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NCBC EAB, January 2010
NA-MIC Highlights:A Core 1 Perspective
Ross WhitakerUniversity of Utah
National Alliance for Biomedical Image Computing
NCBC EAB, January 2010
Algorithms Productivity
• Publications
Clinical/BiomedicalScience
Applied MethodologyValidation/Evaluation
New methods
ICCV, PAMIMICCAI, MedIA, TMI
NeuroImage AJNRThings we have not yet published
Things we have hardly thought about
NCBC EAB, January 2010
Algorithms Productivity
• Software and tools
Adopted by unaffiliated groups
Proof of conceptReusable (by friends)
One-off prototypes
NCBC EAB, January 2010
Algorithms Productivity
• The real goal
ClinicalPractice
NCBC EAB, January 2010
Diffusion MRI in Schizophrenia
Lee et al, “ Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a Diffusion Tensor Imaging study”, Schiz. Res. 2009.
Tissue classification and hand segmentation of STG
Group differences and correlations with DTI measures
NCBC EAB, January 2010
DTI in Neurodevelopment
Goodlett et. al, “Group analysis of DTI fi ber tract statistics with application to neurodevelopment”, Neuroimage, 2009.
NCBC EAB, January 2010
Longitudinal Studies of DTIGouttard et. al, “Constrained Data Decomposition andRegression for Analyzing Healthy Aging fromFiber Tract Diffusion Properties”, MICCAI, 2009.Atlas based alignment and tract identification
Localized statistics on longitudinal models
NCBC EAB, January 2010
Atlases and Segmentation for Scientific Studies
Leemput et al., “Automated Segmentation of Hippocampal Subfields From Ultra-High Resolution In Vivo MRI”, Hippocampus, 2009.
Bayesian Image analysis for parcellation of the hippocampus
NCBC EAB, January 2010
New Technologies for Atlases/Segmentation
Riklin Raviv et al., “Joint Segmentation of Image Ensembles via Latent Atlases”, MICCAI 2009
Gerber et al., “On The Manifold Structure of the Space of Brain Images”, MICCAI 2009
Bootstrapping atlas with very little prior data
Discovering/utilizing underlying parameters of large image databases
NCBC EAB, January 2010
New Technologies for Segmentation
Prastawa et al., “Stastical analysis and segmentation with pathology”, 2010
Karasev et al., “Conformal Geometric Flows for Surface Segmentation”, 2010
Applications of statistical atlases with allowances for outliers
Region specification by geometric flows on surfaces
NCBC EAB, January 2010
Shape Analysis in Schizophrenia
Levitt et al., “Shape abnormalities of caudate nucleus in schizotypal personality disorder”, Schiz. Res., 2009.
Global and local caudate shape abnormalities in male and female SPD
NCBC EAB, January 2010
Correspondence and Shape: Multimodal, Cortex
Oguz et al., “Cortical correspondence with probabilistic fiberconnectivity”, IPMI, 2009.
Combine shape and connectivity for group correspondence
More consistent alignment of cortex relative to state of the art
NCBC EAB, January 2010
Shape and Regression/Development
Datar et al., “Particle Based Shape Regression of Open Surfaces with Applications to Developmental Neuroimaging”, MICCAI, 2009.
Correspondence incorporate an underlying developmental model
NCBC EAB, January 2010
Where We Are Headed
ClinicalPractice
New Ideas
Biomedical/Clinical Science
NCBC EAB, January 2010
Stay Tuned!• Investigators:
– P. Golland – MIT– A. Tannenbaum – Georgia
Tech– M. Stynder – UNC– G. Gerig – Utah
