15
Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition Drug Vial (Concentration) Reconstitution Solution Instructions for Dilution Final Concentration Administration Compatibility Other acyclovir doses less than 250 mg 500 mg/10 mL (50 mg/mL) n/a 2 step DILUTION 1- Withdraw exact dose 2- Further dilute with NS to final concentration of 5 mg/mL 5 mg/mL 60 minutes KCL- Y D5W-Y NS-Y Adenosine doses less than 0.6 mg 6 mg/2 mL (3 mg/mL) NS Withdraw 1 mL (3 mg) of adenosine + 9 mL Normal Saline Final volume=10 mL 0.3 mg/mL IV push over 1 second followed by immediate NS flush in IV line closest to heart KCL- Y D5W-Y NS-Y For SVT Dose=0.05 mg/kg, increase dose in 0.05 mg/kg increments every 2 minutes until return of sinus rhythm. Max dose 0.25 mg/kg Adenosine doses 0.6 mg or greater 6 mg/2 mL (3 mg/mL) n/a Withdraw exact dose 3 mg/mL IV push over 1 second followed by immediate NS flush in IV line closest to heart KCL- N D5W-Y NS-Y For SVT Dose=0.05 mg/kg, increase dose in 0.05 mg/kg increments every 2 minutes until return of sinus rhythm. Max dose 0.25 mg/kg alprostadil infusion 500 mcg/1 mL (500 mcg/mL) N/A 500 mcg (1 mL) alprostadil + 49 mL D5W Final volume: 50 mL 10 mcg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours KCL- Y D5W-N NS-Y amiodarone infusion 150 mg/3 mL (50 mg/mL) N/A 100 mg (2mL) amiodarone + 48 mL D5W Final volume: 50 mL 2 mg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours KCL- Y D5W-Y NS-Y Amphotericin B- liposomal (Ambisome®) doses less than 50 mg 50 mg SW 2 step DILUTION 1- Add 12 mL SW to make 4 mg/mL 2- Withdraw exact dose and further dilute with D5W to final concentration 1 mg/mL 1 mg/mL 120 minutes KCL-N NS-N D5W-Y Prepared by Pharmacy Must be filtered with greater than 1 micron filter Compatible with D5W only

Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

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Page 1: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

1 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

acyclovir doses less than 250 mg

500 mg/10 mL (50 mg/mL)

n/a

2 step DILUTION 1- Withdraw exact dose

2- Further dilute with NS to final concentration of 5 mg/mL

5 mg/mL 60 minutes KCL- Y D5W-Y NS-Y

Adenosine doses less than 0.6 mg

6 mg/2 mL (3 mg/mL)

NS

Withdraw 1 mL (3 mg) of adenosine + 9 mL Normal Saline Final volume=10 mL

0.3 mg/mL

IV push over 1 second followed by immediate NS flush in IV line closest to heart

KCL- Y D5W-Y NS-Y

For SVT Dose=0.05 mg/kg, increase dose in 0.05 mg/kg increments every 2 minutes until return of sinus rhythm. Max dose 0.25 mg/kg

Adenosine doses 0.6 mg or greater

6 mg/2 mL (3 mg/mL)

n/a Withdraw exact dose 3 mg/mL

IV push over 1 second followed by immediate NS flush in IV line closest to heart

KCL- N D5W-Y NS-Y

For SVT Dose=0.05 mg/kg, increase dose in 0.05 mg/kg increments every 2 minutes until return of sinus rhythm. Max dose 0.25 mg/kg

alprostadil infusion 500 mcg/1 mL (500 mcg/mL)

N/A

500 mcg (1 mL) alprostadil + 49 mL D5W Final volume: 50 mL

10 mcg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours

KCL- Y D5W-N NS-Y

amiodarone infusion 150 mg/3 mL (50 mg/mL)

N/A

100 mg (2mL) amiodarone + 48 mL D5W Final volume: 50 mL

2 mg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours

KCL- Y D5W-Y NS-Y

Amphotericin B-liposomal (Ambisome®)

doses less than 50 mg

50 mg SW

2 step DILUTION 1- Add 12 mL SW to make

4 mg/mL

2- Withdraw exact dose and further dilute with D5W to final concentration 1 mg/mL

