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Nov.2008Miss.TAHANI AL-SHEHRI
Haemoglobin ( Hb) & anaemia
Objective
To estimate the Hb concentration in the blood sample.
To assess the condition of patient by such an estimation.
Further experience in the use of kits.
Introduction and principle Haemoglobin
Introduction and principle Haemoglobin
Rate of Hb Synthesis & RBCs Formation related to Oxygen content of blood O2 content Hb Syn
Ex. Anoxia / Hypoxia Blood loss or Hemolysis
Hb synthesis 6-8 foldsAnaemia
Hb synthesis
Erythropoieosis Synthesis of erythrocyteTack place in bone marrow erythrocyte are derived from primitive
nucleated cell in bone marrow by successive process of mitosis & maturation.
Factor required to manufacture RBCVarity of hormoneTrace metalsEnzymes Co enzymesEssential a.a e.g glycineIron
Hb Catabolism
AnemiaState in which the Hb conc. in blood less
than the normal level.Normal level of Hb :
Man 800g =14-18g/dLWoman 600g =12-16g/dL
Causes of anemia : Excessive blood loss due to bleeding rate of erythrocyte destruction (hemolytic
anemia ) rate of erythrocyte production
Classification of anemia