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Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
1 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
acyclovir doses less than 250 mg
500 mg/10 mL (50 mg/mL)
n/a
2 step DILUTION 1- Withdraw exact dose
2- Further dilute with NS to final concentration of 5 mg/mL
5 mg/mL 60 minutes KCL- Y D5W-Y NS-Y
Adenosine doses less than 0.6 mg
6 mg/2 mL (3 mg/mL)
NS
Withdraw 1 mL (3 mg) of adenosine + 9 mL Normal Saline Final volume=10 mL
0.3 mg/mL
IV push over 1 second followed by immediate NS flush in IV line closest to heart
KCL- Y D5W-Y NS-Y
For SVT Dose=0.05 mg/kg, increase dose in 0.05 mg/kg increments every 2 minutes until return of sinus rhythm. Max dose 0.25 mg/kg
Adenosine doses 0.6 mg or greater
6 mg/2 mL (3 mg/mL)
n/a Withdraw exact dose 3 mg/mL
IV push over 1 second followed by immediate NS flush in IV line closest to heart
KCL- N D5W-Y NS-Y
For SVT Dose=0.05 mg/kg, increase dose in 0.05 mg/kg increments every 2 minutes until return of sinus rhythm. Max dose 0.25 mg/kg
alprostadil infusion 500 mcg/1 mL (500 mcg/mL)
N/A
500 mcg (1 mL) alprostadil + 49 mL D5W Final volume: 50 mL
10 mcg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours
KCL- Y D5W-N NS-Y
amiodarone infusion 150 mg/3 mL (50 mg/mL)
N/A
100 mg (2mL) amiodarone + 48 mL D5W Final volume: 50 mL
2 mg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours
KCL- Y D5W-Y NS-Y
Amphotericin B-liposomal (Ambisome®)
doses less than 50 mg
50 mg SW
2 step DILUTION 1- Add 12 mL SW to make
4 mg/mL
2- Withdraw exact dose and further dilute with D5W to final concentration 1 mg/mL
1 mg/mL 120 minutes KCL-N NS-N D5W-Y
Prepared by Pharmacy Must be filtered with greater than 1 micron filter
Compatible with D5W only
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
2 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
ampicillin doses less than 100 mg
250 mg
SW (preferred) NS D5W (Stability
grossly ↓, not recommended)
Add 2.5 mL SW and withdraw exact dose Add remaining volume to equal 1 mL final volume
n/a 15 minutes KCL- Y D5W-N NS-Y
Use within 1 hour of reconstitution
ampicillin doses 100-250 mg
250 mg
SW (preferred) NS D5W (Stability grossly ↓, not recommended)
Add 2.5 mL SW and withdraw exact dose 100 mg/mL 15 minutes KCL- Y D5W-N NS-Y
Use within 1 hour of reconstitution
ampicillin doses 251 mg or greater
500 mg
SW (preferred) NS D5W (Stability
grossly ↓, not recommended)
Add 5 mL SW and withdraw exact dose 100 mg/mL 15 minutes KCL- Y D5W-N NS-Y
Use within 1 hour of reconstitution
Atropine doses less than 0.01 mg
0.5 mg/5 mL prefilled syringe
(0.1 mg/mL)
n/a
Withdraw 1 mL (0.1 mg) of atropine ADD 9 mL NS Final volume=10 mL Final concentration=0.01 mg/mL
0.01 mg/mL Use this to withdraw your bolus dose
Withdraw dose (using 0.01 mg/mL concentration) and ADD extra NS to make 1 mL Give by manual IVP over 1 minute
KCL-Y D5W-Y NS-Y
Atropine doses 0.01 mg or greater
0.5 mg/5 mL prefilled syringe
(0.1 mg/mL)
n/a
Withdraw exact dose needed, add extra volume of NS if needed to make 1 mL
n/a Give by manual IVP over 1 minute
KCL-Y D5W-Y NS-Y
azithromycin (Zithromax®)
500 mg SW
2 step DILUTION 1- Add 5 mL SW to make
100 mg/mL
2- Withdraw exact dose and further dilute with NS to a final concentration of 2 mg/mL
2 mg/mL 60 minutes KCL-N D5W-Y NS-Y
blood products (includes platelets, FFP, Cryoprecipitate)
n/a n/a n/a n/a Infuse per MD order
n/a
Use Blood filter Expires in 4 hours!
