Overview of IR-4 Biopesticide Research and Support Programir4.rutgers.edu/biopesticides/RWP/PowerPoint/Tue-B.Holm.pdf · Food Quality Protection Act (FQPA) Reduced Risk Strategy

Overview of IR-4 Biopesticide Research and Support Program

Presented to:

IR-4/EPA/PMRA/CA-DPR

Biopesticide Registration Workshop

November 13, 2001

Robert Holm, Ph.D.

Executive Director

IR-4 Milestones

! 1963

! 1975

! 1976

! 1977

! 1982

! 1989

Initiated by the Directors of State Agricultural Experiment Stations working with the U.S. Department of Agriculture-Cooperative States Research Service.

Regional Leader Laboratories- established to provide regional coordination and analytical services.

USDA-ARS established minor use program

Expanded to cover nursery and floral crops, forest seedlings,turfgrass, Christmas trees, and woody nursery stock

Expanded to cover registration of Biological Pest Control Agents

Established a GLP program

IR-4 Milestones

! 1993

! 1995

! 1997

! 2000

Initiated Quality Assurance Unit with SOP’s and GLP guidelines and training

Updated Strategic Plan to focus on • Reduced Risk Products and Biopesticides (dedicated research

funds)

Food Quality Protection Act (FQPA) Reduced Risk Strategy• Promote the registration of Reduced Risk products• Expand biopesticide programs

Revised Strategic Plan to focus on• Accelerate Reduced Risk chemistry registration• Gaining access to new chemistries and biopesticides

IR-4 Strategy

! Initiated in 1982! Focused mainly on support for registrants from 1982 - 1994 ! Designated funding for research projects since 1995

($1,795,000 in total) ! 1998 -14 Early Stage Projects for $300,000 ! 1999 -12 Early Stage Projects for $194,000

- 25 Advanced Stage Projects for $111,000 ! 2000 - 4 Early Stage Projects for $102,800

- 33 Advanced Stage Projects for $201,282

Biopesticide Program

IR-4 Strategy

! 2000 Biopesticide Workshop – co-sponsored by IR-4, PMRA and BPPA.

! 2001 - 1 Early Stage Project for $19,800

- 34 Advanced Stage Projects for $254,017

- 4 Food Use Workshop Biopesticide Projects for $20,183

- 4 Ornamental Workshop Biopesticide Projects for

$6,000 ! 2001 – Biopesticide Registration Workshop – planned for

November – co-sponsored by IR-4, BPPD and PMRA

Biopesticide Program

IR-4 Biopesticide Program

! Product" Bacillus thuringiensis (Bt)

" Gibberellic Acid (GA)

" Bacillus popilliae

" Methyl Eugenol (w/ Malathion)

" Grape Berry Moth Pheromone

" Codling Moth Granulosis Virus

" Pseudomonas fluorescens Strain NCIB 12089

" Lagenidium giganteum

! Crop(s)All (Label Expansions)

Strawberries & Blueberries

Pastures

All

Grape

Apple, Pear, Walnut & Plum

Mushroom

Rice

Success Stories # 1982-1994 Food Crop Clearances1

1 C.L. Hartman & G.L. Markle (1996) “IR-4 Program for Minor Crops” in Methods in Biotechnology. Vol. 5: Biopesticides Use and Delivery


! 1995" Methyl Anthranilate - bird repellent on blueberries, grapes and cherries" Codling Moth Granulosis Virus - apple, pear, walnut & plum" Cinnamaldehyde - mushrooms (Verticillium spot and dry bubble disease

control)

! 1996" Aspergillus flavus AF 36 - cotton-AZ only (aflatoxin control)-EUP" Trichoderma hamatum and Flavobacterium balustinum (TT and EUP) - on

vegetable bedding plants (damping-off and root rot control)

! 1997" Beauveria bassiana GSA - in CA greenhouse ornamentals (western flower

thrips control) (Efficacy Data)

