©2019 Novocure. All rights reserved. Optune, nCompass, and Novocure are trademarks of Novocure. US-OPT-02421

The MRI results of my brain, … showed a mass about the size of a golf ball just behind my left eye. A tumor, they told me. Okay, well, what’s gonna happen to me? They mentioned something about “a large tumor,” but I informed them, unless I was going to die tomorrow, I had work to finish and a whole group of people dependent on it. Two days later, after the release (because there was not an earlier flight), I was on a flight home, having promised to follow up with our family doctor.

Four days later, after an appointment with a neurosurgeon and additional MRIs, I underwent surgery to remove what we could of the tumor. It’s while I was recovering that my diagnosis of glioblastoma was confirmed.

Once I recovered from surgery, I started my six weeks with chemotherapy and radiation—and I had, and still have, MRIs every two months to keep track of the cancer’s activity.

“What’s gonna happen to me?”

I grew up in Alaska. My siblings and I spent most of our time looking for ways to entertain ourselves ... or hiding from Dad, who always had some kind of work for us to do. Repairing and making stuff himself was a way of life for him.

The thing about woodworking, … is that [it requires] an incredible amount of resourcefulness, problem-solving, and attention to detail. You sort of have to figure things out as you go, no matter how daunting. The same can be said about living with glioblastoma.

I was on a business trip one weekend, out walking around and thinking about how important this software release I was working on was going to be. Next thing I knew, I was coming to, flat on my back with my feet on the sidewalk, my upper body in the street, and lots of people talking above me, saying stuff I couldn’t follow. Then, it was a whole bunch of ER doctors saying stuff above me that I really couldn’t follow.

Meet Brian, an Optune user

Meeting the Optune CommunityFind out about different ways you can connect with Optune users.

Optune User’s ColumnLong-time users give personal answers to frequently asked questions about life with Optune.

Planning a Summer Vacation?nCompass™ can provide the support you need to travel with Optune.

What’s inside

Marcia is an Optune user. BT is her husband and caregiver.

Optune® Community Newsletter Made by Optune users for people with GBM.

After chemotherapy and radiation, Taylor’s radiation oncologist introduced him to Optune. He was very interested in Optune because, he felt

Buddy Program Ambassador Spotlight: Taylor, Optune User

Taylor was diagnosed with glioblastoma at the age of 31. After having worsening headaches over the course of a week, his wife took him to the ER where they did a CT scan. Unfortunately, the scan showed a large mass behind Taylor’s left eye.

Taylor had surgery, where his neurosurgeon was able to get 90% of the tumor out. Several weeks later, he was officially diagnosed with a grade 4 glioblastoma.

Meeting the Optune Community

Optune Open Houses are live educational events where you can:• Learn more about GBM and Optune• Hear firsthand from Optune users and caregivers about starting

and incorporating Optune into daily life

The Optune Buddy Program connects you with users and/or caregivers who want to share what they’ve learned with you.*

Some things you can talk to a current user or caregiver about include:• Personal experiences with GBM and Optune• How they incorporated Optune into their daily lives• Navigating challenges and finding support

“ this was a way to keep fighting the cancer. If we were fighting, we had reason to hope. What more can you ask for when you’re given a life sentence?”

* Please note that an Optune user or caregiver cannot provide you with medical advice because each person is different. Consult with your doctor for medically related questions.

Visit Optune.com to find out more

Laura is an Optune user.

Discover more at Optune.com

What is Optune® approved to treat?

Optune is a wearable, portable, FDA-approved device indicated to treat a type of brain cancer called glioblastoma multiforme (GBM) in adult patients 22 years of age or older.

Newly diagnosed GBMIf you have newly diagnosed GBM, Optune is used together with a chemotherapy called temozolomide (TMZ) if:

• Your cancer is confirmed by your healthcare professional AND• You have had surgery to remove as much of the tumor as possible

Recurrent GBMIf your tumor has come back, Optune can be used alone as an alternative to standard medical therapy if:

• You have tried surgery and radiation and they did not work or are no longer working AND• You have tried chemotherapy and your GBM has been confirmed by your healthcare professional

Who should not use Optune?

Optune is not for everyone. Talk to your doctor if you have:

• An implanted medical device (programmable shunt), skull defect (missing bone with no replacement), or bullet fragment. Optune has not been tested in people with implanted electronic devices, which may cause the devices not to work properly, and Optune has not been tested in people with skull defects or bullet fragments, which may cause Optune not to work properly

• A known sensitivity to conductive hydrogels (the gel on the arrays placed on the scalp like the ones used on EKGs). When Optune comes into contact with the skin, it may cause more redness and itching or may rarely cause a life-threatening allergic reaction

Do not use Optune if you are pregnant or are planning to become pregnant. It is not known if Optune is safe or effective during pregnancy.