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
3 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
caffeine citrate doses less than 20 mg
60 mg/3 mL (20 mg/mL)
n/a Withdraw exact dose Add Remainder of volume to make final volume 1 mL with D5W
n/a 10 minutes KCL-Y D5W-Y NS-Y
caffeine citrate doses 20 mg or greater
60 mg/3 mL (20 mg/mL)
n/a Withdraw exact dose and infuse 20 mg/mL 10 minutes KCL-Y D5W-Y NS-Y
calcium gluconate 1000 mg/10 mL
(100 mg/mL) n/a
Withdraw exact dose Dilute with NS equal parts for final concentration 50 mg/mL
50 mg/mL 60 minutes KCL-Y D5W-Y NS-Y
caspofungin
doses less than 25 mg 50 mg NS
2 step DILUTION 1- Add 10.8 mL of NS to make
5 mg/mL
2- Withdraw exact dose and further dilute with NS to final concentration of 0.5 mg/mL
0.5 mg/mL 60 minutes KCL-Y D5W-N NS-Y
Prepared by pharmacy Note: dosing in BSA*
ceFAZolin doses less than 100 mg
(Ancef®) 1000 mg
NS D5W SW
Add 10 mL NS and withdraw exact dose Add remaining volume to equal 1 mL final volume
n/a 30 minutes KCL-Y D5W-Y NS-Y
ceFAZolin doses 100 mg or greater (Ancef®)
1000 mg NS D5W SW
Add 10 mL NS and withdraw exact dose
100 mg/mL 30 minutes KCL-Y D5W-Y NS-Y
cefotaxime doses less than 100 mg
(Claforan®) 1000 mg
NS D5W SW
Add 10 mL NS and withdraw exact dose Add remaining volume to equal 1 mL final volume
n/a 30 minutes KCL-Y D5W-Y NS-Y
cefotaxime doses 100 mg or greater (Claforan®)
1000 mg NS D5W SW
Add 10 mL NS and withdraw exact dose 100 mg/mL 30 minutes KCL-Y D5W-Y NS-Y
cefTAZidime doses less than 100 mg
(Fortaz®) 1000 mg
NS D5W SW
Add 10 mL NS and withdraw exact dose Add remaining volume to equal 1 mL final volume
n/a 30 minutes KCL-Y D5W-Y NS-Y
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
4 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
cefTAZidime doses 100 mg or greater (Fortaz®)
1000 mg NS D5W SW
Add 10 mL NS and withdraw exact dose 100 mg/mL 30 minutes KCL-Y D5W-Y NS-Y
cefTRIAXone (Rocephin®)
1000 mg NS D5W SW
Add 10 mL NS and withdraw exact dose 100 mg/mL 30 minutes
KCL-Y D5W-Y NS-Y
Not to be used in premature infants or patients with hyperbilirubinemianot in NICU pyxis,
clindamycin (Dalacin C®)
300 mg/2 mL (150 mg/mL)
n/a
2 step DILUTION 1- Withdraw exact dose
2- Further dilute with NS to final concentration of 10 mg/mL
10 mg/mL 30 minutes
KCL-Y D5W-Y NS-Y
cloxacillin doses less than 20 mg
500 mg SW
3 step DILUTION 1- Add 5 mL SW to make
100 mg/mL concentration
2- Withdraw exact dose and further dilute with NS to final concentration of 20 mg/mL
3- Add remainder of volume to make 1 mL
n/a 30 minutes
KCL-N D5W-Y NS-Y
cloxacillin doses 20 mg or greater
500 mg SW
2 step DILUTION 1- Add 5 mL SW to make
100 mg/mL concentration
2- Withdraw exact dose and further dilute with NS to final concentration of 20 mg/mL
20 mg/mL 30 minutes
KCL-N D5W-Y NS-Y
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
5 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
dexamethasone doses less than 1 mg
20 mg/5 mL (4 mg/mL)
n/a
3 step DILUTION 1- Withdraw exact dose
2- Further dilute with NS to a final concentration of 1 mg/mL
3- add remainder of volume to make 1 mL
n/a 15 minutes KCL-Y D5W-Y NS-Y
See example for dilution
dexamethasone doses 1 mg or greater
20 mg/5 mL (4 mg/mL)
n/a
2 step DILUTION 1- Withdraw exact dose