Registration Success Stories


! 1998" Kaolin - insect control on 48 crops" Lysophosphatidylethanolamine (LPE) - EUP - promotion of ripening and extended

storage shelf life on 13 fruit crops" Pseudomonas fluorescens PRA 25 - EUP - seed treatment for soil borne diseases on

vegetables (peas, snapbeans, & sweet corn)

! 1999" Cinnamaldehyde - for insect and disease control on 53 crops" Formic Acid - for mite control in bee hives" (E)-11-Tetradecen-1-YL-Acetate Mating Disruption Phermone -for sparganothis

fruitworm in cranberry (Efficacy Data)" MCH (3-Methyl-2Cyclohex-1-One) Antiaggregation Phermone - for Douglas fir and

spruce beetle control (Efficacy Data)" Pseudomonas aureofaciens TX-1 - for pink snow mold control on turf (Efficacy Data)" Gibberellins - for PGR use on minor crops" Surround WP - new weather resistant kaolin formulation on fruit crops



! 2000" LPE - 97 and 98S formulations on 13 fruit crops (EUP) – promote ripening and

extend storage shelf life." Cinnamaldehyde – for mite/powdery mildew control on 39 crops." Chitosan (Elexa 4) – for powdery mildew control on grapes, roses and strawberries." Messenger (Harpin Protein) – for disease control on apples & grapes." Milsana – for powdery mildew control on ornamentals.

! 2001" Sucrose Fatty Acid Esters - on all commodities for insect and mite control (pending)" Macleaya Extract - for ornamental disease control (pending)


IR-4 Biopesticide Program2001 Funded Projects – Advanced Stage

Powdery Mildew/GrapesMilsana6 & Elexa8 BiofungicidesGrove/Washington St. Univ.

Codling Moth/PearsVirosoft7 BioinsecticideElkins & Van Steinwyk/UC Lake County

Insects/BlueberriesNature’s Glory9 BioinsecticideDrummond/Univ. of Maine

Foliar Diseases/OrnamentalsMilsana6 BiofungicideChase/Chase Gardens

Leaf Roller spp./ApplesIsomate5 pheromoneBrunner/Washington St. Univ.

Botrytis/Strawberry &Raspberry

Serenade1 BiofungicideBristow/Washington St. Univ.

Rhizoctonia, Pythium & Thielaviopsis/Flowers

Bl-9153, Prestop4, Mycostop4, & Subtilex4 Biofungicides

Benson/No. Carolina St. Univ.

Sclerotinia Blight/PeanutsContans2 BiofungicideBailey/No. Carolina St. Univ.

Botrytis (post-havest)/KiwiSerenade1 BiofungicideAdaskaveg/UC-Davis

Researcher/Organization Approach Target/Crop

1 AgraQuest 4 AgBio Development 7 BioTepp2 Encore Technologies 5 Pacific BioControl 8 Safe Science Inc.3 AgraSol, Inc. 6 KHH BioSci, Inc. 9 Ecoval, Inc.


Weeds/SteviaPelargonic Acid9 BioherbicideMorris & Haust/SuperSweetFarms, CA

Powdery Mildew/LettuceMilsana6, Elexa8 & Serenade1 BiofungicidesMatheron/Univ. of Arizona

Powdery Mildew/CantaloupeMilsana6, Elexa8 & Serenade1 BiofungicidesMatheron/Univ. of Arizona

Sclerotinia/LettuceContans2 & Serenade1 BiofungicidesMatheron/Univ. of Arizona

Botrytis/ChivesSerenade1 BiofungicideKoike/UC-Monterey County

Leaf Spot/PhotiniaAgBio-2224 BiofungicideHong & Banko/VPI & SU

Codling Moth & Oriental Fruit Moth/Apple

Isomate CM/OFM PheromonesGut/Michigan State Univ.

