OPX Biotechnologies Inc.The Leading EDGE™

Renewable Chemical Business

Platt’s Renewable Chemicals Conference

Houston

12 September 2011

2OPXBIO Platt’s Renewable Chem Houston 12Sep11

Renewable BioAcrylic

3-HP BioAcrylic

$8 Billion Global Market Opportunity Direct replacement with 30-50% lower cost and equal performance

3OPXBIO Platt’s Renewable Chem Houston 12Sep11

Acrylic Acid Market

Existing $8 billion Growing Global Market

Customers demanding renewable acrylic

4OPXBIO Platt’s Renewable Chem Houston 12Sep11

Dow ChemicalStrategic Partner – BioAcrylic

• $50 billion annual revenue global chemical company

– Largest US producer of petro-acrylic and derivatives

– Committed bio-based strategy and investments

• BioAcrylic joint development agreement

– Joint funding and work to demonstrate BioAcrylic process

– Intent to jointly commercialize

Faster, Lower-Risk, Shared-Cost Development and Commercialization

Sugar Feedstock

Microbe & 3-HP

Bioprocess

BioAAConversion

Process

Commercial Production

Channel to Market

Dow JointOPXBIO Dow Dow

5OPXBIO Platt’s Renewable Chem Houston 12Sep11

2008 2009 2010 Q3 2010 Q3 2011 2012 2014

BioAcrylic Development PlanScale-Up and Commercialization

Comml Plant

750k L

100M Lbs/Yr

Demo Plant-2

50k L

1M Lbs/Yr

Demo Plant-1

3000L

60K Lbs/Yr

Lg Bench

10L

250 Lbs/YrSm Bench

1L

25 Lbs/YrShake Flask

100 ml

Lab Pilot Demo Commercial

Pilot

250L

5K Lbs/Yr

6OPXBIO Platt’s Renewable Chem Houston 12Sep11

Acrylic Product CostPetroAA vs BioAA Target

Acrylic Market Selling Price $1.20/lb

55% BioAcrylic

Cost Advantage

40% BioAcrylic

Cost Advantage

7OPXBIO Platt’s Renewable Chem Houston 12Sep11

Acrylic Product CostDextrose – Propylene Breakeven

BioAcrylic Cost Advantage

97% of Time Jan05 – Dec10

Current

Propylene

Price

BioAA

Commercial

Model Dextrose

Price

8OPXBIO Platt’s Renewable Chem Houston 12Sep11

Quantitative

Experimental

Design

Massively

Parallel

Genetic

Manipulations

Comprehensive &

High Resolution

Parallel

Processing

EDGE™ Technology PlatformEfficiency Directed Genome Engineering

9OPXBIO Platt’s Renewable Chem Houston 12Sep11

BioAcrylic Technology StatusPilot Scale Production Results

0

20

40

60

80

100

120

140

Rate Yield

ActualvsCommercialG

oal(%)

Jul09

Dec10

Commercial Rate & Yield Goals Achieved in 18 Months High Speed and Efficiency

Commercial

Goal

79%

2.6 g/L/hr

70g/L titer

in

26 hours

10OPXBIO Platt’s Renewable Chem Houston 12Sep11

BioAcrylic Product Cost Pilot Process Results, Commercial Plant Model

Achieved Commercial Goal in Only 18 Months High Speed and Efficiency

$17.82

$8.76

$3.03

$1.43

$7.61

$1.06 $.70

Assuming $.14/lb Dextrose Feedstock

Equivalent to $.54/lb Cost from

$.08/lb Sucrose in

Brazil

11OPXBIO Platt’s Renewable Chem Houston 12Sep11

Market OpportunitiesLeveraging BioAcrylic Success

3-HP BioAcrylic

1,3 Propanediol

Acrylamide

Acrylonitrile

Acetonitrile

Propriolactone

Malonic Acid

Sugar or

CO2 + H2

Fatty Acid Esters

Alkyl Alcohols

Bio/Diesel

1,4 BDO

Succinic Acid

Propanediol

$8B

>$30B>$500B

12OPXBIO Platt’s Renewable Chem Houston 12Sep11

Fatty Acids2nd Product in Early Development

• Bioprocess for CO2 and H2 fermentation to fatty acids

– Confirms versatility of EDGE™ technology platform

– Low cost feedstock for chemicals and fuels

– CO2 and H2 from gasified biomass or solid waste, natural gas

• Lab scale production of fatty acids demonstrated

• Chemical application in consumer and industrial products

– $5B market opportunity

• Also used to make renewable diesel and jet fuel

– Supported by $6M award from the US Dept. of Energy

– Collaborating with NREL and Johnson-Matthey

– Jet fuel from fatty acids demonstrated in lab scale engine

– >$500B market opportunity

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