115
TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47 Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03 Species/Strain: RATS/F 344/N Lab: BNW F3_R2 C Number: C93025 Lock Date: 03/22/2006 Cage Range: ALL Date Range: ALL Reasons For Removal: ALL Removal Date Range: ALL Treatment Groups: Include ALL Study Gender: Both TDMSE Version: 2.1.0 Note: Animals arranged according to days on test.

ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

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Page 1: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

F3_R2

C Number: C93025

Lock Date: 03/22/2006

Cage Range: ALL

Date Range: ALL

Reasons For Removal: ALL

Removal Date Range: ALL

Treatment Groups: Include ALL

Study Gender: Both

TDMSE Version: 2.1.0

Note: Animals arranged according to days on test.

Page 2: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + A + + + + + + + + + + + + + + A A.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + A + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + A + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + A + + A + + + + + + + + + + + A + + A A.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + A + + A + + + + + + + + + + + A + + + A.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +

Hepatocellular Adenoma.........................................................................................................................................................................................................

Mesentery + + + + +.........................................................................................................................................................................................................

Oral Mucosa.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0372

0530

0557

0563

0563

0586

0586

0591

0593

0600

0600

0605

0628

0642

0642

0647

0647

0647

0648

0649

0662

0668

0670

0678

0682

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00040

00047

00025

00039

00045

00012

00016

00009

00050

00014

00020

00021

00001

00003

00028

00008

00035

00044

00043

00018

00048

00006

00013

00031

00037

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 2

Page 3: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Tongue.........................................................................................................................................................................................................

Tooth +

Adamantinoma Malignant X

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +

Pheochromocytoma Benign X X X X

Pheochromocytoma Malignant X

Bilateral, Pheochromocytoma Benign X

Bilateral, Pheochromocytoma Malignant

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0372

0530

0557

0563

0563

0586

0586

0591

0593

0600

0600

0605

0628

0642

0642

0647

0647

0647

0648

0649

0662

0668

0670

0678

0682

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00040

00047

00025

00039

00045

00012

00016

00009

00050

00014

00020

00021

00001

00003

00028

00008

00035

00044

00043

00018

00048

00006

00013

00031

00037

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 3

Page 4: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X

Carcinoma.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + + + + + + + + M + + + + + + + +.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X X X X X X X X X X X X X X X X X

Carcinoma.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

C-cell, Adenoma X

C-cell, Carcinoma

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Penis +.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0372

0530

0557

0563

0563

0586

0586

0591

0593

0600

0600

0605

0628

0642

0642

0647

0647

0647

0648

0649

0662

0668

0670

0678

0682

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00040

00047

00025

00039

00045

00012

00016

00009

00050

00014

00020

00021

00001

00003

00028

00008

00035

00044

00043

00018

00048

00006

00013

00031

00037

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 4

Page 5: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + +

Bilateral, Interstitial Cell, Adenoma X X X X X X

Interstitial Cell, Adenoma X X

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node + + + +.........................................................................................................................................................................................................

Lymph Node, Bronchial M M M M M M M M + M + M M M M + + M + M M M M M M.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + M M M M + + + M + + + M + + + M + M + + +

Carcinoma, Metastatic, Thyroid Gland.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0372

0530

0557

0563

0563

0586

0586

0591

0593

0600

0600

0605

0628

0642

0642

0647

0647

0647

0648

0649

0662

0668

0670

0678

0682

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00040

00047

00025

00039

00045

00012

00016

00009

00050

00014

00020

00021

00001

00003

00028

00008

00035

00044

00043

00018

00048

00006

00013

00031

00037

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 5

Page 6: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Thymus + + M + + M M + + + + + + + + + + + + + + + + + +

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Fibroadenoma.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +

Basal Cell Adenoma, Multiple

Basal Cell Carcinoma

Keratoacanthoma, Multiple

Sebaceous Gland, Adenoma

Subcutaneous Tissue, Fibroma X X

Subcutaneous Tissue, Fibrosarcoma X

Subcutaneous Tissue,Hemangiosarcoma

Subcutaneous Tissue, Osteosarcoma,Metastatic, Bone

X

Subcutaneous Tissue, SchwannomaMalignant

MUSCULOSKELETAL SYSTEM

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0372

0530

0557

0563

0563

0586

0586

0591

0593

0600

0600

0605

0628

0642

0642

0647

0647

0647

0648

0649

0662

0668

0670

0678

0682

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00040

00047

00025

00039

00045

00012

00016

00009

00050

00014

00020

00021

00001

00003

00028

00008

00035

00044

00043

00018

00048

00006

00013

00031

00037

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 6

Page 7: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Bone + + + + + + + + + + + + + + + + + + + + + + + + +

Osteosarcoma X X

Maxilla, Osteosarcoma

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Pituitary Gland

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + +

Alveolar/Bronchiolar Carcinoma

Osteosarcoma, Metastatic, Bone X

Pheochromocytoma Malignant,Metastatic, Adrenal Medulla

X

.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Pleura

.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0372

0530

0557

0563

0563

0586

0586

0591

0593

0600

0600

0605

0628

0642

0642

0647

0647

0647

0648

0649

0662

0668

0670

0678

0682

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00040

00047

00025

00039

00045

00012

00016

00009

00050

00014

00020

00021

00001

00003

00028

00008

00035

00044

00043

00018

00048

00006

00013

00031

00037

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 7

Page 8: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +

Leukemia Mononuclear X X X X X X X X X X X X X X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0372

0530

0557

0563

0563

0586

0586

0591

0593

0600

0600

0605

0628

0642

0642

0647

0647

0647

0648

0649

0662

0668

0670

0678

0682

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00040

00047

00025

00039

00045

00012

00016

00009

00050

00014

00020

00021

00001

00003

00028

00008

00035

00044

00043

00018

00048

00006

00013

00031

00037

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 8

Page 9: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Cecum + A + + + + + + + + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Small, Ileum + A + + + + + + + + + + + + + + + + + + + + + + + 44.........................................................................................................................................................................................................

Intestine Small, Jejunum + A + + + + + + + + + + + + + + + + + + + + + + + 45.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50

Hepatocellular Adenoma X 1.........................................................................................................................................................................................................

Mesentery + + + + + + + + + + 15.........................................................................................................................................................................................................

Oral Mucosa + 1.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0684

0701

0712

0718

0726

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00005

00022

00010

00026

00027

00004

00011

00015

00017

00023

00024

00029

00030

00032

00033

00036

00038

00041

00042

00046

00049

00002

00007

00019

00034 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 9

Page 10: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Tongue + 1.........................................................................................................................................................................................................

Tooth + + 3

Adamantinoma Malignant 1

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pheochromocytoma Benign X X X 7

Pheochromocytoma Malignant X X 3

Bilateral, Pheochromocytoma Benign X 2

Bilateral, Pheochromocytoma Malignant X 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0684

0701

0712

0718

0726

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00005

00022

00010

00026

00027

00004

00011

00015

00017

00023

00024

00029

00030

00032

00033

00036

00038

00041

00042

00046

00049

00002

00007

00019

00034 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 10

Page 11: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X 3

Carcinoma X 1.........................................................................................................................................................................................................

Parathyroid Gland + M + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X X X X X X X X X X X X X X X X X 36

Carcinoma X 1.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

C-cell, Adenoma X X X X 5

C-cell, Carcinoma X X 2

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Penis 1.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0684

0701

0712

0718

0726

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00005

00022

00010

00026

00027

00004

00011

00015

00017

00023

00024

00029

00030

00032

00033

00036

00038

00041

00042

00046

00049

00002

00007

00019

00034 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 11

Page 12: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50

Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X X X 18

Interstitial Cell, Adenoma X X X X X X X X X 11

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lymph Node + + + + 8.........................................................................................................................................................................................................