2- Further dilute with NS to a final concentration of 1 mg/mL
1 mg/mL 15 minutes KCL-Y D5W-Y NS-Y
See example for dilution
DOBUTamine 250 mg/20 mL (12.5 mg/mL)
n/a
80 mg (6.4 mL) of DOBUTamine + 43.6 mL D5W Final volume: 50 mL
1.6 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours
KCL-Y D5W-Y NS-Y
DOPamine infusion
400 mg/250 mL premixed bag (1.6 mg/mL)
n/a Withdraw 50 mL DOPamine into a 60 mL syringe (straight drug)
1.6 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours
KCL-Y D5W-Y NS-Y
EPINEPHrine infusion
1 mg/10 ml prefilled syringe (0.1 mg/mL)
n/a
0.5 mg (5 mL) EPINEPHrine + 45 ml D5W Final volume: 50 ml
0.01 mg/ml Continuous infusion Units=mcg/kg/min Stability: 24 hours
KCL-Y D5W-Y NS-Y
ertapenem doses less than 20 mg (Invanz®)
1000 mg NS
3 step DILUTION 1- Add 10 mL NS to make
100 mg/mL
2- Withdraw exact dose and further dilute with NS to final concentration of 20 mg/mL
3- Add remaining volume to equal 1 mL final volume
n/a 30 minutes KCL-Y D5W-N NS-Y
Prepared by pharmacy Incompatible with D5W
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
6 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
ertapenem doses 20 mg or greater (Invanz®)
1000 mg NS
2 step DILUTION 1. Add 10 mL NS to make
100 mg/mL
2. Withdraw exact dose and further dilute with NS to final concentration of 20 mg/mL
20 mg/mL 30 minutes KCL-Y D5W-N NS-Y
Prepared by pharmacy Incompatible with D5W
esmolol infusion 2500 mg/250 mL premixed bag (10 mg/mL)
n/a Withdraw 50 mL esmolol into a 60 mL syringe (straight drug)
10 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours
KCL-Y D5W-Y NS-Y
fentaNYL bolus doses less than 5 mCg
100 mcg/2 mL (50 mcg/mL)
D5W NS SW
Withdraw 1 mL (50 mCg) of fentaNYL ADD 9 mL D5W Final volume=10 mL Final concentration=5 mCg/mL
5 mcg/mL Use this to withdraw your bolus dose
Withdraw dose (using 5 mcg/mL concentration) and ADD extra D5W to make 1 mL and run on pump over 10 minutes (minimum over 3-5 minutes)
KCL-Y D5W-Y NS-Y
fentaNYL bolus doses 5 mCg or greater
100 mcg/2 mL (50 mcg/mL)
n/a Withdraw exact dose needed
n/a
If bolus dose is less than 1 mL (using straight drug from vial) ADD extra D5W/NS/SW to make 1 mL and run on pump over 10 minutes (minimum 3-5 minutes)
KCL-Y D5W-Y NS-Y
fentaNYL infusion 100 mcg/2 mL (50 mcg/mL)
n/a
100 mcg (2mL) fentanyl + 8 mL D5W Final volume: 10 mL
10 mcg/mL Continuous infusion Unit=mcg/kg/hour Stability: 30 hours
KCL-Y D5W-Y NS-Y
fluconazole (Diflucan®)
200 mg/100 mL premixed vial
(2 mg/mL) n/a Withdraw and infuse exact dose 2 mg/mL 120 minutes
KCL-Y NS-Y D5W-Y
Straight drug from vial
furosemide (Lasix®) bolus
40 mg/4 mL (10 mg/mL)
n/a Exact dose – No dilution 10 mg/mL IVP over 2-5 minutes
KCL-Y D5W-Y NS-Y
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
7 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
furosemide infusion 40 mg/4 mL (10 mg/mL)
n/a
40 mg (4 mL) furosemide + 36 mL D5W Final volume=40 mL
1 mg/mL Continuous infusion Units=mg/kg/hour Stability: 30 hours
KCL-Y D5W-Y NS-Y
ganciclovir 500 mg SW Prepared by pharmacy (Hazardous)
5 mg/mL
Infuse over 60 minutes Flush pre/post with NS
KCL-Y D5W-Y NS-Y
**Cytotoxic** must be prepared in chemo hood, contact 4WES for chemo bin for disposal of drug
gentamicin (Garamicin®) doses less than 5 mg
