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8/8/2019 NEPHROTIC SYNDROME2
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NEPHROTIC SYNDROME
BY,
PUTRI NOOR ZULAIKHA
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DEFINITION
Triad of proteinuria
Spot urine protein:creatinine ratio
Hypoalbuminaemia
Oedema
Severe hyperlipidaemia
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CAUSES
CAUSES OF NEPHROTIC SYNDROME
ALL GROMERULONEPHRITIESAND MINIMAL CHANGE OFGLOMERULUS LESIONS
SYSTEMIC VASCULITIDES, MAINLYSYSTEMIC LUPUS ERYTHEMATOSUS
DIABETIC GLOMERULOSCLEROSIS
AMYLOIDOSIS
DRUGS
ALLERGIES
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CLASSIFICATION
Primary causes of nephrotic syndrome include, inapproximate order of frequency:
Minimal-change nephropathy
Focal glomerulosclerosis
Membranous nephropathy
Hereditary nephropathies
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Secondary causes include, again in order ofapproximate frequency:
Diabetes mellitus
Systemic Lupus erythematosus
Amyloidosis
Viral infections (eg, hepatitis B, hepatitis C,human immunodeficiency virus [HIV] )
Preeclampsia
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CLINICAL
History The first sign of nephrotic syndrome in children is
usually swelling of the face; this is followed by swellingof the entire body.
Adults can present with dependent edema. Foamy urine may be a presenting feature. A thrombotic complication, such as deep vein
thrombosis of the calf veins or even a pulmonaryembolus, may be the first clue indicating nephrotic
syndrome. Additional historical features that appear can be
related to the cause of nephrotic syndrome. Thus, therecent start of a nonsteroidal anti-inflammatory drug(NSAID) or a 10-year history of diabetes may be veryrelevant.
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Physical
Edema is the predominant feature of nephrotic
syndrome and initially develops around the eyes andlegs. With time, the edema becomes generalized andmay be associated with an increase in weight, thedevelopment of ascites, or pleural effusions.
Hematuria and hypertension manifest in a minorityof patients.
Additional features on exam will vary according tocause and as a result of whether or not renal function
impairment exists. Thus, in the case of longstandingdiabetes, there may be diabetic retinopathy, whichcorrelates closely with diabetic nephropathy. If thekidney function is reduced, there may be
hypertension and/or anemia.
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LAB STUDIES..
Urinalysis
Time collection of urinary protein Serum tests for kidney function
urine protein electrophoresis.
The serum albumin
Ultrasonographic
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Granular cast
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Waxy cast
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Hyaline cast/ fatty cast
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RBC cast
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Acute management of childhood
nephrotic syndrome has generalized edema severe enough to cause
respiratory distress
tense scrotal or labial edema, if he or she hascomplications (eg, bacterial sepsis, peritonitis,pneumonia, thromboembolism)
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Diuretics will be needed; furosemide (1
mg/kg/d) and spironolactone (2 mg/kg/d) willhelp when fluid retention is severe, provided nosigns of renal failure or volume contraction areevident. Achieving a satisfactory diuresis isdifficult when the patient's serum albumin levelis less than 1.5 g/dL. Albumin at 1 g/kg may begiven, followed by intravenous furosemide.Complications may occur, including pulmonaryedema. Some evidence suggests that albumin
may delay the response to steroids and may eveninduce more frequent relapses, probably bycausing severe glomerular epithelial damage.Fluid removal and weight loss remain transient
unless proteinuria remits
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With regard to infection, oral penicillin can beprescribed as prophylaxis for children with grossedema. Abdominal paracentesis should beperformed if the patient develops signs ofperitonitis, and any bacterial infection should betreated promptly. A nonimmune patient with
varicella should receive zoster immunoglobulintherapy if exposed to chickenpox, andacyclovir should be given if the patient developschickenpox
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Acute management of adultnephrotic syndrome Diuretics will be needed; furosemide,
spironolactone, and even metolazone may beused. Volume depletion may occur with diureticuse, which should be monitored by assessmentof symptoms, weight, pulse, and blood pressure
Anticoagulation has been advocated by some for
use in preventing thromboemboliccomplications, but its use in primaryprevention is of unproven value.
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Hypolipidemic agents may be used, but if thenephrotic syndrome cannot be controlled, therewill be persistent hyperlipidemia
In secondary nephrotic syndrome, such as that
associated with diabetic nephropathy,angiotensin-converting enzyme (ACE) inhibitorsand/or angiotensin II receptor blockers are widelyused. These may reduce proteinuria by reducing
the systemic blood pressure, by reducingintraglomerular pressure, and also by directaction on podocytes.
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THANK YOU