Lymph Node, Bronchial M M M M M M M M M M M + M M M M M M M M M M M M + 7.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + M + + M + + M M + + + + + M M + + + M + + M M 33

Carcinoma, Metastatic, Thyroid Gland X 1.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0684

0701

0712

0718

0726

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00005

00022

00010

00026

00027

00004

00011

00015

00017

00023

00024

00029

00030

00032

00033

00036

00038

00041

00042

00046

00049

00002

00007

00019

00034 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 12

Page 13: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 47

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Fibroadenoma X 1.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50

Basal Cell Adenoma, Multiple X 1

Basal Cell Carcinoma X X X 3

Keratoacanthoma, Multiple X 1

Sebaceous Gland, Adenoma X X 2

Subcutaneous Tissue, Fibroma X 3

Subcutaneous Tissue, Fibrosarcoma X X 3

Subcutaneous Tissue,Hemangiosarcoma

X 1

Subcutaneous Tissue, Osteosarcoma,Metastatic, Bone

1

Subcutaneous Tissue, SchwannomaMalignant

X 1

MUSCULOSKELETAL SYSTEM

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0684

0701

0712

0718

0726

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00005

00022

00010

00026

00027

00004

00011

00015

00017

00023

00024

00029

00030

00032

00033

00036

00038

00041

00042

00046

00049

00002

00007

00019

00034 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 13

Page 14: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

Osteosarcoma 2

Maxilla, Osteosarcoma X 1

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Pituitary Gland X 1

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50

Alveolar/Bronchiolar Carcinoma X 1

Osteosarcoma, Metastatic, Bone 1

Pheochromocytoma Malignant,Metastatic, Adrenal Medulla

X 2

.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50

.........................................................................................................................................................................................................Pleura + + 2

.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0684

0701

0712

0718

0726

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00005

00022

00010

00026

00027

00004

00011

00015

00017

00023

00024

00029

00030

00032

00033

00036

00038

00041

00042

00046

00049

00002

00007

00019

00034 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 14

Page 15: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Leukemia Mononuclear X X X X X X X X X X X 25

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0684

0701

0712

0718

0726

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

CONTROL

00005

00022

00010

00026

00027

00004

00011

00015

00017

00023

00024

00029

00030

00032

00033

00036

00038

00041

00042

00046

00049

00002

00007

00019

00034 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 15

Page 16: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum A + + + + + + + + + + A + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Colon A + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum A + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum A + + + + + + + + + + A + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Jejunum A + + + + + + + + + + A + + A + + + + + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Mesentery + + + + + +.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0500

0513

0547

0560

0563

0563

0576

0582

0590

0633

0642

0663

0670

0674

0676

0696

0715

0715

0716

0722

0722

0729

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00239

00220

00249

00242

00226

00240

00223

00230

00217

00210

00216

00245

00224

00209

00244

00213

00201

00248

00228

00237

00243

00203

00204

00206

00207

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 16

Page 17: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Tongue

Squamous Cell Papilloma.........................................................................................................................................................................................................

Tooth

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +

Alveolar/Bronchiolar Carcinoma,Metastatic, Lung

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X

.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +

Pheochromocytoma Benign X X

Pheochromocytoma Malignant X

Bilateral, Pheochromocytoma Benign.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0500

0513

0547

0560

0563

0563

0576

0582

0590

0633

0642

0663

0670

0674

0676

0696

0715

0715

0716

0722

0722

0729

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00239

00220

00249

00242

00226

00240

00223

00230

00217

00210

00216

00245

00224

00209

00244

00213

00201

00248

00228

00237

00243

00203

00204

00206

00207

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 17

Page 18: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X

Carcinoma X

.........................................................................................................................................................................................................Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X X X X X X X X X X X X X X X X X X

.........................................................................................................................................................................................................Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Bilateral, C-cell, Adenoma

C-cell, Adenoma X

C-cell, Carcinoma X

Follicular Cell, Adenoma

Follicular Cell, Carcinoma X

GENERAL BODY SYSTEM.........................................................................................................................................................................................................

Peritoneum + +

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0500

0513

0547

0560

0563

0563

0576

0582

0590

0633

0642

0663

0670

0674

0676

0696

0715

0715

0716

0722

0722

0729

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00239

00220

00249

00242

00226

00240

00223

00230

00217

00210

00216

00245

00224

00209

00244

00213

00201

00248

00228

00237

00243

00203

00204

00206

00207

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 18

Page 19: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + +

Bilateral, Interstitial Cell, Adenoma X X X X X X X X

Interstitial Cell, Adenoma X X X X X X X X

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node + +.........................................................................................................................................................................................................

Lymph Node, Bronchial M M M M M M M M M M M M M M M M M M + + + M M M M.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M M M M M M M M M M M M + M M M M M M M M.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + + M M + + M + + + + + + + + M + + + + +.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0500

0513

0547

0560

0563

0563

0576

0582

0590

0633

0642

0663

0670

0674

0676

0696

0715

0715

0716

0722

0722

0729

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00239

00220

00249

00242

00226

00240

00223

00230

00217

00210

00216

00245

00224

00209

00244

00213

00201

00248

00228

00237

00243

00203

00204

00206

00207

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 19

Page 20: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Thymus + + + + + + + + + + + + + + + + + + + + + + + + M

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma

Fibroadenoma X

.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +

Basal Cell Carcinoma

Keratoacanthoma

Osteosarcoma

Squamous Cell Papilloma X

Pinna, Neural Crest Tumor

Subcutaneous Tissue, Fibroma X X

Subcutaneous Tissue, Fibrosarcoma X

Subcutaneous Tissue, SchwannomaBenign

Subcutaneous Tissue, SchwannomaMalignant, Multiple

MUSCULOSKELETAL SYSTEM

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0500

0513

0547

0560

0563

0563

0576

0582

0590

0633

0642

0663

0670

0674

0676

0696

0715

0715

0716

0722

0722

0729

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00239

00220

00249

00242

00226

00240

00223

00230

00217

00210

00216

00245

00224

00209

00244

00213

00201

00248

00228

00237

00243

00203

00204

00206

00207

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 20

Page 21: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Bone + + + + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + +

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + +

Alveolar/Bronchiolar Carcinoma.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Pleura.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0500

0513

0547

0560

0563

0563

0576

0582

0590

0633

0642

0663

0670

0674

0676

0696

0715

0715

0716

0722

0722

0729

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00239

00220

00249

00242

00226

00240

00223

00230

00217

00210

00216

00245

00224

00209

00244

00213

00201

00248

00228

00237

00243

00203

00204

00206

00207

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 21

Page 22: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +

Cortex, Renal Tubule, Adenoma.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +

Histiocytic Sarcoma X

Leukemia Mononuclear X X X X X X X X X

Mesothelioma Malignant X X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0500

0513

0547

0560

0563

0563

0576

0582

0590

0633

0642

0663

0670

0674

0676

0696

0715

0715

0716

0722

0722

0729

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00239

00220

00249

00242

00226

00240

00223

00230

00217

00210

00216

00245

00224

00209

00244

00213

00201

00248

00228

00237

00243

00203

00204

00206

00207

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 22

Page 23: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + A + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + A + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + A + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Mesentery + + + + + + + 13.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00212

00214

00215

00218

00219

00227

00229

00231

00232

00233

00235

00238

00246

00247

00202

00205

00208

00211

00221

00222

00225

00234

00236

00241

00250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 23

Page 24: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50

.........................................................................................................................................................................................................Tongue + + + 3

Squamous Cell Papilloma X 1.........................................................................................................................................................................................................

Tooth + + 2

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50

Alveolar/Bronchiolar Carcinoma,Metastatic, Lung

X 1

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma 1.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pheochromocytoma Benign X X X X X X 8

Pheochromocytoma Malignant X 2

Bilateral, Pheochromocytoma Benign X X 2.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00212

00214

00215

00218

00219

00227

00229

00231

00232

00233

00235

00238

00246

00247

00202

00205

00208

00211

00221

00222

00225

00234

00236

00241

00250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 24

Page 25: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X X 4

Carcinoma X X X 4.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Pituitary Gland + + + + + + M + + + + + + + + + + + + + + + + + + 49

Adenoma X X X X X X X X X X X X X X X X 35.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Bilateral, C-cell, Adenoma X 1

C-cell, Adenoma X X 3

C-cell, Carcinoma X X X 4

Follicular Cell, Adenoma X 1

Follicular Cell, Carcinoma 1

GENERAL BODY SYSTEM.........................................................................................................................................................................................................

Peritoneum 2

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00212

00214

00215

00218

00219

00227

00229

00231

00232

00233

00235

00238

00246

00247

00202

00205

00208

00211

00221

00222

00225

00234

00236

00241

00250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 25

Page 26: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50

Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X X X 20

Interstitial Cell, Adenoma X X X X X X X X X X X 19

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lymph Node 2.........................................................................................................................................................................................................

Lymph Node, Bronchial M M M M M M + + M M M M M M M M M M M M M M M M M 5.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 1.........................................................................................................................................................................................................