20 mg/2 mL (10 mg/mL)
n/a
3 step DILUTION 1- Withdraw exact dose
2- Further dilute with NS to 5 mg/mL
3- Add remaining volume to make 1 mL
n/a 60 minutes KCL-Y D5W-Y NS-Y
See example sheet-NOTE concentration of vial**
gentamicin (Garamicin®) doses 5 mg or greater
20 mg/2 mL (10 mg/mL)
n/a
2 step DILUTION 1 Withdraw exact dose
2. Further dilute with NS to 5 mg/mL
5 mg/mL 60 minutes KCL-Y D5W-Y NS-Y
See example sheet-NOTE concentration of vial**
glucagon infusion Glucagon kit (1 mg/mL)
w/glucagon diluent
Reconstitute glucagon kit 1 mg (1 mL) glucagon + 24 mL D10W Final volume: 25 mL
40 mcg/mL
Continuous infusion Units=mcg/kg/hour Stability: 24 hours
KCL-N D5W-Y NS-N
hydrocortisone 100 mg/2 mL Act-O-Vial (50 mg/mL)
n/a
Dilute per instructions on vial Withdraw 50 mg (1 mL) Insert in 50 mL NS bag Giving a final concentration 1 mg/mL Withdraw exact dose needed If dose is less than 1 mL add remaining volume to equal 1 mL final volume
1 mg/mL 15 minutes KCL-Y D5W-Y NS-Y
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
8 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
indomethacin IV 1 mg vial NS/SW only
Reconstitute 1 mg vial with 1 mL of NS/SW (to make 1 mg/mL) Withdraw dose needed and add enough NS/D5W to make final volume 2 mL
n/a 30 minutes
KCL-Y D5W-Y NS-Y
Special access NOT compatible with D10W
insulin infusion
300 units/3 mL
(100 units/mL) Insulin GE TORONTO
n/a
Withdraw 50 units (0.5 mL) insulin Inject in a 500 ml bag 0.9% NaCL Invert bag few times Withdraw 50 mL of solution into a 60 mL syringe and prime syringe tubing. Let insulin saturate tubing for at least 20 minutes prior to administration Discard remainder of bag
0.1 units/mL Continuous infusion Units=units/kg/hour
Stability: 24 hours
KCL-Y D5W-Y NS-Y
levETIRAcetam (Keppra®)
500 mg/5 mL (100 mg/mL)
n/a
2 step DILUTION 1- Withdraw exact dose
2- Further dilute with NS to 10 mg/mL
10 mg/mL 15 minutes KCL-N D5W-Y NS-Y
See example for dilution Special Access
lidocaine infusion
2000 mg/500 mL premixed bag (4 mg/mL )
n/a Withdraw 50 mL lidocaine into a 60 mL syringe (straight drug)
4 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours
KCL-Y D5W-Y NS-Y
linezolid (Zyvoxam®)
600 mg/300 mL premixed bag (2 mg/mL)
n/a Pharmacy to prepare 2 mg/mL 60 minutes KCL-Y D5W-Y NS-Y
lipids (SMOF®)
50,000 mg/250 mL premixed bag (200 mg/mL)
n/a Infuse as ordered over 24 hours n/a mL/hr KCL-Y D5W-Y NS-Y
See example sheet for rate calculation
LORazepam (Ativan®) Doses less than 0.4 mg
4 mg/mL (4 mg/mL)
n/a
Withdraw 1 mL (4 mg) of lorazepam ADD 7 mL NS Final volume=8 mL Final concentration=0.5 mg/mL
0.5 mg/mL Use this to withdraw your bolus dose
Withdraw dose (using 0.5 mg/mL concentration) and ADD extra NS to make 1 mL Give IVP over 5-10 minutes
KCL-Y D5W-Y NS-Y
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
9 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
LORazepam (Ativan®) Doses 0.4 mg or greater
4 mg/mL (4 mg/mL)
n/a Withdraw exact dose, if volume less than 1 mL add remaining volume to equal 1 mL final volume
4 mg/mL IVP over 5-10 minutes
KCL-Y D5W-Y NS-Y
magnesium sulfate 2000 mg/10 mL
(200 mg/mL) n/a
2 Step DILUTION 1- Withdraw exact dose
2- Further dilute with NS for a final concentration of 50 mg/mL