What should I know before using Optune?

Optune should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure®, the maker of Optune.

• Do not use any parts that did not come with the Optune Treatment Kit sent to you by Novocure or given to you by your doctor

• Do not get the device or transducer arrays wet

• If you have an underlying serious skin condition on the scalp, discuss with your doctor whether this may prevent or temporarily interfere with Optune treatment

What are the possible side effects of Optune?

Most common side effects of Optune when used together with chemotherapy (temozolomide, or TMZ) were low blood platelet count, nausea, constipation, vomiting, tiredness, scalp irritation from the device, headache, seizure, and depression.

The most common side effects when using Optune alone were scalp irritation (redness and itchiness) and headache. Other side effects were malaise, muscle twitching, fall and skin ulcers.

Talk to your doctor if you have any of these side effects or questions.

Please visit Optune.com/Safety for the Optune Patient Information and Operation Manual and complete information regarding the device’s indications, contraindications, warnings, and precautions.

Patient images reflect the health status of the patients at the time each photo was taken.

Brian is an Optune user. Susan is his wife and caregiver.

1-855-281-9301

support@novocure.com

Brian is an Optune user.

Jeanneane is an Optune User.

Travel FAQsAnswered by Optune Users and Caregivers

Have you taken a vacation with Optune? Have you flown?

Jeanneane: My mom lives in West Virginia so I fly a fair amount to go visit her. I’ve also gone on a few other flights within the U.S. and will soon be flying to Alaska to take a cruise!

Andrea: [Darrell and I] vacation every month. We have taken some car trips, many train trips (we love the sleeper cars), and a few domestic air flight trips. We have not yet flown internationally. Once each of our travels was initiated, Optune was never a problem.

I can also tell you I’m still feeling positive. It’s really hard knowing what this disease can do, but the worst part is watching my family suffer. So, I have decided to make my time here as positive as possible so that those around me can feed off that energy. When I look at the infant crib I crafted for my granddaughter when she was born, I can see each individual piece. I can remember standing at my workbench in the basement of our house, with all the parts and tools laid out in front of me. With my best-laid plans, I got to work. And finally, I can remember the look on my daughter’s face when I presented the crib to her. Small, meaningful moments like this make my life what it is—and they make my life worth living.

“ Small, meaningful moments like this make my life what it is—and they make my life worth living.”

What techniques or suggestions do you have regarding travel with Optune?

Jeanneane: My experiences flying taught me that most airlines have a policy where medical equipment is not counted toward your carry-on allowance. I can just show the letter that nCompass provides which explains that Optune is a medical device. Andrea:

Darrell sees no benefit to powering down and going through the x-ray machines at the airport’s security check, because personnel must still wand him down (in our understanding). So, he always requests a full pat down. It takes about 15 minutes.

Available to support you before and during your travel!

Planning a Summer Vacation?Optune® User’s Column

Meet Brian, continuedFor the first time in a long time, I wasn’t thinking about how I was going to move up in the world. I was thinking about how I wanted to leave the world in better shape for my family. I returned to work with my doctor’s “okay” to bring in as much money as I could, while I could. I was consistently working full days. Life seemed almost normal!

[At] an appointment with my radiation oncologist, he asked me if I’d be interested in trying a medical device called Optune for the treatment of GBM and walked through the risks and benefits with me. I considered it as an opportunity to hopefully extend whatever time I had left. They couldn’t say Optune was the solution, but I think I’ve always had the same attitude when it comes to treatment: I have nothing to lose and everything to gain.

Knowing that the monthly usage target for wearing Optune should be 18 hours per day, my main concern was how I would continue traveling for work while maximizing my time on Optune. I cleared this with my doctor and I learned that, luckily, Novocure will work with me to ship my supplies to my hotel—even on short notice.

Occasionally, I have skin irritation from the arrays, and I have bought a cooling pillow and a fan to keep my head cool, especially during the summer months. I make sure to talk to my doctor about any side effects I experience on treatment.

I am still working full-time at a desk job and maintain some of my hobbies, like woodworking. So far, it’s been awesome.

Dear Optune User,

I love to travel. How easy is it to continue with treatment while on the go?

I also love to travel. And with nCompass there to support me, I have had no trouble staying on Optune and on the go. In fact, I once planned an extended camping trip and, with the help of my DSS, was able to get extra sets of batteries to take with me.

Because of that, I was able to enjoy my trip without worrying about losing time on Optune.

It was a relief to know that I could continue fighting GBM, even while disconnecting in the great outdoors.

Eric

Dear Optune User,

How do you stay cool wearing Optune during hot weather?

Some warming sensation can be expected while using Optune, which can be uncomfortable during warm weather months.

While most people get used to this quickly, I have found that a cooling pillow helps me sleep with Optune on.

