A Rezende (1); Karina R da Silva (2); Frederico Pereira (1); Vladimir Kasyanov (3); Aleksander Ovsianikov (4); Jurgen Stampfl (4);

Radovan Borojevich (5); Jose Mauro Granjeiro (2); Leandra Baptista (2,6); Jorge VL da Silva (1); Vladimir Mironov (1Division of 3D Technologies, Renato Archer Center for Information Technology, Campinas, SP, Brazil (1); Division of Bioengineering, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, RJ, BRAZIL (2); Riga Stradins University

14 Engineering of Matrix CompositionTara SBioengineered Fibrin Matrix for In vitro differentiation of Circulating progenitors to Neurons and In vivo survival in Rat Spinal cord Injury ModelTara.S (1); Lissy.K Krishnan (1)Thrombosis Research Unit, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum-695012, Kerala, India (1)

15 Rejuvenating Tissue/Organ FunctionLaura StruzynaRestoring Brain Circuitry Using Micro-Tissue Engineered Neural NetworksLaura A. Struzyna (1); John A. Wolf (1); James P. Harris (1); Constance J. Mietus (1); Joseph P. Morand (1); D. K. Cullen (1)Neurosurgery, University of Pennsylvania (1)

16 Drug Delivery PrinciplesDenise SullivanpNIPMAm Microparticles for Controlled BMP-4 DeliveryDenise D. Sullivan (1); Shalini Saxena (2); Anh H. Ngyugen (3); Jeff C. Gaulding (4); L. Andrew Lyon (3,4); Todd C. McDevitt (1,3)Biomedical Engineering, Georgia Institute of Technology and Emory University (1); Materials Science and Engineering, Georgia Institute of Technology (2); Bioengineering and Bioscience, Georgia Institute of Technology (4);Chemistry and Biochemistry, Georgia

17 Rejuvenating Tissue/Organ FunctionJillian Tengood HillmanFunctionalization of Endothelial Cells with Biodegradable Magnetic Nanoparticles for Targeted DeliveryJillian E Tengood (1); Ivan S. Alferiev (1); Robert J. Levy (1); Michael Chorny (1)(1) Cardiology, Children’s Hospital of Philadelphia

18 Preclinical Animal ModelsDavid BurmeisterDevelopment of a Porcine Deep Partial Thickness Contact Burn Model for Testing Tissue Engineered Wound Healing ProductsDavid M. Burmeister (1); Daniel C. Roy (1); Bridget M. Ford (1); Shanmugasundaram Natesan (1); Robert J. Christy (1)United States Army Institute of Surgical Research, Extremity Trauma Research and Regenerative Medicine (1)

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WFIRM YOUNG INVESTIGATOR AWARD WINNERS

Wake Forest Institute for Regenerative Medicine Young Investigator Award TERMIS-AM 2013 Conference and Exposition

The Wake Forest Institute for Regenerative Medicine is committed to the development and dissemination of novel therapies for the repair and replacement of diseased tissues and organs. One way to achieve this goal is to foster the careers of young investigators to encourage them to find solutions to problems in regenerative medicine. As part of this effort, the Wake Forest Institute for Regenerative Medicine Young Investigator Award was first awarded at the TERMIS-NA Conference and Exposition in 2008. The award is designed to recognize outstanding achievements by members of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) who are in the early stages of a career in regenerative medicine.

The award consists of a certificate, $2500 cash prize, and recognition at the 2013 TERMIS-AM Conference and Expo. We are pleased to announce this year’s winners:Dr. Minh Khanh Nguyen, PhD and Ms. Melissa A. Kinney

Minh Khanh Nguyen, PhD, received his B.S.E. in Chemical Engineering from Ho Chi Minh City University of Technology, Vietnam, in 2003. Minh then went to graduate school at Sungkyunkwan University, South Korea in 2005 and graduated with a Ph.D. in Polymer Science and Engineering in 2010 under the supervision of Dr. Doo Sung Lee. His graduate training was in design, synthesis and characterization of biomaterials for bioactive factor delivery. Following his graduate studies, he has been working as a Postdoctoral Research Fellow in the Alsberg Stem Cell and Engineered Novel Therapeutics laboratory in Department of Biomedical Engineering at Case Western Reserve University. Under the guidance of Dr. Eben Alsberg, he develops hydrogel biomaterial systems for controlled, sustained and localized delivery of genes to guide stem cell differentiation. His research interests lie in developing new biomaterials for bioactive factor delivery for tissue regeneration applications.