1 mg/mL 120 minutes KCL-N NS-N D5W-Y

Prepared by Pharmacy Must be filtered with greater than 1 micron filter

Compatible with D5W only

Page 2: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

2 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

ampicillin doses less than 100 mg

250 mg

SW (preferred) NS D5W (Stability

grossly ↓, not recommended)

Add 2.5 mL SW and withdraw exact dose Add remaining volume to equal 1 mL final volume

n/a 15 minutes KCL- Y D5W-N NS-Y

Use within 1 hour of reconstitution

ampicillin doses 100-250 mg

250 mg

SW (preferred) NS D5W (Stability grossly ↓, not recommended)

Add 2.5 mL SW and withdraw exact dose 100 mg/mL 15 minutes KCL- Y D5W-N NS-Y

Use within 1 hour of reconstitution

ampicillin doses 251 mg or greater

500 mg

SW (preferred) NS D5W (Stability

grossly ↓, not recommended)

Add 5 mL SW and withdraw exact dose 100 mg/mL 15 minutes KCL- Y D5W-N NS-Y

Use within 1 hour of reconstitution

Atropine doses less than 0.01 mg

0.5 mg/5 mL prefilled syringe

(0.1 mg/mL)

n/a

Withdraw 1 mL (0.1 mg) of atropine ADD 9 mL NS Final volume=10 mL Final concentration=0.01 mg/mL

0.01 mg/mL Use this to withdraw your bolus dose

Withdraw dose (using 0.01 mg/mL concentration) and ADD extra NS to make 1 mL Give by manual IVP over 1 minute

KCL-Y D5W-Y NS-Y

Atropine doses 0.01 mg or greater

0.5 mg/5 mL prefilled syringe

(0.1 mg/mL)

n/a

Withdraw exact dose needed, add extra volume of NS if needed to make 1 mL

n/a Give by manual IVP over 1 minute

KCL-Y D5W-Y NS-Y

azithromycin (Zithromax®)

500 mg SW

2 step DILUTION 1- Add 5 mL SW to make

100 mg/mL

2- Withdraw exact dose and further dilute with NS to a final concentration of 2 mg/mL

2 mg/mL 60 minutes KCL-N D5W-Y NS-Y

blood products (includes platelets, FFP, Cryoprecipitate)

n/a n/a n/a n/a Infuse per MD order

n/a

Use Blood filter Expires in 4 hours!

Page 3: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

3 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

caffeine citrate doses less than 20 mg

60 mg/3 mL (20 mg/mL)

n/a Withdraw exact dose Add Remainder of volume to make final volume 1 mL with D5W

n/a 10 minutes KCL-Y D5W-Y NS-Y

caffeine citrate doses 20 mg or greater

60 mg/3 mL (20 mg/mL)

n/a Withdraw exact dose and infuse 20 mg/mL 10 minutes KCL-Y D5W-Y NS-Y

calcium gluconate 1000 mg/10 mL

(100 mg/mL) n/a

Withdraw exact dose Dilute with NS equal parts for final concentration 50 mg/mL

50 mg/mL 60 minutes KCL-Y D5W-Y NS-Y

caspofungin

doses less than 25 mg 50 mg NS

2 step DILUTION 1- Add 10.8 mL of NS to make

5 mg/mL

2- Withdraw exact dose and further dilute with NS to final concentration of 0.5 mg/mL

0.5 mg/mL 60 minutes KCL-Y D5W-N NS-Y

Prepared by pharmacy Note: dosing in BSA*

ceFAZolin doses less than 100 mg

(Ancef®) 1000 mg

NS D5W SW

Add 10 mL NS and withdraw exact dose Add remaining volume to equal 1 mL final volume

n/a 30 minutes KCL-Y D5W-Y NS-Y

ceFAZolin doses 100 mg or greater (Ancef®)

1000 mg NS D5W SW

Add 10 mL NS and withdraw exact dose

100 mg/mL 30 minutes KCL-Y D5W-Y NS-Y

cefotaxime doses less than 100 mg

(Claforan®) 1000 mg

NS D5W SW

Add 10 mL NS and withdraw exact dose Add remaining volume to equal 1 mL final volume

n/a 30 minutes KCL-Y D5W-Y NS-Y

cefotaxime doses 100 mg or greater (Claforan®)