And, when I am out in the heat, I am able to stay cool with a solar-powered, fan-equipped hat that I made myself.

But, remember, if you notice any change in your health, including being especially uncomfortable or experiencing a rash, sores, or skin ulcers on your scalp, please contact your doctor immediately.

Taylor

Contact nCompass for 24/7 personalized support by phone or email

Darrell is an Optune User. Andrea is his wife and caregiver.

1-855-281-9301

support@novocure.com

Brian is an Optune user.

Jeanneane isan Optune User.

Travel FAQsAnswered by Optune Users and Caregivers

Have you taken a vacationwith Optune?Have you flown?

Jeanneane:My mom lives in West Virginia so I fly a fair amount to go visit her. I’ve also gone on a few other flights within the U.S. and will soon be flying to Alaska to take a cruise!

Andrea:[Darrell and I] vacation every month. We have taken some car trips, many train trips (we love the sleeper cars), and a few domestic air flight trips. We have not yet flown internationally. Once each of our travels was initiated, Optune was never a problem.

I can also tell you I’m still feeling positive. It’s really hard knowing what this disease can do, but the worst part is watching my family suffer. So, I have decided to make my time here as positive as possible so that those around me can feed off that energy.

When I look at the infant crib I crafted for my granddaughterwhen she was born, I can see each individual piece. I can remember standing at my workbench in the basement of our house, with all the parts and tools laid out in front of me. With my best-laid plans, I got to work. And finally, I can remember the look on my daughter’s face when I presented the crib to her. Small, meaningful moments like this make my life what it is—and they make my life worth living.

“ Small, meaningful moments like this make my life what it is—and they make my life worth living.”

What techniques orsuggestions do you haveregarding travel withOptune?

Jeanneane: My experiences flying taught me that most airlines have a policy where medical equipment is not counted toward your carry-on allowance. I can just show the letter that nCompass provides which explains that Optune is a medical device. Andrea:

Darrell sees no benefit to powering down and going through the x-ray machines at theairport’s security check, because personnel must still wand him down (in our understanding). So, he always requests a full pat down. It takes about 15 minutes.

Available to support you before and during your travel!

Planning a Summer Vacation?Optune® User’s Column

Meet Brian, continuedFor the first time in a long time, I wasn’t thinking about how I was going to move up in the world. I was thinking about how I wanted to leave the world in better shape for my family. I returned to work with my doctor’s “okay” to bring in as much money as I could, while I could. I was consistently working full days. Life seemed almost normal!

[At] an appointment with my radiation oncologist, he asked me if I’d be interested in trying a medical device called Optune for the treatment of GBM and walked through the risks and benefits with me. I consideredit as an opportunity to hopefully extend whatever time I had left. Theycouldn’t say Optune was the solution, but I think I’ve always had the same attitude when it comes to treatment: I have nothing to lose and everything to gain.

Knowing that the monthly usage target for wearing Optune should be 18 hours per day, my main concern was how I would continue traveling for work while maximizing my time on Optune. I cleared this with my doctor and I learned that, luckily, Novocure will work with me to ship my supplies to my hotel—even on short notice.

Occasionally, I have skin irritation from the arrays, and I have bought a cooling pillow and a fan to keep my head cool, especially during the summer months. I make sure to talk to my doctor about any side effects I experience on treatment.

I am still working full-time at a desk job and maintain some of my hobbies, like woodworking. So far, it’s been awesome.

Dear Optune User,

I love to travel. How easy is it to continue with treatment while on the go?

I also love to travel. And with nCompass there to support me, I have had no trouble staying on Optune and on the go. In fact, I once planned an extended camping trip and, with the help of my DSS, was able to get extra sets of batteries to take with me.

Because of that, I was able to enjoy my trip without worrying about losing time on Optune.

It was a relief to know that I could continue fighting GBM, evenwhile disconnecting in the great outdoors.

Eric

Dear Optune User,

How do you stay cool wearingOptune during hot weather?

Some warming sensation can be expected while using Optune, which can be uncomfortable during warm weather months.

While most people get used to this quickly, I have found that a cooling pillow helps me sleep with Optune on.

And, when I am out in the heat, I am able to stay cool with a solar-powered, fan-equipped hat that I made myself.

But, remember, if you notice any change in your health, including being especially uncomfortable or experiencing a rash, sores, or skin ulcers on your scalp, please contact your doctor immediately.

Taylor

Contact nCompass for 24/7 personalized support by phone or email

Darrell is an Optune User.Andrea is his wifeand caregiver.