Lymph Node, Mediastinal M + + + M + M M + M + M M M + + + + + + + + + M M 36.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00212

00214

00215

00218

00219

00227

00229

00231

00232

00233

00235

00238

00246

00247

00202

00205

00208

00211

00221

00222

00225

00234

00236

00241

00250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 26

Page 27: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Thymus + + + + + + M + + M + M M M + + + + + + + + M + + 43

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X 1

Fibroadenoma 1.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50

Basal Cell Carcinoma X 1

Keratoacanthoma X 1

Osteosarcoma X 1

Squamous Cell Papilloma 1

Pinna, Neural Crest Tumor X 1

Subcutaneous Tissue, Fibroma X X 4

Subcutaneous Tissue, Fibrosarcoma 1

Subcutaneous Tissue, SchwannomaBenign

X 1

Subcutaneous Tissue, SchwannomaMalignant, Multiple

X 1

MUSCULOSKELETAL SYSTEM

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00212

00214

00215

00218

00219

00227

00229

00231

00232

00233

00235

00238

00246

00247

00202

00205

00208

00211

00221

00222

00225

00234

00236

00241

00250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 27

Page 28: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50

Alveolar/Bronchiolar Carcinoma X X 2.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Pleura + 1.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + M + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00212

00214

00215

00218

00219

00227

00229

00231

00232

00233

00235

00238

00246

00247

00202

00205

00208

00211

00221

00222

00225

00234

00236

00241

00250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 28

Page 29: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50

Cortex, Renal Tubule, Adenoma X 1.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1

Leukemia Mononuclear X X X X X X X 16

Mesothelioma Malignant 2

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

30 PPM

00212

00214

00215

00218

00219

00227

00229

00231

00232

00233

00235

00238

00246

00247

00202

00205

00208

00211

00221

00222

00225

00234

00236

00241

00250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 29

Page 30: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + A + + + + + + + + A A + + + + + + + + + + + A.........................................................................................................................................................................................................

Intestine Large, Colon + + A + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum + A A + + + + + + + + A A + + + + + + + + + + + A.........................................................................................................................................................................................................

Intestine Small, Jejunum + A A + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Mesentery + + + + + +.........................................................................................................................................................................................................

Oral Mucosa +.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0438

0480

0483

0523

0537

0547

0561

0600

0614

0619

0621

0623

0625

0640

0642

0647

0662

0662

0689

0689

0691

0698

0718

0719

0724

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00419

00444

00445

00446

00402

00403

00416

00433

00415

00412

00439

00409

00420

00423

00429

00450

00428

00434

00431

00449

00441

00442

00436

00422

00407

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 30

Page 31: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Tongue.........................................................................................................................................................................................................

Tooth +

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +

Pheochromocytoma Benign X X X X X X X

Pheochromocytoma Complex X

Pheochromocytoma Malignant.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0438

0480

0483

0523

0537

0547

0561

0600

0614

0619

0621

0623

0625

0640

0642

0647

0662

0662

0689

0689

0691

0698

0718

0719

0724

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00419

00444

00445

00446

00402

00403

00416

00433

00415

00412

00439

00409

00420

00423

00429

00450

00428

00434

00431

00449

00441

00442

00436

00422

00407

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 31

Page 32: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X

Carcinoma X

.........................................................................................................................................................................................................Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X X X X X X X X X X X X X X X X

Carcinoma.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Bilateral, C-cell, Adenoma

C-cell, Adenoma X X

C-cell, Carcinoma X X

Follicular Cell, Adenoma X

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0438

0480

0483

0523

0537

0547

0561

0600

0614

0619

0621

0623

0625

0640

0642

0647

0662

0662

0689

0689

0691

0698

0718

0719

0724

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00419

00444

00445

00446

00402

00403

00416

00433

00415

00412

00439

00409

00420

00423

00429

00450

00428

00434

00431

00449

00441

00442

00436

00422

00407

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 32

Page 33: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Adenoma

Carcinoma X

.........................................................................................................................................................................................................Prostate + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X

.........................................................................................................................................................................................................Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Testes + + + + + + + + + + + + + + + + + + + + + + + + +

Bilateral, Interstitial Cell, Adenoma X X X X X X X

Interstitial Cell, Adenoma X X X X X

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node + + + + + +

Deep Cervical, Carcinoma, Metastatic,Thyroid Gland

X

.........................................................................................................................................................................................................Lymph Node, Bronchial M M M M M M M M M M + M + M M M M + M M M M M M M

.........................................................................................................................................................................................................Lymph Node, Mandibular + M M M M M + M M M M M M M M M M M M M M M M M M

.........................................................................................................................................................................................................Lymph Node, Mediastinal + + + + M M + + + + + M + + + + + + M + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0438

0480

0483

0523

0537

0547

0561

0600

0614

0619

0621

0623

0625

0640

0642

0647

0662

0662

0689

0689

0691

0698

0718

0719

0724

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00419

00444

00445

00446

00402

00403

00416

00433

00415

00412

00439

00409

00420

00423

00429

00450

00428

00434

00431

00449

00441

00442

00436

00422

00407

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 33

Page 34: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Fibrous Histiocytoma, Metastatic, Skin.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Thymus + + + + M + + + + + + + + + + + + + M + + + + + +

Thymoma Benign

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X

.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +

Basal Cell Carcinoma X X

Keratoacanthoma

Squamous Cell Carcinoma

Squamous Cell Papilloma X

Subcutaneous Tissue, Fibroma

Subcutaneous Tissue, Fibrosarcoma X

Subcutaneous Tissue, FibrousHistiocytoma

Subcutaneous Tissue, Lipoma

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0438

0480

0483

0523

0537

0547

0561

0600

0614

0619

0621

0623

0625

0640

0642

0647

0662

0662

0689

0689

0691

0698

0718

0719

0724

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00419

00444

00445

00446

00402

00403

00416

00433

00415

00412

00439

00409

00420

00423

00429

00450

00428

00434

00431

00449

00441

00442

00436

00422

00407

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 34

Page 35: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Subcutaneous Tissue, Sarcoma

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + +

Cranium, Osteosarcoma X

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Pituitary Gland

Osteosarcoma, Metastatic, Bone X

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + +

Alveolar/Bronchiolar Adenoma X

Alveolar/Bronchiolar Carcinoma

Pheochromocytoma Complex,Metastatic, Adrenal Medulla

X

.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0438

0480

0483

0523

0537

0547

0561

0600

0614

0619

0621

0623

0625

0640

0642

0647

0662

0662

0689

0689

0691

0698

0718

0719

0724

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00419

00444

00445

00446

00402

00403

00416

00433

00415

00412

00439

00409

00420

00423

00429

00450

00428

00434

00431

00449

00441

00442

00436

00422

00407

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 35

Page 36: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Nose + + + + + + + + + + + + A + + + + + + + + + + + +

Adenoma, Tubular.........................................................................................................................................................................................................

Pleura.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + A A + + + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Zymbal's Gland +

Carcinoma X

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +

Cortex, Renal Tubule, Adenoma.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +

SYSTEMIC LESIONS

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0438

0480

0483

0523

0537

0547

0561

0600

0614

0619

0621

0623

0625

0640

0642

0647

0662

0662

0689

0689

0691

0698

0718

0719

0724

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00419

00444

00445

00446

00402

00403

00416

00433

00415

00412

00439

00409

00420

00423

00429

00450

00428

00434

00431

00449

00441

00442

00436

00422

00407

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 36

Page 37: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +

Leukemia Mononuclear X X X X

Mesothelioma Malignant

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0438

0480

0483

0523

0537

0547

0561

0600

0614

0619

0621

0623

0625

0640

0642

0647

0662

0662

0689

0689

0691

0698

0718

0719

0724

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00419

00444

00445

00446

00402

00403

00416

00433

00415

00412

00439

00409

00420

00423

00429

00450

00428

00434

00431

00449

00441

00442

00436

00422

00407

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 37

Page 38: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 45.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 46.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Mesentery + + + + + + 12.........................................................................................................................................................................................................

Oral Mucosa + + 3.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X 1.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00405

00408

00410

00411

00414

00417

00418

00424

00425

00426

00427

00432

00435

00437

00447

00448

00401

00404

00406

00413

00421

00430

00438

00440

00443 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 38

Page 39: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Tongue + + + 3.........................................................................................................................................................................................................

