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Novost za lajšanje
• Proktitisa• Analnih razjed• Hemoroidov
Ozon reagira z dvojnimi vezmi oleinske kisline in tvori stabilne ozonide z vitamin E acetatom
Pri stiku s kožo in sluznico stabilni ozonidi razvijejo delno bio-perokside in delno molekularni kisikdevelop partially in Bio-peroxides and Molecular Oxygen
Without drug more than a drugas prevention as therapy
INDICATIONSFor topical use in the treatment of proctitis, anal
�ssures, haemorrhoids, ulcerative proctocolitis.It repairs damages caused by radiation and it acts
against in�ammation, redness, itching, burning and swelling. It has a lubricant and protective
action and stimulates tissue regenerationand re-epithelialization
HOW TO USEThoroughly cleanse the a�ected area with
diluted in water and then dry your skin.
In case of proctitis: tighten on the tube the rectal nozzle and apply to the a�ected area at night, in the
morning and after each evacuation until the condition is controlled. In case of anal �ssures and
hemorrhoids: apply the product directly on the a�ected area. The treatment period di�ers according
to the rapidity of the therapeutic response
BIBLIOGRAPHY Nathália R. de Almeida, Adilson Beatriz, Ana Camila Micheletti and Eduardo J. De Arruda, Ozonized vegetable oils and therapeutic properties: A review. Orbital, The Electronic Journal Of Chemistry, Volume 4, Number 4, October-December 2012V. Travagli, I. Zanardi, G. Valacchi, and V. Bocci, Ozone and Ozonated Oils in Skin Diseases. Mediator of In�ammation, Volume 2010 (2010), Article ID 610418V. Travagli, I. Zanardi, V. Bocci, Topical applications of ozone and ozonated oils as anti-infective agents: an insight into the patent claims. Recent Patents on Anti-Infective Drug Discovery, Volume 4, Number 2, June 2009, pp. 130-142(13)Kim HS, Noh SU, Han YW, Kim KM, Kang H, Kim HO, Park YM, Therapeutic e�ects of topical application of ozone on acute cutaneous wound healing. J Korean Med Sci, 12 June 2009 Ana del Rosario Barroetabeña Reyes, Alejandro Sánchez Anta, Juan Guerra Miranda, Acción del aceite ozonizado sobre el proceso in�amatorio en heridas de piel de animales de experimentación. Correo Cientí�co Médico de Holguín 2002Gri�n N, Zimmermann DD, Briel JW, Gruss HJ, Jonas M, Acheson AG, Neal K, Schole�eld JH, Schouten WR, Topical L-arginine gel lowers resting anal pressure: possible treatment for anal �ssure. Dis Colon Rectum. 2002 Oct; 45 (10): 1332-6Matsumoto, Akiyo; Shotaro Sakurai; Nariko Shinriki; Shigeru Suzuki & Toshiaki Miura, Therapeutic E�ects of Ozonized Olive Oil in the Treatment of Intractable Fistula and Wound after Surgical Operation. Japan, J. Clin. Surg., 61(6) 7-13 (2000)
z
Pozitivno vpliva tudi na poškodovano tkivo zaradi radioterapije
OZOILE®
ERBAGIL PATENT Stabilni Ozonidi z Vitamin E acetatom
Cleansing detergentCleansing detergent
100% MADE IN ITALYCerti�ed
Management SystemCerti�ed
Management SystemACCREDIA
Italian National Accreditation Body
100%
MA
DE
IN ITALY CERTIFI CATE
IT PI
UNI ENI ISO 13485:2012 UNI ENI ISO 9001:2008
Network
KREMA
Uvoznik in distributer: Z PHARM d.o.o., Dunajska cesta 181,1000 Ljubljana 040 457 767, www.z-pharm.si , [email protected]
Stabilni ozonidi spodbujajo regulacijo vnetnih citokinov in interlevkinov tako v akutni kot v kronični fazi. Zmanjšajo prostaglandine, ki zavirajo COX in zmanjšujejo nivoje serotonina in histamina, aktivirajo MAO in DAO katabolne
encime. V povezavi z gliciretinsko kislino in s kortizonom podobnim delovanjem črnega ribeza, imajo močan proti vnetni, analgetični učinek in delujejo proti srbenju.
Obnavlja poškodovano tkivoStabilni ozonidi prenašajo kisik v celice. Kisik, ki je takoj na voljo, aktivira
mitohondrije, kar pospešuje proizvodnjo ATP. Ta proces spodbuja regeneracijo tkiva.
The Nitric Oxide produced by the Arginine cellular Metabolism, in synergy with �avonoids of Ribes Nigrumwith phlebotonic and vasoprotective action, regulates the relaxation of the internal anal sphincter.
