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NIHR CLAHRC for NIHR CLAHRC for
Northwest Northwest LondonLondon
Collaborations for Leadership in Collaborations for Leadership in Applied Health Research and CareApplied Health Research and Care
November 2008November 2008
Background to CLAHRC bidsBackground to CLAHRC bids
• Closing the second translational gap - Cooksey ReportClosing the second translational gap - Cooksey Report– ‘‘Accelerating research into better care’ Accelerating research into better care’
• CLAHRC bids aimedCLAHRC bids aimed– Chronic DiseaseChronic Disease– Public HealthPublic Health
• Partnerships between NHS and UniversityPartnerships between NHS and University– Broad partnershipBroad partnership– Spans the Comprehensive Local Research Network Spans the Comprehensive Local Research Network
(regional)(regional)
NIHR CLAHRC for NW LondonNIHR CLAHRC for NW London
Improve the delivery of innovative research to Improve the delivery of innovative research to provide the highest quality of patient careprovide the highest quality of patient care
Devise and evaluate a systematic approach for the Devise and evaluate a systematic approach for the rapid adoption of clinically effective interventionsrapid adoption of clinically effective interventions
Develop a model for the conduct and application of Develop a model for the conduct and application of health research that is transferable across the NHShealth research that is transferable across the NHS
Develop research capacity and capability across Develop research capacity and capability across northwest Londonnorthwest London
The PartnershipThe Partnership
• Chelsea and Westminster NHS Foundation TrustChelsea and Westminster NHS Foundation Trust• Imperial College, LondonImperial College, London• Acute Trusts in NW LondonAcute Trusts in NW London• Primary Care Trusts in NW LondonPrimary Care Trusts in NW London• Other NHS OrganisationsOther NHS Organisations
– NHS LondonNHS London– NHS Institute for Improvement and InnovationNHS Institute for Improvement and Innovation– NHS DirectNHS Direct
• Other HEIOther HEI– London School of Hygiene and Tropical Medicine London School of Hygiene and Tropical Medicine
• CommercialCommercial
Funding Sources Funding Sources
• UKCRN PortfolioUKCRN Portfolio– Funding directed towards high quality research Funding directed towards high quality research
• Competitive at a National LevelCompetitive at a National Level• Peer ReviewedPeer Reviewed
• Competitive FundingCompetitive Funding– National Institute for Health ResearchNational Institute for Health Research
• http://www.nihr.ac.ukhttp://www.nihr.ac.uk– Association of Medical Research CharitiesAssociation of Medical Research Charities
• http://www.amrc.org.ukhttp://www.amrc.org.uk
• Commercial FundingCommercial Funding– Research Networks Research Networks
• http://www.ukcrc.orghttp://www.ukcrc.org• http://www.ukcrn.org.ukhttp://www.ukcrn.org.uk
FundingFunding
• CLAHRC fundingCLAHRC funding– Through host NHS organisationThrough host NHS organisation
What are the opportunitiesWhat are the opportunities
• Increase research capacityIncrease research capacity
• Awareness of CLAHRC purposeAwareness of CLAHRC purpose
• Supporting NHS staff Supporting NHS staff – Research Research – Establishing an evidence baseEstablishing an evidence base
• Undertaking research Undertaking research – Use of informationUse of information– Knowledge management/transferKnowledge management/transfer
• E learning E learning – Maximising across the CLAHRC(s)Maximising across the CLAHRC(s)
Patient and Public Patient and Public involvementinvolvement• AccessAccess
• DisseminationDissemination
• Supporting PPI in generalSupporting PPI in general
Funding ApplicationsFunding Applications
• Read the guidelinesRead the guidelines– Make sure your proposal is within the scope of the bid Make sure your proposal is within the scope of the bid
and meets all criteriaand meets all criteria
• Seek financial advice early!Seek financial advice early!– Familiarise yourself with local requirementsFamiliarise yourself with local requirements– Check application guidelinesCheck application guidelines
• Research Costs (research funder e.g. NIHR, MRC)Research Costs (research funder e.g. NIHR, MRC)• NHS Support Costs (DH/NIHR via research networks)NHS Support Costs (DH/NIHR via research networks)• Treatment Costs (Commissioning) Treatment Costs (Commissioning)
How to improve applicationsHow to improve applications
• Service user involvementService user involvement– Development of the grant applicationDevelopment of the grant application– Design and management of the research Design and management of the research – Undertaking researchUndertaking research– AnalysisAnalysis– Dissemination of findingsDissemination of findings
• Clear dissemination policyClear dissemination policy
• Field a strong teamField a strong team
• Invite critical review before you submitInvite critical review before you submit
Ethics and GovernanceEthics and Governancehttp://www.nres.npsa.nhs.uk/http://www.nres.npsa.nhs.uk/
• What requires ethical approval?What requires ethical approval?– Includes tissue and data collectionIncludes tissue and data collection– New IRAS application process (New IRAS application process (www.myresearchproject.org.ukwww.myresearchproject.org.uk))
• Seek advice from your local research officeSeek advice from your local research office– Ethical approval (Site Specific Assessment)Ethical approval (Site Specific Assessment)– Trust R&D approvalTrust R&D approval– Other approvalsOther approvals
• EudraCT – registering RCTsEudraCT – registering RCTs• MHRA (investigational medicinal products and medical MHRA (investigational medicinal products and medical
devices)devices)• PIAGPIAG
• Research Governance FrameworkResearch Governance Framework– Good Clinical Practice Training Good Clinical Practice Training – Monitoring and AuditingMonitoring and Auditing
Opportunities IOpportunities I
• Research Project (site or organisation)Research Project (site or organisation)– Key research staff or delivery staff fundedKey research staff or delivery staff funded– Training and support from expert teamTraining and support from expert team– Peer reviewed publicationsPeer reviewed publications
• CLAHRC PartnerCLAHRC Partner– Full access to training programmeFull access to training programme– Staff developmentStaff development– Dissemination – supported implementationDissemination – supported implementation– Support programmeSupport programme
Opportunities IIOpportunities II• Round 1 April 2008Round 1 April 2008
– Medicine managementMedicine management– COPD and PneumoniaCOPD and Pneumonia– HIVHIV
• Round 2 and 3 Round 2 and 3 – Open competition bids from NW London partnershipsOpen competition bids from NW London partnerships– Technology, therapeutics, service deliveryTechnology, therapeutics, service delivery– Roll-Out of projects from Round 1 Roll-Out of projects from Round 1
• Links with other research programmes Links with other research programmes
• Patient and public focus Patient and public focus
• Action Research and Improvement MethodologyAction Research and Improvement Methodology