Melissa Kinney graduated with a Bachelor of Science in biomedical engineering from Boston University in 2008. She is now an American Heart Association Predoctoral Fellow and Ph.D. Candidate in Biomedical Engineering at Georgia Institute of Technology and Emory University where she is a senior member of the Engineering Stem Cell Technologies Laboratory led by Todd McDevitt. Melissa’s research interests integrate interdisciplinary perspectives from chemical and mechanical engineering with stem cell and developmental biology and aim to develop technological advances for the integration of stem cells in translational regenerative applications. Her research specifically studies the morphogenesis of stem cells within three-dimensional microtissues to elucidate of the spatiotemporal dynamics of cell intrinsic interactions and signaling mediating tissue patterning, which will ultimately enable the development of novel strategies to engineer functional tissue structures. Her research in stem cell biology and engineering has earned recognition through National Science Foundation and American Heart Association fellowships, the Petit Institute for Bioscience and Bioengineering F.L. Bud Suddath Award and a Top Poster Award at the Society for Biological Engineering International Conference on Stem Cell Engineering. Melissa has authored eight publications, a textbook chapter, and presented her work at international conferences in the fields of biomedical engineering, regenerative medicine and stem cell biology.

Congratulations to Mihn and Melissa!

TERMIS-AM AWARDS PROGRAM - 2013 AWARDEES

The TERMIS-AM Council and Awards Committee would like to announce the recipients of the 2013 TERMIS-AM awards program. Each of the awardees will be acknowledged during this year’s conference. Congratulations!

Lifetime Achievement Award: Robert M. Nerem, PhD, Professor Emeritus, George W. Woodruff School of Mechanical Engineering, Director, Georgia Institute of Technology & Emory Center for Regenerative Medicine, Parker H. Petit Distinguished Chair for Engineering in Medicine and Institute Professor, Georgia Institute of Technology. Dr. Nerem has been active in bioengineering for more than thirty-five years.

His initial interest was motivated by the possible role of fluid dynamics in atherosclerosis, and he has conducted fundamental research on problems in cardiovascular fluid dynamics. In 1981 he established a cell culture laboratory and began to study the influence of physical forces on anchorage-dependent mammalian cells, with much of this work focusing on the cells which make up a blood vessel.

This work led to his interest in tissue engineering, and he now is director of the Georgia Institute of Technology/Emory Center for the Engineering of Living Tissues (GTEC), an Engineering Research Center established in 1998 and funded by the National Science Foundation. From 1995 to 2009 Nerem served as the director of the Parker H. Petit Institute for Bioengineering and Bioscience (IBB), a research institute whose mission is to integrate engineering, information technology, and the life sciences in the conduct of biomedical research.

In addition, he served on a part-time basis from 2003 to 2006 as the senior advisor for bioengineering in the National Institute of Health’s (NIH) newest institute, the National Institute for Biomedical Imaging and Bioengineering. In recognition of his work, he was elected to the National Academy of Engineering in 1988 and to the Institute of Medicine of the National Academy of Sciences in 1992.

He was elected a fellow of the American Academy of Arts and Sciences in 1998. Nerem is past president of the International Federation for Medical and Biological Engineering and past president of the International Union for Physical and Engineering Sciences in Medicine. He was also the founding president of the American Institute of Medical and Biological Engineering and he served on the Science Board of the Food and Drug Administration from 2000 to 2003. In 2008 he received the Founders Award from the National Academy of Engineering.