1000 mg NS D5W SW

Add 10 mL NS and withdraw exact dose 100 mg/mL 30 minutes KCL-Y D5W-Y NS-Y

cefTAZidime doses less than 100 mg

(Fortaz®) 1000 mg

NS D5W SW

Add 10 mL NS and withdraw exact dose Add remaining volume to equal 1 mL final volume

n/a 30 minutes KCL-Y D5W-Y NS-Y

Page 4: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

4 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

cefTAZidime doses 100 mg or greater (Fortaz®)

1000 mg NS D5W SW

Add 10 mL NS and withdraw exact dose 100 mg/mL 30 minutes KCL-Y D5W-Y NS-Y

cefTRIAXone (Rocephin®)

1000 mg NS D5W SW

Add 10 mL NS and withdraw exact dose 100 mg/mL 30 minutes

KCL-Y D5W-Y NS-Y

Not to be used in premature infants or patients with hyperbilirubinemianot in NICU pyxis,

clindamycin (Dalacin C®)

300 mg/2 mL (150 mg/mL)

n/a

2 step DILUTION 1- Withdraw exact dose

2- Further dilute with NS to final concentration of 10 mg/mL

10 mg/mL 30 minutes

KCL-Y D5W-Y NS-Y

cloxacillin doses less than 20 mg

500 mg SW

3 step DILUTION 1- Add 5 mL SW to make

100 mg/mL concentration

2- Withdraw exact dose and further dilute with NS to final concentration of 20 mg/mL

3- Add remainder of volume to make 1 mL

n/a 30 minutes

KCL-N D5W-Y NS-Y

cloxacillin doses 20 mg or greater

500 mg SW

2 step DILUTION 1- Add 5 mL SW to make

100 mg/mL concentration

2- Withdraw exact dose and further dilute with NS to final concentration of 20 mg/mL

20 mg/mL 30 minutes

KCL-N D5W-Y NS-Y

Page 5: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

5 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

dexamethasone doses less than 1 mg

20 mg/5 mL (4 mg/mL)

n/a

3 step DILUTION 1- Withdraw exact dose

2- Further dilute with NS to a final concentration of 1 mg/mL

3- add remainder of volume to make 1 mL

n/a 15 minutes KCL-Y D5W-Y NS-Y

See example for dilution

dexamethasone doses 1 mg or greater

20 mg/5 mL (4 mg/mL)

n/a

2 step DILUTION 1- Withdraw exact dose

2- Further dilute with NS to a final concentration of 1 mg/mL

1 mg/mL 15 minutes KCL-Y D5W-Y NS-Y

See example for dilution

DOBUTamine 250 mg/20 mL (12.5 mg/mL)

n/a

80 mg (6.4 mL) of DOBUTamine + 43.6 mL D5W Final volume: 50 mL

1.6 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours

KCL-Y D5W-Y NS-Y

DOPamine infusion

400 mg/250 mL premixed bag (1.6 mg/mL)

n/a Withdraw 50 mL DOPamine into a 60 mL syringe (straight drug)

1.6 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours

KCL-Y D5W-Y NS-Y

EPINEPHrine infusion

1 mg/10 ml prefilled syringe (0.1 mg/mL)

n/a

0.5 mg (5 mL) EPINEPHrine + 45 ml D5W Final volume: 50 ml

0.01 mg/ml Continuous infusion Units=mcg/kg/min Stability: 24 hours

KCL-Y D5W-Y NS-Y

ertapenem doses less than 20 mg (Invanz®)

1000 mg NS

3 step DILUTION 1- Add 10 mL NS to make

100 mg/mL

2- Withdraw exact dose and further dilute with NS to final concentration of 20 mg/mL

3- Add remaining volume to equal 1 mL final volume

n/a 30 minutes KCL-Y D5W-N NS-Y

Prepared by pharmacy Incompatible with D5W

Page 6: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

6 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

ertapenem doses 20 mg or greater (Invanz®)