©2019 Novocure. All rights reserved. Optune, nCompass, and Novocure are trademarks of Novocure. US-OPT-02421

The MRI results of my brain, … showed a mass about the size of a golf ball just behind my left eye. A tumor, they told me. Okay, well, what’s gonna happen to me? They mentioned something about “a large tumor,” but I informed them, unless I was going to die tomorrow, I had work to finish and a whole group of people dependent on it. Two days later, after the release (because there was not an earlier flight), I was on a flight home, having promised to follow up with our family doctor.

Four days later, after an appointment with a neurosurgeonand additional MRIs, I underwent surgery to remove what we could of the tumor. It’s while I was recovering that my diagnosis of glioblastoma was confirmed.

Once I recovered from surgery, I started my six weeks with chemotherapy and radiation—and I had, and still have, MRIs every two months to keep track of the cancer’s activity.

“What’s gonnahappen to me?”

I grew up in Alaska. My siblings and I spent most of our time looking for ways to entertain ourselves ... or hiding from Dad, who always had some kind of work for us to do. Repairing and making stuff himself was a way of life for him.

The thing about woodworking, … is that [it requires] an incredible amount of resourcefulness, problem-solving, and attention to detail. You sort of have to figure things out as you go, no matter how daunting. The same can be said about living with glioblastoma.

I was on a business trip one weekend, out walking around and thinking about howimportant this software releaseI was working on was goingto be. Next thing I knew, I wascoming to, flat on my back withmy feet on the sidewalk, myupper body in the street, andlots of people talking above me,saying stuff I couldn’t follow.Then, it was a whole bunch ofER doctors saying stuff aboveme that I really couldn’t follow.

Meet Brian, an Optune user

Meeting the Optune CommunityFind out about different ways you can connect with Optune users.

OptuneUser’s ColumnLong-time users give personal answers to frequently asked questionsabout life with Optune.

Planning aSummer Vacation?nCompass™ can provide the support you need to travel with Optune.

What’s inside

Marcia is an Optune user.BT is her husband and caregiver.

Optune® CommunityNewsletterMade by Optune users for people with GBM.

After chemotherapy and radiation, Taylor’s radiation oncologist introduced him to Optune. He was very interestedin Optune because, he felt

Buddy Program Ambassador Spotlight: Taylor, Optune User

Taylor was diagnosed with glioblastoma at the age of 31. After having worsening headaches over the course of a week, his wife took him to the ER where they did a CT scan. Unfortunately, the scan showed a large mass behind Taylor’s left eye.

Taylor had surgery, where his neurosurgeon was able to get 90% of the tumor out. Several weeks later, he was officially diagnosed with a grade 4 glioblastoma.

Meeting the Optune Community

Optune Open Houses are live educational events where you can:• Learn more about GBM and Optune• Hear firsthand from Optune users and caregivers about starting

and incorporating Optune into daily life

The Optune Buddy Program connects you with users and/or caregivers who want to share what they’ve learned with you.*

Some things you can talk to a current user or caregiver about include:• Personal experiences with GBM and Optune• How they incorporated Optune into their daily lives• Navigating challenges and finding support

“ this was a way to keep fighting the cancer. If we were fighting, we had reason to hope. What more can you ask for when you’re given a life sentence?”

* Please note that an Optune useror caregiver cannot provide youwith medical advice becauseeach person is different.Consult with your doctor for medically related questions.

Visit Optune.com to find out more

Laura is an Optune user.

Discover more at Optune.com

What is Optune® approved to treat?

Optune is a wearable, portable, FDA-approved device indicated to treat a type of brain cancer called glioblastoma multiforme (GBM) in adult patients 22 years of age or older.

Newly diagnosed GBMIf you have newly diagnosed GBM, Optune is used together with a chemotherapy called temozolomide (TMZ) if:

• Your cancer is confirmed by your healthcare professional AND• You have had surgery to remove as much of the tumor as possible

Recurrent GBMIf your tumor has come back, Optune can be used alone as an alternative to standard medical therapy if:

• You have tried surgery and radiation and they did not work or are no longer working AND• You have tried chemotherapy and your GBM has been confirmed by your healthcare professional

Who should not use Optune?

Optune is not for everyone. Talk to your doctor if you have:

• An implanted medical device (programmable shunt), skull defect (missing bone with no replacement), or bullet fragment. Optune has not been tested in people with implanted electronic devices, which may cause the devices not to work properly, and Optune has not been tested in people with skull defects or bullet fragments, which may cause Optune not to work properly

• A known sensitivity to conductive hydrogels (the gel on the arrays placed on the scalp like the ones used on EKGs). When Optune comes into contact with the skin, it may cause more redness and itching or may rarely cause a life-threatening allergic reaction

Do not use Optune if you are pregnant or are planning to become pregnant. It is not known if Optune is safe or effective during pregnancy.

What should I know before using Optune?

Optune should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure®, the maker of Optune.

