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noninvasive lung volumemeasurement
what is emkaBELT?
non-invasive tool to measure thoracic and abdominal volume based on the respiration inductance plethysmography (rip)
monitors respiration
monitors bronchoconstriction
what is respiratory inductance plethysmography (rip)?elastic and wire belts worn around the chest and abdomen.
alternating current (AC) passed through belt generates a magnetic field.
breathing changes the cross-sectional area of the animal’s body and shape of the belt’s magnetic field.
this induces a change in resonance frequency of the circuit.
the measure of this frequency provides a linear representation of cross-sectional area
what does it measure? 1/3
used without calibration (factory settings)
provides exact values for:
breathing frequencyduration of inspiration and expirationduration ratiosasynchrony between thoracic and abdominal movements (phase shift)apnea, emesis, cough
indications of absolute values and assessment of relative changes for:
tidal volume and minute ventilationmaximum and minimum flow
what does it measure? 2/3
used with calibration
precise, subject specific calibration is possible with a mask
requires 2 min procedure prior to recordinguses extra data channel linked to fleisch tube & mask
provides exact values for:
tidal volume and minute ventilation maximum and minimum flowsrelative contribution of thorax and abdomen
what does it measure? 3/3
bronchoconstriction
assessed with phase asynchrony in abdominal and thoracic signalsand the calculation of phase angle from:
thoracic vs. abdominal loops (dogs)
abdominal vs. thoracic loops (primates)
the emkaBELT
system elements
2 extension belts (with connectors)
1 emkaPACK transmitter equipped with 1 integrated emkaBELT module
1 receiver
fitting respiration belts to the animal
calibration of respiration belts
ecg (dog)
lung volume (dog)
ecg & respiration
breath by breath analysis of respiration
ecg & respiration
breath by breath analysis of respiration
flows (dog)
correlation between belt and flow-derived volume
signal from belt
volume from mask
thoracic signal
abdominal signal
flow from mask
volume from mask
in the absence of drugs there is good synchrony of thoracic & abdominal signals courtesy of CIT
baseline period: near perfect synchrony
carbachol (a brochoconstrictor) induces asynchrony of thoracic & abdominal signals courtesy of CIT30 mn after administration: near total asynchrony
control data before adminstration of theophyllinecourtesy of Pfizer, Groton
control dose methylcellulose
effects of theophylline (bronchodilator / stimulant -3mg/kg po) on signal shape courtesy of Pfizer,Groton
10 minutes post-dose
effects of theophylline on respiratory rate courtesy of Pfizer, Groton
4 dog group results for theophylline (3mg/kg po)
dosebaseline
effects of nebulized methylcholine (2mg/mL) on phase angle courtesy of Pfizer, Groton
Breath waveforms are in near perfect phase opposition.
effects of nebulized methylcholine (2mg/mL) on phase angle courtesy of Pfizer, Groton
4 animal group results
controlbaseline dose
abdominal & thoracic signals during anesthesia (left) and during challenge (right)
recovery from ascaris suum-cynomologus macaques courtesy of Schering-Plough
recovery from ascaris suum-cynomologus macaques courtesy of Schering-Plough
asynchrony changes as displayed by thoracic/abdominal volume loops
why use emkaBELT?
signal quality is excellent
belt length is easily adjustable to animal size
calibration from mask is valid, reliable and easy
positive controls repeatedly produce expected effects
asynchrony (phase shift) assessment is an efficient and reliable indicator of bronchoconstriction
apnea is detected using shape-recognition algorithm
inclusion of safety pharmacology endpoints into general toxicology studies
“Safety pharmacology studies measure functional indices of potential toxicity. These functional indices may be investigated in separate studies or incorporated in the design of toxicity studies.” (ICH S6)
“An assessment of vital organ function, including cardiovascular, respiratory and central nervous systems, should be available before the initiation of clinical studies; such parameters could be included in general toxicology studies.” (ICH S9)
why use emkaBELT?
emka TECHNOLOGIES’ telemetry is
openit provides analog outputs at no extra cost so you can use the software of your choice!
visit our websites for complete product descriptions, case studies, a knowledge base, & frequently asked questions:
www.emka.fr
&
telemetry.emka.fr
website
contact us!
please contact us to see how we can help you meet your telemetry research goals!whatever the scale and complexity of your project, please contact us for a professional, competitively priced solutions adapted to your needs
emka TECHNOLOGIES S.A. 59, bd. général Martial Valin - 75015 Paris - FRANCE phone: +33 (0)1 40 60 76 00 fax: +33 (0)1 40 60 65 66
sales and support office for North America:
emka TECHNOLOGIES Inc. 307 Annandale Road, suite 203 Falls Church, VA 22042 - USAphone: +1 (703) 237-9001 fax: +1 (703) 237-9006
for all inquiries contact : [email protected]
distributor for China:
Beijing GuangYuanDa Science and Technology Co. Ltd. Suite 305 Hongchen Business Center,No 20 ZhongFangLi, Chaoyang District, Beijing 100020 phone: +86-10-65019453 fax: +86-10-65019453 contact: [email protected]
distributor for Japan:
Physio-Tech Co., Ltd 6-3, Iwamoto Cho 1-Chome Chiyoda-Ku, Tokyo 101-0032 +81 3 3864 2781 +81 3 3864 2787 contact: [email protected] Physio-Tech website: www.physio-tech.co.jp