1000 mg NS

2 step DILUTION 1. Add 10 mL NS to make

100 mg/mL

2. Withdraw exact dose and further dilute with NS to final concentration of 20 mg/mL

20 mg/mL 30 minutes KCL-Y D5W-N NS-Y

Prepared by pharmacy Incompatible with D5W

esmolol infusion 2500 mg/250 mL premixed bag (10 mg/mL)

n/a Withdraw 50 mL esmolol into a 60 mL syringe (straight drug)

10 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours

KCL-Y D5W-Y NS-Y

fentaNYL bolus doses less than 5 mCg

100 mcg/2 mL (50 mcg/mL)

D5W NS SW

Withdraw 1 mL (50 mCg) of fentaNYL ADD 9 mL D5W Final volume=10 mL Final concentration=5 mCg/mL

5 mcg/mL Use this to withdraw your bolus dose

Withdraw dose (using 5 mcg/mL concentration) and ADD extra D5W to make 1 mL and run on pump over 10 minutes (minimum over 3-5 minutes)

KCL-Y D5W-Y NS-Y

fentaNYL bolus doses 5 mCg or greater

100 mcg/2 mL (50 mcg/mL)

n/a Withdraw exact dose needed

n/a

If bolus dose is less than 1 mL (using straight drug from vial) ADD extra D5W/NS/SW to make 1 mL and run on pump over 10 minutes (minimum 3-5 minutes)

KCL-Y D5W-Y NS-Y

fentaNYL infusion 100 mcg/2 mL (50 mcg/mL)

n/a

100 mcg (2mL) fentanyl + 8 mL D5W Final volume: 10 mL

10 mcg/mL Continuous infusion Unit=mcg/kg/hour Stability: 30 hours

KCL-Y D5W-Y NS-Y

fluconazole (Diflucan®)

200 mg/100 mL premixed vial

(2 mg/mL) n/a Withdraw and infuse exact dose 2 mg/mL 120 minutes

KCL-Y NS-Y D5W-Y

Straight drug from vial

furosemide (Lasix®) bolus

40 mg/4 mL (10 mg/mL)

n/a Exact dose – No dilution 10 mg/mL IVP over 2-5 minutes

KCL-Y D5W-Y NS-Y

Page 7: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

7 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

furosemide infusion 40 mg/4 mL (10 mg/mL)

n/a

40 mg (4 mL) furosemide + 36 mL D5W Final volume=40 mL

1 mg/mL Continuous infusion Units=mg/kg/hour Stability: 30 hours

KCL-Y D5W-Y NS-Y

ganciclovir 500 mg SW Prepared by pharmacy (Hazardous)

5 mg/mL

Infuse over 60 minutes Flush pre/post with NS

KCL-Y D5W-Y NS-Y

**Cytotoxic** must be prepared in chemo hood, contact 4WES for chemo bin for disposal of drug

gentamicin (Garamicin®) doses less than 5 mg

20 mg/2 mL (10 mg/mL)

n/a

3 step DILUTION 1- Withdraw exact dose

2- Further dilute with NS to 5 mg/mL

3- Add remaining volume to make 1 mL

n/a 60 minutes KCL-Y D5W-Y NS-Y

See example sheet-NOTE concentration of vial**

gentamicin (Garamicin®) doses 5 mg or greater

20 mg/2 mL (10 mg/mL)

n/a

2 step DILUTION 1 Withdraw exact dose

2. Further dilute with NS to 5 mg/mL

5 mg/mL 60 minutes KCL-Y D5W-Y NS-Y

See example sheet-NOTE concentration of vial**

glucagon infusion Glucagon kit (1 mg/mL)

w/glucagon diluent

Reconstitute glucagon kit 1 mg (1 mL) glucagon + 24 mL D10W Final volume: 25 mL

40 mcg/mL

Continuous infusion Units=mcg/kg/hour Stability: 24 hours

KCL-N D5W-Y NS-N

hydrocortisone 100 mg/2 mL Act-O-Vial (50 mg/mL)

n/a

Dilute per instructions on vial Withdraw 50 mg (1 mL) Insert in 50 mL NS bag Giving a final concentration 1 mg/mL Withdraw exact dose needed If dose is less than 1 mL add remaining volume to equal 1 mL final volume