Nerem came to Georgia Institute of Technology in the winter of 1987 as a professor in the School of Mechanical Engineering and as the Parker H. Petit Distinguished Chair for Engineering in Medicine. He also has an appointment in the School of Chemical and Biomolecular Engineering. Prior to coming to Georgia Institute of Technology, he was a professor and chairman in the Department of Mechanical Engineering at the University of Houston from 1979 to 1986 and on the faculty at the Ohio State University from 1964 to 1979.

Young Investigator Award: Alison P. McGuigan, PhD, Assistant Professor of the Department of Chemical Engineering and Applied Chemistry at the University of Toronto.

Dr. McGuigan is an Assistant Professor in Chemical Engineering and Applied Chemistry and the Institute for Biomaterials and Biomedical Engineering at University of Toronto. She obtained her undergraduate degree from University of Oxford, her PhD from University of Toronto working with Michael Sefton and completed post-docs at Harvard University with George Whitesides and Stanford School of Medicine with Jeffrey Axelrod.

Dr. McGuigan is a pioneer in the field of artificial tissue design and morphogenesis engineering. Her work uniquely combines tissue engineering, microfabrication and developmental biology to assemble tissue systems for regenerative medicine and drug screening applications. Specifically her team has created engineering tools to mimicking and quantitatively model tissue organizational processes that occur in the developing embryo. She has published 26 papers, a number of which have been key first demonstration contributions within the field appearing in journals such as PNAS, Nature Protocols, Biomaterials, Tissue Engineering and Integrative Biology. In recognition of her work Alison has received numerous awards: She received a Canadian Rhodes Scholarship from 2000-2002, a Canadian Institute of Health Training Program in Regenerative Medicine Fellowship in 2004, and a Stanford School of Medicine Dean’s Post-Doctoral fellowship in 2007. In 2008 Alison received the Wake Forest Institute of Regenerative Medicine Young Investigator Award in recognition of her work on modular tissue engineering. Since establishing her own lab in 2009, she has received over $1.27M in research funding from the Natural Science and Engineering research council of Canada (NSERC), the Heart and Stroke Foundation of Canada, the Canadian Institute of Health Research (CIHR), the Canadian Foundation for Innovation (CFI) and University of Toronto’s Connaught fund.

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TERMIS-AM AWARDS PROGRAM - 2013 AWARDEES

Senior Scientist Award: William R. Wagner, PhD, Director of the McGowan Institute for Regenerative Medicine and Professor of Surgery, Bioengineering and Chemical Engineering at the University of Pittsburgh. Dr. Wagner also serves as the Deputy Director of the NSF Engineering Research Center on “Revolutionizing Metallic Biomaterials”. He holds a B.S. (Johns Hopkins Univ.) and Ph.D. (Univ. of Texas) in Chemical Engineering. Dr. Wagner is the Coordinator for the Cellular and Organ Engineering track for Bioengineering graduate students, and currently teaches in the areas of biomaterials and tissue engineering.

Professor Wagner is the Founding Editor and Editor-in-Chief of one of the leading biomaterials journals, “Acta Biomaterialia”, and currently serves on the editorial boards of the “Journal of Biomedical Materials Research part A”, “Biotechnology and Bioengineering”, and the “Journal of Tissue Engineering and

Regenerative Medicine”. Dr. Wagner is also a past president of the American Society for Artificial Internal Organs (ASAIO; 2010-2011) and serves on the Executive Board of the International Federation of Artificial Organs (IFAO). He is a fellow and former vice president of the American Institute for Medical and Biological Engineering (AIMBE; 2000) and has also been elected a fellow of the Biomedical Engineering Society (2007), the International Union of Societies for Biomaterials Science and Engineering (2008) and the American Heart Association (2001). He has served as Chairman for the Gordon Research Conference on Biomaterials: Biocompatibility & Tissue Engineering as well as for the First World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS). In 2006 he was selected to the “Scientific American 50”, the magazine’s annual list recognizing leaders in science and technology from the research, business and policy fields. In 2011 he was awarded the Society for Biomaterials Clemson Award for Applied Research. He has served on numerous NIH and NSF study sections, is a member of the NIH College of Reviewers, and has been a member of external review committees for national and international organizations focused on bioengineering and regenerative medicine. His research has generated numerous patents and patent filings that have resulted in licensing activity, the formation of a company, and University of Pittsburgh Innovator Awards in 2007, 2008, 2009 and 2010.