50 mg/mL
Electrolyte replacement: 60 minutes
KCL-Y D5W-Y NS-Y
Not in NICU pyxis
meropenem doses less than 20 mg (Merrem®)
500 mg SW
3 step DILUTION 1- Reconstitute with 10 mL
SW to make 50 mg/mL
2- Withdraw exact dose and further dilute to final concentration of 20 mg/mL with NS
3- Add remaining volume to equal 1 mL final volume
n/a 30 minutes KCL-Y D5W-Y NS-Y
meropenem doses 20 mg or greater (Merrem®)
500 mg SW
2 step DILUTION 1. Reconstitute with 10
mL SW to make 50 mg/mL
2. Withdraw exact dose and further dilute to final concentration of 20 mg/mL with NS
20 mg/mL 30 minutes KCL-Y D5W-Y NS-Y
metoclopramide (Maxeran®)
10 mg/2mL (5 mg/mL)
n/a
2 step DILUTION 1- Withdraw exact dose
2- Further dilute to 0.2 mg/mL with NS
0.2 mg/mL 30 minutes KCL-Y D5W-Y NS-Y
See example sheet
metroNIDAZOLE (Flagyl®)
500 mg/100 mL premixed bag (5 mg/mL)
n/a Already diluted Withdraw/Infuse exact dose
5 mg/mL 60 minutes KCL-Y D5W-Y NS-Y
Straight drug from premix bag protect from light
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
10 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
midazolam bolus doses less than 0.5 mg (Versed®)
5 mg/1 mL (5 mg/mL)
n/a
Withdraw 1 mL (5 mg) of midazolam ADD 9 mL D5W Final volume=10 mL, final concentration=0.5 mg/mL
0.5 mg/mL Use this to withdraw your bolus dose
Withdraw dose (using 0.5 mg/mL concentration) and ADD extra D5W to make 1 mL and run on pump over 10 minutes (minimum 3-5 minutes)
KCL-Y D5W-Y NS-Y
midazolam bolus doses 0.5 mg or greater (Versed®)
5 mg/1 mL (5 mg/mL)
n/a
*Note concentration of vial* NO dilution -Withdraw exact dose and add remaining D5W to make final volume 1 mL
n/a
IVP ONLY over 10 minutes (neofax)- minimum time 3-5 minutes
KCL-Y D5W-Y NS-Y
midazolam infusion (Versed®)
5 mg/1 mL (5 mg/mL)
n/a
10 mg (2mL) midazolam + 8 mL D5W Final volume=10 mL
1 mg/ml Continuous infusion Units=mg/kg/HOUR Stability: 30 hours
KCL-Y D5W-Y NS-Y
milrinone infusion 10 mg/10 mL (1 mg/mL)
n/a
10 mg (10 mL) milrinone + 40 mL D5W Final volume: 50 mL
0.2 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours
KCL-Y D5W-Y NS-Y
Morphine bolus doses less than 0.2 mg
2 mg/1 mL (2 mg/mL)
n/a
Withdraw 1 mL (2 mg) of morphine ADD 9 mL D5W Final volume=10 mL final concentration=0.2 mg/mL
0.1 mg/mL Use this to withdraw your bolus dose
Withdraw dose (using 0.2 mg/mL concentration)and ADD extra D5W to make 1 mL and run on pump over 10 minutes (minimum time 3-5 minutes)
KCL-Y D5W-Y NS-Y
morphine bolus doses 0.2 mg or greater
2 mg/1 mL (2 mg/mL)
n/a
NO dilution -Withdraw exact dose and add remaining diluent volume to make final volume 1 mL
n/a
IVPB 10 minutes (minimum time 3-5 minutes)
KCL-Y D5W-Y NS-Y
morphine infusion 2 mg/1 mL (2 mg/mL)
n/a
2 mg (1 mL) morphine + 49 mL D5W Final volume: 50 mL
40 mcg/mL Continuous infusion Units=mcg/kg/hour
Stability: 30 hours
KCL-Y D5W-Y NS-Y
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
11 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
naloxone (Narcan®)
2 mg/2 mL (1 mg/mL)
n/a No Dilution **Note concentration of vial**
1 mg/mL IVP over 30 seconds KCL-Y D5W-Y NS-Y
naloxone Infusion (Narcan®)
2 mg/2 mL (1 mg/mL)
n/a
0.2 mg (0.2 mL) naloxone + 49.8 mL NS Final Volume: 50 mL
4 mcg/mL Continuous infusion Units=mcg/kg/hour Stability: 24 hours