1 mg/mL 15 minutes KCL-Y D5W-Y NS-Y

Page 8: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

8 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

indomethacin IV 1 mg vial NS/SW only

Reconstitute 1 mg vial with 1 mL of NS/SW (to make 1 mg/mL) Withdraw dose needed and add enough NS/D5W to make final volume 2 mL

n/a 30 minutes

KCL-Y D5W-Y NS-Y

Special access NOT compatible with D10W

insulin infusion

300 units/3 mL

(100 units/mL) Insulin GE TORONTO

n/a

Withdraw 50 units (0.5 mL) insulin Inject in a 500 ml bag 0.9% NaCL Invert bag few times Withdraw 50 mL of solution into a 60 mL syringe and prime syringe tubing. Let insulin saturate tubing for at least 20 minutes prior to administration Discard remainder of bag

0.1 units/mL Continuous infusion Units=units/kg/hour

Stability: 24 hours

KCL-Y D5W-Y NS-Y

levETIRAcetam (Keppra®)

500 mg/5 mL (100 mg/mL)

n/a

2 step DILUTION 1- Withdraw exact dose

2- Further dilute with NS to 10 mg/mL

10 mg/mL 15 minutes KCL-N D5W-Y NS-Y

See example for dilution Special Access

lidocaine infusion

2000 mg/500 mL premixed bag (4 mg/mL )

n/a Withdraw 50 mL lidocaine into a 60 mL syringe (straight drug)

4 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours

KCL-Y D5W-Y NS-Y

linezolid (Zyvoxam®)

600 mg/300 mL premixed bag (2 mg/mL)

n/a Pharmacy to prepare 2 mg/mL 60 minutes KCL-Y D5W-Y NS-Y

lipids (SMOF®)

50,000 mg/250 mL premixed bag (200 mg/mL)

n/a Infuse as ordered over 24 hours n/a mL/hr KCL-Y D5W-Y NS-Y

See example sheet for rate calculation

LORazepam (Ativan®) Doses less than 0.4 mg

4 mg/mL (4 mg/mL)

n/a

Withdraw 1 mL (4 mg) of lorazepam ADD 7 mL NS Final volume=8 mL Final concentration=0.5 mg/mL

0.5 mg/mL Use this to withdraw your bolus dose

Withdraw dose (using 0.5 mg/mL concentration) and ADD extra NS to make 1 mL Give IVP over 5-10 minutes

KCL-Y D5W-Y NS-Y

Page 9: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

9 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

LORazepam (Ativan®) Doses 0.4 mg or greater

4 mg/mL (4 mg/mL)

n/a Withdraw exact dose, if volume less than 1 mL add remaining volume to equal 1 mL final volume

4 mg/mL IVP over 5-10 minutes

KCL-Y D5W-Y NS-Y

magnesium sulfate 2000 mg/10 mL

(200 mg/mL) n/a

2 Step DILUTION 1- Withdraw exact dose

2- Further dilute with NS for a final concentration of 50 mg/mL

50 mg/mL

Electrolyte replacement: 60 minutes

KCL-Y D5W-Y NS-Y

Not in NICU pyxis

meropenem doses less than 20 mg (Merrem®)

500 mg SW

3 step DILUTION 1- Reconstitute with 10 mL

SW to make 50 mg/mL

2- Withdraw exact dose and further dilute to final concentration of 20 mg/mL with NS

3- Add remaining volume to equal 1 mL final volume

n/a 30 minutes KCL-Y D5W-Y NS-Y

meropenem doses 20 mg or greater (Merrem®)

500 mg SW

2 step DILUTION 1. Reconstitute with 10

mL SW to make 50 mg/mL

2. Withdraw exact dose and further dilute to final concentration of 20 mg/mL with NS

20 mg/mL 30 minutes KCL-Y D5W-Y NS-Y

metoclopramide (Maxeran®)

10 mg/2mL (5 mg/mL)

n/a

2 step DILUTION 1- Withdraw exact dose

2- Further dilute to 0.2 mg/mL with NS

0.2 mg/mL 30 minutes KCL-Y D5W-Y NS-Y

See example sheet

metroNIDAZOLE (Flagyl®)

