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?. “ β -blocker IMPROVES PROGNOSIS in CAD patients”: Is this still so when they are part of moderN treatment?. Bangalore S, et al. β -Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA . 2012;308(13):1340-1349. Objectives & methods. - PowerPoint PPT Presentation
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Bangalore S, et al. β-Blocker use and clinical outcomes in stable
outpatients with and without coronary artery disease. JAMA.
2012;308(13):1340-1349.
?“β-BLOCKER IMPROVES PROGNOSIS IN CAD PATIENTS”: IS THIS STILL SO WHEN THEY ARE PART OF MODERN TREATMENT?
Background: The evidence for β-blocker use is derived from post—myocardial infarction (MI) studies antedating modern
reperfusion or medical therapy, and has been widely extrapolated to all patients with coronary artery disease (CAD).
Long-term efficacy of β-blocker use in patients treated with contemporary medical therapies is not known, even in patients with prior MI.
Objectives The objective of the analysis of the REACH (REduction of Atherothrombosis for Continued Health) registry was to
assess the association of β-blocker use with cardiovascular events in patients with a prior MI, in those with CAD without MI, and in those with CAD risk factors only.
Methods• The population in the REACH registry was divided into 3 cohorts:
known prior MI known CAD without MI CAD risk factors only
• Propensity score matching was used for the analysis, resulting in 21 860 patients included in the propensity score—matched analysis .
• Median follow-up was 44 months. • The primary outcome was a composite of cardiovascular death, nonfatal MI, or nonfatal stroke. • The secondary outcome was the primary outcome plus hospitalization or a revascularization.
OBJECTIVES & METHODS
NO PROGNOSTIC VALUE OF β-BLOCKERS IN STABLE CORONARY PATIENTS
21 860 Patients with or without stable CAD from the REACH registry, 44 months of follow-up
Bangalore S, et al. JAMA. 2012;308(13):1340-1349.
3
Stable CAD with
MI
Stable CAD without
MI
HR 0.90
P=0.14
HR 0.92
P=0.31
HR 1.18
P=0.02
Event rate for the primary outcome -- composite of cardiovascular death, nonfatal MI, or nonfatal stroke,
%
With risk factors only
(no CAD)
NO PROGNOSTIC VALUE OF β-BLOCKERS IN STABLE CORONARY PATIENTS
Bangalore S, et al. JAMA. 2012;308(13):1340-1349.
IMPLICATIONS FOR CLINICAL PRACTICE
• These results showed that despite the perception that β-blockers are
beneficial in all stable CAD patients, their use in the era of modern
medical and reperfusion therapy in stable CAD patients is not associated
with lower cardiovascular event rates.
• These findings raise questions regarding the need for long-term use of β-
blockers in patients 1 year after MI or in those who had percutaneous
coronary intervention (PCI) or coronary artery bypass grafting (CABG)
without MI.