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John M. Boone, Ph.D., FAAPM, FSBI, FACR Professor and Vice Chair (Research) of Radiology Professor of Biomedical Engineering University of California Davis Medical Center Sacramento, California New ICRU * Report on CT Dosimetry 2013 ICTP/IAEA Training Course on Radiation Protection of Patients Trieste 1 * International Commission on Radiation Units (and Measurement)

New ICRU Report on CT Dosimetry - International Centre …indico.ictp.it/event/a12208/session/11/contribution/7/material/0/0.pdfNew ICRU* Report on CT Dosimetry 2013 ICTP/IAEA Training

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John M. Boone, Ph.D., FAAPM, FSBI, FACR

Professor and Vice Chair (Research) of Radiology Professor of Biomedical Engineering

University of California Davis Medical Center Sacramento, California

New ICRU* Report on CT Dosimetry

2013 ICTP/IAEA Training Course on Radiation Protection of Patients Trieste

1

*International Commission on Radiation Units (and Measurement)

ICRU Report 87: Radiation Dose and Image Quality Assessment in CT

2

Disclosures Paid Consultant to:

Varian Imaging Systems

Alston and Bird LLC

CardioInsight

DXray

Royalty Income from:

Lippincott Williams and Wilkins

Samsung Corporation

Research Funding from:

Stanford Research Institute

University of Pittsburgh

Siemens Medical Systems

Hologic Corporation

National Institutes of Health (NIBIB)

3

Introduction & Historical CT Dose Metrics

Dose dependency on patient size

Dose and CT scan length

Phantoms and radiation meters

ICRU extension to AAPM Report 111

Summary

ICRU Report on CT Dosimetry

4

position

do

se

Z=0 -Z +Z

50

100

50

1( )

mm

mm

CTDI D z dznT

100 mm

CTDI - based Dose Metrics

CTDI100 (center & peripheral)

The Tools

CTDIw

CTDIvol

DLP

The Metrics

The Methods

6

7

CTDI is a good measure of CT dose to a large plastic

phantom, but is not a stand-alone metric for patient dose

etcetera….

Med Phys 2003

Introduction & Historical CT Dose Metrics

Dose dependency on patient size

Dose and CT scan length

Phantoms and radiation meters

ICRU extension to AAPM Report 111

Summary

8

ICRU Report on CT Dosimetry

32 cm

r = 1.19

47”

120 cm waistline

28 cm ≈ 35”

88 cm waistline

9 UC Davis Data

Dose Dependency on patient size

32 cm PMMA phantom 1138 cm2

average patient 615 cm2

85% bigger by

mass

r = 1.19 r = 1.0

10

11

practical methods to correct dosimetry estimates for patient size

12

14

Studied Size-dependent CT Dose

TG-204 Approach

Four Independent Research Groups

15

Family of physical phantoms Cynthia McCollough, Mayo Clinic

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standard phantoms Tom Toth & Keith Strauss

17

Anthropomorphic Monte Carlo phantoms Mike McNitt-Gray, UCLA

18

Monte Carlo phantoms (1 – 50 cm) John M. Boone, UC Davis

19

Figure 2

AP

lateral effective diameter

circle of equal area

20

patient size

do

se

CTDIvol

32 cm PMMA

normalization point

21

corr

ecti

on

fac

tor

CTDIvol

32 cm

after normalization

1.0

patient size

22

Co

nve

rsio

n F

acto

r

water-equivalent diameter (cm)

32 cm 120 kV

23

0 1 5 10 15

age in years

Co

nve

rsio

n F

acto

r 16 cm 120 kV

24

CTDIvol is indicated on most scanners…..

CTDIvol mGy 13.2

25

26

27

determine patient size

28

determine patient size

Dw

CTDIvol (mGy) × = SSDE (mGy) f

air kerma absorbed dose

SSDE conversion factor

Size-Specific Dose Estimate (SSDE)

29

SSDE conversion factor

CT Radiograph

Example of SSDE calculation from localizer view

5.40 mGy = CTDIvol

SSDE = 5.4 mGy × 2.5

SSDE = 13.5 mGy

Example of SSDE calculation from localizer view

Introduction & Historical CT Dose Metrics

Dose dependency on patient size

Dose and CT scan length

Phantoms and radiation meters

ICRU extension to AAPM Report 111

Summary

32

ICRU Report on CT Dosimetry

Problems with CTDIvol

32 cm diameter PMMA phantom

10 cm scan length 33

15 cm phantom

L

10 cm

34

JM Boone, Dose spread functions in computed tomography: A Monte Carlo study”, Med Phys 36, 4547-4554 (2009)

How long are the scatter tails in CT?

62%

35

JM Boone, Dose spread functions in computed tomography: A Monte Carlo study”, Med Phys 36, 4547-4554 (2009)

How long are the scatter tails in CT?

10% 10%

80% ~130 mm

36

JM Boone, Dose spread functions in computed tomography: A Monte Carlo study”, Med Phys 36, 4547-4554 (2009)

How long are the scatter tails in CT?

1% 1%

98% 400 mm

37

Dose profiles as a function of Scan Length

scan length

38

Equilibrium Dose as a function of Scan Length

Deq

Do(L

)

39

40

Integrating thimble chamber 41

TG-111 Method

42

TG-111 Method

43

TG-111 Method

44

TG-111 Method

45

h = scatter / primary

P P S

46

Introduction & Historical CT Dose Metrics

Dose dependency on patient size

Dose and CT scan length

Phantoms and radiation meters

ICRU extension to AAPM Report 111

Summary

47

ICRU Report on CT Dosimetry

ICRU / AAPM (TG-200) Dosimetry Phantom

48

phantoms

section A section B section C

Phantom is polyethylene 60 cm long by 30 cm in diameter

Each section is 20 cm long and weighs 13.7 kg (30 lbs)

compared to 32 cm diameter PMMA: 14.4 kg (5% lighter)

Total phantom 41.1 kg (90 lbs)

49

50

51

52

Integrating thimble chamber

real time probes

signal

time

53

18 mm*

The thimble chamber with

real time (>1000 Hz) readout rates

*active length

54

Introduction & Historical CT Dose Metrics

Dose dependency on patient size

Dose and CT scan length

Phantoms and radiation meters

ICRU extension to AAPM Report 111

Summary

55

ICRU Report on CT Dosimetry

56

real time thimble chamber 57

ICRU Method

58

beam profile 59

60

61

ICRU method

TG-111 method

Introduction & Historical CT Dose Metrics

Dose dependency on patient size

Dose and CT scan length

Phantoms and radiation meters

ICRU extension to AAPM Report 111

Summary

62

ICRU Report on CT Dosimetry

CTDI-based methods need to be updated

SSDE is a method for adjusting for patient size

Scan length dose dependencies h(L)

Longer phantoms and faster radiation meters

Methods for automatic size detection

ICRU CT Report Available Q3 2013

TG-111/ICRU

TG-220

TG-204/ICRU

TG-200/ICRU

63

ICRU Report on CT Dosimetry

Figures from CT Chapter

2012 edition

Introduction & Historical CT Dose Metrics

Dose dependency on patient size

Dose and CT scan length

Phantoms and radiation meters

ICRU extension to AAPM Report 111

Summary

65

ICRU Report on CT Dosimetry

66

Cobra: Boone

67

Computer simulation

68

Computer simulation

69

Physical Measurement

70

71