500 mg/100 mL premixed bag (5 mg/mL)

n/a Already diluted Withdraw/Infuse exact dose

5 mg/mL 60 minutes KCL-Y D5W-Y NS-Y

Straight drug from premix bag protect from light

Page 10: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

10 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

midazolam bolus doses less than 0.5 mg (Versed®)

5 mg/1 mL (5 mg/mL)

n/a

Withdraw 1 mL (5 mg) of midazolam ADD 9 mL D5W Final volume=10 mL, final concentration=0.5 mg/mL

0.5 mg/mL Use this to withdraw your bolus dose

Withdraw dose (using 0.5 mg/mL concentration) and ADD extra D5W to make 1 mL and run on pump over 10 minutes (minimum 3-5 minutes)

KCL-Y D5W-Y NS-Y

midazolam bolus doses 0.5 mg or greater (Versed®)

5 mg/1 mL (5 mg/mL)

n/a

*Note concentration of vial* NO dilution -Withdraw exact dose and add remaining D5W to make final volume 1 mL

n/a

IVP ONLY over 10 minutes (neofax)- minimum time 3-5 minutes

KCL-Y D5W-Y NS-Y

midazolam infusion (Versed®)

5 mg/1 mL (5 mg/mL)

n/a

10 mg (2mL) midazolam + 8 mL D5W Final volume=10 mL

1 mg/ml Continuous infusion Units=mg/kg/HOUR Stability: 30 hours

KCL-Y D5W-Y NS-Y

milrinone infusion 10 mg/10 mL (1 mg/mL)

n/a

10 mg (10 mL) milrinone + 40 mL D5W Final volume: 50 mL

0.2 mg/mL Continuous infusion Units=mcg/kg/min Stability: 30 hours

KCL-Y D5W-Y NS-Y

Morphine bolus doses less than 0.2 mg

2 mg/1 mL (2 mg/mL)

n/a

Withdraw 1 mL (2 mg) of morphine ADD 9 mL D5W Final volume=10 mL final concentration=0.2 mg/mL

0.1 mg/mL Use this to withdraw your bolus dose

Withdraw dose (using 0.2 mg/mL concentration)and ADD extra D5W to make 1 mL and run on pump over 10 minutes (minimum time 3-5 minutes)

KCL-Y D5W-Y NS-Y

morphine bolus doses 0.2 mg or greater

2 mg/1 mL (2 mg/mL)

n/a

NO dilution -Withdraw exact dose and add remaining diluent volume to make final volume 1 mL

n/a

IVPB 10 minutes (minimum time 3-5 minutes)

KCL-Y D5W-Y NS-Y

morphine infusion 2 mg/1 mL (2 mg/mL)

n/a

2 mg (1 mL) morphine + 49 mL D5W Final volume: 50 mL

40 mcg/mL Continuous infusion Units=mcg/kg/hour

Stability: 30 hours

KCL-Y D5W-Y NS-Y

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Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

11 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

naloxone (Narcan®)

2 mg/2 mL (1 mg/mL)

n/a No Dilution **Note concentration of vial**

1 mg/mL IVP over 30 seconds KCL-Y D5W-Y NS-Y

naloxone Infusion (Narcan®)

2 mg/2 mL (1 mg/mL)

n/a

0.2 mg (0.2 mL) naloxone + 49.8 mL NS Final Volume: 50 mL

4 mcg/mL Continuous infusion Units=mcg/kg/hour Stability: 24 hours

KCL-Y D5W-Y NS-Y

norepinephrine infusion

4 mg/4 mL (1 mg/mL)

n/a

0.8 mg (0.8 mL) norepinephrine + 49.2 mL D5W Final volume: 50 mL

0.016 mg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours

KCL-Y D5W-Y NS-Y

Octreotide infusion 500 mcg/1 mL (500 mcg/mL)

n/a

500 mcg (1 mL) octreotide + 49 mL NS Final volume: 50 mL

10 mcg/mL Continuous infusion Units=mcg/kg/hour Stability: 24 hours

KCL-Y D5W-Y NS-Y

ondansetron (Zofran®)