Powdery Mildew/GrapeMilsana6 and Elexa8 BiofungicidesGubler/UC-Davis

Powdery Mildew/Cucurbits & Strawberries

Milsana6 BiofungicideGubler/UC-Davis


2001 Funded Projects – Advanced Stage

1 AgraQuest 4 AgBio Development 7 Biotepp, Inc.2 Encore Technologies 5 Pacific BioControl 8 Safe Science Tech.3 AgraSol, Inc. 6 KHH BioSci, Inc. 9 Dow AgroSciences


Southern Pine Beetle/Southern Pine Stands

Verbenone13 PheromoneSalom/VPI & SUClark/USDA Forest Service

Douglas Fir Beetle/Douglas Fir

MCH12 Antiaggregation Pheromone13Ross/Oregon State Univ.

Seedling Diseases/Tomatoes & Bell Peppers

AtEze14 BiofungicideRoberts/Univ. of Florida

Tussock Moth/ConifersDouglass-Fir Tussock Moth Pheromone12Ragenovich/USDA Forest Service

Tarnished Plant Bug/Romaine Lettuce

Mycotrol 011 BioinsecticideParker, Skinner & Costa/Univ. of Vermont

Pythium/GeraniumAgBio 2224 BiofungicideNameth/Ohio State Univ.

Weeds/Snap Beans & Tomatoes

Nature’s Glory9 BioherbicideMullins/Univ. of Tennessee

Powdery Mildew/Cucumbers

Milsana6 BiofungicideMcGrath/Cornell University


4 AgBio Development 11 Emerald BioAg. Corp. 14 EcoSoils6 KHH Biosciences 12 Hercon Environmental.10 Ecoval Technologies 13 PheroTech Inc.



Postharvest Quality/Stone Fruit

Retain/AVG15 BiochemicalIR-4/Food Use Workshop

Powdery Mildew/GrapesMilsana6 & Elexa8 BiofungicidesWilcox/Cornell University

Powdery Mildew/Greenhouse Roses

Elexa8 BiofungicideWilliams/Brigham Young Univ.

Alternaria/Basil & CollardsSerenade1 BiofungicideValencia/Univ. of CA-Modesto

Annual Bluegrass/TurfXPO14 BioherbicideVargas/Michigan State Univ.

Dyer’s Woad/Range Land & US Forest Service

Dyer’s Woad Rust Bioherbicide*Thompson/Utah State Univ.

Insects/EggplantNature’s Glory10 InsecticideSorenson/No. Carolina State Univ.

Alternaria/PotatoAgBio 2224 BiofungicideSchwartz/Colorado State Univ.

Mummy Berry Disease/ Blueberry

Serenade1 BiofungicideScherm/Univ. of Georgia



1 AgraQuest 8 Safe Science 15 Valent Biosciences 4 AgBio Development 10 Ecoval Techonlogies * Early Stage Project- No6 KHH BioSci, Inc. 14 EcoSoils Commercial Company

IR-4 Biopesticide Program2000/2001 Products in Grants Program

BH"Pelargonic AcidDow AgroSciences

BI"Virosoft (codling moth granulosis virus)Biotepp

BF"Rootshield (Trichoderma harzianum)BioWorks, Inc

BF"BL915 (Pseudomonas fluorescens)Agra Sol, Inc.

BF"Serenade (Bacillus subtilis QST713)-AS & Organic FormulationAgraQuest

BF

BFBFBF

" Primastop/Prestop (Gliocladium catenulatum J1446)

" Subtilex (Bacillus subtilis MBI 600)" Mycostop G (Streptomyces griseoviridis K-61)" AgBio-222 (Dipotassium Phosphate/Phosphonate)

Ag Bio Development

Company Product Name(Active Ingredient)

Classification1

1 BF = Biofungicide BH = Bioherbicide B=BiochemicalBI = Bioinsecticide P = Pheromone


BF" AQ10 (Ampelomyces quisqualis)" Aspire (Candida oleophila I-182)

Ecogen

BF"eks Purge (Potassium Dihydrogen Phosphate)Lido

BF"Milsana (giant knotweed extract)KHH BioSci, Inc.