• Do not use any parts that did not come with the Optune Treatment Kit sent to you by Novocure or given to you by your doctor

• Do not get the device or transducer arrays wet

• If you have an underlying serious skin condition on the scalp, discuss with your doctor whether this may prevent or temporarily interfere with Optune treatment

What are the possible side effects of Optune?

Most common side effects of Optune when used together with chemotherapy (temozolomide, or TMZ) were low blood platelet count, nausea, constipation, vomiting, tiredness, scalp irritation from the device, headache, seizure, and depression.

The most common side effects when using Optune alone were scalp irritation (redness and itchiness) and headache. Other side effects were malaise, muscle twitching, fall and skin ulcers.

Talk to your doctor if you have any of these side effects or questions.

Please visit Optune.com/Safety for the Optune Patient Information and Operation Manual and complete information regarding the device’s indications, contraindications, warnings, and precautions.

Patient images reflect the health status of the patients at the time each photo was taken.

Brian is an Optune user.Susan is his wife and caregiver.

1-855-281-9301

support@novocure.com

Brian is an Optune user.

Jeanneane is an Optune User.

Travel FAQsAnswered by Optune Users and Caregivers

Have you taken a vacation with Optune? Have you flown?

Jeanneane: My mom lives in West Virginia so I fly a fair amount to go visit her. I’ve also gone on a few other flights within the U.S. and will soon be flying to Alaska to take a cruise!

Andrea: [Darrell and I] vacation every month. We have taken some car trips, many train trips (we love the sleeper cars), and a few domestic air flight trips. We have not yet flown internationally. Once each of our travels was initiated, Optune was never a problem.

I can also tell you I’m still feeling positive. It’s really hard knowing what this disease can do, but the worst part is watching my family suffer. So, I have decided to make my time here as positive as possible so that those around me can feed off that energy. When I look at the infant crib I crafted for my granddaughter when she was born, I can see each individual piece. I can remember standing at my workbench in the basement of our house, with all the parts and tools laid out in front of me. With my best-laid plans, I got to work. And finally, I can remember the look on my daughter’s face when I presented the crib to her. Small, meaningful moments like this make my life what it is—and they make my life worth living.

“ Small, meaningful moments like this make my life what it is—and they make my life worth living.”

What techniques or suggestions do you have regarding travel with Optune?

Jeanneane: My experiences flying taught me that most airlines have a policy where medical equipment is not counted toward your carry-on allowance. I can just show the letter that nCompass provides which explains that Optune is a medical device. Andrea:

Darrell sees no benefit to powering down and going through the x-ray machines at the airport’s security check, because personnel must still wand him down (in our understanding). So, he always requests a full pat down. It takes about 15 minutes.

Available to support you before and during your travel!

Planning a Summer Vacation?Optune® User’s Column

Meet Brian, continuedFor the first time in a long time, I wasn’t thinking about how I was going to move up in the world. I was thinking about how I wanted to leave the world in better shape for my family. I returned to work with my doctor’s “okay” to bring in as much money as I could, while I could. I was consistently working full days. Life seemed almost normal!

[At] an appointment with my radiation oncologist, he asked me if I’d be interested in trying a medical device called Optune for the treatment of GBM and walked through the risks and benefits with me. I considered it as an opportunity to hopefully extend whatever time I had left. They couldn’t say Optune was the solution, but I think I’ve always had the same attitude when it comes to treatment: I have nothing to lose and everything to gain.

Knowing that the monthly usage target for wearing Optune should be 18 hours per day, my main concern was how I would continue traveling for work while maximizing my time on Optune. I cleared this with my doctor and I learned that, luckily, Novocure will work with me to ship my supplies to my hotel—even on short notice.

Occasionally, I have skin irritation from the arrays, and I have bought a cooling pillow and a fan to keep my head cool, especially during the summer months. I make sure to talk to my doctor about any side effects I experience on treatment.

I am still working full-time at a desk job and maintain some of my hobbies, like woodworking. So far, it’s been awesome.

Dear Optune User,

I love to travel. How easy is it to continue with treatment while on the go?

I also love to travel. And with nCompass there to support me, I have had no trouble staying on Optune and on the go. In fact, I once planned an extended camping trip and, with the help of my DSS, was able to get extra sets of batteries to take with me.

Because of that, I was able to enjoy my trip without worrying about losing time on Optune.

It was a relief to know that I could continue fighting GBM, even while disconnecting in the great outdoors.

Eric

Dear Optune User,

How do you stay cool wearing Optune during hot weather?

Some warming sensation can be expected while using Optune, which can be uncomfortable during warm weather months.

While most people get used to this quickly, I have found that a cooling pillow helps me sleep with Optune on.

And, when I am out in the heat, I am able to stay cool with a solar-powered, fan-equipped hat that I made myself.