4 mg/2 mL (2 mg/mL)

n/a

2 step DILUTION 1- Withdraw exact dose

2- Dilute with equal parts for final concentration of 1 mg/mL with NS

1 mg/mL 15 minutes KCL-Y D5W-Y NS-Y

Not in nicu pyxis

pantoprazole (Pantoloc®)

40 mg NS

2 step DILUTION 1- Dilute vial with 10 mL NS to

make 4 mg/mL

2- Withdraw exact dose and further dilute with NS to final concentration of 0.4 mg/mL

0.4 mg/mL 15 minutes

KCL-Y D5W-Y NS-Y

Not in nicu pyxis

penicillin G 1 million NS SW D5W

2 step DILUTION 1- Dilute vial with 1.8 mL NS

to make 500,000 units/mL

2- Withdraw exact dose and further dilute with NS to final concentration of 50,000 units/mL

50,000 units/mL

30 minutes KCL-Y D5W-Y NS-Y

See example sheet

Page 12: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

12 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

PHENobarbital

30 mg/1 mL (30 mg/mL)

n/a

2 step DILUTION 1- Withdraw exact dose

2- Further dilute with NS to final concentration of 10 mg/mL

10 mg/mL 30 minutes (Max 1 mg/kg/min)

KCL-Y D5W-Y NS-Y

See example sheet

phentolamine 5 mg/1 mL (5 mg/mL)

n/a

Withdraw 1 mL (5 mg) + 9 mL NS Final volume 10 mL

0.5 mg/mL Administer per extravasation policy

phenytoin doses less than 5 mg (Dilantin®)

100 mg/2 mL (50 mg/mL)

n/a

3 step DILUTION 1. Withdraw exact dose

2. Further dilute with NS to 5 mg/mL

3. Add remaining volume to equal 1 mL final volume

n/a 30 minutes

KCL-N D5W-N NS-Y

Administer with 0.22 micron filter NS compatible ONLY Stable 2 hours after preparation

phenytoin doses 5 mg or greater (Dilantin®)

100 mg/2 mL (50 mg/mL)

n/a

2 step DILUTION 1. Withdraw exact dose

2. Further dilute with NS to 5 mg/mL

5 mg/mL 30 minutes

KCL-N D5W-N NS-Y

Administer with 0.22 micron filter NS compatible ONLY Stable 2 hours after preparation

phytonadione IV (Vitamin K®)

1 mg/0.5 mL (2 mg/mL)

n/a

For IV doses only: Withdraw exact dose needed ADD remainder volume with NS to make 2 mL final volume

n/a 10 minutes KCL-Y D5W-Y NS-Y

Page 13: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

13 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

piperacillin/tazobactam

doses less than 172mg (Tazocin®)

4.5 gm NS SW

3 step DILUTION

1- Add 20 mL NS for final concentration of 172 mg/mL (piperacillin component)

2- Withdraw exact dose needed

3- Add remaining volume to equal 1 mL final volume

n/a 30 minutes

KCL-Y D5W-Y NS-Y

Note: Dosing based on piperacillin content

piperacillin/tazobactam

doses 172 mg or greater (Tazocin®)

4.5 gm NS SW

2 step DILUTION

1- Add 20 mL NS for final concentration of 172 mg/mL (piperacillin component)

2- Withdraw exact dose needed

172 mg/mL piperacillin component

30 minutes

KCL-Y D5W-Y NS-Y

Note: Dosing based on piperacillin content

procainamide infusion 1000 mg/10 mL

(100 mg/mL) n/a

100 mg (1 mL) procainamide + 49 mL NS Final volume: 50 mL

2 mg/mL Continuous infusion Units=mcg/kg/min Stability: 24 hours

KCL-Y D5W-N NS-Y

Not stable in dextrose

raNITIdine doses less than 1 mg (Zantac®)

50 mg/2 mL (25 mg/mL)

n/a

3 step DILUTION 1- Withdraw exact dose

2- Further dilute with NS to 1 mg/mL

3- Add remaining volume to equal 1 mL

n/a 15 minutes KCL-Y D5W-Y NS-Y

See example sheet

raNITIdine doses 1 mg or greater (Zantac®)

