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Osteoporosis is an ancient disease
X-ray of Egyptian mummy,c. 5000 B.C. showing osteoporosis
With courtesy of Ghassan Maalouf
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But osteoporosis has only recentlybeen defined
"A disease characterized by low bone massand micro-architectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk."
WHO definition, 1994, the first time osteoporosis had a clinical definition
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Diagnosis of OsteoporosisT-score < -2.5
A new EBM project on risk assessment of Osteoporosis is almost finised
The role of IOF
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1998 1999 2000 2001 2002 2003 2004 2005
Members Locations
IOF members of CNS Committee of National Societies
172 members in 85 locations(November 2005)
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Membership status
76 members
33 members172 members
85 locations
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Key new global activities
Program area 1 Science
Program area 2 The IOF family
Program area 3 Promoting policy changes
Program area 4 Outreach and education
Program area 5 Administration and finance
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Programme Area 1
ScienceProjects:Socio economic projectsHealth economy modelQuality of life in EuropeQualeffoICAROS – EQ5D to fracture patients in Europe
Osteoporosis in Men- EU project NEMOOsteoporosis in ChildrenGeneticsVertebral fractures in Latin AmericaEU consulting panel- EU grantRequirement of resources in Europe
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Physician and healthcare workers trainingWHO project for GP
Regional cources
BMD training cources
Specific projects
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Evolution of World Osteoporosis DayThree year lifestyle campaign
2001Young people
2002Workplace
2003Quality of
life
2004 Osteo. in men
2007 Reduce your risk
Reduce your risk
DRAFT
2005 – ExerciseMove it or lose it
DRAFT
Bone appetit
2006 – FoodBone Appétit
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World Osteoporosis Day 2005“Move it or lose it”
3 posters
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IOF website
• Re-design
• Regional sites for Latin America and Middle East
• Society news
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WHO Health Academy• For Children• For Women• For Men• Health care workers
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Global burden of osteoporotic fractures
0.0
0.5
1.0
1.5
2.0
Africa
E MediterraneanSE Asia
Americas
W Pacific
Europe
World
DALYs (% NCD)
0.10
0.83
1.75
0.960.83
0.56
0.20
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Global burden of osteoporotic fractures
Europe
269
307
451
490
1048
1217
1236
1359
2734
2936
3088
3453
2006
0 1000 2000 3000 4000
BPH
Multiple sclerosis
Parkinson's
Peptic ulcer
RA
Hypertensive HD
Migraine
Asthma
Cirrhosis
Alzheimer’s
OA
COPD
IHD
Osteoporosis
DALY's (000)
15751
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Global burden of osteoporotic fractures
Skin
Cervix
Oesophagus
Bladder
Uterus
Ovary
Liver
Prostate
Oropharynx
Pancreas
Leukaemia
Lymphoma/ Myeloma
Stomach
Breast
Colorectum
Lung
Osteoporosis
266
392
428
438
454
501
532
541
582
705
712
733
1352
1703
1862
3244
2006
0 1000 2000 3000DALY's (000)
Europe
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Risk of having a hip fracture within the next year
0
2
4
6
8
10
12
14
16
18
Dementia Other psych. Anemia Diziness Diabetes Hypertension Other injuries Stroke Alkohol dis.
45-64 65-7475-8485-
RR
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% hip fracture within the next year for the following diagnoses, Age 45+
0
0,5
1
1,5
2
2,5
3
Dementia Other psych. Anemia Diziness Diabetes Hypertension Other injuries Stroke Alkohol dis.
Hip fractures%
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Risk of having a hip fracture, MI, Stroke within the next year if diagnosed dementia
0123456789
1011121314
Hipfracture MI Stroke
45-64 65-7475-8485-
RR
20Adapted from C.,Melton U. Osteoporosis Int. 2:285-289, 1992
Estimated number of hip fractures: (1000s)
1950 2050
600
3250
1950 2050
668
400
1950 2050
742
378
1950 205010
0
629
Total number ofhip fractures:
1950 = 1.66 million 2050 = 6.26 million
Hip fractureProjected worldwide increase
Projected to reach 3.250 million in Asia by 2050
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Suggestions
• Burden of disease- system-DALY?• Health economy- Quality of life.• Use detailed surveys in some countries-
risk factors- perceptions-satisfaction.• Attributable risk calculations based on
data
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This paper was produced for a meeting organized by Health & Consumer Protection DG and represents the views of its author on the subject. These views have not been adopted or in any way approved by the Commission and should not be relied upon as a statement of the Commission's or Health & Consumer Protection DG's views. The European Commission does not guarantee the accuracy of the data included in this paper, nor does it accept responsibility for any use made thereof.