Tooth 1

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + M + + + + + + 49

Adenoma X X X 3.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + M + + + + + + 49

Pheochromocytoma Benign X X X X X 12

Pheochromocytoma Complex 1

Pheochromocytoma Malignant X 1.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00405

00408

00410

00411

00414

00417

00418

00424

00425

00426

00427

00432

00435

00437

00447

00448

00401

00404

00406

00413

00421

00430

00438

00440

00443 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 39

Page 40: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X 4

Carcinoma X X 3.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + M + + + 49

Adenoma X X X X X X X X X X X X X X X X X X X 36

Carcinoma X 1.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Bilateral, C-cell, Adenoma X 1

C-cell, Adenoma X X 4

C-cell, Carcinoma 2

Follicular Cell, Adenoma X 2

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00405

00408

00410

00411

00414

00417

00418

00424

00425

00426

00427

00432

00435

00437

00447

00448

00401

00404

00406

00413

00421

00430

00438

00440

00443 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 40

Page 41: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Adenoma X 1

Carcinoma 1.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma 1.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50

Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X 17

Interstitial Cell, Adenoma X X X X X X X X X 14

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lymph Node + 7

Deep Cervical, Carcinoma, Metastatic,Thyroid Gland

1

.........................................................................................................................................................................................................Lymph Node, Bronchial + M M M M M M M M M M M M M M M M M M M M M M M M 4

.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M + M M M M M M M M M M M M M M M M M M M 3

.........................................................................................................................................................................................................Lymph Node, Mediastinal + M + + M + + M + M + + M + + + M M + M + M M + + 36

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00405

00408

00410

00411

00414

00417

00418

00424

00425

00426

00427

00432

00435

00437

00447

00448

00401

00404

00406

00413

00421

00430

00438

00440

00443 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 41

Page 42: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Fibrous Histiocytoma, Metastatic, Skin X 1.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + M M + + + + + + + + + M M 44

Thymoma Benign X 1

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X 2.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50

Basal Cell Carcinoma 2

Keratoacanthoma X X 2

Squamous Cell Carcinoma X 1

Squamous Cell Papilloma 1

Subcutaneous Tissue, Fibroma X X X X 4

Subcutaneous Tissue, Fibrosarcoma 1

Subcutaneous Tissue, FibrousHistiocytoma

X 1

Subcutaneous Tissue, Lipoma X 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00405

00408

00410

00411

00414

00417

00418

00424

00425

00426

00427

00432

00435

00437

00447

00448

00401

00404

00406

00413

00421

00430

00438

00440

00443 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 42

Page 43: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Subcutaneous Tissue, Sarcoma X 1

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

Cranium, Osteosarcoma 1

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Pituitary Gland X 1

Osteosarcoma, Metastatic, Bone 1

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50

Alveolar/Bronchiolar Adenoma 1

Alveolar/Bronchiolar Carcinoma X 1

Pheochromocytoma Complex,Metastatic, Adrenal Medulla

1

.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00405

00408

00410

00411

00414

00417

00418

00424

00425

00426

00427

00432

00435

00437

00447

00448

00401

00404

00406

00413

00421

00430

00438

00440

00443 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 43

Page 44: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 49

Adenoma, Tubular X 1.........................................................................................................................................................................................................

Pleura + + + 3.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Zymbal's Gland 1

Carcinoma 1

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50

Cortex, Renal Tubule, Adenoma X 1.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

SYSTEMIC LESIONS

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00405

00408

00410

00411

00414

00417

00418

00424

00425

00426

00427

00432

00435

00437

00447

00448

00401

00404

00406

00413

00421

00430

00438

00440

00443 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 44

Page 45: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50

Leukemia Mononuclear X 5

Mesothelioma Malignant X 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

60 PPM

00405

00408

00410

00411

00414

00417

00418

00424

00425

00426

00427

00432

00435

00437

00447

00448

00401

00404

00406

00413

00421

00430

00438

00440

00443 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 45

Page 46: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + A + + + + +.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X

.........................................................................................................................................................................................................Intestine Small, Ileum + A + + + + + + + + + + + + + + + + + A + + + + +

.........................................................................................................................................................................................................Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + A + + + + +

.........................................................................................................................................................................................................Liver + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Mesentery + + + +

.........................................................................................................................................................................................................Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0381

0483

0484

0566

0577

0586

0614

0619

0619

0641

0647

0654

0663

0674

0687

0689

0695

0701

0703

0708

0722

0725

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00646

00642

00630

00603

00609

00629

00602

00606

00616

00648

00601

00612

00636

00634

00631

00644

00633

00627

00611

00647

00621

00619

00605

00610

00613

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 46

Page 47: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Tongue +

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel +.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +

Pheochromocytoma Benign X X X X X

.........................................................................................................................................................................................................Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X

Carcinoma X X

.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0381

0483

0484

0566

0577

0586

0614

0619

0619

0641

0647

0654

0663

0674

0687

0689

0695

0701

0703

0708

0722

0725

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00646

00642

00630

00603

00609

00629

00602

00606

00616

00648

00601

00612

00636

00634

00631

00644

00633

00627

00611

00647

00621

00619

00605

00610

00613

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 47

Page 48: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Parathyroid Gland M + + + + M + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X X X X X X X X X X X X X X X X

.........................................................................................................................................................................................................Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

C-cell, Adenoma X X

C-cell, Carcinoma

Follicular Cell, Adenoma X

Follicular Cell, Carcinoma

GENERAL BODY SYSTEM.........................................................................................................................................................................................................

Peritoneum + +

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + + I + + + + + +

Carcinoma X

.........................................................................................................................................................................................................Prostate + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0381

0483

0484

0566

0577

0586

0614

0619

0619

0641

0647

0654

0663

0674

0687

0689

0695

0701

0703

0708

0722

0725

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00646

00642

00630

00603

00609

00629

00602

00606

00616

00648

00601

00612

00636

00634

00631

00644

00633

00627

00611

00647

00621

00619

00605

00610

00613

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 48

Page 49: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + +

Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X X X

Interstitial Cell, Adenoma X X X X

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node.........................................................................................................................................................................................................

Lymph Node, Bronchial M M M M M M M M M M M M M M M M + M M M M M M M M.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + M + + + + + + + M + M + M M + + + M + + M +

Carcinoma, Metastatic, Zymbal'S Gland X

.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Thymus + + + M + + + + + + + M + + + + + + + + M + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0381

0483

0484

0566

0577

0586

0614

0619

0619

0641

0647

0654

0663

0674

0687

0689

0695

0701

0703

0708

0722

0725

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00646

00642

00630

00603

00609

00629

00602

00606

00616

00648

00601

00612

00636

00634

00631

00644

00633

00627

00611

00647

00621

00619

00605

00610

00613

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 49

Page 50: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma

Fibroadenoma.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +

Basal Cell Adenoma X

Basal Cell Carcinoma X X

Keratoacanthoma X

Squamous Cell Papilloma X

Sebaceous Gland, Adenoma

Subcutaneous Tissue, Fibroma X X X X X

Subcutaneous Tissue, Lipoma

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Zymbal'S Gland X

Cranium, Osteosarcoma X

NERVOUS SYSTEM

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0381

0483

0484

0566

0577

0586

0614

0619

0619

0641

0647

0654

0663

0674

0687

0689

0695

0701

0703

0708

0722

0725

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00646

00642

00630

00603

00609

00629

00602

00606

00616

00648

00601

00612

00636

00634

00631

00644

00633

00627

00611

00647

00621

00619

00605

00610

00613

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 50

Page 51: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Brain + + + + + + + + + + + + + + + + + + + + + + + + +

Pineal Gland, Carcinoma X

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + +

Alveolar/Bronchiolar Adenoma.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Pleura + + + +.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Zymbal's Gland +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0381

0483

0484

0566

0577

0586

0614

0619

0619

0641

0647

0654

0663

0674

0687

0689

0695

0701

0703

0708

0722

0725

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00646

00642

00630

00603

00609

00629

00602

00606

00616

00648

00601

00612

00636

00634

00631

00644

00633

00627

00611

00647

00621

00619

00605

00610

00613

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 51

Page 52: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Carcinoma X

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +

Cortex, Renal Tubule, Adenoma X X

.........................................................................................................................................................................................................Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +

Histiocytic Sarcoma X

Leukemia Mononuclear X X

Mesothelioma Malignant X X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0381

0483

0484

0566

0577

0586

0614

0619

0619

0641

0647

0654

0663

0674

0687

0689

0695

0701

0703

0708

0722

0725

0729

0729

0729

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00646

00642

00630

00603

00609

00629

00602

00606

00616

00648

00601

00612

00636

00634

00631

00644

00633

00627

00611

00647

00621

00619

00605

00610

00613

males(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 52

Page 53: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma 1.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Mesentery + + + + + + + 11.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X 1.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00614

00617

00622

00625

00638

00640

00641

00643

00649

00650

00604

00607

00608

00615

00618

00620

00623

00624

00626

00628

00632

00635

00637

00639

00645 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 53

Page 54: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50

.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50

.........................................................................................................................................................................................................Tongue 1

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel 1.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pheochromocytoma Benign X X X X 9.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma 1

Carcinoma X X 4.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00614

00617

00622

00625

00638

00640

00641

00643

00649

00650

00604

00607

00608

00615

00618

00620

00623

00624

00626

00628

00632

00635

00637

00639

00645 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 54

Page 55: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + M + + + 49

Adenoma X X X X X X X X X X X X X X X X 33.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

C-cell, Adenoma X X 4

C-cell, Carcinoma X X 2

Follicular Cell, Adenoma 1

Follicular Cell, Carcinoma X 1

GENERAL BODY SYSTEM.........................................................................................................................................................................................................

