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Physiology of:
Oxygen Carrying System
V. Sutarmo Setiadji
4 February 200 VSS
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4 February 200 VSS
Cardio!ulmonary:
". Cir#ulatory System
$ %eart
$ Vas#ulatory system
$ &rterial
$ Ca!illary$ Venous
2. 'es!iratory System
$ &ir !ath(ay $ )ungs
*. +lood
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4 February 200 VSS
Cir#ulatory SystemFun#tions:
$ Cir#ulating oxygen that #ome fromres!iratory system, nutrients
from the
digesti-e system, and hormones and
other #hemi#als, to all !arts of the body$ +ring the (aste from
#ell and
inter#ellular fluid to the ex#retory organs
maintain the stable #onditions of the
internal en-ironment homeostasis/
Consist of:
$ he heart and the blood -essels
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20 O1tober 200 VSS
3antung berfungsi memom!a darah
meru!a1an 2 !om!ayang tersusun seri
&trium 1anan-entri1el.
1anana. !ulmonalis
!aru-. !ulmonalisatrium 1iri-entri1el
1iriaortaseluruh
tubuh-ena 1a-aatrium 1anan
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"2$ O1tober $ 20020O1tober 200 VSSVSS20 O1tober 200 VSS
3antung tersusun
terutama dari ototjantung.
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"2$ O1tober $ 20020O1tober 200 5VSSVSS20 O1tober 200 VSS
Sifat$sifat otot jantung
". 6ondu1ti-itas
2. 6ontra1tilitas
*. &utomasi
4. 'itmisitas
. 7embentu1 sinsisium5. 7em!unyai masa refra1ter yang
!anjang
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'es!iratory System
Fun#tion:
8!ta1e oxygen O2/ from the atmosfer
and deli-er CO2to the atmosfer
hese fun#tion must be su!!orted by #ir#ulatory
system
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Gas Law
he beha-ior of all gases is affe#ted by three
fa#tors: $ the tem!erature of the gas,
$ the !ressure of the gas, and
$ the -olume of the gas.
he relationshi!s among these three fa#tors ha-e
been defined in (hat are #alled the 9as )a(s.
Fi-e of these, Dalton's Law, Boyle's Law,Charles' Law, Henry's
Law, and the General
Gas Law, are of s!e#ial im!ortan#e to the diver.
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14
Transport of Oxygen
1. From alveolus, O2 diuse to the blood.2. In the blood, O2exist
in to forms!
a. "s a physi#al solutionb. In #ombination ith ferrous iron atom
in th %the rea#tion is not oxydation but oxygenati
$b4 ' O2 $b4O2
$b4O2 ' O2 $b4O4
$b4O4 ' O2 $b4O(
$b4O( ' O2 $b4O)
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1*
$aemoglobin %$b& is a protein made up of foursubunits, ea#h
of hi#h #ontains a heme moietyatta#hed to a polypeptide #hain.
$eme is a #omplex of porphyrin and one atom oferous iron.
Ferrous iron #an bind reversibly one
+ole#ule by rea#tion of oxygenation.
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1(
1. ystems involve in the delivery of oxyg the tissues are - the
lungs
- the #ardiovas#ular syste2. O2delivery to a parti#ular tissue
depen
- the amount of O2entering the lungs
- the adeua#y of pulmonary gas ex#h - the blood /o to the tissue
- vas#ular resistan#e in the tis- #ardia# output
- the amount of O2in the blood
- the amount of dissolved O2- the amount of $b in the bloo
- the a0nity of the $b for O2
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(21* VSS
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7ass balan#e
;xisting body load
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Sel mem!unyai me1anisme !ertahanan dalam
mem!ertahan1an -olumenya.7e1anisme !ertahanan itu sering
disebut:
'egulatory -olume de#rease 'V>/
&tau
'egulatory -olume in#rease 'V=/
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