But, remember, if you notice any change in your health, including being especially uncomfortable or experiencing a rash, sores, or skin ulcers on your scalp, please contact your doctor immediately.

Taylor

Contact nCompass for 24/7 personalized support by phone or email

Darrell is an Optune User. Andrea is his wife and caregiver.

1-855-281-9301

support@novocure.com

Brian is an Optune user.

Jeanneane is an Optune User.

Travel FAQsAnswered by Optune Users and Caregivers

Have you taken a vacation with Optune? Have you flown?

Jeanneane: My mom lives in West Virginia so I fly a fair amount to go visit her. I’ve also gone on a few other flights within the U.S. and will soon be flying to Alaska to take a cruise!

Andrea: [Darrell and I] vacation every month. We have taken some car trips, many train trips (we love the sleeper cars), and a few domestic air flight trips. We have not yet flown internationally. Once each of our travels was initiated, Optune was never a problem.

I can also tell you I’m still feeling positive. It’s really hard knowing what this disease can do, but the worst part is watching my family suffer. So, I have decided to make my time here as positive as possible so that those around me can feed off that energy. When I look at the infant crib I crafted for my granddaughter when she was born, I can see each individual piece. I can remember standing at my workbench in the basement of our house, with all the parts and tools laid out in front of me. With my best-laid plans, I got to work. And finally, I can remember the look on my daughter’s face when I presented the crib to her. Small, meaningful moments like this make my life what it is—and they make my life worth living.

“ Small, meaningful moments like this make my life what it is—and they make my life worth living.”

What techniques or suggestions do you have regarding travel with Optune?

Jeanneane: My experiences flying taught me that most airlines have a policy where medical equipment is not counted toward your carry-on allowance. I can just show the letter that nCompass provides which explains that Optune is a medical device. Andrea:

Darrell sees no benefit to powering down and going through the x-ray machines at the airport’s security check, because personnel must still wand him down (in our understanding). So, he always requests a full pat down. It takes about 15 minutes.

Available to support you before and during your travel!

Planning a Summer Vacation?Optune® User’s Column

Meet Brian, continuedFor the first time in a long time, I wasn’t thinking about how I was going to move up in the world. I was thinking about how I wanted to leave the world in better shape for my family. I returned to work with my doctor’s “okay” to bring in as much money as I could, while I could. I was consistently working full days. Life seemed almost normal!

[At] an appointment with my radiation oncologist, he asked me if I’d be interested in trying a medical device called Optune for the treatment of GBM and walked through the risks and benefits with me. I considered it as an opportunity to hopefully extend whatever time I had left. They couldn’t say Optune was the solution, but I think I’ve always had the same attitude when it comes to treatment: I have nothing to lose and everything to gain.

Knowing that the monthly usage target for wearing Optune should be 18 hours per day, my main concern was how I would continue traveling for work while maximizing my time on Optune. I cleared this with my doctor and I learned that, luckily, Novocure will work with me to ship my supplies to my hotel—even on short notice.

Occasionally, I have skin irritation from the arrays, and I have bought a cooling pillow and a fan to keep my head cool, especially during the summer months. I make sure to talk to my doctor about any side effects I experience on treatment.

I am still working full-time at a desk job and maintain some of my hobbies, like woodworking. So far, it’s been awesome.

Dear Optune User,

I love to travel. How easy is it to continue with treatment while on the go?

I also love to travel. And with nCompass there to support me, I have had no trouble staying on Optune and on the go. In fact, I once planned an extended camping trip and, with the help of my DSS, was able to get extra sets of batteries to take with me.

Because of that, I was able to enjoy my trip without worrying about losing time on Optune.

It was a relief to know that I could continue fighting GBM, even while disconnecting in the great outdoors.

Eric

Dear Optune User,

How do you stay cool wearing Optune during hot weather?

Some warming sensation can be expected while using Optune, which can be uncomfortable during warm weather months.

While most people get used to this quickly, I have found that a cooling pillow helps me sleep with Optune on.

And, when I am out in the heat, I am able to stay cool with a solar-powered, fan-equipped hat that I made myself.

But, remember, if you notice any change in your health, including being especially uncomfortable or experiencing a rash, sores, or skin ulcers on your scalp, please contact your doctor immediately.

Taylor

Contact nCompass for 24/7 personalized support by phone or email

Darrell is an Optune User. Andrea is his wife and caregiver.

1-855-281-9301

support@novocure.com

Brian is an Optune user.

Jeanneane is an Optune User.

Travel FAQsAnswered by Optune Users and Caregivers

Have you taken a vacation with Optune? Have you flown?

Jeanneane: My mom lives in West Virginia so I fly a fair amount to go visit her. I’ve also gone on a few other flights within the U.S. and will soon be flying to Alaska to take a cruise!