Dr. Wagner’s research interests are generally in the area of cardiovascular engineering with projects that address medical device biocompatibility and design, tissue engineering, and targeted imaging. His research group is comprised of graduate students in Bioengineering and Chemical Engineering as well as post-doctoral fellows with backgrounds in surgery, polymer chemistry, or engineering. Dr. Wagner and his group enjoy working across the spectrum from in vitro to clinical studies. The McGowan Institute and the University of Pittsburgh Medical Center are uniquely positioned to allow such broad-based projects to flourish and complement one another. Researchers within Dr. Wagner’s group are afforded the opportunity to observe first-hand the clinical successes and failures of currently employed cardiovascular devices while concurrently working on projects that attempt to describe the current modes of failure, test solutions for the current device shortcomings, or develop technologies that may find application as future cardiovascular therapies. The front-line experience afforded by the clinical environment has proven invaluable in the learning experience of group members, not to mention the input such experience has on the creative environment.

Mary Ann Liebert, Inc. Outstanding Student Award: Rameshwar R. Rao, NSF Graduate Student Research Fellow, Department of Biomedical Engineering at the University of Michigan

Ram Rao received his undergraduate degree in biomedical engineering from the University of California - Davis in 2008 and did undergraduate research with Dr. Kent Leach. As in undergraduate student he was awarded the Department of Biomedical Engineering Outstanding Undergraduate Research Award and a University of California, Davis Human Corps Community Service Award.

He then moved on to the University of Michigan for his graduate students and received an MS and PhD in biomedical engineering in Dr. Jan Stegemann’s laboratory. His thesis worked focused using cell-based therapies to engineer vascularized bone tissue. During

his graduate students, Ram was funded by the Tissue Engineering and Regenerative Medicine T32 Training Grant and the National Science Foundation Graduate Research Fellowship. Ram was also awarded the Society for Biomaterials Award for Outstanding Research - Ph.D. Candidate in April of this year.

Ram is now currently a medical student at the University of Michigan and serves as one of the directors of the University of Michigan Student Run Free Clinic.

AABB Center for Cellular Therapies Booth No. 4Biomomentum Booth No. 27BioSpherix, Ltd. Booth Nos. 40 & 41Bose Corporation - ElectroForce Systems Group Booth No. 34

CellScale Biomaterials Testing Booth No. 19COMECER Booth No. 28Espin Technologies Booth No. 36Evonik Corporation Booth No. 11Flexcell International Corp Booth No. 16Fluidigm Booth No. 8Harvard Apparatus Regenerative Technology Booth No. 32

HypOxygen Booth No. 39IEEE Engineering in Medicine and Biology Society (EMBS) Booth No. 5

Instron Booth No. 10

IOP Publishing Booth No. 3Kaneka Booth No. 25Lifecore Biomedical Booth No. 35McGowan Institute for Regenerative Medicine Booth No. 2

Nitta Gelatin Booth No. 26NovaMatrix Booth No. 24Panasonic Healthcare Company of North America Booth No. 18

Parker H. Petit Institute for Bioengineering and Bioscience at Georgia Institute of Technology

Booth No. 17

RoosterBio / VitaCyte Booth No. 20Tissue Source Booth No. 9Trevigen Booth No. 33Wake Forest Institute for Regenerative Medicine Booth No. 1

Exhibit Hall Hours:

Sunday, November 10

7:00 PM - 9:00 PM

Monday, November 11

9:30 AM - 10:00 AM

11:30 AM - 1:00 PM

2:30 PM - 3:00 PM

4:30 PM - 6:00 PM

Tuesday, November 12

9:30 AM - 10:00 AM

11:30 AM - 1:00 PM

2:30 PM - 5:00 PM

EXIBITORS

Floor Plan & Booth Location

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EXHIBITORS

As the field regenerative therapies (CT) expands, so does AABB’s commitment to supporting the community of professionals. The AABB Center for Cellular Therapies (AABB CCT) is devoted to the development of programs, services and resources that are critical to donor and patient care, product safety and successful outcomes. AABB offers accreditation for product manufacturing and clinical administration of novel products. Visit the AABB CCT booth to learn more about our latest educational offerings in cellular and regenerative therapies and discover how you can get engaged! www.aabbcct.org

Biomomentum commercializes the Mach-1™, a mechanical tester capable of performing compression, tension, shear, friction, torsion, and viscosity tests for precise characterization of hydrogel, tissues, and soft materials. 2013 NEW FEATURE: The Mach-1™ can perform indentation testing on curved surfaces while automatically maintaining the indenter perpendicular to the surface. Biomomentum also offers biomechanical testing services. www.biomomentum.com

BioSpherix will be exhibiting the Xvivo System, world’s first and only barrier isolator optimized for cells. Economical and practical alternative to cleanrooms for cGMP compliant production of human cells for clinical use. Get better contamination control, better process control, better quality control, better pocketbook control. Stop by the BioSpherix booth. www.biospherix.com

The ElectroForce Systems Division of Bose Corporation is a leading supplier of mechanical testing instruments to research institutions, medical device manufacturers and engineering companies worldwide. Proprietary linear motor technology in Bose® test instruments provides exceptional performance, simplicity and efficiency in sterile and non-sterile applications for material characterization and biological stimulation. http://worldwide.bose.com/electroforce/

CellScale Biomaterials Testing -- CellScale manufactures biomaterial and mechanobiology test systems. Our mechanical test systems are specifically designed for biomaterials testing and incorporate temperature-controlled media baths, image capture and analysis software, and a range of gripping mechanisms. Our cell culture systems enable mechanically active environments in 2D or 3D. www.cellscale.com

Comecer is a world leader in protection technologies in the field of nuclear medicine, pharmaceutical isolation technology and nuclear power plant equipment. www.comecer.com

IEEE Engineering in Medicine and Biology Society (EMBS) is the world’s largest international society of biomedical engineers and provides access to the people, practices, information, ideas and opinions shaping one of the fastest growing fields focusing on the development and application of engineering concepts and methods to provide new solutions to biological, medical and healthcare problems. http://www.embs.org

eSpin Technologies, Inc.® will be exhibiting its nanofiber based biomedical product - Cytoweb® for tissue engineering. Available with a variety of options this nanofiber material is produced in clean rooms under cGMP compliant conditions. Cytoweb® provides repeatable characteristics that mimic 3D intracellular matrixes to enhance cellular growth. www.espintechnologies.com

Evonik is a global specialty chemicals company and leading supplier of bioresorbable polymers, amino acid derivatives, drug delivery technologies and API manufacturing to the Health Care industry. Our portfolio includes custom bioresorbable polymers for regenerative scaffolds and cell culture reagents that include amino and keto acids, peptides and customized products for media development. www.evonik.com

Flexcell specializes in products to apply mechanical load, (tension, compression, fluid shear), to cells in monolayer and 3D culture, specifically, equipment and consumables for creating environments to stretch monolayer cells and 3-D constructs. www.flexcellint.com

Fluidigm develops, manufactures, and markets life science systems based on integrated fluidic circuits (IFCs). This technology furthers research by minimizing costs and enhancing sensitivity for applications such as single-cell gene expression, high-throughput SNP genotyping, and next-generation sequencing. Single-cell gene expression profiling has recently emerged as a powerful method to uncover heterogeneity in cell populations. In response to this, Fluidigm has developed a streamlined and automated workflow for capturing and analyzing single cells. The new C1™ Single-Cell Auto Prep System isolates single cells starting with low cell number input. www.fluidigm.com