Peritoneum + 3

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49

Carcinoma X 2.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00614

00617

00622

00625

00638

00640

00641

00643

00649

00650

00604

00607

00608

00615

00618

00620

00623

00624

00626

00628

00632

00635

00637

00639

00645 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 55

Page 56: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50

Bilateral, Interstitial Cell, Adenoma X X X X X X X X X X X X X X X X X X 30

Interstitial Cell, Adenoma X X X X X X X 11

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lymph Node + 1.........................................................................................................................................................................................................

Lymph Node, Bronchial M M M M M M M M M + M M M M M M M + M M M M M M + 4.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + M M M + M M + + + + + M + M + M M M M + M 31

Carcinoma, Metastatic, Zymbal'S Gland 1.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Thymus + + + + + + + + M + + M + + + M + M + + + + + + + 43

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00614

00617

00622

00625

00638

00640

00641

00643

00649

00650

00604

00607

00608

00615

00618

00620

00623

00624

00626

00628

00632

00635

00637

00639

00645 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 56

Page 57: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X 1

Fibroadenoma X 1.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50

Basal Cell Adenoma 1

Basal Cell Carcinoma X 3

Keratoacanthoma X 2

Squamous Cell Papilloma X X X 4

Sebaceous Gland, Adenoma X X 2

Subcutaneous Tissue, Fibroma 5

Subcutaneous Tissue, Lipoma X 1

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Zymbal'S Gland 1

Cranium, Osteosarcoma 1

NERVOUS SYSTEM

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00614

00617

00622

00625

00638

00640

00641

00643

00649

00650

00604

00607

00608

00615

00618

00620

00623

00624

00626

00628

00632

00635

00637

00639

00645 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 57

Page 58: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pineal Gland, Carcinoma 1

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50

Alveolar/Bronchiolar Adenoma X X 2.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Pleura + + + + + + 10.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Zymbal's Gland 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00614

00617

00622

00625

00638

00640

00641

00643

00649

00650

00604

00607

00608

00615

00618

00620

00623

00624

00626

00628

00632

00635

00637

00639

00645 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 58

Page 59: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Carcinoma 1

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50

Cortex, Renal Tubule, Adenoma 2.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1

Leukemia Mononuclear 2

Mesothelioma Malignant X 3

*** END OF MALE DATA ***

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0729

0729

0729

0729

0729

0729

0729

0729

0729

0729

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

0730

.................................................................................................................................................................

FISCHER 344 RATS MALEANIMAL ID

120 PPM

00614

00617

00622

00625

00638

00640

00641

00643

00649

00650

00604

00607

00608

00615

00618

00620

00623

00624

00626

00628

00632

00635

00637

00639

00645 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 59

Page 60: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + A + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + A + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Mesentery + + + + +.........................................................................................................................................................................................................

Oral Mucosa +.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0038

0420

0522

0523

0582

0591

0624

0628

0648

0666

0675

0677

0680

0681

0682

0691

0697

0717

0717

0730

0730

0730

0730

0730

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00119

00106

00118

00105

00130

00111

00132

00112

00144

00140

00115

00117

00145

00148

00101

00103

00142

00120

00125

00113

00116

00123

00124

00139

00104

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 60

Page 61: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Tongue +

Squamous Cell Carcinoma X

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X

Bilateral, Adenoma X

.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +

Pheochromocytoma Benign

Pheochromocytoma Malignant.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0038

0420

0522

0523

0582

0591

0624

0628

0648

0666

0675

0677

0680

0681

0682

0691

0697

0717

0717

0730

0730

0730

0730

0730

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00119

00106

00118

00105

00130

00111

00132

00112

00144

00140

00115

00117

00145

00148

00101

00103

00142

00120

00125

00113

00116

00123

00124

00139

00104

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 61

Page 62: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Parathyroid Gland + + + + + + + + + + + + + + + M + + + + + + + + +.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + M + + + + + + + + + + +

Adenoma X X X X X X X X X X X X X X X X X X X

.........................................................................................................................................................................................................Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

C-cell, Adenoma X

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X X

.........................................................................................................................................................................................................Ovary + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Uterus + + + + + + + + + + + + + + + + + + + + + + + + +

Polyp Stromal X X X

Endometrium, Adenoma

Endometrium, Carcinoma

HEMATOPOIETIC SYSTEM

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0038

0420

0522

0523

0582

0591

0624

0628

0648

0666

0675

0677

0680

0681

0682

0691

0697

0717

0717

0730

0730

0730

0730

0730

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00119

00106

00118

00105

00130

00111

00132

00112

00144

00140

00115

00117

00145

00148

00101

00103

00142

00120

00125

00113

00116

00123

00124

00139

00104

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 62

Page 63: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Lymph Node + + +

.........................................................................................................................................................................................................Lymph Node, Bronchial M + M + M M M M M M + M M M M M M M M M M M M M M

.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M

.........................................................................................................................................................................................................Lymph Node, Mediastinal + + + + + + M + + + + + + M M + + M + + M M + + M

.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Thymus + + + + + + + + + M + + + + + + + + + + + + + + +

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X X

Fibroadenoma X X X X X

Fibroadenoma, Multiple.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0038

0420

0522

0523

0582

0591

0624

0628

0648

0666

0675

0677

0680

0681

0682

0691

0697

0717

0717

0730

0730

0730

0730

0730

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00119

00106

00118

00105

00130

00111

00132

00112

00144

00140

00115

00117

00145

00148

00101

00103

00142

00120

00125

00113

00116

00123

00124

00139

00104

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 63

Page 64: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Lip, Squamous Cell Carcinoma X

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + +

Squamous Cell Carcinoma, Metastatic,Skin

X

.........................................................................................................................................................................................................Skeletal Muscle +

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + +

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Zymbal'S Gland X

Squamous Cell Carcinoma, Metastatic,Tongue

X

.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0038

0420

0522

0523

0582

0591

0624

0628

0648

0666

0675

0677

0680

0681

0682

0691

0697

0717

0717

0730

0730

0730

0730

0730

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00119

00106

00118

00105

00130

00111

00132

00112

00144

00140

00115

00117

00145

00148

00101

00103

00142

00120

00125

00113

00116

00123

00124

00139

00104

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 64

Page 65: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Pleura + + + +

.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + I + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Zymbal's Gland +

Carcinoma X

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +

Histiocytic Sarcoma X X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0038

0420

0522

0523

0582

0591

0624

0628

0648

0666

0675

0677

0680

0681

0682

0691

0697

0717

0717

0730

0730

0730

0730

0730

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00119

00106

00118

00105

00130

00111

00132

00112

00144

00140

00115

00117

00145

00148

00101

00103

00142

00120

00125

00113

00116

00123

00124

00139

00104

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 65

Page 66: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Leukemia Mononuclear X X X X X X X X X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0038

0420

0522

0523

0582

0591

0624

0628

0648

0666

0675

0677

0680

0681

0682

0691

0697

0717

0717

0730

0730

0730

0730

0730

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00119

00106

00118

00105

00130

00111

00132

00112

00144

00140

00115

00117

00145

00148

00101

00103

00142

00120

00125

00113

00116

00123

00124

00139

00104

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 66

Page 67: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Mesentery + + + + + 10.........................................................................................................................................................................................................