Andrea: [Darrell and I] vacation every month. We have taken some car trips, many train trips (we love the sleeper cars), and a few domestic air flight trips. We have not yet flown internationally. Once each of our travels was initiated, Optune was never a problem.

I can also tell you I’m still feeling positive. It’s really hard knowing what this disease can do, but the worst part is watching my family suffer. So, I have decided to make my time here as positive as possible so that those around me can feed off that energy. When I look at the infant crib I crafted for my granddaughter when she was born, I can see each individual piece. I can remember standing at my workbench in the basement of our house, with all the parts and tools laid out in front of me. With my best-laid plans, I got to work. And finally, I can remember the look on my daughter’s face when I presented the crib to her. Small, meaningful moments like this make my life what it is—and they make my life worth living.

“ Small, meaningful moments like this make my life what it is—and they make my life worth living.”

What techniques or suggestions do you have regarding travel with Optune?

Jeanneane: My experiences flying taught me that most airlines have a policy where medical equipment is not counted toward your carry-on allowance. I can just show the letter that nCompass provides which explains that Optune is a medical device. Andrea:

Darrell sees no benefit to powering down and going through the x-ray machines at the airport’s security check, because personnel must still wand him down (in our understanding). So, he always requests a full pat down. It takes about 15 minutes.

Available to support you before and during your travel!

Planning a Summer Vacation?Optune® User’s Column

Meet Brian, continuedFor the first time in a long time, I wasn’t thinking about how I was going to move up in the world. I was thinking about how I wanted to leave the world in better shape for my family. I returned to work with my doctor’s “okay” to bring in as much money as I could, while I could. I was consistently working full days. Life seemed almost normal!

[At] an appointment with my radiation oncologist, he asked me if I’d be interested in trying a medical device called Optune for the treatment of GBM and walked through the risks and benefits with me. I considered it as an opportunity to hopefully extend whatever time I had left. They couldn’t say Optune was the solution, but I think I’ve always had the same attitude when it comes to treatment: I have nothing to lose and everything to gain.

Knowing that the monthly usage target for wearing Optune should be 18 hours per day, my main concern was how I would continue traveling for work while maximizing my time on Optune. I cleared this with my doctor and I learned that, luckily, Novocure will work with me to ship my supplies to my hotel—even on short notice.

Occasionally, I have skin irritation from the arrays, and I have bought a cooling pillow and a fan to keep my head cool, especially during the summer months. I make sure to talk to my doctor about any side effects I experience on treatment.

I am still working full-time at a desk job and maintain some of my hobbies, like woodworking. So far, it’s been awesome.

Dear Optune User,

I love to travel. How easy is it to continue with treatment while on the go?

I also love to travel. And with nCompass there to support me, I have had no trouble staying on Optune and on the go. In fact, I once planned an extended camping trip and, with the help of my DSS, was able to get extra sets of batteries to take with me.

Because of that, I was able to enjoy my trip without worrying about losing time on Optune.

It was a relief to know that I could continue fighting GBM, even while disconnecting in the great outdoors.

Eric

Dear Optune User,

How do you stay cool wearing Optune during hot weather?

Some warming sensation can be expected while using Optune, which can be uncomfortable during warm weather months.

While most people get used to this quickly, I have found that a cooling pillow helps me sleep with Optune on.

And, when I am out in the heat, I am able to stay cool with a solar-powered, fan-equipped hat that I made myself.

But, remember, if you notice any change in your health, including being especially uncomfortable or experiencing a rash, sores, or skin ulcers on your scalp, please contact your doctor immediately.

Taylor

Contact nCompass for 24/7 personalized support by phone or email

Darrell is an Optune User. Andrea is his wife and caregiver.

©2019 Novocure. All rights reserved. Optune, nCompass, and Novocure are trademarks of Novocure. US-OPT-02421

The MRI results of my brain, … showed a mass about the size of a golf ball just behind my left eye. A tumor, they told me. Okay, well, what’s gonna happen to me? They mentioned something about “a large tumor,” but I informed them, unless I was going to die tomorrow, I had work to finish and a whole group of people dependent on it. Two days later, after the release (because there was not an earlier flight), I was on a flight home, having promised to follow up with our family doctor.

Four days later, after an appointment with a neurosurgeon and additional MRIs, I underwent surgery to remove what we could of the tumor. It’s while I was recovering that my diagnosis of glioblastoma was confirmed.

Once I recovered from surgery, I started my six weeks with chemotherapy and radiation—and I had, and still have, MRIs every two months to keep track of the cancer’s activity.

“What’s gonna happen to me?”

I grew up in Alaska. My siblings and I spent most of our time looking for ways to entertain ourselves ... or hiding from Dad, who always had some kind of work for us to do. Repairing and making stuff himself was a way of life for him.