EXHIBITORS

Harvard Apparatus Regenerative Technologies is the leading supplier of bioreactors and control systems for the decellularization and cellularization of hollow and Solid Organs. THE ORCA (Organ Regeneration Control and Analysis) system offers unmatched flexibility and ease of use. Physiological parameters can be mimicked and all parameters recorded in real time. www.harvardapparatus.com

HypOxygen provides state of the art hypoxic workstations that lead the way in advancing research and innovation, while providing continued reliability for optimum results. We specialize in low oxygen workstations and incubator equipment for scientists focusing on cell research applications requiring precise atmospheric conditions that can be accurately controlled. www.hypoxygen.us

Instron® TGT instruments are uniquely designed for all aspects of tissue engineering & regenerative medicine. Test applications range from condition & engineer developing tissues to providing an in vitro testbed for drugs and cell therapy development. Instron TGT provides customers with comprehensive solutions for all their research, quality and testing requirements. www.instron.com

IOP Publishing is an international, not-for-profit, learned society publisher. We are a leader in scientific publishing and the electronic dissemination of peer-reviewed research. Visit booth #3 for a copy of Biomedical Materials and Biofabrication. http://www.iopscience.iop.org/bmm;www.iopscience.iop.org/bf

Kaneka Corp - Toward an Even More Impressive and Productive Future. Kaneka Corporation is a producer of chemical products including resins, pharmaceutical intermediaries, food supplements, synthetic fibers and fine chemicals. The Innovative Bone Marrow MSC Separation Device harvests mesenchymal stem cells (MSC) via a filter from bone marrow. http://kaneka-cellseparation.jp/msc/english; http://www.kaneka.co.jp/kaneka-e/

Do you need a source of pharmaceutical grade sodium hyaluronate for your TERM research? For over 25 years, our hyaluronan has improved the lives of more than 50 million patients. Please visit our booth and learn more or contact Rebecca at [email protected] or 952-368-6321. www.lifecore.com

The McGowan Institute for Regenerative Medicine is a partnership between University of Pittsburgh and UPMC. It serves as a base for researchers and clinicians working to advance the science of tissue engineering and biomaterials, cellular therapies, and medical devices. McGowan’s mission includes the development of innovative clinical protocols and the transfer of emerging technologies from “the bench to the bedside”. (www.mcgowan.pitt.edu)

Nitta Gelatin is one of the world’s leading suppliers of gelatin and collagen related products including beMatrix™ low-endotoxin gelatin. This high quality low-endotoxin gelatin has a variety of potential applications in the fields of regenerative medicine, medical devices and scientific research and is manufactured in a state-of-the-art biological clean room. http://nitta-gelatin.com/

NovaMatrix, a business unit of FMC BioPolymer, provides well-characterized, ultrapure alginate, peptide coupled alginate, water-soluble chitosan salts and sodium hyaluronate for use in tissue engineering, cell encapsulation, drug delivery and medical device applications. Our new NovaMatrix 3-D cell culture system expands research possibilities in regenerative medicine and drug discovery. http://www.novamatrix.biz/

Panasonic Healthcare Company is a global, leading provider of energy, environment, and lifestyle applications with laboratory equipment for pharmaceutical, life science and biotechnology applications. Product lines include space-efficient VIP® ultra-low temperature freezers, cryogenic freezers, pharmaceutical and medical refrigerators, cell culture incubators, plant growth chambers, and portable autoclaves. www.panasonic.com/biomedical

The Parker H. Petit Institute for Bioengineering and Bioscience (Petit Institute) has revolutionized the term “interdisciplinary research,” and has become an incubator for research teams to tackle complex medical research problems using an interdisciplinary approach. It has grown to include more than 140 faculty members from a wide variety of disciplines, which has played a vital role in the success of the Institute and its culture. From its eight “research neighborhoods” to the open atrium and even the building’s artwork, the Petit Institute was built from the ground up to foster an environment where innovative research emerges from the joint activities of bioengineering and bioscience faculty from more than nine different schools and departments. www.petitinstitute.gatech.edu