KCL-Y D5W-Y NS-Y
norepinephrine infusion
4 mg/4 mL (1 mg/mL)
n/a
0.8 mg (0.8 mL) norepinephrine + 49.2 mL D5W Final volume: 50 mL
0.016 mg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours
KCL-Y D5W-Y NS-Y
Octreotide infusion 500 mcg/1 mL (500 mcg/mL)
n/a
500 mcg (1 mL) octreotide + 49 mL NS Final volume: 50 mL
10 mcg/mL Continuous infusion Units=mcg/kg/hour Stability: 24 hours
KCL-Y D5W-Y NS-Y
ondansetron (Zofran®)
4 mg/2 mL (2 mg/mL)
n/a
2 step DILUTION 1- Withdraw exact dose
2- Dilute with equal parts for final concentration of 1 mg/mL with NS
1 mg/mL 15 minutes KCL-Y D5W-Y NS-Y
Not in nicu pyxis
pantoprazole (Pantoloc®)
40 mg NS
2 step DILUTION 1- Dilute vial with 10 mL NS to
make 4 mg/mL
2- Withdraw exact dose and further dilute with NS to final concentration of 0.4 mg/mL
0.4 mg/mL 15 minutes
KCL-Y D5W-Y NS-Y
Not in nicu pyxis
penicillin G 1 million NS SW D5W
2 step DILUTION 1- Dilute vial with 1.8 mL NS
to make 500,000 units/mL
2- Withdraw exact dose and further dilute with NS to final concentration of 50,000 units/mL
50,000 units/mL
30 minutes KCL-Y D5W-Y NS-Y
See example sheet
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
12 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
PHENobarbital
30 mg/1 mL (30 mg/mL)
n/a
2 step DILUTION 1- Withdraw exact dose
2- Further dilute with NS to final concentration of 10 mg/mL
10 mg/mL 30 minutes (Max 1 mg/kg/min)
KCL-Y D5W-Y NS-Y
See example sheet
phentolamine 5 mg/1 mL (5 mg/mL)
n/a
Withdraw 1 mL (5 mg) + 9 mL NS Final volume 10 mL
0.5 mg/mL Administer per extravasation policy
phenytoin doses less than 5 mg (Dilantin®)
100 mg/2 mL (50 mg/mL)
n/a
3 step DILUTION 1. Withdraw exact dose
2. Further dilute with NS to 5 mg/mL
3. Add remaining volume to equal 1 mL final volume
n/a 30 minutes
KCL-N D5W-N NS-Y
Administer with 0.22 micron filter NS compatible ONLY Stable 2 hours after preparation
phenytoin doses 5 mg or greater (Dilantin®)
100 mg/2 mL (50 mg/mL)
n/a
2 step DILUTION 1. Withdraw exact dose
2. Further dilute with NS to 5 mg/mL
5 mg/mL 30 minutes
KCL-N D5W-N NS-Y
Administer with 0.22 micron filter NS compatible ONLY Stable 2 hours after preparation
phytonadione IV (Vitamin K®)
1 mg/0.5 mL (2 mg/mL)
n/a
For IV doses only: Withdraw exact dose needed ADD remainder volume with NS to make 2 mL final volume
n/a 10 minutes KCL-Y D5W-Y NS-Y
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
13 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
piperacillin/tazobactam
doses less than 172mg (Tazocin®)
4.5 gm NS SW
3 step DILUTION
1- Add 20 mL NS for final concentration of 172 mg/mL (piperacillin component)
2- Withdraw exact dose needed
3- Add remaining volume to equal 1 mL final volume
n/a 30 minutes
KCL-Y D5W-Y NS-Y
Note: Dosing based on piperacillin content
piperacillin/tazobactam
doses 172 mg or greater (Tazocin®)
4.5 gm NS SW
2 step DILUTION
1- Add 20 mL NS for final concentration of 172 mg/mL (piperacillin component)
2- Withdraw exact dose needed
172 mg/mL piperacillin component
30 minutes
KCL-Y D5W-Y NS-Y
Note: Dosing based on piperacillin content
procainamide infusion 1000 mg/10 mL
(100 mg/mL) n/a
100 mg (1 mL) procainamide + 49 mL NS Final volume: 50 mL
2 mg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours
KCL-Y D5W-N NS-Y
Not stable in dextrose
raNITIdine doses less than 1 mg (Zantac®)
50 mg/2 mL (25 mg/mL)
n/a
3 step DILUTION 1- Withdraw exact dose
2- Further dilute with NS to 1 mg/mL
3- Add remaining volume to equal 1 mL
n/a 15 minutes KCL-Y D5W-Y NS-Y
See example sheet
raNITIdine doses 1 mg or greater (Zantac®)
50 mg/2 mL (25 mg/mL)
n/a
2 step DILUTION 1. Withdraw exact dose
2. Further dilute with NS to 1 mg/mL
1 mg/mL 15 minutes KCL-Y D5W-Y NS-Y
See example sheet
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
14 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
rocuronium doses less than 1 mg (Zemuron®)
50 mg/5 mL (10 mg/mL)
n/a
1 mL (10 mg) rocuronium + 9 mL D5W Final volume 10 mL Final concentration 1 mg/mL
1 mg/mL
Withdraw dose (using 1 mg/mL concentration) and ADD extra D5W to make 1 mL Give manual IVP over 1 minute
KCL-Y D5W-Y NS-Y
Warning, paralytic, should always be given in combination with analgesia /sedation
rocuronium doses 1 mg or greater
(Zemuron®)
50 mg/5 mL (10 mg/mL)
n/a Withdraw exact dose Add extra volume with D5W to make 1 mL if needed
n/a Give manual IVP over 1 minute
KCL-Y D5W-Y NS-Y
Warning, paralytic, should always be given in combination with analgesia /sedation
Sodium Bicarbonate 4.2% infusion
0.5 mEq/mL n/a Withdraw exact dose from prefilled syringe into empty syringe
0.5 mEq/mL Continuous infusion Units: 0.5-1 mEg/kg/hour
Stability: 24 hours
KCL-Y D5W-Y NS-Y
succinylcholine doses less than 2 mg
400 mg/20 mL (20 mg/mL)
n/a
0.5 mL (10 mg) of succinylcholine + 9.5 mL D5W Final volume 10 mL Final concentration 1 mg/mL
1 mg/mL Use this to withdraw your bolus dose
Withdraw dose (using 1 mg/mL concentration) and ADD extra D5W to make 1 mL Give manual IVP over 1 minute
KCL-Y D5W-Y NS-Y
Warning, paralytic, should always be given in combination with analgesia /sedation
succinylcholine doses 2 mg or greater
400 mg/20 mL (20 mg/mL
n/a Withdraw exact dose Add extra volume with D5W to make 1 mL if needed
n/a Give manual IVP over 1 minute
KCL-Y D5W-Y NS-Y
Warning, paralytic, should always be given in combination with analgesia /sedation
tobramycin doses less than 5 mg
20 mg/2 mL (10 mg/mL)
n/a
3 step DILUTION 1. Withdraw exact dose
2. Further dilute with NS to 5 mg/mL
3. Add remaining volume to make 1 mL
n/a 60 minutes KCL-Y D5W-Y NS-Y
See example sheet-NOTE concentration of vial**
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020
15 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition
Drug Vial (Concentration)
Reconstitution Solution
Instructions for Dilution Final Concentration
Administration Compatibility Other
tobramycin doses 5 mg or greater
20 mg/2 mL (10 mg/mL)
n/a
2 step DILUTION 1- Withdraw exact dose
2- Further dilute with NS to 5 mg/mL
5 mg/mL 60 minutes KCL-Y D5W-Y NS-Y
See example sheet
vancomycin (Vancocin®)
500 mg SW
2 step DILUTION 1- Add 10 mL SW to make
50 mg/mL
2- Withdraw exact dose and further dilute to 5 mg/mL with NS
5 mg/mL 60 minutes (longer in redmans reaction)
KCL-Y D5W-Y NS-Y
See example sheet
vasopressin infusion 20 units/1 mL (20 units/mL)
NS
20 units (1 mL) vasopressin + 39 mL NS Final volume: 40 mL
0.5 units/mL (500 milliunits/mL)
Continuous infusion Units=milliunits/kg/min Stability: 24 hours
KCL-Y D5W-Y NS-Y