BIBIBFPGR

"BotaniGard (Beauvaria bassiana GHH)"Mycotrol (Beauvaria bassiana)"Valero (Cinnamite/ Cinnamaldehyde)"Auxigro ( Amino Butic Acid)

Emerald Bioagriculture

BH

BI

"Nature’s Glory Herbicide (Acetic/Ethanolic Acids)"Nature’s Glory Insecticide (Citric Acid)

Ecoval Tech., Inc.

BF

BH

"At-Eze (Pseudomonas chlororaphis)"XPO (Xanthomonas campestris P.V. Poannua)

EcoSoils

2000/2001 Products in Grants Program

γ


Classification1


IR-4 Biopesticide Program2000/2001 Products in Grants Program

BH" Eco-Clear (Chondrostereum purpureum)MycoLogic, Inc.

BI

B

"Dipel (Bacillus thuringiensis kurstaki)"Retain (Aminoethoxyvinylglycine)

Valent Biosciences

BIBFBF

"LQ215 (Natural Surfactant Blend)"Elexa 4 Plant Defense Booster (Chitosan)"CIT 30 (Citric Acid, Copper Sulfate & Zinc Citrate)

Safe Science

BI

P

"Verbonone Pouch"MCH Bubble Capsule

PheroTech, Inc.

P"Isomate (Mating Disruptant)Pacific BioControl


Classification1


2001 IR-4 Annual Meeting

! Active Ingredient" Trichoderma atroviride

" Aspergillus flavus AF 36

" Endochitinase Antifungal Proteins/Transgenic Plants

" Collectotrichum gleosporioides

" Sclerotinia species

" Sucrose Fatty Acid Esters

" Puccinia thlaspeos (Dyer’s Woad Rust)

! Classification1

BF

BF

BF

BH

BH

BI

BH

2000/2001 Products # Not Commercialized & without Trade Names


Biopesticide Companies

! 3M Canada2

! AgBio Development

! AgraQuest, Inc.2

! Ag Tech Corporation

! AgraSol, Inc.

! Apicure

! ARCADIS

! Arizona Cotton Res. & Protection Council

! AVA Chemical Ventures L.L.C.

! Becker Underwood

! Biologixs

! Biotepp, Inc.2

! BioWorks, Inc.2

! Bird Shield Repellent Corporation

! CAMAS Technologies

! Chemicals Laif

! Dow AgroSciences

! Ecogen2

! EcoSoils2

! Ecoval, Inc.

! Eden Bioscience Corp.2

! Emerald BioAgriculture2,3

Registrants IR-4 has worked with 1995-20011

1 Companies involved in the development and registration of biopesticides. Only current name is listed. Names of some biopesticide companies have changed because of mergers and acquisitions.

2 Member of Biopesticide Industry Alliance (BPIA)3 Formerly Auxein and Mycotech4 Formerly J.P. Regulators, Inc.5 Formerly Abbott Laboratories

Biopesticide Companies

! Encore Technologies, LLC2

! Engelhard

! Environmentally Safe Systems

! Growth Products

! Gustafson

! Hercon Environmental

! KALSEC

! KHH BioSci Inc.2

! Lido Chem Inc.

! Mann Lake Ltd.

! Mycologic Inc.

! Nutra-Park, Inc.2,4

! Pacific Biocontrol Limited

! PBT International

! Pherotech, Inc.2

! Plant Products Co. Ltd.

! Proguard Inc.

! Safe Science

! Sellew & Associates

! Taensa, Inc.2

! Thermo Trilogy2

! United Ag Products

! Valent BioSciences2,5

Registrants IR-4 has worked with 1995-20011

1 Companies involved in the development and registration of biopesticides. Only current name is listed. Names of some biopesticide companies have changed because of mergers and acquisitions.

2 Member of Biopesticide Industry Alliance (BPIA)3 Formerly Auxein and Mycotech4 Formerly J.P. Regulators, Inc.5 Formerly Abbott Laboratories

Documents

Overview of IR-4 Biopesticide Research and Support Programir4.rutgers.edu/biopesticides/RWP/PowerPoint/Tue-B.Holm.pdf · Food Quality Protection Act (FQPA) Reduced Risk Strategy