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EXHIBITORS

RoosterBio is focused on building a robust and sustainable Regenerative Medicine industry. Our products are affordable and standardized primary cells and media, manufactured and delivered with high quality and in formats that simplify product development efforts. RoosterBio products will accelerate the translation of cell therapy and tissue engineering technologies into the clinic. www.roosterbio.com

Tissue Source provides porcine tissue for tissue engineered medical devices, regenerative medicine technologies and biomedical research. Our QMS is ISO13485:2003 and 9001:2008 certified, ISO 22442-2:2007, FDA 21 CFR 820 and 589 compliant. The confidential customized processing and exceptional quality provided by Tissue Source are a foundation for exceptional medical products. www.tissue-source.com

Trevigen supplies Basement Membrane Extract (BME), laminin, fibronectin and vitronectin to enable undifferentiated stem cell growth. Laminin and BME used in high concentrations provide a suitable matrix to support differentiation of stem cells into organoid structures. Additionally we offer a wide range of extensively tested products for 3D culture needs. www.trevigen.com

VitaCyte manufactures and sells purified & defined tissue dissociation enzymes to isolate or recover cells from culture. Rigorous characterization of the purified enzymes using functional enzymatic assays improves lot to lot consistency, leading to a consistently manufactured, low endotoxin product. This manufacturing process minimizes the need for lot testing prior to use. www.vitacyte.com

The Wake Forest Institute for Regenerative Medicine’s mission is to improve patients’ lives through regenerative medicine therapies. Its scientists engineered the first laboratory-grown organs to be implanted into humans. The team currently is working to engineer more than 30 different organs and tissues and to develop cell therapies to restore organ function. http://www.wakehealth.edu/wfirm/

Organizer:

To accomplish its mission, the Society brings together the international community of persons engaged or interested in the field of tissue engineering and regenerative medicine and promotes education and research within the field of tissue engineering and regenerative medicine through regular meetings, publications and other forms of communication. The Society also serves as an international forum to promote the informed discussion of challenges and therapeutic benefits of the application of tissue engineering and regenerative medicine technologies. Most importantly, the Society is committed to bringing you closer to key professionals to support your mutual understanding of the field, accelerate your research in the field and to enable you to contribute to the ultimate care of patients in this very important way. To affect this interchange of information, the Society has endorsed the journal, Tissue Engineering, as its official publication and has negotiated a reduced subscription rate for members of the TERMIS. In addition, the TERMIS publishes a quarterly newsletter for its members to keep them abreast of developments in the field. The TERMIS World Congress Meeting will be held every three years. In the interim years the Continental Chapters will host annual meetings to promote tissue engineering and regenerative medicine research regionally. www.termis.org

PLATINUM CONFERENCE SPONSORS:

The Parker H. Petit Institute for Bioengineering and Bioscience (Petit Institute) has revolutionized the term “interdisciplinary research,” and has become an incubator for research teams to tackle complex medical research problems using an interdisciplinary approach. It has grown to include more than 140 faculty members from a wide variety of disciplines, which has played a vital role in the success of the Institute and its culture. From its eight “research neighborhoods” to the open atrium and even the building’s artwork, the Petit Institute was built from the ground up to foster an environment where innovative research emerges from the joint activities of bioengineering and bioscience faculty from more than nine different schools and departments. www.petitinstitute.gatech.edu

The Regenerative Engineering and Medicine (REM) research center is a joint collaboration between Emory University and Georgia Institute of Technology. REM is specifically focused on endogenous repair or how the body can harness its own potential to heal or regenerate. Bone, muscle, nerves, heart, blood vessels, and other tissues each have a baseline ability to regenerate. REM

investigators ask what can be done when trauma or disease in humans overwhelms the ability of tissues or organs to regenerate on their own. http://regenerativeengineeringandmedicine.com/

TERMIS-AM 2013 SPONSORS

Conference Sponsors:

The mission of the Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University is to shape and advance the discipline of biomedical engineering through innovative research and inspiring education, with the goal of comprehensive integration of engineering methods into the mainstream of health care. http://www.bme.gatech.edu