Reduction of anal pressure at rest
Zmanjša vnetja, otekline, srbenje in bolečino
ERBAGILVia L. Settembrini, 13 Telese Terme (Bn) - Italy
Tel. 0824.865004Fax 0824.865004
www.erbagil.com [email protected]
HemorrhoisRelaxation of the internal anal sphincter
MAO and DAOCatabolic anzymes
Histamine and SerotonineProstaglandin
COXAnabolic enzymes
Pain Redness Itching
+-
Stable Ozonides
Anti-in�ammatory action Proctitis
RhagadesCellular Oxygenation
Stable Ozonides
ATP
oo
oo
oo
oo
oo
The bio-peroxides act as bio-oxidant on bacteria, fungi and viruses Melaleuca Alternifolia Leaf Oil enhances the antifungal action of ,
Cera Alba has a barrier protective e�ect against external bacterial contamination
It protects against bacterial, viral, fungal infections
Bactericidal and fungicide action Virustatic action
impedes the recognition target cell-virus
The muscle tissue of arteryrelaxes and causes vasodilation through the action of NO
Arginine
Nitric Oxide
stimulates the production of growth factors (PDGF, TGF-b, VEGF, EGF) involved in tissue repair by inducing the proliferation of �broblasts, the synthesis of collagen and the
synthesis of new blood vessels in association with Sodium Hyaluronate
and Cera Alba regenerates the tissues and stimulates the healing process.
Stimulation of growth factors involved in tissue repair
EGFEpidermal
growth factor
TGFTransformation
and growth factor
FGFFibroblasts
growth factors
VEGFEndothelial
growth factor
PDGFGrowth factor derived
from the platelets
OZOILE®
Stable Ozonideswith Vitamin E acetate
ERBAGIL PATENT
zargininom, gliciretinsko kislino, natrijevim hialuronatom, črnim
ribezom, čebeljim voskom
Proktitis, analne razjede, hemoroidi
Ne zdravite simptoma,ampak obnovite funkcijo
OZOILE®
ERBAGIL PATENT Stabilni Ozonidi z Vitamin E acetatom
100% MADE IN ITALYCerti�ed
Management SystemCerti�ed
Management SystemACCREDIA
Italian National Accreditation Body
100%
MA
DE
IN ITALY CERTIFI CATE
IT PI
UNI ENI ISO 13485:2012 UNI ENI ISO 9001:2008
Network
KREMA
The stable Ozonides stimulate the regulation of pro-in�ammatory cytokines and interleukins both in the acute and in the chronic phase. They reduce the Prostaglandins inhibiting the COX and they reduce the serotonin and histamine levels activating the MAO
and DAO catabolic enzymes. In association with the Glycyrrhetinic Acid and with the cortison-like action of Ribes Nigrum, they have a powerful anti in�ammatory, analgesic and anti-itching e�ect.
The stable Ozonides convey oxygen to the cells. The oxygen, immediately available, activates the mithocondria accelerating the ATP production. This process stimulates the tissue regeneration.
Zmanjšanje analnega pritiska v mirovanjuDušikov oksid, ki ga proizvede argininov celični metabolizem, v sinergiji s flavonoidi črnega ribeza
s flebotonskim in žilno-zaščitnim delovanjem, uravnava sproščanje notranjega analnega sfinktra.
It regenerates damaged tissues
It reduces in�ammation, swelling, itching and pain
HemorrhoisRelaxation of the internal anal sphincter
MAO and DAOCatabolic anzymes
Histamine and SerotonineProstaglandin
COXAnabolic enzymes
Pain Redness Itching
+-
Stable Ozonides
Anti-in�ammatory action Proctitis
RhagadesCellular Oxygenation
Stable Ozonides
ATP
oo
oo
oo
oo
oo
Bi o-peroksidi delujejo kot bio-oksidant na bakterije, glive in viruse eterično olje listov čajevca ojačuje protiglivično delovanje OZOILA,
čebelji vosek ima zaščitni učinek pred zunanjimi bakterijskimi okužbami
Ščiti pred bakterijskimi, virusnimi, glivičnimi okužbami
Bactericidal and fungicide action Virustatic action
impedes the recognition target cell-virus
The muscle tissue of arteryrelaxes and causes vasodilation through the action of NO
Arginine
Nitric Oxide
stimulira proizvodnjo rastnih faktorjev (PDGF,TGF-B,VEGF,EGF), ki so vpleteni v obnovo tkiva z indukcijo proliferacije fibroblastov, sinteze kolagena in sinteze novih krvnih žil.
v povezavi z natrijevim hialuronatom in čebeljim voskom obnavlja tkiva in pospešuje proces celjenja.