Oral Mucosa 1.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00107

00110

00114

00121

00126

00128

00133

00134

00135

00136

00137

00141

00143

00147

00149

00102

00108

00109

00122

00127

00129

00131

00138

00146

00150 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 67

Page 68: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50

.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50

.........................................................................................................................................................................................................Tongue 1

Squamous Cell Carcinoma 1

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X X X X 7

Bilateral, Adenoma 1.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pheochromocytoma Benign X X 2

Pheochromocytoma Malignant X 1.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00107

00110

00114

00121

00126

00128

00133

00134

00135

00136

00137

00141

00143

00147

00149

00102

00108

00109

00122

00127

00129

00131

00138

00146

00150 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 68

Page 69: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49

Adenoma X X X X X X X X X X X X X X X X X 36.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

C-cell, Adenoma X X 3

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X X 4.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50

Polyp Stromal X X X 6

Endometrium, Adenoma X 1

Endometrium, Carcinoma X 1

HEMATOPOIETIC SYSTEM

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00107

00110

00114

00121

00126

00128

00133

00134

00135

00136

00137

00141

00143

00147

00149

00102

00108

00109

00122

00127

00129

00131

00138

00146

00150 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 69

Page 70: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50

.........................................................................................................................................................................................................Lymph Node + 4

.........................................................................................................................................................................................................Lymph Node, Bronchial M M M M M M M M M M M M M M M M M M M M M M M M M 3

.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0

.........................................................................................................................................................................................................Lymph Node, Mediastinal M + M + M M + + M M + + + + M + M + M M + + + + + 33

.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50

.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50

.........................................................................................................................................................................................................Thymus + + M + + + + + M M + + + + + + + + M + + + + M + 44

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X 3

Fibroadenoma X X X X X X X X 13

Fibroadenoma, Multiple X 1.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00107

00110

00114

00121

00126

00128

00133

00134

00135

00136

00137

00141

00143

00147

00149

00102

00108

00109

00122

00127

00129

00131

00138

00146

00150 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 70

Page 71: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Lip, Squamous Cell Carcinoma 1

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

Squamous Cell Carcinoma, Metastatic,Skin

1

.........................................................................................................................................................................................................Skeletal Muscle 1

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Zymbal'S Gland 1

Squamous Cell Carcinoma, Metastatic,Tongue

1

.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00107

00110

00114

00121

00126

00128

00133

00134

00135

00136

00137

00141

00143

00147

00149

00102

00108

00109

00122

00127

00129

00131

00138

00146

00150 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 71

Page 72: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Pleura + + + + + 9

.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Zymbal's Gland 1

Carcinoma 1

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 2

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00107

00110

00114

00121

00126

00128

00133

00134

00135

00136

00137

00141

00143

00147

00149

00102

00108

00109

00122

00127

00129

00131

00138

00146

00150 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 72

Page 73: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Leukemia Mononuclear X X X X X X X X 17

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

CONTROL

00107

00110

00114

00121

00126

00128

00133

00134

00135

00136

00137

00141

00143

00147

00149

00102

00108

00109

00122

00127

00129

00131

00138

00146

00150 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 73

Page 74: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +

Polyp Adenomatous.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Mesentery + + + + + + + + +.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0196

0438

0474

0516

0528

0556

0644

0651

0680

0699

0703

0708

0712

0725

0730

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00333

00307

00329

00312

00342

00302

00335

00334

00314

00350

00322

00344

00323

00301

00317

00324

00326

00337

00338

00343

00304

00305

00309

00310

00311

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 74

Page 75: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Tongue

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X

.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +

Pheochromocytoma Benign.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma

Carcinoma.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0196

0438

0474

0516

0528

0556

0644

0651

0680

0699

0703

0708

0712

0725

0730

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00333

00307

00329

00312

00342

00302

00335

00334

00314

00350

00322

00344

00323

00301

00317

00324

00326

00337

00338

00343

00304

00305

00309

00310

00311

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 75

Page 76: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X X X X X X X X X X X X X

Carcinoma X

.........................................................................................................................................................................................................Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

C-cell, Adenoma X

C-cell, Carcinoma X

Follicular Cell, Adenoma

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +

Granulosa Cell Tumor Malignant.........................................................................................................................................................................................................

Oviduct.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +

Leiomyosarcoma

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0196

0438

0474

0516

0528

0556

0644

0651

0680

0699

0703

0708

0712

0725

0730

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00333

00307

00329

00312

00342

00302

00335

00334

00314

00350

00322

00344

00323

00301

00317

00324

00326

00337

00338

00343

00304

00305

00309

00310

00311

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 76

Page 77: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Polyp Stromal X X X X X

Sarcoma Stromal

Bilateral, Polyp Stromal X

Endometrium, Carcinoma

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node + +.........................................................................................................................................................................................................

Lymph Node, Bronchial M M M M M M M M M M M M + M M M M M M M M M M + M.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + M + M + M + + + + + + + + M + + + + + +.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +

Osteosarcoma.........................................................................................................................................................................................................

Thymus + + M + + + + M + + + + + + + + + + + M + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0196

0438

0474

0516

0528

0556

0644

0651

0680

0699

0703

0708

0712

0725

0730

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00333

00307

00329

00312

00342

00302

00335

00334

00314

00350

00322

00344

00323

00301

00317

00324

00326

00337

00338

00343

00304

00305

00309

00310

00311

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 77

Page 78: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X

Fibroadenoma X X X X X X X X X

Fibroadenoma, Multiple X X X

.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +

Basal Cell Carcinoma X

Keratoacanthoma X X

Subcutaneous Tissue, Fibroma X

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skeletal Muscle +

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Peripheral Nerve +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0196

0438

0474

0516

0528

0556

0644

0651

0680

0699

0703

0708

0712

0725

0730

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00333

00307

00329

00312

00342

00302

00335

00334

00314

00350

00322

00344

00323

00301

00317

00324

00326

00337

00338

00343

00304

00305

00309

00310

00311

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 78

Page 79: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Spinal Cord +

Oligodendroglioma Malignant X

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + +

Sarcoma, Metastatic, Uncertain PrimarySite

X

.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +

Respiratory Epithelium, Turbinate,Adenoma

.........................................................................................................................................................................................................Pleura + + + +

.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0196

0438

0474

0516

0528

0556

0644

0651

0680

0699

0703

0708

0712

0725

0730

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00333

00307

00329

00312

00342

00302

00335

00334

00314

00350

00322

00344

00323

00301

00317

00324

00326

00337

00338

00343

00304

00305

00309

00310

00311

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 79

Page 80: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +

Transitional Epithelium, Papilloma

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +

Histiocytic Sarcoma X X

Leukemia Mononuclear X X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0196

0438

0474

0516

0528

0556

0644

0651

0680

0699

0703

0708

0712

0725

0730

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00333

00307

00329

00312

00342

00302

00335

00334

00314

00350

00322

00344

00323

00301

00317

00324

00326

00337

00338

00343

00304

00305

00309

00310

00311

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 80

Page 81: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50

Polyp Adenomatous X 1.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Mesentery + + + + + + + + + 18.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00313

00318

00320

00321

00325

00328

00330

00331

00336

00339

00340

00345

00346

00303

00306

00308

00315

00316

00319

00327

00332

00341

00347

00348

00349 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 81

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Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Tongue + 1

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X X 5.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pheochromocytoma Benign X 1.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X 1

Carcinoma X 1.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00313

00318

00320

00321

00325

00328

00330

00331

00336

00339

00340

00345

00346

00303

00306

00308

00315

00316

00319

00327

00332

00341

00347

00348

00349 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 82

Page 83: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X X X X X X X X X X X X X X 29

Carcinoma 1.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

C-cell, Adenoma X X 3

C-cell, Carcinoma X 2

Follicular Cell, Adenoma X 1

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X X 2.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50

Granulosa Cell Tumor Malignant X 1.........................................................................................................................................................................................................

Oviduct + 1.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50

Leiomyosarcoma X 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00313

00318

00320

00321

00325

00328

00330

00331

00336

00339

00340

00345

00346

00303

00306

00308

00315

00316

00319

00327

00332

00341

00347

00348

00349 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 83

Page 84: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Polyp Stromal X X X 8

Sarcoma Stromal X 1

Bilateral, Polyp Stromal X 2

Endometrium, Carcinoma X 1

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lymph Node + 3.........................................................................................................................................................................................................

Lymph Node, Bronchial + M M M M M M M M M M M + M M M + M M M M M M M M 5.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + M M M M M M + + + + + + M + M + + + + M M 36.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50

Osteosarcoma X 1.........................................................................................................................................................................................................

Thymus + + + + + M + + + M + + + + + + + + + + + + + + + 45

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00313

00318

00320

00321

00325

00328

00330

00331

00336

00339

00340

00345

00346

00303

00306

00308

00315

00316

00319

00327

00332

00341

00347

00348

00349 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 84

Page 85: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X X 3

Fibroadenoma X X X X X 14

Fibroadenoma, Multiple X X X X X X 9.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50

Basal Cell Carcinoma X 2

Keratoacanthoma 2

Subcutaneous Tissue, Fibroma 1

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Skeletal Muscle 1

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Peripheral Nerve 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00313

00318

00320

00321

00325

00328

00330

00331

00336

00339

00340

00345

00346

00303

00306

00308

00315

00316

00319

00327

00332

00341

00347

00348

00349 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 85

Page 86: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Spinal Cord 1

Oligodendroglioma Malignant 1

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50

Sarcoma, Metastatic, Uncertain PrimarySite

1

.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50

Respiratory Epithelium, Turbinate,Adenoma

X 1

.........................................................................................................................................................................................................Pleura + + + + + + + + + + + + 16

.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00313

00318

00320

00321

00325

00328

00330

00331

00336

00339

00340

00345

00346

00303

00306

00308

00315

00316

00319

00327

00332

00341

00347

00348

00349 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 86

Page 87: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

Transitional Epithelium, Papilloma X 1

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 2

Leukemia Mononuclear 2

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

30 PPM

00313

00318

00320

00321

00325

00328

00330

00331

00336

00339

00340

00345

00346

00303

00306

00308

00315

00316

00319

00327

00332

00341

00347

00348

00349 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 87

Page 88: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + A + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum + + A + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Jejunum + + A + + + + + + + + + + + + A + A + + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +

Fibrous Histiocytoma X

Fibrous Histiocytoma, Metastatic, Skin X

Hepatocellular Carcinoma.........................................................................................................................................................................................................