The Stem Cell Engineering Center (SCEC) was established in 2010 to foster the growth of the stem cell research community at Georgia Institute of Technology. The center’s mission is to cultivate collaborative relationships between the basic sciences along with investigators from various engineering disciplines to address key hurdles and technological challenges currently impeding the development of stem cell therapeutics and diagnostics. The Stem Cell Engineering Center provides core facilities and services to members of the center, such as access and training to work with human pluripotent stem cells and advanced cytometry equipment for phenotypic analyses, to facilitate investigators to better integrate the use of stem cells into their research programs. http://www.stemcellengineering.gatech.edu

The North American Veterinary Regenerative Medicine Association (NAVRMA) promotes the acquisition and distribution of knowledge regarding the emerging fields of regenerative medicine and stem cell therapy. These areas of medical research and their clinical applications are concerned with the regeneration of damaged tissues and organs and the development of new methods to help the body heal itself. http://www.navrma.org/

The National Science Foundation (NSF) is an independent federal agency created by Congress in 1950 “to promote the progress of science; to advance the national health, prosperity, and welfare; to secure the national defense”. NSF’s

goals--discovery, learning, research infrastructure and stewardship--provide an integrated strategy to advance the frontiers of knowledge, cultivate a world-class, broadly inclusive science and engineering workforce and expand the scientific literacy of all citizens, build the nation’s research capability through investments in advanced instrumentation and facilities, and support excellence in science and engineering research and education through a capable and responsive organization. www.nsf.gov

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Additional funding for this conference was made possible by 1 R13 EB 017617-01 from the National Institute of Biomedical Imaging and Bioengineering, the National Institute for Arthritis and Musculoskeletal and Skin Diseases, and the National Institute of Dental and Craniofacial Research. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Tissue Source provides porcine tissue for tissue engineered medical devices, regenerative medicine technologies and biomedical research. Our QMS is ISO13485:2003 and 9001:2008 certified, ISO 22442-2:2007, FDA 21 CFR 820 and 589 compliant. The confidential customized processing and exceptional quality provided by Tissue Source are a foundation for exceptional medical products. www.tissue-source.com

The Wake Forest Institute for Regenerative Medicine’s mission is to improve patients’ lives through regenerative medicine therapies. Its scientists engineered the first laboratory-grown organs to be implanted into humans. The team currently is working to engineer more than 30 different organs and tissues and to develop cell therapies to restore organ function. http://www.wakehealth.edu/wfirm/

Media sponsors:

Science Translational Medicine promotes human health by providing a forum for communicating the latest biomedical research findings from translational researchers in all areas of medicine. The journal strives to bridge the gap between the rich foundation of basic science and the needs of clinical medicine, facilitating information exchange in both directions. www.stm.sciencemag.org/

Cells Tissues Organs aims at bridging the gap between cell biology and developmental biology and the emerging fields of regenerative medicine (stem cell biology, tissue engineering, artificial organs, in vitro systems and transplantation biology). CTO offers a rapid and fair peer-review and exquisite reproduction quality. http://www.karger.com/cto

IOP Publishing is an international, not-for-profit, learned society publisher. We are a leader in scientific publishing and the electronic dissemination of peer-reviewed research. Visit booth #3 for a copy of Biomedical Materials and Biofabrication. http://www.iopscience.iop.org/bmm;www.iopscience.iop.org/bf

Tissue Engineering is the premier biomedical journal merging engineering and life sciences for tissue development. Part A provides fundamental research and understanding of structure-function relationships. Part B, Reviews publishes critical discussion and analyses to assess progression in the field. Part C Methods presents procedures and protocols to translate research into future clinical applications. www.liebertpub.com/products/product.aspx?pid=315

TERMIS-AM 2013 SPONSORS

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Documents

P ROGRAM - TERMISPoster Session I Monday, November 11 …. 25 - 32 Poster Session II Tuesday, November 12 …. 33 - 41 Student & Young Investigator Section Welcome & Activities …