50 mg/2 mL (25 mg/mL)

n/a

2 step DILUTION 1. Withdraw exact dose

2. Further dilute with NS to 1 mg/mL

1 mg/mL 15 minutes KCL-Y D5W-Y NS-Y

See example sheet

Page 14: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

14 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

rocuronium doses less than 1 mg (Zemuron®)

50 mg/5 mL (10 mg/mL)

n/a

1 mL (10 mg) rocuronium + 9 mL D5W Final volume 10 mL Final concentration 1 mg/mL

1 mg/mL

Withdraw dose (using 1 mg/mL concentration) and ADD extra D5W to make 1 mL Give manual IVP over 1 minute

KCL-Y D5W-Y NS-Y

Warning, paralytic, should always be given in combination with analgesia /sedation

rocuronium doses 1 mg or greater

(Zemuron®)

50 mg/5 mL (10 mg/mL)

n/a Withdraw exact dose Add extra volume with D5W to make 1 mL if needed

n/a Give manual IVP over 1 minute

KCL-Y D5W-Y NS-Y

Warning, paralytic, should always be given in combination with analgesia /sedation

Sodium Bicarbonate 4.2% infusion

0.5 mEq/mL n/a Withdraw exact dose from prefilled syringe into empty syringe

0.5 mEq/mL Continuous infusion Units: 0.5-1 mEg/kg/hour

Stability: 24 hours

KCL-Y D5W-Y NS-Y

succinylcholine doses less than 2 mg

400 mg/20 mL (20 mg/mL)

n/a

0.5 mL (10 mg) of succinylcholine + 9.5 mL D5W Final volume 10 mL Final concentration 1 mg/mL

1 mg/mL Use this to withdraw your bolus dose

Withdraw dose (using 1 mg/mL concentration) and ADD extra D5W to make 1 mL Give manual IVP over 1 minute

KCL-Y D5W-Y NS-Y

Warning, paralytic, should always be given in combination with analgesia /sedation

succinylcholine doses 2 mg or greater

400 mg/20 mL (20 mg/mL

n/a Withdraw exact dose Add extra volume with D5W to make 1 mL if needed

n/a Give manual IVP over 1 minute

KCL-Y D5W-Y NS-Y

Warning, paralytic, should always be given in combination with analgesia /sedation

tobramycin doses less than 5 mg

20 mg/2 mL (10 mg/mL)

n/a

3 step DILUTION 1. Withdraw exact dose

2. Further dilute with NS to 5 mg/mL

3. Add remaining volume to make 1 mL

n/a 60 minutes KCL-Y D5W-Y NS-Y

See example sheet-NOTE concentration of vial**

Page 15: Neonatal Standard concentration/Dilution Medication chart Dr… · Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020 1 Reference:

Windsor Regional Hospital [NEONATAL STANDARD CONCENTRATION/DILUTION MEDICATION CHART]-updated 3.23.2020

15 Reference: LexiComp, Trissels, NeoFax, Teddy Bear Book Legend: SW= sterile water, D5W-Dextrose 5% in Water, NS= Normal Saline, KCL=Potassium Chloride, TPN= total parenteral nutrition

Drug Vial (Concentration)

Reconstitution Solution

Instructions for Dilution Final Concentration

Administration Compatibility Other

tobramycin doses 5 mg or greater

20 mg/2 mL (10 mg/mL)

n/a

2 step DILUTION 1- Withdraw exact dose

2- Further dilute with NS to 5 mg/mL

5 mg/mL 60 minutes KCL-Y D5W-Y NS-Y

See example sheet

vancomycin (Vancocin®)

500 mg SW

2 step DILUTION 1- Add 10 mL SW to make

50 mg/mL

2- Withdraw exact dose and further dilute to 5 mg/mL with NS

5 mg/mL 60 minutes (longer in redmans reaction)

KCL-Y D5W-Y NS-Y

See example sheet

vasopressin infusion 20 units/1 mL (20 units/mL)

NS

20 units (1 mL) vasopressin + 39 mL NS Final volume: 40 mL

0.5 units/mL (500 milliunits/mL)

Continuous infusion Units=milliunits/kg/min Stability: 24 hours

KCL-Y D5W-Y NS-Y