Stimulacija rastnih faktorjev je zelo pomembna pri obnovi tkiv
EGFEpidermal
growth factor
TGFTransformation
and growth factor
FGFFibroblasts
growth factors
VEGFEndothelial
growth factor
PDGFGrowth factor derived
from the platelets
OZOILE®
Stable Ozonides with Vitamin E acetate
ERBAGIL PATENT
Arginine, Glycyrrhetinic Acid, Sodium Hyaluronate,Ribes Nigrum, Cera Alba
with
Proctitis, Rhagades, Hemorrhoids
Not a symptom to be curedbut a function to be restored
OZOILE®
Stable Ozonideswith Vitamin E acetate
ERBAGIL PATENT
100% MADE IN ITALYCerti�ed
Management SystemCerti�ed
Management SystemACCREDIA
Italian National Accreditation Body
100%
MA
DE
IN ITALY CERTIFI CATE
IT PI
UNI ENI ISO 13485:2012 UNI ENI ISO 9001:2008
Network
Uvoznik in distributer: Z PHARM d.o.o., Dunajska cesta 181,1000 Ljubljana 040 457 767, www.z-pharm.si , [email protected]
Topical innovationin the treatment of: • Proctitis• Anal fissures• Hemorrhoids
ERBAGILVia L. Settembrini, 13 Telese Terme (Bn) - Italy
Tel. 0824.865004Fax 0824.865004
www.erbagil.com [email protected]
Ozone reacts with double bonds of the Oleic Acid and forms the stable Ozonides with Vitamin E Acetate
Once in contact with skin and mucosa the stable Ozonidesdevelop partially in Bio-peroxides and Molecular Oxygendevelop partially in Bio-peroxides and Molecular Oxygen
INDIKACIJEZa lokalno uporabo pri lajšanju proktitisa, analnih
razjed, hemoroidov, ulceroznega proktokolitisa. Popravlja škodo, ki jo povzroči sevanje in deluje
proti vnetjem, pordelosti, srbenju, pekočem občutku in proti oteklinam. Vsebuje mazivo in ima zaščitno delovanje ter stimulira regeneracijo tkiva
in ponovno epitelizacijo.
UPORABATemeljito očistite prizadeto območje s
čistilnim sredstvom Idrozoilom. Proktitis : pritrdite na tubo priloženo rektalno šobo in nanesite na prizadeto območje ponoči, zjutraj in
po vsakem odvajanju, dokler ni stanje nadzorovano. Razjede in hemoroidi: nanesite proizvod direktno na
prizadeto področje. Čas izboljšanja je odvisen od hitrosti terapevtskega odziva.
LITERATURA Nathália R. de Almeida, Adilson Beatriz, Ana Camila Micheletti and Eduardo J. De Arruda, Ozonized vegetable oils and therapeutic properties: A review. Orbital, The Electronic Journal Of Chemistry, Volume 4, Number 4, October-December 2012V. Travagli, I. Zanardi, G. Valacchi, and V. Bocci, Ozone and Ozonated Oils in Skin Diseases. Mediator of In�ammation, Volume 2010 (2010), Article ID 610418V. Travagli, I. Zanardi, V. Bocci, Topical applications of ozone and ozonated oils as anti-infective agents: an insight into the patent claims. Recent Patents on Anti-Infective Drug Discovery, Volume 4, Number 2, June 2009, pp. 130-142(13)Kim HS, Noh SU, Han YW, Kim KM, Kang H, Kim HO, Park YM, Therapeutic e�ects of topical application of ozone on acute cutaneous wound healing. J Korean Med Sci, 12 June 2009 Ana del Rosario Barroetabeña Reyes, Alejandro Sánchez Anta, Juan Guerra Miranda, Acción del aceite ozonizado sobre el proceso in�amatorio en heridas de piel de animales de experimentación. Correo Cientí�co Médico de Holguín 2002Gri�n N, Zimmermann DD, Briel JW, Gruss HJ, Jonas M, Acheson AG, Neal K, Schole�eld JH, Schouten WR, Topical L-arginine gel lowers resting anal pressure: possible treatment for anal �ssure. Dis Colon Rectum. 2002 Oct; 45 (10): 1332-6Matsumoto, Akiyo; Shotaro Sakurai; Nariko Shinriki; Shigeru Suzuki & Toshiaki Miura, Therapeutic E�ects of Ozonized Olive Oil in the Treatment of Intractable Fistula and Wound after Surgical Operation. Japan, J. Clin. Surg., 61(6) 7-13 (2000)
with
It prevents and treats the onset of disease, even in case of radiotherapy
OZOILE®
Stable Ozonideswith Vitamin E acetate
ERBAGIL PATENT
100% MADE IN ITALYCerti�ed
Management SystemCerti�ed
Management SystemACCREDIA
Italian National Accreditation Body
100%
MA
DE
IN ITALY CERTIFI CATE
IT PI
UNI ENI ISO 13485:2012 UNI ENI ISO 9001:2008
Network
KREMA