Mesentery + + + + + +.........................................................................................................................................................................................................

Oral Mucosa.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0425

0509

0515

0528

0591

0607

0614

0627

0631

0641

0663

0685

0704

0704

0708

0715

0717

0723

0727

0730

0730

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00524

00543

00539

00515

00530

00520

00510

00536

00522

00516

00541

00547

00501

00517

00538

00550

00506

00509

00531

00518

00521

00502

00504

00505

00508

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 88

Page 89: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +

Epithelium, Adenoma X

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma

Fibrous Histiocytoma, Metastatic, Skin X

Bilateral, Adenoma X

.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +

Pheochromocytoma Malignant.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0425

0509

0515

0528

0591

0607

0614

0627

0631

0641

0663

0685

0704

0704

0708

0715

0717

0723

0727

0730

0730

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00524

00543

00539

00515

00530

00520

00510

00536

00522

00516

00541

00547

00501

00517

00538

00550

00506

00509

00531

00518

00521

00502

00504

00505

00508

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 89

Page 90: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Adenoma X

.........................................................................................................................................................................................................Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X X X X X X X X X X X X X X X X X

Carcinoma.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +

C-cell, Adenoma X X

Follicular Cell, Carcinoma

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X X

.........................................................................................................................................................................................................Ovary + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Uterus + + + + + + + + + + + + + + + + + + + + + + + + +

Polyp Stromal X X X X X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0425

0509

0515

0528

0591

0607

0614

0627

0631

0641

0663

0685

0704

0704

0708

0715

0717

0723

0727

0730

0730

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00524

00543

00539

00515

00530

00520

00510

00536

00522

00516

00541

00547

00501

00517

00538

00550

00506

00509

00531

00518

00521

00502

00504

00505

00508

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 90

Page 91: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Sarcoma Stromal X

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node +

Renal, Stromal Nephroma, Metastatic,Kidney

X

.........................................................................................................................................................................................................Lymph Node, Bronchial M M M + M M M M M M M M M M M M M M M M M M M M M

.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M

.........................................................................................................................................................................................................Lymph Node, Mediastinal + + + + M + + + + + + + + + M + + + M + + M + + +

Fibrous Histiocytoma, Metastatic, Skin X

.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + +

Fibrous Histiocytoma, Metastatic, Skin X

.........................................................................................................................................................................................................Thymus + + + + M + + + + + + + + + + + + M + + + + + + +

Thymoma Benign X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0425

0509

0515

0528

0591

0607

0614

0627

0631

0641

0663

0685

0704

0704

0708

0715

0717

0723

0727

0730

0730

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00524

00543

00539

00515

00530

00520

00510

00536

00522

00516

00541

00547

00501

00517

00538

00550

00506

00509

00531

00518

00521

00502

00504

00505

00508

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 91

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INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X X X

Fibroadenoma X X X X X X X X X

Fibroadenoma, Multiple X X X

.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +

Fibrous Histiocytoma X

Subcutaneous Tissue, FibrousHistiocytoma

X

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + +

Rib, Osteosarcoma X

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + +

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0425

0509

0515

0528

0591

0607

0614

0627

0631

0641

0663

0685

0704

0704

0708

0715

0717

0723

0727

0730

0730

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00524

00543

00539

00515

00530

00520

00510

00536

00522

00516

00541

00547

00501

00517

00538

00550

00506

00509

00531

00518

00521

00502

00504

00505

00508

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 92

Page 93: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + +

Fibrous Histiocytoma, Metastatic, Skin X

Osteosarcoma, Metastatic, Bone X

Stromal Nephroma, Metastatic, Kidney X

.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Pleura + + + + + +

.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + I + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +

Fibrous Histiocytoma, Metastatic, Skin X

Nephroblastoma X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0425

0509

0515

0528

0591

0607

0614

0627

0631

0641

0663

0685

0704

0704

0708

0715

0717

0723

0727

0730

0730

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00524

00543

00539

00515

00530

00520

00510

00536

00522

00516

00541

00547

00501

00517

00538

00550

00506

00509

00531

00518

00521

00502

00504

00505

00508

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 93

Page 94: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +

Histiocytic Sarcoma X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0425

0509

0515

0528

0591

0607

0614

0627

0631

0641

0663

0685

0704

0704

0708

0715

0717

0723

0727

0730

0730

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00524

00543

00539

00515

00530

00520

00510

00536

00522

00516

00541

00547

00501

00517

00538

00550

00506

00509

00531

00518

00521

00502

00504

00505

00508

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 94

Page 95: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 48.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50

Fibrous Histiocytoma 1

Fibrous Histiocytoma, Metastatic, Skin 1

Hepatocellular Carcinoma X 1.........................................................................................................................................................................................................

Mesentery + + + + + + + + + + + + 18.........................................................................................................................................................................................................

Oral Mucosa + 1.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00511

00512

00519

00525

00526

00527

00529

00546

00549

00503

00507

00513

00514

00523

00528

00532

00533

00534

00535

00537

00540

00542

00544

00545

00548 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 95

Page 96: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50

Epithelium, Adenoma 1

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X X X 4

Fibrous Histiocytoma, Metastatic, Skin 1

Bilateral, Adenoma 1.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pheochromocytoma Malignant X 1.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00511

00512

00519

00525

00526

00527

00529

00546

00549

00503

00507

00513

00514

00523

00528

00532

00533

00534

00535

00537

00540

00542

00544

00545

00548 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 96

Page 97: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Adenoma 1.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + + + + + M + + + + M + + + + + + 48.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X X X X X X X X X X X X X 32

Carcinoma X 1.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

C-cell, Adenoma X X 4

Follicular Cell, Carcinoma X 1

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X 3.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50

Polyp Stromal X X X X 9

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00511

00512

00519

00525

00526

00527

00529

00546

00549

00503

00507

00513

00514

00523

00528

00532

00533

00534

00535

00537

00540

00542

00544

00545

00548 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 97

Page 98: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Sarcoma Stromal 1

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lymph Node + + 3

Renal, Stromal Nephroma, Metastatic,Kidney

1

.........................................................................................................................................................................................................Lymph Node, Bronchial M M M M M + M M M + M M M M M M M M M M M M M M M 3

.........................................................................................................................................................................................................Lymph Node, Mandibular M M + M M M M M M M M M M M M M M M M M M M M M M 1

.........................................................................................................................................................................................................Lymph Node, Mediastinal + + M + + M M + + + M + + + + + + + M + + + + + M 40

Fibrous Histiocytoma, Metastatic, Skin 1.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50

Fibrous Histiocytoma, Metastatic, Skin 1.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 48

Thymoma Benign 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00511

00512

00519

00525

00526

00527

00529

00546

00549

00503

00507

00513

00514

00523

00528

00532

00533

00534

00535

00537

00540

00542

00544

00545

00548 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 98

Page 99: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X X 5

Fibroadenoma X X X X X X X X X X 19

Fibroadenoma, Multiple X 4.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50

Fibrous Histiocytoma 1

Subcutaneous Tissue, FibrousHistiocytoma

1

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

Rib, Osteosarcoma 1

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00511

00512

00519

00525

00526

00527

00529

00546

00549

00503

00507

00513

00514

00523

00528

00532

00533

00534

00535

00537

00540

00542

00544

00545

00548 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 99

Page 100: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50

Fibrous Histiocytoma, Metastatic, Skin 1

Osteosarcoma, Metastatic, Bone 1

Stromal Nephroma, Metastatic, Kidney 1.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Pleura + + + + + + + + + 15.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50

Fibrous Histiocytoma, Metastatic, Skin 1

Nephroblastoma 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00511

00512

00519

00525

00526

00527

00529

00546

00549

00503

00507

00513

00514

00523

00528

00532

00533

00534

00535

00537

00540

00542

00544

00545

00548 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 100

Page 101: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

60 PPM

00511

00512

00519

00525

00526

00527

00529

00546

00549

00503

00507

00513

00514

00523

00528

00532

00533

00534

00535

00537

00540

00542

00544

00545

00548 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 101

Page 102: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + A + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Kidney X

Hepatocellular Adenoma X X

Hepatocellular Carcinoma X

.........................................................................................................................................................................................................Mesentery + + + + + +

.........................................................................................................................................................................................................Oral Mucosa

.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0442

0488

0563

0645

0647

0648

0670

0681

0685

0694

0703

0703

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00702

00738

00731

00723

00721

00742

00729

00714

00732

00735

00703

00739

00708

00711

00713

00737

00744

00706

00707

00709

00710

00712

00715

00716

00717

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 102

Page 103: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Tongue +

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Kidney X

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X X X X X X X

.........................................................................................................................................................................................................Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Kidney X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0442

0488

0563

0645

0647

0648

0670

0681

0685

0694

0703

0703

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00702

00738

00731

00723

00721

00742

00729

00714

00732

00735

00703

00739

00708

00711

00713

00737

00744

00706

00707

00709

00710

00712

00715

00716

00717

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 103

Page 104: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Pheochromocytoma Benign

Pheochromocytoma Malignant.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Parathyroid Gland + M + M + + + + + + + + + + + + + + + + + M + + +.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X X X X X X X X X X X X X X X X X X X

Carcinoma.........................................................................................................................................................................................................