The thing about woodworking, … is that [it requires] an incredible amount of resourcefulness, problem-solving, and attention to detail. You sort of have to figure things out as you go, no matter how daunting. The same can be said about living with glioblastoma.

I was on a business trip one weekend, out walking around and thinking about how important this software release I was working on was going to be. Next thing I knew, I was coming to, flat on my back with my feet on the sidewalk, my upper body in the street, and lots of people talking above me, saying stuff I couldn’t follow. Then, it was a whole bunch of ER doctors saying stuff above me that I really couldn’t follow.

Meet Brian, an Optune user

Meeting the Optune CommunityFind out about different ways you can connect with Optune users.

Optune User’s ColumnLong-time users give personal answers to frequently asked questions about life with Optune.

Planning a Summer Vacation?nCompass™ can provide the support you need to travel with Optune.

What’s inside

Marcia is an Optune user. BT is her husband and caregiver.

Optune® Community Newsletter Made by Optune users for people with GBM.

After chemotherapy and radiation, Taylor’s radiation oncologist introduced him to Optune. He was very interested in Optune because, he felt

Buddy Program Ambassador Spotlight: Taylor, Optune User

Taylor was diagnosed with glioblastoma at the age of 31. After having worsening headaches over the course of a week, his wife took him to the ER where they did a CT scan. Unfortunately, the scan showed a large mass behind Taylor’s left eye.

Taylor had surgery, where his neurosurgeon was able to get 90% of the tumor out. Several weeks later, he was officially diagnosed with a grade 4 glioblastoma.

Meeting the Optune Community

Optune Open Houses are live educational events where you can:• Learn more about GBM and Optune• Hear firsthand from Optune users and caregivers about starting

and incorporating Optune into daily life

The Optune Buddy Program connects you with users and/or caregivers who want to share what they’ve learned with you.*

Some things you can talk to a current user or caregiver about include:• Personal experiences with GBM and Optune• How they incorporated Optune into their daily lives• Navigating challenges and finding support

“ this was a way to keep fighting the cancer. If we were fighting, we had reason to hope. What more can you ask for when you’re given a life sentence?”

* Please note that an Optune user or caregiver cannot provide you with medical advice because each person is different. Consult with your doctor for medically related questions.

Visit Optune.com to find out more

Laura is an Optune user.

Discover more at Optune.com

What is Optune® approved to treat?

Optune is a wearable, portable, FDA-approved device indicated to treat a type of brain cancer called glioblastoma multiforme (GBM) in adult patients 22 years of age or older.

Newly diagnosed GBMIf you have newly diagnosed GBM, Optune is used together with a chemotherapy called temozolomide (TMZ) if:

• Your cancer is confirmed by your healthcare professional AND• You have had surgery to remove as much of the tumor as possible

Recurrent GBMIf your tumor has come back, Optune can be used alone as an alternative to standard medical therapy if:

• You have tried surgery and radiation and they did not work or are no longer working AND• You have tried chemotherapy and your GBM has been confirmed by your healthcare professional

Who should not use Optune?

Optune is not for everyone. Talk to your doctor if you have:

• An implanted medical device (programmable shunt), skull defect (missing bone with no replacement), or bullet fragment. Optune has not been tested in people with implanted electronic devices, which may cause the devices not to work properly, and Optune has not been tested in people with skull defects or bullet fragments, which may cause Optune not to work properly

• A known sensitivity to conductive hydrogels (the gel on the arrays placed on the scalp like the ones used on EKGs). When Optune comes into contact with the skin, it may cause more redness and itching or may rarely cause a life-threatening allergic reaction

Do not use Optune if you are pregnant or are planning to become pregnant. It is not known if Optune is safe or effective during pregnancy.

What should I know before using Optune?

Optune should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure®, the maker of Optune.

• Do not use any parts that did not come with the Optune Treatment Kit sent to you by Novocure or given to you by your doctor

• Do not get the device or transducer arrays wet

• If you have an underlying serious skin condition on the scalp, discuss with your doctor whether this may prevent or temporarily interfere with Optune treatment

What are the possible side effects of Optune?

Most common side effects of Optune when used together with chemotherapy (temozolomide, or TMZ) were low blood platelet count, nausea, constipation, vomiting, tiredness, scalp irritation from the device, headache, seizure, and depression.

The most common side effects when using Optune alone were scalp irritation (redness and itchiness) and headache. Other side effects were malaise, muscle twitching, fall and skin ulcers.

Talk to your doctor if you have any of these side effects or questions.

Please visit Optune.com/Safety for the Optune Patient Information and Operation Manual and complete information regarding the device’s indications, contraindications, warnings, and precautions.

Patient images reflect the health status of the patients at the time each photo was taken.

Brian is an Optune user. Susan is his wife and caregiver.