Thyroid Gland + + + M + + + + + + + + + + + + + + + + + + + + +

C-cell, Adenoma X X X X

C-cell, Carcinoma X

Follicular Cell, Carcinoma X

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Adenoma X

Carcinoma X X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0442

0488

0563

0645

0647

0648

0670

0681

0685

0694

0703

0703

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00702

00738

00731

00723

00721

00742

00729

00714

00732

00735

00703

00739

00708

00711

00713

00737

00744

00706

00707

00709

00710

00712

00715

00716

00717

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 104

Page 105: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Ovary + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Kidney X

Granulosa Cell Tumor Benign

Granulosa Cell Tumor Malignant X

.........................................................................................................................................................................................................Uterus + + + + + + + + + + + + + + + + + + + + + + + + +

Polyp Stromal X X X X X X

.........................................................................................................................................................................................................Vagina

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node + +.........................................................................................................................................................................................................

Lymph Node, Bronchial + M M M M M M M M M + M M M M M M M M M M M M M M

Carcinoma, Metastatic, Kidney X

.........................................................................................................................................................................................................Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M

.........................................................................................................................................................................................................Lymph Node, Mediastinal + + + + + + + + M + + M + M M M + M + M + + + + +

.........................................................................................................................................................................................................Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0442

0488

0563

0645

0647

0648

0670

0681

0685

0694

0703

0703

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00702

00738

00731

00723

00721

00742

00729

00714

00732

00735

00703

00739

00708

00711

00713

00737

00744

00706

00707

00709

00710

00712

00715

00716

00717

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 105

Page 106: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Kidney X

.........................................................................................................................................................................................................Thymus M + + + + + + + + + + + + M + + + + + + + + + + +

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X X X

Fibroadenoma X X X X X X X

Fibroadenoma, Multiple X

.........................................................................................................................................................................................................Skin + + + + + + + + + + + + + + + + + + + + + + + + +

Basal Cell Carcinoma

Keratoacanthoma

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0442

0488

0563

0645

0647

0648

0670

0681

0685

0694

0703

0703

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00702

00738

00731

00723

00721

00742

00729

00714

00732

00735

00703

00739

00708

00711

00713

00737

00744

00706

00707

00709

00710

00712

00715

00716

00717

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 106

Page 107: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Brain + + + + + + + + + + + + + + + + + + + + + + + + +

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma, Metastatic, Kidney X

.........................................................................................................................................................................................................Nose + + + + + + + + + + + + + + + + + + + + + + + + +

.........................................................................................................................................................................................................Pleura + + + + + + + +

Carcinoma, Metastatic, Kidney X

.........................................................................................................................................................................................................Trachea + + + + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0442

0488

0563

0645

0647

0648

0670

0681

0685

0694

0703

0703

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00702

00738

00731

00723

00721

00742

00729

00714

00732

00735

00703

00739

00708

00711

00713

00737

00744

00706

00707

00709

00710

00712

00715

00716

00717

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 107

Page 108: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +

Carcinoma X

Cortex, Renal Tubule, Adenoma X

.........................................................................................................................................................................................................Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +

Histiocytic Sarcoma

Leukemia Mononuclear X X X

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0442

0488

0563

0645

0647

0648

0670

0681

0685

0694

0703

0703

0730

0730

0730

0730

0730

0731

0731

0731

0731

0731

0731

0731

0731

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00702

00738

00731

00723

00721

00742

00729

00714

00732

00735

00703

00739

00708

00711

00713

00737

00744

00706

00707

00709

00710

00712

00715

00716

00717

females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 108

Page 109: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 49.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Kidney 1

Hepatocellular Adenoma X 3

Hepatocellular Carcinoma 1.........................................................................................................................................................................................................

Mesentery + + + + + + + + 14.........................................................................................................................................................................................................

Oral Mucosa + 1.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00724

00733

00736

00740

00741

00743

00745

00747

00749

00701

00704

00705

00718

00719

00720

00722

00725

00726

00727

00728

00730

00734

00746

00748

00750 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 109

Page 110: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Tongue + + 3

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel + 1.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Kidney 1

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X X X X 13.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Kidney 1

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00724

00733

00736

00740

00741

00743

00745

00747

00749

00701

00704

00705

00718

00719

00720

00722

00725

00726

00727

00728

00730

00734

00746

00748

00750 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 110

Page 111: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Pheochromocytoma Benign X 1

Pheochromocytoma Malignant X 1.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 47.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma X X X X X X X X X X X X X X X X X X 37

Carcinoma X 1.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49

C-cell, Adenoma X 5

C-cell, Carcinoma 1

Follicular Cell, Carcinoma 1

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Adenoma 1

Carcinoma X X 4

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00724

00733

00736

00740

00741

00743

00745

00747

00749

00701

00704

00705

00718

00719

00720

00722

00725

00726

00727

00728

00730

00734

00746

00748

00750 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 111

Page 112: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Kidney 1

Granulosa Cell Tumor Benign X 1

Granulosa Cell Tumor Malignant 1.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50

Polyp Stromal X X X X X X X X X X X 17.........................................................................................................................................................................................................

Vagina + 1

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lymph Node + 3.........................................................................................................................................................................................................

Lymph Node, Bronchial M M M M M M M M M M M M M M M M M M M M M M M M M 2

Carcinoma, Metastatic, Kidney 1.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M M M M M M 0.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + M + + + + + + + M M M M M M + M + + + M + + 34.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00724

00733

00736

00740

00741

00743

00745

00747

00749

00701

00704

00705

00718

00719

00720

00722

00725

00726

00727

00728

00730

00734

00746

00748

00750 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 112

Page 113: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

.........................................................................................................................................................................................................Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Kidney 1.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + M + + + + + + + + + M + + 46

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma X 4

Fibroadenoma X X X X 11

Fibroadenoma, Multiple X X X X 5.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50

Basal Cell Carcinoma X 1

Keratoacanthoma X 1

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

NERVOUS SYSTEM.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00724

00733

00736

00740

00741

00743

00745

00747

00749

00701

00704

00705

00718

00719

00720

00722

00725

00726

00727

00728

00730

00734

00746

00748

00750 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 113

Page 114: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma, Metastatic, Kidney 1.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Pleura + + + + + + + + + 17

Carcinoma, Metastatic, Kidney 1.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

URINARY SYSTEM.........................................................................................................................................................................................................

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00724

00733

00736

00740

00741

00743

00745

00747

00749

00701

00704

00705

00718

00719

00720

00722

00725

00726

00727

00728

00730

00734

00746

00748

00750 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 114

Page 115: ntp.niehs.nih.gov · TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009 Test Type: CHRONIC Tetralin Time Report

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50

Carcinoma 1

Cortex, Renal Tubule, Adenoma 1.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 1

Leukemia Mononuclear X 4

*** END OF REPORT ***

TDMS No. 93025 - 07 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 08/07/2009

Test Type: CHRONIC Tetralin Time Report Requested: 08:53:47

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 119-64-2 First Dose M/F: 06/16/03 / 06/16/03

Species/Strain: RATS/F 344/N Lab: BNW

DAY ON TEST0731

0731

0731

0731

0731

0731

0731

0731

0731

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

0732

.................................................................................................................................................................

FISCHER 344 RATS FEMALEANIMAL ID

120 PPM

00724

00733

00736

00740

00741

00743

00745

00747

00749

00701

00704

00705

00718

00719

00720

00722

00725

00726

00727

00728

00730

00734

00746

00748

00750 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 115